ATOM 1001 CA MET 1 -22.481 112.584 29.613 151 ARG ATOM 1002 CA GLU 2 -19.345 111.740 31.527 152 TRP ATOM 1003 CA LEU 3 -16.874 113.100 28.946 153 ILE ATOM 1004 CA LEU 4 -18.565 116.496 28.732 154 GLY ATOM 1005 CA SER 5 -18.562 116.573 32.512 155 GLU ATOM 1006 CA GLU 6 -14.884 115.796 32.864 156 LEU ATOM 1007 CA TYR 7 -13.801 118.319 30.293 157 TRP ATOM 1008 CA GLY 8 -16.052 120.876 31.902 158 GLN ATOM 1009 CA LEU 9 -14.354 120.014 35.183 159 ASN ATOM 1010 CA PHE 10 -10.991 120.582 33.453 160 TYR ATOM 1011 CA LEU 11 -11.950 124.002 32.166 161 LEU ATOM 1012 CA ALA 12 -13.574 125.074 35.464 162 ASN ATOM 1013 CA LYS 13 -10.450 123.992 37.360 163 THR ATOM 1014 CA ILE 14 -8.095 125.846 35.010 164 VAL ATOM 1015 CA VAL 15 -10.278 128.954 34.766 165 ALA ATOM 1016 CA THR 16 -10.344 129.138 38.571 166 ALA ATOM 1017 CA VAL 17 -5.918 131.334 36.109 168 ARG ATOM 1018 CA VAL 18 -8.684 133.694 37.146 169 GLN ATOM 1019 CA LEU 19 -10.056 133.870 33.614 170 ILE ATOM 1020 CA ALA 20 -13.304 132.542 32.251 171 PRO ATOM 1021 CA ILE 21 -13.435 128.904 31.142 172 ALA ATOM 1022 CA ALA 22 -14.211 130.104 27.591 173 GLU ATOM 1023 CA ALA 23 -11.032 132.128 27.653 174 GLN ATOM 1024 CA ILE 24 -8.890 129.099 28.650 175 VAL ATOM 1025 CA ALA 25 -10.440 127.168 25.717 176 PHE ATOM 1026 CA ALA 26 -12.590 129.169 23.212 177 PRO ATOM 1027 CA ILE 27 -13.442 126.134 21.070 178 GLY ATOM 1028 CA ILE 28 -11.764 125.089 17.845 179 ALA ATOM 1029 CA VAL 29 -13.177 128.103 16.079 180 GLN ATOM 1030 CA ASN 30 -12.168 130.699 18.663 181 GLY ATOM 1031 CA VAL 31 -8.669 129.347 18.841 182 LEU ATOM 1032 CA ALA 32 -8.286 129.579 15.071 183 LEU ATOM 1033 CA GLN 33 -9.428 133.188 15.309 184 GLU ATOM 1034 CA ARG 34 -7.111 133.992 18.177 185 GLY ATOM 1035 CA ASN 35 -4.124 132.309 16.503 186 LEU ATOM 1036 CA LYS 36 -4.738 134.056 13.207 187 THR ATOM 1037 CA ARG 37 -4.618 137.431 15.082 188 LYS ATOM 1038 CA GLN 38 -1.190 136.396 16.179 189 THR ATOM 1039 CA ARG 39 0.284 135.025 12.887 190 GLY ATOM 1040 CA GLY 40 0.442 131.560 14.478 191 GLY ATOM 1046 CA ASN 46 2.563 132.708 17.436 192 ASP ATOM 1047 CA LEU 47 1.054 130.267 19.902 193 THR ATOM 1048 CA SER 48 3.248 131.753 22.661 194 ALA ATOM 1049 CA GLU 49 1.861 135.239 22.072 195 LYS ATOM 1050 CA GLN 50 -1.638 133.682 22.187 196 TYR ATOM 1051 CA TYR 51 -0.830 132.139 25.546 197 ALA ATOM 1052 CA LYS 52 0.507 135.426 26.963 198 LEU ATOM 1053 CA GLU 53 -2.361 137.583 25.642 199 GLU ATOM 1054 CA MET 54 -5.199 135.346 26.793 200 ASN ATOM 1057 CA GLU 57 -3.437 134.834 30.055 201 LYS ATOM 1058 CA LEU 58 -2.831 131.108 29.957 202 LEU ATOM 1059 CA ALA 59 