a An asterisk (*) marks a target if our free-text annotation (see below) matches neXtProt free text annotation. For each target, we manually assign a free-text annotation based on specific GO term predicted by our automatic I-TASSER/COFACTOR pipeline. b A plus (+) marks a target whose Fmax (see above) for either MF or BP is >0.5 Fmax for MF/BP quantitatively measures the consistency between COFACTOR predicted GO terms and neXtProt curated GO terms. "NA" means neXtProt did not assign GO term for a target.
a An asterisk (*) marks a target if our free-text annotation (see below) matches neXtProt free text annotation. A plus (+) marks a target whose Fmax (see above) for either MF or BP is >0.5 b For each target, we manually assign a free-text annotation based on specific GO term predicted by our automatic I-TASSER/COFACTOR pipeline. Additionally, we show, in a directed acyclic graph (DAG), the predicted GO terms used to calculate the Fmax. GO terms matching neXtProt annotations are colored in red. Root terms ("molecular_function" and "biological_process") and "protein binding" terms are not used to calculate Fmax, as per CAFA standard. Click on the image to get an enlarge version. If neXtProt did not assign GO terms, the DAG is not shown. Additionally, the I-TASSER structure model is available for download by clicking on the structure image. c Fmax for MF/BP quantitatively measures the consistency between COFACTOR predicted GO terms and neXtProt curated GO terms. "NA" means neXtProt did not assign GO term for a target. d neXtProt GO terms covered by I-TASSER/COFACTOR annotations are colored in red in the graph.
Q6ZW76-1 transferase acting on a protein Q96D15-1 catalytic activity, acting on a protein Q96II8-1 transferase acting on a proteinThe remaining interpretations for 35 out of all 44 targets (80%) are reasonably specific. These specific functions range from ubiquitin-protein transferase (A6NLU0-1, O75677-1) and phosphatidylinositol-4-phosphate phosphatase (Q5T0D9-1) to heat shock protein binding (O95801-1) and structural component of eye lens (Q8WXF5-1).
The targets are ranked in alphabetical order of the accession and separated by four-dollar ($$) signs. Information identical to this table is also provided in a zip file to facilitate programmatic parsing of the findings (GOterm.zip).
A6NI56-1 transferase acting on a protein ==== MF ==== * GO:0140096 0.50 catalytic activity, acting on a protein * GO:0016740 0.48 transferase activity ==== BP ==== GO:0009987 0.98 cellular process GO:0065007 0.81 biological regulation GO:0050789 0.78 regulation of biological process GO:0050794 0.77 regulation of cellular process GO:0051179 0.70 localization GO:0071840 0.68 cellular component organization or biogenesis GO:0016043 0.67 cellular component organization GO:0008152 0.63 metabolic process GO:0044237 0.61 cellular metabolic process GO:0048518 0.59 positive regulation of biological process GO:0071704 0.58 organic substance metabolic process GO:0048522 0.58 positive regulation of cellular process GO:0044238 0.57 primary metabolic process GO:0051128 0.56 regulation of cellular component organization GO:0043170 0.56 macromolecule metabolic process GO:0006807 0.56 nitrogen compound metabolic process GO:1901564 0.52 organonitrogen compound metabolic process GO:0044260 0.51 cellular macromolecule metabolic process GO:0022402 0.51 cell cycle process GO:0019538 0.51 protein metabolic process ==== CC ==== GO:0044424 1.00 intracellular part GO:0043226 0.89 organelle GO:0044446 0.87 intracellular organelle part GO:0044444 0.87 cytoplasmic part GO:0043227 0.83 membrane-bounded organelle GO:0043229 0.81 intracellular organelle GO:0032991 0.75 protein-containing complex GO:0043231 0.71 intracellular membrane-bounded organelle GO:0005737 0.52 cytoplasm GO:0044430 0.51 cytoskeletal part $$$$ A6NLU0-1 ubiquitin-protein transferase ==== MF ==== GO:0016740 0.83 transferase activity GO:0140096 0.82 catalytic activity, acting on a protein * GO:0004842 0.80 ubiquitin-protein transferase activity ==== BP ==== GO:0009987 0.96 cellular process GO:0050789 0.94 regulation of biological process GO:0050794 0.90 regulation of cellular process GO:0008152 0.80 metabolic process GO:0044237 0.78 cellular metabolic process GO:0048583 0.76 regulation of response to stimulus GO:0048519 0.75 negative regulation of biological process GO:0071704 0.72 organic substance metabolic process GO:0050896 0.71 response to stimulus GO:0044238 0.71 primary metabolic process GO:0023051 0.71 regulation of signaling GO:0016043 0.71 cellular component organization GO:0010646 0.71 regulation of cell communication GO:0019222 0.70 regulation of metabolic process GO:0009966 0.70 regulation of signal transduction GO:0048518 0.69 positive regulation of biological process GO:0006807 0.69 nitrogen compound metabolic process GO:0048523 0.68 negative regulation of cellular process GO:0043170 0.68 macromolecule metabolic process GO:0031323 0.67 regulation of cellular metabolic process GO:0080090 0.65 regulation of primary metabolic process GO:0060255 0.65 regulation of macromolecule metabolic process GO:0044260 0.65 cellular macromolecule metabolic process GO:0006950 0.65 response to stress GO:0051171 0.64 regulation of nitrogen compound metabolic process GO:1901564 0.63 organonitrogen compound metabolic process GO:0019538 0.61 protein metabolic process GO:0048522 0.59 positive regulation of cellular process GO:0043412 0.57 macromolecule modification GO:0006464 0.56 cellular protein modification process GO:0010468 0.55 regulation of gene expression GO:0002376 0.55 immune system process GO:0019219 0.54 regulation of nucleobase-containing compound metabolic process GO:2000112 0.53 regulation of cellular macromolecule biosynthetic process GO:0051252 0.53 regulation of RNA metabolic process GO:0048585 0.52 negative regulation of response to stimulus GO:0007166 0.52 cell surface receptor signaling pathway * GO:0016567 0.51 protein ubiquitination GO:0006355 0.51 regulation of transcription, DNA-templated GO:0009968 0.50 negative regulation of signal transduction ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.99 intracellular part GO:0043226 0.83 organelle GO:0043229 0.80 intracellular organelle GO:0044444 0.73 cytoplasmic part GO:0043227 0.71 membrane-bounded organelle GO:0043231 0.67 intracellular membrane-bounded organelle GO:0005737 0.62 cytoplasm GO:0044422 0.61 organelle part GO:0044446 0.60 intracellular organelle part GO:0032991 0.60 protein-containing complex GO:0005634 0.55 nucleus $$$$ A8MYV0-1 Protein serine/threonine kinase acting on microtubule ==== MF ==== * GO:0004674 0.69 protein serine/threonine kinase activity ==== BP ==== GO:0009987 0.99 cellular process GO:0032502 0.73 developmental process GO:0016043 0.71 cellular component organization GO:0019538 0.67 protein metabolic process GO:0065007 0.61 biological regulation GO:0048869 0.61 cellular developmental process GO:0050789 0.60 regulation of biological process GO:0050794 0.59 regulation of cellular process GO:0048856 0.59 anatomical structure development GO:0044237 0.54 cellular metabolic process GO:0022607 0.54 cellular component assembly GO:0006996 0.54 organelle organization * GO:0006468 0.53 protein phosphorylation GO:0050896 0.48 response to stimulus * GO:0007017 0.48 microtubule-based process * GO:0000226 0.47 microtubule cytoskeleton organization ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.96 intracellular part GO:0043226 0.74 organelle GO:0044444 0.57 cytoplasmic part GO:0043229 0.52 intracellular organelle * GO:0005856 0.47 cytoskeleton $$$$ O14894-1 ==== MF ==== ==== BP ==== GO:0050789 0.89 regulation of biological process GO:0050794 0.87 regulation of cellular process GO:0009987 0.86 cellular process GO:0032502 0.79 developmental process GO:0048856 0.76 anatomical structure development GO:0048519 0.67 negative regulation of biological process GO:0048523 0.66 negative regulation of cellular process GO:0048869 0.62 cellular developmental process GO:0019222 0.52 regulation of metabolic process GO:0060255 0.50 regulation of macromolecule metabolic process GO:0031323 0.50 regulation of cellular metabolic process ==== CC ==== GO:0016021 1.00 integral component of membrane GO:0044464 0.97 cell part GO:0044424 0.71 intracellular part GO:0044459 0.58 plasma membrane part GO:0005887 0.53 integral component of plasma membrane $$$$ O60829-1 hydratase (hydrolyase) to degrade phosphate containing molecules, such as RNA ==== MF ==== ==== BP ==== * GO:0006139 0.50 nucleobase-containing compound metabolic process ==== CC ==== * GO:0000015 1.00 