2014-09-05: BioLiP was updated with 290,340 entries.
2014-08-29: BioLiP was updated with 289,726 entries.
2014-08-22: BioLiP was updated with 289,183 entries.
2014-08-15: BioLiP was updated with 287,808 entries.
2014-08-08: BioLiP was updated with 286,977 entries.
2014-08-01: BioLiP was updated with 285,404 entries.
2014-07-25: BioLiP was updated with 284,044 entries.
2014-07-18: BioLiP was updated with 283,521 entries.
2014-07-11: BioLiP was updated with 282,354 entries.
2014-07-04: BioLiP was updated with 281,459 entries.
2014-06-27: BioLiP was updated with 280,813 entries.
2014-06-20: BioLiP was updated with 280,296 entries.
2014-06-13: BioLiP was updated with 279,474 entries.
2014-06-06: BioLiP was updated with 278,970 entries.
2014-05-30: BioLiP was updated with 278,455 entries.
2014-05-23: BioLiP was updated with 277,782 entries.
2014-05-16: BioLiP was updated with 277,235 entries.
2014-05-09: BioLiP was updated with 276,626 entries.
2014-05-02: BioLiP was updated with 276,074 entries.
2014-04-25: BioLiP was updated with 275,646 entries.
2014-04-18: BioLiP was updated with 275,162 entries.
2014-04-11: BioLiP was updated with 274,651 entries.
2014-04-04: BioLiP was updated with 273,568 entries.
2014-03-28: BioLiP was updated with 272,557 entries.
2014-03-21: BioLiP was updated with 271,910 entries.
2014-03-14: BioLiP was updated with 271,375 entries.
2014-03-07: BioLiP was updated with 270,981 entries.
2014-02-28: BioLiP was updated with 270,316 entries.
2014-02-21: BioLiP was updated with 269,908 entries.
2014-02-14: BioLiP was updated with 269,450 entries.
2014-02-07: BioLiP was updated with 268,788 entries.
2014-01-31: BioLiP was updated with 267,713 entries.
2014-01-24: BioLiP was updated with 267,274 entries.
2014-01-17: BioLiP was updated with 266,774 entries.
2014-01-10: BioLiP was updated with 266,318 entries.
2014-01-03: BioLiP was updated with 266,002 entries.
2013-12-27: BioLiP was updated with 265,829 entries.
2013-12-20: BioLiP was updated with 265,285 entries.
2013-12-13: BioLiP was updated with 264,561 entries.
2013-12-06: BioLiP was updated with 263,760 entries.
2013-11-29: BioLiP was updated with 263,196 entries.
2013-11-22: BioLiP was updated with 262,649 entries.
2013-11-15: BioLiP was updated with 262,248 entries.
2013-11-08: BioLiP was updated with 260,849 entries.
2013-11-01: BioLiP was updated with 260,129 entries.
2013-10-25: BioLiP was updated with 259,245 entries.
2013-10-18: BioLiP was updated with 258,656 entries.
2013-10-11: BioLiP was updated with 258,317 entries.
2013-10-04: BioLiP was updated with 257,701 entries.
2013-09-27: BioLiP was updated with 257,194 entries.
2013-09-20: BioLiP was updated with 256,910 entries.
2013-09-13: BioLiP was updated with 256,315 entries.
2013-09-06: BioLiP was updated with 255,963 entries.
2013-08-30: BioLiP was updated with 255,496 entries.
2013-08-23: BioLiP was updated with 254,957 entries.
2013-08-19: A link was added at the search and browse pages to allow users to export searching results in CSV format.
2013-08-16: BioLiP was updated with 254,447 entries.
2013-08-09: BioLiP was updated with 253,952 entries.
2013-08-02: BioLiP was updated with 253,216 entries.
2013-07-26: BioLiP was updated with 252,564 entries.
2013-07-19: BioLiP was updated with 251,893 entries.
2013-07-12: BioLiP was updated with 250,703 entries.
2013-07-05: BioLiP was updated with 250,241 entries.
2013-06-28: BioLiP was updated with 249,116 entries.
2013-06-21: BioLiP was updated with 248,580 entries.
2013-06-14: BioLiP was updated with 248,096 entries.
2013-06-07: BioLiP was updated with 247,557 entries.
2013-05-31: BioLiP was updated with 246,890 entries.
2013-05-24: BioLiP was updated with 246,417 entries.
2013-05-17: BioLiP was updated with 245,911 entries.
2013-05-10: BioLiP was updated with 245,395 entries.
2013-05-03: BioLiP was updated with 244,820 entries.
2013-04-26: BioLiP was updated with 243,943 entries.
2013-04-19: BioLiP was updated with 243,042 entries.
2013-04-12: BioLiP was updated with 242,582 entries.
2013-04-05: BioLiP was updated with 241,909 entries.
2013-03-29: BioLiP was updated with 241,204 entries.
2013-03-22: BioLiP was updated with 240,565 entries.