0.701 132.085 30.877 203 VAL ATOM 1060 CA ALA 60 2.543 134.943 32.676 204 ASP ATOM 1061 CA ALA 61 5.972 135.367 30.942 205 ALA ATOM 1062 CA LEU 62 7.831 134.254 27.777 206 LEU ATOM 1063 CA MET 63 11.558 133.483 28.208 207 ALA ATOM 1064 CA ASP 64 14.267 131.074 27.223 208 SER ATOM 1065 CA SER 65 15.716 128.413 29.485 209 SER ATOM 1066 CA HIS 66 18.598 130.778 30.300 210 ALA ATOM 1067 CA GLN 67 16.443 133.835 31.090 211 GLU ATOM 1068 CA GLN 68 14.232 131.595 33.228 212 ILE ATOM 1069 CA LYS 69 17.508 130.516 34.971 213 GLU ATOM 1070 CA GLN 70 18.389 134.105 35.772 214 LYS ATOM 1071 CA TRP 71 14.959 134.818 37.319 215 ALA ATOM 1072 CA HIS 72 14.835 131.623 39.334 216 LEU ATOM 1073 CA LYS 73 18.354 132.327 40.630 217 THR ATOM 1074 CA ALA 74 17.357 135.833 41.600 218 LYS ATOM 1075 CA GLN 75 14.482 134.212 43.467 219 GLU ATOM 1076 CA LYS 76 16.139 131.286 45.244 220 PHE ATOM 1077 CA LYS 77 19.800 132.364 45.179 221 GLY ATOM 1078 CA LYS 78 22.659 130.539 43.419 222 TRP ATOM 1079 CA HIS 79 24.711 127.492 44.338 223 SER ATOM 1080 CA LYS 80 28.427 128.057 43.714 224 LYS ATOM 1081 CA GLN 81 28.437 124.283 44.227 225 THR ATOM 1082 CA GLU 82 25.726 123.083 41.757 226 ASP ATOM 1083 CA ALA 83 26.148 125.976 39.332 227 LYS ATOM 1084 CA LYS 84 19.455 126.837 44.946 230 ARG ATOM 1085 CA ALA 85 17.118 123.762 44.642 231 ALA ATOM 1086 CA ALA 86 16.720 120.022 45.528 232 ILE ATOM 1087 CA LYS 87 14.944 117.449 43.395 233 SER ATOM 1088 CA ALA 88 11.767 115.701 44.472 234 TYR ATOM 1089 CA LYS 89 13.636 112.403 43.931 235 TYR ATOM 1090 CA ALA 90 16.493 113.358 46.252 236 ASP ATOM 1091 CA LYS 91 14.303 115.164 48.840 237 TYR ATOM 1092 CA LEU 92 14.172 113.211 52.118 238 ALA ATOM 1093 CA GLY 93 10.467 112.639 52.829 239 LEU ATOM 1094 CA GLU 94 10.272 111.877 56.575 240 LYS ATOM 1095 CA VAL 95 8.676 108.599 57.598 241 THR ATOM 1096 CA ALA 96 5.782 109.434 59.978 242 PRO ATOM 1097 CA THR 97 6.092 108.484 63.691 243 ALA ATOM 1098 CA ASP 98 4.551 105.235 64.982 244 ASP ATOM 1099 CA SER 99 1.598 105.938 67.262 245 THR ATOM 1100 CA LYS 100 -0.156 102.665 68.328 246 GLY ATOM 1101 CA PRO 101 -3.329 103.030 66.254 247 ASP ATOM 1102 CA ARG 102 -3.405 102.705 62.530 248 SER ATOM 1103 CA VAL 103 -5.606 103.157 59.557 249 ILE ATOM 1104 CA TRP 104 -4.545 100.628 56.960 250 GLY ATOM 1105 CA VAL 105 -4.585 101.553 53.327 251 VAL ATOM 1106 CA LEU 106 -5.175 98.815 50.786 252 VAL ATOM 1107 CA ASP 107 -4.873 99.549 47.064 253 PHE ATOM 1108 CA PHE 108 -7.174 98.296 44.349 254 ALA ATOM 1109 CA LYS 109 -5.052 99.543 41.481 255 ASN ATOM 1110 CA GLY 110 -5.587 98.091 38.019 256 GLY ATOM 