5o9b A BS01 ZN A 1 C7 C10 C28 C31 C26 C29 C47 C50 MAHHHHHHSSGLEVLFQGPRRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKE 5ovg A 2.30 BS01 AWZ A 1 N879 Y884 D887 F890 L901 E902 H905 E906 N290 Y295 D298 F301 L312 E313 H316 E317 30683722 AEEQMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDTFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSN 5ovh A 2.30 BS01 AWW A 1 M878 N879 V883 Y884 L886 F890 L901 E902 H905 M288 N289 V293 Y294 L296 F300 L311 E312 H315 30683722 GAMAEEQMRLPSADVYRFAEPDSEENIIFEAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNP 5ovi A 2.20 BS01 AXH A 1 M878 N879 V883 Y884 L886 D887 F890 L901 E902 H905 M300 N301 V305 Y306 L308 D309 F312 L323 E324 H327 30683722 QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDTFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSN 5oy5 A 2.60 BS01 BLA A 1 C20 I25 Y170 Y197 D201 I202 P203 Y210 R216 M250 S251 I253 H254 Y257 V268 L280 A282 H284 P467 S470 C13 I18 Y163 Y190 D194 I195 P196 Y203 R209 M243 S244 I246 H247 Y250 V261 L273 A275 H277 P451 S454 GSPAFGTADLSNCEREEIHLAGSIQPHGALLVVSEPDHRIIQASANAAEFLNLGSVLGVPLAEIDGDLLIKILPHLDPTAEGMPVAVRCRIGNPSTEYDGLMHRPPEGGLIIELERAGPPIDLSGTLAPALERIRTAGSLRALCDDTALLFQQCTGYDRVMVYRFDEQGHGEVFSERHVPGLESYFGNRYPSSDIPQMARRLYERQRVRVLVDVSYQPVPLEPRLSPLTGRDLDMSGCFLRSMSPIHLQYLKNMGVRATLVVSLVVGGKLWGLVACHHYLPRFIHFELRAICELLAEAIATRITALESFAQSQSELFVQRLEQRMIEAITREGDWRAAIFDTSQSILQPLHADGCALVYEDQIRTIGDVPSTQDVREIAGWLDRQPRAAVTSTASLGLDVPELAHLTRMASGVVAAPISDHRGEFLMWFRPERVHTVTWGGMGDTPADLSPRRSFAKWHQVVEGTSDPWTAADLAAARTIGQTVADIVLQF 5qj2 B 2.82 BS02 HEM B 1 R239 E242 M243 T329 F332 R333 G335 H336 I339 F365 L406 F407 L417 L420 R424 R127 E130 M131 T217 F220 R221 G223 H224 I227 F253 L294 F295 L305 L308 R312 1.11.2.2 30613322 VNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 5qj2 B 2.82 BS03 JXS B 1 T238 R239 E242 F366 F407 T126 R127 E130 F254 F295 1.11.2.2 30613322 VNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 5qj2 G 2.82 BS02 HEM G 1 R239 E242 M243 T329 F332 R333 G335 H336 I339 F407 L417 R424 R127 E130 M131 T217 F220 R221 G223 H224 I227 F295 L305 R312 1.11.2.2 30613322 VNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 5qj2 I 2.82 BS02 HEM I 1 R239 E242 M243 T329 F332 R333 Y334 G335 H336 I339 L361 F365 L406 F407 L417 R424 R127 E130 M131 T217 F220 R221 Y222 G223 H224 I227 L249 F253 L294 F295 L305 R312 1.11.2.2 30613322 VNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 5qj3 B 2.76 BS04 JXP B 1 P220 T238 R239 E242 F366 F407 V410 M411 P107 T125 R126 E129 F253 F294 V297 M298 1.11.2.2 30613322 NCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 5ya6 A 1.50 BS01 CA A 1 D139 D141 S143 N150 D153 D93 D95 S97 N104 D107 ASGLMCIGVTGHYDKTLGGIDKLAIYITPNAGSAPIDLKNAKLFLIYDGESHVLNYSTVTTATLGADDIFNSSAITDWSLADSSSYVVGVIQDADGSLSNGVINKGDIAVLLVNANAVFNKAIPTRSEVSGQFQPEFGAPAVIQFTTPAAYTQTVIELQHHHH 5z87 A 2.30 BS01 MG A 1 T538 R552 R583 L585 T509 R523 R554 L556 NQASDDYRDRSLSPARRAAALANLMTLDEMAAQLNCPRAADVMSDPAGFEADFPYFAHGIGGVYSASLEAGPEDNARAVMAMQQEVVSRSRFGIPAFVFEECLHGLLADGATQFPQAMAMACAFRPDMVRQVFEATAKEARSRGSQGCFSPNIDICTDPRWGRSEETWGEDPHVVTVSAKAIVEGLQGAPAEYLPANRIATSVKHFAGYGQGIGGRNFAPSHIGPVEMQNVVLPPFRAAITEAGSIGLMASHGEIDGVPAHADTHLLNDVLRDDWGFEGYVVSDWDDVRRIHSLHGVAGSEAEAAIMGLRAGVDIELANNGVYLMLPQLVRDGLLEERYVRRAAERILAAKFKCGLFDMPFADPALAGRLARSTEHKLLARRMAEESIVLLQNEGNVLPLQSSAVRKMLVVGPNAASVHLGGYSPKPFVGVSALEGLQAYAEQAGFEVEYAQGCAITAGDEGNNEIETDASDESVQADPARNRRLIAEAVATAQDCDVIVMCLGGNESTAREAYFAGDSRGDRDDLELIGEQNELAEALLALGKTTVAVLIHGRPLSPLVLAENCPAILDAFYPGEQGGHAIASILFGDVNPSGKLPVTIVRNVGQLPGYYYQKPTGRFRNYVFSDSTPLYPFGHGLSYTSFGYGAPQAERASIGLQDRLRVSVSVRNTGDRAGQDVVQLYIRDSIASRARPIKEMRGFQKVLLEPGEVQVVQFELGPEDFGYRDADGKLLVEPGEIVIMAGPDSQNLQETRITLV 5z87 A 2.30 BS02 MG A 2 D713 I715 D684 I686 NQASDDYRDRSLSPARRAAALANLMTLDEMAAQLNCPRAADVMSDPAGFEADFPYFAHGIGGVYSASLEAGPEDNARAVMAMQQEVVSRSRFGIPAFVFEECLHGLLADGATQFPQAMAMACAFRPDMVRQVFEATAKEARSRGSQGCFSPNIDICTDPRWGRSEETWGEDPHVVTVSAKAIVEGLQGAPAEYLPANRIATSVKHFAGYGQGIGGRNFAPSHIGPVEMQNVVLPPFRAAITEAGSIGLMASHGEIDGVPAHADTHLLNDVLRDDWGFEGYVVSDWDDVRRIHSLHGVAGSEAEAAIMGLRAGVDIELANNGVYLMLPQLVRDGLLEERYVRRAAERILAAKFKCGLFDMPFADPALAGRLARSTEHKLLARRMAEESIVLLQNEGNVLPLQSSAVRKMLVVGPNAASVHLGGYSPKPFVGVSALEGLQAYAEQAGFEVEYAQGCAITAGDEGNNEIETDASDESVQADPARNRRLIAEAVATAQDCDVIVMCLGGNESTAREAYFAGDSRGDRDDLELIGEQNELAEALLALGKTTVAVLIHGRPLSPLVLAENCPAILDAFYPGEQGGHAIASILFGDVNPSGKLPVTIVRNVGQLPGYYYQKPTGRFRNYVFSDSTPLYPFGHGLSYTSFGYGAPQAERASIGLQDRLRVSVSVRNTGDRAGQDVVQLYIRDSIASRARPIKEMRGFQKVLLEPGEVQVVQFELGPEDFGYRDADGKLLVEPGEIVIMAGPDSQNLQETRITLV 5z87 A 2.30 BS03 MG A 3 D292 H294 D263 H265 NQASDDYRDRSLSPARRAAALANLMTLDEMAAQLNCPRAADVMSDPAGFEADFPYFAHGIGGVYSASLEAGPEDNARAVMAMQQEVVSRSRFGIPAFVFEECLHGLLADGATQFPQAMAMACAFRPDMVRQVFEATAKEARSRGSQGCFSPNIDICTDPRWGRSEETWGEDPHVVTVSAKAIVEGLQGAPAEYLPANRIATSVKHFAGYGQGIGGRNFAPSHIGPVEMQNVVLPPFRAAITEAGSIGLMASHGEIDGVPAHADTHLLNDVLRDDWGFEGYVVSDWDDVRRIHSLHGVAGSEAEAAIMGLRAGVDIELANNGVYLMLPQLVRDGLLEERYVRRAAERILAAKFKCGLFDMPFADPALAGRLARSTEHKLLARRMAEESIVLLQNEGNVLPLQSSAVRKMLVVGPNAASVHLGGYSPKPFVGVSALEGLQAYAEQAGFEVEYAQGCAITAGDEGNNEIETDASDESVQADPARNRRLIAEAVATAQDCDVIVMCLGGNESTAREAYFAGDSRGDRDDLELIGEQNELAEALLALGKTTVAVLIHGRPLSPLVLAENCPAILDAFYPGEQGGHAIASILFGDVNPSGKLPVTIVRNVGQLPGYYYQKPTGRFRNYVFSDSTPLYPFGHGLSYTSFGYGAPQAERASIGLQDRLRVSVSVRNTGDRAGQDVVQLYIRDSIASRARPIKEMRGFQKVLLEPGEVQVVQFELGPEDFGYRDADGKLLVEPGEIVIMAGPDSQNLQETRITLV 5z88 A 3.00 BS01 SIA A 1 Y94 S132 G133 V134 S135 S136 W152 H182 E189 L193 Q225 S227 Y92 S130 G131 V132 S133 S134 W150 H180 E187 L191 Q223 S225 GDRICIGYHANNSTTQVDTIMEKNVTVTHAQDILEKEHNGRLCSLKGVKPLILKNCSVAGWLLGNPMCDEFLNAPEWSYIVEKDRPSNGLCYPGTFNYYEELKHLMSSTNQFEKIQIFPRSSWSNHDASSGVSSACPYNGRSSFFRNVVWLIKKNNVYRTITRTYNNTNIEDLLIIWGIHHPNNAAEQIKLYQNPSTYVSVGTSTLNQRSIPEIATRPKVNGQSSRMEFFWTILRPNDSITFESTGNFIAPEYAYKIVKKGDSAIMKSELSYSNCDTKCQTPVGAINSSMPFHNVHPFAIGECPKYVKLKKLVLATGLRNIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAVDGITNKVNSIISKMNSQFEAVGKEFNNLERRIENLNKKMEDGFIDVWTYNAELLVLMENERTLDLHDSNVKNLYDKVRRQLRDNAKELGNGCFEFYHRCDNKCMESVRNGTYDYPQYSEESRLKREEIDSGL 5z8g A 1.70 BS01 99L A 1 W81 P82 F83 V87 L92 Y97 Y139 N140 D145 I146 M149 W40 P41 F42 V46 L51 Y56 Y98 N99 D104 I105 M108 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 5z8h A 1.79 BS01 III B 1 F458 R463 M503 T506 N507 F510 G511 K516 Q542 V543 R549 N550 W553 K586 S590 W593 N594 A597 R640 N641 F50 R55 M95 T98 N99 F102 G103 K108 Q134 V135 R141 N142 W145 K178 S182 W185 N186 A189 R232 N233 HHHMLHLLEQIRAYCETCWEWQEAHEPNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDAN 5z8t A 2.33 BS01 FAD A 1 L89 N127 S128 A130 T131 G136 S137 P138 R140 F163 T165 A368 H371 N372 L90 N128 S129 A131 T132 G137 S138 P139 R141 F164 T166 A369 H372 N373 AMYDIYGEAALPADVRERLRITRDLAQAFHERAPEHDRAGDFPFENIEDLKASGYVRWTVPVEYGGLGLSLEEMLMHQEVLAKGDGSTALAIGWHVGILLHLRETGAFPDELFRMVCESVVKEGALINSCATEPATGSPSRGGKPETTAVKVPGGYRITGRKTFSTLSPALTWIMVTATVADEDVVGQFLVRKEDVEIVETWDTLGMRATGSHDIVLKDVFVPEERVIVIQRPGVQAERRPDGSGWLLHIPACYLGIALAARDFALEYAATYRPNTLPHPIAEVPHVEQKLGEMELKLLAARTLLYDLARRFDAASPEERVKLQPQFGAVKTLATNAANQVVDLAMRVVGGRSLSRALPLERYYRDVRAGLHNPPMDDVVYRNLAKAALARRAAG 5z8t B 2.33 BS02 FAD C 1 Y271 P273 T275 L276 I280 V283 H285 R346 V347 V348 G349 G350 L353 Y272 P274 T276 L277 I281 V284 H286 R347 V348 V349 G350 G351 L354 AMYDIYGEAALPADVRERLRITRDLAQAFHERAPEHDRAGDFPFENIEDLKASGYVRWTVPVEYGGLGLSLEEMLMHQEVLAKGDGSTALAIGWHVGILLHLRETGAFPDELFRMVCESVVKEGALINSCATEPATGSPSRGGKPETTAVKVPGGYRITGRKTFSTLSPALTWIMVTATVADEDVVGQFLVRKEDVEIVETWDTLGMRATGSHDIVLKDVFVPEERVIVIQRPGVQAERRPDGSGWLLHIPACYLGIALAARDFALEYAATYRPNTLPHPIAEVPHVEQKLGEMELKLLAARTLLYDLARRFDAASPEERVKLQPQFGAVKTLATNAANQVVDLAMRVVGGRSLSRALPLERYYRDVRAGLHNPPMDDVVYRNLAKAALARRAAG 5z8u A 1.90 BS01 MG A 1 E27 E62 H65 Q141 E22 E57 H60 Q136 1.16.3.1 SRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALNNFSRYFLHQSREETEHAEKLMRLQNQRGGRIRLQDIKKPEQDDWESGLHAMEAALLLEKNVNQSLLELHALASDKGDPHLADFLETYYLNEQVKSIKELGDHVHNLVKMGAPDAGLAEYLFDTHTLG 5z91 A 3.00 BS01 AU A 1 D126 P127 C130 D121 P122 C125 1.16.3.1 SRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALNNFSRYFLHQSREETEHAEKLMRLQNQRGGRIRLQDIKKPEQDDWESGLHAMECALLLEKNVNQSLLELHALASDKGDPHLCDFLETYYLNEQVKSIKELGDHVHNLVKMGAPDAGLAEYLFDTHTLG 5z93 A 1.95 BS01 III B 1 F180 Q228 I230 H248 V292 F294 G295 E296 P297 L298 E323 V324 E325 P326 F59 Q107 I109 H127 V171 F173 G174 E175 P176 L177 E202 V203 E204 P205 3.5.1.- KLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLD 5z94 A 1.90 BS01 III C 1 F180 Q228 I230 H248 V292 F293 F294 G295 E296 E323 V324 E325 P326 F59 Q107 I109 H127 V171 F172 F173 G174 E175 E202 V203 E204 P205 3.5.1.- KLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKL 5z9i A 2.20 BS01 HEM A 1 F75 A76 H83 R87 I138 L234 N237 G238 T241 T242 M278 R289 G339 F340 H345 C347 G349 A353 F69 A70 H77 R81 I132 L222 N225 G226 T229 T230 M266 R277 G327 F328 H333 C335 G337 A341 AQWEFHPGHFWMRGKRPDKIVDYDEELQLWNVYGYPESAAILSNPKVFSSDTMRLDPIKLDEAIVEGDFAHTDPPKHRRLRGLVDHAFTPSLVAKMESRVHGIIHELLDGVEGKSQFDLVAEFAAPLPLIMISDLLGVPESDRALFRQWMDKMLDGSEKVLEQEEELHKELELLWEMRDYWHERAAESRKRPREDLISQLVHAEVDGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQDARVRADRSLVPALLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGRSPNAHLGFGRGIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPPTFLQVVDASGVATLPVVTQ 5z9j A 2.00 BS01 HEM A 1 F75 A76 H83 R87 R233 L234 N237 G238 T241 T242 L245 R289 G339 L340 G341 I344 H345 C347 L348 G349 A353 F69 A70 H77 R81 R227 L228 N231 G232 T235 T236 L239 R283 G333 L334 G335 I338 H339 C341 L342 G343 A347 AQWEFHPGHFWMRGKRPDKIVDYDEELQLWNVYGYPESAAILSNPKVFSSDTMRLDPIKLDEAIVEGDFAHTDPPKHRRLRGLVDHAFTPSLVAKMESRVHGIIHELLDGVEGKSQFDLVAEFAAPLPLIMISDLLGVPESDRALFRQWMDKMLDGSEKFESPETVLEQEEELHKELELLWEMRDYWHERAAESRKRPREDLISQLVHAEVDGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQDARVRADRSLVPALLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGRSPNAHLGLGRGIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPPTFLQVVDASGVATLPVVT 5z9j B 2.00 BS01 HEM B 1 F75 A76 H83 R87 L234 N237 G238 T241 L245 I284 V287 R289 G339 L340 G341 H345 C347 G349 L352 A353 F67 A68 H75 R79 L203 N206 G207 T210 L214 I253 V256 R258 G308 L309 G310 H314 C316 G318 L321 A322 WEFHPGHFWMRGKRPDKIVDYDEELQLWNVYGYPESAAILSNPKVFSSDTMRLDPIKLDEAIVEGDFAHTDPPKHRRLRGLVDHAFTPSLVAKMESRVHGIIHELLDGVEGKSQFDLVAEFAAPLPLIMISDLLGVPESDRALFRQWMDKMLELLWEMRDYWHERAAESRKRPREDLISQLVHAEVDGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQDARVRADRSLVPALLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGRSPNAHLGLGRGIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPPTFLQVVDASGVATLPVVTQ 5z9j D 2.00 BS01 HEM D 1 F75 A76 H83 R87 L234 N237 G238 T241 T242 I284 R289 G339 L340 G341 H345 C347 G349 L352 A353 F67 A68 H75 R79 L209 N212 G213 T216 T217 I259 R264 G314 L315 G316 H320 C322 G324 L327 A328 WEFHPGHFWMRGKRPDKIVDYDEELQLWNVYGYPESAAILSNPKVFSSDTMRLDPIKLDEAIVEGDFAHTDPPKHRRLRGLVDHAFTPSLVAKMESRVHGIIHELLDGVEGKSQFDLVAEFAAPLPLIMISDLLGVPESDRALFRQWMDKMLDGHKELELLWEMRDYWHERAAESRKRPREDLISQLVHAEVDGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQDARVRADRSLVPALLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGRSPNAHLGLGRGIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPPTFLQVVDASGVATLPVVTQ 5ze9 A 2.10 BS01 ANP A 1 F234 G235 A236 G237 K238 T239 V240 R262 F425 N504 A505 F506 F235 G236 A237 G238 K239 T240 V241 R263 F426 N505 A506 F507 3.6.3.15 GMQIGKIIKVSGPLVMAENMSEASIQDMCLVGDLGVIGEIIEMRQDVASIQVYEETSGIGPGEPVRSTGEALSVELGPGIISQMFDGIQRPLDTFMEVTQSNFLGRGVQLPALDHEKQWWFEATIEEGTEVSAGDIIGYVDETKIIQHKIMVPNGIKGTVQKIESGSFTIDDPICVIETEQGLKELTMMQKWPVRRGRPIKQKLNPDVPMITGQRVIDTFFPVTKGGAAAVPGPFGAGKTVVQHQIAKWSDVDLVVYVGCGERGNEMTDVVNEFPELIDPNTGESLMERTVLIANTSNMPVAAREASIYTGITIAEYFRDMGYDVAIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGSRLAEYYERSGRVIALGSDQREGSITAISAVSPSGGDISEPVTQNTLRVVKVFWGLDSSLAQKRHFPSINWIQSYSLYSTEVGRYMDQILQQDWSDMVTEGMRILQEEEQLNEIVRLVGIDSLSDNDRLTLEVAKSIREDYLQQNAFDDVDTFTSREKQFNMLKVILTFGKEARKALSLGAYFNEIMEGTVAVRERISRSKYIPEEELAKISSINEEIKETIQLIVSE 5ze9 F 2.10 BS01 ANP C 1 G320 Y321 R350 K352 G321 Y322 R351 K353 GMIKEYRTIKEVVGPLMAVEKVSGVKYEELIEVRMQNGEIRRGQVLEVQEDKAMVQIFEGTSGINYKNSSVRFLGHPLQLGVSEDMIGRVFDGLGRPKDNGPEILPEKYLDINGEVINPIARDYPDEFIQTGISAIDHLNTLVRGQKLPVFSGSGLPHKELAAQIARQATVLDSSDDFAVVFAAIGITFEEAEFFMEDFRQTGAIDRSVMFMNLANDPAIERIATPRMALTAAEYLAYEKGMHVLVIMTDMTNYAEALREISAARREVPGRRGYPGYLYTNLATLFERAGRIRGLKGSVTQIPILTMPEDDKTHPIPDLTGYITEGQIILTRELYKSGIQPPIDVLPSLSRLKDKGTGAGKTREDHAATMNQLFAAYAQGKQAKELAVVLGESALSDIDKIYAKFAERFENEYVNQGFYTNRTITETLDLGWELLAMLPRTELKRIKDDLLDKYLP 5zmp A 2.19 BS01 ZN A 1 D164 H166 D248 D164 H166 D248 MIHLIYSDQFLDHGTGRSHPESARRLTAIAQALKAVSWANQIQWHEPTAIAFRDPLPWVRQLHDDYYLKELQKLAESGGGYWDPDTPVSPQSFDVALLAVNACLDGVDLALQTKEPVFALVRPPGHHATRSTGMGFCLLGNVAIAAHYALGLAGIKKVAILDWDVHHGNGTEYLVEENPQIIYCSLHQDPAYPGTGQAHHHGRHQNILNIPLKPGADRRIYVQKFQDVVLPYLQEFQPDLLIVSAGYDATAKDPLAGMNLQPQDYKVFSEFCQQLPCPILFALEGGYHLQTLAESVVATLEPFAQ 6a2w A 1.80 BS01 CA A 1 E72 E82 E72 E82 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS02 A86 A 1 P11 N142 R145 A146 M149 P11 N142 R145 A146 M149 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS03 A86 A 2 K38 I42 T62 I63 D64 Y65 L91 I95 L98 M103 F116 K38 I42 T62 I63 D64 Y65 L91 I95 L98 M103 F116 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS04 A86 A 3 F15 P17 L18 I42 S43 A46 Y50 Q53 G76 F80 Q148 M149 I151 L152 F15 P17 L18 I42 S43 A46 Y50 Q53 G76 F80 Q148 M149 I151 L152 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS05 A86 A 4 S101 V102 L106 T107 F116 R117 A120 I121 F123 K136 S101 V102 L106 T107 F116 R117 A120 I121 F123 K136 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS06 A86 A 5 M44 V47 V48 F123 Q143 A146 A147 G150 A153 L154 L164 L165 M44 V47 V48 F123 Q143 A146 A147 G150 A153 L154 L164 L165 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS07 A86 A 6 L20 Q159 L20 Q159 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS08 A86 A 7 L51 A55 L165 P166 L51 A55 L165 P166 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS09 CLA A 1 Q9 P11 A138 I139 N142 Q143 Q9 P11 A138 I139 N142 Q143 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS10 CLA A 2 F2 E5 L6 G7 L12 G13 F14 F15 D16 L20 L32 R33 V35 E36 H39 R145 Q148 M149 F2 E5 L6 G7 L12 G13 F14 F15 D16 L20 L32 R33 V35 E36 H39 R145 Q148 M149 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS11 KC2 A 1 R31 L32 V35 H39 R31 L32 V35 H39 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS12 CLA A 3 L45 A46 G49 Q53 V57 R58 L59 F70 I73 P74 A79 I83 M103 L45 A46 G49 Q53 V57 R58 L59 F70 I73 P74 A79 I83 M103 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS13 CLA A 4 I63 D64 Y65 P84 G86 G87 Q90 L91 F94 I63 D64 Y65 P84 G86 G87 Q90 L91 F94 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS14 CLA A 5 Y34 V35 K38 H39 I42 L92 I95 G96 E99 Y34 V35 K38 H39 I42 L92 I95 G96 E99 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS15 CLA A 6 R41 M44 L45 F112 D115 F116 R117 F123 G124 W125 T127 F128 R137 I139 E140 R41 M44 L45 F112 D115 F116 R117 F123 G124 W125 T127 F128 R137 I139 E140 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS16 KC1 A 1 K136 Q143 K136 Q143 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6a2w A 1.80 BS17 CLA A 7 M149 A153 V156 H157 L160 V162 L164 M149 A153 V156 H157 L160 V162 L164 AFEDELGAQPPLGFFDPLGLVADGDQEKFDRLRYVEIKHGRISMLAVVGYLVQEAGVRLPGTIDYSGKTFAEIPNGFAAFKEIPAGGLVQLLFFIGVLESSVMRDLTGEAEFVGDFRNGAIDFGWDTFDEETQFKKRAIELNQGRAAQMGILALMVHEQLGVSLLP 6adm A 2.84 BS01 III D 1 K34 F35 D38 R120 D122 V181 P183 N243 K34 F35 D38 R120 D122 V181 P183 N243 30514821 STDNAETGVIEAGNTDTDFSGELAAPGSNHTNVKFLFDRSRLLNVIKVLEKDAVFPRPFPTQEGAQQDDGYFCLLTPRPTVASRPATRFGLYANPSGSGVLANTSLDFNFYSLACFTYFRSDLEVTVVSLEPDLEFAVGWFPSGSEYQASSFVYDQLHVPFHFTGRTPRAFASKGGKVSFVLPWNSVSSVLPVRWGGASKLSSATRGLPAHADWGTIYAFVPRPNEKKSTAVKHVAVYIRYKNARAWCPSMLPFRSYK 6adm A 2.84 BS02 III D 2 T7 V9 P249 T7 V9 P249 30514821 STDNAETGVIEAGNTDTDFSGELAAPGSNHTNVKFLFDRSRLLNVIKVLEKDAVFPRPFPTQEGAQQDDGYFCLLTPRPTVASRPATRFGLYANPSGSGVLANTSLDFNFYSLACFTYFRSDLEVTVVSLEPDLEFAVGWFPSGSEYQASSFVYDQLHVPFHFTGRTPRAFASKGGKVSFVLPWNSVSSVLPVRWGGASKLSSATRGLPAHADWGTIYAFVPRPNEKKSTAVKHVAVYIRYKNARAWCPSMLPFRSYK 6adm C 2.84 BS01 III D 1 P19 D20 D21 T22 V23 P24 N28 V29 R30 T31 P32 P18 D19 D20 T21 V22 P23 N27 V28 R29 T30 P31 30514821 PIPTAPRENSLMFLSTLPDDTVPAYGNVRTPPVNYLPGEITDLLQLARIPTLMAFERTYVPYVAVPTQFDDRPLISFPITLSDPVYQNTLVGAISSNFANYRGCIQITLTFCGPMMARGKFLLSYSPPNGTQPQTLSEAMQCTYSIWDIGLNSSWTFVVPYISPSDYRETRAITNSVYSADGWFSLHKLTKITLPPDCPQSPCILFFASAGEDYTLRLPVDCNPSYVF 6adm C 2.84 BS02 III D 3 D43 Q46 R49 D42 Q45 R48 30514821 PIPTAPRENSLMFLSTLPDDTVPAYGNVRTPPVNYLPGEITDLLQLARIPTLMAFERTYVPYVAVPTQFDDRPLISFPITLSDPVYQNTLVGAISSNFANYRGCIQITLTFCGPMMARGKFLLSYSPPNGTQPQTLSEAMQCTYSIWDIGLNSSWTFVVPYISPSDYRETRAITNSVYSADGWFSLHKLTKITLPPDCPQSPCILFFASAGEDYTLRLPVDCNPSYVF 6adm B 2.84 BS01 III D 4 G31 V32 L33 C34 Y36 V37 E38 G20 V21 L22 C23 Y25 V26 E27 30514821 DRVTTQTAGNTAINTQSSLGVLCAYVEDPTKSDPPSSSTDQPTTTFTAIDRWYTGRLNSWTKAVKTFSFQAVPLPGAFLSRQGGLNGGAFTATLHRHFLMKCGWQVQVQCNLTQFHQGALLVAMVPETTLDVKPDGKAKSLQELNEEQWVEMSDDYRTGKNMPFQSLGTYYRPPNWTWGPNFINPYQVTVFPHQILNARTSTSVDINVPYIGETPTQSSETQNSWTLLVMVLVPLDYKEGATTDPEITFSVRPTSPYFNGLRNRYTA 6adm R 2.84 BS01 MG R 1 S52 S54 T118 D150 S17 S19 T83 D115 30514821 SMACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYAVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSC 6adr A 3.38 BS01 III D 1 K34 D38 R120 D122 V181 N243 K34 D38 R120 D122 V181 N243 30514821 STDNAETGVIEAGNTDTDFSGELAAPGSNHTNVKFLFDRSRLLNVIKVLEKDAVFPRPFPTATGTQQDDGYFCLLTPRPTVASRPATRFGLYVSPSDSGVLANTSLDFNFYSLACFTYFRSDLEVTVVSLEPDLEFAVGWFPSGSEYQASSFVYDQLHVPYHFTGRTPRAFASKGGKVSFVLPWNSVSSVLPVRWGGASKLSSATRGLPAHADWGTIYAFIPRPNEKKSTAVKHVAVYIRYKNARAWCPSMLPFRSYK 6adr C 3.38 BS01 III D 1 P19 D21 T22 V23 P24 N28 V29 R30 T31 P32 P33 P19 D21 T22 V23 P24 N28 V29 R30 T31 P32 P33 30514821 GPIPTAPRENSLMFLSTTPDDTVPAYGNVRTPPVNYLPGEITDLLQLARIPTLMAFGRVDAYVPYVAVPTQFDDKPLISFPITLSDPVYQNTLVGAISSNFANYRGCIQITLTFCGPMMARGKFLLSYSPPNGTQPQTLSEAMQCTYSIWDIGLNSSWTFVIPYISPSDYRETRAITNSVYSADGWFSLHKLTKITLPPDCPQSPCILFFASAGEDYTLRLPVDCNPSYVF 6adr C 3.38 BS02 III D 3 G39 D43 Q46 G39 D43 Q46 30514821 GPIPTAPRENSLMFLSTTPDDTVPAYGNVRTPPVNYLPGEITDLLQLARIPTLMAFGRVDAYVPYVAVPTQFDDKPLISFPITLSDPVYQNTLVGAISSNFANYRGCIQITLTFCGPMMARGKFLLSYSPPNGTQPQTLSEAMQCTYSIWDIGLNSSWTFVIPYISPSDYRETRAITNSVYSADGWFSLHKLTKITLPPDCPQSPCILFFASAGEDYTLRLPVDCNPSYVF 6adr B 3.38 BS01 III D 4 G31 V32 C34 Y36 V37 E38 G20 V21 C23 Y25 V26 E27 30514821 DRVTTQTAGNTAINTQSSLGVLCAYVEDPTKSDPPSSSTDQPTTTFTAIDRWYTGRLNSWTKAVKTFSFQAVPLPGAFLSRQGGLNGGAFTATLHRHFLMKCGWQVQVQCNLTQFHQGALLVAMVPETTLDVKPDGKAKSLQELNEEQWVEMSDDYRTGKNMPFQSLGTYYRPPNWTWGPNFINPYQVTVFPHQILNARTSTSVDINVPYIGETPTQSSETQNSWTLLVMVLVPLDYKEGATTDPEITFSVRPTSPYFNGLRNRYTT 6adr R 3.38 BS01 MG R 1 S52 S54 T118 G151 S17 S19 T83 G116 30514821 SMACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYAVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSC 6ads C 2.84 BS01 III D 1 P19 T22 P24 G27 N28 V29 R30 T31 P32 P33 P18 T21 P23 G26 N27 V28 R29 T30 P31 P32 30514821 PIPTAPRENSLMFLSTTPDDTVPAYGNVRTPPVNYLPGEITDLLQLARIPTLMAFGRAYVPYVAVPTQFDDKPLISFPITLSDPVYQNTLVGAISSNFANYRGCIQITLTFCGPMMARGKFLLSYSPPNGTQPQTLSEAMQCTYSIWDIGLNSSWTFVIPYISPSDYRETRAITNSVYSADGWFSLHKLTKITLPPDCPQSPCILFFASAGEDYTLRLPVDCNPSYVF 6ads B 2.84 BS01 III D 4 L30 G31 V32 L33 C34 Y36 V37 E38 L19 