ATOM 1238 CA ASP 238 1.323 -2.341 -50.054 1 PHE ATOM 1239 CA ILE 239 -2.513 -2.477 -50.269 2 SER ATOM 1240 CA HIS 240 -5.059 -2.687 -48.839 3 GLU ATOM 1241 CA ALA 241 -5.699 0.858 -47.561 4 SER ATOM 1242 CA ASP 242 -2.876 3.306 -33.769 11 THR ATOM 1243 CA ALA 243 -1.841 6.606 -35.467 12 ALA ATOM 1244 CA VAL 244 0.087 7.846 -38.593 13 ILE ATOM 1245 CA ALA 245 0.844 11.059 -40.571 14 ILE ATOM 1246 CA ILE 246 2.568 11.627 -43.992 15 THR ATOM 1247 CA THR 247 4.675 14.691 -44.721 16 LEU ATOM 1248 CA ASN 248 5.783 14.922 -48.345 17 SER ATOM 1249 CA THR 249 8.627 17.147 -49.624 18 LYS ATOM 1250 CA ASP 250 7.377 20.235 -47.740 19 ASP ATOM 1251 CA HIS 251 5.442 18.970 -44.726 20 GLY ATOM 1252 CA VAL 252 1.973 18.240 -46.104 21 ARG ATOM 1253 CA LEU 253 -0.232 15.342 -45.073 22 ILE ATOM 1254 CA ALA 254 -1.745 12.795 -47.462 23 THR ATOM 1255 CA TYR 255 -3.383 10.526 -44.872 24 GLU ATOM 1256 CA VAL 256 -4.511 11.504 -41.407 25 TRP ATOM 1257 CA GLY 257 -9.554 16.696 -32.200 34 GLY ATOM 1258 CA VAL 258 -9.764 17.337 -35.953 35 LEU ATOM 1259 CA GLY 259 -10.781 15.135 -38.893 36 LYS ATOM 1260 CA GLU 260 -8.726 14.141 -41.962 37 LYS ATOM 1261 CA HIS 261 -10.432 16.423 -44.513 38 GLU ATOM 1262 CA ASN 262 3.966 23.372 -38.032 46 LYS ATOM 1263 CA TYR 263 0.708 25.340 -38.646 47 ASP ATOM 1264 CA GLN 264 -0.904 23.777 -35.559 48 LEU ATOM 1265 CA ASN 265 -0.755 25.236 -32.003 49 PRO ATOM 1266 CA GLY 266 1.106 23.747 -28.984 50 ASP ATOM 1267 CA ASP 267 2.532 21.595 -31.771 51 PHE ATOM 1268 CA ASP 268 5.642 23.031 -33.446 52 GLU ATOM 1269 CA PHE 269 8.747 20.848 -33.092 53 GLU ATOM 1270 CA ILE 270 7.122 17.725 -34.489 54 ILE ATOM 1271 CA SER 271 7.622 19.488 -37.820 55 GLY ATOM 1272 CA PRO 272 11.100 20.792 -36.913 56 SER ATOM 1273 CA THR 273 11.994 17.177 -36.177 57 VAL ATOM 1274 CA THR 274 10.675 16.059 -39.586 58 ALA ATOM 1275 CA ARG 275 12.564 19.060 -40.980 59 GLU ATOM 1276 CA GLN 276 16.101 18.101 -39.912 60 SER ATOM 1277 CA ALA 277 15.089 14.555 -40.862 61 VAL ATOM 1278 CA MET 278 14.568 15.861 -44.383 62 PHE ATOM 1279 CA ASN 279 18.139 17.119 -44.201 63 GLU ATOM 1280 CA TYR 280 19.916 14.428 -42.175 64 ASN ATOM 1281 CA GLY 281 17.845 11.632 -43.740 65 LYS ATOM 1282 CA LYS 282 18.102 9.036 -40.898 66 GLU ATOM 1283 CA ILE 283 14.836 8.454 -38.900 67 PRO ATOM 1284 CA ILE 284 14.153 8.834 -35.146 68 VAL ATOM 1285 CA ILE 285 12.313 7.242 -32.288 69 PHE ATOM 1286 CA LYS 286 11.319 9.653 -29.532 70 LEU ATOM 1287 CA ASN 287 10.211 8.752 -26.027 71 ASN ATOM 1288 CA ASN 288 8.750 11.311 -23.642 