1111 CA SER 111 -7.741 95.407 36.326 257 ALA ATOM 1112 CA MET 112 -9.178 92.789 38.673 258 ILE ATOM 1113 CA ASP 113 -8.160 85.917 39.635 259 ASP ATOM 1114 CA ALA 114 -4.580 84.997 40.286 260 GLY ATOM 1115 CA HIS 115 -2.451 87.123 42.493 261 GLU ATOM 1116 CA GLU 116 -0.673 90.439 41.985 262 GLU ATOM 1117 CA VAL 117 0.399 90.322 38.351 263 THR ATOM 1118 CA ASN 118 1.728 92.822 35.779 264 GLN ATOM 1119 CA SER 119 -4.912 89.896 42.055 268 GLY ATOM 1120 CA LEU 120 -7.998 88.851 44.043 269 GLY ATOM 1121 CA ARG 121 -6.022 86.671 46.404 270 ASP ATOM 1122 CA GLU 122 -3.263 89.187 47.173 271 THR ATOM 1123 CA GLU 123 -5.690 91.968 47.904 272 THR ATOM 1124 CA ILE 124 -8.014 89.751 49.970 273 ALA ATOM 1125 CA THR 125 -4.899 88.766 51.950 274 ALA ATOM 1126 CA ALA 126 -3.943 92.376 52.545 275 GLN ATOM 1127 CA VAL 127 -7.473 93.205 53.716 276 ILE ATOM 1128 CA LEU 128 -7.273 90.011 55.875 277 ARG ATOM 1129 CA ALA 129 -3.925 91.037 57.377 278 ASP ATOM 1130 CA ALA 130 -5.421 94.415 58.319 279 ALA ATOM 1131 CA PHE 131 -8.690 93.034 59.689 280 ARG ATOM 1132 CA LYS 132 -5.268 94.584 66.389 283 PRO ATOM 1133 CA PRO 133 -3.345 97.851 65.679 284 LYS ATOM 1134 CA GLN 134 -5.502 98.497 62.519 285 VAL ATOM 1135 CA ASP 135 -8.547 100.516 63.571 286 LYS ATOM 1136 CA GLN 136 -10.183 101.179 60.192 287 ALA ATOM 1137 CA VAL 137 -9.559 100.315 56.511 288 ILE ATOM 1138 CA VAL 138 -9.390 102.492 53.437 289 VAL ATOM 1139 CA LEU 139 -9.700 100.564 50.229 290 LEU ATOM 1140 CA ARG 140 -8.101 102.910 47.634 291 ARG ATOM 1141 CA LEU 141 -9.645 102.152 44.303 292 VAL ATOM 1142 CA GLU 142 -8.491 102.804 40.773 293 ASN ATOM 1143 CA SER 143 -9.950 99.944 38.775 294 SER ATOM 1144 CA PRO 144 -11.853 99.592 35.540 295 PRO ATOM 1145 CA GLY 145 -13.159 96.252 36.720 296 GLY ATOM 1146 CA GLY 146 -12.377 92.626 35.935 297 GLY ATOM 1147 CA MET 147 -13.258 89.110 37.024 298 SER ATOM 1148 CA VAL 148 -16.548 88.877 38.972 299 VAL ATOM 1149 CA HIS 149 -15.227 85.984 41.096 300 THR ATOM 1150 CA GLY 150 -12.068 87.979 41.949 301 ALA ATOM 1151 CA TYR 151 -14.314 90.858 42.875 302 SER ATOM 1152 CA GLY 152 -16.186 88.523 45.203 303 GLU ATOM 1153 CA LEU 153 -13.101 87.234 46.861 304 VAL ATOM 1154 CA ALA 154 -12.281 90.844 47.668 305 ILE ATOM 1155 CA ALA 155 -15.743 91.900 48.711 306 ARG ATOM 1156 CA SER 156 -16.144 89.018 51.190 307 ALA ATOM 1157 CA GLN 157 -12.983 89.918 52.994 308 GLU ATOM 1158 CA LEU 158 -13.896 93.520 53.226 309 LEU ATOM 1159 CA GLN 159 -17.372 92.641 54.419 310 ALA ATOM 1160 CA ARG 160 -15.693 90.298 56.960 311 ALA ATOM 1161 CA LEU 161 -13.637 93.221 58.271 312 ALA ATOM 1162 