G20 V21 L22 C23 Y25 V26 E27 30514821 DRVTTQTAGNTAINTQSSLGVLCAYVEDPTKSDPPSSSTDQPTTTFTAIDRWYTGRLNSWTKAVKTFSFQAVPLPGAFLSRQGGLNGGAFTATLHRHFLMKCGWQVQVQCNLTQFHQGALLVAMVPETTLDVKEQWVEMSDDYRTGKNMPFQSLGTYYRPPNWTWGPNFINPYQVTVFPHQILNARTSTSVDINVPYIGETPTQSSETQNSWTLLVMVLVPLDYKEGATTDPEITFSVRPTSPYFNGLRNRYTT 6adt A 3.22 BS01 III D 1 K34 F35 D38 R120 D122 V181 N243 K34 F35 D38 R120 D122 V181 N243 30514821 STDNAETGVIEAGNTDTDFSGELAAPGSNHTNVKFLFDRSRLLNVIKVLEKDAVFPRPFPTATGTQQDDGYFCLLTPRPTVASRPATRFGLYVSPSDSGVLANTSLDFNFYSLACFTYFRSDLEVTVVSLEPDLEFAVGWFPSGSEYQASSFVYDQLHVPYHFTGRTPRAFASKGGKVSFVLPWNSVSSVLPVRWGGASKLSSATRGLPAHADWGTIYAFIPRPNEKKSTAVKHVAVYIRYKNARAWCPSMLPFRSYK 6adt C 3.22 BS02 III D 3 D43 Q46 D42 Q45 30514821 PIPTAPRENSLMFLSTTPDDTVPAYGNVRTPPVNYLPGEITDLLQLARIPTLMAFGRAYVPYVAVPTQFDDKPLISFPITLSDPVYQNTLVGAISSNFANYRGCIQITLTFCGPMMARGKFLLSYSPPNGTQPQTLSEAMQCTYSIWDIGLNSSWTFVIPYISPSDYRETRAITNSVYSADGWFSLHKLTKITLPPDCPQSPCILFFASAGEDYTLRLPVDCNPSYVF 6ako C 2.40 BS01 NUC A 1 K72 S76 Y77 I78 N118 S119 H122 R164 K3 S7 Y8 I9 N49 S50 H53 R95 GPKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRR 6ako C 2.40 BS02 NUC B 1 L95 N96 Y99 R121 H122 S125 K132 K142 G143 S144 W146 R163 R166 L26 N27 Y30 R52 H53 S56 K63 K73 G74 S75 W77 R94 R97 GPKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRR 6ako C 2.40 BS03 MG C 1 L124 S125 N127 F130 L55 S56 N58 F61 GPKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRR 6akp C 2.32 BS01 NUC B 1 L95 R121 H122 S125 K132 S144 W146 L26 R52 H53 S56 K63 S70 W72 GPKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDKGSYWTLDPDSYNMFENGSFLRRRRRF 6c7l A 1.91 BS01 ATR A 1 S33 S35 M36 R38 H39 G91 G92 S93 S139 T140 L178 T181 M182 P183 V186 S33 S35 M36 R38 H39 G91 G92 S93 S139 T140 L178 T181 M182 P183 V186 MFWLKTRIIEGEGSLSRLSREVKGHERVLILASGSMKRHGFLSEAEDYVKEAGAEVFSIAGLPAEPSVEVIEEFLPKVREFGPDLLVAMGGGSVIDTTKALKVFYDAPELNFGEIAFIDRFSKPKPVPRLKTLLIAIPSTSGAGSEVSGASVLKKGGVKYNIVTPEIAPDVAILDPRLPRTMPPEVARNSGLDVLVHGIEAYTTKVASPFSDAMAIKAIKTVYRWLPLSVKGDEEARARVHYAATMAGIAFLNARLGLCHAMSHKAAWIGPHGLLNAVFLPYVMEFNASKSDYARRRYAEIARELGFQTAKDLIEVVKELNEMLGVPKLGELVDEETFASKVEEMAEKTYHDGLIAFNPVEPKPEEIKELYLKAYRGE 6cba A 1.13 BS02 AKG A 1 R171 L173 F175 H189 D191 L206 H268 V270 R277 A279 R169 L171 F173 H187 D189 L204 H266 V268 R275 A277 1.13.12.19,1.14.11.34 NLQTFELPTEVTGCAADISLGRALIQAWQKDGIFQIKTDSEQDRKTQEAMAASKQFCKEPLTFKSSCVSDLTYSGYVASGEEVTAGKPDFPEIFTVCKDLSVGDQRVKAGWPCHGPVPWPNNTYQKSMKTFMEELGLAGERLLKLTALGFELPINTFTDLTRDGWHHMRVLRFPPQTSTLSRGIGAHTDYGLLVIAAQDDVGGLYIRPPVEGEKRNRNWLPGESSAGMFEHDEPWTFVTPTPGVWTVFPGDILQFMTGGQLLSTPHKVKLNTRERFACAYFHEPNFEASAYPLFEPSANERIHYGEHFTNMFMRCYPDRITTQRINKENRLAHLEDLKKYSDTRATGS 6cba A 1.13 BS03 GGB A 1 E84 V85 T86 D91 R171 I186 H189 D191 Y192 F283 R316 C317 E82 V83 T84 D89 R169 I184 H187 D189 Y190 F281 R314 C315 1.13.12.19,1.14.11.34 NLQTFELPTEVTGCAADISLGRALIQAWQKDGIFQIKTDSEQDRKTQEAMAASKQFCKEPLTFKSSCVSDLTYSGYVASGEEVTAGKPDFPEIFTVCKDLSVGDQRVKAGWPCHGPVPWPNNTYQKSMKTFMEELGLAGERLLKLTALGFELPINTFTDLTRDGWHHMRVLRFPPQTSTLSRGIGAHTDYGLLVIAAQDDVGGLYIRPPVEGEKRNRNWLPGESSAGMFEHDEPWTFVTPTPGVWTVFPGDILQFMTGGQLLSTPHKVKLNTRERFACAYFHEPNFEASAYPLFEPSANERIHYGEHFTNMFMRCYPDRITTQRINKENRLAHLEDLKKYSDTRATGS 6cbs A 1.85 BS01 ZN A 1 D537 H541 D93 H97 QLKRTTMRILIGLLVQNPELATLVPPLENLDENKLPGLGLFRELVNTCLSQPGLTTGQLLEHYRGTNNAATLEKLSMWDDIADKNIAEQTFTDSLNHMFDSLLELRQEELIARERTHGLSNEERLELWTLNQELAKDDIPF 6ct5 A 1.76 BS01 COA A 1 R48 R56 K75 K78 G79 E80 P81 L91 T92 H93 D114 Y160 K161 F164 R40 R48 K67 K70 G71 E72 P73 L83 T84 H85 D106 Y152 K153 F156 TLVASVLPEDLAYAELYSDPPGLTPLPEEAPLIARSVAKRRNEFITVRHCARIALDQLGVPPAPILKGDKGEPCWPDGMVGSLTHCAGYRGAVVGRRDAVRSVGIDAEPHDVLPNGVLDAISLPAERADMPRTMPAALHWDRILFCAKEATYKAWFPLTKRWLGFEDAHITFETDSTGWTGRFVSRILIDGSTLSGPPLTTLRGRWSVERGLVLTAIVLAG 6ct5 A 1.76 BS02 FD7 A 1 K156 E157 Y160 W170 L171 G172 F173 K148 E149 Y152 W162 L163 G164 F165 TLVASVLPEDLAYAELYSDPPGLTPLPEEAPLIARSVAKRRNEFITVRHCARIALDQLGVPPAPILKGDKGEPCWPDGMVGSLTHCAGYRGAVVGRRDAVRSVGIDAEPHDVLPNGVLDAISLPAERADMPRTMPAALHWDRILFCAKEATYKAWFPLTKRWLGFEDAHITFETDSTGWTGRFVSRILIDGSTLSGPPLTTLRGRWSVERGLVLTAIVLAG 6ct5 A 1.76 BS03 FD7 A 2 V125 I129 F153 V117 I121 F145 TLVASVLPEDLAYAELYSDPPGLTPLPEEAPLIARSVAKRRNEFITVRHCARIALDQLGVPPAPILKGDKGEPCWPDGMVGSLTHCAGYRGAVVGRRDAVRSVGIDAEPHDVLPNGVLDAISLPAERADMPRTMPAALHWDRILFCAKEATYKAWFPLTKRWLGFEDAHITFETDSTGWTGRFVSRILIDGSTLSGPPLTTLRGRWSVERGLVLTAIVLAG 6cul A 2.30 BS01 FGD A 1 P67 R68 G71 K72 D75 P65 R66 G69 K70 D73 KRKLAYIWSLRNAAADKAGQYVPYKGEQRYMKSVLESLVEALNQTALGDAYELVGVIYDDDAELPRDQGKIKDYGFAYRPGQQWFYPADLQVQGKTLNDLLLSVPSTYRRYPRGTPEHVAGKSDFERRLHDTLVELGADVVVLDGLLVILDELVRPGAPFARRIMNIHPGVTREDSPYERRGAYATLDALYGARGEKVVDWATMEKVAVEPLYWTGASFHYVDGEVFHDVLKTEISPDDTILELRWNNFNNSLFPALHEGLALLAEK 6cul C 2.30 BS01 FGD C 1 R68 G71 K72 D75 R66 G69 K70 D73 KRKLAYIWSLRNAAADKAGQYVPYKGEQRYMKSVLESLVEALNQTALGDAYELVGVIYDDDAELPRDQGKIKDYGFAYRPGQQWFYPADLQVQGKTLNDLLLSVPSTYRRYPRGTPEHVAGKSDFERRLHDTLVELGADVVVLDGLLVILDELVRPGAPFARRIMNIHPGVTREDSPYERRGAYATLDALYGARGEKVVDWATMEKVAVEPLYWTGASFHYVDGEVFHDVLKTEISPDDTILELRWNNFNNSLFPALHEGLALLAEK 6cul H 2.30 BS01 FGD H 1 K19 P67 R68 G71 K72 D75 K18 P62 R63 G66 K67 D70 TKRKLAYIWSLRNAAADKAGQYVPYKYMKSVLESLVEALNQTALGDAYELVGVIYDDDAELPRDQGKIKDYGFAYRPGQQWFYPADLQVQGKTLNDLLLSVPSTYRRYPRGTPEHVAGKSDFERRLHDTLVELGADVVVLDGLLVILDELVRPGAPFARRIMNIHPGVTREDSPYERRGAYATLDALYGARGEKVVDWATMEKVAVEPLYWTGASFHYVDDSGEVFHDVLKTEISPDDTILELRWNNFNNSLFPALHEGLALLAEKL 6cuo B 1.73 BS01 FFS B 1 M878 N879 V883 Y884 L886 T889 F890 L901 H905 M301 N302 V306 Y307 L309 T312 F313 L324 H328 30258545 GQMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIANITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR 6cup B 1.83 BS01 FFV B 1 V852 M878 N879 V883 Y884 L886 T889 F890 L901 E902 H905 V275 M301 N302 V306 Y307 L309 T312 F313 L324 E325 H328 30258545 GQMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIANITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR 6cur B 1.73 BS01 FFY B 1 V852 M878 V883 Y884 L886 D887 T889 F890 L901 E902 V275 M301 V306 Y307 L309 D310 T312 F313 L324 E325 30258545 GQMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIANITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR 6dew A 2.00 BS01 FOH A 1 L204 S205 M208 N252 L256 L112 S113 M116 N160 L164 30661980 YESEEQLQHRILTAALEFVPAHGWTAEAIAEGAQSLGLSSAAASMFGKDGSELILHFVTQCNTRLTRVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAMLAAIYNTTELVMMQDSSPDFEDTWRFLENRVNDAMNMGHTA 6dew A 2.00 BS02 FOH A 2 V150 N154 R189 L204 L207 M208 L217 L219 L220 M223 Y251 N252 E255 V58 N62 R97 L112 L115 M116 L125 L127 L128 M131 Y159 N160 E163 30661980 YESEEQLQHRILTAALEFVPAHGWTAEAIAEGAQSLGLSSAAASMFGKDGSELILHFVTQCNTRLTRVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAMLAAIYNTTELVMMQDSSPDFEDTWRFLENRVNDAMNMGHTA 6dew B 2.00 BS01 64Z B 1 V150 N154 R189 M208 S216 L217 L220 M223 Y251 N252 E255 V55 N59 R94 M113 S121 L122 L125 M128 Y156 N157 E160 30661980 EEQLQHRILTAALEFVPAHGWTAEAIAEGAQSLGLSSAAASMFGKDGSELILHFVTQCNTRLTRVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAMLAAIYNTTELVMMQDSSPDFEDTWRFLENRVNDAMNMGHT 6dew B 2.00 BS02 FOH D 1 L204 S205 A249 N252 T253 L109 S110 A154 N157 T158 30661980 EEQLQHRILTAALEFVPAHGWTAEAIAEGAQSLGLSSAAASMFGKDGSELILHFVTQCNTRLTRVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAMLAAIYNTTELVMMQDSSPDFEDTWRFLENRVNDAMNMGHT 6dew D 2.00 BS01 64Z D 1 V150 M208 S216 N252 E255 V56 M114 S122 N158 E161 30661980 SEEQLQHRILTAALEFVPAHGWTAEAIAEGAQSLGLSSAAASMFGKDGSELILHFVTQCNTRLTRVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAMLAAIYNTTELVMMQDSSPDFEDTWRFLENRVNDAMNM 6dew D 2.00 BS02 FOH D 1 S205 M208 S111 M114 30661980 SEEQLQHRILTAALEFVPAHGWTAEAIAEGAQSLGLSSAAASMFGKDGSELILHFVTQCNTRLTRVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAMLAAIYNTTELVMMQDSSPDFEDTWRFLENRVNDAMNM 6dew F 2.00 BS01 64Z A 1 L217 L220 R244 A248 L118 L121 R145 A149 30661980 QHRILTAALEFVPAHGWTAEAIAEGAQSLGLSSAAASMFGKDGSELILHFVTQCNTRLTRVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAMLAAIYNTTELVMMQDSSPDFEDTWRFLENRVNDAMNM 6do0 A 2.80 BS01 JY1 A 1 K22 C89 F93 W96 S97 D100 K18 C79 F83 W86 S87 D90 PKEMLRAQTNVILLNVLKQGDNYVYGIIKQVKEASNGEMELNEATLYTIFDRLEQDGIISSYWGRRKYYRLTEIGHENCRLAFESWSRVDKIIENLEANK 6do0 B 2.80 BS01 JY1 A 1 C89 W96 D100 C86 W93 D97 MGAEIPKEMLRAQTNVILLNVLKQGDNYVYGIIKQVKEASNGEMELNEATLYTIFDRLEQDGIISSYWGGGRRKYYRLTEIGHENCRLAFESWSRVDKIIENLEANK 6dsp A 1.37 BS01 PAV A 1 K29 F35 F36 D110 Q124 D167 Q168 W171 D224 S225 F250 L270 W271 K8 F14 F15 D89 Q103 D146 Q147 W150 D203 S204 F229 L249 W250 VTVTFIPKLTGNAFFESANKGAQKYSEQWGFKVDYEGDANASAASQVSVINKAVQQGTNAICLSSVDAAGVKDALKAAADAGVTVTTWDSDVDPSVRKVMVSQGTPEQLGQMLVQMGYDSLKERGKDPEKDAIKYCWHYSNATVTDQNSWQVEGEKYIKSKYPNWQNVAPDNYYSNQDAEQAISVGESILSAHSDIDLIICNDSTALPGQAQAAQNKGLTAKNVTITGFASPNSMKQYCNDGILTRWGLWDCGIQGAMGCYMAYYIASGNSVKVGDKIEIPTVGTVEVMPNSVLDPKADDSDTSSGVVLLPERTIFTKDNMNNYDF 6e0h B 4.05 BS01 CA B 1 G441 E445 E514 E543 G383 E387 E427 E456 30648972 NHHVDYVIRFNYGDIDTPEAIKKFEVLLLELSEVGLQTEVRQLFVFVRAASKKKLKRAVYQSRVRDWLYGVRNTEPEPASSAKPQSEAERLLVIYHLITVPKPRHGEWKNVDAIFPLHDEETNRQCMREWSKKTFLSTEDLDRIRNTFGEHVGFYFAFLQSYFRFLMFPAAFGFSCWLLLGSFSIIYTVVNCLWCIVFIEYWKRQEEDLSCRWQTKGVSAVHEKRAEFKPEKEVFPATKRMYRQLLQVPFALLAAVALGAIIATCFAIEIFISEVYLKGYLVFIPTILVSALIPTMSAVLLTVATKLNDYENYETQDAYKVALTQKIFVVNFITSYLPIILTAFVYVPFASRIVPYLDVFHSINPDRLRKQVIYFTVTAQIVGFALETIVPFVKQRVFREYKEARFLTRVRNEAELEDYDVTDDLREMCIQFGYLALFSPVWPLVPVSFLINNWVELRSDFFKICVECKRPWPQRADTIGPWLDSLGFLSWVGSITSSALVYMFSNGHPTTIRCWALLLTIFFSEHLYLIVRYAVRSALAKLEPPNTRRERIERFMMRKRYLDTVLFWMRQRGWKESAEVGLSLIT 6e0h B 4.05 BS02 CA B 2 E445 D511 E514 E543 D547 E387 D424 E427 E456 D460 30648972 