phosphopyruvate hydratase complex GO:0005737 0.94 cytoplasm GO:0043226 0.65 organelle GO:1990904 0.64 ribonucleoprotein complex GO:0043229 0.58 intracellular organelle GO:0009986 0.56 cell surface GO:0043232 0.53 intracellular non-membrane-bounded organelle * GO:0043186 0.50 P granule $$$$ O60941-1 cytoskeleton-associated protein, possibly regulating muscle contraction ==== MF ==== * GO:0008092 0.79 cytoskeletal protein binding * GO:0005198 0.54 structural molecule activity * GO:0008307 0.49 structural constituent of muscle ==== BP ==== GO:0009987 0.97 cellular process GO:0065007 0.81 biological regulation GO:0050789 0.79 regulation of biological process GO:0016043 0.78 cellular component organization GO:0032502 0.74 developmental process GO:0048856 0.65 anatomical structure development GO:0050794 0.63 regulation of cellular process GO:0032501 0.62 multicellular organismal process GO:0006996 0.57 organelle organization * GO:0061061 0.55 muscle structure development GO:0048518 0.54 positive regulation of biological process * GO:0007010 0.49 cytoskeleton organization GO:0048513 0.47 animal organ development GO:0003008 0.47 system process * GO:0030029 0.46 actin filament-based process ==== CC ==== GO:0044424 1.00 intracellular part GO:0044425 0.92 membrane part GO:0044459 0.90 plasma membrane part GO:0032991 0.90 protein-containing complex GO:0098797 0.82 plasma membrane protein complex * GO:0016010 0.75 dystrophin-associated glycoprotein complex GO:0016020 0.69 membrane GO:0044422 0.68 organelle part GO:0044444 0.67 cytoplasmic part GO:0044446 0.63 intracellular organelle part GO:0043226 0.63 organelle GO:0005886 0.63 plasma membrane GO:0043229 0.62 intracellular organelle GO:0005737 0.53 cytoplasm GO:0043227 0.51 membrane-bounded organelle * GO:0042383 0.49 sarcolemma $$$$ O75363-1 (for CC: neuron part) ==== MF ==== GO:0042803 0.63 protein homodimerization activity ==== BP ==== GO:0009987 0.90 cellular process GO:0065007 0.81 biological regulation GO:0050789 0.74 regulation of biological process GO:0050794 0.72 regulation of cellular process GO:0008152 0.70 metabolic process ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.92 intracellular part GO:0043226 0.74 organelle GO:0043227 0.70 membrane-bounded organelle GO:0044444 0.58 cytoplasmic part GO:0043229 0.52 intracellular organelle GO:0044421 0.47 extracellular region part GO:0043231 0.46 intracellular membrane-bounded organelle GO:0044422 0.43 organelle part * GO:0097458 0.42 neuron part $$$$ O75677-1 ubiquitin-protein transferase activity ==== MF ==== GO:0140096 0.80 catalytic activity, acting on a protein GO:0016740 0.80 transferase activity * GO:0004842 0.78 ubiquitin-protein transferase activity ==== BP ==== GO:0009987 0.97 cellular process GO:0065007 0.93 biological regulation GO:0050789 0.92 regulation of biological process GO:0050794 0.88 regulation of cellular process GO:0008152 0.83 metabolic process GO:0044237 0.82 cellular metabolic process GO:0071704 0.75 organic substance metabolic process GO:0044238 0.74 primary metabolic process GO:0006807 0.72 nitrogen compound metabolic process GO:0048583 0.71 regulation of response to stimulus GO:0043170 0.70 macromolecule metabolic process GO:0048519 0.69 negative regulation of biological process GO:0048518 0.69 positive regulation of biological process GO:0019222 0.69 regulation of metabolic process GO:0050896 0.68 response to stimulus GO:0016043 0.68 cellular component organization GO:1901564 0.67 organonitrogen compound metabolic process GO:0031323 0.67 regulation of cellular metabolic process GO:0060255 0.66 regulation of macromolecule metabolic process GO:0044260 0.66 cellular macromolecule metabolic process GO:0080090 0.65 regulation of primary metabolic process GO:0051171 0.65 regulation of nitrogen compound metabolic process GO:0023051 0.65 regulation of signaling GO:0019538 0.65 protein metabolic process GO:0010646 0.65 regulation of cell communication GO:0009966 0.64 regulation of signal transduction GO:0002376 0.63 immune system process GO:0048523 0.61 negative regulation of cellular process GO:0006950 0.61 response to stress GO:0048522 0.59 positive regulation of cellular process GO:0044267 0.59 cellular protein metabolic process GO:0043412 0.59 macromolecule modification GO:0006464 0.58 cellular protein modification process GO:0010468 0.56 regulation of gene expression * GO:0016567 0.55 protein ubiquitination GO:0051252 0.54 regulation of RNA metabolic process GO:0031326 0.54 regulation of cellular biosynthetic process GO:0006355 0.53 regulation of transcription, DNA-templated GO:0006952 0.51 defense response ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.99 intracellular part GO:0043226 0.81 organelle GO:0043229 0.79 intracellular organelle GO:0044444 0.73 cytoplasmic part GO:0043227 0.68 membrane-bounded organelle GO:0032991 0.66 protein-containing complex GO:0043231 0.64 intracellular membrane-bounded organelle GO:0044422 0.63 organelle part GO:0044446 0.62 intracellular organelle part GO:0005737 0.59 cytoplasm GO:0005634 0.54 nucleus $$$$ O95801-1 heat shock protein binding ==== MF ==== GO:0140096 0.59 catalytic activity, acting on a protein * GO:0031072 0.48 heat shock protein binding ==== BP ==== GO:0009987 0.96 cellular process GO:0065007 0.68 biological regulation GO:0050789 0.65 regulation of biological process GO:0008152 0.64 metabolic process GO:0071704 0.63 organic substance metabolic process GO:0044237 0.63 cellular metabolic process GO:0044238 0.62 primary metabolic process GO:0050794 0.59 regulation of cellular process GO:0071840 0.56 cellular component organization or biogenesis GO:0016043 0.55 cellular component organization GO:0006807 0.52 nitrogen compound metabolic process GO:0043170 0.50 macromolecule metabolic process ==== CC ==== GO:0044424 1.00 intracellular part GO:0044444 0.93 cytoplasmic part GO:0005737 0.84 cytoplasm GO:0043226 0.79 organelle GO:0043229 0.77 intracellular organelle GO:0016020 0.74 membrane GO:0043227 0.73 membrane-bounded organelle GO:0044422 0.72 organelle part GO:0044446 0.71 intracellular organelle part GO:0043231 0.69 intracellular membrane-bounded organelle GO:0005829 0.66 cytosol GO:0032991 0.64 protein-containing complex GO:0005634 0.59 nucleus GO:0005886 0.56 plasma membrane GO:0044428 0.51 nuclear part $$$$ P0C870-1 histone demethylation ==== MF ==== GO:0016491 0.79 oxidoreductase activity GO:0016705 0.78 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0140096 0.77 catalytic activity, acting on a protein * GO:0016706 0.76 2-oxoglutarate-dependent dioxygenase activity GO:1901363 0.69 heterocyclic compound binding GO:0097159 0.69 organic cyclic compound binding * GO:0032452 0.63 histone demethylase activity GO:0043167 0.56 ion binding * GO:0003682 0.51 chromatin binding ==== BP ==== GO:0009987 1.00 cellular process GO:0008152 0.98 metabolic process GO:0071704 0.97 organic substance metabolic process GO:0044238 0.97 primary metabolic process GO:0044237 0.97 cellular metabolic process GO:1901564 0.96 organonitrogen compound metabolic process GO:0043412 0.95 macromolecule modification GO:0044260 0.84 cellular macromolecule metabolic process GO:0065007 0.78 biological regulation GO:0050789 0.77 regulation of biological process GO:0006464 0.76 cellular protein modification process GO:0050794 0.71 regulation of cellular process GO:0019222 0.64 regulation of metabolic process GO:0060255 0.63 regulation of macromolecule metabolic process GO:0080090 0.62 regulation of primary metabolic process GO:0051171 0.62 regulation of nitrogen compound metabolic process GO:0031323 0.62 regulation of cellular metabolic process GO:1901576 0.61 organic substance biosynthetic process GO:0016043 0.60 cellular component organization GO:0019219 0.59 regulation of nucleobase-containing compound metabolic process GO:0010468 0.59 regulation of gene expression GO:0051252 0.58 regulation of RNA metabolic process GO:1901360 0.56 organic cyclic compound metabolic process GO:0051179 0.56 localization GO:0046483 0.56 heterocycle metabolic process GO:0006725 0.56 cellular aromatic compound metabolic process GO:1901137 0.55 carbohydrate derivative biosynthetic process GO:0050896 0.55 response to stimulus GO:0006810 0.55 transport GO:0006139 0.55 nucleobase-containing compound metabolic process GO:0031590 0.54 wybutosine metabolic process GO:0009451 0.54 RNA modification GO:0008033 0.54 tRNA processing * GO:0016570 0.53 histone modification GO:0051716 0.52 cellular response to stimulus GO:0042221 0.50 response to chemical ==== CC ==== GO:0044424 1.00 intracellular part GO:0043229 0.89 intracellular