CA ARG 162 -16.710 95.398 58.699 313 ARG ATOM 1163 CA ASP 163 -18.627 92.627 60.514 314 ALA ATOM 1164 CA LYS 164 -15.654 92.274 62.869 315 ALA ATOM 1165 CA ASN 165 -15.969 95.908 64.024 316 GLY ATOM 1166 CA ILE 166 -13.412 97.611 61.653 317 LYS ATOM 1167 CA PRO 167 -14.738 100.617 59.669 318 PRO ATOM 1168 CA LEU 168 -14.197 100.402 55.923 319 VAL ATOM 1169 CA THR 169 -14.013 103.516 53.723 320 VAL ATOM 1170 CA VAL 170 -13.574 103.528 49.934 321 VAL ATOM 1171 CA THR 171 -11.414 106.259 48.254 322 SER ATOM 1174 CA LYS 174 -9.348 107.814 42.714 323 GLY ATOM 1175 CA VAL 175 -9.646 107.899 38.951 324 GLY ATOM 1176 CA ALA 176 -13.888 102.505 40.334 325 ALA ATOM 1177 CA ALA 177 -16.337 100.876 37.935 326 ALA ATOM 1178 CA SER 178 -17.981 97.480 37.283 327 SER ATOM 1179 CA GLY 179 -15.832 95.192 39.478 328 GLY ATOM 1180 CA GLY 180 -14.447 98.510 40.780 329 GLY ATOM 1181 CA TYR 181 -17.856 99.267 42.281 330 TYR ATOM 1182 CA MET 182 -18.496 95.634 43.299 331 TRP ATOM 1183 CA MET 183 -15.499 95.523 45.600 332 ILE ATOM 1184 CA ALA 184 -16.481 98.929 47.012 333 SER ATOM 1185 CA CYS 185 -19.979 97.864 47.987 334 THR ATOM 1186 CA VAL 186 -19.481 96.740 51.503 335 PRO ATOM 1187 CA ALA 187 -18.045 100.105 52.617 336 ALA ATOM 1188 CA ASP 188 -19.550 102.135 55.515 337 ASN ATOM 1189 CA LYS 189 -18.729 105.174 53.347 338 TYR ATOM 1190 CA ILE 190 -17.766 105.652 49.671 339 ILE ATOM 1191 CA VAL 191 -16.111 108.955 48.656 340 VAL ATOM 1192 CA SER 192 -15.386 109.875 44.976 341 ALA ATOM 1193 CA ALA 193 -13.776 112.718 43.035 342 ASN ATOM 1194 CA PRO 194 -16.397 114.498 40.940 343 PRO ATOM 1195 CA PHE 195 -14.140 113.338 38.084 344 SER ATOM 1196 CA ALA 196 -14.031 109.676 39.064 345 THR ATOM 1197 CA ILE 197 -15.628 107.246 36.708 346 LEU ATOM 1198 CA VAL 198 -17.785 104.828 38.495 347 THR ATOM 1199 CA GLY 199 -20.838 102.698 38.362 348 GLY ATOM 1200 CA SER 200 -21.135 100.665 35.213 349 SER ATOM 1201 CA ILE 201 -23.208 98.131 37.207 350 ILE ATOM 1202 CA GLY 202 -23.589 95.323 34.729 351 GLY ATOM 1203 CA VAL 203 -22.183 92.184 33.237 352 ILE ATOM 1204 CA VAL 204 -20.959 90.531 30.027 353 PHE ATOM 1205 CA ALA 205 -19.163 87.497 28.672 354 GLY ATOM 1206 CA GLN 206 -17.865 87.018 25.096 355 VAL ATOM 1207 CA MET 207 -17.293 83.757 23.174 356 ILE ATOM 1208 CA PRO 208 -15.861 83.511 19.688 357 THR ATOM 1209 CA ASN 209 -15.559 80.317 17.726 358 THR ATOM 1210 CA PHE 210 -13.875 80.000 14.344 359 VAL ATOM 1211 CA ASN 211 -15.584 76.888 12.964 360 GLU ATOM 1212 CA ARG 212 -16.656 78.586 9.754 361 ASN ATOM 1213 CA PHE 213 -13.345 80.486 9.592 362 SER ATOM 1214 CA LEU 