NHHVDYVIRFNYGDIDTPEAIKKFEVLLLELSEVGLQTEVRQLFVFVRAASKKKLKRAVYQSRVRDWLYGVRNTEPEPASSAKPQSEAERLLVIYHLITVPKPRHGEWKNVDAIFPLHDEETNRQCMREWSKKTFLSTEDLDRIRNTFGEHVGFYFAFLQSYFRFLMFPAAFGFSCWLLLGSFSIIYTVVNCLWCIVFIEYWKRQEEDLSCRWQTKGVSAVHEKRAEFKPEKEVFPATKRMYRQLLQVPFALLAAVALGAIIATCFAIEIFISEVYLKGYLVFIPTILVSALIPTMSAVLLTVATKLNDYENYETQDAYKVALTQKIFVVNFITSYLPIILTAFVYVPFASRIVPYLDVFHSINPDRLRKQVIYFTVTAQIVGFALETIVPFVKQRVFREYKEARFLTRVRNEAELEDYDVTDDLREMCIQFGYLALFSPVWPLVPVSFLINNWVELRSDFFKICVECKRPWPQRADTIGPWLDSLGFLSWVGSITSSALVYMFSNGHPTTIRCWALLLTIFFSEHLYLIVRYAVRSALAKLEPPNTRRERIERFMMRKRYLDTVLFWMRQRGWKESAEVGLSLIT 6e1o B 3.59 BS01 CA B 1 E445 D511 E514 D547 K550 E391 D429 E432 D465 K468 30648972 NHHVDYVIRFNYGDIDTPEAIKKFEVLLLELSEVGLQTEVRQLFVFVRAASKKKLKRAVYQSRVRDWLYGVRNTEPEPASSAKPQSEAERLLVIYHLITVPKITPRHGEWKNVDAIFPLHDEETNRQCMREWSKKTFLSTEDLDRIRNTFGEHVGFYFAFLQSYFRFLMFPAAFGFSCWLLLGSFSIIYTVVNCLWCIVFIEYWKRQEEDLSCRWQTKGVSAVHEKRAEFKPEKEIVFPATKRMYRQLLQVPFALLAAVALGAIIATCFAIEIFISEVYLKGYLVFIPTILVSALIPTMSAVLLTVATKLNDYENYETQDAYKVALTQKIFVVNFITSYLPIILTAFVYVPFASRIVPYLDVFEFSINPDRLRKQVIYFTVTAQIVGFALETIVPFVKQRVFREYKEEARFLTRVRNEAELEDYDVTDDLREMCIQFGYLALFSPVWPLVPVSFLINNWVELRSDFFKICVECKRPWPQRADTIGPWLDSLGFLSWVGSITSSALVYMFSNGHEGPTTIRCWALLLTIFFSEHLYLIVRYAVRSALAKLEPPNTRRERIERFMMRKRYLDTFWMRQRGWKESAEVGLSLIT 6e1o B 3.59 BS02 CA B 2 E445 E514 E543 E391 E432 E461 30648972 NHHVDYVIRFNYGDIDTPEAIKKFEVLLLELSEVGLQTEVRQLFVFVRAASKKKLKRAVYQSRVRDWLYGVRNTEPEPASSAKPQSEAERLLVIYHLITVPKITPRHGEWKNVDAIFPLHDEETNRQCMREWSKKTFLSTEDLDRIRNTFGEHVGFYFAFLQSYFRFLMFPAAFGFSCWLLLGSFSIIYTVVNCLWCIVFIEYWKRQEEDLSCRWQTKGVSAVHEKRAEFKPEKEIVFPATKRMYRQLLQVPFALLAAVALGAIIATCFAIEIFISEVYLKGYLVFIPTILVSALIPTMSAVLLTVATKLNDYENYETQDAYKVALTQKIFVVNFITSYLPIILTAFVYVPFASRIVPYLDVFEFSINPDRLRKQVIYFTVTAQIVGFALETIVPFVKQRVFREYKEEARFLTRVRNEAELEDYDVTDDLREMCIQFGYLALFSPVWPLVPVSFLINNWVELRSDFFKICVECKRPWPQRADTIGPWLDSLGFLSWVGSITSSALVYMFSNGHEGPTTIRCWALLLTIFFSEHLYLIVRYAVRSALAKLEPPNTRRERIERFMMRKRYLDTFWMRQRGWKESAEVGLSLIT 6e1o B 3.59 BS03 8K6 B 1 Y589 S592 A609 F616 Y507 S510 A523 F530 30648972 NHHVDYVIRFNYGDIDTPEAIKKFEVLLLELSEVGLQTEVRQLFVFVRAASKKKLKRAVYQSRVRDWLYGVRNTEPEPASSAKPQSEAERLLVIYHLITVPKITPRHGEWKNVDAIFPLHDEETNRQCMREWSKKTFLSTEDLDRIRNTFGEHVGFYFAFLQSYFRFLMFPAAFGFSCWLLLGSFSIIYTVVNCLWCIVFIEYWKRQEEDLSCRWQTKGVSAVHEKRAEFKPEKEIVFPATKRMYRQLLQVPFALLAAVALGAIIATCFAIEIFISEVYLKGYLVFIPTILVSALIPTMSAVLLTVATKLNDYENYETQDAYKVALTQKIFVVNFITSYLPIILTAFVYVPFASRIVPYLDVFEFSINPDRLRKQVIYFTVTAQIVGFALETIVPFVKQRVFREYKEEARFLTRVRNEAELEDYDVTDDLREMCIQFGYLALFSPVWPLVPVSFLINNWVELRSDFFKICVECKRPWPQRADTIGPWLDSLGFLSWVGSITSSALVYMFSNGHEGPTTIRCWALLLTIFFSEHLYLIVRYAVRSALAKLEPPNTRRERIERFMMRKRYLDTFWMRQRGWKESAEVGLSLIT 6e2a A 2.20 BS01 FMN A 1 G21 G22 M23 Q24 T75 A103 K124 D145 C149 A150 S178 G179 G180 N199 M200 G201 T202 Y277 S288 V292 G20 G21 M22 Q23 T74 A102 K123 D144 C148 A149 S177 G178 G179 N198 M199 G200 T201 Y276 S287 V291 1.13.12.16 30246917 GVFRTRFTETFGVEHPIMQGGMQWVGRAEMAAAVANAGGLATLSALTQPSPEALAAEIARCRELTDRPFGVNLTLLPTQKPVPYAEYRAAIIEAGIRVVETAGNDPGEHIAEFRRHGVKVIHKCTAVRHALKAERLGVDAVSIDGFECAGHPGEDDIPGLVLLPAAANRLRVPIIASGGFADGRGLVAALALGADAINMGTRFLATRECPIHPAVKAAIRAADERSTDLIMRSLRNTARVARNAISQEVLAIEARGGAGYADIAALVSGQRGRQVYQQGDTDLGIWSAGMVQGLIDDEPACAELLRDIVEQARQLVRQRLEGMLAG 6e2a A 2.20 BS02 NAD A 1 Q24 W25 L77 P78 Q80 G151 H152 N237 Y261 V268 G270 S288 Q23 W24 L76 P77 Q79 G150 H151 N236 Y260 V267 G269 S287 1.13.12.16 30246917 GVFRTRFTETFGVEHPIMQGGMQWVGRAEMAAAVANAGGLATLSALTQPSPEALAAEIARCRELTDRPFGVNLTLLPTQKPVPYAEYRAAIIEAGIRVVETAGNDPGEHIAEFRRHGVKVIHKCTAVRHALKAERLGVDAVSIDGFECAGHPGEDDIPGLVLLPAAANRLRVPIIASGGFADGRGLVAALALGADAINMGTRFLATRECPIHPAVKAAIRAADERSTDLIMRSLRNTARVARNAISQEVLAIEARGGAGYADIAALVSGQRGRQVYQQGDTDLGIWSAGMVQGLIDDEPACAELLRDIVEQARQLVRQRLEGMLAG 6e58 A 2.75 BS01 CA A 1 K699 I700 D702 E704 D707 T824 E825 K654 I655 D657 E659 D662 T779 E780 TDQQVGAKLVQEIREGKRGPLYAGYFRTWHDRASTGIDGKQQHPENTMAEVPKEVDILFVFHDHTASDSPFWSELKDSYVHKLHQQGTALVQTIGVNELNGRTGLSKDYPDTPEGNKALAAAIVKAFVTDRGVDGLDIDIEHEFTNKRTPEEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENNPIFKGIAEDLDYLLRQYYGSQGGEAEVDTINSDWNQYQNYIDASQFMIGFSFFEESASKGNLWFDVNEYDPNNPEKGKDIEGTRAKKYAEWQPSTGGLKAGIFSYAIDRDGVAHVPSTYKNRTSTNLQRHEVDNISHTDYTVSRKLKTLMTEDKRYDVIDQKDIPDPALREQIIQQVGQYKGDLERYNKTLVLTGDKIQNLKGLEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKSEDRKLLMTLMEQVSNHQKITVKNTAFENQKPKGYYPQTYDTKEGHYDVDNAEHDILTDFVFGTVTKRNTFIGDEEAFAIYKEGAVDGRQYVSKDYTYEAFRKDYKGYKVHLTASNLGETVTSKVTATTDETYLVDVSDGEKVVHHMKLNIGSGAIMMENLAKGAKVIGTSGDFEQAKKIFDGEKSDRFFTWGQTNWIAFDLGEINLAKEWRLFNAETNTEIKTDSSLNVAKGRLQILKDTTIDLEKMDIKNRKEYLSNDENWTDVAQMDDAKAIFNSKLSNVLSRYWRFCVDGGASSYYPQYTELQILGQR 6e5o Y 3.70 BS01 NUC C 1 M27 F195 Y196 K226 D230 G234 S238 S241 K242 A298 R301 M302 N305 R324 N385 E386 N387 R405 K493 G496 N501 A504 V505 G516 F517 S518 S521 Q527 Y528 G577 A625 N626 R734 A737 S740 R741 A744 R773 G774 M784 T785 R787 T790 K791 M26 F164 Y165 K195 D199 G203 S207 S210 K211 A262 R265 M266 N269 R284 N341 E342 N343 R357 K442 G445 N450 A453 V454 G465 F466 S467 S470 Q476 Y477 G526 A574 N575 R669 A672 S675 R676 A679 R708 G709 M719 T720 R722 T725 K726 EKRINKIRKKLSADNATKPVSRSGPMKTLLVRVMTDDLKKRLEKRRKKPEVMPQVISNNAANNLRMLLDDYTKMKEAILQVYWQEFKDDHVGLMCKFAQPASKKIDQNKLKPEMDEKGYTNYFGRCNVAEHEKLILLAQLKPVKDSDEAVTYSLGKFGQRALDFYSIHVTKESTHPVKPLAQIAGNRYASGPVGKALSDACMGTIASFLSKYQDIIIEHQKVVKGNQKRLESLRENLEYPSVTLPPQPHTKEGVDAYNEVIARVRMWVNLNLWQKLDDAKPLLRLKGFPSFPVVRRENEVDWWNTINEVKKLIDAKRDMGRVFWSGEKRNTILEGYNYLPNENDHKKRENPKKPAKRQFGDLLLYLEKKYWGKVFDEAWERIDKKIAGLTSHIEREEARNAEDAQSKAVLTDWLRAKASFVLERLKEMDEKEFYACEIQLQKWYGDLRGNPFAVEAENRVVDISGFSIGSDGHSIQYRNLLAWKYLENGKREFYLLMNYGKKGRIRFTDGTDIKKSGKWQGLLYGGGKAKVIDLTFDPDDEQLIILPLAFGTRQGREFIWNDLLSLETGLIKLANGRVIEKTIYNKKIGRDEPALFVALTFERREVVDPSNIKPVNLIGVARGENIPAVIALTDPEGCPLRIGEGYKEKQRAIQAAKEVEQRRAGGYSRKFASKSRNLADDMVRNSARDLFYHAVTHDAVLVFANLSRGFGRQGKRTFMTERQYTKMEDWLTAKLAYEGLTSKTYLSKTLAQYTSKTCSNCGFTITYADMDVMLVRLKKTSDGWATTLNNKELKAEYQITYYNRYKRQTVSKWTKGRRDEALFLLKKRFSHRPVQEQFVCLDCGHEVHAAEQAALNIARSWLFLNSNSTEFKSYKSGKQPFVGAWQAFYKRRLKEVWK 6e5o Y 3.70 BS02 NUC D 1 R23 S103 N131 A133 E134 H135 Y196 T201 T205 H206 S221 K226 H524 K552 K553 G554 R557 R673 G674 E675 N676 K712 F775 G776 R777 Y789 L815 A816 Q817 Y818 T819 S820 K821 Q920 F966 R22 S102 N127 A129 E130 H131 Y165 T170 T174 H175 S190 K195 H473 K501 K502 G503 R506 R622 G623 E624 N625 K647 F710 G711 R712 Y724 L750 A751 Q752 Y753 T754 S755 K756 Q835 F881 EKRINKIRKKLSADNATKPVSRSGPMKTLLVRVMTDDLKKRLEKRRKKPEVMPQVISNNAANNLRMLLDDYTKMKEAILQVYWQEFKDDHVGLMCKFAQPASKKIDQNKLKPEMDEKGYTNYFGRCNVAEHEKLILLAQLKPVKDSDEAVTYSLGKFGQRALDFYSIHVTKESTHPVKPLAQIAGNRYASGPVGKALSDACMGTIASFLSKYQDIIIEHQKVVKGNQKRLESLRENLEYPSVTLPPQPHTKEGVDAYNEVIARVRMWVNLNLWQKLDDAKPLLRLKGFPSFPVVRRENEVDWWNTINEVKKLIDAKRDMGRVFWSGEKRNTILEGYNYLPNENDHKKRENPKKPAKRQFGDLLLYLEKKYWGKVFDEAWERIDKKIAGLTSHIEREEARNAEDAQSKAVLTDWLRAKASFVLERLKEMDEKEFYACEIQLQKWYGDLRGNPFAVEAENRVVDISGFSIGSDGHSIQYRNLLAWKYLENGKREFYLLMNYGKKGRIRFTDGTDIKKSGKWQGLLYGGGKAKVIDLTFDPDDEQLIILPLAFGTRQGREFIWNDLLSLETGLIKLANGRVIEKTIYNKKIGRDEPALFVALTFERREVVDPSNIKPVNLIGVARGENIPAVIALTDPEGCPLRIGEGYKEKQRAIQAAKEVEQRRAGGYSRKFASKSRNLADDMVRNSARDLFYHAVTHDAVLVFANLSRGFGRQGKRTFMTERQYTKMEDWLTAKLAYEGLTSKTYLSKTLAQYTSKTCSNCGFTITYADMDVMLVRLKKTSDGWATTLNNKELKAEYQITYYNRYKRQTVSKWTKGRRDEALFLLKKRFSHRPVQEQFVCLDCGHEVHAAEQAALNIARSWLFLNSNSTEFKSYKSGKQPFVGAWQAFYKRRLKEVWK 6e5o Y 3.70 BS03 NUC B 1 R4 I5 N6 K10 M27 K28 T29 L31 R33 L39 R42 L43 R47 K48 P54 T235 S238 K242 L306 G327 F328 P329 S330 P332 R336 Y380 N398 K401 P402 K404 Q406 Y413 K417 E431 R432 K435 K436 L440 H443 E447 D454 Q456 S457 W464 R466 F484 E488 Q492 Y495 R499 N509 K541 R542 E543 L599 F601 G602 T603 R604 Q605 R607 W611 N612 I630 K632 I634 K714 Q726 R727 R728 K739 N742 L743 D746 R749 N750 R753 G779 K780 R781 T782 F783 M784 W795 K799 R3 I4 N5 K9 M26 K27 T28 L30 R32 L38 R41 L42 R46 K47 P53 T204 S207 K211 L270 G287 F288 P289 S290 P292 R296 Y336 N350 K353 P354 K356 Q358 Y365 K369 E380 R381 K384 K385 L389 H392 E396 D403 Q405 S406 W413 R415 F433 E437 Q441 Y444 R448 N458 K490 R491 E492 L548 F550 G551 T552 R553 Q554 R556 W560 N561 I579 K581 I583 K649 Q661 R662 R663 K674 N677 L678 D681 R684 N685 R688 G714 K715 R716 T717 F718 M719 W730 K734 EKRINKIRKKLSADNATKPVSRSGPMKTLLVRVMTDDLKKRLEKRRKKPEVMPQVISNNAANNLRMLLDDYTKMKEAILQVYWQEFKDDHVGLMCKFAQPASKKIDQNKLKPEMDEKGYTNYFGRCNVAEHEKLILLAQLKPVKDSDEAVTYSLGKFGQRALDFYSIHVTKESTHPVKPLAQIAGNRYASGPVGKALSDACMGTIASFLSKYQDIIIEHQKVVKGNQKRLESLRENLEYPSVTLPPQPHTKEGVDAYNEVIARVRMWVNLNLWQKLDDAKPLLRLKGFPSFPVVRRENEVDWWNTINEVKKLIDAKRDMGRVFWSGEKRNTILEGYNYLPNENDHKKRENPKKPAKRQFGDLLLYLEKKYWGKVFDEAWERIDKKIAGLTSHIEREEARNAEDAQSKAVLTDWLRAKASFVLERLKEMDEKEFYACEIQLQKWYGDLRGNPFAVEAENRVVDISGFSIGSDGHSIQYRNLLAWKYLENGKREFYLLMNYGKKGRIRFTDGTDIKKSGKWQGLLYGGGKAKVIDLTFDPDDEQLIILPLAFGTRQGREFIWNDLLSLETGLIKLANGRVIEKTIYNKKIGRDEPALFVALTFERREVVDPSNIKPVNLIGVARGENIPAVIALTDPEGCPLRIGEGYKEKQRAIQAAKEVEQRRAGGYSRKFASKSRNLADDMVRNSARDLFYHAVTHDAVLVFANLSRGFGRQGKRTFMTERQYTKMEDWLTAKLAYEGLTSKTYLSKTLAQYTSKTCSNCGFTITYADMDVMLVRLKKTSDGWATTLNNKELKAEYQITYYNRYKRQTVSKWTKGRRDEALFLLKKRFSHRPVQEQFVCLDCGHEVHAAEQAALNIARSWLFLNSNSTEFKSYKSGKQPFVGAWQAFYKRRLKEVWK 6e79 Y 3.20 BS01 NUC C 1 M27 F195 Y196 K226 D230 G234 S238 S241 K242 A298 R301 M302 N305 R324 E378 G496 G500 N501 A504 V505 G516 F517 S518 Q527 Y528 G577 A625 N626 R734 A737 S740 R741 R773 K780 M784 T785 R787 T790 K791 M26 F164 Y165 K195 D199 G203 S207 S210 K211 A262 R265 M266 N269 R284 E334 G445 G449 N450 A453 V454 G465 F466 S467 Q476 Y477 G526 A574 N575 R669 A672 S675 R676 R708 K715 M719 T720 R722 T725 K726 