6kyf A 3.07 BS01 NAD A 1 H7 G8 S9 E11 I13 I16 R17 S19 G20 G24 L25 F26 H37 Q96 D115 H117 T120 H12 G13 S14 E16 I18 I21 R22 S24 G25 G29 L30 F31 H42 Q101 D120 H122 T125 GPLGSMSMELFHGSYEEISEIRDSGVFGGLFGAHEKETALSHGETLHRIISPLPLTDYALNYEIESAWEVALDVAGGDENVAEAIMAKACESDSNDGWELQRLRGVLAVRLGYTSVEMEDEHGTTWLCLPGCTVEKI 6kyu A 1.50 BS01 III C 1 Y7 D9 S24 D34 T43 Y58 R61 Q62 E64 I65 S66 A69 I72 F73 D76 T79 L80 W93 L95 Y97 T140 K143 W144 E147 D150 R153 W154 Y157 T161 Y169 Y7 D9 S24 D34 T43 Y58 R61 Q62 E64 I65 S66 A69 I72 F73 D76 T79 L80 W93 L95 Y97 T140 K143 W144 E147 D150 R153 W154 Y157 T161 Y169 EPHSLRYFDTGVSDPSPGVPRFVSVGYVDGHLIDHYDSETQRTEPRADWFAANTDQQYWDRQTEISRGAEQIFRLDLETLRERYNQSRGSHTWQLMYGCDLLEDGSTRGFRQYGYEGRDFVAFDKDTLTFTAADAGAQITKRKWEQEGTDAERWKFYLENTCIEGLRKYVSYGKDVLERRERPEVQVSGMEADKILTLSCRAHGFYPRPISISWLKDGMVQEQETKRGSTVPNSDGTYHIWATIDVLPGERDKYQCRVEHASLPQPGLFSW 6kyv B 3.00 BS01 NUC A 1 N298 Q299 I300 S325 G326 T347 Q349 N353 K379 Q380 H381 Q498 I499 Q500 Q507 E510 Q511 K518 R546 K635 T636 R637 T662 G663 R664 N668 Q678 T697 S698 N720 K750 H830 F853 K858 G874 I875 V886 K888 S906 W908 N57 Q58 I59 S84 G85 T106 Q108 N112 K138 Q139 H140 Q257 I258 Q259 Q266 E269 Q270 K277 R305 K391 T392 R393 T418 G419 R420 N424 Q434 T453 S454 N476 K506 H584 F607 K612 G628 I629 V640 K642 S660 W662 3.6.4.13 KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRADEIEQDLTQRFEEKLQELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPF 6kyv D 3.00 BS01 NUC C 1 N298 Q299 I300 S325 G326 T347 Q349 I350 K379 Q380 H381 Q498 I499 Q500 E510 Q511 V514 K518 R546 K635 T636 R637 T662 G663 R664 N668 Q678 T697 S698 N720 K750 H830 F853 K858 I875 V886 K888 S906 W908 N57 Q58 I59 S84 G85 T106 Q108 I109 K138 Q139 H140 Q257 I258 Q259 E269 Q270 V273 K277 R305 K391 T392 R393 T418 G419 R420 N424 Q434 T453 S454 N476 K506 H584 F607 K612 I629 V640 K642 S660 W662 3.6.4.13 KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRADEIEQDLTQRFEEKLQELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPF 6kyv F 3.00 BS01 NUC E 1 N298 Q299 I300 S325 G326 T347 Q349 I350 N353 K379 Q380 H381 Q498 E510 K518 R546 K635 T636 R637 T662 G663 R664 T667 N668 Q678 T697 S698 N720 K750 H830 F853 K858 G874 I875 V886 K888 S906 K907 W908 N57 Q58 I59 S84 G85 T106 Q108 I109 N112 K138 Q139 H140 Q257 E269 K277 R305 K391 T392 R393 T418 G419 R420 T423 N424 Q434 T453 S454 N476 K506 H584 F607 K612 G628 I629 V640 K642 S660 K661 W662 3.6.4.13 KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRADEIEQDLTQRFEEKLQELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPF 6kyv H 3.00 BS01 NUC G 1 N298 I300 S325 G326 T347 Q349 I350 K379 Q380 H381 P382 Q498 I499 E510 Q511 R546 K635 T636 R637 T662 G663 R664 T667 N668 Q678 T697 S698 N720 K750 H830 F853 K858 I875 V886 K888 S906 W908 N57 I59 S84 G85 T106 Q108 I109 K138 Q139 H140 P141 Q257 I258 E269 Q270 R305 K391 T392 R393 T418 G419 R420 T423 N424 Q434 T453 S454 N476 K506 H584 F607 K612 I629 V640 K642 S660 W662 3.6.4.13 KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRADEIEQDLTQRFEEKLQELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPF 6kyv J 3.00 BS01 NUC I 1 N298 Q299 I300 S325 G326 T347 Q349 I350 K379 Q380 H381 P382 Q498 I499 E510 Q511 V514 K518 R546 K635 T636 R637 T662 G663 R664 N668 Q678 T697 S698 N720 K750 C829 H830 F853 K858 I875 V886 K888 S906 K907 W908 N57 Q58 I59 S84 G85 T106 Q108 I109 K138 Q139 H140 P141 Q257 I258 E269 Q270 V273 K277 R305 K391 T392 R393 T418 G419 R420 N424 Q434 T453 S454 N476 K506 C583 H584 F607 K612 I629 V640 K642 S660 K661 W662 3.6.4.13 KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRADEIEQDLTQRFEEKLQELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPF 6kyv L 3.00 BS01 NUC K 1 N298 Q299 I300 S325 G326 T347 Q349 I350 Q380 H381 Q498 I499 Q511 K518 R546 K635 R637 T662 G663 R664 T667 N668 Q678 T697 S698 N720 K750 C829 H830 F853 K858 G874 I875 V886 K888 S906 K907 W908 N57 Q58 I59 S84 G85 T106 Q108 I109 Q139 H140 Q257 I258 Q270 K277 R305 K391 R393 T418 G419 R420 T423 N424 Q434 T453 S454 N476 K506 C583 H584 F607 K612 G628 I629 V640 K642 S660 K661 W662 3.6.4.13 KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRADEIEQDLTQRFEEKLQELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPF 6kzk A 2.79 BS01 BEM D 1 G122 R135 Y151 Y153 Y161 G235 G104 R117 Y133 Y135 Y143 G217 AIPSSLSINWNNYATGAYSSGNAASDFGNAGGWNQSRSYISDGTLRVTLLKNALSGAGGLISNIDVSDGTEYELDYDVRFHSQFDWSRGGAVGFGFSIGEGNTGGDPGWDGNGGTLRMAWYQTDAGRVFFQPYIYHKDQPGQYGDTFGKSYPSSGSITKGTTYHVHVYIKSNTGSNRDGRAQIIINGTTVLDTAIRWTTNDAQRLIKNMTFHTFRGGSQTYWQSPVDSYIYYDNLVLRKIR 6kzk A 2.79 BS02 BEM D 2 Y151 Y161 G235 S236 Q237 Y133 Y143 G217 S218 Q219 AIPSSLSINWNNYATGAYSSGNAASDFGNAGGWNQSRSYISDGTLRVTLLKNALSGAGGLISNIDVSDGTEYELDYDVRFHSQFDWSRGGAVGFGFSIGEGNTGGDPGWDGNGGTLRMAWYQTDAGRVFFQPYIYHKDQPGQYGDTFGKSYPSSGSITKGTTYHVHVYIKSNTGSNRDGRAQIIINGTTVLDTAIRWTTNDAQRLIKNMTFHTFRGGSQTYWQSPVDSYIYYDNLVLRKIR 6kzk A 2.79 BS04 CA A 1 N27 N29 G61 D251 N252 N9 N11 G43 D233 N234 AIPSSLSINWNNYATGAYSSGNAASDFGNAGGWNQSRSYISDGTLRVTLLKNALSGAGGLISNIDVSDGTEYELDYDVRFHSQFDWSRGGAVGFGFSIGEGNTGGDPGWDGNGGTLRMAWYQTDAGRVFFQPYIYHKDQPGQYGDTFGKSYPSSGSITKGTTYHVHVYIKSNTGSNRDGRAQIIINGTTVLDTAIRWTTNDAQRLIKNMTFHTFRGGSQTYWQSPVDSYIYYDNLVLRKIR 6kzk B 2.79 BS01 BEM E 1 T121 G122 R135 Y151 Y153 Y161 F232 G235 T103 G104 R117 Y133 Y135 Y143 F214 G217 AIPSSLSINWNNYATGAYSSGNAASDFGNAGGWNQSRSYISDGTLRVTLLKNALSGAGGLISNIDVSDGTEYELDYDVRFHSQFDWSRGGAVGFGFSIGEGNTGGDPGWDGNGGTLRMAWYQTDAGRVFFQPYIYHKDQPGQYGDTFGKSYPSSGSITKGTTYHVHVYIKSNTGSNRDGRAQIIINGTTVLDTAIRWTTNDAQRLIKNMTFHTFRGGSQTYWQSPVDSYIYYDNLVLRKIR 6kzk B 2.79 BS02 BEM E 2 Y151 Y161 G235 S236 Q237 W240 Y133 Y143 G217 S218 Q219 W222 AIPSSLSINWNNYATGAYSSGNAASDFGNAGGWNQSRSYISDGTLRVTLLKNALSGAGGLISNIDVSDGTEYELDYDVRFHSQFDWSRGGAVGFGFSIGEGNTGGDPGWDGNGGTLRMAWYQTDAGRVFFQPYIYHKDQPGQYGDTFGKSYPSSGSITKGTTYHVHVYIKSNTGSNRDGRAQIIINGTTVLDTAIRWTTNDAQRLIKNMTFHTFRGGSQTYWQSPVDSYIYYDNLVLRKIR 6kzk C 2.79 BS01 BEM F 1 S73 G122 R135 Y151 F232 G234 G235 S236 S55 G104 R117 Y133 F214 G216 G217 S218 AIPSSLSINWNNYATGAYSSGNAASDFGNAGGWNQSRSYISDGTLRVTLLKNALSGAGGLISNIDVSDGTEYELDYDVRFHSQFDWSRGGAVGFGFSIGEGNTGGDPGWDGNGGTLRMAWYQTDAGRVFFQPYIYHKDQPGQYGDTFGKSYPSSGSITKGTTYHVHVYIKSNTGSNRDGRAQIIINGTTVLDTAIRWTTNDAQRLIKNMTFHTFRGGSQTYWQSPVDSYIYYDNLVLRKIR 6kzk C 2.79 BS03 BEM F 3 R106 Y139 Q237 Y239 W240 R88 Y121 Q219 Y221 W222 AIPSSLSINWNNYATGAYSSGNAASDFGNAGGWNQSRSYISDGTLRVTLLKNALSGAGGLISNIDVSDGTEYELDYDVRFHSQFDWSRGGAVGFGFSIGEGNTGGDPGWDGNGGTLRMAWYQTDAGRVFFQPYIYHKDQPGQYGDTFGKSYPSSGSITKGTTYHVHVYIKSNTGSNRDGRAQIIINGTTVLDTAIRWTTNDAQRLIKNMTFHTFRGGSQTYWQSPVDSYIYYDNLVLRKIR 6kzs A 1.60 BS01 HEM A 1 R69 I91 N92 R103 I155 T242 T246 T247 Q250 R296 Y319 T346 F347 H352 C354 G356 L359 A360 R60 I82 N83 R94 I146 T233 T237 T238 Q241 R287 Y310 T337 F338 H343 C345 G347 L350 A351 1.14.-.- TVRNCPFDYAHELEFDPQLRQLLTEEPVSRIRMAYGEGEAWLVTRYEDVRTVTTDRRFSRSAVLGRDFPRMTPEPIVQAESINLMDPPASSRLRGLVAKSFTPRRVEQMRGGTQRVVDRLLDEMEEEGSPADFVARVSAPLPLITICEALDIPEADRPWLRAHAMTMMNVGAAGKQDAVRAKAELRGYFQELTADRRRSPGEDLISTLATARDGDELLDDDELAVMAMVLLITGQDTTTYQLGNIAYTLLTRPDLLRSLRAEPQRLPRTLEELLRHIPFRKGVGIPRIALEDVELSGVLIKAGDVVHVSYLTANRDSAKFDRPDELDPDRPTIPHMTFGWGAHHCLGAPLATMELEVAFSTLLTRFPALRLDVPPEDVSWNTTSIWRYPLALPVTW 6kzs A 1.60 BS02 IMD A 1 T242 D245 T246 T233 D236 T237 1.14.-.- TVRNCPFDYAHELEFDPQLRQLLTEEPVSRIRMAYGEGEAWLVTRYEDVRTVTTDRRFSRSAVLGRDFPRMTPEPIVQAESINLMDPPASSRLRGLVAKSFTPRRVEQMRGGTQRVVDRLLDEMEEEGSPADFVARVSAPLPLITICEALDIPEADRPWLRAHAMTMMNVGAAGKQDAVRAKAELRGYFQELTADRRRSPGEDLISTLATARDGDELLDDDELAVMAMVLLITGQDTTTYQLGNIAYTLLTRPDLLRSLRAEPQRLPRTLEELLRHIPFRKGVGIPRIALEDVELSGVLIKAGDVVHVSYLTANRDSAKFDRPDELDPDRPTIPHMTFGWGAHHCLGAPLATMELEVAFSTLLTRFPALRLDVPPEDVSWNTTSIWRYPLALPVTW 6kzt A 3.50 BS01 HEM A 1 R69 I91 R103 L239 T242 G243 T246 T247 Q250 Y319 T346 F347 G348 H352 C354 L355 G356 A360 R60 I82 R94 L230 T233 G234 T237 T238 Q241 Y310 T337 F338 G339 H343 C345 L346 G347 A351 1.14.-.- TVRNCPFDYAHELEFDPQLRQLLTEEPVSRIRMAYGEGEAWLVTRYEDVRTVTTDRRFSRSAVLGRDFPRMTPEPIVQAESINLMDPPASSRLRGLVAKSFTPRRVEQMRGGTQRVVDRLLDEMEEEGSPADFVARVSAPLPLITICEALDIPEADRPWLRAHAMTMMNVGAAGKQDAVRAKAELRGYFQELTADRRRSPGEDLISTLATARDGDELLDDDELAVMAMVLLITGQDTTTYQLGNIAYTLLTRPDLLRSLRAEPQRLPRTLEELLRHIPFRKGVGIPRIALEDVELSGVLIKAGDVVHVSYLTANRDSAKFDRPDELDPDRPTIPHMTFGWGAHHCLGAPLATMELEVAFSTLLTRFPALRLDVPPEDVSWNTTSIWRYPLALPVTW 6l0p A 1.79 BS01 E1U A 1 T152 S153 S154 N155 F156 T203 Q224 Y225 S259 G261 T262 S263 G264 H265 G295 I296 S341 P368 D369 T151 S152 S153 N154 F155 T202 Q223 Y224 S258 G260 T261 S262 G263 H264 G294 I295 S340 P367 D368 4.2.1.22,2.5.1.47,2.5.1.65 ALADISGYLDVLDSVRGFSYLENAREVLRSGEARCLGNPRSEPEYVKALYVIGASRIPVGDGCSHTLEELGVFDISVPGEMVFPSPLDFFERGKPTPLVRSRLQLPNGVRVWLKLEWYNPFSLSVADRPAVEIISRLSRRVEKGSLVADATSSNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAPSTVHLLPRVMKDSKNEGFVHVNQYYNDANFEAHMRGTAREIFVQSRRGGLALRGVAGSLGTSGHMSAAAFYLQSVDPSIRAVLVQPAQGDSIPGIARVETGMLWINMLDISYTLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAKKAAEGDLEPGDYVVVVPDTGFKYLSLVQNALE 6l0p B 1.79 BS01 E1U B 1 T152 S153 N155 F156 T203 Q224 Y225 G261 T262 S263 G264 H265 P294 G295 I296 S341 P368 D369 Y374 T151 S152 N154 F155 T202 Q223 Y224 G260 T261 S262 G263 H264 P293 G294 I295 S340 P367 D368 Y373 4.2.1.22,2.5.1.47,2.5.1.65 ALADISGYLDVLDSVRGFSYLENAREVLRSGEARCLGNPRSEPEYVKALYVIGASRIPVGDGCSHTLEELGVFDISVPGEMVFPSPLDFFERGKPTPLVRSRLQLPNGVRVWLKLEWYNPFSLSVADRPAVEIISRLSRRVEKGSLVADATSSNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAPSTVHLLPRVMKDSKNEGFVHVNQYYNDANFEAHMRGTAREIFVQSRRGGLALRGVAGSLGTSGHMSAAAFYLQSVDPSIRAVLVQPAQGDSIPGIARVETGMLWINMLDISYTLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAKKAAEGDLEPGDYVVVVPDTGFKYLSLVQNALE 6l0q A 1.58 BS01 E1U A 1 T152 S153 N155 F156 T203 Q224 Y225 S259 L260 G261 T262 S263 G264 H265 G295 I296 R297 S341 P368 Y374 T151 S152 N154 F155 T202 Q223 Y224 S258 L259 G260 T261 S262 G263 H264 G294 I295 R296 S340 P367 Y373 4.2.1.22,2.5.1.47,2.5.1.65 ALADISGYLDVLDSVRGFSYLENAREVLRSGEARCLGNPRSEPEYVKALYVIGASRIPVGDGCSHTLEELGVFDISVPGEMVFPSPLDFFERGKPTPLVRSRLQLPNGVRVWLKLEWYNPFSLSVADRPAVEIISRLSRRVEKGSLVADATSSNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAPSTVHLLPRVMKDSKNEGFVHVNQYYNDANFEAHMRGTAREIFVQSRRGGLALRGVAGSLGTSGHMSAAAFYLQSVDPSIRAVLVQPAQGDSIPGIRRVETGMLWINMLDISYTLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAKKAAEGDLEPGDYVVVVPDTGFKYLSLVQNALE 6l0q B 1.58 BS01 E1U B 1 T152 S153 N155 F156 T203 Q224 Y225 S259 G261 T262 S263 H265 G295 I296 S341 P368 D369 T151 S152 N154 F155 T202 Q223 Y224 S258 G260 T261 S262 H264 G294 I295 S340 P367 D368 4.2.1.22,2.5.1.47,2.5.1.65 ALADISGYLDVLDSVRGFSYLENAREVLRSGEARCLGNPRSEPEYVKALYVIGASRIPVGDGCSHTLEELGVFDISVPGEMVFPSPLDFFERGKPTPLVRSRLQLPNGVRVWLKLEWYNPFSLSVADRPAVEIISRLSRRVEKGSLVADATSSNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAPSTVHLLPRVMKDSKNEGFVHVNQYYNDANFEAHMRGTAREIFVQSRRGGLALRGVAGSLGTSGHMSAAAFYLQSVDPSIRAVLVQPAQGDSIPGIRRVETGMLWINMLDISYTLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAKKAAEGDLEPGDYVVVVPDTGFKYLSLVQNALE 6l0q D 1.58 BS01 E1U D 1 T152 S153 N155 F156 T203 Q224 Y225 S259 L260 G261 T262 S263 G264 H265 G295 I296 S341 P368 D369 Y374 T151 S152 N154 F155 T202 Q223 Y224 S258 L259 G260 T261 S262 G263 H264 G294 I295 S340 P367 D368 Y373 4.2.1.22,2.5.1.47,2.5.1.65 ALADISGYLDVLDSVRGFSYLENAREVLRSGEARCLGNPRSEPEYVKALYVIGASRIPVGDGCSHTLEELGVFDISVPGEMVFPSPLDFFERGKPTPLVRSRLQLPNGVRVWLKLEWYNPFSLSVADRPAVEIISRLSRRVEKGSLVADATSSNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAPSTVHLLPRVMKDSKNEGFVHVNQYYNDANFEAHMRGTAREIFVQSRRGGLALRGVAGSLGTSGHMSAAAFYLQSVDPSIRAVLVQPAQGDSIPGIRRVETGMLWINMLDISYTLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAKKAAEGDLEPGDYVVVVPDTGFKYLSLVQNALE 6l0s D 1.96 BS01 E1O D 1 T152 S153 N155 F156 Q224 Y225 S259 L260 G261 T262 S263 G264 H265 G295 I296 S341 P368 D369 T151 S152 N154 F155 Q223 Y224 S258 L259 G260 T261 S262 G263 H264 G294 I295 S340 P367 D368 4.2.1.22,2.5.1.47,2.5.1.65 ALADISGYLDVLDSVRGFSYLENAREVLRSGEARCLGNPRSEPEYVKALYVIGASRIPVGDGCSHTLEELGVFDISVPGEMVFPSPLDFFERGKPTPLVRSRLQLPNGVRVWLKLEWYNPFSLSVADRPAVEIISRLSRRVEKGSLVADATSSNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAPSTVHLLPRVMKDSKNEGFVHVNQYYNDANFEAHMRGTAREIFVQSRRGGLALRGVAGSLGTSGHMSAAAFYLQSVDPSIRAVLVQPAQGDSIPGIARVETGMLWINMLDISYTLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAKKAAEGDLEPGDYVVVVPDTGFKYLSLVQNALE 6l1f B 1.90 BS01 III A 1 D23 Y24 L25 Y29 F47 R49 W50 Y54 D21 Y22 L23 Y27 F45 R47 W48 Y52 32885980 HMPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSHRYDEWIYWDSNRLRPLE 6l1p B 1.23 BS01 E3X B 1 D23 L25 Y29 F47 W50 Y54 D22 L24 Y28 F46 W49 Y53 32885980 SHMPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSHRYDEWIYWDSNRLRPLER 6l1p A 1.23 BS01 E3X A 1 D23 Y24 L25 Y29 F47 W50 Y54 D21 Y22 L23 Y27 F45 W48 Y52 32885980 HMPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSHRYDEWIYWDSNRLRPLER 6l69 A 1.50 BS01 HEM A 1 L51 M87 L88 H95 R99 L231 M232 A235 G236 T239 T240 V285 R288 Y311 S340 F341 G342 H346 C348 P349 G350 L353 S354 L49 M85 L86 H93 R97 L229 M230 A233 G234 T237 T238 V283 R286 Y309 S338 F339 G340 H344 C346 P347 G348 L351 S352 31767148 TRIALDPFVSDLEAESAALRAAGPLAAVELPGGVPVWAVTHHAEAKKLLTDPRLVKDINVWGAWQRGEIAPDWPLIGLANPGRSMLTVDGADHRRMRTLVAQALTPRRVEQMRERITKLTEELLDRLTGEVVDLKADFAYPLPMYVVADLMGIDEARLPRLGELFEKFFSTQTPPAEVIATLTELAGIMAETVAAKRAAPGDDLTSALILASEDGDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPEQRALVLSGEADWSSVVEETLRYSTPTSHVLIRFATEDVPVGDKVLPAGDALIVSYGALGRDEAAHGPTAGEFDITRSTENRHISFGHGPHVCPGAALSRLEAGVALPALYARFPKLDLAVPAAELRNKPVVTQNDLFELPVRLG 6m4d A 4.40 BS01 NUC I 1 R63 K64 L65 P66 R69 R83 K115 R5 K6 L7 P8 R11 R25 K57 ELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 6m4d A 4.40 BS02 NUC