2013-03-15: BioLiP was rebuilt with the following changes: (1) All DNA/RNA-protein interactions from PDB were added, which should be useful for studying Nucleic Acids-protein interactions. In previous versions, only small DNA/RNA ligands were considered. (2) The k-mer ligand "UUU" was divided into component ligands and removed from the database.
2013-03-08: BioLiP was updated with 217,294 entries.
2013-03-01: BioLiP was updated with 216,666 entries.
2013-02-22: BioLiP was updated with 216,087 entries.
2013-02-15: BioLiP was updated with 215,157 entries.
2013-02-08: BioLiP was updated with 214,612 entries.
2013-02-01: BioLiP was updated with 214,197 entries.
2013-01-25: BioLiP was updated with 213,766 entries.
2013-01-18: BioLiP was updated with 213,173 entries.
2013-01-11: BioLiP was updated with 212,628 entries.
2013-01-04: BioLiP was updated with 212,266 entries.
2012-12-28: BioLiP was updated with 212,036 entries.
2012-12-21: BioLiP was updated with 211,687 entries.
2012-12-14: BioLiP was updated with 211,382 entries. 102 ligands were added to the artifact ligand list, which helped us reduce about 1000 false positive entries.
2012-12-07: BioLiP was updated with 211,819 entries. 642 false postive entries for the ligands RG1 and IMD were manually removed.
2012-11-30: BioLiP was updated with 212,148 entries. The COACH algorithm was redesigned and is available at here.
2012-11-23: BioLiP was updated with 211,852 entries.
2012-11-16: BioLiP was updated with 211,040 entries. 233 false postive entries for the ligands FTT and MYR were manually removed.
2012-11-09: BioLiP was updated with 210,894 entries. The number of BioLiP entries with binding affinity data was increased from 20127 to 22091 with the latest realse of the PDBbind-CN database.
2012-11-02: BioLiP was updated with 210,377 entries. 108 false postive entries for the ligands TRD and UND were manually removed.
2012-10-26: BioLiP was updated with 209,775 entries.
2012-10-19: BioLiP was updated with 209,291 entries. BioLiP manuscript was published online in Nucleic Acids Research.
2012-10-12: BioLiP was updated with 208,649 entries. 104 false postive entries for the ligands D10, D12, DD9, HP6, and R16 were manually removed.
2012-10-05: BioLiP was updated with 208,366 entries. 69 false postive entries for the ligand LFA were manually removed.
2012-09-28: BioLiP was updated with 208,003 entries. Some minor bugs in our script were fixed, resulting the addition of about 3000 new BioLiP entries.
2012-09-21: BioLiP was updated with 204,599 entries.
2012-09-14: BioLiP was updated with 204,223 entries. (1) 21 missed true positives (for the ligand CXS) were manually added in the new release. (2) The PDB's original residue numbering system was retained.
2012-09-07: BioLiP was updated with 203,852 entries.
2012-09-01: BioLiP was updated with 203,373 entries. (1) 18 missed true positives (for the ligand PMS) were manually added in the new release. (2) A more stringent filter was added for metal ion ligands to remove 5,393 flase positives.
2012-08-25: BioLiP was updated with 208,122 entries. (1) Crystallization neighbors were excluded using the record "REMARK 350" in the PDB file. (2) Two detergent molecules (OLB, OLC) were added to the artifact list due to 232 false positives indentified.
(3) Five different keywords (BioLiP ID, PDB ID, Ligand ID, UniProt ID, and Resolution) were provided for sorting searching results.
2012-08-03: BioLiP was updated with 208,494 entries. (1) The resolution of the PDB structures was added into BioLiP. (2) The columns 18-20 in the PDB files of DNA/RNA were changed from "NUC" to the original PDB format.
(3) 41 BioLiP entries with obsolete PDB IDs were removed.
2012-07-25: BioLiP was updated with 208,184 entries.
2012-07-10: BioLiP was updated with 207,628 entries.
(1) Seven ligand molecules (XE, HG, F, TL, BA, LI, BR) were moved from the exclude list to the artifact list
(2)Ten ligand molecules (TAU, TCA, SPD, SPM, SAR, SUC, PAM, SPH, BE7, P4G) were added to the artifact list due to 387 false positives indentified.
2012-07-03: BioLiP was updated with 206,615 entries.
(1) The ligand molecule chloride (CL) was moved from the exclude list to the artifact list.
(2) 115 false positives (for 2PE, C8E, P6G, 12P, PG4, PE4, EDO, ETE, P4C, 1PE, PEG) caused by wrong keyword match "glycol" were manually removed.
2012-06-26: BioLiP was updated with 205,732 entries.
2012-06-19: The BioLiP database (with 205,373 entries) was released by Dr. Yang Zhang's research group at University of Michigan.
Reference:
Jianyi Yang, Ambrish Roy and Yang Zhang.
BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
yangzhanglabumich.edu
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umich.edu
| (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218