EKRINKIRKKLSADNATKPVSRSGPMKTLLVRVMTDDLKKRLEKRRKKPEVMPQVISNNAANNLRMLLDDYTKMKEAILQVYWQEFKDDHVGLMCKFAQPASKKIDQNKLKPEMDEKGYTNYFGRCNVAEHEKLILLAQLKPEKDSDEAVTYSLGKFGQRALDFYSIHVTKESTHPVKPLAQIAGNRYASGPVGKALSDACMGTIASFLSKYQDIIIEHQKVVKGNQKRLESLRENLEYPSVTLPPQPHTKEGVDAYNEVIARVRMWVNLNLWQKLDDAKPLLRLKGFPSFPVVRRENEVDWWNTINEVKKLIDAKRDMGRVFWSGEKRNTILEGYNYLPNENDHKKRENPKKPAKRQFGDLLLYLEKKYWGKVFDEAWERIDKKIAGLTSHIEREEARNAEDAQSKAVLTDWLRAKASFVLERLKEMDEKEFYACEIQLQKWYGDLRGNPFAVEAENRVVDISGFSIGSDGHSIQYRNLLAWKYLENGKREFYLLMNYGKKGRIRFTDGTDIKKSGKWQGLLYGGGKAKVIDLTFDPDDEQLIILPLAFGTRQGREFIWNDLLSLETGLIKLANGRVIEKTIYNKKIGRDEPALFVALTFERREVVDPSNIKPVNLIGVARGENIPAVIALTDPEGCPLRIGEGYKEKQRAIQAAKEVEQRRAGGYSRKFASKSRNLADDMVRNSARDLFYHAVTHDAVLVFANLSRGFGRQGKRTFMTERQYTKMEDWLTAKLAYEGLTSKTYLSKTLAQYTSKTCSNCGFTITYDGMLVRLKKTSDGWATTLNNKELKAEYQITYYNRYKRQTVEKESKWTKGRRDEALFLLKKRFSHRPVQEQFVCLDCGHEVHAAEQAALNIARSWLFLNSNSTEFKSYKSGKQPFVGAWQAFYKRRLKEVWK 6e79 Y 3.20 BS02 NUC D 1 R23 E134 H135 Y196 T201 T205 H206 S221 K226 H524 K552 K553 G554 R673 G674 E675 N676 K712 F775 R777 L815 A816 Q817 Y818 T819 K821 I830 A860 E861 Y862 F908 Q920 Y959 R22 E130 H131 Y165 T170 T174 H175 S190 K195 H473 K501 K502 G503 R622 G623 E624 N625 K647 F710 R712 L750 A751 Q752 Y753 T754 K756 I765 A792 E793 Y794 F823 Q835 Y874 EKRINKIRKKLSADNATKPVSRSGPMKTLLVRVMTDDLKKRLEKRRKKPEVMPQVISNNAANNLRMLLDDYTKMKEAILQVYWQEFKDDHVGLMCKFAQPASKKIDQNKLKPEMDEKGYTNYFGRCNVAEHEKLILLAQLKPEKDSDEAVTYSLGKFGQRALDFYSIHVTKESTHPVKPLAQIAGNRYASGPVGKALSDACMGTIASFLSKYQDIIIEHQKVVKGNQKRLESLRENLEYPSVTLPPQPHTKEGVDAYNEVIARVRMWVNLNLWQKLDDAKPLLRLKGFPSFPVVRRENEVDWWNTINEVKKLIDAKRDMGRVFWSGEKRNTILEGYNYLPNENDHKKRENPKKPAKRQFGDLLLYLEKKYWGKVFDEAWERIDKKIAGLTSHIEREEARNAEDAQSKAVLTDWLRAKASFVLERLKEMDEKEFYACEIQLQKWYGDLRGNPFAVEAENRVVDISGFSIGSDGHSIQYRNLLAWKYLENGKREFYLLMNYGKKGRIRFTDGTDIKKSGKWQGLLYGGGKAKVIDLTFDPDDEQLIILPLAFGTRQGREFIWNDLLSLETGLIKLANGRVIEKTIYNKKIGRDEPALFVALTFERREVVDPSNIKPVNLIGVARGENIPAVIALTDPEGCPLRIGEGYKEKQRAIQAAKEVEQRRAGGYSRKFASKSRNLADDMVRNSARDLFYHAVTHDAVLVFANLSRGFGRQGKRTFMTERQYTKMEDWLTAKLAYEGLTSKTYLSKTLAQYTSKTCSNCGFTITYDGMLVRLKKTSDGWATTLNNKELKAEYQITYYNRYKRQTVEKESKWTKGRRDEALFLLKKRFSHRPVQEQFVCLDCGHEVHAAEQAALNIARSWLFLNSNSTEFKSYKSGKQPFVGAWQAFYKRRLKEVWK 6e79 Y 3.20 BS03 NUC B 1 R4 I5 N6 K10 M27 T29 L31 R33 M35 L39 R42 L43 R47 K48 K49 P54 S238 L306 K326 G327 P329 S330 P332 R336 Y380 N398 K401 P402 K404 Q406 Y413 K417 R432 K435 K436 L440 H443 E447 D454 Q456 S457 W464 R466 F484 Y485 E488 Q492 Y495 R499 N509 V511 K541 R542 E543 F544 L599 F601 G602 T603 R604 Q605 R607 W611 R628 I630 K632 I634 K714 Q726 R727 R728 K739 N742 L743 R749 N750 R753 Q778 G779 K780 T782 F783 M784 K799 R3 I4 N5 K9 M26 T28 L30 R32 M34 L38 R41 L42 R46 K47 K48 P53 S207 L270 K286 G287 P289 S290 P292 R296 Y336 N350 K353 P354 K356 Q358 Y365 K369 R381 K384 K385 L389 H392 E396 D403 Q405 S406 W413 R415 F433 Y434 E437 Q441 Y444 R448 N458 V460 K490 R491 E492 F493 L548 F550 G551 T552 R553 Q554 R556 W560 R577 I579 K581 I583 K649 Q661 R662 R663 K674 N677 L678 R684 N685 R688 Q713 G714 K715 T717 F718 M719 K734 EKRINKIRKKLSADNATKPVSRSGPMKTLLVRVMTDDLKKRLEKRRKKPEVMPQVISNNAANNLRMLLDDYTKMKEAILQVYWQEFKDDHVGLMCKFAQPASKKIDQNKLKPEMDEKGYTNYFGRCNVAEHEKLILLAQLKPEKDSDEAVTYSLGKFGQRALDFYSIHVTKESTHPVKPLAQIAGNRYASGPVGKALSDACMGTIASFLSKYQDIIIEHQKVVKGNQKRLESLRENLEYPSVTLPPQPHTKEGVDAYNEVIARVRMWVNLNLWQKLDDAKPLLRLKGFPSFPVVRRENEVDWWNTINEVKKLIDAKRDMGRVFWSGEKRNTILEGYNYLPNENDHKKRENPKKPAKRQFGDLLLYLEKKYWGKVFDEAWERIDKKIAGLTSHIEREEARNAEDAQSKAVLTDWLRAKASFVLERLKEMDEKEFYACEIQLQKWYGDLRGNPFAVEAENRVVDISGFSIGSDGHSIQYRNLLAWKYLENGKREFYLLMNYGKKGRIRFTDGTDIKKSGKWQGLLYGGGKAKVIDLTFDPDDEQLIILPLAFGTRQGREFIWNDLLSLETGLIKLANGRVIEKTIYNKKIGRDEPALFVALTFERREVVDPSNIKPVNLIGVARGENIPAVIALTDPEGCPLRIGEGYKEKQRAIQAAKEVEQRRAGGYSRKFASKSRNLADDMVRNSARDLFYHAVTHDAVLVFANLSRGFGRQGKRTFMTERQYTKMEDWLTAKLAYEGLTSKTYLSKTLAQYTSKTCSNCGFTITYDGMLVRLKKTSDGWATTLNNKELKAEYQITYYNRYKRQTVEKESKWTKGRRDEALFLLKKRFSHRPVQEQFVCLDCGHEVHAAEQAALNIARSWLFLNSNSTEFKSYKSGKQPFVGAWQAFYKRRLKEVWK 6e7a Y 4.20 BS01 NUC B 1 R4 I5 K10 M27 K28 T29 L31 R33 M35 L39 R42 R47 K49 P54 T235 S238 K326 G327 P329 P332 V333 R336 N398 P399 K400 K401 A403 Q406 Y413 K417 E431 R432 K435 K436 L440 H443 R450 D454 Q456 W464 N509 K541 R542 E543 L599 F601 T603 R604 Q605 R607 W611 N612 D613 R628 K637 F647 K714 R728 A729 G730 G731 S733 R734 K735 F736 N742 L743 R749 N750 F783 E786 R787 W795 Y862 E905 A906 F908 L909 R3 I4 K9 M26 K27 T28 L30 R32 M34 L38 R41 R46 K48 P53 T204 S207 K286 G287 P289 P292 V293 R296 N350 P351 K352 K353 A355 Q358 Y365 K369 E380 R381 K384 K385 L389 H392 R399 D403 Q405 W413 N458 K490 R491 E492 L548 F550 T552 R553 Q554 R556 W560 N561 D562 R577 K586 F596 K649 R663 A664 G665 G666 S668 R669 K670 F671 N677 L678 R684 N685 F712 E715 R716 W724 Y788 E814 A815 F817 L818 EKRINKIRKKLSADNATKPVSRSGPMKTLLVRVMTDDLKKRLEKRRKKPEVMPQVISNNAANNLRMLLDDYTKMKEAILQVYWQEFKDDHVGLMCKFAQPASKKIDQNKLKPEMDEKGYTNYFGRCNVAEHEKLILLAQLKPEKDSDEAVTYSLGKFGQRALDFYSIHVTKESTHPVKPLAQIAGNRYASGPVGKALSDACMGTIASFLSKYQDIIIEHQKVVKGNQKRLESLRENLEYPSVTLPPQPHTKEGVDAYNEVIARVRMWVNLNLWQKLDDAKPLLRLKGFPSFPVVERENEVDWWNTINEVKKLIDAKRDMGRVFWSGEKRNTILEGYNYLPNENDHKKRENPKKPAKRQFGDLLLYLEKKYWGKVFDEAWERIDKKIAGLTSHIEREEARNAEDAQSKAVLTDWLRAKASFVLERLKEMDEKEFYACEIQLQKWYGDLRGNPFAVEAENRVVDISGFSIGSDGHSIQYRNLLAWKYLENGKREFYLLMNYGKKGRIRFTDGTDIKKSGKWQGLLYGGGKAKVIDLTFDPDDEQLIILPLAFGTRQGREFIWNDLLSLETGLIKLANGRVIEKTIYNKKIGRDEPALFVALTFERREVVDPSNIKPVNLIGVARGENIPAVIALTDPEGCPLRIGEGYKEKQRAIQAAKEVEQRRAGGYSRKFASKSRNLADDMVRNSARDLFYHAVTHDAVLVFANLSRGFGFMTERQYTKMEDWLTAKLAYEGLTSKTYLSKTLAQYTSKTCSNCGFTITYDGMLVRLKKTSDGWATTLNNKELKAEYQITYYNRYKRQTVEKESKWTKGRRDEALFLLKKRFSHRPVQEQFVCLDCGHEVHAAEQAALNIARSWLFLNSNSTEFKSYKSGKQPFVGAWQAFYKRRLKEVWK 6e7a Y 4.20 BS02 NUC D 1 R23 N131 A133 E134 H135 Y196 T201 K202 T205 H206 S221 K226 H524 R529 K553 G554 R22 N127 A129 E130 H131 Y165 T170 K171 T174 H175 S190 K195 H473 R478 K502 G503 EKRINKIRKKLSADNATKPVSRSGPMKTLLVRVMTDDLKKRLEKRRKKPEVMPQVISNNAANNLRMLLDDYTKMKEAILQVYWQEFKDDHVGLMCKFAQPASKKIDQNKLKPEMDEKGYTNYFGRCNVAEHEKLILLAQLKPEKDSDEAVTYSLGKFGQRALDFYSIHVTKESTHPVKPLAQIAGNRYASGPVGKALSDACMGTIASFLSKYQDIIIEHQKVVKGNQKRLESLRENLEYPSVTLPPQPHTKEGVDAYNEVIARVRMWVNLNLWQKLDDAKPLLRLKGFPSFPVVERENEVDWWNTINEVKKLIDAKRDMGRVFWSGEKRNTILEGYNYLPNENDHKKRENPKKPAKRQFGDLLLYLEKKYWGKVFDEAWERIDKKIAGLTSHIEREEARNAEDAQSKAVLTDWLRAKASFVLERLKEMDEKEFYACEIQLQKWYGDLRGNPFAVEAENRVVDISGFSIGSDGHSIQYRNLLAWKYLENGKREFYLLMNYGKKGRIRFTDGTDIKKSGKWQGLLYGGGKAKVIDLTFDPDDEQLIILPLAFGTRQGREFIWNDLLSLETGLIKLANGRVIEKTIYNKKIGRDEPALFVALTFERREVVDPSNIKPVNLIGVARGENIPAVIALTDPEGCPLRIGEGYKEKQRAIQAAKEVEQRRAGGYSRKFASKSRNLADDMVRNSARDLFYHAVTHDAVLVFANLSRGFGFMTERQYTKMEDWLTAKLAYEGLTSKTYLSKTLAQYTSKTCSNCGFTITYDGMLVRLKKTSDGWATTLNNKELKAEYQITYYNRYKRQTVEKESKWTKGRRDEALFLLKKRFSHRPVQEQFVCLDCGHEVHAAEQAALNIARSWLFLNSNSTEFKSYKSGKQPFVGAWQAFYKRRLKEVWK 6e7a Y 4.20 BS03 NUC C 1 M27 D194 F195 K226 D230 S238 S241 K242 W309 R499 F503 F517 S518 Y528 G577 N626 R628 G674 E675 N676 R741 G776 F783 M784 E786 Q788 K791 Y862 P918 Q920 M26 D163 F164 K195 D199 S207 S210 K211 W273 R448 F452 F466 S467 Y477 G526 N575 R577 G623 E624 N625 R676 G711 F712 M713 E715 Q717 K720 Y788 P827 Q829 EKRINKIRKKLSADNATKPVSRSGPMKTLLVRVMTDDLKKRLEKRRKKPEVMPQVISNNAANNLRMLLDDYTKMKEAILQVYWQEFKDDHVGLMCKFAQPASKKIDQNKLKPEMDEKGYTNYFGRCNVAEHEKLILLAQLKPEKDSDEAVTYSLGKFGQRALDFYSIHVTKESTHPVKPLAQIAGNRYASGPVGKALSDACMGTIASFLSKYQDIIIEHQKVVKGNQKRLESLRENLEYPSVTLPPQPHTKEGVDAYNEVIARVRMWVNLNLWQKLDDAKPLLRLKGFPSFPVVERENEVDWWNTINEVKKLIDAKRDMGRVFWSGEKRNTILEGYNYLPNENDHKKRENPKKPAKRQFGDLLLYLEKKYWGKVFDEAWERIDKKIAGLTSHIEREEARNAEDAQSKAVLTDWLRAKASFVLERLKEMDEKEFYACEIQLQKWYGDLRGNPFAVEAENRVVDISGFSIGSDGHSIQYRNLLAWKYLENGKREFYLLMNYGKKGRIRFTDGTDIKKSGKWQGLLYGGGKAKVIDLTFDPDDEQLIILPLAFGTRQGREFIWNDLLSLETGLIKLANGRVIEKTIYNKKIGRDEPALFVALTFERREVVDPSNIKPVNLIGVARGENIPAVIALTDPEGCPLRIGEGYKEKQRAIQAAKEVEQRRAGGYSRKFASKSRNLADDMVRNSARDLFYHAVTHDAVLVFANLSRGFGFMTERQYTKMEDWLTAKLAYEGLTSKTYLSKTLAQYTSKTCSNCGFTITYDGMLVRLKKTSDGWATTLNNKELKAEYQITYYNRYKRQTVEKESKWTKGRRDEALFLLKKRFSHRPVQEQFVCLDCGHEVHAAEQAALNIARSWLFLNSNSTEFKSYKSGKQPFVGAWQAFYKRRLKEVWK 6ea8 A 2.60 BS01 J2A A 1 A129 V130 Y138 K142 A145 N149 Q169 R182 R184 K186 A130 V131 Y139 K143 A146 N150 Q170 R183 R185 K187 SMAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKYMWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIITYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMNALSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKKGAVLPIP 6ea8 B 2.60 BS01 J2A A 1 H17 A18 F19 R60 I105 H18 A19 F20 R61 I106 SMAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKYMWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIITYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMNALSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKKGAVLPIP 6ea8 F 2.60 BS01 J2A F 1 E14 H17 A18 F19 R60 I105 E14 H17 A18 F19 R60 I105 MAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKYMWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIITYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMNALSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKKGAVLPIP 6ea8 H 2.60 BS01 J2B H 1 L16 H17 A18 F19 R60 I105 L17 H18 A19 F20 R61 I106 SMAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKYMWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIITYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMNALSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKKGAVLPIP 6ea9 A 2.10 BS02 9BG B 1 E14 L16 H17 A18 F19 A27 R60 I105 E15 L17 H18 A19 F20 A28 R61 I106 SMAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKYMWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIITYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMNALSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKKGAVLPIP 6ea9 B 2.10 BS02 9BG B 1 A129 V130 Y138 I141 K142 A145 N149 I167 Q169 R182 R184 K186 A130 V131 Y139 I142 K143 A146 N150 I168 Q170 R183 R185 K187 SMAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKYMWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIITYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMNALSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKKGAVLPIP 6ea9 D 2.10 BS01 9BG C 1 E14 H17 A18 F19 A27 R60 I105 E15 H18 A19 F20 A28 R61 I106 SMAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKYMWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIITYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMNALSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKKGAVLPIP 6edg A 1.47 BS01 P34 A 1 H440 G441 Y470 A478 Y481 Q485 E553 H46 G47 Y76 A84 Y87 Q91 E159 PTGAEFLGDGGDVSFSTRGTQNWTVERLLQAHAQLEERGYVFVGYHGTALEAAQSIVFGGVRARSQDLDAIWRGFYIAGDPALAYGYAQDQEPDARGRIANGALLRVYVPHSSLPGFYRTSLTLAAPEAAGEVERLIGHPLPLRLDAITGPEEEGGREETILGWPLAERTVVIPSAIPTDPRNVGGDLDPSSIPDKEQAISALPDYASQPGKP 6ejw A 1.99 BS01 IAC A 1 R54 I57 T81 R84 G85 R50 I53 T77 R80 G81 SPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLL 6ejw A 1.99 BS02 IAC A 2 S8 A9 S4 A5 SPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLL 6ejw A 1.99 BS03 IAC A 3 R15 H16 R11 H12 SPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLL 6ejw B 1.99 BS02 IAC A 4 P45 R48 E49 P41 R44 E45 SPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLL 6ejw C 1.99 BS01 IAC C 1 R54 T81 R84 G85 R50 T77 R80 G81 SPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLL 6ejw C 1.99 BS02 IAC C 2 A77 G78 I79 A80 T81 R84 A73 G74 I75 A76 T77 R80 SPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLL 6ejw D 1.99 BS02 IAC D 1 R54 I57 R84 G85 R50 I53 R80 G81 SPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLL 6ejz A 1.90 BS01 IAC A 1 R54 I57 T81 R84 G85 Y88 R51 I54 T78 R81 G82 Y85 QSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNYLKAAPVELRQWLEEVLLK 6ejz C 1.90 BS02 IAC C 1 R54 I57 R84 G85 Y88 R51 I54 R81 G82 Y85 QSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNYLKAAPVELRQWLEEVLL 6ejz D 1.90 BS03 IAC D 3 R15 H16 W19 R11 H12 W15 SPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNYLKAAPVELRQWLEEVLL 6elb A 1.44 BS02 IAC B 1 L41 F42 L44 L40 F41 L43 AQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLFLLPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIAMITRGSGYLKAAPVELRQWLEEVLLK 6elb B 1.44 BS02 IAC B 1 R54 I57 V58 M81 R84 Y88 R53 I56 V57 M80 R83 Y87 AQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLFLLPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIAMITRGSGYLKAAPVELRQWLEEVLLK 6elf A 1.83 BS02 IAC B 1 L41 F42 L40 F41 AQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLFLLPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIAIITRGSNYLKAAPVELRQWLEEVLLK 6elf B 1.83 BS01 IAC A 1 L41 L44 L40 L43 AQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLFLLPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIAIITRGSNYLKAAPVELRQWLEEVLL 6elf B 1.83 BS02 IAC B 1 R54 V58 I81 R84 G85 Y88 R53 V57 I80 R83 G84 Y87 AQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLFLLPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIAIITRGSNYLKAAPVELRQWLEEVLL 6elg A 1.38 BS01 3BO A 1 R54 I57 V58 R84 G85 Y88 R53 I56 V57 R83 G84 Y87 AQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLFLLPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIAIITRGSNYLKAAPVELRQWLEEVLLK 6elg B 1.38 BS02 3BO B 1 R54 I57 V58 I81 R84 G85 Y88 R52 I55 V56 I79 R82 G83 Y86 QQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLFLLPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIAIITRGSNYLKAAPVELRQWLEEVLLK 6eni A 1.10 BS01 IAC A 1 R54 I57 T81 R84 Y88 R53 I56 T80 R83 Y87 AQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLLPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNYLKAAPVELRQWLEEVLL 6eni B 1.10 BS02 IAC B 1 R54 I57 R84 Y88 R53 I56 R83 Y87 AQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLLPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNYLKAAPVELRQWLEEVLLK 6ep0 A 2.35 BS01 AMP A 1 K78 F83 N115 H118 E122 G123 N124 G125 R129 Y154 M158 E159 E197 K70 F75 N107 H110 E114 G115 N116 G117 R121 Y146 M150 E151 E189 LENKLGIINQLELNRVEERVSKENAKRLYDSGDIDRIEVGTFKGLSYIHNYLFEDIYEFAGKVRSQNISKGNFRFAPVMYLEIALEHIDKMPQRNLDEIVAKYVEMNIAHPFREGNGRATRIWLDLILKKELKRVVDWNLINKEDYLSAMERSPVKDLEIKYLISNALTDKINDREIFMKGIDISYYYEGYTEYNVDEL 6ep0 A 2.35 BS02 CA A 1 R23 E201 R15 E193 LENKLGIINQLELNRVEERVSKENAKRLYDSGDIDRIEVGTFKGLSYIHNYLFEDIYEFAGKVRSQNISKGNFRFAPVMYLEIALEHIDKMPQRNLDEIVAKYVEMNIAHPFREGNGRATRIWLDLILKKELKRVVDWNLINKEDYLSAMERSPVKDLEIKYLISNALTDKINDREIFMKGIDISYYYEGYTEYNVDEL 6ep0 A 2.35 BS03 CA A 2 N32 R35 D63 N24 R27 D55 LENKLGIINQLELNRVEERVSKENAKRLYDSGDIDRIEVGTFKGLSYIHNYLFEDIYEFAGKVRSQNISKGNFRFAPVMYLEIALEHIDKMPQRNLDEIVAKYVEMNIAHPFREGNGRATRIWLDLILKKELKRVVDWNLINKEDYLSAMERSPVKDLEIKYLISNALTDKINDREIFMKGIDISYYYEGYTEYNVDEL 6ep0 B 2.35 BS02 CA B 1 K78 E122 K72 E116 HMLENKLGIINQLELNRVEERVSKENAKRLYDSGDIDRIEVGTFKGLSYIHNYLFEDIYEFAGKVRSQNISKGNFRFAPVMYLEIALEHIDKMPQRNLDEIVAKYVEMNIAHPFREGNGRATRIWLDLILKKELKRVVDWNLINKEDYLSAMERSPVKDLEIKYLISNALTDKINDREIFMKGIDISYYYEGYTEYNVDEL 6ep2 B 2.15 BS01 ADP B 1 K78 N115 H118 E122 G123 N124 G125 R126 R129 Y154 M158 E159 E197 K73 N110 H113 E117 G118 N119 G120 R121 R124 Y149 M153 E154 E192 HHMLENKLGIINQLELNRVEERVSKENAKRLYDSGDIDRIEVGTFKGLSYIHNYLFEDIYEFAGKVRSQNISKGNFRFAPVMYLEIALEHIDKMPQRNLDEIVAKYVEMNIAHPFREGNGRATRIWLDLILKKELKRVVDWNLINKEDYLSAMERSPVKDLEIKYLISNALTDKINDREIFMKGIDISYYYEGYTEYNVDEL 6ep2 D 2.15 BS01 ADP D 1 K78 F81 F83 N115 H118 E122 G123 N124 G125 R126 R129 Y154 M158 E159 E197 K74 F77 F79 N111 H114 E118 G119 N120 G121 R122 R125 Y150 M154 E155 E193 HHHMLENKLGIINQLELNRVEERVSKENAKRLYDSGDIDRIEVGTFKGLSYIHNYLFEDIYEFAGKVRSQNISKGNFRFAPVMYLEIALEHIDKMPQRNLDEIVAKYVEMNIAHPFREGNGRATRIWLDLILKKELKRVVDWNLINKEDYLSAMERSPVKDLEIKYLISNALTDKINDREIFMKGIDISYYYEGYTEYNVDEL 6epm S 2.50 BS01 BQ5 S 1 M878 V883 Y884 D887 F890 H905 M294 V299 Y300 D303 F306 H321 30683722 EQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEASAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR 6epn S 2.50 BS01 BQ2 S 1 M878 Y884 D887 F890 L901 H905 M294 Y300 D303 F306 L317 H321 30683722 EQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEASAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR 6epo S 2.40 BS01 BPW S 1 M878 N879 L901 H905 E906 E909 M289 N290 L312 H316 E317 E320 30683722 EQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR 6epo S 2.40 BS02 BPW S 2 V852 M878 V883 Y884 L886 T889 F890 L901 V263 M289 V294 Y295 L297 T300 F301 L312 30683722 EQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR 6epp S 2.40 BS01 BOQ S 1 V852 M878 N879 V883 Y884 D887 F890 V265 M291 N292 V296 Y297 D300 F303 30683722 EQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR 6erb A 2.20 BS01 SO4 A 1 G123 N124 G125 R126 E197 G114 N115 G116 R117 E188 ENKLGIINQLELNRVEERVSKENAKRLYDSGDIDRIEVGTFKGLSYIHNYLFEDIYEFAGKVRSQNISKGNFRFAPVMYLEIALEHIDKMPQRNLDEIVAKYVEMNIAAPFREGNGRATRIWLDLILKKELKRVVDWNLINKEDYLSAMERSPVKDLEIKYLISNALTDKINDREIFMKGIDISYYYEGYTEYNVDEL 6erb D 2.20 BS01 SO4 D 1 E122 G123 N124 G125 R126 E197 E113 G114 N115 G116 R117 E188 ENKLGIINQLELNRVEERVSKENAKRLYDSGDIDRIEVGTFKGLSYIHNYLFEDIYEFAGKVRSQNISKGNFRFAPVMYLEIALEHIDKMPQRNLDEIVAKYVEMNIAAPFREGNGRATRIWLDLILKKELKRVVDWNLINKEDYLSAMERSPVKDLEIKYLISNALTDKINDREIFMKGIDISYYYEGYTEYNVDEL 6eu5 A 1.50 BS01 MYA A 1 H2 A3 F4 W5 N69 Y70 V71 I156 F158 L159 C160 V161 R166 E167 K168 R169 L170 A171 P172 T179 V182 W188 Q189 A190 Y192 T193 A194 L198 Y394 H2 A3 F4 W5 N69 Y70 V71 I156 F158 L159 C160 V161 R166 E167 K168 R169 L170 A171 P172 T179 V182 W188 Q189 A190 Y192 T193 A194 L198 Y394 2.3.1.97 AHAFWSTQPVPQTEDETEKIVFAGPMDEPKTVADIPEEPYPIASTFEWWTPNMEAADDIHAIYELLRDNYVEDDDSMFRFNYSEEFLQWALCPPNYIPDWHVAVRRKADKKLLAFIAGVPVTLRMGTPKYMKVKAQEKGEGEEAAKYDEPRHICEINFLCVHKQLREKRLAPILIKEATRRVNRTNVWQAVYTAGVLLPTPYASGQYFHRSLNPEKLVEIRFSGIPAQYQKFQNPMAMLKRNYQLPSAPKNSGLREMKPSDVPQVRRILMNYLDSFDVGPVFSDAEISHYLLPRDGVVFTYVVENDKKVTDFFSFYRIPSTVIGNSNYNLLNAAYVHYYAATSIPLHQLILDLLIVAHSRGFDVCNMVEILDNRSFVEQLKFGAGDGHLRYYFYNWAYPKIKPSQVALVML 6eu5 A 1.50 BS02 BXN A 1 V71 D73 F78 F80 Y82 T193 G195 Y207 H209 F222 S320 L331 Y335 N366 G387 H388 M410 L411 V71 D73 F78 F80 Y82 T193 G195 Y207 H209 F222 S320 L331 Y335 N366 G387 H388 M410 L411 2.3.1.97 AHAFWSTQPVPQTEDETEKIVFAGPMDEPKTVADIPEEPYPIASTFEWWTPNMEAADDIHAIYELLRDNYVEDDDSMFRFNYSEEFLQWALCPPNYIPDWHVAVRRKADKKLLAFIAGVPVTLRMGTPKYMKVKAQEKGEGEEAAKYDEPRHICEINFLCVHKQLREKRLAPILIKEATRRVNRTNVWQAVYTAGVLLPTPYASGQYFHRSLNPEKLVEIRFSGIPAQYQKFQNPMAMLKRNYQLPSAPKNSGLREMKPSDVPQVRRILMNYLDSFDVGPVFSDAEISHYLLPRDGVVFTYVVENDKKVTDFFSFYRIPSTVIGNSNYNLLNAAYVHYYAATSIPLHQLILDLLIVAHSRGFDVCNMVEILDNRSFVEQLKFGAGDGHLRYYFYNWAYPKIKPSQVALVML 6ewf A 1.54 BS02 31A A 1 V81 E82 D83 F88 F90 Y92 Y217 Y326 I328 S330 L341 Y345 N376 M377 V378 M420 L421 V71 E72 D73 F78 F80 Y82 Y207 Y316 I318 S320 L331 Y335 N366 M367 V368 M410 L411 2.3.1.97 AHAFWSTQPVPQTEDETEKIVFAGPMDEPKTVADIPEEPYPIASTFEWWTPNMEAADDIHAIYELLRDNYVEDDDSMFRFNYSEEFLQWALCPPNYIPDWHVAVRRKADKKLLAFIAGVPVTLRMGTPKYMKVKAQEKGEGEEAAKYDEPRHICEINFLCVHKQLREKRLAPILIKEATRRVNRTNVWQAVYTAGVLLPTPYASGQYFHRSLNPEKLVEIRFSGIPAQYQKFQNPMAMLKRNYQLPSAPKNSGLREMKPSDVPQVRRILMNYLDSFDVGPVFSDAEISHYLLPRDGVVFTYVVENDKKVTDFFSFYRIPSTVIGNSNYNLLNAAYVHYYAATSIPLHQLILDLLIVAHSRGFDVCNMVEILDNRSFVEQLKFGAGDGHLRYYFYNWAYPKIKPSQVALVML 6fh2 A 2.70 BS01 AN2 A 1 S27 R29 R31 H92 S95 P96 R126 R177 S179 V180 M181 R208 Y211 G212 Q223 S24 R26 R28 H89 S92 P93 R123 R174 S176 V177 M178 R205 Y208 G209 Q220 2.7.14.1 GKFFNTAVSAWMSQEGPNSDIVLSSRIRLARNIVDFRFPTLFSSEEAKQIVALFERAFVHRPYGEAGRFELLKMSELQPIEKRVLVEKHLISPHLAEDSPFGACLLSENEEISIMINEEDHIRIQCLFPGLQLAEALEAASELDDWIEGHVNYAFDERLGYLTSCPTNVGTGLRASVMMHLPALVLTQQINRIIPAINQLGLVVRGTYGEGSEALGNIFQISNQITLGKSEEDIVADLHTIVEQLIAQERAARQALVKTLGIQLEDKVFRSYGILANCRVIDSKEAAQCLSDVRLGIDLGYIKNVSRNILNELMILTQPGFLQQYAGGVLRPEERDVRRAALIRERLRMETRL 