214 -11.385 77.182 9.524 363 LEU ATOM 1215 CA LYS 215 -13.963 75.564 7.226 364 ASP ATOM 1216 CA SER 216 -13.246 78.024 4.358 365 SER ATOM 1217 CA LYS 217 -9.513 77.147 4.470 366 ILE ATOM 1218 CA ASP 218 -10.347 73.412 4.381 367 GLY ATOM 1219 CA ILE 219 -9.751 72.721 8.075 368 VAL ATOM 1220 CA ASP 220 -12.385 70.860 10.089 369 HIS ATOM 1221 CA ILE 221 -12.968 69.403 13.550 370 THR ATOM 1222 CA GLU 222 -14.586 66.200 14.647 371 ASP ATOM 1223 CA LEU 223 -14.969 64.331 17.884 372 GLY ATOM 1224 CA HIS 224 -17.349 62.457 20.142 373 VAL ATOM 1225 CA THR 225 -18.908 63.906 23.288 374 SER ATOM 1226 CA ALA 226 -20.855 62.515 26.188 375 THR ATOM 1227 CA GLY 227 -22.940 65.737 26.341 376 SER ATOM 1228 CA GLN 228 -23.268 68.857 24.135 377 PRO ATOM 1229 CA TYR 229 -22.254 70.774 27.348 378 LEU ATOM 1230 CA LYS 230 -18.734 69.267 27.008 379 ALA ATOM 1231 CA ARG 231 -18.226 70.213 23.451 380 ASP ATOM 1233 CA LEU 233 -17.184 73.830 23.894 381 VAL ATOM 1234 CA THR 234 -13.937 75.243 22.446 382 SER ATOM 1235 CA LEU 235 -12.576 77.808 20.040 383 ILE ATOM 1236 CA LEU 236 -12.750 75.573 16.906 384 THR ATOM 1237 CA GLY 237 -16.275 74.118 17.419 385 ARG ATOM 1238 CA GLU 238 -19.719 75.737 17.095 386 ALA ATOM 1239 CA ASN 239 -21.087 76.644 20.543 387 LEU ATOM 1240 CA THR 240 -23.984 74.243 21.258 388 PRO ATOM 1241 CA GLU 241 -27.379 75.851 22.091 389 PRO ATOM 1242 CA GLU 242 -27.331 73.905 25.347 390 GLU ATOM 1243 CA GLY 243 -24.089 75.661 26.212 391 ALA ATOM 1244 CA ARG 244 -25.559 79.027 25.122 392 GLN ATOM 1247 CA PHE 247 -28.538 78.660 27.438 393 LEU ATOM 1248 CA ARG 248 -27.177 83.258 29.337 394 GLN ATOM 1249 CA GLU 249 -28.479 82.140 32.735 395 LEU ATOM 1250 CA GLU 250 -25.103 82.476 34.349 396 SER ATOM 1251 CA LEU 251 -25.057 86.107 33.222 397 ILE ATOM 1252 CA ASN 252 -28.755 86.902 33.841 398 GLU ATOM 1253 CA GLU 253 -27.929 85.824 37.273 399 ASN ATOM 1254 CA THR 254 -24.606 87.520 38.011 400 GLY ATOM 1255 CA HIS 255 -26.643 90.639 37.232 401 TYR ATOM 1256 CA GLN 256 -29.185 89.726 39.895 402 LYS ATOM 1257 CA LEU 257 -26.254 89.102 42.136 403 ARG ATOM 1258 CA PHE 258 -24.823 92.603 41.294 404 PHE ATOM 1259 CA LYS 259 -27.949 94.692 41.609 405 ILE ATOM 1260 CA ASP 260 -28.747 92.808 44.875 406 THR ATOM 1261 CA PHE 261 -25.359 93.715 46.395 407 LEU ATOM 1262 CA VAL 262 -25.710 97.317 45.393 408 VAL ATOM 1263 CA LYS 263 -29.286 97.544 46.725 409 ALA ATOM 1264 CA ARG 264 -28.246 96.011 50.054 410 ASP ATOM 1265 CA MET 265 -25.174 98.255 50.451 411 ALA ATOM 1266 CA ARG 266 -26.962 101.463 49.299 412 ARG ATOM 1267 CA PRO 267 -34.175 97.869 46.218 415 THR ATOM 