Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)
Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)
RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)
IDENa is the percentage sequence identity in the structurally aligned region.
(e)
Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.
Download full result of the above consensus prediction.
Click the graph to show a high resolution version.
(a)
CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b)
The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by CscoreGO:
Download full result of the above consensus prediction.
Click the graph to show a high resolution version.
(a)
CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b)
The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by CscoreGO:
Download full result of the above consensus prediction.
Click the graph to show a high resolution version.
(a)
CscoreGO is the confidence score of predicted GO terms. CscoreGO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b)
The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by CscoreGO:
Click on the radio buttons to visualize predicted active site residues.
(a)
CscoreEC is the confidence score for the Enzyme Commission (EC) number prediction. CscoreEC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)
TM-score is a measure of global structural similarity between query and template protein.
(c)
RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)
IDENa is the percentage sequence identity in the structurally aligned region.
(e)
Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
Click on the radio buttons to visualize predicted binding site and residues.
(a)
CscoreLB is the confidence score of predicted binding site. CscoreLB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)
BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)
TM-score is a measure of global structural similarity between query and template protein.
(d)
RMSDa the RMSD between residues that are structurally aligned by TM-align.
(e)
IDENa is the percentage sequence identity in the structurally aligned region.
(f)
Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
Chengxin Zhang, Peter L Freddolino, and Yang Zhang. COFACTOR: Improved protein function prediction by combining structure, sequence, and protein-protein interaction information. Nucleic Acids Research, 45: W291-299 (2017).
Ambrish Roy, Jianyi Yang, and Yang Zhang. COFACTOR: An accurate comparative algorithm for structure-based protein function annotation. Nucleic Acids Research, 40:W471-W477 (2012).