6fjb A 1.85 BS01 AOC A 1 I29 E31 G32 V37 A50 Q103 D104 L105 M106 D109 K112 I20 E22 G23 V28 A41 Q94 D95 L96 M97 D100 K103 2.7.11.24 PEMVRQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFLPKEKLKELIFEETARFQP 6fjo A 1.17 BS01 GLU A 1 K215 P285 T367 Q368 K30 P100 T182 Q183 RRTLWTTPDTSPNCKMSTEKDSKLTLTLTKCGSQVLGNVSLLAVTGEYHQMTATTKKDVKISLLFDENGILLPSSSLSKDYWNYRSDDSIVSQKYNNAVPFMPNLTAYPKPSAQNAKNYSRTKIISNVYLGALTYQPVIITIAFNQETENGCAYSITFTFTWQKDYSAQQFDVTSFTFSYLTQ 6fjt H 1.27 BS01 III L 1 E23 I24 G25 M26 P28 W29 F114 S115 D116 Y117 H119 P120 V121 C122 G133 Y134 K135 G136 R137 N159 Y184A M201 K202 P204 N204B N205 R206 W207 E8 I9 G10 M11 P13 W14 F111 S112 D113 Y114 H116 P117 V118 C119 G133 Y134 K135 G136 R137 N157 Y183 M204 K205 P207 N209 N210 R211 W212 3.4.21.5 IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG 6fjw A 2.70 BS01 CA A 1 E221 L238 E220 L237 MKKLVFTFKRIDHPAQDLAVKFHGFLMEQLDSDYVDYLHQQQTNPYATKVIQGKENTQWVVHLLTDDHEDKVFMTLLQIKEVSLNDLPKLSVEKVEIQELGADKLLEIFNSEENQTYFSIIFETPTGFKSQGSYVIFPSMRLIFQSLMQKYGRLVENQPEIEEDTLDYLSEHSTITNYRLETSYFRVRQRIPAFRGKLTFKVQGAKTLKAYVKMLLTFGEYSGLGMKTSLGMGGIKLEE 6fjz A 1.86 BS01 DKW A 1 I29 G30 E31 G32 V37 A50 Q103 D104 L105 M106 D109 K112 I21 G22 E23 G24 V29 A42 Q95 D96 L97 M98 D101 K104 2.7.11.24 PEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 6fl1 A 1.60 BS01 NUC B 1 E2 E5 K57 H72 R74 M75 R109 K129 Q163 G170 N171 I172 S217 I219 Y238 K254 K256 R260 G261 E2 E5 K57 H72 R74 M75 R109 K129 Q163 G170 N171 I172 S217 I219 Y238 K254 K256 R260 G261 3.2.2.23,4.2.99.18 PELPEVETVRRELEKRIVGQKIISIEATYPRMVLTGFEQLKKELTGKTIQGISRRGKYLIFEIGDDFRLISHLRMEGKYRLATLDAPREKHDHLTMKFADGQLIYADVRKFGTWELISTDQVLPYFLKKKIGPEPTYEDFDEKLFREKLRKSTKKIKPYLLEQTLVAGLGNIYVDEVLWLAKIHPEKETNQLIESSIHLLHDSIIEILQKAIKLGGSSIRPYSALGSTGKMQNELQVYGKTGEKCSRCGAEIQKIKVAGRGTHFCPVCQQK 6fl4 A 1.60 BS03 8DG A 1 A11 V13 R27 L38 G40 G41 H42 E56 E60 N76 F78 Y87 S89 K110 F127 A6 V8 R22 L33 G35 G36 H37 E51 E55 N71 F73 Y82 S84 K105 F122 3.6.1.55,3.6.1.67,3.6.1.22 AIPRVAVVVFILNGNSILLGRRRSSIGNSTFALPGGHLEFGESFEECAAREVMEETGLKIEKMKLLTVTNNVFKEAPTPSHYVSVSIRAVLVDPSQEPKNMEPEKCEGWDWYDWENLPKPLFWPLEKLFGSGFNPFTH 6fl4 B 1.60 BS03 8DG B 1 A11 V13 R27 A37 L38 G40 G41 H42 E56 E60 N76 Y87 S89 K110 F127 P129 A6 V8 R22 A32 L33 G35 G36 H37 E51 E55 N71 Y82 S84 K105 F122 P124 3.6.1.55,3.6.1.67,3.6.1.22 AIPRVAVVVFILNGNSILLGRRRSSIGNSTFALPGGHLEFGESFEECAAREVMEETGLKIEKMKLLTVTNNVFKEAPTPSHYVSVSIRAVLVDPSQEPKNMEPEKCEGWDWYDWENLPKPLFWPLEKLFGSGFNPFTH 6fle A 1.48 BS01 DQ2 A 1 I29 G30 E31 V37 A50 K52 Q103 D104 L105 M106 D109 K112 K149 S151 N152 L154 C164 D165 I21 G22 E23 V29 A42 K44 Q95 D96 L97 M98 D101 K104 K141 S143 N144 L146 C156 D157 2.7.11.24 PEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFLDDLPKEKLKELIFEETARFQ 6flu A 1.78 BS03 DTK A 3 N218 G219 I220 G241 A242 D243 W247 W262 N196 G197 I198 G219 A220 D221 W225 W240 TSSTIALSEIVSVVNTSDGRLEVFGVGTDKAVWHNRQMAPHTGSPWSGWSSLKGQVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGVITSNPAIYANTDGRLEVFARGADNALWHISQTTAHSGPWSSWASLNGVITSNPTVHINSDGRLEVFARGTDNALWHIWQTAPDSNLWSSWESLNGIITSDPVVIDTADGRLEVFARGADNALWHIWQTISHSGPWSGWQSLNGVITSAPAVAKNCDNRLEAFARGTDNALWHTWQTVSHSGPWSSWQSLNGVITSAPTAVRDADGRLEVFARGTDNALWLTWQTASSWSPWISLGGVLIDASAIK 6flu A 1.78 BS06 DTK A 6 G49 T50 W55 G360 V361 L362 G27 T28 W33 G338 V339 L340 TSSTIALSEIVSVVNTSDGRLEVFGVGTDKAVWHNRQMAPHTGSPWSGWSSLKGQVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGVITSNPAIYANTDGRLEVFARGADNALWHISQTTAHSGPWSSWASLNGVITSNPTVHINSDGRLEVFARGTDNALWHIWQTAPDSNLWSSWESLNGIITSDPVVIDTADGRLEVFARGADNALWHIWQTISHSGPWSGWQSLNGVITSAPAVAKNCDNRLEAFARGTDNALWHTWQTVSHSGPWSSWQSLNGVITSAPTAVRDADGRLEVFARGTDNALWLTWQTASSWSPWISLGGVLIDASAIK 6flv A 1.91 BS01 DTW A 1 G30 V37 A50 D104 M106 D109 K112 S151 N152 L154 C164 G22 V29 A42 D96 M98 D101 K104 S143 N144 L146 C156 2.7.11.24 PEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMLDDLPKEKLKELIFEETARFQP 6frw A 1.52 BS01 ZN A 1 D140 E141 D136 E137 2.4.1.10 30660564 NYKPTPWTRADALKVHSDDPTTTQPLVDVAFPVMSEEVFIWDTMPLRDFDGDIVSVNGWCVIFTLTADRNTNNPDFQDENGNYDIKRDWEDRHGRARICYWYSRTGKDWIFGGRVMAEGVSPTTREWAGTPILLNDEGDIDLYYTCVTPGATIAKVRGKIVTSDEGVSLEGFQHVKSLFSADGKIYQTEEQNAYWNFRDPSPFIDKNDGKLYMLFEGNVAGSRGTHEITQEDMGSVPPGYENVGGARYQVGCIGLAVAKDLSGDEWEILPPLITAVGVNDQTERPHFVFQEGKYYLFTISHKYTFADNLTGPDGVYGFVSNQLTGPYTPMNSSGLVLGNPSSQPFQTYSHYVMPNGLVTSFIDSVPWEGEKFRIGGTEAPTVKILLKGDRSFVVDSFDYGYIPAMKDIILK 6frw A 1.52 BS02 ZN A 2 D52 D54 D56 D48 D50 D52 2.4.1.10 30660564 NYKPTPWTRADALKVHSDDPTTTQPLVDVAFPVMSEEVFIWDTMPLRDFDGDIVSVNGWCVIFTLTADRNTNNPDFQDENGNYDIKRDWEDRHGRARICYWYSRTGKDWIFGGRVMAEGVSPTTREWAGTPILLNDEGDIDLYYTCVTPGATIAKVRGKIVTSDEGVSLEGFQHVKSLFSADGKIYQTEEQNAYWNFRDPSPFIDKNDGKLYMLFEGNVAGSRGTHEITQEDMGSVPPGYENVGGARYQVGCIGLAVAKDLSGDEWEILPPLITAVGVNDQTERPHFVFQEGKYYLFTISHKYTFADNLTGPDGVYGFVSNQLTGPYTPMNSSGLVLGNPSSQPFQTYSHYVMPNGLVTSFIDSVPWEGEKFRIGGTEAPTVKILLKGDRSFVVDSFDYGYIPAMKDIILK 6frw A 1.52 BS03 ZN A 3 H305 D317 H301 D313 2.4.1.10 30660564 NYKPTPWTRADALKVHSDDPTTTQPLVDVAFPVMSEEVFIWDTMPLRDFDGDIVSVNGWCVIFTLTADRNTNNPDFQDENGNYDIKRDWEDRHGRARICYWYSRTGKDWIFGGRVMAEGVSPTTREWAGTPILLNDEGDIDLYYTCVTPGATIAKVRGKIVTSDEGVSLEGFQHVKSLFSADGKIYQTEEQNAYWNFRDPSPFIDKNDGKLYMLFEGNVAGSRGTHEITQEDMGSVPPGYENVGGARYQVGCIGLAVAKDLSGDEWEILPPLITAVGVNDQTERPHFVFQEGKYYLFTISHKYTFADNLTGPDGVYGFVSNQLTGPYTPMNSSGLVLGNPSSQPFQTYSHYVMPNGLVTSFIDSVPWEGEKFRIGGTEAPTVKILLKGDRSFVVDSFDYGYIPAMKDIILK 6g1l A 2.40 BS01 NUC B 1 R203 K206 H209 N210 E213 R217 F218 N221 N242 K243 R4 K7 H10 N11 E14 R18 F19 N22 N43 K44 AKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKDLENRQKKLEHAN 6ghx A 1.16 BS05 ILE A 1 N112 A113 L133 H142 E143 L202 R203 H231 N112 A113 L133 H142 E143 L202 R203 H231 3.4.24.27 30403288 ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK 6god A 1.71 BS02 GNP A 1 G12 G13 V14 G15 K16 S17 A18 F28 V29 D30 E31 Y32 P34 T35 G60 N116 K117 D119 S145 A146 K147 G12 G13 V14 G15 K16 S17 A18 F28 V29 D30 E31 Y32 P34 T35 G60 N116 K117 D119 S145 A146 K147 30683716 STEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSK 6gof A 1.98 BS03 MG A 2 G10 A59 G60 R68 Y96 G10 A59 G60 R68 Y96 30683716 STEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSK 6gom A 1.63 BS03 F6E A 1 K5 L6 V7 S39 Y40 D54 I55 L56 Y71 T74 G75 K8 L9 V10 S42 Y43 D57 I58 L59 Y74 T77 G78 30683716 FQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKE 6gom C 1.63 BS01 GNP C 1 G13 V14 G15 K16 S17 A18 F28 V29 D30 E31 Y32 G60 N116 K117 D119 L120 S145 A146 G17 V18 G19 K20 S21 A22 F32 V33 D34 E35 Y36 G60 N109 K110 D112 L113 S138 A139 30683716 AFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDDSYRKQVVIDGETCLLDILDTAGRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHE 6gqt B 1.69 BS03 F8N B 1 K5 L6 V7 S39 Y40 R41 D54 I55 Y71 T74 K8 L9 V10 S42 Y43 R44 D57 I58 Y74 T77 30683716 FQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKE 6gqt F 1.69 BS01 GNP F 1 G13 V14 G15 K16 S17 A18 F28 V29 D30 G60 N116 K117 D119 L120 S145 A146 G16 V17 G18 K19 S20 A21 F31 V32 D33 G57 N107 K108 D110 L111 S136 A137 30683716 FQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEDSYRKQVVIDGETCLLDILDTAGMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK 6gqw A 2.80 BS03 F8T A 1 L6 V7 S39 Y40 R41 D54 I55 L56 Y71 T74 L9 V10 S42 Y43 R44 D57 I58 L59 Y74 T77 30683716 FQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK 6gqw E 2.80 BS02 GNP E 1 G12 G13 V14 G15 K16 S17 A18 F28 V29 D30 Y32 P34 G60 N116 K117 D119 L120 S145 A146 G16 G17 V18 G19 K20 S21 A22 F32 V33 D34 Y36 P38 G62 N111 K112 D114 L115 S140 A141 30683716 YFQGMTEYKLVVVGAGGVGKSALVIQLIQNHFVDEYDPEDSYRKQVVIDGETCLLDILDTAGRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK 6gqw F 2.80 BS03 F8T F 1 V7 S39 Y40 R41 D54 I55 L56 Y71 T74 V11 S42 Y43 R44 D57 I58 L59 Y69 T72 30683716 YFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTEDSYRKQVVIDGETCLLDILDTAGAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK 6gqx D 2.20 BS01 GNP D 1 G12 G13 G15 K16 S17 A18 F28 V29 D30 E31 T58 G60 N116 K117 D119 L120 S145 A146 G15 G16 G18 K19 S20 A21 F31 V32 D33 E34 T55 G57 N107 K108 D110 L111 S136 A137 30683716 FQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEDSYRKQVVIDGETCLLDILDTAGMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK 6gqx E 2.20 BS01 GNP E 1 G12 G13 V14 G15 K16 S17 A18 F28 V29 D30 A59 N116 K117 D119 L120 S145 A146 G15 G16 V17 G18 K19 S20 A21 F31 V32 D33 A56 N108 K109 D111 L112 S137 A138 30683716 FQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEDSYRKQVVIDGETCLLDILDTASAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK 6gqy A 2.75 BS03 F8Q A 1 K5 L6 V7 S39 Y40 R41 D54 Y71 T74 K9 L10 V11 S43 Y44 R45 D58 Y75 T78 30683716 YFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK 6gqy C 2.75 BS02 GNP C 1 G12 G13 G15 K16 S17 A18 F28 V29 D30 Y32 T35 G60 N116 K117 D119 L120 S145 A146 K147 G16 G17 G19 K20 S21 A22 F32 V33 D34 Y36 T39 G64 N114 K115 D117 L118 S143 A144 K145 30683716 YFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK 6gqy D 2.75 BS03 F8Q D 1 K5 S39 R41 D54 L56 Y71 T74 K9 S43 R45 D58 L60 Y68 T71 30683716 YFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK 6gqy E 2.75 BS02 GNP E 1 G12 G13 V14 G15 K16 S17 A18 F28 V29 D30 Y32 T35 G60 N116 K117 D119 L120 S145 A146 K147 G16 G17 V18 G19 K20 S21 A22 F32 V33 D34 Y36 T39 G64 N113 K114 D116 L117 S142 A143 K144 30683716 YFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK 6gy0 A 2.55 BS01 FGE A 1 M752 P758 W760 I777 K779 Y813 I825 E826 V828 S831 M900 I910 D911 M556 P562 W564 I581 K583 Y617 I629 E630 V632 S635 M704 I714 D715 