GLASS (GPCR-Ligand Association) database is a manually curated repository for experimentally-validated GPCR-ligand interactions. Along with relevant GPCR and chemical information, GPCR-ligand association data are extracted and integrated into GLASS from literature and public databases. (>>more about the GLASS database)
July 13, 2018:
Add TSV files for interaction data filtered (by Kd, Ki, IC50, EC50) for active and inactive compounds in 'Download' section.
July 12, 2018:
Replaced JMol viewer with NGL viewer. All GPCR structures are now loaded directly from GPCR-EXP, a new database we developed for experimentally-solved and predicted GPCR structures.
November 2, 2017:
Fixed bug in update script that missed BioLiP entries from 2015 and onwards.
October 4, 2017:
Fixed bug where searching with a ligand name as a query could result in an internal server error. Also fixed problem where synonym lists would not expand when clicked.
February 14, 2017:
Happy Valentine's Day! The browse ligand and browse family features have been fixed. Thank you to Hongjiu Zhang for assistance.
August 5, 2016:
Added 2D molecule structures to GPCR search results. Thank you to Dr. Andrew Horti for this useful suggestion. This change should hopefully facilitate the browsing of molecules.
June 24, 2016:
Fixed bug where DrugBank entries were not showing up.
March 1, 2015:
Redesigned the database schemas.
February 17, 2015:
Migrated the website to the new framework.
August 12, 2014:
Added searches for GPCR by family and for ligands by chemical structure.
June 30, 2014:
Added batch TSV and SDF download.
June 28, 2014:
Added synonyms for GPCRs and ligands, as well as Lipinski's rule of five check.
June 24, 2014:
Set up the database website.
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umich.edu
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