J 1 R72 R83 F84 Q85 S86 R116 V117 T118 R14 R25 F26 Q27 S28 R58 V59 T60 ELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 6m4d B 4.40 BS01 NUC I 1 R35 R45 I46 S47 G48 L49 R78 K79 T80 R13 R23 I24 S25 G26 L27 R56 K57 T58 RDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6m4d B 4.40 BS02 NUC J 1 T30 K31 P32 R36 R45 K77 T8 K9 P10 R14 R23 K55 RDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6m4d C 4.40 BS01 NUC I 1 K37 R45 V46 G47 A48 R80 K22 R30 V31 G32 A33 R65 AVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAG 6m4d C 4.40 BS02 NUC J 1 A16 V17 S18 R19 G30 R31 R34 A1 V2 S3 R4 G15 R16 R19 AVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAG 6m4d E 4.40 BS01 NUC I 1 R63 R72 R83 F84 Q85 S86 R116 V117 T118 R5 R14 R25 F26 Q27 S28 R58 V59 T60 ELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 6m4d E 4.40 BS02 NUC J 1 K64 L65 R69 R83 K115 K6 L7 R11 R25 K57 ELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 6m4d F 4.40 BS01 NUC I 1 T30 K31 P32 A33 R36 R45 K77 T8 K9 P10 A11 R14 R23 K55 RDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6m4d G 4.40 BS02 NUC J 1 K37 R45 V46 G47 R80 K22 R30 V31 G32 R65 AVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAG 6m4g A 2.80 BS01 NUC I 1 K64 L65 R69 R83 K5 L6 R10 R24 LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGE 6m4g A 2.80 BS02 NUC J 1 R63 R72 R83 F84 Q85 S86 R116 V117 T118 M120 R4 R13 R24 F25 Q26 S27 R57 V58 T59 M61 LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGE 6m4g D 2.80 BS01 NUC J 1 S87 T88 S52 T53 SYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTS 6m4g E 2.80 BS01 NUC I 1 R63 R72 R83 F84 S86 R116 V117 T118 M120 R4 R13 R24 F25 S27 R57 V58 T59 M61 LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGE 6m4g E 2.80 BS02 NUC J 1 L65 R69 R83 L6 R10 R24 LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGE 6m4g C 2.80 BS01 NUC I 1 R39 R46 L47 S48 R49 R20 R27 L28 S29 R30 SRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVIEYLTAKVLELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQV 6m4g C 2.80 BS02 NUC J 1 R21 R24 S32 R2 R5 S13 SRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVIEYLTAKVLELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQV 6m4g G 2.80 BS01 NUC I 1 S20 R24 S32 S1 R5 S13 SRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVIEYLTAKVLELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQV 6m4h A 3.90 BS01 NUC I 1 R63 K64 L65 R69 R83 K115 R4 K5 L6 R10 R24 K56 LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGE 6m4h C 3.90 BS02 NUC J 1 S20 R21 S32 R46 S1 R2 S13 R27 SRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVIEYLTAKVLELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQV 6m4h E 3.90 BS01 NUC I 1 R63 R72 R83 F84 R116 V117 T118 M120 R4 R13 R24 F25 R57 V58 T59 M61 LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGE 6m4h G 3.90 BS01 NUC I 1 S20 R21 R46 S1 R2 R27 SRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVIEYLTAKVLELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQV 6m6p A 2.27 BS02 BGC B 1 W50 G51 N52 R88 W130 W29 G30 N31 R67 W109 NWTLVWQDEFTNGISSDWVFETGNGNSGWGNNELQYYRRENATVENGNLVITAKRESIGGYNYTSTRMKTQGRKSWKYGKVEARIAMPSFMGSWPAFWMLGDNISSVGWPACGAIDIMEHVNTEAQTHGTIHWQDHNNTYANYSGSIPVSSVTSYHIYTIEWDASVIKWFVDGNLYHEASIANGVNGTSEFHNNFFILLNMAIGGNWPGFNIDNNAFPARMLVDYVRVYQK 6m6p A 2.27 BS03 BGC B 2 N47 G51 N26 G30 NWTLVWQDEFTNGISSDWVFETGNGNSGWGNNELQYYRRENATVENGNLVITAKRESIGGYNYTSTRMKTQGRKSWKYGKVEARIAMPSFMGSWPAFWMLGDNISSVGWPACGAIDIMEHVNTEAQTHGTIHWQDHNNTYANYSGSIPVSSVTSYHIYTIEWDASVIKWFVDGNLYHEASIANGVNGTSEFHNNFFILLNMAIGGNWPGFNIDNNAFPARMLVDYVRVYQK 6p3d A 2.11 BS01 0LI A 1 V471 A481 V482 K483 E501 L505 I513 L514 I527 T529 Q530 W531 C532 I572 I573 H574 R575 F583 I592 G593 D594 F595 V26 A36 V37 K38 E56 L60 I68 L69 I82 T84 Q85 W86 C87 I127 I128 H129 R130 F138 I147 G148 D149 F150 2.7.11.1 32873792 KMDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATESGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELS 6p7g A 2.65 BS01 E7M A 1 A481 K483 E501 L505 L514 T529 Q530 W531 C532 H574 G593 D594 F595 L597 A33 K35 E53 L57 L66 T81 Q82 W83 C84 H126 G145 D146 F147 L149 2.7.11.1 32873792 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARE 6p7g B 2.65 BS01 E7M B 1 A481 V482 K483 N500 E501 V504 L505 L514 T529 Q530 W531 C532 I573 H574 R575 G593 D594 F595 A33 V34 K35 N52 E53 V56 L57 L66 T81 Q82 W83 C84 I125 H126 R127 G145 D146 F147 2.7.11.1 32873792 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATEKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 6p7g C 2.65 BS01 E7M C 1 A481 K483 N500 E501 V504 L505 L514 T529 Q530 W531 C532 I573 H574 R575 G593 D594 F595 A33 K35 N52 E53 V56 L57 L66 T81 Q82 W83 C84 I125 H126 R127 G145 D146 F147 2.7.11.1 32873792 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 6q0d A 2.05 BS01 P8M A 1 R105 L108 N137 P138 V139 D140 I141 R168 E191 H192 G193 D194 A237 Y238 I241 T247 L322 I325 R105 L108 N137 P138 V139 D140 I141 R168 E191 H192 G193 D194 A237 Y238 I241 T247 L322 I325 1.1.1.27 32902275 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 6q0d A 2.05 BS02 NAI A 1 G28 A29 V30 D51 V52 I53 T94 A95 G96 R98 I115 I119 V135 S136 N137 L164 H192 T247 I251 G28 A29 V30 D51 V52 I53 T94 A95 G96 R98 I115 I119 V135 S136 N137 L164 H192 T247 I251 1.1.1.27 32902275 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 6q0d D 2.05 BS01 P8M D 1 R105 L108 V109 N137 P138 V139 D140 I141 L164 R168 E191 H192 G193 A237 Y238 I241 T247 L322 I325 R105 L108 V109 N137 P138 V139 D140 I141 L164 R168 E191 H192 G193 A237 Y238 I241 T247 L322 I325 1.1.1.27 32902275 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 6q0d E 2.05 BS01 P8M E 1 R105 L106 L108 V109 N137 P138 V139 D140 I141 L164 R168 E191 H192 G193 A237 Y238 I241 T247 L322 I325 R105 L106 L108 V109 N137 P138 V139 D140 I141 L164 R168 E191 H192 G193 A237 Y238 I241 T247 L322 I325 1.1.1.27 32902275 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 6q13 A 2.00 BS01 NAI A 1 V25 G28 A29 V30 D51 V52 I53 T94 A95 G96 R98 I115 I119 V135 S136 N137 S160 H192 T247 I251 V25 G28 A29 V30 D51 V52 I53 T94 A95 G96 R98 I115 I119 V135 S136 N137 S160 H192 T247 I251 1.1.1.27 32902275 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 6q13 B 2.00 BS02 P8V B 1 V109 N137 P138 V139 D140 I141 L164 R168 E191 H192 A237 Y238 I241 T247 L322 I325 V109 N137 P138 V139 D140 I141 L164 R168 E191 H192 A237 Y238 I241 T247 L322 I325 1.1.1.27 32902275 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 6q13 D 2.00 BS01 NAI D 1 V25 G28 A29 V30 D51 V52 I53 T94 A95 G96 I115 F118 I119 V135 S136 N137 L164 H192 T247 I251 V25 G28 A29 V30 D51 V52 I53 T94 A95 G96 I115 F118 I119 V135 S136 N137 L164 H192 T247 I251 1.1.1.27 32902275 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 6q1r A 2.70 BS01 PLP A 1 R50 K149 Y153 E182 G183 P184 R185 S186 T187 L213 G215 T216 T217 S253 R51 K150 Y154 E183 G184 P185 R186 S187 T188 L207 G209 T210 T211 S247 AMVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSAPTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLIASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR 6q1r B 2.70 BS01 PLP B 1 R50 K149 Y153 E182 G183 P184 R185 S186 G215 T216 T217 S252 S253 R52 K151 Y155 E184 G185 P186 R187 S188 G210 T211 T212 S247 S248 NAMVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSAPTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLIASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR 6q1r C 2.70 BS01 PLP C 1 H47 R50 K149 Y153 E182 G183 P184 S186 T187 L213 T216 T217 S252 S253 H48 R51 K150 Y154 E183 G184 P185 S187 T188 L208 T211 T212 S247 S248 AMVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSAPTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLIASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDNPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR 6q1s A 2.30 BS01 PMP A 1 R50 Y153 E182 G183 P184 R185 S186 T187 L213 G215 T216 T217 S252 S253 R51 Y154 E183 G184 P185 R186 S187 T188 L207 G209 T210 T211 S246 S247 AMVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSAPTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLIASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR 6q1s A 2.30 BS02 AKG A 1 F31 T33 R115 K149 S252 S253 M254 T255 F32 T34 R116 K150 S246 S247 M248 T249 AMVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSAPTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLIASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR 6q1s B 2.30 BS01 PMP B 1 R50 K149 Y153 E182 G183 P184 R185 S186 T187 L213 T216 T217 V251 S252 S253 R52 K151 Y155 E184 G185 P186 R187 S188 T189 L208 T211 T212 V246 S247 S248 NAMVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSAPTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLIASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR 6q1s B 2.30 BS02 AKG B 1 R115 M157 R185 M254 T255 R117 M159 R187 M249 T250 NAMVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSAPTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLIASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR 6q1s C 2.30 BS02 AKG C 1 R115 S252 M254 T255 R116 S246 M248 T249 AMVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSAPTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLIASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR 6q1s D 2.30 BS01 PMP D 1 R50 Y153 P184 R185 S186 T187 L213 G215 T216 T217 S252 S253 R51 Y154 P185 R186 S187 T188 L207 G209 T210 T211 S246 S247 AMVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSAPTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLIASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR 6q1s D 2.30 BS02 AKG D 1 T33 R115 S252 M254 T255 T34 R116 S246 M248 T249 AMVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSAPTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLIASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR 6suw E 2.66 BS02 CA E 1 K16 R22 K10 R16 32878987 STHEPLEVLKEETVNRHRAIVSVMAELEAVDWYDQRVDASTDPELTAILAHNRDEEKEHAAMTLEWLRRNDAKWAEHLRTYLFTEGPITA 6suw E 2.66 BS04 CA E 3 F89 E91 F83 E85 32878987 STHEPLEVLKEETVNRHRAIVSVMAELEAVDWYDQRVDASTDPELTAILAHNRDEEKEHAAMTLEWLRRNDAKWAEHLRTYLFTEGPITA 6suw F 2.66 BS01 CA E 1 D40 R59 D34 R53 32878987 STHEPLEVLKEETVNRHRAIVSVMAELEAVDWYDQRVDASTDPELTAILAHNRDEEKEHAAMTLEWLRRNDAKWAEHLRTYLFTEGPITA 6sv1 D 2.19 BS02 CA D 1 D40 D44 R59 D34 D38 R53 32878987 STHEPLEVLKEETVNRHRAIVSVMEELAAVDWYDQRVDASTDPELTAILAHNRDEEKEHAAMTLEWLRRNDAKWAEHLRTYLFTEGPITAA 6sv1 T 2.19 BS02 CA T 1 L12 E13 L15 L6 E7 L9 32878987 STHEPLEVLKEETVNRHRAIVSVMEELAAVDWYDQRVDASTDPELTAILAHNRDEEKEHAAMTLEWLRRNDAKWAEHLRTYLFTEGPITAA 6tck A 1.60 BS01 N1N A 1 N54 S55 E58 D81 R84 G85 I86 P87 A98 I102 R144 T173 I175 N38 S39 E42 D65 R68 G69 I70 P71 A82 I86 R105 T134 I136 5.6.2.2 GQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYE 6tt7 2 3.50 BS01 P5S 2 1 I34 R38 I34 R38 DIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFA 6tt7 3 3.50 BS01 P5S 2 1 T27 I34 T27 I34 DIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFA 6tt7 4 3.50 BS01 P5S 2 1 A23 I34 R38 A23 I34 R38 DIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFA 6tt7 6 3.50 BS01 P5S 2 1 T27 R38 T27 R38 DIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFA 6tt7 8 3.50 BS01 S12 T 1 I9 A13 I9 A13 DIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFA 6tt7 C 3.50 BS02 ADP C 1 Q172 G174 K175 T176 S177 F357 R362 P363 Q430 G431 Q432 Q165 G167 K168 T169 S170 F350 R355 P356 Q423 G424 Q425 VSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKARRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGTDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVISQHQTLLGKIRTDGKISEEADAKLKEIVTNFLAGFEA 6tt7 A 3.50 BS01 ADP A 1 R171 Q172 G174 K175 T176 S177 E328 Q432 R169 Q170 G172 K173 T174 S175 E326 Q430 TGTAEVSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKARRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGTDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVISQHQTLLGKIRTDGKISEEADAKLKEIVTNFLAGFE 6tt7 D 3.50 BS01 ADP D 1 G159 A160 G161 V162 G163 K164 T165 V166 Y347 F420 A423 F426 G151 A152 G153 V154 G155 K156 T157 V158 Y339 F412 A415 F418 7.1.2.2 GGATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPIKTKQFAAIHAEAPEFVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHLGKLVPLKETIKGFQQILAGEFDHLPEQAFYMVGPIEEAVAKADKLAE 6tt7 F 3.50 BS01 ADP C 1 Y370 R374 Y362 R366 7.1.2.2 GGATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPIKTKQFAAIHAEAPEFVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHLGKLVPLKETIKGFQQILAGEFDHLPEQAFYMVGPIEEAVAKADKLAEEHS 6tt7 F 3.50 BS02 ADP F 1 G161 G163 K164 T165 V166 E190 Y347 F420 A423 F426 T427 G153 G155 K156 T157 V158 E182 Y339 F412 A415 F418 T419 7.1.2.2 GGATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPIKTKQFAAIHAEAPEFVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHLGKLVPLKETIKGFQQILAGEFDHLPEQAFYMVGPIEEAVAKADKLAEEHS 6tt7 T 3.50 BS01 S12 T 1 E66 L70 K71 E65 L69 K70 VPPVQVSPLIKLGRYSALFLGMAYGAKRYNYLKPRAEEERRLAAEEKKKRDEQKRIERELAEAQEDTILK 6u4i A 1.55 BS01 EQU A 1 Y16 D40 G60 F86 M90 L99 D103 M116 A118 W120 Y14 D38 G58 F84 M88 L97 D101 M114 A116 W118 5.3.3.1 LPTAQEVQGLMARYIELVDVGDIEAIVQMYADDATVEDPFGQPPIHGREQIAAFYRQGLGGGKVRACLTGPVRASHNGCGAMPFRVEMVWNGQPCALDVIDVMRFDEHGRIQTMQAYWSEVNLSVR 6u4i B 1.55 BS01 EQU B 1 Y16 V20 D40 G60 F86 V88 M90 L99 D103 M116 A118 W120 Y16 V20 D40 G60 F86 V88 M90 L99 D103 M116 A118 W120 5.3.3.1 MNLPTAQEVQGLMARYIELVDVGDIEAIVQMYADDATVEDPFGQPPIHGREQIAAFYRQGLGGGKVRACLTGPVRASHNGCGAMPFRVEMVWNGQPCALDVIDVMRFDEHGRIQTMQAYWSEVNLSVR 6ubq A 1.30 