organelle GO:0043227 0.88 membrane-bounded organelle GO:0043231 0.87 intracellular membrane-bounded organelle GO:0005634 0.77 nucleus GO:0044446 0.72 intracellular organelle part GO:0044444 0.65 cytoplasmic part GO:0032991 0.63 protein-containing complex GO:0042597 0.61 periplasmic space GO:1902494 0.60 catalytic complex GO:0044428 0.57 nuclear part $$$$ P0DPB3-1 DNA binding ==== MF ==== GO:1901363 0.61 heterocyclic compound binding GO:0097159 0.61 organic cyclic compound binding * GO:0003677 0.48 DNA binding ==== BP ==== GO:0009987 1.00 cellular process GO:0050789 0.97 regulation of biological process GO:0050794 0.93 regulation of cellular process GO:0048518 0.72 positive regulation of biological process GO:0048522 0.71 positive regulation of cellular process GO:0032502 0.64 developmental process GO:0016043 0.63 cellular component organization GO:0060255 0.62 regulation of macromolecule metabolic process GO:0051128 0.61 regulation of cellular component organization GO:0050793 0.59 regulation of developmental process GO:0009893 0.59 positive regulation of metabolic process GO:0010604 0.58 positive regulation of macromolecule metabolic process GO:0080090 0.57 regulation of primary metabolic process GO:0031323 0.57 regulation of cellular metabolic process GO:0051171 0.56 regulation of nitrogen compound metabolic process GO:0051173 0.53 positive regulation of nitrogen compound metabolic process GO:0031325 0.53 positive regulation of cellular metabolic process GO:0008152 0.53 metabolic process GO:0071704 0.52 organic substance metabolic process ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.96 intracellular part GO:0005737 0.74 cytoplasm GO:0044444 0.59 cytoplasmic part GO:0044422 0.58 organelle part GO:0016020 0.57 membrane GO:0043226 0.54 organelle GO:0043229 0.51 intracellular organelle GO:0030054 0.50 cell junction $$$$ P56378-1 ATPase or ATP synthase in mitochondrion ==== MF ==== GO:0016787 0.55 hydrolase activity * GO:0016887 0.49 ATPase activity ==== BP ==== GO:0009987 0.83 cellular process GO:0008152 0.72 metabolic process GO:0044237 0.71 cellular metabolic process GO:0071704 0.68 organic substance metabolic process GO:0044238 0.68 primary metabolic process GO:0006807 0.67 nitrogen compound metabolic process GO:0034641 0.60 cellular nitrogen compound metabolic process GO:1901360 0.59 organic cyclic compound metabolic process GO:0006139 0.58 nucleobase-containing compound metabolic process GO:1901564 0.55 organonitrogen compound metabolic process GO:0006810 0.54 transport ==== CC ==== GO:0005753 1.00 mitochondrial proton-transporting ATP synthase complex GO:0043229 0.80 intracellular organelle GO:0043227 0.78 membrane-bounded organelle GO:0043231 0.77 intracellular membrane-bounded organelle * GO:0005739 0.70 mitochondrion $$$$ P60827-1 signaling receptor binding ==== MF ==== GO:0005102 0.41 signaling receptor binding ==== BP ==== GO:0009987 0.93 cellular process GO:0065007 0.85 biological regulation GO:0050789 0.82 regulation of biological process GO:0048518 0.67 positive regulation of biological process GO:0032502 0.65 developmental process GO:0050896 0.62 response to stimulus GO:0050794 0.62 regulation of cellular process GO:0048583 0.62 regulation of response to stimulus GO:0016043 0.61 cellular component organization GO:0008152 0.61 metabolic process GO:0071704 0.56 organic substance metabolic process GO:0044238 0.54 primary metabolic process GO:0048584 0.53 positive regulation of response to stimulus ==== CC ==== GO:0016020 1.00 membrane GO:0044464 0.83 cell part GO:0044421 0.77 extracellular region part GO:0044424 0.65 intracellular part GO:0005615 0.58 extracellular space GO:0043226 0.53 organelle GO:0043227 0.52 membrane-bounded organelle GO:0005576 0.50 extracellular region $$$$ P84157-1 ==== MF ==== ==== BP ==== GO:0009987 0.88 cellular process GO:0065007 0.71 biological regulation GO:0050789 0.66 regulation of biological process GO:0008152 0.64 metabolic process GO:0050794 0.61 regulation of cellular process GO:0044237 0.61 cellular metabolic process GO:0071704 0.50 organic substance metabolic process ==== CC ==== GO:0044424 1.00 intracellular part GO:0044446 0.84 intracellular organelle part GO:0032991 0.82 protein-containing complex GO:0043226 0.77 organelle GO:0043229 0.75 intracellular organelle GO:0043227 0.73 membrane-bounded organelle GO:0043231 0.70 intracellular membrane-bounded organelle GO:0005634 0.61 nucleus GO:0044444 0.56 cytoplasmic part GO:0005737 0.53 cytoplasm GO:0044428 0.51 nuclear part $$$$ Q494U1-1 transmembrane transport of small molecules, such as nucleotide ==== MF ==== GO:0022857 0.93 transmembrane transporter activity GO:0015075 0.76 ion transmembrane transporter activity GO:0008509 0.75 anion transmembrane transporter activity GO:0008514 0.72 organic anion transmembrane transporter activity GO:0015605 0.63 organophosphate ester transmembrane transporter activity GO:0015318 0.63 inorganic molecular entity transmembrane transporter activity * GO:0008028 0.59 monocarboxylic acid transmembrane transporter activity ==== BP ==== GO:0006810 0.96 transport GO:0071702 0.93 organic substance transport GO:0055085 0.87 transmembrane transport GO:0009987 0.86 cellular process GO:0006811 0.78 ion transport GO:0034220 0.77 ion transmembrane transport GO:0015711 0.77 organic anion transport GO:0098656 0.76 anion transmembrane transport GO:0071705 0.71 nitrogen compound transport GO:1901264 0.68 carbohydrate derivative transport GO:0065007 0.62 biological regulation GO:0051641 0.57 cellular localization GO:0050789 0.57 regulation of biological process GO:0050794 0.56 regulation of cellular process GO:0046907 0.56 intracellular transport GO:0015931 0.55 nucleobase-containing compound transport GO:0007017 0.55 microtubule-based process GO:0006928 0.55 movement of cell or subcellular component GO:0046903 0.53 secretion GO:0030705 0.53 cytoskeleton-dependent intracellular transport * GO:0015780 0.53 nucleotide-sugar transmembrane transport ==== CC ==== GO:0044424 1.00 intracellular part GO:0044444 0.99 cytoplasmic part GO:0043226 0.97 organelle GO:0043231 0.96 intracellular membrane-bounded organelle GO:0044446 0.84 intracellular organelle part GO:0005737 0.71 cytoplasm GO:0032991 0.69 protein-containing complex * GO:0016020 0.62 membrane GO:0005794 0.58 Golgi apparatus GO:0005634 0.53 nucleus GO:0044428 0.52 nuclear part $$$$ Q5T0D9-1 phosphatidylinositol-4-phosphate phosphatase ==== MF ==== GO:0016787 0.93 hydrolase activity GO:0042803 0.92 protein homodimerization activity GO:0016791 0.92 phosphatase activity * GO:0034596 0.70 phosphatidylinositol phosphate 4-phosphatase activity * GO:0052833 0.68 inositol monophosphate 4-phosphatase activity ==== BP ==== GO:0065007 0.96 biological regulation GO:0050794 0.95 regulation of cellular process GO:0006810 0.94 transport GO:0051049 0.93 regulation of transport GO:2001135 0.92 regulation of endocytic recycling GO:0072583 0.92 clathrin-dependent endocytosis GO:0009987 0.91 cellular process GO:0008152 0.81 metabolic process GO:0071704 0.80 organic substance metabolic process GO:0044238 0.80 primary metabolic process GO:0044237 0.80 cellular metabolic process GO:0019222 0.76 regulation of metabolic process GO:0060255 0.75 regulation of macromolecule metabolic process GO:0050896 0.75 response to stimulus GO:0048523 0.75 negative regulation of cellular process GO:0048518 0.75 positive regulation of biological process GO:0080090 0.74 regulation of primary metabolic process GO:0051171 0.74 regulation of nitrogen compound metabolic process GO:0048522 0.74 positive regulation of cellular process GO:0044248 0.74 cellular catabolic process GO:0031323 0.74 regulation of cellular metabolic process GO:1901575 0.73 organic substance catabolic process GO:0048583 0.73 regulation of response to stimulus GO:0032501 0.73 multicellular organismal process GO:0031325 0.73 positive regulation of cellular metabolic process GO:0023051 0.73 regulation of signaling GO:0010646 0.73 regulation of cell communication GO:0010604 0.73 positive regulation of macromolecule metabolic process GO:0006950 0.73 response to stress GO:0051246 0.72 regulation of protein metabolic process GO:0051239 0.72 regulation of multicellular organismal process GO:0051172 0.72 negative regulation of nitrogen compound metabolic process GO:0050793 0.72 regulation of developmental process GO:0031324 0.72 negative regulation of cellular metabolic process GO:0023056 0.72 positive regulation of signaling GO:0019637 0.72 organophosphate metabolic process GO:0010605 0.72 negative regulation of macromolecule metabolic process GO:0009966 