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COFACTOR result for job id 76658

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>76658 (99 residues)
MGIKLKILTPNGTFVENKEVDIINLKTIDGDIGVLANMAPFVTALRNDTLNFKEKNTYTY
IHVDQGLVVISKNQCKIITENLYLVDKQDRELPTPLKLA

Download query sequence and structure

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	2e5yA	0.95	0.76	0.214	0.990	Download
2	1aqtA	0.90	1.24	0.133	0.990	Download
3	2qe7H	0.90	1.22	0.245	0.990	Download
4	6fkfe	0.90	1.29	0.276	0.990	Download
5	5yioA	0.85	1.75	0.184	0.990	Download
6	6f5dH	0.83	1.86	0.172	0.990	Download
7	1e79H	0.82	1.74	0.189	0.960	Download
8	2rq7A	0.80	2.09	0.194	0.990	Download
9	5lqxH	0.80	1.88	0.284	0.960	Download
10	2hldH	0.78	1.75	0.247	0.899	Download

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0046933	1.00	proton-transporting ATP synthase activity, rotational mechanism
GO:1901363	0.67	heterocyclic compound binding
GO:0097159	0.67	organic cyclic compound binding
GO:0032559	0.66	adenyl ribonucleotide binding
GO:0005524	0.65	ATP binding

Download full result of the above consensus prediction.

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(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

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[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0015986	1.00	ATP synthesis coupled proton transport

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0098796	1.00	membrane protein complex
GO:0044424	1.00	intracellular part
GO:0045261	0.99	proton-transporting ATP synthase complex, catalytic core F(1)
GO:0044444	0.77	cytoplasmic part
GO:0045259	0.66	proton-transporting ATP synthase complex
GO:0044459	0.64	plasma membrane part
GO:0098797	0.61	plasma membrane protein complex
GO:0044446	0.61	intracellular organelle part
GO:0045260	0.58	plasma membrane proton-transporting ATP synthase complex
GO:0044429	0.52	mitochondrial part
GO:0016020	0.52	membrane
GO:0098800	0.50	inner mitochondrial membrane protein complex

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.336	2e5yA	0.952	0.76	0.214	0.990	3.6.3.14	9,26,33
2	0.203	1bshA	0.779	2.23	0.133	0.990	3.6.3.14	30,44
3	0.098	1zorA	0.479	4.13	0.080	0.818	1.1.1.42	68
4	0.060	1snzA	0.526	3.63	0.056	0.838	5.1.3.3	NA
5	0.060	1yq2A	0.531	3.54	0.070	0.808	3.2.1.23	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
1	0.06	2e5y0	0.952	0.76	0.214	0.990	0.95	III	Download	9,10,28,42,44,67,69,71,78,79,80
2	0.03	1fs00	0.773	1.21	0.122	0.818	0.76	III	Download	8,9,10,11,13,29,40,41,42,43,69,70,71,72
3	0.01	1o7dD	0.520	4.19	0.041	0.879	0.47	UUU	Download	33,34,35

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

[Download result.tar.bz2 for all prediction results]

Reference:

Chengxin Zhang, Peter L Freddolino, and Yang Zhang. COFACTOR: Improved protein function prediction by combining structure, sequence, and protein-protein interaction information. Nucleic Acids Research, 45: W291-299 (2017)
Ambrish Roy, Jianyi Yang, and Yang Zhang. COFACTOR: An accurate comparative algorithm for structure-based protein function annotation. Nucleic Acids Research, 40:W471-W477 (2012).

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