MetaGO result for job id PF12996

User Input

>UniRef100_L5JXA9/1-338 (338 residues)
MVNTGLAQASPLALANIGLAQVRALALASMGLDQVRALALDNTGLAQARPLALANMGLAQ
VRALVLANMGPGQASPLALANTGLAQASPLALVNTGLAQDRALALANMDLDQASHLASVN
MDLAQASPLALANTGLAQVRALALANMGLAQVRALPLATMGLDQASHLALVNMGLAQVRA
LPLATMGLDQANHLALVNMGLAQVRALPLATMGLDQANHLALANMGLAQVRALPLATMGL
DQANHLALVNMGLAQVRALPLATMGLDQANHLALVNMGLAQVRALPLATMGLDQANHLAL
VNMGLAQVRALPLATMGLDQANHLALVNMGLAQVRALP

Download query sequence and structure

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	2qj0A	0.39	7.17	0.053	0.710	Download
2	1t3tA2	0.39	6.77	0.040	0.675	Download
3	2uvfA	0.38	6.97	0.040	0.672	Download
4	3vstA	0.38	6.43	0.034	0.618	Download
5	1czfA	0.35	5.94	0.053	0.530	Download
6	1r9jB	0.32	7.00	0.085	0.580	Download
7	4fg5A	0.32	6.64	0.052	0.547	Download
8	1xnjB	0.31	6.72	0.055	0.541	Download
9	1rmgA	0.31	6.74	0.046	0.530	Download
10	1bheA1	0.30	6.30	0.056	0.503	Download

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0043169	0.03	cation binding
GO:0004872	0.02	receptor activity
GO:0019903	0.01	protein phosphatase binding
GO:0001875	0.01	lipopolysaccharide receptor activity
GO:0001530	0.01	lipopolysaccharide binding

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.13,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0044699	0.03	single-organism process
GO:0009987	0.03	cellular process
GO:0050896	0.02	response to stimulus
GO:0050794	0.02	regulation of cellular process
GO:0048584	0.02	positive regulation of response to stimulus
GO:0044763	0.02	single-organism cellular process
GO:2001013	0.01	epithelial cell proliferation involved in renal tubule morphogenesis
GO:2000331	0.01	regulation of terminal button organization
GO:1990268	0.01	response to gold nanoparticle
GO:1901215	0.01	negative regulation of neuron death

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.08,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0020036	0.01	Maurer's cleft
GO:0020003	0.01	symbiont-containing vacuole
GO:0005737	0.01	cytoplasm

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.14,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Reference:

Chengxin Zhang, Peter L Freddolino, and Yang Zhang. (2018) MetaGO: A Structure and Protein-Protein Interaction Network Based Pipeline for Automated Protein Function Annotations. Journal of Molecular Biology.

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