BS01 ASD A 1 Y16 V20 D40 Y57 G60 F86 V88 M90 L99 D103 W120 Y14 V18 D38 Y55 G58 F84 V86 M88 L97 D101 W118 5.3.3.1 LPTAQEVQGLMARYIELVDVGDIEAIVQMYADDATVEDPFGQPPIHGREQIAAFYRQGLGGGKVRACLTGPVRASHNGCGAMPFRVEMVWNGQPCALDVIDVMRFDEHGRIQTMQAYWSEVNLSVR 6ubq B 1.30 BS01 ASD B 1 Y16 V20 D40 F56 Y57 F86 V88 M90 L99 D103 W120 Y16 V20 D40 F56 Y57 F86 V88 M90 L99 D103 W120 5.3.3.1 MNLPTAQEVQGLMARYIELVDVGDIEAIVQMYADDATVEDPFGQPPIHGREQIAAFYRQGLGGGKVRACLTGPVRASHNGCGAMPFRVEMVWNGQPCALDVIDVMRFDEHGRIQTMQAYWSEVNLSVR 6ucn A 1.32 BS01 EQU A 1 Y16 D40 L99 D103 M116 W120 Y14 D38 L97 D101 M114 W118 5.3.3.1 LPTAQEVQGLMARYIELVDVGDIEAIVQMYADDATVEDPFGQPPIHGREQIAAFYRQGLGGGKVRACLTGPVRASHNGCGAMPFRVEMVWNGQPCALDVIDVMRFDEHGRIQTMQAYWSEVNLSVR 6ucn B 1.32 BS01 EQU B 1 Y16 D40 F86 M90 L99 D103 M116 A118 W120 Y16 D40 F86 M90 L99 D103 M116 A118 W120 5.3.3.1 MNLPTAQEVQGLMARYIELVDVGDIEAIVQMYADDATVEDPFGQPPIHGREQIAAFYRQGLGGGKVRACLTGPVRASHNGCGAMPFRVEMVWNGQPCALDVIDVMRFDEHGRIQTMQAYWSEVNLSVRE 6ucy A 1.15 BS01 ASD A 1 Y16 V20 D40 F56 Y57 G60 L61 M90 L99 D103 M116 A118 W120 Y16 V20 D40 F56 Y57 G60 L61 M90 L99 D103 M116 A118 W120 5.3.3.1 MNLPTAQEVQGLMARYIELVDVGDIEAIVQMYADDATVEDPFGQPPIHGREQIAAFYRQGLGGGKVRACLTGPVRASHNGCGAMPFRVEMVWNGQPCALDVIDVMRFDEHGRIQTMQAYWSEVNLSVRE 6udc A 2.10 BS01 BTN A 1 N23 L25 S27 Y43 S45 V47 G48 N49 A50 W79 S88 T90 W92 W108 D128 N10 L12 S14 Y30 S32 V34 G35 N36 A37 W66 S75 T77 W79 W95 D114 EAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLTSGTTEANAWKSTLVGHDTFTKV 6udc B 2.10 BS01 BTN B 1 N23 L25 S27 Y43 S45 V47 N49 W79 S88 T90 W108 D128 N8 L10 S12 Y28 S30 V32 N34 W64 S73 T75 W93 D112 GITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLTSGTTEANAWKSTLVGHDTFTKVK 6udc D 2.10 BS01 BTN D 1 N23 L25 S27 Y43 S45 V47 N49 W79 A86 S88 T90 W92 W108 D128 N9 L11 S13 Y29 S31 V33 N35 W65 A72 S74 T76 W78 W94 D113 AGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLTSGTTEANAWKSTLVGHDTFTKVKPS 6udl A 2.85 BS01 HEM A 1 R106 M121 S122 W131 R135 L142 I198 D313 L314 A317 G318 T321 V322 F376 F381 V382 T385 I386 H388 Q411 I449 F450 G451 R455 K456 C457 I458 G459 I462 A463 R71 M86 S87 W96 R100 L107 I163 D270 L271 A274 G275 T278 V279 F333 F338 V339 T342 I343 H345 Q368 I406 F407 G408 R412 K413 C414 I415 G416 I419 A420 1.14.14.1,4.2.1.152 GLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 6udl A 2.85 BS02 Q4M A 1 S116 F123 N222 F224 F258 L312 G316 A317 F319 T321 V382 I386 L496 S81 F88 N187 F189 F223 L269 G273 A274 F276 T278 V339 I343 L453 1.14.14.1,4.2.1.152 GLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 6udl B 2.85 BS02 Q4M B 1 I115 S116 F123 N222 F224 L254 N255 F258 L312 D313 G316 A317 F319 T321 V382 L496 I80 S81 F88 N187 F189 L219 N220 F223 L277 D278 G281 A282 F284 T286 V347 L461 1.14.14.1,4.2.1.152 GLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 6udl C 2.85 BS01 HEM C 1 R106 S122 R135 I198 D313 L314 A317 G318 T321 V322 A325 F376 F381 V382 T385 I386 H388 Q411 I449 F450 G451 R455 K456 C457 I458 G459 I462 A463 R71 S87 R100 I163 D267 L268 A271 G272 T275 V276 A279 F330 F335 V336 T339 I340 H342 Q365 I403 F404 G405 R409 K410 C411 I412 G413 I416 A417 1.14.14.1,4.2.1.152 GLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 6udm B 3.08 BS02 Q4P B 1 I115 S116 F123 N222 F224 L254 N255 F258 G316 A317 F319 T321 V382 L496 T497 I79 S80 F87 N186 F188 L218 N219 F222 G280 A281 F283 T285 V346 L460 T461 1.14.14.1,4.2.1.152 LKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 6udm C 3.08 BS02 Q4P C 1 I115 F123 N222 F224 N255 F258 G316 A317 F319 T321 L496 T497 I79 F87 N186 F188 N219 F222 G272 A273 F275 T277 L452 T453 1.14.14.1,4.2.1.152 LKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 6udm D 3.08 BS02 Q4P D 1 I115 S116 F123 N222 F224 F258 G316 A317 F319 T321 V382 I386 T497 I79 S80 F87 N186 F188 F222 G269 A270 F272 T274 V335 I339 T450 1.14.14.1,4.2.1.152 LKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 6upa B 2.51 BS01 GTP B 1 T51 G52 L53 G54 K55 S56 T57 P71 A72 K185 D187 I238 G239 R254 Y256 T11 G12 L13 G14 K15 S16 T17 P29 A30 K138 D140 I191 G192 R207 Y209 FCFNILCVGETGLGKSTLMDTLFNTKFEPATHTQPGVQLQSNTYDLRLKLTIVSTVGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRVLHTYHDSRIHVCLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADAISKSELTKFKIKITSELVSNGVQIYQFPTDDESVAEINGTMNAHLPFAVIGSTEELKIGNKMMRARQYPWGTVQVENEAHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEE 6upa B 2.51 BS02 GDP A 1 T158 H160 A188 E193 T111 H113 A141 E146 FCFNILCVGETGLGKSTLMDTLFNTKFEPATHTQPGVQLQSNTYDLRLKLTIVSTVGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRVLHTYHDSRIHVCLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADAISKSELTKFKIKITSELVSNGVQIYQFPTDDESVAEINGTMNAHLPFAVIGSTEELKIGNKMMRARQYPWGTVQVENEAHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEE 6upa A 2.51 BS01 GTP B 1 H158 T186 E191 H114 T142 E147 EFTLMVVGESGLGKSTLINSLFLTDLYPERVIPGAAEKIERTVQIEASTVERLTVVDTPGYGDAINCRDCFKTIISYIDEQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGLKPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHNIKIYHLPDFKEQTRLLKASIPFSVVGSNQLIKKVRGRLYPWGVVEVENPEHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKR 6upa A 2.51 BS02 GDP A 1 S46 G47 L48 G49 K50 S51 T52 R66 K183 D185 V240 G241 R256 Y258 S10 G11 L12 G13 K14 S15 T16 R30 K139 D141 V188 G189 R200 Y202 EFTLMVVGESGLGKSTLINSLFLTDLYPERVIPGAAEKIERTVQIEASTVERLTVVDTPGYGDAINCRDCFKTIISYIDEQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGLKPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHNIKIYHLPDFKEQTRLLKASIPFSVVGSNQLIKKVRGRLYPWGVVEVENPEHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKR 6upq A 1.86 BS01 GDP A 1 G47 L48 G49 K50 S51 T52 R66 K183 D185 V240 G241 R256 Y258 G12 L13 G14 K15 S16 T17 R31 K148 D150 V205 G206 R221 Y223 FEFTLMVVGESGLGKSTLINSLFLTDLYPERVIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINCRDCFKTIISYIDEQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGLKPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHNIKIYHLPDAESDEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGRLYPWGVVEVENPEHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLK 6upq A 1.86 BS02 GTP B 1 H158 T186 E191 H123 T151 E156 FEFTLMVVGESGLGKSTLINSLFLTDLYPERVIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINCRDCFKTIISYIDEQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGLKPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHNIKIYHLPDAESDEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGRLYPWGVVEVENPEHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLK 6upq B 1.86 BS01 GDP A 1 T157 H159 T187 E192 T118 H120 T148 E153 FCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRC 6upq B 1.86 BS02 GTP B 1 T50 G51 I52 G53 K54 S55 T56 P70 A71 K184 D186 V237 G238 R253 Y255 T11 G12 I13 G14 K15 S16 T17 P31 A32 K145 D147 V184 G185 R200 Y202 FCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRC 6upr B 2.30 BS01 GDP A 1 T160 H162 T190 E195 T119 H121 T149 E154 GFSFNILCVGETGIGKSTLMNTLFNTTFETEEASHHEACVRLRPQTYDLQESNVQLKLTIVDAVGFGDQINKDESYRPIVDYIDAQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFPTDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQ 6upr B 2.30 BS02 GTP B 1 T53 G54 I55 G56 K57 S58 T59 A74 K187 D189 V240 G241 R256 Y258 T12 G13 I14 G15 K16 S17 T18 A33 K146 D148 V199 G200 R215 Y217 GFSFNILCVGETGIGKSTLMNTLFNTTFETEEASHHEACVRLRPQTYDLQESNVQLKLTIVDAVGFGDQINKDESYRPIVDYIDAQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFPTDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQ 6upr B 2.30 BS03 MG B 1 S58 T71 S17 T30 GFSFNILCVGETGIGKSTLMNTLFNTTFETEEASHHEACVRLRPQTYDLQESNVQLKLTIVDAVGFGDQINKDESYRPIVDYIDAQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFPTDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQ 6uqq A 2.75 BS01 GDP A 1 S59 G60 L61 G62 K63 S64 T65 S84 K195 D197 V249 G250 R265 Y267 S11 G12 L13 G14 K15 S16 T17 S36 K147 D149 V198 G199 R214 Y216 FEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEHKIKIYEFPDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAA 6uqq B 2.75 BS01 GDP B 1 G60 L61 G62 K63 S64 T65 K195 D197 V249 G250 R265 G12 L13 G14 K15 S16 T17 K131 D133 V178 G179 R191 FEFTLMVVGESGLGKSTLINSLFLTDLYTVQVEQSKVLIKVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEHKIKIYEFPNKLVKKIKDRLPLAVVGSNTIIEVRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAA 6uqq C 2.75 BS01 GDP C 1 G71 L72 G73 K74 S75 T76 K89 K208 D210 V264 G265 R280 Y282 G13 L14 G15 K16 S17 T18 K31 K150 D152 V206 G207 R222 Y224 GFDFNIMVVGQSGLGKSTLVNTLFKSQVSRKASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKYPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRLNDNGGLPPV 6ve8 A 1.75 BS01 MET A 1 R57 F108 D126 A128 R133 Q174 V175 G176 S177 Y178 E218 Y221 R9 F60 D78 A80 R85 Q126 V127 G128 S129 Y130 E170 Y173 RLRIGVPDRASFKEFVSRLDGSNKVQGYAIDVFEAAVKLISYPVPHEFVLFGDGLKNPNFNEFVNNVTIGVFDAVVGDIAIVTKRTRIVDFTQPYIESGLVVVAPVGTPIRGVDTLISSSGRVGFQVGSYAENYMIDELNIARSRLVPLGSPKEYAAALQNGTVAAIVDERPYVDLFLSEFCGFAIRGQEFTRSGWGFAFPRDSPLAIDMSTAILGLSETGQLQKIHDKWLSRSNCS 6vea A 1.58 BS01 GLY A 1 F108 D126 A128 R133 S177 Y178 E218 Y221 F62 D80 A82 R87 S131 Y132 E172 Y175 GRRLRIGVPDRASFKEFVSRLDGSNKVQGYAIDVFEAAVKLISYPVPHEFVLFGDGLKNPNFNEFVNNVTIGVFDAVVGDIAIVTKRTRIVDFTQPYIESGLVVVAPVGTPIRGVDTLISSSGRVGFQVGSYAENYMIDELNIARSRLVPLGSPKEYAAALQNGTVAAIVDERPYVDLFLSEFCGFAIRGQEFTRSGWGFAFPRDSPLAIDMSTAILGLSETGQLQKIHDKWLSRSNCSN 6vp9 A 3.46 BS01 III C 1 E25 Y27 H73 T75 L77 F111 Y137 Y138 S139 A140 E24 Y26 H72 T74 L76 F110 Y136 Y137 S138 A139 2.3.1.254 32885784 TTLRAFTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASGEPDEDAYDMRKALSRDT 6vp9 A 3.46 BS02 CMC A 1 T24 L77 S78 V79 R84 R85 G87 L88 A89 A90 F111 V118 A119 M122 Y123 Q125 T23 L76 S77 V78 R83 R84 G86 L87 A88 A89 F110 V117 A118 M121 Y122 Q124 2.3.1.254 32885784 TTLRAFTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASGEPDEDAYDMRKALSRDT 6w0m A 2.37 BS01 NUC B 1 G42 F144 S147 S148 N149 N150 N151 I152 L243 P244 G245 G247 T248 Q249 V250 M257 P266 D268 H270 Q315 F319 G34 F133 S136 S137 N138 N139 N140 I141 L232 P233 G234 G236 T237 Q238 V239 M246 P255 D257 H259 Q304 F308 3.2.2.-,4.2.99.18 32895378 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQQVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARCVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTQVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQ 6w0m A 2.37 BS02 NUC C 1 N149 R154 R197 G200 G202 Y203 R204 S286 A288 S292 N138 R143 R186 G189 G191 Y192 R193 S275 A277 S281 3.2.2.-,4.2.99.18 32895378 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQQVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARCVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTQVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQ 6w0m A 2.37 BS03 MG A 1 R14 L22 T76 V77 S86 R87 P88 R6 L14 T68 V69 S75 R76 P77 3.2.2.-,4.2.99.18 32895378 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQQVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARCVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTQVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQ 6w0m A 2.37 BS05 S5Y A 1 Y203 C207 G245 Y192 C196 G234 3.2.2.-,4.2.99.18 32895378 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQQVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARCVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTQVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQ 6w0r A 2.35 BS01 NUC B 1 N149 P244 G245 G247 K249 V250 D268 V269 N138 P233 G234 G236 K238 V239 D257 V258 3.2.2.-,4.2.99.18 32895378 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQQVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARCVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADL 6w0r A 2.35 BS02 NUC C 1 N149 N151 R154 Y203 R204 N138 N140 R143 Y192 R193 3.2.2.-,4.2.99.18 32895378 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQQVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARCVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADL 6w0r A 2.35 BS03 S5Y B 1 Y203 R204 C207 G245 Y192 R193 C196 G234 3.2.2.-,4.2.99.18 32895378 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQQVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARCVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADL 6w0w A 2.80 BS01 RZA A 1 A224 A226 E227 G229 A244 F245 P246 P247 T253 F260 C282 A285 G286 C289 A222 A224 E225 G227 A242 F243 P244 P245 T251 F258 C280 A283 G284 C287 2.7.1.3 GSQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV 6w0x A 2.38 BS01 S6J A 1 R108 A224 A226 E227 G229 A244 F245 P246 P247 V250 T253 A256 F260 C282 G286 C289 R106 A222 A224 E225 G227 A242 F243 P244 P245 V248 T251 A254 F258 C280 G284 C287 2.7.1.3 GSQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV 6w0y A 2.54 BS01 S6S A 1 R108 A224 A226 E227 G229 A244 F245 P246 P247 T253 L254 G255 A256 G257 F260 C282 G286 C289 R106 A222 A224 E225 G227 A242 F243 P244 P245 T251 L252 G253 A254 G255 F258 C280 G284 C287 2.7.1.3 GSQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV 6w0z A 2.30 BS01 S6D A 1 R108 A224 A226 E227 A244 P246 T253 L254 G255 A256 G257 F260 C282 G286 C289 R106 A222 A224 E225 A242 P244 T251 L252 G253 A254 G255 F258 C280 G284 C287 2.7.1.3 GSQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV 6w13 A 2.38 BS01 NUC B 1 N149 P244 G245 V246 G247 T248 K249 V250 D268 V269 N138 P233 G234 V235 G236 T237 K238 V239 D257 V258 3.2.2.-,4.2.99.18 32895378 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQQVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARCVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADWICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLR 6w13 A 2.38 BS03 MG A 1 Q43 S44 Q135 C140 S143 F144 Q35 S36 Q124 C129 S132 F133 3.2.2.