0.72 regulation of signal transduction GO:0006796 0.72 phosphate-containing compound metabolic process GO:2000145 0.71 regulation of cell motility GO:1902531 0.71 regulation of intracellular signal transduction GO:0080134 0.71 regulation of response to stress GO:0051241 0.71 negative regulation of multicellular organismal process GO:0051129 0.71 negative regulation of cellular component organization GO:0050767 0.71 regulation of neurogenesis GO:0045596 0.71 negative regulation of cell differentiation GO:0044255 0.71 cellular lipid metabolic process GO:0032101 0.71 regulation of response to external stimulus GO:0009968 0.71 negative regulation of signal transduction GO:0003008 0.71 system process GO:0001932 0.71 regulation of protein phosphorylation GO:0048681 0.70 negative regulation of axon regeneration * GO:0048015 0.70 phosphatidylinositol-mediated signaling * GO:0046856 0.70 phosphatidylinositol dephosphorylation GO:0042532 0.70 negative regulation of tyrosine phosphorylation of STAT protein * GO:0031161 0.70 phosphatidylinositol catabolic process GO:0014898 0.70 cardiac muscle hypertrophy in response to stress GO:0001921 0.70 positive regulation of receptor recycling ==== CC ==== GO:0044424 1.00 intracellular part GO:0005737 0.94 cytoplasm GO:0044444 0.63 cytoplasmic part GO:0043226 0.57 organelle GO:0043229 0.54 intracellular organelle GO:0043227 0.54 membrane-bounded organelle $$$$ Q5VTQ0-1 protein ubiquitination regulation ==== MF ==== * GO:0019899 0.52 enzyme binding ==== BP ==== GO:0009987 0.96 cellular process GO:0065007 0.81 biological regulation GO:0050789 0.79 regulation of biological process GO:0050794 0.76 regulation of cellular process GO:0008152 0.73 metabolic process GO:0071704 0.72 organic substance metabolic process GO:0044237 0.72 cellular metabolic process GO:0044238 0.71 primary metabolic process GO:0006807 0.69 nitrogen compound metabolic process GO:0043170 0.67 macromolecule metabolic process GO:1901564 0.65 organonitrogen compound metabolic process GO:0044260 0.64 cellular macromolecule metabolic process GO:0019538 0.62 protein metabolic process GO:0006464 0.60 cellular protein modification process GO:1901575 0.53 organic substance catabolic process GO:0044248 0.53 cellular catabolic process GO:0051128 0.52 regulation of cellular component organization * GO:0006508 0.52 proteolysis GO:0044265 0.51 cellular macromolecule catabolic process GO:0033043 0.50 regulation of organelle organization * GO:0016567 0.50 protein ubiquitination * GO:0051603 0.49 proteolysis involved in cellular protein catabolic process * GO:0043632 0.49 modification-dependent macromolecule catabolic process ==== CC ==== GO:0044424 1.00 intracellular part GO:0044444 0.91 cytoplasmic part GO:0032991 0.91 protein-containing complex GO:0043226 0.88 organelle GO:0043229 0.84 intracellular organelle GO:0043227 0.83 membrane-bounded organelle GO:0005737 0.82 cytoplasm GO:0043231 0.81 intracellular membrane-bounded organelle GO:0044422 0.78 organelle part GO:0044446 0.77 intracellular organelle part GO:0005634 0.74 nucleus GO:1902494 0.71 catalytic complex GO:0044428 0.68 nuclear part GO:0005829 0.64 cytosol GO:1990234 0.53 transferase complex $$$$ Q6AI39-1 sodium:potassium ion transporter ==== MF ==== GO:0097159 0.79 organic cyclic compound binding GO:1901363 0.78 heterocyclic compound binding GO:0043167 0.65 ion binding GO:0016787 0.63 hydrolase activity GO:0043168 0.61 anion binding GO:0097367 0.59 carbohydrate derivative binding GO:0036094 0.59 small molecule binding GO:0016462 0.59 pyrophosphatase activity GO:0017111 0.58 nucleoside-triphosphatase activity GO:0016887 0.57 ATPase activity GO:0042623 0.56 ATPase activity, coupled GO:0022857 0.56 transmembrane transporter activity GO:0046873 0.55 metal ion transmembrane transporter activity * GO:0005391 0.54 sodium:potassium-exchanging ATPase activity ==== BP ==== GO:0009987 0.95 cellular process GO:0065007 0.90 biological regulation GO:0050789 0.86 regulation of biological process GO:0050794 0.75 regulation of cellular process GO:0051179 0.67 localization GO:0006810 0.63 transport GO:0019222 0.58 regulation of metabolic process GO:0065008 0.57 regulation of biological quality GO:0060255 0.55 regulation of macromolecule metabolic process GO:0031323 0.55 regulation of cellular metabolic process GO:0006811 0.55 ion transport * GO:0010248 0.54 establishment or maintenance of transmembrane electrochemical gradient GO:0080090 0.53 regulation of primary metabolic process GO:0051171 0.52 regulation of nitrogen compound metabolic process GO:0010468 0.52 regulation of gene expression GO:0071704 0.50 organic substance metabolic process ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.96 intracellular part GO:0044425 0.85 membrane part GO:0016021 0.81 integral component of membrane GO:0043226 0.75 organelle GO:0016020 0.75 membrane GO:0044422 0.74 organelle part GO:0043229 0.73 intracellular organelle GO:0044446 0.72 intracellular organelle part GO:0043227 0.69 membrane-bounded organelle GO:0043231 0.65 intracellular membrane-bounded organelle GO:0032991 0.65 protein-containing complex GO:0044444 0.59 cytoplasmic part * GO:0005886 0.55 plasma membrane GO:0005634 0.55 nucleus GO:0044428 0.52 nuclear part $$$$ Q6ZNE9-2 regulation of protein folding ==== MF ==== * GO:0051082 0.44 unfolded protein binding * GO:0044183 0.44 protein binding involved in protein folding GO:0019899 0.42 enzyme binding GO:0051020 0.40 GTPase binding ==== BP ==== GO:0009987 0.96 cellular process GO:0065007 0.78 biological regulation GO:0071704 0.76 organic substance metabolic process GO:0044238 0.76 primary metabolic process GO:0044237 0.76 cellular metabolic process GO:0050794 0.75 regulation of cellular process GO:0006807 0.75 nitrogen compound metabolic process GO:0006139 0.74 nucleobase-containing compound metabolic process GO:0034654 0.71 nucleobase-containing compound biosynthetic process GO:0051179 0.69 localization GO:0051128 0.68 regulation of cellular component organization GO:0006810 0.68 transport GO:0055086 0.63 nucleobase-containing small molecule metabolic process GO:0051641 0.63 cellular localization GO:0006793 0.63 phosphorus metabolic process GO:0046907 0.57 intracellular transport GO:0031323 0.54 regulation of cellular metabolic process GO:1901135 0.53 carbohydrate derivative metabolic process * GO:0061077 0.51 chaperone-mediated protein folding * GO:0006458 0.51 'de novo' protein folding GO:0033043 0.49 regulation of organelle organization GO:0051640 0.46 organelle localization GO:0048518 0.46 positive regulation of biological process GO:0051656 0.45 establishment of organelle localization GO:0048522 0.45 positive regulation of cellular process GO:1901564 0.43 organonitrogen compound metabolic process GO:0051130 0.43 positive regulation of cellular component organization GO:1901137 0.41 carbohydrate derivative biosynthetic process ==== CC ==== GO:0044446 1.00 intracellular organelle part GO:0043231 1.00 intracellular membrane-bounded organelle GO:0044444 0.98 cytoplasmic part GO:0005737 0.76 cytoplasm GO:0005829 0.72 cytosol GO:0032991 0.68 protein-containing complex GO:0005634 0.66 nucleus GO:0016020 0.58 membrane GO:0031982 0.54 vesicle GO:0031410 0.48 cytoplasmic vesicle GO:0005768 0.46 endosome GO:0044428 0.45 nuclear part $$$$ Q6ZW76-1 transferase acting on a protein ==== MF ==== * GO:0140096 0.52 catalytic activity, acting on a protein * GO:0016740 0.51 transferase activity ==== BP ==== GO:0009987 0.95 cellular process GO:0065007 0.86 biological regulation GO:0050789 0.83 regulation of biological process GO:0050794 0.81 regulation of cellular process GO:0044237 0.58 cellular metabolic process GO:0071704 0.57 organic substance metabolic process GO:0044238 0.56 primary metabolic process GO:0006807 0.54 nitrogen compound metabolic process GO:0016043 0.52 cellular component organization GO:0019222 0.51 regulation of metabolic process ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.98 intracellular part GO:0043226 0.86 organelle GO:0043229 0.85 intracellular organelle GO:0043227 0.82 membrane-bounded organelle GO:0043231 0.75 intracellular membrane-bounded organelle GO:0044444 0.74 cytoplasmic part GO:0005737 0.70 cytoplasm GO:0016020 0.69 membrane GO:0005634 0.64 nucleus GO:0044425 0.63 membrane part GO:0044422 0.62 organelle part GO:0044446 0.57 intracellular organelle part GO:0016021 0.57 integral component of membrane GO:0032991 0.56 protein-containing complex $$$$ Q70Z53-1 cytoskelton organization and cytoskelton based transport ==== MF ==== GO:0016787 0.58 hydrolase activity * GO:0045503 0.48 dynein