1268 CA SER 268 -33.421 95.750 43.085 416 PRO ATOM 1269 CA LEU 269 -36.103 97.545 40.962 417 GLU ATOM 1270 CA ASP 270 -34.598 100.917 42.034 418 GLN ATOM 1271 CA ILE 271 -30.963 100.034 41.252 419 ILE ATOM 1272 CA GLU 272 -31.838 98.658 37.838 420 ASP ATOM 1273 CA GLN 273 -33.230 102.111 37.025 421 LYS ATOM 1274 CA VAL 274 -29.633 103.420 37.286 422 ILE ATOM 1275 CA ALA 275 -27.466 100.368 36.702 423 ALA ATOM 1276 CA THR 276 -27.922 98.588 33.359 424 GLN ATOM 1277 CA GLY 277 -24.178 99.162 32.557 425 GLY ATOM 1278 CA GLU 278 -24.269 102.949 32.618 426 HIS ATOM 1279 CA HIS 279 -20.968 104.526 33.796 427 VAL ATOM 1280 CA TRP 280 -21.306 107.683 35.933 428 TRP ATOM 1281 CA TYR 281 -19.062 110.497 37.072 429 THR ATOM 1282 CA GLY 282 -18.481 110.621 40.796 430 GLY ATOM 1283 CA GLN 283 -20.953 113.463 40.737 431 GLN ATOM 1284 CA GLN 284 -23.801 111.649 38.964 432 ASP ATOM 1285 CA ALA 285 -23.092 108.782 41.399 433 ALA ATOM 1286 CA VAL 286 -23.399 110.956 44.472 434 LYS ATOM 1287 CA GLU 287 -26.559 112.322 42.918 435 ALA ATOM 1288 CA LYS 288 -28.173 108.885 42.467 436 ASN ATOM 1289 CA GLY 289 -26.993 107.389 45.807 437 GLY ATOM 1290 CA LEU 290 -24.166 105.180 44.599 438 LEU ATOM 1291 CA VAL 291 -21.482 107.295 46.256 439 VAL ATOM 1292 CA ASP 292 -21.797 108.995 49.721 440 ASP ATOM 1293 CA GLU 293 -19.682 112.157 49.285 441 SER ATOM 1294 CA ILE 294 -17.450 113.981 46.800 442 LEU ATOM 1295 CA ASN 295 -13.839 114.306 47.873 443 GLY ATOM 1296 CA THR 296 -10.383 112.833 47.952 444 ASP ATOM 1297 CA SER 297 -8.113 110.601 49.981 445 PHE ATOM 1298 CA ASP 298 -7.895 113.213 52.787 446 ASP ATOM 1299 CA GLU 299 -11.681 113.052 53.102 447 ASP ATOM 1300 CA VAL 300 -11.615 109.207 52.984 448 ALA ATOM 1301 CA ILE 301 -8.941 109.000 55.675 449 VAL ATOM 1302 CA LEU 302 -10.843 111.576 57.725 450 ALA ATOM 1303 CA SER 303 -14.087 109.517 57.657 451 LYS ATOM 1304 CA LEU 304 -12.130 106.393 58.689 452 ALA ATOM 1305 CA MET 305 -10.559 107.998 61.798 453 ALA ATOM 1306 CA GLU 306 -13.938 109.511 62.656 454 GLU ATOM 1307 CA GLY 307 -15.855 106.189 62.517 455 LEU ATOM 1308 CA ARG 308 -13.403 105.019 65.207 456 ALA ATOM 1309 CA GLU 309 -11.268 107.521 67.117 457 LYS ATOM 1310 CA VAL 310 -8.379 109.694 67.880 458 VAL ATOM 1311 CA VAL 311 -4.676 110.054 66.710 459 LYS ATOM 1312 CA ASN 312 -3.915 107.957 63.574 460 GLN ATOM 1313 CA VAL 313 -1.078 106.885 61.309 461 TRP ATOM 1314 CA ARG 314 -1.253 105.008 58.022 462 HIS ATOM 1315 CA TYR 315 -0.139 101.436 57.407 463 LEU ATOM 1316 CA MET 316 0.205 100.769 53.635 464 GLU ATOM 1317 CA GLN 317 -0.199 97.448 51.795 465 TYR TER