-,4.2.99.18 32895378 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQQVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARCVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADWICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLR 6w13 A 2.38 BS05 MG A 3 H112 W113 W307 G308 P309 Y310 H101 W102 W296 G297 P298 Y299 3.2.2.-,4.2.99.18 32895378 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQQVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARCVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADWICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLR 6w13 A 2.38 BS06 MG A 4 L187 A188 G189 V192 S209 R213 L176 A177 G178 V181 S198 R202 3.2.2.-,4.2.99.18 32895378 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQQVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARCVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADWICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLR 6w13 A 2.38 BS07 S5Y B 1 Y203 R206 C207 Y192 R195 C196 3.2.2.-,4.2.99.18 32895378 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQQVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARCVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADWICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLR 6wgt A 3.40 BS01 7LD A 1 W151 D155 V156 G238 S242 W336 F339 F340 N343 V366 W80 D84 V85 G162 S166 W314 F317 F318 N321 V344 QEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPISRFNSRTKAFLKIIAVWTISVGISMPIPVFGLSKVFKEGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKEDKSPDSPEMKDFRHGFDILVGQIDDAKLAKEAQAAAEQLKTTRNAYIQKYLTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYASSAVNPLVYTLFNKTYRSAFSRYIQCQY 6wgt A 3.40 BS02 CLR A 1 P338 I341 T342 M345 C353 N354 V357 I358 L361 P316 I319 T320 M323 C331 N332 V335 I336 L339 QEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPISRFNSRTKAFLKIIAVWTISVGISMPIPVFGLSKVFKEGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKEDKSPDSPEMKDFRHGFDILVGQIDDAKLAKEAQAAAEQLKTTRNAYIQKYLTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYASSAVNPLVYTLFNKTYRSAFSRYIQCQY 6wgt A 3.40 BS03 CLR A 2 M114 S115 L157 F193 I196 W200 M43 S44 L86 F120 I123 W127 QEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPISRFNSRTKAFLKIIAVWTISVGISMPIPVFGLSKVFKEGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKEDKSPDSPEMKDFRHGFDILVGQIDDAKLAKEAQAAAEQLKTTRNAYIQKYLTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYASSAVNPLVYTLFNKTYRSAFSRYIQCQY 6wgt B 3.40 BS01 7LD B 1 W151 D155 V156 S159 L228 L229 G238 S239 S242 W336 F339 N343 Y370 W82 D86 V87 S90 L150 L151 G160 S161 S164 W294 F297 N301 Y328 HLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNNSRTKAFLKIIAVWTISVGISMPIPVFGLQSKVFKEGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKNAAQVKDALTKMRAAALDAQKAPEMKDFRHGFDILVGQIDDAAQAAAEQLKTTRNAYIQKYLTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYASSAVNPLVYTLFNKTYRSAFSRYIQCQYK 6wgt C 3.40 BS01 7LD C 1 W151 D155 S159 L228 L229 G238 S239 S242 W336 F339 F340 N343 N363 V366 W83 D87 S91 L156 L157 G166 S167 S170 W312 F315 F316 N319 N339 V342 LHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNHSRFNSRTKAFLKIIAVWTISVGISMPIPVFLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPDSPEMKDFRHGFDILVGQIDDALKKVKEAQAAAEQLKTTRNAYIQKYLTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYASSAVNPLVYTLFNKTYRSAFSRYIQCQYK 6wh4 A 3.40 BS01 89F A 1 W151 D155 V156 S159 T160 I163 L229 V235 G238 W336 F340 W81 D85 V86 S89 T90 I93 L156 V162 G165 W315 F319 LQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLSKVFKEGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKSPDSPEMKDFRHGFDILVGQIDDALKLAKEAQAAAEQLKTTRNAYIQKYLTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYASSAVNPLVYTLFNKTYRSAFSRYIQCQY 6wh4 A 3.40 BS02 CLR A 1 M97 Y394 M27 Y373 LQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLSKVFKEGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKSPDSPEMKDFRHGFDILVGQIDDALKLAKEAQAAAEQLKTTRNAYIQKYLTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYASSAVNPLVYTLFNKTYRSAFSRYIQCQY 6wh4 B 3.40 BS01 89F B 1 W151 D155 V156 S159 L229 V235 G238 S239 S242 W336 F339 F340 N343 W83 D87 V88 S91 L150 V156 G159 S160 S163 W294 F297 F298 N301 LHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQSRTKAFLKIIAVWTISVGISMPIPVFGLQSKVFKEGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKNAAQVKDALTKMRAAALDAQKASPEMKDFRHGFDILVGQIDDAAQAAAEQLKTTRNAYIQKYLTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYASSAVNPLVYTLFNKTYRSAFSRYIQCQYK 6wh4 C 3.40 BS01 89F C 1 W151 D155 V156 S159 L229 V235 G238 S239 S242 W336 F340 Y370 W83 D87 V88 S91 L156 V162 G165 S166 S169 W313 F317 Y347 LHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNHSRFNSRTKAFLKIIAVWTISVGISMPIPVFQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPDSPEMKDFRHGFDILVGQIDDALKLKVKEAQAAAEQLKTTRNAYIQKYLTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYASSAVNPLVYTLFNKTYRSAFSRYIQCQ 6wh4 C 3.40 BS02 CLR C 1 L94 M97 Y394 I395 L26 M29 Y371 I372 LHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNHSRFNSRTKAFLKIIAVWTISVGISMPIPVFQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPDSPEMKDFRHGFDILVGQIDDALKLKVKEAQAAAEQLKTTRNAYIQKYLTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYASSAVNPLVYTLFNKTYRSAFSRYIQCQ 6wh4 C 3.40 BS03 NDS C 1 N1011 Y1101 K1104 N203 Y282 K285 LHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNHSRFNSRTKAFLKIIAVWTISVGISMPIPVFQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPDSPEMKDFRHGFDILVGQIDDALKLKVKEAQAAAEQLKTTRNAYIQKYLTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYASSAVNPLVYTLFNKTYRSAFSRYIQCQ 6wha A 3.36 BS01 U0G A 1 D155 S159 S242 F339 F340 G369 Y370 D65 S69 S151 F196 F197 G220 Y221 VIILTIAGNILVIMAVLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSR 6xcb A 1.74 BS02 UZY A 1 F163 E164 C165 H223 E224 H227 R231 E262 Y366 F158 E159 C160 H215 E216 H219 R223 E254 Y358 3.4.24.69 32886509 QFVNKQFNYKDPVNGVDIAYIKIPNVQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQSYRSEELNLVIIGPSADIIQFECKSFGLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGL 6xcc A 1.90 BS02 UZV A 1 F163 E164 C165 H223 E224 H227 E262 Y366 F163 E164 C165 H223 E224 H227 E262 Y366 3.4.24.69 32886509 MQFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLF 6xce A 2.50 BS01 UZM A 1 I161 Q162 F163 E164 C165 F194 T215 T220 H223 E224 H227 E262 R363 D370 I161 Q162 F163 E164 C165 F194 T215 T220 H223 E224 H227 E262 R363 D370 3.4.24.69 32886509 MQFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLF 6xcf A 1.68 BS01 UZP A 1 V70 I161 Q162 F163 F192 T193 F194 H223 E224 H227 E262 R363 Y366 D370 V373 V65 I156 Q157 F158 F187 T188 F189 H218 E219 H222 E257 R358 Y361 D365 V368 3.4.24.69 32886509 MQFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGL 6xd0 A 2.01 BS03 V0M A 1 F398 K401 V402 W418 R481 F485 N492 V603 W795 I797 F128 K131 V132 W140 R187 F191 N198 V309 W501 I503 DNMDVIGERIKRIKEEHNSTWHYDDENPYKTWAYHGSYEVKATGSASSMINGVVKLLTKPWDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTPRPLPGTRKVMEITAEWLWRTLGRNKRPRLCTREEFTKKVRTNAAMQWDSAKAAVEDEEFWKLVDRERELHKLGKCGSCVYNMSRAIWYMWLGVRYLEFEALGFLNEDHWFSRENSYSGVEGEGLHKLGYILRDISKIPGGAMYADDTAGWDTRITEDDLHNEEKIIQQMDPEHRQLANAIFKLTYQNKVVKVQRPTPTGTVMDIISRKDQRGSGQVGTYGLNTFTNMEAQLVRQMEGEGVLTKADLENPHLLEKKITQWLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGKVRKDIPQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIGRARISQGAGWSLRETACLGKAYAQMWSLMYFHRRDLRLASNAICSAVPVHWVPTSRTTWSIHAHHQWMTTEDMLTVWNRVWIEENPWMEDKTPVTTWENVPYLGKREDQWCGSLIGLTSRATWAQNIPTAIQQVRSLIGNEEFLDYM 6xd1 A 1.95 BS03 V0J A 1 V310 K311 T313 D419 S420 A421 G455 K456 R457 E458 F464 S470 R471 I473 W474 W477 K578 V38 K39 T41 D135 S136 A137 G171 K172 R173 E174 F180 S186 R187 I189 W190 W193 K294 MDVIGERIKRIKEEHNSTWHYDDENPYKTWAYHGSYEVKATGSASSMINGVVKLLTKPWDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTPRPLPGTRKVMEITAEWLWRTLGRNKRPRLCTREEFTKKVRTNADSAKAAVEDEEFWKLVDRERELHKLGKCGSCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGVRYLEFEALGFLNEDHWFSRENSYSGVEGEGLHKLGYILRDISKIPGGAMYADDTAGWDTRITEDDLHNEEKIIQQMDPEHRQLANAIFKLTYQNKVVKVQRPTPTGTVMDIISRKDQRGSGQVGTYGLNTFTNMEAQLVRQMEGEGVLTKADLENPHLLEKKITQWLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGKVRKDIPQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIGRARISQGAGWSLRETACLGKAYAQMWSLMYFHRRDLRLASNAICSAVPVHWVPTSRTTWSIHAHHQWMTTEDMLTVWNRVWIEENPWMEDKTPVTTWENVPYLGKREDQWCGSLIGLTSRATWAQNIPTAIQQVRSLIGNEEFLDYM 6xli A 2.00 BS01 III E 1 F27 T28 S31 Y32 K53 W99 G100 D101 G103 W104 F20 T21 S24 Y25 K46 W92 G93 D94 G96 W97 32894244 GGDLVKPGGSLKLSCAASGFTFSSYAMSWVRQNPEKRLEWVASISKGGNTYYPNSVKGRFTISRDNARNILYLQMSSLRSEDTALYYCARGWGDYGWFAYWGQVTLVTVSAASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 6xli B 2.00 BS01 III E 1 Y32 Y91 D92 E93 F94 L96 Y32 Y91 D92 E93 F94 L96 32894244 DIKMTQSPSSMYASLGERVTITCKASQDINRYLNWFQQKPGKSPKTLIYRANRLLDGVPSRFSGSGSGQDYSLTISSLDYEDMGIYYCLQYDEFPLTFGDGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG 6xli C 2.00 BS01 III F 1 F27 T28 S31 Y32 K53 W99 G100 G103 W104 F25 T26 S29 Y30 K51 W97 G98 G101 W102 32894244 KLVESGGDLVKPGGSLKLSCAASGFTFSSYAMSWVRQNPEKRLEWVASISKGGNTYYPNSVKGRFTISRDNARNILYLQMSSLRSEDTALYYCARGWGDYGWFAYWGQVTLVTVSAASTKGPSVFPLAPSSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 6xli D 2.00 BS01 III F 1 Y32 Y91 D92 E93 F94 Y32 Y91 D92 E93 F94 32894244 DIKMTQSPSSMYASLGERVTITCKASQDINRYLNWFQQKPGKSPKTLIYRANRLLDGVPSRFSGSGSGQDYSLTISSLDYEDMGIYYCLQYDEFPLTFGDGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE 6xmq A 3.70 BS01 ACP A 1 D487 T489 F582 K587 K604 G605 R634 L636 T697 G698 D699 D816 N819 D474 T476 F569 K574 K591 G592 R621 L623 T677 G678 D679 D796 N799 7.2.2.- KSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFEWTFVYLGTLVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTTPNNGSDGIVEIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKCKGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWLLDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKKWVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTPLLKESIKLRPSEDNLQLDGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDGGALAIVTKTGFETSQGSLVRVMIYSAERVSVDNKEALMFILFLLIFAVIASWYVWVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSSLAALAKFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIRHLYSAAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERKNSNYREGTGKLDIIRRFQFSSALKRSASIASHNDALFAAVKGAPETIRERLSDIPKNYDEIYKSFTRSGSRVLALASKSLPKDLNRDDVESELTFNGFLIFHCPLKDDAIETIKMLNESSHRSIMITGDNPLTAVHVAKEVGIVFGETLILDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDIAVTGYALNALEGHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTNDVGALKQAHVGIALLNGTEEGLKKLGEQRRLEASCAAPFTSKLANVSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDGQATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHIATLVYITTEIYKLEPREPQVDLEKEFAPSLLNTGIFIIQLVQQVSTFAVNYQGEPFRENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVPMTDDFKIKLTLTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVK 6xmq A 3.70 BS02 MG A 1 D487 T489 D816 D474 T476 D796 7.2.2.- KSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFEWTFVYLGTLVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTTPNNGSDGIVEIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKCKGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWLLDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKKWVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTPLLKESIKLRPSEDNLQLDGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDGGALAIVTKTGFETSQGSLVRVMIYSAERVSVDNKEALMFILFLLIFAVIASWYVWVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSSLAALAKFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIRHLYSAAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERKNSNYREGTGKLDIIRRFQFSSALKRSASIASHNDALFAAVKGAPETIRERLSDIPKNYDEIYKSFTRSGSRVLALASKSLPKDLNRDDVESELTFNGFLIFHCPLKDDAIETIKMLNESSHRSIMITGDNPLTAVHVAKEVGIVFGETLILDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDIAVTGYALNALEGHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTNDVGALKQAHVGIALLNGTEEGLKKLGEQRRLEASCAAPFTSKLANVSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDGQATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHIATLVYITTEIYKLEPREPQVDLEKEFAPSLLNTGIFIIQLVQQVSTFAVNYQGEPFRENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVPMTDDFKIKLTLTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVK 6xms A 3.40 BS02 ALF A 1 D487 T489 T697 G698 K797 D474 T476 T677 G678 K777 7.2.2.- KSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFEWTFVYLGTLVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTTPNNGSDGIVEIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKCKGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWLLDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKKWVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTPLLKESIKLRPSEDNLQLDGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDGGALAIVTKTGFETSQGSLVRVMIYSAERVSVDNKEALMFILFLLIFAVIASWYVWVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSSLAALAKFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIRHLYSAAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERKNSNYREGTGKLDIIRRFQFSSALKRSASIASHNDALFAAVKGAPETIRERLSDIPKNYDEIYKSFTRSGSRVLALASKSLPKDLNRDDVESELTFNGFLIFHCPLKDDAIETIKMLNESSHRSIMITGDNPLTAVHVAKEVGIVFGETLILDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDIAVTGYALNALEGHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTNDVGALKQAHVGIALLNGTEEGLKKLGEQRRLEALKLGDASCAAPFTSKLANVSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDGQATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHIATLVYITTEIYKLEPREPQVDLEKEFAPSLLNTGIFIIQLVQQVSTFAVNYQGEPFRENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVPMTDDFKIKLTLTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVK 6xmt A 3.30 BS01 BEF A 1 G309 D487 K488 T489 K797 N819 G296 D470 K471 T472 K773 N795 7.2.2.- KSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFEWTFVYLGTLVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTTPNNGSDGIVEIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKCKGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWLLDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKKWVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTPLLKESIKLRPSEDNLQLDGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDGGALAIVTKTGFETSQGSLVRVMIYSAEDNKEALMFILFLLIFAVIASWYVWVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSSLAALAKFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIRHLYSAAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERKNSNYREGTGKLDIIRRFQFSSALKRSASIASHNDALFAAVKGAPETIRERLSDIPKNYDEIYKSFTRSGSRVLALASKSLPKDLNRDDVESELTFNGFLIFHCPLKDDAIETIKMLNESSHRSIMITGDNPLTAVHVAKEVGIVFGETLILDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDIAVTGYALNALEGHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTNDVGALKQAHVGIALLNGTEEGLKKLGEQRRLEGMKAPALKLGDASCAAPFTSKLANVSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDGQATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHIATLVYITTEIYKLEPREPQVDLEKEFAPSLLNTGIFIIQLVQQVSTFAVNYQGEPFRENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVPMTDDFKIKLTLTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVK 6xmt A 3.30 BS02 MG A 1 D487 T489 D816 G817 D470 T472 D792 G793 7.2.2.- KSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFEWTFVYLGTLVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTTPNNGSDGIVEIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKCKGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWLLDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKKWVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTPLLKESIKLRPSEDNLQLDGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDGGALAIVTKTGFETSQGSLVRVMIYSAEDNKEALMFILFLLIFAVIASWYVWVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSSLAALAKFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIRHLYSAAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERKNSNYREGTGKLDIIRRFQFSSALKRSASIASHNDALFAAVKGAPETIRERLSDIPKNYDEIYKSFTRSGSRVLALASKSLPKDLNRDDVESELTFNGFLIFHCPLKDDAIETIKMLNESSHRSIMITGDNPLTAVHVAKEVGIVFGETLILDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDIAVTGYALNALEGHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTNDVGALKQAHVGIALLNGTEEGLKKLGEQRRLEGMKAPALKLGDASCAAPFTSKLANVSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDGQATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHIATLVYITTEIYKLEPREPQVDLEKEFAPSLLNTGIFIIQLVQQVSTFAVNYQGEPFRENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVPMTDDFKIKLTLTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVK 6xmu A 3.30 BS01 III B 1 M227 M231 P445 E446 M449 M453 M214 M218 P428 E429 M432 M436 7.2.2.- KSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFEWTFVYLGTLVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTTPNNGSDGIVEIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKCKGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWLLDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKKWVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTPLLKESIKLRPSEDNLQLDGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDGGALAIVTKTGFETSQGSLVRVMIYSAEDNKEALMFILFLLIFAVIASWYVWVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSSLAALAKFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIRHLYSAAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERKNSNYREGTGKLDIIRRFQFSSALKRSASIASHNDALFAAVKGAPETIRERLSDIPKNYDEIYKSFTRSGSRVLALASKSLPKDLNRDDVESELTFNGFLIFHCPLKDDAIETIKMLNESSHRSIMITGDNPLTAVHVAKEVGIVFGETLILDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDIAVTGYALNALEGHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTNDVGALKQAHVGIALLNGTEEGLKKLGEQRRLEGAPALKLGDASCAAPFTSKLANVSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDGQATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHIATLVYITTEIYKLEPREPQVDLEKEFAPSLLNTGIFIIQLVQQVSTFAVNYQGEPFRENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVPMTDDFKIKLTLTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVK 6xmu A 3.30 BS02 BEF A 1 D487 K488 T489 T697 K797 N819 D470 K471 T472 T673 K773 N795 7.2.2.- KSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFEWTFVYLGTLVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTTPNNGSDGIVEIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKCKGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWLLDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKKWVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTPLLKESIKLRPSEDNLQLDGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDGGALAIVTKTGFETSQGSLVRVMIYSAEDNKEALMFILFLLIFAVIASWYVWVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSSLAALAKFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIRHLYSAAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERKNSNYREGTGKLDIIRRFQFSSALKRSASIASHNDALFAAVKGAPETIRERLSDIPKNYDEIYKSFTRSGSRVLALASKSLPKDLNRDDVESELTFNGFLIFHCPLKDDAIETIKMLNESSHRSIMITGDNPLTAVHVAKEVGIVFGETLILDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDIAVTGYALNALEGHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTNDVGALKQAHVGIALLNGTEEGLKKLGEQRRLEGAPALKLGDASCAAPFTSKLANVSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDGQATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHIATLVYITTEIYKLEPREPQVDLEKEFAPSLLNTGIFIIQLVQQVSTFAVNYQGEPFRENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVPMTDDFKIKLTLTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVK 6xp9 A 2.27 BS01 QCG A 1 V211 L213 Y225 L239 M243 M246 Q285 F288 W299 C301 Y306 M323 V46 L48 Y60 L67 M71 M74 Q113 F116 W127 C129 Y134 M143 2.3.1.48 32890685 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVWSQVRKDLKVSLQLRGEDGSVWNYKPPIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGISLTERHKILHRLLQE 6xp9 B 2.27 BS01 QCG B 1 V211 L213 Y225 L239 H242 M243 M246 Q285 F288 W299 C301 Y306 M323 H327 V38 L40 Y52 L59 H62 M63 M66 Q105 F108 W119 C121 Y126 M138 H142 2.3.1.48 32890685 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVKVSLQLRGEDGSVWNYKPPIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITSLTERHKILHRLLQEGSP 6xr5 A 1.70 BS01 ADE A 1 L63 L76 S109 G125 L126 L64 L77 S110 G123 L124 4.1.1.33 HMVHEATASAPVNIACIKYWGKRDTRLILPTNSSLSVTLDQDHLRSTTTSRADASFEAGDRLWLNGREEAIKEGGRLAVCIKELRAWRKEMETKDKNLPKLSEWPLRIASYNNFAGLASSASGLAALVASLASLYSLPQSPSQLSLVARQGSGSACRSLFGGFVAWREGTDPAGSDSLAEEVAPREHWPEMHALICVVSDAKKGTSTSGMQKTVETSTLLQERLRVVPKRMDAISQAIKARDFAEFAKLTMADSNSFHAVCLDTAPPIFYLNDVSRAIIAVVEELNRAAGEIIAAYTFDAGPNAVIYTLEKNMPFVLGAIKRFFPTSEEFESPFQTGVRDLPEGFNTGVVREGGWEKGAVKGLIHTRVGDGPRVLEKEDSLLGENGVPKVLA 6xr5 B 1.70 BS01 ADE B 1 L63 S109 N111 S121 G125 L64 S110 N112 S121 G125 4.1.1.33 HMVHEATASAPVNIACIKYWGKRDTRLILPTNSSLSVTLDQDHLRSTTTSRADASFEAGDRLWLNGREEAIKEGGRLAVCIKELRAWRKEMETKDKNLPKLSEWPLRIASYNNFPAAGLASSASGLAALVASLASLYSLPQSPSQLSLVARQGSGSACRSLFGGFVAWREGTDPAGSDSLAEEVAPREHWPEMHALICVVSDASSTSGMQKTVETSTLLQERLRVVPKRMDAISQAIKARDFAEFAKLTMADSNSFHAVCLDTAPPIFYLNDVSRAIIAVVEELNRAAGEIIAAYTFDAGPNAVIYTLEKNMPFVLGAIKRFFPTSEEFESPFQTGVRDLPEGFNTGVVREGGWEKGAVKGLIHTRVGDGPRVLEKEDSLLGENGVPKVLA 6xr5 E 1.70 BS01 ADE E 1 L63 S109 S121 S122 G125 L63 S109 S121 S122 G125 4.1.1.33 MVHEATASAPVNIACIKYWGKRDTRLILPTNSSLSVTLDQDHLRSTTTSRADASFEAGDRLWLNGREEAIKEGGRLAVCIKELRAWRKEMETKDKNLPKLSEWPLRIASYNNFPTAAGLASSASGLAALVASLASLYSLPQSPSQLSLVARQGSGSACRSLFGGFVAWREGTDPAGSDSLAEEVAPREHWPEMHALICVVSDASSTSGMQKTVETSTLLQERLRVVPKRMDAISQAIKARDFAEFAKLTMADSNSFHAVCLDTAPPIFYLNDVSRAIIAVVEELNRAAGEIIAAYTFDAGPNAVIYTLEKNMPFVLGAIKRFFPTSEEFTGVRDLPEGFNTGVVREGGWEKGAVKGLIHTRVGDGPRVLEKEDSLLGENGVPKVLA 6xr5 H 1.70 BS01 ADE H 1 L63 L76 S109 S121 S122 G125 L126 L64 L77 S110 S119 S120 G123 L124 4.1.1.33 HMVHEATASAPVNIACIKYWGKRDTRLILPTNSSLSVTLDQDHLRSTTTSRADASFEAGDRLWLNGREEAIKEGGRLAVCIKELRAWRKEMETKDKNLPKLSEWPLRIASYNNFAGLASSASGLAALVASLASLYSLPQSPSQLSLVARQGSGSACRSLFGGFVAWREGTDPAGSDSLAEEVAPREHWPEMHALICVVSDAKKGTSTSGMQKTVETSTLLQERLRVVPKRMDAISQAIKARDFAEFAKLTMADSNSFHAVCLDTAPPIFYLNDVSRAIIAVVEELNRAAGEIIAAYTFDAGPNAVIYTLEKNMPFVLGAIKRFFPTSEEFESPFQTGVRDLPEGFNTGVVREGGWEKGAVKGLIHTRVGDGPRVLEKEDSLLGENGVPKVLA 6xrs A 2.80 BS01 GDP A 1 N200 V201 G202 K203 S204 T205 N309 K310 D312 S342 A343 L344 N169 V170 G171 K172 S173 T174 N254 K255 D257 S287 A288 L289 IMKPTIALIGRPNVGKSTLFNRLTRTKDALVHDLPGLTRDRHYGHGKVGSKPYFVIDTGGFEMAKQTLQAVDEADAVVFLVDGRTGLTPQDKIIADRLRQSPRPVYLAVNKGEDRAVLAAEFYELALGEPHVISGAHGDGVYYLIEEILENFPEADAKHPVFAVIGRPNVGKSTLVNAILGEKRVIASIHIDFEREGKPFTIIDKFSVIKAMQAVEAANVAVLVLDAQQDIADQDATIAGFALEAGRALVVAVNKWDGISEERREQVKRDISRKLYFLDFAKFHFISALKERGIDGLFESIQAAYNAAMIKMPTPKITRVLQTAVGRQQPPVRPKMRYAHQGGMNPPVIVVHGNSLHAISDSYTRYLTQTFRKAFNLQGTPLRIQYNV 6xrs A 2.80 BS02 GDP C 1 N27 G29 K30 N13 G15 K16 IMKPTIALIGRPNVGKSTLFNRLTRTKDALVHDLPGLTRDRHYGHGKVGSKPYFVIDTGGFEMAKQTLQAVDEADAVVFLVDGRTGLTPQDKIIADRLRQSPRPVYLAVNKGEDRAVLAAEFYELALGEPHVISGAHGDGVYYLIEEILENFPEADAKHPVFAVIGRPNVGKSTLVNAILGEKRVIASIHIDFEREGKPFTIIDKFSVIKAMQAVEAANVAVLVLDAQQDIADQDATIAGFALEAGRALVVAVNKWDGISEERREQVKRDISRKLYFLDFAKFHFISALKERGIDGLFESIQAAYNAAMIKMPTPKITRVLQTAVGRQQPPVRPKMRYAHQGGMNPPVIVVHGNSLHAISDSYTRYLTQTFRKAFNLQGTPLRIQYNV 6xrs B 2.80 BS02 GDP B 2 N27 G29 T32 K135 N13 G15 T18 K113 IMKPTIALIGRPNVGKSTLFNRLTRTKDALVHDLPGLTRDRHYGHGKVGSKPYFVIDTGGFEHEMAKQTLQAVDEADAVVFLVDGRTGLTPQDKIIADRLRQSPRPVYLAVNKGEGGDRAVLAAEFYELALGEPHVISGAHGDGVYYLIEEILENFPEADAKHPVFAVIGRPNVGKSTLVNAILGEKRVIAIHIDFEREGKPFTIIDTFSVIKAMQAVEAANVAVLVLDAQQDIADQDATIAGFALEAGRALVVAVNKWDGISEERREQVKRDISRKLYFLDFAKFHFISALKERGIDGLFESIQAAYNAAMIKMPTPKITRVLQTAVGRQQPPLVRPKMRYAHQGGMNPPVIVVHGNSLHAISDSYTRYLTQTFRKAFNLQGTPLRIQYNV 6xrs C 2.80 BS01 GDP C 1 N27 V28 G29 K30 S31 T32 K135 E137 S160 G161 A162 N12 V13 G14 K15 S16 T17 K105 E107 S130 G131 A132 MKPTIALIGRPNVGKSTLFNRLTRDLPGLTRDRHYGHGKVGSKPYFVIDTGGFEHEMAKQTLQAVDEADAVVFLVDGRTGLTPQDKIIADRLRQSPRPVYLAVNKGEGGDRAVLAAEFYELALGEPHVISGAHGDGVYYLIEEILENFPEADAKHPVFAVIGRPNVGKSTLVNAILGEKRVIAFIHIDFEREGKPFTIIDTFSVIKAMQAVEAANVAVLVLDAQQDIADQDATIAGFALEAGRALVVAVNKWDGISEERREQVKRDISRKLYFLDFAKFHFISALKERGIDGLFESIQAAYNAAMIKMPTPKITRVLQTAVGRQQPPRAGLVRPKMRYAHQGGMNPPVIVVHGNSLHAISDSYTRYLTQTFRKAFNLQGTPLRIQYNV 6xrs D 2.80 BS01 GDP B 3 N27 V28 G29 K30 S31 T32 R108 K135 A162 N13 V14 G15 K16 S17 T18 R81 K108 A135 IMKPTIALIGRPNVGKSTLFNRLTRTKDHDLPGLTRDRHYGHGKVGSKPYFVIDTGGFEMAKQTLQAVDEADAVVFLVDGRTGLTPQDKIIADRLRQSPRPVYLAVNKGEGGDRAVLAAEFYELALGEPHVISGAHGDGVYYLIEEILENFPEADAKHPVFAVIGRPNVGKSTLVNAILGEKRVIAFDIHIDFEREGKPFTIIDTFSVIKAMQAVEAANVAVLVLDAQQDIADQDATIAGFALEAGRALVVAVNKWDGISEERREQVKRDISRKLYFLDFAKFHFISALKERGIDGLFESIQAAYNAAMIKMPTPKITRVLQTAVGRQQPPRAGLVRPKMRYAHQGGMNPPVIVVHGNSLHAISDSYTRYLTQTFRKAFNLQGTPLRIQYNV 6xze A 1.54 BS02 O4Z A 1 H94 H96 H119 A135 V143 L198 T199 H200 Y204 W209 H91 H93 H116 A132 V140 L195 T196 H197 Y201 W206 4.2.1.1 32272689 DWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 6xze B 1.54 BS02 O4Z B 1 H67 F91 Q92 H94 H96 H119 L131 V143 L198 T199 H200 W209 H64 F88 Q89 H91 H93 H116 L128 V140 L195 T196 H197 W206 4.2.1.1 32272689 DWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 6xzo A 1.44 BS02 O55 A 1 F91 H94 H96 H119 A132 A135 V143 L198 T199 H200 Y204 W209 F88 H91 H93 H116 A129 A132 V140 L195 T196 H197 Y201 W206 4.2.1.1 32272689 DWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 6xzs B 1.53 BS02 O5K B 1 H67 Q92 H94 H96 H119 L131 L141 V143 L198 T199 H200 W209 H64 Q89 H91 H93 H116 L128 L138 V140 L195 T196 H197 W206 4.2.1.1 32272689 DWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 6xzx A 1.55 BS02 O5H A 1 H67 F91 Q92 H94 H96 H119 A121 A135 V143 L198 T199 H200 W209 H64 F88 Q89 H91 H93 H116 A118 A132 V140 L195 T196 H197 W206 4.2.1.1 32272689 DWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 6y00 A 1.37 BS02 O5T A 1 H94 H96 H119 L131 A135 L141 V143 L198 T199 H200 P201 P202 W209 H91 H93 H116 L128 A132 L138 V140 L195 T196 H197 P198 P199 W206 4.2.1.1 32272689 DWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 6y1n H 2.20 BS01 XOP L 1 Y35 Y52 F100 T102 Y34 Y51 F97 T99 32859757 VQLQESGPGLVKPSQTLSLTCTVSGGSISSGGYYWSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVTISVDTNQFSLKLSSVTAADTAVYYCARFGTRGNTHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVE 6y1n L 2.20 BS01 XOP L 1 Y33 W92 Y32 W91 32859757 SVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVDWYQQLPGTAPKLLIYRNNQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDDSLGTVFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 6y2z A 2.15 BS01 MG A 1 K85 D88 K90 D93 HHHHHMVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLEEMASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLG 6y32 A 2.60 BS01 GNP A 1 Q110 G111 S112 G113 K114 T115 T116 K120 R141 Q147 G193 K249 D251 G274 T275 G276 E277 Q88 G89 S90 G91 K92 T93 T94 K98 R119 Q125 G171 K227 D229 G252 T253 G254 E255 IINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLEEMASLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLG 6y32 A 2.60 BS02 GNP B 1 Q110 G111 R141 Q88 G89 R119 IINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLEEMASLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLG 6y32 B 2.60 BS01 GNP A 1 N427 R458 M525 N95 R126 M189 MGSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA 6y32 B 2.60 BS02 GNP B 1 N427 G428 V429 G430 K431 S432 T433 N434 K437 R458 Q464 