light chain binding ==== BP ==== GO:0009987 0.95 cellular process GO:0016043 0.78 cellular component organization GO:0032502 0.77 developmental process GO:0006996 0.76 organelle organization GO:0009653 0.75 anatomical structure morphogenesis GO:0048598 0.74 embryonic morphogenesis GO:0008152 0.66 metabolic process GO:0071704 0.60 organic substance metabolic process GO:0065007 0.60 biological regulation GO:0044238 0.60 primary metabolic process GO:0044237 0.59 cellular metabolic process GO:0006807 0.59 nitrogen compound metabolic process GO:0050789 0.58 regulation of biological process GO:0050794 0.57 regulation of cellular process GO:0043170 0.56 macromolecule metabolic process GO:0022607 0.53 cellular component assembly GO:0034641 0.52 cellular nitrogen compound metabolic process GO:0120036 0.51 plasma membrane bounded cell projection organization GO:0070925 0.51 organelle assembly GO:0006139 0.51 nucleobase-containing compound metabolic process GO:0090304 0.50 nucleic acid metabolic process * GO:0060271 0.50 cilium assembly * GO:0048704 0.50 embryonic skeletal system morphogenesis ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.99 intracellular part GO:0044425 0.80 membrane part GO:0043226 0.79 organelle GO:0016021 0.78 integral component of membrane GO:0043227 0.77 membrane-bounded organelle GO:0016020 0.76 membrane GO:0044422 0.75 organelle part GO:0044446 0.74 intracellular organelle part GO:0032991 0.70 protein-containing complex GO:0044444 0.67 cytoplasmic part GO:0043229 0.58 intracellular organelle GO:1902494 0.56 catalytic complex GO:0043231 0.54 intracellular membrane-bounded organelle GO:0031982 0.52 vesicle GO:0120038 0.51 plasma membrane bounded cell projection part * GO:0044430 0.50 cytoskeletal part GO:0044421 0.50 extracellular region part GO:0120025 0.49 plasma membrane bounded cell projection GO:0005615 0.49 extracellular space * GO:0000922 0.49 spindle pole GO:0097546 0.48 ciliary base GO:0070062 0.48 extracellular exosome * GO:0031021 0.48 interphase microtubule organizing center GO:0005929 0.48 cilium * GO:0005868 0.48 cytoplasmic dynein complex * GO:0005813 0.48 centrosome * GO:0000242 0.48 pericentriolar material $$$$ Q7Z5A7-1 regulation of microglial cell activation ==== MF ==== ==== BP ==== GO:0050789 1.00 regulation of biological process GO:0050794 0.85 regulation of cellular process GO:0009987 0.84 cellular process GO:0048522 0.75 positive regulation of cellular process GO:0048583 0.73 regulation of response to stimulus GO:0048523 0.72 negative regulation of cellular process GO:0048584 0.71 positive regulation of response to stimulus GO:0048585 0.67 negative regulation of response to stimulus * GO:0031347 0.67 regulation of defense response * GO:0002682 0.67 regulation of immune system process * GO:1903980 0.66 positive regulation of microglial cell activation * GO:1903979 0.66 negative regulation of microglial cell activation ==== CC ==== GO:0044464 0.95 cell part GO:0044424 0.85 intracellular part GO:0044421 0.74 extracellular region part GO:0005615 0.73 extracellular space GO:0043226 0.67 organelle GO:0043229 0.66 intracellular organelle GO:0044444 0.62 cytoplasmic part GO:0043227 0.62 membrane-bounded organelle GO:0043231 0.60 intracellular membrane-bounded organelle GO:0005783 0.50 endoplasmic reticulum $$$$ Q8IUW5-1 regulation of apoptosis through TNF ==== MF ==== * GO:0005031 0.40 tumor necrosis factor-activated receptor activity ==== BP ==== GO:0050789 1.00 regulation of biological process GO:0009987 0.70 cellular process GO:0050794 0.65 regulation of cellular process GO:0048518 0.64 positive regulation of biological process * GO:0097190 0.51 apoptotic signaling pathway * GO:0042981 0.51 regulation of apoptotic process * GO:0042127 0.51 regulation of cell proliferation GO:0032496 0.51 response to lipopolysaccharide GO:0007275 0.51 multicellular organism development * GO:0006955 0.51 immune response * GO:0006954 0.51 inflammatory response ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.80 intracellular part GO:0043229 0.76 intracellular organelle $$$$ Q8IUY3-1 binding of GTPase from Ras superfamily ==== MF ==== GO:0098772 0.64 molecular function regulator * GO:0017016 0.63 Ras GTPase binding * GO:0005096 0.62 GTPase activator activity * GO:0017137 0.61 Rab GTPase binding ==== BP ==== GO:0065007 0.85 biological regulation GO:0051179 0.84 localization GO:0051641 0.83 cellular localization GO:0050794 0.82 regulation of cellular process GO:0071702 0.81 organic substance transport GO:0046907 0.81 intracellular transport GO:0050790 0.79 regulation of catalytic activity GO:0043085 0.78 positive regulation of catalytic activity GO:0051336 0.77 regulation of hydrolase activity GO:0051345 0.76 positive regulation of hydrolase activity GO:0032879 0.76 regulation of localization GO:0051128 0.74 regulation of cellular component organization * GO:0043087 0.74 regulation of GTPase activity * GO:0090630 0.73 activation of GTPase activity GO:0031338 0.73 regulation of vesicle fusion GO:0006886 0.73 intracellular protein transport ==== CC ==== GO:0044464 0.96 cell part GO:0012505 0.56 endomembrane system GO:0005622 0.56 intracellular $$$$ Q8N957-1 nucleotide excision repair ==== MF ==== ==== BP ==== GO:0009987 0.97 cellular process GO:0065007 0.85 biological regulation GO:0050789 0.83 regulation of biological process GO:0050794 0.81 regulation of cellular process GO:0032502 0.77 developmental process GO:0016043 0.73 cellular component organization GO:0008152 0.61 metabolic process GO:0044237 0.59 cellular metabolic process GO:0071704 0.58 organic substance metabolic process GO:0044238 0.56 primary metabolic process GO:0006807 0.56 nitrogen compound metabolic process GO:0048518 0.55 positive regulation of biological process GO:0050896 0.54 response to stimulus GO:0043170 0.53 macromolecule metabolic process GO:0044260 0.50 cellular macromolecule metabolic process ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.98 intracellular part GO:0032991 0.86 protein-containing complex GO:0043226 0.76 organelle GO:0044422 0.75 organelle part GO:0043229 0.73 intracellular organelle GO:0044446 0.70 intracellular organelle part GO:0044444 0.68 cytoplasmic part GO:0043227 0.64 membrane-bounded organelle GO:0043231 0.59 intracellular membrane-bounded organelle GO:0005737 0.56 cytoplasm GO:0005634 0.50 nucleus * GO:1902494 0.48 catalytic complex * GO:0009380 0.44 excinuclease repair complex $$$$ Q8NDM7-1 ==== MF ==== ==== BP ==== GO:0009987 0.98 cellular process GO:0065007 0.70 biological regulation GO:0050789 0.68 regulation of biological process GO:0050794 0.66 regulation of cellular process GO:0071840 0.61 cellular component organization or biogenesis GO:0016043 0.60 cellular component organization GO:0044237 0.50 cellular metabolic process ==== CC ==== GO:0044464 0.99 cell part GO:0044424 0.98 intracellular part GO:0044446 0.81 intracellular organelle part GO:0043226 0.74 organelle GO:0043229 0.68 intracellular organelle GO:0044444 0.65 cytoplasmic part GO:0043227 0.63 membrane-bounded organelle GO:0032991 0.63 protein-containing complex GO:0043231 0.54 intracellular membrane-bounded organelle $$$$ Q8TDG2-1 regulation of chromosome organization either though histone acetylation or binding of cytoskelton used in chromsome segregation ==== MF ==== GO:0005198 0.90 structural molecule activity GO:1901363 0.89 heterocyclic compound binding GO:0097159 0.89 organic cyclic compound binding GO:0005200 0.89 structural constituent of cytoskeleton GO:0043167 0.85 ion binding GO:0035639 0.84 purine ribonucleoside triphosphate binding GO:0032555 0.84 purine ribonucleotide binding GO:0016740 0.66 transferase activity * GO:0004402 0.61 histone acetyltransferase activity * GO:0008092 0.59 cytoskeletal protein binding ==== BP ==== GO:0065007 0.96 biological regulation GO:0050789 0.95 regulation of biological process GO:0009987 0.90 cellular process GO:0060255 0.89 regulation of macromolecule metabolic process GO:0048518 0.89 positive regulation of biological process GO:0010468 0.88 regulation of gene expression GO:0009893 0.85 positive regulation of metabolic process GO:0016043 0.78 cellular component organization GO:0010604 0.78 positive regulation of macromolecule metabolic process GO:0010628 0.77 positive regulation of gene expression GO:0032501 0.76 multicellular organismal process GO:0050794 0.74 regulation of cellular process GO:0090131 0.71 mesenchyme migration GO:0032502 0.71 developmental process GO:0044237 0.70 cellular metabolic process GO:0071704 0.69 organic substance metabolic process GO:0044238 0.69 primary metabolic process