72 PHE ATOM 1289 CA ASP 289 6.921 14.129 -25.394 73 TYR ATOM 1290 CA GLU 290 4.443 16.271 -23.496 74 LYS ATOM 1291 CA ALA 291 1.483 17.280 -25.634 75 PHE ATOM 1292 CA HIS 292 -1.024 19.045 -23.404 76 GLY ATOM 1293 CA ARG 293 -1.928 16.679 -20.560 77 GLU ATOM 1294 CA THR 294 -0.657 13.496 -22.203 78 ARG ATOM 1295 CA PRO 295 2.886 12.160 -22.395 79 TYR ATOM 1296 CA GLU 296 4.108 10.691 -25.713 80 PHE ATOM 1297 CA ILE 297 6.176 8.324 -27.783 81 ASN ATOM 1298 CA HIS 298 6.549 9.092 -31.509 82 ILE ATOM 1299 CA SER 299 8.143 7.333 -34.465 83 ARG ATOM 1300 CA MET 300 9.679 9.079 -37.440 84 PHE ATOM 1301 CA LEU 301 10.408 7.138 -40.629 85 SER ATOM 1302 CA VAL 302 11.315 8.916 -43.898 86 PRO ATOM 1303 CA ILE 303 10.725 6.833 -47.052 87 PHE ATOM 1304 CA PRO 304 11.083 6.781 -50.848 88 ARG ATOM 1305 CA LEU 305 8.825 5.854 -53.800 89 ASN ATOM 1306 CA TRP 306 10.358 2.848 -55.607 90 ALA ATOM 1307 CA GLU 307 9.013 3.938 -59.020 91 LYS ATOM 1308 CA LYS 308 10.898 7.247 -58.615 92 THR ATOM 1309 CA GLY 309 13.241 6.241 -55.765 93 GLN ATOM 1310 CA VAL 310 13.494 9.946 -54.975 94 LEU ATOM 1311 CA VAL 311 13.633 11.661 -51.571 95 LEU ATOM 1312 CA THR 312 9.875 11.345 -51.093 96 GLU ATOM 1313 CA GLY 313 8.061 11.677 -47.708 97 GLY ATOM 1314 CA THR 314 8.113 11.142 -43.928 98 VAL ATOM 1315 CA LEU 315 6.136 8.687 -41.825 99 ILE ATOM 1316 CA LYS 316 5.332 9.797 -38.320 100 ILE ATOM 1317 CA ILE 317 3.950 6.939 -36.242 101 THR ATOM 1318 CA TYR 318 2.471 7.497 -32.799 102 ILE ATOM 1319 CA TYR 319 1.980 4.946 -30.040 103 ASP ATOM 1320 CA CYS 320 -1.010 5.405 -27.699 104 ASP ATOM 1321 CA HIS 321 8.930 4.052 -9.873 116 LYS ATOM 1322 CA ALA 322 8.358 7.602 -8.550 117 ARG ATOM 1323 CA HIS 323 6.355 6.397 -5.483 118 ARG ATOM 1324 CA GLN 324 9.550 4.509 -4.640 119 GLU ATOM 1325 CA ILE 325 11.703 7.526 -5.567 120 ARG ATOM 1326 CA THR 326 10.160 9.387 -2.615 121 LEU ATOM 1327 CA SER 327 11.645 6.928 -0.148 122 SER ATOM 1328 CA SER 328 15.338 7.212 -1.076 123 ILE ATOM 1329 CA LEU 329 14.903 10.970 -1.407 124 LEU ATOM 1330 CA GLN 330 14.184 10.701 2.321 125 GLY ATOM 1331 CA GLU 331 17.034 8.770 3.932 126 GLU ATOM 1332 CA MET 332 19.482 10.074 1.335 127 MET ATOM 1333 CA ALA 333 18.062 13.623 1.266 128 THR ATOM 1334 CA VAL 334 19.100 13.557 4.911 129 ALA ATOM 1335 CA GLY 335 22.335 11.517 4.794 130 ARG ATOM 1336 CA LEU 336 23.645 13.675 1.918 131 VAL ATOM 1337 CA SER 337 22.042 16.953 2.990 132 ALA ATOM 1338 CA GLN 338 24.575 16.400 5.752 133 HIS ATOM 1339 CA ILE 339 27.458 16.232 3.249 134 GLU ATOM 