G523 K589 D591 G615 T616 G617 Q618 N95 G96 V97 G98 K99 S100 T101 N102 K105 R126 Q132 G187 K253 D255 G279 T280 G281 Q282 MGSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA 6y32 C 2.60 BS02 MG C 1 T115 D190 T87 D162 IINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLG 6y32 E 2.60 BS02 MG E 1 T115 R141 Q147 T87 R113 Q119 IINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLG 6y32 F 2.60 BS03 MG F 1 S432 R458 D520 S98 R124 D186 MGSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA 6y32 G 2.60 BS02 MG G 1 T115 D138 R141 D190 T86 D109 R112 D161 IINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLG 6y5d A 4.10 BS02 NUC J 1 R41 Y42 P44 G45 V47 A48 R64 K65 L66 R70 R3 Y4 P6 G7 V9 A10 R26 K27 L28 R32 32911482 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLAAIHAKRVTIMPKDIQLARRIRGE 6y5d C 4.10 BS01 NUC I 1 R12 A13 K16 S17 R18 R21 G29 R33 R78 R1 A2 K5 S6 R7 R10 G18 R22 R67 32911482 RAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLP 6y5d D 4.10 BS01 NUC I 1 S33 G54 I55 S57 R87 S88 T89 S1 G22 I23 S25 R55 S56 T57 32911482 SRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 6y5d D 4.10 BS03 PTD H 1 Y84 K86 Y52 K54 32911482 SRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 6y5d E 4.10 BS01 NUC I 1 R41 Y42 P44 G45 V47 R50 K65 L66 R70 R3 Y4 P6 G7 V9 R12 K27 L28 R32 32911482 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLAAIHAKRVTIMPKDIQLARRIRGE 6y5d G 4.10 BS01 NUC I 1 R12 K14 R36 R43 V44 G45 A46 K76 T77 R1 K3 R25 R32 V33 G34 A35 K65 T66 32911482 RAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPK 6y5d G 4.10 BS02 NUC J 1 A13 A15 K16 R18 R21 G29 R30 R33 R43 R78 A2 A4 K5 R7 R10 G18 R19 R22 R32 R67 32911482 RAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPK 6y5d H 4.10 BS02 NUC J 1 S33 R34 Y43 G54 S56 S57 R87 S88 T89 S2 R3 Y12 G23 S25 S26 R56 S57 T58 32911482 RSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 6y5d K 4.10 BS01 NUC I 1 K347 K350 K187 K190 2.7.7.86 32911482 GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSETCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF 6y5d K 4.10 BS02 NUC V 1 R300 R499 R140 R339 2.7.7.86 32911482 GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSETCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF 6y5d M 4.10 BS02 NUC V 1 R41 Y42 P44 G45 T46 V47 A48 R64 L66 R3 Y4 P6 G7 T8 V9 A10 R26 L28 32911482 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLAAIHAKRVTIMPKDIQLARRIRGE 6y5d N 4.10 BS02 NUC V 1 R36 R40 K45 R46 I47 S48 G49 T81 R12 R16 K21 R22 I23 S24 G25 T57 32911482 DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6y5d Q 4.10 BS01 NUC U 1 R41 Y42 G45 V47 A48 K65 L66 R70 K116 R1 Y2 G5 V7 A8 K25 L26 R30 K76 32911482 RYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLAAIHAKRVTIMPKDIQLARRIRGE 6y5d Q 4.10 BS02 NUC V 1 R41 Y42 R43 P44 T46 R64 R73 R84 F85 R117 V118 T119 M121 K123 R1 Y2 R3 P4 T6 R24 R33 R44 F45 R77 V78 T79 M81 K83 32911482 RYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLAAIHAKRVTIMPKDIQLARRIRGE 6y5d R 4.10 BS01 NUC U 1 R46 I47 G49 K80 R22 I23 G25 K56 32911482 DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGF 6y5d S 4.10 BS01 NUC U 1 R30 R43 V44 G45 A46 T77 R19 R32 V33 G34 A35 T66 32911482 RAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQ 6y5d S 4.10 BS02 NUC V 1 R12 A13 K14 A15 K16 S17 R18 R21 R43 R1 A2 K3 A4 K5 S6 R7 R10 R32 32911482 RAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQ 6y5e C 3.15 BS01 NUC I 1 R12 A13 K16 S17 R18 R21 G29 R33 R43 R78 R1 A2 K5 S6 R7 R10 G18 R22 R32 R67 32911482 RAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLP 6y5e F 3.15 BS02 NUC J 1 K21 P33 R37 K1 P13 R17 32911482 KVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 6y5e G 3.15 BS03 PTD D 1 L34 K37 L23 K26 32911482 RAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPK 6y5e H 3.15 BS01 NUC I 1 R32 S33 R34 K35 Y41 R1 S2 R3 K4 Y10 32911482 RSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 6y88 A 2.10 BS01 137 A 1 E61 K63 S66 P67 S68 F102 K123 E172 N194 R196 L198 E224 S225 G226 L245 V246 G247 E248 E59 K61 S64 P65 S66 F100 K121 E170 N192 R194 L196 E222 S223 G224 L243 V244 G245 E246 4.1.1.48 VPTVLQKILARKAEEVAERRARVNLAEVERLARSADAPRGFANALLERAKRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDVDFFQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALDDVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHTFEVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFMRADDPGLELKRLFFQ 6y88 A 2.10 BS02 GOL A 1 D38 A39 R41 R113 D36 A37 R39 R111 4.1.1.48 VPTVLQKILARKAEEVAERRARVNLAEVERLARSADAPRGFANALLERAKRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDVDFFQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALDDVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHTFEVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFMRADDPGLELKRLFFQ 6y88 B 2.10 BS01 137 B 1 E61 K63 S66 P67 S68 L96 F102 K123 R196 L198 E224 S225 G226 L245 V246 G247 E248 E60 K62 S65 P66 S67 L95 F101 K122 R195 L197 E223 S224 G225 L244 V245 G246 E247 4.1.1.48 SVPTVLQKILARKAEEVAERRARVNLAEVERLARSADAPRGFANALLERAKRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDVDFFQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALDDVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHTFEVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFMRADDPGLELKRLFFQ 6y88 B 2.10 BS02 GOL B 1 S66 P67 G70 D100 F101 S65 P66 G69 D99 F100 4.1.1.48 SVPTVLQKILARKAEEVAERRARVNLAEVERLARSADAPRGFANALLERAKRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDVDFFQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALDDVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHTFEVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFMRADDPGLELKRLFFQ 6y88 B 2.10 BS03 GOL B 2 D106 K110 I138 D105 K109 I137 4.1.1.48 SVPTVLQKILARKAEEVAERRARVNLAEVERLARSADAPRGFANALLERAKRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDVDFFQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALDDVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHTFEVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFMRADDPGLELKRLFFQ 6y88 C 2.10 BS02 GOL C 1 K14 R21 T97 R122 D124 Q131 E134 K13 R20 T96 R121 D123 Q130 E133 4.1.1.48 SVPTVLQKILARKAEEVAERRARVNLAEVERLARSADAPRGFANALLERAKRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDVDFFQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALDDVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHTFEVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFMRADDPGLELKRLFF 6y88 D 2.10 BS01 137 D 1 V6 E61 K63 P67 S68 F102 K123 E172 N194 R196 L198 F201 E224 S225 G226 L245 V246 G247 E248 V3 E58 K60 P64 S65 F99 K120 E169 N191 R193 L195 F198 E221 S222 G223 L242 V243 G244 E245 4.1.1.48 PTVLQKILARKAEEVAERRARVNLAEVERLARSADAPRGFANALLERAKRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDVDFFQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALDDVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHTFEVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFMRADDPGLELKRLFFQER 6y88 E 2.10 BS02 GOL E 1 R73 H75 F76 V77 E80 I81 R72 H74 F75 V76 E79 I80 4.1.1.48 SVPTVLQKILARKAEEVAERRARVNLAEVERLARSADAPRGFANALLERAKRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDVDFFQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALDDVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHTFEVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFMRADDPGLELKRLFFQ 6y88 G 2.10 BS01 PO4 G 1 K63 R196 S225 V246 G247 E248 K53 R182 S211 V232 G233 E234 4.1.1.48,4.1.1.48 GGGGGGGGGGGGGGVNLAEVERLARSADAPRGFANALLERAKRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALDDVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHTFEVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFMRADDPGLELKRLFFQE 6y88 H 2.10 BS02 GOL H 1 K14 E17 R21 T97 R122 D124 Q131 E134 K13 E16 R20 T96 R121 D123 Q130 E133 4.1.1.48 SVPTVLQKILARKAEEVAERRARVNLAEVERLARSADAPRGFANALLERAKRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDVDFFQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALDDVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHTFEVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFMRADDPGLELKRLFF 6yky A 2.52 BS01 OWQ A 1 L26 C28 V34 A47 E109 M111 E112 T113 D114 F159 L9 C11 V17 A30 E80 M82 E83 T84 D85 F130 2.7.11.24 32927028 SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIY 6yky B 2.52 BS01 OWQ B 1 L26 G27 C28 G29 V34 A47 E109 Y110 M111 E112 T113 N117 F159 L11 G12 C13 G14 V19 A32 E88 Y89 M90 E91 T92 N96 F138 2.7.11.24 32927028 LGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYSF 6yky C 2.52 BS01 OWQ C 1 L26 G30 V34 A47 Q108 E109 Y110 M111 T113 F159 D171 L14 G18 V22 A35 Q84 E85 Y86 M87 T89 F135 D147 2.7.11.24 32927028 GFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIY 6yky D 2.52 BS01 OWQ D 1 L26 G30 N31 V34 A47 Q108 E109 Y110 M111 T113 D114 F159 F172 L13 G17 N18 V21 A34 Q95 E96 Y97 M98 T100 D101 F146 F159 2.7.11.24 32927028 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYSF 6ylc A 2.43 BS01 OXW A 1 L26 G27 C28 V34 A47 Q108 E109 M111 E112 T113 D114 F159 L12 G13 C14 V20 A33 Q79 E80 M82 E83 T84 D85 F130 2.7.11.24 32927028 DLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYS 6ylc B 2.43 BS01 OXW B 1 L26 G27 C28 V34 A47 E109 Y110 M111 E112 F159 D171 L11 G12 C13 V19 A32 E86 Y87 M88 E89 F136 D148 2.7.11.24 32927028 LGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTLNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYSF 6ylc C 2.43 BS01 OXW C 1 L26 N31 V34 A47 K49 Q108 E109 M111 E112 T113 D114 F159 D171 L13 N18 V21 A34 K36 Q87 E88 M90 E91 T92 D93 F138 D150 2.7.11.24 32927028 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIY 6ylc D 2.43 BS01 OXW D 1 N31 V34 A47 K49 E109 Y110 M111 E112 F159 F172 N19 V22 A35 K37 E97 Y98 M99 E100 F147 F160 2.7.11.24 32927028 GFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYSF 6yll A 2.89 BS01 OYB A 1 L26 V34 A47 E109 Y110 M111 E112 T113 F159 L13 V19 A32 E89 Y90 M91 E92 T93 F139 2.7.11.24 32927028 FDLGSRYMDLKPLGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYSF 6yow A 1.23 BS01 III P 1 E14 V46 K49 N50 R56 R129 Y130 L174 N175 V178 E182 N226 L229 W230 E19 V51 K54 N55 R61 R130 Y131 L175 N176 V179 E183 N227 L230 W231 32816380 GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6yow A 1.23 BS02 L3Y A 1 K122 P167 I168 G171 I219 K123 P168 I169 G172 I220 32816380 GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6yox A 2.05 BS01 III P 1 E14 V46 N50 R56 R129 Y130 G171 L174 N175 V178 E182 L222 N226 L229 W230 E19 V51 N55 R61 R134 Y135 G176 L179 N180 V183 E187 L227 N231 L234 W235 32816380 GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6yox A 2.05 BS02 L3V A 1 K122 P167 I219 K127 P172 I224 32816380 GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6yoy A 1.80 BS01 III P 1 E14 V46 K49 N50 G53 G54 R56 K122 R129 Y130 G171 L174 N175 V178 E182 I219 L222 N226 L229 W230 E18 V50 K53 N54 G57 G58 R60 K121 R128 Y129 G170 L173 N174 V177 E181 I218 L221 N225 L228 W229 32816380 AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6yoy A 1.80 BS02 L3S A 1 K122 P167 G171 I219 K121 P166 G170 I218 32816380 AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6yp2 A 1.80 BS01 III P 1 E14 V46 K49 N50 R56 K122 R129 Y130 G171 L174 N175 V178 E182 L222 N226 L229 W230 E19 V51 K54 N55 R61 K127 R134 Y135 G176 L179 N180 V183 E187 L227 N231 L234 W235 32816380 GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6yp3 A 1.80 BS01 III P 1 E14 V46 K49 N50 G53 R56 R129 Y130 G171 L174 N175 V178 E182 L222 N226 L229 W230 E19 V51 K54 N55 G58 R61 R134 Y135 G176 L179 N180 V183 E187 L227 N231 L234 W235 32816380 GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6ypl A 1.80 BS02 P6H A 1 N42 S45 F119 K122 P167 G171 I219 N46 S49 F123 K126 P171 G175 I223 32816380 AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6ypy A 1.40 BS01 III P 1 E14 N42 V46 K49 N50 R56 R129 Y130 G171 L174 N175 V178 E182 N226 L229 W230 E17 N45 V49 K52 N53 R59 R132 Y133 G174 L177 N178 V181 E185 N229 L232 W233 32816380 MGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6ypy A 1.40 BS02 P7E A 1 C38 N42 F119 K122 P167 I168 C41 N45 F122 K125 P170 I171 32816380 MGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6yq2 A 1.40 BS01 III P 1 E14 L43 V46 R56 R129 Y130 G171 L174 N175 V178 E182 N226 L229 W230 E19 L48 V51 R61 R128 Y129 G170 L173 N174 V177 E181 N225 L228 W229 32816380 GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6yq2 A 1.40 BS02 P7T A 1 K122 P167 I168 L218 I219 L222 K121 P166 I167 L217 I218 L221 32816380 GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT 6yxa A 3.95 BS01 MN A 1 H53 H77 D78 D144 H52 H76 D77 D143 2.7.6.5 ANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYRKSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLVDGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQRRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYVDEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHEIAEYGVAAHWEGATFEKKLSWFREILEFQNESTDAEEFMESLDLFSDMVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVEILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFELKDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVAN 6z1d A 2.71 BS01 GD A 1 R38 E179 K185 P211 R37 E178 K184 P210 SYYIAPRFLDKLAVHITKNFLNIPGVRVPLILGIHGRKGEGKTFQCELAFEKMGIEVTLISGGELESPDAGDPARLIRLRYRETAELIKVRGKMCVLMINDLDAGAGRFDEGTQYTVNTQLVNATLMNIADNPTDVQLPGSYDSNPIRRVPIIVTGNDFSTLYAPLIRDGRMEKFYWEPNRDDKVGIVGGIFAEDGLSQREIEQLVDTFPKQSIDFFSALRSRIYDIQIRDFIHKVGFERISLRVVNSLEAPPEFKKPDFSLAHLIESGNLVLG 6z1d B 2.71 BS01 