GO:0006996 0.69 organelle organization GO:0050896 0.68 response to stimulus GO:0006807 0.68 nitrogen compound metabolic process GO:1901564 0.67 organonitrogen compound metabolic process GO:0044260 0.67 cellular macromolecule metabolic process GO:0022607 0.66 cellular component assembly GO:0051716 0.65 cellular response to stimulus GO:0048869 0.65 cellular developmental process GO:0044267 0.65 cellular protein metabolic process GO:0043412 0.65 macromolecule modification GO:0042221 0.64 response to chemical GO:0006950 0.64 response to stress GO:0006464 0.64 cellular protein modification process * GO:0006325 0.64 chromatin organization GO:1901360 0.63 organic cyclic compound metabolic process GO:0034641 0.63 cellular nitrogen compound metabolic process GO:0022402 0.63 cell cycle process GO:0070887 0.62 cellular response to chemical stimulus GO:0033554 0.62 cellular response to stress GO:0022414 0.62 reproductive process GO:0006139 0.62 nucleobase-containing compound metabolic process GO:0090304 0.61 nucleic acid metabolic process GO:0048646 0.61 anatomical structure formation involved in morphogenesis * GO:0018193 0.61 peptidyl-amino acid modification * GO:0016570 0.61 histone modification GO:0003006 0.61 developmental process involved in reproduction GO:1903046 0.60 meiotic cell cycle process GO:0032506 0.60 cytokinetic process * GO:0016573 0.60 histone acetylation GO:0010927 0.60 cellular component assembly involved in morphogenesis * GO:0006281 0.60 DNA repair GO:0034599 0.59 cellular response to oxidative stress GO:0030476 0.59 ascospore wall assembly GO:0001300 0.59 chronological cell aging * GO:0000916 0.59 actomyosin contractile ring contraction GO:0000011 0.59 vacuole inheritance GO:0080090 0.57 regulation of primary metabolic process GO:0051171 0.57 regulation of nitrogen compound metabolic process GO:0031323 0.57 regulation of cellular metabolic process GO:0031326 0.54 regulation of cellular biosynthetic process GO:0019219 0.54 regulation of nucleobase-containing compound metabolic process GO:0010556 0.54 regulation of macromolecule biosynthetic process GO:0048522 0.53 positive regulation of cellular process GO:0048519 0.53 negative regulation of biological process * GO:0006355 0.53 regulation of transcription, DNA-templated GO:0051179 0.51 localization GO:0048523 0.51 negative regulation of cellular process ==== CC ==== GO:0044424 1.00 intracellular part GO:0043226 0.94 organelle GO:0043229 0.93 intracellular organelle GO:0044446 0.88 intracellular organelle part GO:0032991 0.79 protein-containing complex GO:0044444 0.77 cytoplasmic part GO:0043227 0.74 membrane-bounded organelle GO:0005737 0.73 cytoplasm GO:0043231 0.71 intracellular membrane-bounded organelle GO:0043232 0.70 intracellular non-membrane-bounded organelle * GO:0005856 0.66 cytoskeleton GO:0005634 0.64 nucleus * GO:0044430 0.60 cytoskeletal part GO:0042995 0.54 cell projection GO:0016020 0.53 membrane $$$$ Q8WTR8-1 anatomical structure morphogenesis ==== MF ==== ==== BP ==== GO:0009987 0.98 cellular process GO:0065007 0.88 biological regulation GO:0050789 0.86 regulation of biological process GO:0032502 0.86 developmental process GO:0050794 0.84 regulation of cellular process GO:0016043 0.71 cellular component organization GO:0006928 0.68 movement of cell or subcellular component * GO:0048856 0.66 anatomical structure development * GO:0009653 0.63 anatomical structure morphogenesis GO:0048869 0.62 cellular developmental process GO:0048518 0.60 positive regulation of biological process GO:0048522 0.55 positive regulation of cellular process GO:0051239 0.52 regulation of multicellular organismal process GO:0050793 0.52 regulation of developmental process GO:0051128 0.51 regulation of cellular component organization GO:0048519 0.51 negative regulation of biological process GO:2000026 0.50 regulation of multicellular organismal development GO:0048583 0.48 regulation of response to stimulus * GO:0007411 0.48 axon guidance GO:0045595 0.47 regulation of cell differentiation GO:0048523 0.46 negative regulation of cellular process GO:0022603 0.46 regulation of anatomical structure morphogenesis GO:0120035 0.45 regulation of plasma membrane bounded cell projection organization * GO:0051960 0.45 regulation of nervous system development * GO:0050767 0.44 regulation of neurogenesis * GO:0045664 0.43 regulation of neuron differentiation GO:0030030 0.43 cell projection organization * GO:0010975 0.42 regulation of neuron projection development * GO:0010769 0.41 regulation of cell morphogenesis involved in differentiation ==== CC ==== GO:0019031 1.00 viral envelope GO:0044464 0.94 cell part GO:0044424 0.70 intracellular part GO:0044421 0.69 extracellular region part GO:0044425 0.58 membrane part GO:0062023 0.53 collagen-containing extracellular matrix GO:0044459 0.52 plasma membrane part $$$$ Q8WXF5-1 structure component of eye lens ==== MF ==== * GO:0005212 0.95 structural constituent of eye lens ==== BP ==== GO:0032502 0.91 developmental process GO:0032501 0.86 multicellular organismal process GO:0003008 0.85 system process GO:0007601 0.84 visual perception GO:0009987 0.81 cellular process GO:0048856 0.77 anatomical structure development GO:0009653 0.63 anatomical structure morphogenesis * GO:0048513 0.59 animal organ development GO:0002009 0.59 morphogenesis of an epithelium * GO:0001654 0.58 eye development GO:0065007 0.49 biological regulation * GO:0002088 0.49 lens development in camera-type eye ==== CC ==== GO:0005737 1.00 cytoplasm GO:0005634 1.00 nucleus $$$$ Q96A25-1 lysosomal transport and lysosome organization ==== MF ==== GO:0016787 0.44 hydrolase activity ==== BP ==== GO:0048813 1.00 dendrite morphogenesis * GO:0032418 1.00 lysosome localization GO:0006996 0.93 organelle organization GO:0006810 0.93 transport * GO:0007041 0.92 lysosomal transport * GO:0007040 0.92 lysosome organization GO:0065007 0.64 biological regulation GO:0050789 0.59 regulation of biological process GO:0050794 0.57 regulation of cellular process ==== CC ==== GO:0044424 1.00 intracellular part GO:0044444 0.98 cytoplasmic part GO:0016020 0.94 membrane GO:0044446 0.93 intracellular organelle part GO:0098588 0.87 bounding membrane of organelle GO:0044437 0.87 vacuolar part GO:0043226 0.87 organelle GO:0043229 0.86 intracellular organelle GO:0005774 0.86 vacuolar membrane GO:0043227 0.85 membrane-bounded organelle * GO:0005765 0.85 lysosomal membrane GO:0043231 0.83 intracellular membrane-bounded organelle GO:0005773 0.55 vacuole GO:0031982 0.50 vesicle $$$$ Q96D15-1 catalytic activity, acting on a protein ==== MF ==== * GO:0140096 0.41 catalytic activity, acting on a protein ==== BP ==== GO:0009987 0.95 cellular process GO:0065007 0.83 biological regulation GO:0050789 0.78 regulation of biological process GO:0050794 0.75 regulation of cellular process GO:0071704 0.66 organic substance metabolic process GO:0044237 0.65 cellular metabolic process GO:0044238 0.64 primary metabolic process GO:0006807 0.63 nitrogen compound metabolic process GO:0043170 0.61 macromolecule metabolic process GO:0044260 0.56 cellular macromolecule metabolic process GO:1901564 0.54 organonitrogen compound metabolic process GO:0019538 0.52 protein metabolic process GO:0043412 0.51 macromolecule modification ==== CC ==== GO:0044424 1.00 intracellular part GO:0043226 0.94 organelle GO:0043229 0.93 intracellular organelle GO:0043227 0.92 membrane-bounded organelle GO:0044444 0.90 cytoplasmic part GO:0043231 0.90 intracellular membrane-bounded organelle GO:0044446 0.82 intracellular organelle part GO:0016020 0.80 membrane GO:0005886 0.72 plasma membrane GO:0005737 0.69 cytoplasm GO:0044425 0.61 membrane part GO:0005634 0.61 nucleus GO:0044459 0.54 plasma membrane part GO:0005783 0.53 endoplasmic reticulum $$$$ Q96F63-1 splicesome protein ==== MF ==== ==== BP ==== GO:0009987 0.83 cellular process GO:0008152 0.54 metabolic process GO:0071704 0.53 organic substance metabolic process GO:0044238 0.53 primary metabolic process GO:0044237 0.53 cellular metabolic process GO:0006807 0.50 nitrogen compound metabolic process ==== CC ==== * GO:0005686 1.00 U2 snRNP $$$$ Q96II8-1 transferase acting on a protein ==== MF ==== * GO:0140096 0.45 catalytic activity, acting on a protein * GO:0016740 0.45 transferase activity ==== BP ==== GO:0009987 0.97 cellular process GO:0065007 0.93 biological regulation GO:0050789 0.92 regulation of biological process GO:0050794 0.90 regulation of cellular process ==== CC ==== GO:0044464 1.00 cell part GO:0016021 1.00 integral component of membrane GO:0044424 0.94 intracellular part GO:0016020 0.79 membrane GO:0005886 0.63 