1340 CA ILE 340 26.264 19.742 2.379 135 ILE ATOM 1341 CA SER 341 27.081 21.605 5.602 136 ARG ATOM 1342 CA THR 342 30.481 19.952 5.903 137 ASN ATOM 1343 CA GLN 343 32.261 22.032 3.268 138 PRO ATOM 1344 CA LEU 344 29.595 24.747 3.865 139 ILE ATOM 1345 CA GLU 345 30.971 25.320 7.365 140 THR ATOM 1346 CA VAL 346 34.462 25.555 5.817 141 ILE ATOM 1347 CA SER 347 33.650 27.898 2.900 142 ILE ATOM 1348 CA ARG 348 31.379 30.041 5.079 143 GLY ATOM 1349 CA ALA 349 33.875 29.618 7.926 144 GLY ATOM 1350 CA GLU 350 36.847 30.930 5.942 145 PHE ATOM 1351 CA GLN 351 34.784 34.053 5.125 146 ILE ATOM 1352 CA LEU 352 34.736 34.556 8.912 147 MET ATOM 1353 CA ARG 353 38.508 33.847 8.851 148 ARG ATOM 1354 CA GLU 354 40.042 35.692 5.870 149 MET ATOM 1355 CA MET 355 38.173 38.966 6.523 150 LYS ATOM 1356 CA ALA 356 40.325 40.183 9.461 151 LYS ATOM 1357 CA ASN 357 43.928 40.252 8.108 152 HIS ATOM 1358 CA LYS 358 43.224 42.363 6.143 153 LEU ATOM 1359 CA ALA 359 44.304 41.457 2.582 154 ASP ATOM 1360 CA GLU 360 46.673 38.473 2.607 155 ASP ATOM 1361 CA LEU 361 49.794 38.045 0.375 156 PRO ATOM 1362 CA ARG 362 47.352 36.673 -2.270 157 GLU ATOM 1363 CA ALA 363 48.246 33.083 -1.234 158 THR ATOM 1364 CA LEU 364 44.701 32.828 0.174 159 LEU ATOM 1378 CA ASN 378 43.181 32.204 -3.267 160 LYS ATOM 1379 CA ALA 379 44.132 28.552 -3.898 161 LYS ATOM 1380 CA ILE 380 42.861 27.559 -0.435 162 TYR ATOM 1381 CA SER 381 39.678 29.652 -0.900 163 ILE ATOM 1382 CA SER 382 38.502 28.898 -4.453 164 ASN ATOM 1383 CA SER 383 39.347 25.164 -4.727 165 ILE ATOM 1384 CA ILE 384 37.752 24.255 -1.350 166 ILE ATOM 1385 CA ARG 385 34.775 26.397 -2.395 167 THR ATOM 1386 CA LEU 386 35.024 24.651 -5.772 168 ASN ATOM 1387 CA ASN 387 35.076 21.077 -4.428 169 GLU ATOM 1388 CA PRO 388 31.646 21.598 -2.842 170 LEU ATOM 1389 CA ASP 389 30.456 23.563 -5.892 171 SER ATOM 1390 CA THR 390 30.739 20.614 -8.317 172 ARG ATOM 1391 CA ALA 391 29.383 18.520 -5.462 173 LEU ATOM 1392 CA ARG 392 26.406 20.895 -5.529 174 GLU ATOM 1393 CA GLN 393 26.359 20.007 -9.210 175 THR ATOM 1394 CA LEU 394 26.741 16.249 -8.558 176 ILE ATOM 1395 CA ILE 395 23.958 16.858 -6.009 177 VAL ATOM 1396 CA PHE 396 21.528 18.891 -8.113 178 LYS ATOM 1397 CA ASN 397 22.350 16.374 -10.871 179 GLU ATOM 1398 CA LEU 398 20.976 13.729 -8.515 180 ILE ATOM 1399 CA SER 399 18.105 16.092 -7.686 181 LEU ATOM 1400 CA ARG 400 17.333 15.868 -11.387 182 GLU ATOM 1401 CA TYR 401 16.921 12.127 -10.900 183 TYR ATOM 1402 CA LEU 402 13.623 13.002 -9.199 184 SER ATOM 1403 CA ARG 403 12.094 15.759 -11.360 185 LYS ATOM 1404 CA TYR 404 12.277 14.421 -14.964 186 GLU ATOM 1407 CA GLU 407 10.679 11.206 -16.368 187 ARG ATOM 1408 CA LEU 408 12.922 13.348 -22.492 188 VAL ATOM 1409 CA LYS 409 14.352 10.214 -24.137 189 LEU ATOM 1410 CA ASP 410 15.742 10.467 -27.726 190 GLU ATOM 1411 CA ASP 411 16.825 7.336 -29.609 191 PHE ATOM 1412 CA GLU 412 19.138 7.580 -32.631 192 THR ATOM 1413 CA GLN 413 21.474 5.373 -34.674 193 GLU ATOM 1414 CA ILE 414 25.135 6.402 -34.632 194 PHE ATOM 1415 CA ASP 415 28.553 4.858 -34.419 195 ASN ATOM 1416 CA ILE 416 29.324 4.244 -30.782 196 LEU ATOM 1417 CA LYS 417 33.026 4.620 -31.230 197 ASN ATOM 1418 CA LYS 418 32.271 7.841 -33.098 198 GLU ATOM 1419 CA GLU 419 30.861 8.797 -29.765 199 LEU ATOM 1420 CA LEU 420 33.631 7.023 -27.814 200 ILE ATOM 1421 CA TYR 421 36.284 9.195 -29.413 201 ARG ATOM 1422 CA GLN 422 34.157 12.327 -29.243 202 GLU ATOM 1423 CA ILE 423 34.186 12.237 -25.476 203 VAL ATOM 1424 CA LYS 424 37.948 11.722 -25.045 204 TYR ATOM 1425 CA ASP 425 38.375 14.697 -27.382 205 VAL ATOM 1426 CA TYR 426 36.912 17.028 -24.755 206 LEU ATOM 1427 CA ILE 427 38.874 15.619 -21.788 207 PHE ATOM 1428 CA ALA 428 42.127 15.447 -23.777 208 GLU ATOM 1429 CA ILE 429 43.756 18.709 -22.584 209 GLU ATOM 1430 CA GLU 430 43.722 17.419 -18.991 210 LYS ATOM 1431 CA GLN 431 44.632 13.782 -19.698 211 ILE ATOM 1432 CA ALA 432 47.521 15.340 -21.574 212 ARG ATOM 1433 CA ARG 433 48.416 17.161 -18.332 213 LYS ATOM 1434 CA PHE 434 48.627 14.050 -16.117 214 MET ATOM 1435 CA GLY 435 50.924 12.267 -18.634 215 ASN ATOM 1436 CA ASP 436 48.496 9.337 -19.048 216 ILE ATOM 1437 CA LYS 437 49.249 6.147 -21.018 217 ASP ATOM 1438 CA LEU 438 45.696 6.172 -22.362 218 PHE ATOM 1439 CA THR 439 44.772 3.037 -24.324 219 CYS ATOM 1440 CA VAL 440 41.729 2.387 -26.535 220 PHE ATOM 1441 CA ILE 441 41.034 -0.905 -28.329 221 GLU ATOM 1442 CA TYR 442 38.067 -2.353 -30.262 222 THR ATOM 1443 CA ASP 443 37.583 -5.381 -32.517 223 ASP ATOM 1445 CA ASP 445 35.196 -3.314 -34.673 224 ASN ATOM 1446 CA GLU 446 35.419 0.201 -36.137 225 GLU ATOM 1447 CA GLU 447 31.895 -0.004 -37.591 226 ASP ATOM 1448 CA VAL 448 29.623 -0.121 -34.559 227 LEU ATOM 1449 CA ASN 449 26.139 1.384 -34.534 228 ARG ATOM 1450 CA CYS 450 23.430 1.569 -31.851 229 VAL ATOM 1451 CA CYS 451 19.863 2.798 -31.517 230 GLU ATOM 1452 CA ILE 452 19.895 4.872 -28.295 231 ALA ATOM 1453 CA PRO 453 19.935 8.401 -26.832 232 ASP ATOM 1454 CA SER 454 23.274 9.686 -28.034 233 ARG ATOM 1455 CA LEU 455 22.922 13.008 -26.180 234 THR ATOM 1456 CA