ADP B 1 Y3 Y4 G40 E41 G42 K43 T44 F45 Q46 L49 I188 I192 I215 D216 S219 Y2 Y3 G39 E40 G41 K42 T43 F44 Q45 L48 I176 I180 I203 D204 S207 SYYIAPRFLDKLAVHITKNFLNIPGVRVPLILGIHGRKGEGKTFQCELAFEKMGIEVTLISGGELESPDAGDPARLIRLRYRETAELIKVRGKMCVLMINDLDYTVNTQLVNATLMNIADNPTDVQLPGSYDSNPIRRVPIIVTGNDFSTLYAPLIRDGRMEKFYWEPNRDDKVGIVGGIFAEDGLSQREIEQLVDTFPKQSIDFFSALRSRIYDIQIRDFIHKVGFERISLRVVEFKKPDFSLAHLIESGNLVLGEQQ 6z1f 1 2.86 BS01 ADP 1 1 Y3 Y4 G40 E41 G42 K43 T44 F45 Q46 I188 I192 I215 D216 Y2 Y3 G39 E40 G41 K42 T43 F44 Q45 I187 I191 I214 D215 SYYIAPRFLDKLAVHITKNFLNIPGVRVPLILGIHGRKGEGKTFQCELAFEKMGIEVTLISGGELESPDAGDPARLIRLRYRETAELIKVRGKMCVLMINDLDAGAGRFDEGTQYTVNTQLVNATLMNIADNPTDVQLPGSYDSNPIRRVPIIVTGNDFSTLYAPLIRDGRMEKFYWEPNRDDKVGIVGGIFAEDGLSQREIEQLVDTFPKQSIDFFSALRSRIYDIQIRDFIHKVGFERISLRVVNSLEAPPEFKKPDFSLAHLIESGNLVLGEQQRVD 6z1f 2 2.86 BS01 AGS 2 1 Y3 Y4 K39 G40 E41 G42 K43 T44 F45 I188 I192 I215 D216 Y2 Y3 K38 G39 E40 G41 K42 T43 F44 I187 I191 I214 D215 SYYIAPRFLDKLAVHITKNFLNIPGVRVPLILGIHGRKGEGKTFQCELAFEKMGIEVTLISGGELESPDAGDPARLIRLRYRETAELIKVRGKMCVLMINDLDAGAGRFDEGTQYTVNTQLVNATLMNIADNPTDVQLPGSYDSNPIRRVPIIVTGNDFSTLYAPLIRDGRMEKFYWEPNRDDKVGIVGGIFAEDGLSQREIEQLVDTFPKQSIDFFSALRSRIYDIQIRDFIHKVGFERISLRVVNSLEAPPEFKKPDFSLAHLIESGNLVLGEQQRVDN 6z1f 3 2.86 BS01 AGS 2 1 P166 R169 R172 P165 R168 R171 SYYIAPRFLDKLAVHITKNFLNIPGVRVPLILGIHGRKGEGKTFQCELAFEKMGIEVTLISGGELESPDAGDPARLIRLRYRETAELIKVRGKMCVLMINDLDAGAGRFDEGTQYTVNTQLVNATLMNIADNPTDVQLPGSYDSNPIRRVPIIVTGNDFSTLYAPLIRDGRMEKFYWEPNRDDKVGIVGGIFAEDGLSQREIEQLVDTFPKQSIDFFSALRSRIYDIQIRDFIHKVGFERISLRVVNSLEAPPEFKKPDFSLAHLIESGNLVLGEQQRVDNSQL 6z1f 3 2.86 BS03 MG 3 1 T44 N101 T43 N100 SYYIAPRFLDKLAVHITKNFLNIPGVRVPLILGIHGRKGEGKTFQCELAFEKMGIEVTLISGGELESPDAGDPARLIRLRYRETAELIKVRGKMCVLMINDLDAGAGRFDEGTQYTVNTQLVNATLMNIADNPTDVQLPGSYDSNPIRRVPIIVTGNDFSTLYAPLIRDGRMEKFYWEPNRDDKVGIVGGIFAEDGLSQREIEQLVDTFPKQSIDFFSALRSRIYDIQIRDFIHKVGFERISLRVVNSLEAPPEFKKPDFSLAHLIESGNLVLGEQQRVDNSQL 6z1f 4 2.86 BS01 AGS 3 1 R28 P166 R169 R172 R27 P165 R168 R171 SYYIAPRFLDKLAVHITKNFLNIPGVRVPLILGIHGRKGEGKTFQCELAFEKMGIEVTLISGGELESPDAGDPARLIRLRYRETAELIKVRGKMCVLMINDLDAGAGRFDEGTQYTVNTQLVNATLMNIADNPTDVQLPGSYDSNPIRRVPIIVTGNDFSTLYAPLIRDGRMEKFYWEPNRDDKVGIVGGIFAEDGLSQREIEQLVDTFPKQSIDFFSALRSRIYDIQIRDFIHKVGFERISLRVVNSLEAPPEFKKPDFSLAHLIESGNLVLGEQQRVDN 6z1f 5 2.86 BS01 AGS 4 1 R28 R169 R172 R27 R168 R171 SYYIAPRFLDKLAVHITKNFLNIPGVRVPLILGIHGRKGEGKTFQCELAFEKMGIEVTLISGGELESPDAGDPARLIRLRYRETAELIKVRGKMCVLMINDLDAGAGRFDEGTQYTVNTQLVNATLMNIADNPTDVQLPGSYDSNPIRRVPIIVTGNDFSTLYAPLIRDGRMEKFYWEPNRDDKVGIVGGIFAEDGLSQREIEQLVDTFPKQSIDFFSALRSRIYDIQIRDFIHKVGFERISLRVVNSLEAPPEFKKPDFSLAHLIESGNLVLGEQQRVD 6z1f 5 2.86 BS02 AGS 5 1 Y3 Y4 R38 K39 G40 E41 G42 K43 T44 F45 Q46 I188 I192 I215 D216 S219 Y2 Y3 R37 K38 G39 E40 G41 K42 T43 F44 Q45 I187 I191 I214 D215 S218 SYYIAPRFLDKLAVHITKNFLNIPGVRVPLILGIHGRKGEGKTFQCELAFEKMGIEVTLISGGELESPDAGDPARLIRLRYRETAELIKVRGKMCVLMINDLDAGAGRFDEGTQYTVNTQLVNATLMNIADNPTDVQLPGSYDSNPIRRVPIIVTGNDFSTLYAPLIRDGRMEKFYWEPNRDDKVGIVGGIFAEDGLSQREIEQLVDTFPKQSIDFFSALRSRIYDIQIRDFIHKVGFERISLRVVNSLEAPPEFKKPDFSLAHLIESGNLVLGEQQRVD 6z1f 6 2.86 BS02 AGS 6 1 Y3 K39 G40 E41 G42 K43 T44 F45 Q46 D102 T156 N158 I188 I192 I215 D216 S219 Y2 K38 G39 E40 G41 K42 T43 F44 Q45 D101 T155 N157 I187 I191 I214 D215 S218 SYYIAPRFLDKLAVHITKNFLNIPGVRVPLILGIHGRKGEGKTFQCELAFEKMGIEVTLISGGELESPDAGDPARLIRLRYRETAELIKVRGKMCVLMINDLDAGAGRFDEGTQYTVNTQLVNATLMNIADNPTDVQLPGSYDSNPIRRVPIIVTGNDFSTLYAPLIRDGRMEKFYWEPNRDDKVGIVGGIFAEDGLSQREIEQLVDTFPKQSIDFFSALRSRIYDIQIRDFIHKVGFERISLRVVNPPEFKKPDFSLAHLIESGNLVLGEQQRVD 6z1f A 2.86 BS01 MG A 1 K202 D204 E205 K192 D194 E195 4.1.1.39 SYAQTKTQTKSGYTYYTPDYTPKDTDILAAFRVTPQPGVPFEEAAAAVAAESSTGTWTTVWTDLLTDLDRYKGRCYDIEPVPGEDNQFIAYIAYPLDLFEEGSITNVLTSIVGNVFGFKALRALRLEDIRFPVAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSAPFQRWRDRFLFVADAITKAQAETGEIKGHYLNVTAPTCEEMLKRAEYAKELKQPIIMHDYLTAGFTANTTLARWCRDNGVLLHIHRAMHAVIDRQKNHGIHFRVLAKALRLSGGDHIHTGTVVGKLEGERGITMGFVDLLRENYVEQDKSRGIYFTQDWASLPGVMAVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRNLAREGNDVIREAAKWSPELAVACELWKEIKFEFEAMDTV 6z1f A 2.86 BS02 CAP A 1 K176 K178 K202 E205 H295 R296 H328 K335 L336 S380 G381 G382 G404 G405 K166 K168 K192 E195 H285 R286 H318 K325 L326 S370 G371 G372 G394 G395 4.1.1.39 SYAQTKTQTKSGYTYYTPDYTPKDTDILAAFRVTPQPGVPFEEAAAAVAAESSTGTWTTVWTDLLTDLDRYKGRCYDIEPVPGEDNQFIAYIAYPLDLFEEGSITNVLTSIVGNVFGFKALRALRLEDIRFPVAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSAPFQRWRDRFLFVADAITKAQAETGEIKGHYLNVTAPTCEEMLKRAEYAKELKQPIIMHDYLTAGFTANTTLARWCRDNGVLLHIHRAMHAVIDRQKNHGIHFRVLAKALRLSGGDHIHTGTVVGKLEGERGITMGFVDLLRENYVEQDKSRGIYFTQDWASLPGVMAVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRNLAREGNDVIREAAKWSPELAVACELWKEIKFEFEAMDTV 6z1f B 2.86 BS01 MG B 1 K202 E205 K190 E193 4.1.1.39 GYKAGVQDYRLTYYTPDYTPKDTDILAAFRVTPQPGVPFEEAAAAVAAESSTGTWTTVWTDLLTDLDRYKGRCYDIEPVPGEDNQFIAYIAYPLDLFEEGSITNVLTSIVGNVFGFKALRALRLEDIRFPVAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSAPFQRWRDRFLFVADAITKAQAETGEIKGHYLNVTAPTCEEMLKRAEYAKELKQPIIMHDYLTAGFTANTTLARWCRDNGVLLHIHRAMHAVIDRQKNHGIHFRVLAKALRLSGGDHIHTGTVVGKLEGERGITMGFVDLLRENYVEQDKSRGIYFTQDWASLPGVMAVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRNLAREGNDVIREAAKWSPELAVACELWKEIKFEFE 6z1f C 2.86 BS03 CAP D 1 E61 W67 N124 E49 W55 N112 4.1.1.39 GYKAGVQDYRLTYYTPDYTPKDTDILAAFRVTPQPGVPFEEAAAAVAAESSTGTWTTVWTDLLTDLDRYKGRCYDIEPVPGEDNQFIAYIAYPLDLFEEGSITNVLTSIVGNVFGFKALRALRLEDIRFPVAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSAPFQRWRDRFLFVADAITKAQAETGEIKGHYLNVTAPTCEEMLKRAEYAKELKQPIIMHDYLTAGFTANTTLARWCRDNGVLLHIHRAMHAVIDRQKNHGIHFRVLAKALRLSGGDHIHTGTVVGKLEGERGITMGFVDLLRENYVEQDKSRGIYFTQDWASLPGVMAVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRNLAREGNDVIREAAKWSPELAVACELWKEIKFEFEAMDTV 6z1f E 2.86 BS01 MG E 1 K176 K178 K202 D204 E205 K164 K166 K190 D192 E193 4.1.1.39 GYKAGVQDYRLTYYTPDYTPKDTDILAAFRVTPQPGVPFEEAAAAVAAESSTGTWTTVWTDLLTDLDRYKGRCYDIEPVPGEDNQFIAYIAYPLDLFEEGSITNVLTSIVGNVFGFKALRALRLEDIRFPVAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSAPFQRWRDRFLFVADAITKAQAETGEIKGHYLNVTAPTCEEMLKRAEYAKELKQPIIMHDYLTAGFTANTTLARWCRDNGVLLHIHRAMHAVIDRQKNHGIHFRVLAKALRLSGGDHIHTGTVVGKLEGERGITMGFVDLLRENYVEQDKSRGIYFTQDWASLPGVMAVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRNLAREGNDVIREAAKWSPELAVACELWKEIKFEFEAMDTV 6z1f E 2.86 BS03 CAP F 1 E61 W67 E49 W55 4.1.1.39 GYKAGVQDYRLTYYTPDYTPKDTDILAAFRVTPQPGVPFEEAAAAVAAESSTGTWTTVWTDLLTDLDRYKGRCYDIEPVPGEDNQFIAYIAYPLDLFEEGSITNVLTSIVGNVFGFKALRALRLEDIRFPVAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSAPFQRWRDRFLFVADAITKAQAETGEIKGHYLNVTAPTCEEMLKRAEYAKELKQPIIMHDYLTAGFTANTTLARWCRDNGVLLHIHRAMHAVIDRQKNHGIHFRVLAKALRLSGGDHIHTGTVVGKLEGERGITMGFVDLLRENYVEQDKSRGIYFTQDWASLPGVMAVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRNLAREGNDVIREAAKWSPELAVACELWKEIKFEFEAMDTV 6za9 6 3.76 BS01 S12 T 1 I2 I9 I2 I9 DIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFA 6za9 T 3.76 BS01 S12 T 1 L70 K71 L69 K70 VPPVQVSPLIKLGRYSALFLGMAYGAKRYNYLKPRAEEERRLAAEEKKKRDEQKRIERELAEAQEDTILK 6zxv A 1.88 BS01 SFG A 1 M156 P183 M184 G186 D205 F206 I207 I210 G230 D231 A232 D248 Y249 P250 Y251 R253 L264 M160 P187 M188 G190 D209 F210 I211 I214 G234 D235 A236 D252 Y253 P254 Y255 R257 L268 GRGSMKFLFYLSADNLEIARKEVLVLAERYGWVEDYQFEERLLLLDYAGEKFFERLAYTNEVTKIYDICSVSELEQVFSEIPVYDRLCCVRVKGGKGKTALERKLGALLWKRGAKVSVSNPEIVYKVYIQDDKCYVGLLEFERDTRQFFLRRPDRRPFLMPSAIKPKLARALVNLTGVLEGETLLDPMCGTGSFLIEAGLMGINPIGIDFIEKIVRGCRVNLEYYGIEGSVLLGDAKNLPLRDESVRGIATDYPYLRSTKAAGTLDELYSKTSEEFERVLKKGGRAAIVTNIDVESFFSNFEIEMKTEERVHGSLTRRIYLLRRH 6zxw G 2.19 BS01 SFG G 1 P183 M184 G186 D205 F206 I210 G230 D231 A232 D248 Y249 P250 Y251 R253 L264 P183 M184 G186 D205 F206 I210 G230 D231 A232 D248 Y249 P250 Y251 R253 L264 MKFLFYLSADNLEIARKEVLVLAERYGWVEDYQFEERLLLLDYAGEKFFERLAYTNEVTKIYDICSVSELEQVFSEIPVYDRLCCVRVKGGKGKTALERKLGALLWKRGAKVSVSNPEIVYKVYIQDDKCYVGLLEFERDTRQFFLRRPDRRPFLMPSAIKPKLARALVNLTGVLEGETLLDPMCGTGSFLIEAGLMGINPIGIDFIEKIVRGCRVNLEYYGIEGSVLLGDAKNLPLRDESVRGIATDYPYLRSTKAAGTLDELYSKTSEEFERVLKKGGRAAIVTNIDVESFFSNFEIEMKTEERVHGSLTRRIYLLRRH 6zxw H 2.19 BS01 ZN H 1 C11 C14 C37 C40 C11 C14 C37 C40 MKRKLLEILACPLCKSELEVEVVEENEEEIISGKLVCSSCRAEFPIEDGIPDLRPPE 7a08 a 3.11 BS01 ZN a 1 C392 R394 W440 C245 R247 W293 2.7.7.86 32911480 DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL 7a08 b 3.11 BS01 NUC I 1 K13 A14 K15 S16 R17 R20 R29 R32 R77 K1 A2 K3 S4 R5 R8 R17 R20 R65 32911480 KAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLP 7a08 f 3.11 BS02 NUC J 1 A14 K15 R17 R20 R32 R77 A1 K2 R4 R7 R19 R64 32911480 AKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGG 7a08 g 3.11 BS01 NUC I 1 S36 V39 Y40 S2 V5 Y6 32911480 ESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSS 7a08 h 3.11 BS01 NUC I 1 R63 R72 R83 F84 Q85 S86 V117 T118 R7 R16 R27 F28 Q29 S30 V61 T62 32911480 STELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 7a08 h 3.11 BS02 NUC J 1 R63 K64 L65 P66 R69 R7 K8 L9 P10 R13 32911480 STELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 7a12 A 2.00 BS01 QVK A 1 F219 D262 H331 I338 H339 E364 H382 Y383 M384 A414 Y444 F110 D153 H222 I229 H230 E252 H270 Y271 M272 A302 Y332 3.4.11.18 32919012 KVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 7a13 A 2.04 BS01 QW5 A 1 F219 H231 D262 H331 I338 H339 E364 H382 Y383 M384 A414 Y444 F110 H122 D153 H222 I229 H230 E252 H270 Y271 M272 A302 Y332 3.4.11.18 32919012 KVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 7a14 A 2.14 BS01 QVB A 1 F219 P220 H231 D262 L328 H331 I338 H339 E364 H382 Y383 M384 A414 Y444 L447 F110 P111 H122 D153 L219 H222 I229 H230 E252 H270 Y271 M272 A302 Y332 L335 3.4.11.18 32919012 KVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 7a16 A 1.90 BS01 HZE A 1 F219 P220 H231 D262 L328 H331 I338 H339 E364 H382 A414 Y444 L447 F110 P111 H122 D153 L219 H222 I229 H230 E251 H269 A301 Y331 L334 3.4.11.18 32919012 KVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 7aap A 2.60 BS01 NUC P 1 D499 R513 L758 S759 D760 C813 S814 Q815 R836 A840 K849 R858 S861 L862 D865 D496 R510 L755 S756 D757 C810 S811 Q812 R833 A837 K846 R855 S858 L859 D862 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- AQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELNTSRYWEPEFYEAMYTPHT 7aap A 2.60 BS02 NUC T 1 K500 S501 N507 N543 V557 A558 R569 K577 A580 G590 S592 F594 Y595 S682 G683 D684 A685 Y689 E857 R914 M924 K497 S498 N504 N540 V554 A555 R566 K574 A577 G587 S589 F591 Y592 S679 G680 D681 A682 Y686 E854 R896 M906 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- AQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELNTSRYWEPEFYEAMYTPHT 7aap A 2.60 BS07 POP A 1 K50 N52 K73 R116 N209 Y217 D218 K47 N49 K70 R113 N206 Y214 D215 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- AQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELNTSRYWEPEFYEAMYTPHT 7aap A 2.60 BS08 GE6 T 1 K545 D623 S682 T687 N691 D760 S814 K542 D620 S679 T684 N688 D757 S811 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- AQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELNTSRYWEPEFYEAMYTPHT 7aap C 2.60 BS01 III D 1 D5 T9 V12 L13 V16 F49 M52 V53 L56 L60 V66 I68 D4 T8 V11 L12 V15 F48 M51 V52 L55 L59 V65 I67 3.4.19.12,3.4.22.-,3.4.22.69,2.7.7.48,3.6.4.12,3.6.4.13,3.1.13.- KMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDI 7bzb A 2.15 BS01 MG A 1 R447 N450 D451 E458 R427 N430 D431 E438 4.2.3.- SLWGDHFLSVSLDRGEFDELEREIETMKPLVKDMLMSSQSSDKEKIRLIHLLVSLGSSYHFDKEIQDILKHSFTKLDDIIVGEDDLETISIMFEVFRLYGHKMSCDAFDRFRGEDGRFKESLAKDVRGMLQLFEVAHLGTPSEDIMDEASSFAQNHLDSWIGGNVSGATPHLLKHIQNSLYIPRYCNIEVLVAREYISYYEQEEGHNKILLKFAKLNFNFCQFHYIQELKTLTKWWKDLDLASKLPYIRDRLVESHLGGLGPYFEPHYSLGRIIVAKIIMTMVVVDDTYDAHATVPEVAVLTECLQRLNIGADDKLPDYLRTVLESVFEVMGEIEQEMRPKGRSYGVKQVLERFKNVAKADKQLTEWARTGDVPSFDEYMKVGLVTAGMDGYAGYCFIGMEDVSEKEAFEWLSSNPLIIQALNVMFRLANDVGTYETEINRGEVANGLNCYMKQYGVTKEEASQELRKIYSNNKKVVMEEFMNSHDHVPRQVLLRCLNFARLFDVMYTEGDGYSEPKGKIEHFMTSLYVHPIPL 7bzb A 2.15 BS02 MG A 2 D306 Y309 E463 D286 Y289 E443 4.2.3.- SLWGDHFLSVSLDRGEFDELEREIETMKPLVKDMLMSSQSSDKEKIRLIHLLVSLGSSYHFDKEIQDILKHSFTKLDDIIVGEDDLETISIMFEVFRLYGHKMSCDAFDRFRGEDGRFKESLAKDVRGMLQLFEVAHLGTPSEDIMDEASSFAQNHLDSWIGGNVSGATPHLLKHIQNSLYIPRYCNIEVLVAREYISYYEQEEGHNKILLKFAKLNFNFCQFHYIQELKTLTKWWKDLDLASKLPYIRDRLVESHLGGLGPYFEPHYSLGRIIVAKIIMTMVVVDDTYDAHATVPEVAVLTECLQRLNIGADDKLPDYLRTVLESVFEVMGEIEQEMRPKGRSYGVKQVLERFKNVAKADKQLTEWARTGDVPSFDEYMKVGLVTAGMDGYAGYCFIGMEDVSEKEAFEWLSSNPLIIQALNVMFRLANDVGTYETEINRGEVANGLNCYMKQYGVTKEEASQELRKIYSNNKKVVMEEFMNSHDHVPRQVLLRCLNFARLFDVMYTEGDGYSEPKGKIEHFMTSLYVHPIPL 7bzc A 2.30 BS02 MG A 2 D306 Y309 D286 Y289 4.2.3.- SLWGDHFLSVSLDRGEFDELEREIETMKPLVKDMLMSSQSSDKEKIRLIHLLVSLGSSYHFDKEIQDILKHSFTKLDDIIVGEDDLETISIMFEVFRLYGHKMSCDAFDRFRGEDGRFKESLAKDVRGMLQLFEVAHLGTPSEDIMDEASSFAQNHLDSWIGGNVSGATPHLLKHIQNSLYIPRYCNIEVLVAREYISYYEQEEGHNKILLKFAKLNFNFCQFHYIQELKTLTKWWKDLDLASKLPYIRDRLVESHLGGLGPYFEPHYSLGRIIVAKIIMTMVVVDDTYDAHATVPEVAVLTECLQRLNIGADDKLPDYLRTVLESVFEVMGEIEQEMRPKGRSYGVKQVLERFKNVAKADKQLTEWARTGDVPSFDEYMKVGLVTAGMDGYAGYCFIGMEDVSEKEAFEWLSSNPLIIQALNVMFRLANDVGTYETEINRGEVANGLNCYMKQYGVTKEEASQELRKIYSNNKKVVMEEFMNSHDHVPRQVLLRCLNFARLFDVMYTEGDGYSEPKGKIEHFMTSLYVHPIPLS 7bzc A 2.30 BS03 FPS A 1 V303 D306 Y412 F446 R447 N450 M526 V283 D286 Y392 F426 R427 N430 M506 4.2.3.