plasma membrane GO:0005737 0.62 cytoplasm GO:0043226 0.55 organelle GO:0044444 0.51 cytoplasmic part GO:0043229 0.51 intracellular organelle $$$$ Q96J88-1 cytoskeleton binding ==== MF ==== * GO:0008092 0.43 cytoskeletal protein binding ==== BP ==== GO:0009987 0.95 cellular process GO:0065007 0.83 biological regulation GO:0050789 0.80 regulation of biological process GO:0050794 0.77 regulation of cellular process GO:0016043 0.73 cellular component organization GO:0006996 0.63 organelle organization GO:0048518 0.61 positive regulation of biological process GO:0048522 0.58 positive regulation of cellular process * GO:0007010 0.54 cytoskeleton organization GO:0022607 0.53 cellular component assembly * GO:0032185 0.47 septin cytoskeleton organization * GO:0007017 0.47 microtubule-based process ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.98 intracellular part GO:0044444 0.84 cytoplasmic part GO:0043226 0.82 organelle GO:0043229 0.80 intracellular organelle GO:0044422 0.77 organelle part GO:0044446 0.75 intracellular organelle part GO:0043227 0.72 membrane-bounded organelle GO:0005737 0.66 cytoplasm GO:0043231 0.63 intracellular membrane-bounded organelle GO:0016020 0.62 membrane GO:0032991 0.59 protein-containing complex * GO:0044430 0.55 cytoskeletal part GO:0043232 0.54 intracellular non-membrane-bounded organelle $$$$ Q96KV7-1 regulation of transcription by nucleic acid binding ==== MF ==== GO:1901363 0.59 heterocyclic compound binding GO:0097159 0.59 organic cyclic compound binding * GO:0140110 0.46 transcription regulator activity GO:0003677 0.41 DNA binding ==== BP ==== GO:0009987 0.92 cellular process GO:0065007 0.84 biological regulation GO:0050789 0.82 regulation of biological process GO:0050794 0.80 regulation of cellular process GO:0019222 0.66 regulation of metabolic process GO:0060255 0.64 regulation of macromolecule metabolic process GO:0080090 0.63 regulation of primary metabolic process GO:0031323 0.63 regulation of cellular metabolic process GO:0051171 0.62 regulation of nitrogen compound metabolic process * GO:0010468 0.60 regulation of gene expression GO:0019219 0.59 regulation of nucleobase-containing compound metabolic process GO:2000112 0.58 regulation of cellular macromolecule biosynthetic process * GO:0051252 0.58 regulation of RNA metabolic process GO:0071840 0.57 cellular component organization or biogenesis * GO:0006355 0.57 regulation of transcription, DNA-templated GO:0044237 0.56 cellular metabolic process GO:0016043 0.54 cellular component organization GO:0071704 0.53 organic substance metabolic process GO:0044238 0.53 primary metabolic process GO:0006807 0.53 nitrogen compound metabolic process GO:0043170 0.52 macromolecule metabolic process GO:0048519 0.46 negative regulation of biological process GO:0048518 0.46 positive regulation of biological process GO:0048523 0.44 negative regulation of cellular process GO:0048522 0.44 positive regulation of cellular process * GO:0006357 0.43 regulation of transcription by RNA polymerase II ==== CC ==== GO:0044424 1.00 intracellular part GO:0043226 0.87 organelle GO:0043229 0.86 intracellular organelle GO:0043227 0.80 membrane-bounded organelle GO:0043231 0.78 intracellular membrane-bounded organelle GO:0044446 0.77 intracellular organelle part GO:0032991 0.75 protein-containing complex * GO:0005634 0.75 nucleus * GO:0044428 0.56 nuclear part $$$$ Q96M27-1 protein kinase A regulation ==== MF ==== * GO:0034237 0.65 protein kinase A regulatory subunit binding ==== BP ==== GO:0065007 0.94 biological regulation GO:0050789 0.92 regulation of biological process GO:0050794 0.91 regulation of cellular process GO:0060255 0.82 regulation of macromolecule metabolic process GO:0031323 0.81 regulation of cellular metabolic process GO:0080090 0.80 regulation of primary metabolic process GO:0051171 0.80 regulation of nitrogen compound metabolic process GO:0048518 0.79 positive regulation of biological process GO:0048522 0.77 positive regulation of cellular process GO:0009987 0.77 cellular process GO:0065008 0.74 regulation of biological quality GO:0032501 0.74 multicellular organismal process GO:0010604 0.73 positive regulation of macromolecule metabolic process GO:0051173 0.72 positive regulation of nitrogen compound metabolic process GO:0031325 0.72 positive regulation of cellular metabolic process GO:0065009 0.71 regulation of molecular function GO:0051246 0.71 regulation of protein metabolic process GO:0032268 0.70 regulation of cellular protein metabolic process GO:0050790 0.69 regulation of catalytic activity GO:0031399 0.69 regulation of protein modification process GO:0051247 0.68 positive regulation of protein metabolic process GO:0044093 0.68 positive regulation of molecular function GO:0019220 0.68 regulation of phosphate metabolic process GO:0045859 0.67 regulation of protein kinase activity GO:0042592 0.67 homeostatic process * GO:0001934 0.67 positive regulation of protein phosphorylation GO:0043085 0.66 positive regulation of catalytic activity GO:0007389 0.66 pattern specification process * GO:0034199 0.65 activation of protein kinase A activity GO:0010669 0.65 epithelial structure maintenance GO:0001757 0.65 somite specification ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.99 intracellular part GO:0043226 0.92 organelle GO:0043229 0.90 intracellular organelle GO:0044444 0.89 cytoplasmic part GO:0043227 0.88 membrane-bounded organelle GO:0043231 0.86 intracellular membrane-bounded organelle GO:0005737 0.72 cytoplasm GO:0005794 0.59 Golgi apparatus GO:0044422 0.54 organelle part $$$$ Q96S16-1 histone demethylation ==== MF ==== GO:0016491 0.88 oxidoreductase activity GO:0140096 0.87 catalytic activity, acting on a protein GO:0051213 0.87 dioxygenase activity * GO:0016705 0.87 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen * GO:0016706 0.79 2-oxoglutarate-dependent dioxygenase activity * GO:0032452 0.75 histone demethylase activity GO:0043167 0.66 ion binding GO:1901363 0.65 heterocyclic compound binding GO:0097159 0.65 organic cyclic compound binding GO:0043169 0.64 cation binding * GO:0003682 0.50 chromatin binding ==== BP ==== GO:0009987 0.99 cellular process GO:0071704 0.97 organic substance metabolic process GO:0044238 0.97 primary metabolic process GO:0044237 0.97 cellular metabolic process GO:1901564 0.96 organonitrogen compound metabolic process GO:0043170 0.96 macromolecule metabolic process GO:0043412 0.95 macromolecule modification GO:0044260 0.92 cellular macromolecule metabolic process GO:0019538 0.89 protein metabolic process GO:0006464 0.88 cellular protein modification process GO:0050789 0.84 regulation of biological process GO:0050794 0.77 regulation of cellular process GO:0019222 0.76 regulation of metabolic process GO:0080090 0.75 regulation of primary metabolic process GO:0060255 0.75 regulation of macromolecule metabolic process GO:0031323 0.75 regulation of cellular metabolic process GO:0051171 0.74 regulation of nitrogen compound metabolic process GO:0019219 0.71 regulation of nucleobase-containing compound metabolic process GO:0010468 0.71 regulation of gene expression GO:0051252 0.70 regulation of RNA metabolic process GO:0016043 0.67 cellular component organization * GO:0018193 0.63 peptidyl-amino acid modification * GO:0006325 0.63 chromatin organization * GO:0016570 0.61 histone modification * GO:0016577 0.52 histone demethylation GO:0031326 0.50 regulation of cellular biosynthetic process ==== CC ==== GO:0044424 1.00 intracellular part GO:0043226 0.95 organelle GO:0043229 0.93 intracellular organelle GO:0043227 0.93 membrane-bounded organelle GO:0043231 0.90 intracellular membrane-bounded organelle GO:0044446 0.86 intracellular organelle part * GO:0005634 0.86 nucleus * GO:0044428 0.79 nuclear part GO:0044444 0.65 cytoplasmic part * GO:0005654 0.61 nucleoplasm GO:0032991 0.58 protein-containing complex $$$$ Q9BZD6-1 serine-type endopeptidase ==== MF ==== GO:0140096 0.91 catalytic activity, acting on a protein GO:0016787 0.90 hydrolase activity * GO:0070011 0.89 peptidase activity, acting on L-amino acid peptides * GO:0004175 0.84 endopeptidase activity * GO:0008236 0.79 serine-type peptidase activity * GO:0004252 0.74 serine-type endopeptidase activity GO:0043167 0.53 ion binding ==== BP ==== GO:0065007 0.96 biological regulation GO:0065008 0.90 regulation of biological quality GO:0050789 0.87 regulation of biological process GO:0050878 0.82 regulation of body fluid levels GO:0009987 0.78 cellular process GO:0048583 0.77 regulation of response to stimulus GO:0051239 0.71 regulation of multicellular organismal process GO:0032101 