Department of Computational Medicine and Bioinformatics Department of Biological Chemistry University of Michigan Medical School 100 Washtenaw Avenue Ann Arbor, MI 48109-2218 Phone: (734)647-1549 Fax: (734)615-6553 Email: yangzhanglabzhanggroup.org We are interested in: Protein Structure Prediction Protein Design and Protein Engineering Structure-based Protein Function Annotation SNP Mutation and Genetic Diseases Protein-Protein Interactions Ligand Docking and Structure-Based Drug Design

Determining structure and function of protein molecules is a cornerstone of modern biology and medicine. One of the main focuses of our lab is to develop computational methods to predict 3-dimensional structure of protein molecules from amino acid sequence, and to deduce the biological functions based on the sequence-to-structure-to-function paradigm. The second focus of our lab is to combine computational algorithms and biochemistry experiments to design new protein molecules with enhanced functionality beyond nature proteins. We are also working on modeling ligand-protein and protein-protein interactions, with particular interest in new drug screening targeting G protein-coupled receptors in the human genome ( >> read more ... ).

• NSCC.SG (2023/12/26): Zhang Lab received new computing resources from National Supercomputing Centre (NSCC) for AI-based protein/RNA-folding and online gateway developments (11003846 and 11003862: 10.4 million CPU/GPU hours and 58 TBs storage).
• NUS.EDU.SG (2023/12/21): Novel AI-based approach for more accurate RNA 3D structure prediction .
• SCIENCENET.CN (2023/12/19): Dr. Weikang Gong were awarded prestigious grant supports from both China Postdoctoral Science Foundation and Union Medical College Young Scholar Support Program .

  ( >> read more Zhang Lab news ... )