- SLWGDHFLSVSLDRGEFDELEREIETMKPLVKDMLMSSQSSDKEKIRLIHLLVSLGSSYHFDKEIQDILKHSFTKLDDIIVGEDDLETISIMFEVFRLYGHKMSCDAFDRFRGEDGRFKESLAKDVRGMLQLFEVAHLGTPSEDIMDEASSFAQNHLDSWIGGNVSGATPHLLKHIQNSLYIPRYCNIEVLVAREYISYYEQEEGHNKILLKFAKLNFNFCQFHYIQELKTLTKWWKDLDLASKLPYIRDRLVESHLGGLGPYFEPHYSLGRIIVAKIIMTMVVVDDTYDAHATVPEVAVLTECLQRLNIGADDKLPDYLRTVLESVFEVMGEIEQEMRPKGRSYGVKQVLERFKNVAKADKQLTEWARTGDVPSFDEYMKVGLVTAGMDGYAGYCFIGMEDVSEKEAFEWLSSNPLIIQALNVMFRLANDVGTYETEINRGEVANGLNCYMKQYGVTKEEASQELRKIYSNNKKVVMEEFMNSHDHVPRQVLLRCLNFARLFDVMYTEGDGYSEPKGKIEHFMTSLYVHPIPLS 7c3h A 1.70 BS02 LYS A 1 R68 D212 F216 Y369 W371 L441 A475 W476 R65 D209 F213 Y366 W368 L434 A468 W469 1.4.3.14 32894626 ELPPRKVCIVGAGVSGLYIAMILDDLKIPNLTYDIFESSSRTGGRLYTHHFTDAKHDYYDIGAMRYPDIPSMKRTFNLFKRTGMPLIKYYLDGENTPQLYNNHFFAKGVVDPYMVSVANGGTVPDDVVDSVGEKLQQAFGYYKEKLAEDFDKGFDELMLVDDMTTREYLKRGGPKGEAPKYDFFAIQWMETQNTGTNLFDQAFSESVIDSFDFDNPTKPEWYCIEGGTSLLVDAMKETLVHKVQNNKRVEAISIDLDAPDDGNMSVKIGGKDYSGYSTVFNTTALGCLDRMDLRGLNLHPTQADAIRCLHYDNSTKVALKFSYPWWIKDCGITCGGAASTDLPLRTCVYPSYNLGDTGEAVLLASYTWSQDATRIGSLVKDAPPEDELVELILQNLARLHAEHMTYEKIKEAYTGVYHAYCWANDPNVGGAFALFGPGQFSNLYPYLMRPAAGGKFHIVGEASSVHHAWIIGSLESAYTAVYQFLYKYKMWDYLRLLLERWQYGL 7c3h B 1.70 BS02 LYS B 1 R68 D212 F216 Y369 W371 F439 L441 A475 W476 R65 D209 F213 Y366 W368 F432 L434 A468 W469 1.4.3.14 32894626 ELPPRKVCIVGAGVSGLYIAMILDDLKIPNLTYDIFESSSRTGGRLYTHHFTDAKHDYYDIGAMRYPDIPSMKRTFNLFKRTGMPLIKYYLDGENTPQLYNNHFFAKGVVDPYMVSVANGGTVPDDVVDSVGEKLQQAFGYYKEKLAEDFDKGFDELMLVDDMTTREYLKRGGPKGEAPKYDFFAIQWMETQNTGTNLFDQAFSESVIDSFDFDNPTKPEWYCIEGGTSLLVDAMKETLVHKVQNNKRVEAISIDLDAPDDGNMSVKIGGKDYSGYSTVFNTTALGCLDRMDLRGLNLHPTQADAIRCLHYDNSTKVALKFSYPWWIKDCGITCGGAASTDLPLRTCVYPSYNLGDTGEAVLLASYTWSQDATRIGSLVKDAPPEDELVELILQNLARLHAEHMTYEKIKEAYTGVYHAYCWANDPNVGGAFALFGPGQFSNLYPYLMRPAAGGKFHIVGEASSVHHAWIIGSLESAYTAVYQFLYKYKMWDYLRLLLERWQYGL 7c3j A 2.20 BS02 PHE A 1 R68 A212 F216 Y369 W371 F439 A475 W476 R65 A209 F213 Y366 W368 F436 A472 W473 1.4.3.14 32894626 ELPPRKVCIVGAGVSGLYIAMILDDLKIPNLTYDIFESSSRTGGRLYTHHFTDAKHDYYDIGAMRYPDIPSMKRTFNLFKRTGMPLIKYYLDGENTPQLYNNHFFAKGVVDPYMVSVANGGTVPDDVVDSVGEKLQQAFGYYKEKLAEDFDKGFDELMLVDDMTTREYLKRGGPKGEAPKYDFFAIQWMETQNTGTNLFDQAFSESVIASFDFDNPTKPEWYCIEGGTSLLVDAMKETLVHKVQNNKRVEAISIDLDAPDDGNMSVKIGGKDYSGYSTVFNTTALGCLDRMDLRGLNLHPTQADAIRCLHYANSTKVALKFSYPWWIKDCGITCGGAASTDLPLRTCVYPSYNLGDTGEAVLLASYTWSQDATRIGSLVKDAPPQPPKEDELVELILQNLARLHAEHMTYEKIKEAYTGVYHAYCWANDPNVGGAFALFGPGQFSNLYPYLMRPAAGGKFHIVGEASSVHHAWIIGSLESAYTAVYQFLYKYKMWDYLRLLLERWQYGL 7c3j B 2.20 BS02 PHE B 1 R68 F216 Y369 W371 F439 A475 W476 R65 F213 Y366 W368 F436 A472 W473 1.4.3.14 32894626 ELPPRKVCIVGAGVSGLYIAMILDDLKIPNLTYDIFESSSRTGGRLYTHHFTDAKHDYYDIGAMRYPDIPSMKRTFNLFKRTGMPLIKYYLDGENTPQLYNNHFFAKGVVDPYMVSVANGGTVPDDVVDSVGEKLQQAFGYYKEKLAEDFDKGFDELMLVDDMTTREYLKRGGPKGEAPKYDFFAIQWMETQNTGTNLFDQAFSESVIASFDFDNPTKPEWYCIEGGTSLLVDAMKETLVHKVQNNKRVEAISIDLDAPDDGNMSVKIGGKDYSGYSTVFNTTALGCLDRMDLRGLNLHPTQADAIRCLHYANSTKVALKFSYPWWIKDCGITCGGAASTDLPLRTCVYPSYNLGDTGEAVLLASYTWSQDATRIGSLVKDAPPQPPKEDELVELILQNLARLHAEHMTYEKIKEAYTGVYHAYCWANDPNVGGAFALFGPGQFSNLYPYLMRPAAGGKFHIVGEASSVHHAWIIGSLESAYTAVYQFLYKYKMWDYLRLLLERWQYGL 7c5f O 1.88 BS01 NAD O 1 N7 G8 F9 G10 R11 I12 N33 D34 L35 K78 C96 T97 G98 F99 S120 A121 C150 T180 N315 F319 N9 G10 F11 G12 R13 I14 N35 D36 L37 K80 C98 T99 G100 F101 S122 A123 C152 T182 N317 F321 1.2.1.- 32880588 ASMSKVGINGFGRIGRLVLRRLLEVKSNIDVVAINDLTSPKILAYLLKHDSNYGPFPWSVDFTEDSLIVDGKSIAVYAEKEAKNIPWKAKGAEIIVECTGFYTSAEKSQAHLDAGAKKVLISAPAGEMKTIVYNVNDDTLDGNDTIVSVASCTTNCLAPMAKALHDSFGIEVGTMTTIHAYTGTQSLVDGPRGKDLRASRAAAENIIPHTTGAAKAIGLVIPELSGKLKGHAQRVPVKTGSVTELVSILGKKVTAEEVNNALKQATTNNESFGYTDEEIVSSDIIGSHFGSVFDATQTEITAVGDLQLVKTVAWYDNEYGFVTQLIRTLEKFAKL 7c7g A 1.86 BS02 FJR A 1 L54 Y55 W86 H117 S118 M120 L122 F306 F311 L50 Y51 W82 H113 S114 M116 L118 F302 F307 1.3.1.20 32847363 HQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYS 7c7g B 1.86 BS01 NAP B 1 G22 T23 Y24 D50 Y55 S166 N167 Q190 Y216 S217 L219 G220 S221 Q222 A253 L268 A269 K270 S271 Y272 R276 Q279 N280 F306 G17 T18 Y19 D45 Y50 S161 N162 Q185 Y211 S212 L214 G215 S216 Q217 A248 L263 A264 K265 S266 Y267 R271 Q274 N275 F301 1.3.1.20 32847363 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY 7c7g B 1.86 BS02 FJR B 1 L54 Y55 W86 H117 M120 L122 F139 F306 F311 L49 Y50 W81 H112 M115 L117 F134 F301 F306 1.3.1.20 32847363 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY 7c7h A 1.86 BS02 FJU A 1 L54 Y55 W86 S87 H117 M120 S121 L122 W227 F306 F311 L50 Y51 W82 S83 H113 M116 S117 L118 W223 F302 F307 1.3.1.20 32847363 HQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYS 7c7h B 1.86 BS02 FJU B 1 L54 Y55 W86 S87 H117 S118 M120 L122 F306 F311 L49 Y50 W81 S82 H112 S113 M115 L117 F301 F306 1.3.1.20 32847363 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY 7cbb A 2.60 BS01 AMP A 1 D146 R147 P148 S265 R267 R292 H424 Q426 D145 R146 P147 S264 R266 R291 H423 Q425 32880431 QNHTAVNTAQAIILRDLVDALLFEDIAGIVSNSEITKENGQTLLIYERETQQIKIPVYFSALNMFRYESSQPITIEGRVSKQPLTAAEFWQTIANMNCDLSHEWEVARVEEGLTTAATQLAKQLSELDLASHPFVMSEQFASLKDRPFHPLAKEKRGLREADYQVYQAELNQSFPLMVAAVKKTHMIHGDTANIDELENLTVPIKEQATDMLNDQGLSIDDYVLFPVHPWQYQHILPNVFATEISEKLVVLLPLKFGDYLSSSSMRSLIDIGAPYNHVKVPFAMQSLGALRLTPTRYMKNGEQAEQLLRQLIEKDEALAKYVMVCDETAWWSYMGQDNDIFKDQLGHLTVQLRKYPEVLAKNDTQQLVSMAALAANDRTLYQMICGKDNISKNDVMTLFEDIAQVFLKVTLSFMQYGALPELHGQNILLSFEDGRVQKCVLRDHDTVRIYKPWLTAHQLSLPKYVVREDTPNTLINEDLETFFAYFQTLAVSVNLYAIIDAIQDLFGVSEHELMSLLKQILKNEVATISWVTTDQLAVRHILFDKQTWPFKQILLPLLYQRMPSGLTTVPNPMVTY 7cbb B 2.60 BS01 AMP B 1 D146 R147 P148 K156 S265 R267 L288 R292 A372 H424 Q426 D145 R146 P147 K155 S264 R266 L287 R291 A371 H423 Q425 32880431 QNHTAVNTAQAIILRDLVDALLFEDIAGIVSNSEITKENGQTLLIYERETQQIKIPVYFSALNMFRYESSQPITIEGRVSKQPLTAAEFWQTIANMNCDLSHEWEVARVEEGLTTAATQLAKQLSELDLASHPFVMSEQFASLKDRPFHPLAKEKRGLREADYQVYQAELNQSFPLMVAAVKKTHMIHGDTANIDELENLTVPIKEQATDMLNDQGLSIDDYVLFPVHPWQYQHILPNVFATEISEKLVVLLPLKFGDYLSSSSMRSLIDIGAPYNHVKVPFAMQSLGALRLTPTRYMKNGEQAEQLLRQLIEKDEALAKYVMVCDETAWWSYMGQDNDIFKDQLGHLTVQLRKYPEVLAKNDTQQLVSMAALAANDRTLYQMICGKDNISKNDVMTLFEDIAQVFLKVTLSFMQYGALPELHGQNILLSFEDGRVQKCVLRDHDTVRIYKPWLTAHQLSLPKYVVNTLINEDLETFFAYFQTLAVSVNLYAIIDAIQDLFGVSEHELMSLLKQILKNEVATISWVTTDQLAVRHILFDKQTWPFKQILLPLLYLTTVPNPMVTY 7cgc A 2.55 BS01 AG A 1 D71 C113 L242 D71 C104 L233 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVALFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVN 7cgc A 2.55 BS02 AG A 2 C113 K142 N273 C104 K133 N264 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVALFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVN 7cgc A 2.55 BS03 AG A 3 I151 P172 V173 C251 I142 P163 V164 C242 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVALFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVN 7cgc B 2.55 BS02 AG B 2 K111 C113 K142 N273 G274 K100 C102 K131 N262 G263 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVNK 7cgc C 2.55 BS02 AG C 2 C113 L238 L242 G274 C104 L229 L233 G265 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVALFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVN 7cgc C 2.55 BS03 AG C 3 P172 V173 C251 P163 V164 C242 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVALFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVN 7cgc D 2.55 BS02 AG D 2 A112 C113 K142 A97 C98 K127 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVN 7cgd A 2.06 BS01 AG A 1 G69 A70 C109 G69 A70 C98 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVN 7cgd A 2.06 BS02 AG A 2 D71 K111 C113 L242 D71 K100 C102 L231 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVN 7cgd A 2.06 BS03 AG A 3 K111 C113 K142 N273 K100 C102 K131 N262 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVN 7cgd A 2.06 BS05 AG A 5 N119 H177 M227 N108 H166 M216 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVN 7cgd C 2.06 BS01 AG C 1 K111 A112 C113 K142 N273 K100 A101 C102 K131 N262 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVN 7cgd D 2.06 BS02 AG D 2 D71 A112 C113 L242 D71 A101 C102 L231 1.1.1.37 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVN 7cvn A 2.75 BS01 GJO A 1 V17 M18 E20 G21 R22 R25 G26 T27 G28 E29 L30 T31 V9 M10 E12 G13 R14 R17 G18 T19 G20 E21 L22 T23 3.1.3.11 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS 7cvn A 2.75 BS02 FBP A 1 D121 G122 S123 S124 N212 Y215 Y244 G246 S247 M248 Y264 K274 L275 D104 G105 S106 S107 N195 Y198 Y227 G229 S230 M231 Y247 K257 L258 3.1.3.11 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS 7cvn A 2.75 BS03 GJO C 1 R25 G26 T27 G28 R17 G18 T19 G20 3.1.3.11 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS 7cvn B 2.75 BS02 FBP B 1 D121 G122 S124 N212 Y215 Y244 G246 S247 M248 Y264 K274 E280 D104 G105 S107 N195 Y198 Y227 G229 S230 M231 Y247 K257 E263 3.1.3.11 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS 7cvn D 2.75 BS01 GJO B 1 R25 T27 G28 R17 T19 G20 3.1.3.11 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS 7cyw A 1.80 BS01 BUP A 1 M30 G31 T34 S276 G278 N279 V305 W340 V341 Q343 H358 G360 N362 S363 E366 M12 G13 T16 S256 G258 N259 V285 W312 V313 Q315 H330 G332 N334 S335 E338 2.4.1.- QPHVVVCSGAGMGHLTPFLNLASALSSAPYNCKVTLLIVIPLITDAESHHISSFFSSHPTIHRLDFHVNLPAPKPNVDPFFLRYKSISDSAHRLPVHLSALSPPISAVFSDFLFTQGLNTTLPHLPNYTFTTTSARFFTLMSYVPHLASSSSPVEIPGLEPFPTDNIPPPFFNPEHIFTSFTISNAKYFSLSKGILVNTFDSFEPETLSALNSGDTLSDLPPVIPIGPLNELEHNKQEELLPWLDQQPEKSVLYVSFGNRTAMSSDQILELGMGLERSDCRFIWVVKKSELRKLFGEELYLKLSEKGKLVKWVNQTEILGHTAVGGFLSHCGWNSVMEAARRGVPILAWPQHGDQRENAWVVEKAGLGVWEREWASGIQAAIVEKVKMIMGNNDLRKSAMKVGEEAKRACDVGGSSATALMNIIGSLK 7d1o A 1.78 BS01 NNA A 1 T25 T26 H41 M49 L141 N142 G143 S144 C145 H164 M165 E166 L167 P168 D187 R188 Q189 T190 A191 Q192 T25 T26 H41 M49 L141 N142 G143 S144 C145 H164 M165 E166 L167 P168 D187 R188 Q189 T190 A191 Q192 3.4.22.69 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCS 7jkv A 1.25 BS01 V7G A 1 T25 H41 M49 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 P168 H172 D187 Q189 T190 A191 T25 H41 M49 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 P168 H172 D187 Q189 T190 A191 3.4.22.69 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCS 7jkv B 1.25 BS01 V7G B 1 T25 L27 H41 M49 F140 N142 G143 S144 C145 H163 H164 M165 E166 H172 Q189 T190 A191 T26 L28 H42 M50 F141 N143 G144 S145 C146 H164 H165 M166 E167 H173 Q190 T191 A192 3.4.22.69 GSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCS 7jv8 A 2.46 BS04 VPD A 1 D36 H38 D85 N117 H118 D121 L184 N186 H243 R354 N390 G392 G393 R395 F417 G447 F500 D506 D12 H14 D61 N93 H94 D97 L160 N162 H219 R330 N366 G368 G369 R371 F393 G423 F476 D482 3.1.3.5 32865411 SMWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS 7jv8 C 2.46 BS04 VPD C 1 D36 D85 N117 H118 D121 L184 H243 R354 N390 G392 G393 R395 F417 G447 F500 D506 D14 D63 N95 H96 D99 L162 H221 R332 N368 G370 G371 R373 F395 G425 F478 D484 3.1.3.5 32865411 LASMWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFSHH 7jv9 A 2.70 BS04 VPG A 1 D85 N117 H118 D121 L184 N186 H243 N390 G392 R395 F417 G447 F500 D506 D61 N93 H94 D97 L160 N162 H219 N366 G368 R371 F393 G423 F476 D482 3.1.3.5 32865411 SMWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS 7k1l A 2.25 BS01 UVC A 1 H235 L246 G247 G248 H250 K290 V292 C293 S294 T341 Y343 H236 L247 G248 G249 H251 K291 V293 C294 S295 T342 Y344 3.1.-.- NMSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKL 7k1o A 2.40 BS01 VQV A 1 H235 G247 G248 H250 K290 W333 T341 H235 G247 G248 H250 K290 W333 T341 3.1.-.- MSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKL 7k1o B 2.40 BS01 VQV B 1 H235 G248 H250 K290 W333 E340 T341 H236 G249 H251 K291 W334 E341 T342 3.1.-.- NMSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKL 7k1o C 2.40 BS01 VQV C 1 H235 G247 G248 H250 K290 W333 E340 T341 H236 G248 G249 H251 K291 W334 E341 T342 3.1.-.- NMSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKL 7k3u B 2.70 BS01 MN B 1 F190 D221 D232 T234 E325 E339 F190 D221 D232 T234 E325 E339 3.4.13.9 28179139 MSKIERISAFLNDKEVDMTFITNPTTLNYLTGLAIDPHERIAGLMIFRDSTPMLFTPALEVEKAKEHTSGLDIFGYEDSQNPWEVVKNHVKSDVKSIAVEFSDIPLAKTEGLKAQFGDINFVNLTPLIERMRLIKSADEIEKMKVAGDFADKCFEIGFATAAERNGVTESDIVAKIEYEMKRMGVPQMSFDTLVLSGARAANPHGAPENVEIQENKLLLFDLGVMSGGYASDATRTIAIGQPNDFDAEIHKIVKEAQQAAMDFIKPGVTAHEVDAVARDLITKAGYGEYFNHSLGHGIGMDVHEYPSIVAGNDLVIQEGMCFSNEPGIYIPGKVGVRIEDCLYVTENGCESFTHTDHDLLIF 7k3u D 2.70 BS01 MN D 1 D232 H296 H303 S323 E325 E339 D232 H296 H303 S323 E325 E339 3.4.13.9 28179139 MSKIERISAFLNDKEVDMTFITNPTTLNYLTGLAIDPHERIAGLMIFRDSTPMLFTPALEVEKAKEHTSGLDIFGYEDSQNPWEVVKNHVKSDVKSIAVEFSDIPLAKTEGLKAQFGDINFVNLTPLIERMRLIKSADEIEKMKVAGDFADKCFEIGFATAAERNGVTESDIVAKIEYEMKRMGVPQMSFDTLVLSGARAANPHGAPENVEIQENKLLLFDLGVMSGGYASDATRTIAIGQPNDFDAEIHKIVKEAQQAAMDFIKPGVTAHEVDAVARDLITKAGYGEYFNHSLGHGIGMDVHEYPSIVAGNDLVIQEGMCFSNEPGIYIPGKVGVRIEDCLYVTENGCESFTHTDHDLLIF 7k3u H 2.70 BS02 MN H 2 D232 H296 H303 E325 E339 D232 H296 H303 E325 E339 3.4.13.9 28179139 MSKIERISAFLNDKEVDMTFITNPTTLNYLTGLAIDPHERIAGLMIFRDSTPMLFTPALEVEKAKEHTSGLDIFGYEDSQNPWEVVKNHVKSDVKSIAVEFSDIPLAKTEGLKAQFGDINFVNLTPLIERMRLIKSADEIEKMKVAGDFADKCFEIGFATAAERNGVTESDIVAKIEYEMKRMGVPQMSFDTLVLSGARAANPHGAPENVEIQENKLLLFDLGVMSGGYASDATRTIAIGQPNDFDAEIHKIVKEAQQAAMDFIKPGVTAHEVDAVARDLITKAGYGEYFNHSLGHGIGMDVHEYPSIVAGNDLVIQEGMCFSNEPGIYIPGKVGVRIEDCLYVTENGCESFTHTDHDLLIF 7k3u I 2.70 BS02 MN I 2 F190 D221 D232 T234 R337 E339 F190 D221 D232 T234 R337 E339 3.4.13.9 28179139 MSKIERISAFLNDKEVDMTFITNPTTLNYLTGLAIDPHERIAGLMIFRDSTPMLFTPALEVEKAKEHTSGLDIFGYEDSQNPWEVVKNHVKSDVKSIAVEFSDIPLAKTEGLKAQFGDINFVNLTPLIERMRLIKSADEIEKMKVAGDFADKCFEIGFATAAERNGVTESDIVAKIEYEMKRMGVPQMSFDTLVLSGARAANPHGAPENVEIQENKLLLFDLGVMSGGYASDATRTIAIGQPNDFDAEIHKIVKEAQQAAMDFIKPGVTAHEVDAVARDLITKAGYGEYFNHSLGHGIGMDVHEYPSIVAGNDLVIQEGMCFSNEPGIYIPGKVGVRIEDCLYVTENGCESFTHTDHDLLIF 7k40 A 1.35 BS01 U5G A 1 H41 M49 Y54 N142 G143 S144 C145 H164 M165 E166 L167 P168 D187 Q189 T190 Q192 H41 M49 Y54 N142 G143 S144 C145 H164 M165 E166 L167 P168 D187 Q189 T190 Q192 3.4.22.69 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