0.64 regulation of response to external stimulus GO:0048519 0.63 negative regulation of biological process GO:0008152 0.63 metabolic process GO:0071704 0.62 organic substance metabolic process GO:0050794 0.60 regulation of cellular process GO:0044238 0.60 primary metabolic process GO:0080134 0.59 regulation of response to stress GO:0050818 0.59 regulation of coagulation GO:0048518 0.58 positive regulation of biological process GO:0006807 0.57 nitrogen compound metabolic process GO:0043170 0.56 macromolecule metabolic process * GO:0030193 0.56 regulation of blood coagulation GO:1901564 0.55 organonitrogen compound metabolic process GO:0051241 0.54 negative regulation of multicellular organismal process GO:0048585 0.54 negative regulation of response to stimulus GO:0032501 0.52 multicellular organismal process GO:0019538 0.51 protein metabolic process ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.93 intracellular part GO:0005737 0.74 cytoplasm GO:0043226 0.71 organelle GO:0043227 0.69 membrane-bounded organelle GO:0044421 0.67 extracellular region part GO:0005615 0.65 extracellular space GO:0043229 0.64 intracellular organelle GO:0043231 0.61 intracellular membrane-bounded organelle $$$$ Q9BZH6-1 ==== MF ==== GO:0097159 0.60 organic cyclic compound binding GO:1901363 0.59 heterocyclic compound binding ==== BP ==== GO:0009987 0.97 cellular process GO:0065007 0.85 biological regulation GO:0050789 0.82 regulation of biological process GO:0050794 0.80 regulation of cellular process GO:0044237 0.75 cellular metabolic process GO:0071704 0.73 organic substance metabolic process GO:0044238 0.73 primary metabolic process GO:0071840 0.72 cellular component organization or biogenesis GO:0006807 0.72 nitrogen compound metabolic process GO:0043170 0.71 macromolecule metabolic process GO:0016043 0.69 cellular component organization GO:0048518 0.63 positive regulation of biological process GO:0019222 0.62 regulation of metabolic process GO:0060255 0.61 regulation of macromolecule metabolic process GO:0031323 0.61 regulation of cellular metabolic process GO:0080090 0.60 regulation of primary metabolic process GO:0051171 0.60 regulation of nitrogen compound metabolic process GO:0048522 0.59 positive regulation of cellular process GO:0050896 0.58 response to stimulus GO:1901360 0.56 organic cyclic compound metabolic process GO:0044260 0.56 cellular macromolecule metabolic process GO:0034641 0.56 cellular nitrogen compound metabolic process GO:0032502 0.56 developmental process GO:0006725 0.56 cellular aromatic compound metabolic process GO:0046483 0.55 heterocycle metabolic process GO:0022607 0.55 cellular component assembly GO:0090304 0.54 nucleic acid metabolic process GO:0019219 0.53 regulation of nucleobase-containing compound metabolic process GO:0048583 0.51 regulation of response to stimulus GO:0009893 0.51 positive regulation of metabolic process GO:0051173 0.50 positive regulation of nitrogen compound metabolic process GO:0043933 0.50 protein-containing complex subunit organization GO:0031325 0.50 positive regulation of cellular metabolic process GO:0010604 0.50 positive regulation of macromolecule metabolic process ==== CC ==== GO:0044424 1.00 intracellular part GO:0043229 0.97 intracellular organelle GO:0032991 0.96 protein-containing complex GO:0044446 0.95 intracellular organelle part GO:0043227 0.89 membrane-bounded organelle GO:0043231 0.88 intracellular membrane-bounded organelle GO:0044444 0.87 cytoplasmic part GO:0005737 0.82 cytoplasm GO:0044428 0.72 nuclear part GO:0005634 0.71 nucleus GO:1902494 0.57 catalytic complex GO:0044425 0.55 membrane part GO:0005829 0.50 cytosol $$$$ Q9C0D6-1 binding of cytoskeleton ==== MF ==== * GO:0008092 0.70 cytoskeletal protein binding GO:0019899 0.48 enzyme binding GO:0016787 0.41 hydrolase activity ==== BP ==== GO:0009987 0.95 cellular process GO:0065007 0.82 biological regulation GO:0050789 0.80 regulation of biological process GO:0050794 0.75 regulation of cellular process GO:0016043 0.69 cellular component organization GO:0032502 0.54 developmental process GO:0048518 0.48 positive regulation of biological process GO:0051128 0.46 regulation of cellular component organization GO:0065008 0.44 regulation of biological quality GO:0006996 0.43 organelle organization GO:0022607 0.42 cellular component assembly GO:0048522 0.41 positive regulation of cellular process GO:0006928 0.40 movement of cell or subcellular component ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.99 intracellular part GO:0032991 0.87 protein-containing complex GO:0044444 0.85 cytoplasmic part GO:0043226 0.84 organelle GO:0044422 0.83 organelle part GO:0043229 0.83 intracellular organelle GO:0044446 0.82 intracellular organelle part GO:0043227 0.72 membrane-bounded organelle GO:0005737 0.69 cytoplasm GO:0043231 0.68 intracellular membrane-bounded organelle GO:0016020 0.64 membrane GO:0005634 0.53 nucleus GO:0005829 0.48 cytosol * GO:0044430 0.47 cytoskeletal part GO:0043232 0.44 intracellular non-membrane-bounded organelle GO:0044428 0.43 nuclear part GO:0044425 0.40 membrane part $$$$ Q9GZU8-1 hydrolase, probably hydrolase of protein ==== MF ==== GO:0043167 0.54 ion binding * GO:0016787 0.53 hydrolase activity * GO:0140096 0.48 catalytic activity, acting on a protein ==== BP ==== GO:0009987 0.88 cellular process GO:0065007 0.82 biological regulation GO:0050789 0.80 regulation of biological process GO:0050794 0.79 regulation of cellular process GO:0008152 0.70 metabolic process GO:0071704 0.67 organic substance metabolic process GO:0044238 0.67 primary metabolic process GO:0006807 0.65 nitrogen compound metabolic process GO:0043170 0.61 macromolecule metabolic process GO:1901564 0.55 organonitrogen compound metabolic process GO:0071840 0.53 cellular component organization or biogenesis GO:0048519 0.52 negative regulation of biological process GO:0016043 0.52 cellular component organization GO:0048523 0.51 negative regulation of cellular process GO:0044237 0.51 cellular metabolic process * GO:0019538 0.50 protein metabolic process ==== CC ==== GO:0044464 0.99 cell part GO:0044424 0.98 intracellular part GO:0044422 0.73 organelle part GO:0005576 0.69 extracellular region GO:0044446 0.68 intracellular organelle part GO:0043226 0.67 organelle GO:0043229 0.66 intracellular organelle GO:0044444 0.58 cytoplasmic part GO:0043227 0.58 membrane-bounded organelle GO:0043231 0.55 intracellular membrane-bounded organelle GO:0016020 0.54 membrane GO:0044425 0.51 membrane part $$$$ Q9H5V9-1 mRNA splicing ==== MF ==== ==== BP ==== * GO:0000398 1.00 mRNA splicing, via spliceosome ==== CC ==== GO:0044424 1.00 intracellular part * GO:1902494 0.74 catalytic complex * GO:0071013 0.70 catalytic step 2 spliceosome $$$$ Q9H9L7-1 by binding to RNA polymerase, regulate expression of genes such as cytokines ==== MF ==== * GO:0019899 0.77 enzyme binding ==== BP ==== * GO:0045944 1.00 positive regulation of transcription by RNA polymerase II GO:0050896 0.91 response to stimulus GO:0009605 0.90 response to external stimulus GO:0043207 0.89 response to external biotic stimulus GO:0009987 0.85 cellular process GO:1901700 0.71 response to oxygen-containing compound GO:0051239 0.71 regulation of multicellular organismal process GO:0010033 0.71 response to organic substance GO:0051240 0.70 positive regulation of multicellular organismal process GO:0033993 0.69 response to lipid GO:0032496 0.68 response to lipopolysaccharide * GO:0001819 0.68 positive regulation of cytokine production * GO:0032755 0.67 positive regulation of interleukin-6 production GO:0032502 0.65 developmental process GO:0048856 0.61 anatomical structure development ==== CC ==== * GO:0005634 1.00 nucleus GO:0032991 0.90 protein-containing complex GO:0044422 0.76 organelle part GO:0044446 0.75 intracellular organelle part GO:0017053 0.65 transcriptional repressor complex GO:0044428 0.58 nuclear part GO:0044444 0.52 cytoplasmic part $$$$ Q9NVP4-1 ==== MF ==== ==== BP ==== GO:0009987 0.93 cellular process GO:0065007 0.85 biological regulation GO:0050789 0.80 regulation of biological process GO:0050794 0.79 regulation of cellular process GO:0032502 0.51 developmental process GO:0016043 0.50 cellular component organization ==== CC ==== GO:0044464 1.00 cell part GO:0044424 0.98 intracellular part GO:0043226 0.79 organelle GO:0043229 0.78 intracellular organelle GO:0005737 0.72 cytoplasm GO:0043227 0.69 membrane-bounded organelle GO:0044444 0.68 cytoplasmic part GO:0043231 0.63 intracellular membrane-bounded organelle GO:0044422 0.56 organelle part GO:0044446 0.52 intracellular organelle part $$$$