LEU 456 22.577 10.837 -23.091 235 ARG ATOM 1457 CA ILE 457 24.580 7.614 -23.294 236 ILE ATOM 1458 CA GLN 458 27.025 10.473 -23.738 237 LYS ATOM 1459 CA PRO 459 26.919 11.508 -20.084 238 GLN ATOM 1460 CA LEU 460 27.373 7.829 -19.134 239 VAL ATOM 1461 CA VAL 461 30.788 7.904 -20.688 240 LEU ATOM 1462 CA GLU 462 31.668 11.371 -19.364 241 ILE ATOM 1463 CA ASN 463 31.145 9.713 -15.955 242 ASN ATOM 1464 CA ALA 464 32.886 6.505 -16.014 243 LEU ATOM 1465 CA ILE 465 35.778 8.409 -17.514 244 VAL ATOM 1466 CA VAL 466 35.426 11.225 -15.009 245 GLN ATOM 1467 CA HIS 467 36.110 8.779 -12.157 246 ASN ATOM 1468 CA GLY 468 38.709 6.620 -13.880 247 ALA ATOM 1469 CA ILE 469 40.425 9.982 -14.374 248 ILE ATOM 1470 CA GLN 470 41.828 10.686 -10.851 249 GLU ATOM 1471 CA PRO 471 40.881 7.169 -9.673 250 ALA ATOM 1472 CA CYS 472 44.143 6.313 -11.444 251 THR ATOM 1473 CA LYS 473 45.401 9.923 -11.420 252 GLY ATOM 1474 CA GLY 474 49.070 10.908 -11.641 253 GLU ATOM 1475 CA LYS 475 51.081 8.772 -14.081 254 ASN ATOM 1476 CA GLY 476 47.926 6.649 -14.197 255 GLY ATOM 1477 CA VAL 477 46.405 4.629 -17.036 256 LYS ATOM 1478 CA VAL 478 42.905 4.391 -18.516 257 ILE ATOM 1479 CA THR 479 41.795 1.669 -20.969 258 LYS ATOM 1480 CA ILE 480 38.575 1.955 -23.008 259 ILE ATOM 1481 CA SER 481 37.072 -1.061 -24.754 260 THR ATOM 1482 CA VAL 482 34.093 -1.364 -27.115 261 SER ATOM 1483 CA ALA 483 33.498 -4.992 -28.109 262 GLU ATOM 1484 CA GLU 484 30.816 -5.957 -30.622 263 ASP ATOM 1485 CA CYS 485 28.558 -8.888 -29.774 264 MET ATOM 1486 CA GLY 486 25.904 -10.266 -32.169 265 TYR ATOM 1487 CA ASN 487 22.990 -8.421 -30.493 266 THR ATOM 1488 CA ARG 488 24.621 -6.195 -27.855 267 LYS ATOM 1489 CA VAL 489 27.700 -3.995 -27.227 268 VAL ATOM 1490 CA ARG 490 30.103 -3.785 -24.257 269 ARG ATOM 1491 CA ILE 491 31.917 -0.579 -23.330 270 VAL ATOM 1492 CA ALA 492 34.401 -0.806 -20.470 271 SER ATOM 1493 CA VAL 493 36.685 1.759 -18.794 272 VAL ATOM 1494 CA ARG 494 39.509 0.034 -16.901 273 TRP ATOM 1495 CA ASP 495 41.920 1.991 -14.752 274 ASN ATOM 1496 CA THR 496 44.703 0.889 -12.419 275 SER ATOM 1497 CA GLY 497 45.542 1.259 -8.719 276 GLY ATOM 1498 CA HIS 498 43.030 0.721 -5.871 277 PRO ATOM 1499 CA GLY 499 40.210 -1.740 -6.722 278 PRO ATOM 1500 CA ILE 500 36.978 -2.007 -4.683 279 ILE ATOM 1501 CA ASP 501 35.919 -5.127 -2.712 280 PRO ATOM 1502 CA PRO 502 33.130 -7.747 -2.908 281 GLU ATOM 1503 CA LYS 503 30.734 -5.590 -0.848 282 GLU ATOM 1504 CA VAL 504 30.824 -2.520 -3.110 283 LEU ATOM 1505 CA ILE 505 30.042 -4.539 -6.282 284 LYS ATOM 1506 CA GLU 506 26.536 -3.130 -5.938 285 GLU ATOM 1507 CA ARG 507 26.760 -0.896 -2.816 286 LYS ATOM 1508 CA VAL 508 28.122 2.130 -4.739 287 ILE ATOM 1509 CA GLU 509 25.096 1.963 -7.059 288 PHE ATOM 1510 CA ALA 510 22.722 3.738 -4.622 289 SER ATOM 1511 CA ASN 511 23.455 7.559 -4.373 290 PRO ATOM 1512 CA GLU 512 26.600 6.898 -2.187 291 PHE ATOM 1515 CA GLY 515 30.008 8.557 -2.745 292 PHE ATOM 1516 CA ASN 516 33.646 7.553 -1.925 293 THR ATOM 1517 CA LYS 517 36.893 8.726 -0.208 294 THR ATOM 1518 CA ILE 518 32.121 9.605 -6.748 295 LEU ATOM 1519 CA GLY 519 28.273 9.672 -7.315 296 GLY ATOM 1520 CA LEU 520 27.288 7.018 -9.847 297 LEU ATOM 1521 CA LEU 521 23.591 7.071 -9.179 298 SER ATOM 1522 CA ASN 522 22.009 8.353 -12.469 299 ILE ATOM 1523 CA VAL 523 24.500 6.282 -14.367 300 CYS ATOM 1524 CA HIS 524 22.831 3.234 -12.910 301 ARG ATOM 1525 CA HIS 525 19.317 4.063 -14.205 302 LYS ATOM 1526 CA ARG 526 20.661 5.575 -17.438 303 ILE ATOM 1527 CA VAL 527 21.959 2.289 -18.824 304 ILE ATOM 1528 CA LYS 528 19.918 0.137 -16.437 305 GLU ATOM 1529 CA LEU 529 16.408 1.662 -16.593 306 ASP ATOM 1530 CA LEU 530 16.401 4.120 -19.532 307 GLU ATOM 1531 CA TYR 531 17.911 2.003 -22.347 308 HIS ATOM 1532 CA GLY 532 17.944 -1.216 -20.357 309 GLY ATOM 1533 CA GLU 533 20.881 -3.525 -19.655 310 GLY ATOM 1534 CA GLY 534 23.618 -3.194 -17.033 311 LYS ATOM 1535 CA LEU 535 26.355 -0.795 -15.891 312 ILE ATOM 1536 CA HIS 536 28.216 -2.927 -13.249 313 TRP ATOM 1537 CA ILE 537 31.960 -3.166 -12.327 314 THR ATOM 1538 CA ARG 538 34.725 -5.556 -11.228 315 GLU ATOM 1539 CA ARG 539 38.320 -5.739 -10.024 316 ASN ATOM 1540 CA LEU 540 41.197 -6.836 -12.296 317 ARG ATOM 1541 CA GLU 541 44.882 -6.359 -13.210 318 GLU ATOM 1542 CA PRO 542 45.499 -4.426 -9.982 319 ASN ATOM 1543 CA GLY 543 42.723 -1.965 -10.983 320 GLY ATOM 1544 CA THR 544 38.971 -1.659 -11.693 321 VAL ATOM 1545 CA GLU 545 36.715 -1.464 -14.762 322 VAL ATOM 1546 CA ILE 546 33.331 0.205 -15.512 323 PHE ATOM 1547 CA ALA 547 31.238 -1.923 -17.937 324 ILE ATOM 1548 CA PHE 548 27.804 -1.604 -19.533 325 PHE ATOM 1549 CA TYR 549 25.801 -3.470 -22.162 326 GLU ATOM 1550 CA ILE 550 22.863 -2.261 -24.266 327 ILE ATOM 1551 CA PRO 551 21.419 -4.066 -27.298 328 PRO ATOM 1552 CA ASN 552 21.654 -2.156 -30.582 329 LYS ATOM 1553 CA GLN 553 17.870 -1.901 -30.988 330 THR ATOM 1554 CA ARG 554 15.853 -1.243 -27.785 331 PRO ATOM 1555 CA THR 555 12.926 -2.577 -29.808 332 GLU ATOM 1556 CA PRO 556 14.052 -5.825 -28.144 333 LYS ATOM 1557 CA VAL 557 12.475 -5.484 -24.669 334 ARG TER