2.7.1.153 VKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWLQYSFPLQLEPNRALLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQQPEEYALQVNGRHEYLYGNYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNLWSLEQPFSIELIEGRKVNAMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFALYAVVDCPIAWANLMLFDYKDQLKTGERCLYMWPSVLLNPAGTVRGNPNTESAAALVIYLPEVAPVYFPALEKILELLREILERELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFRVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESW 6h7d A 2.40 BS01 BGC A 1 Q177 T181 I184 Q295 Q296 N301 N332 G406 W410 Q157 T161 I164 Q275 Q276 N281 N312 G386 W390 30679446 VTAFVIMTCIVAAMGGLLFGYDLGISGGVTSMEEFLTKFFPQVESQMKKAKHDTAYCKFDNQMLQLFTSSLYLAALVASFMASVITRKHGRKVSMFIGGLAFLIGALFNAFAVNVSMLIIGRLLLGVGVGFANQSTPVYLSEMAPAKIRGALNIGFQMAITIGILVANLINYGTSKMAQHGWRVSLGLAAVPAVVMVIGSFILPDTPNSMLERGKNEEAKQMLKKIRGADNVDHEFQDLIDAVEAAKKVENPWKNIMESKYRPALIFCSAIPFFQQITGINVIMFYAPVLFKTLGFGDDAALMSAVITGVVNMLSTFVSIYAVDRYGRRLLFLEGGIQMFICQLLVGSFIGARFGTSGTGTLTPATADWILAFICVYVAGFAWSWGPLGWLVPSEICPLEIRPAGQAINVSVNMFFTFLIGQFFLTMLCHMKFGLFYFFASMVAIMTVFIYFLLPETKGVPIEEMGRVWKQHWFWKKYIPEDAIIGG 6hlb A 2.00 BS01 III B 1 D154 D191 N192 L227 V231 T232 E236 S253 W254 G255 P256 E257 D258 D264 G265 A292 D306 Y308 T367 S368 D46 D83 N84 L119 V123 T124 E128 S145 W146 G147 P148 E149 D150 D156 G157 A184 D198 Y200 T259 S260 3.4.21.75 30680958 VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAS 6hld A 2.10 BS01 III B 1 D154 D191 L227 G229 V231 T232 E236 S253 W254 G255 P256 E257 D258 D264 G265 A292 G294 D306 Y308 T367 S368 D46 D83 L119 G121 V123 T124 E128 S145 W146 G147 P148 E149 D150 D156 G157 A184 G186 D198 Y200 T259 S260 3.4.21.75 30680958 VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASGSLVP 6hle A 1.99 BS05 GEB B 1 D191 N192 L227 D228 D83 N84 L119 D120 3.4.21.75 30680958 VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASGSLVPR 6hom A 2.10 BS01 III B 1 R46 T83 A84 H85 S87 N88 C91 N92 A95 R130 P131 Y134 L137 T138 G141 K148 L177 T180 V181 F184 K188 R34 T71 A72 H73 S75 N76 C79 N80 A83 R118 P119 Y122 L125 T126 G129 K136 L165 T168 V169 F172 K176 30692204 GPHMLEREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQE 6hom C 2.10 BS01 III D 1 S43 R46 T83 A84 H85 Q86 S87 N88 C91 N92 A95 R130 P131 Y134 L137 T138 K148 L177 T180 V181 F184 Q187 K188 R227 K230 H231 W275 S29 R32 T69 A70 H71 Q72 S73 N74 C77 N78 A81 R116 P117 Y120 L123 T124 K134 L163 T166 V167 F170 Q173 K174 R213 K216 H217 W261 30692204 HMLEREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQE 6hon A 2.20 BS01 III B 1 R46 T83 A84 H85 S87 N88 C91 N92 R130 P131 Y134 L137 T138 K148 L177 T180 V181 F184 R227 K230 H231 R32 T69 A70 H71 S73 N74 C77 N78 R116 P117 Y120 L123 T124 K134 L163 T166 V167 F170 R213 K216 H217 30692204 HMLEREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQE 6hon C 2.20 BS01 III D 1 S43 R46 T83 A84 H85 N88 C91 N92 A95 R130 P131 Y134 L137 T138 L177 T180 V181 F184 K188 R227 K230 H231 S29 R32 T69 A70 H71 N74 C77 N78 A81 R116 P117 Y120 L123 T124 L163 T166 V167 F170 K174 R213 K216 H217 30692204 HMLEREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQE 6hza A 1.90 BS01 III B 1 D154 D191 N192 H194 L227 V231 T232 D233 E236 S253 W254 G255 P256 D258 D264 G265 A292 G294 N295 D306 Y308 T309 T367 S368 D46 D83 N84 H86 L119 V123 T124 D125 E128 S145 W146 G147 P148 D150 D156 G157 A184 G186 N187 D198 Y200 T201 T259 S260 3.4.21.75 30680958 VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASGSLVPR 6hzb A 1.90 BS01 III B 1 D154 D191 N192 L227 V231 T232 E236 S253 W254 G255 P256 D258 D264 G265 A292 N295 D306 Y308 T309 T367 S368 D46 D83 N84 L119 V123 T124 E128 S145 W146 G147 P148 D150 D156 G157 A184 N187 D198 Y200 T201 T259 S260 3.4.21.75 30680958 VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASGSLVPR 6hzc A 1.90 BS05 PTD B 1 D191 N192 L227 D83 N84 L119 3.4.21.75 30680958 VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASGSLVPR 6hzd A 1.90 BS01 III B 1 D154 D191 N192 H194 L227 G229 V231 T232 E236 S253 W254 G255 P256 D258 D264 G265 A292 G294 N295 D306 Y308 T309 T367 S368 D46 D83 N84 H86 L119 G121 V123 T124 E128 S145 W146 G147 P148 D150 D156 G157 A184 G186 N187 D198 Y200 T201 T259 S260 3.4.21.75 30680958 VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASGSLVPR 6iam A 1.51 BS01 III B 1 A47 S49 A65 G89 I90 S91 D92 D107 Y131 F133 C134 F149 S175 Y191 P216 K259 Y260 C261 F263 I305 L321 A19 S21 A37 G61 I62 S63 D64 D79 Y103 F105 C106 F121 S147 Y163 P188 K231 Y232 C233 F235 I277 L293 30675988 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 6iam A 1.51 BS02 III C 1 A201 S202 A173 S174 30675988 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 6id4 A 2.40 BS01 III U 1 Y7 Y9 M45 E63 N66 V67 Q70 V76 D77 T80 Y84 Y99 D116 T143 K146 W147 A152 Q155 Q156 Y159 R163 W167 Y171 Y7 Y9 M45 E63 N66 V67 Q70 V76 D77 T80 Y84 Y99 D116 T143 K146 W147 A152 Q155 Q156 Y159 R163 W167 Y171 GSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHAAEQQRAYLEGRCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW 6iey B 2.10 BS01 CLM A 1 F34 A38 F34 A38 3.1.1.1 30645605 MPLNPHVEALLQMMAQMPAPDFSVANPAEIRAVFDNLAAPPQVARVENIAISLDGRDLDARLYVPEDADERPALMVYYHGGGWVIGTLDTHDGTCRALAQKSGCAVLSIAYRLAPEYRYPAPAEDCYDALVWAKQNAATLGVDGDRLAVGGDAAGGNLAAAVAIMARDRNGPALRHQLLIYPVTDNDFTLASYAENGGGEYYLSTDGMRWFWGHYLGDTAAENAPLAAVLNVADLSGLAPATVITAEYDPLRDEGIAYAKKLDAAGVPVDAATAPGMIHGFFSMFEAVPDSWEWIERGASNLKRDLALE 6iey A 2.10 BS01 CLM A 1 I85 H91 D152 Y181 Y202 L203 H279 G280 S283 I78 H84 D145 Y174 Y195 L196 H272 G273 S276 3.1.1.1 30645605 MPLNPHVEALLQMMAQMPAPAEIRAVFDNLAAPPQVARVENIAISLDGRDLDARLYVPEDADERPALMVYYHGGGWVIGTLDTHDGTCRALAQKSGCAVLSIAYRLAPEYRYPAPAEDCYDALVWAKQNAATLGVDGDRLAVGGDAAGGNLAAAVAIMARDRNGPALRHQLLIYPVTDNDFTLASYAENGGGEYYLSTDGMRWFWGHYLGDTAAENAPLAAVLNVADLSGLAPATVITAEYDPLRDEGIAYAKKLDAAGVPVDAATAPGMIHGFFSMFEAVPDSWEWIERGASNLKRDLALEHHHHH 6ihd A 2.30 BS01 NAD A 1 G10 K11 I12 Y32 D33 I34 I35 S77 A78 I98 V118 A119 N120 T218 G9 K10 I11 Y31 D32 I33 I34 S76 A77 I91 V111 A112 N113 T211 1.1.1.37 30638660 AKVGFIGAGKIGQTIAYSALVSGAVDEAVIYDIIPELPDKFEHELRHAFATKGIKANVLGTNSLDDVSGMDIVVISAGKPRRDLFVDNAKIMIDLAQKLPSKNPGAIYLMVANPVDMMASVFMKYSKQFTISAGDQVETMRMRSFIAKKLKIPVTSVDGFVGGEHGEDAVVLWSTVKIKGKPVDEFNINKDEVSDYVKKIPGEIIRVIGGTTWGPGTIIADIIKSIAFSENRVMSIATPKEYEKEIIHVSAPTVVGSSIGPSLESLLDEKDRWHLNSAMKDFYEAYKENLKQLEQATKA 6ihd B 2.30 BS01 NAD B 1 G10 K11 I12 Y32 D33 I34 I35 S77 A78 K80 P81 R82 I98 V118 A119 N120 T218 P222 G9 K10 I11 Y31 D32 I33 I34 S76 A77 K79 P80 R81 I97 V117 A118 N119 T217 P221 1.1.1.37 30638660 AKVGFIGAGKIGQTIAYSALVSGAVDEAVIYDIIPELPDKFEHELRHAFATKGIKANVLGTNSLDDVSGMDIVVISAGKPRKPGMSRRDLFVDNAKIMIDLAQKLPSKNPGAIYLMVANPVDMMASVFMKYSKQFTISAGDQVETMRMRSFIAKKLKIPVTSVDGFVGGEHGEDAVVLWSTVKIKGKPVDEFNINKDEVSDYVKKIPGEIIRVIGGTTWGPGTIIADIIKSIAFSENRVMSIATPKEYEKEIIHVSAPTVVGSSIGPSLESLLDEKDRWHLNSAMKDFYEAYKENLKQLEQATK 6ihe A 1.90 BS01 NAD A 1 G10 K11 I12 Y32 D33 I34 I35 S77 A78 G79 K80 P81 I98 V118 N120 V144 T218 P222 G9 K10 I11 Y31 D32 I33 I34 S76 A77 G78 K79 P80 I97 V117 N119 V143 T217 P221 1.1.1.37 30638660 AKVGFIGAGKIGQTIAYSALVSGAVDEAVIYDIIPELPDKFEHELRHAFATKGIKANVLGTNSLDDVSGMDIVVISAGKPRKPGMSRRDLFVDNAKIMIDLAQKLPSKNPGAIYLMVANPVDMMASVFMKYSKQFTISAGDQVETMRMRSFIAKKLKIPVTSVDGFVGGEHGEDAVVLWSTVKIKGKPVDEFNINKDEVSDYVKKIPGEIIRVIGGTTWGPGTIIADIIKSIAFSENRVMSIATPKEYEKEIIHVSAPTVVGSSIGPSLESLLDEKDRWHLNSAMKDFYEAYKENLKQLEQAT 6ihe A 1.90 BS02 MLT A 1 R82 R88 N120 R148 P208 I212 T218 R81 R87 N119 R147 P207 I211 T217 1.1.1.37 30638660 AKVGFIGAGKIGQTIAYSALVSGAVDEAVIYDIIPELPDKFEHELRHAFATKGIKANVLGTNSLDDVSGMDIVVISAGKPRKPGMSRRDLFVDNAKIMIDLAQKLPSKNPGAIYLMVANPVDMMASVFMKYSKQFTISAGDQVETMRMRSFIAKKLKIPVTSVDGFVGGEHGEDAVVLWSTVKIKGKPVDEFNINKDEVSDYVKKIPGEIIRVIGGTTWGPGTIIADIIKSIAFSENRVMSIATPKEYEKEIIHVSAPTVVGSSIGPSLESLLDEKDRWHLNSAMKDFYEAYKENLKQLEQAT 6ihe B 1.90 BS01 NAD B 1 G10 K11 I12 Y32 D33 I34 I35 L38 S77 A78 G79 K80 P81 I98 V118 A119 N120 V144 T218 P222 G9 K10 I11 Y31 D32 I33 I34 L37 S76 A77 G78 K79 P80 I97 V117 A118 N119 V143 T217 P221 1.1.1.37 30638660 AKVGFIGAGKIGQTIAYSALVSGAVDEAVIYDIIPELPDKFEHELRHAFATKGIKANVLGTNSLDDVSGMDIVVISAGKPRKPGMSRRDLFVDNAKIMIDLAQKLPSKNPGAIYLMVANPVDMMASVFMKYSKQFTISAGDQVETMRMRSFIAKKLKIPVTSVDGFVGGEHGEDAVVLWSTVKIKGKPVDEFNINKDEVSDYVKKIPGEIIRVIGGTTWGPGTIIADIIKSIAFSENRVMSIATPKEYEKEIIHVSAPTVVGSSIGPSLESLLDEKDRWHLNSAMKDFYEAYKENLKQLEQAT 6ihe B 1.90 BS02 MLT B 1 R82 R88 N120 R148 I212 T218 R81 R87 N119 R147 I211 T217 1.1.1.37 30638660 AKVGFIGAGKIGQTIAYSALVSGAVDEAVIYDIIPELPDKFEHELRHAFATKGIKANVLGTNSLDDVSGMDIVVISAGKPRKPGMSRRDLFVDNAKIMIDLAQKLPSKNPGAIYLMVANPVDMMASVFMKYSKQFTISAGDQVETMRMRSFIAKKLKIPVTSVDGFVGGEHGEDAVVLWSTVKIKGKPVDEFNINKDEVSDYVKKIPGEIIRVIGGTTWGPGTIIADIIKSIAFSENRVMSIATPKEYEKEIIHVSAPTVVGSSIGPSLESLLDEKDRWHLNSAMKDFYEAYKENLKQLEQAT 6ijm A 2.02 BS01 ZN A 1 H13 H15 H217 D295 H14 H16 H200 D278 HMEWIQSLPKIELHAHLNGSIRDSTLLELARVLGEKGVIVFADVEHVIQRSLVEVFKLFDLIHKLTTDHKTVTRITREVVEDFALENVVYLELRTTPKRSDSIGMSKRSYMEAVIQGLRSVSEVDIDFVTRKKIYVRLLLSIDRRETTESAMETVKLALEMRDVGVVGIDLSGNPLVGEWSTFLPALQYAKDNDLHITLHCGEVPNPKEIQAMLDFKPHRIGHACFFKDEDWTKLKSFRIPVEICLTSNIVTKSISSIDIHHFADLYNAKHPLILCTDDFGVFSTSLSNEYALAVRSLGLSKSETFALARAAIDATFAEDEVKQQLRFIFDSASPEH 6ijn A 1.66 BS01 6MZ A 1 H15 L16 N17 F58 F61 H65 T97 T98 K100 D160 G190 H217 E220 N295 D296 H16 L17 N18 F59 F62 H66 T98 T99 K101 D146 G176 H203 E206 N281 D282 HMEWIQSLPKIELHAHLNGSIRDSTLLELARVLGEKGVIVFADVEHVIQKNDRSLVEVFKLFDLIHKLTTDHKTVTRITREVVEDFALENVVYLELRTTPKRSDSIGMSKRSYMEAVIQGLRSVSEVDIDFVTRKKIYVRLLLSIDRRETTESAMETVKLALEMRDVGVVGIDLSGNPLVGEWSTFLPALQYAKDNDLHITLHCGEVPNPKEIQAMLDFKPHRIGHACFFKDEDWTKLKSFRIPVEICLTSNIVTKSISSIDIHHFADLYNAKHPLILCTNDFGVFSTSLSNEYALAVRSLGLSKSETFALARAAIDATFAEDEVKQQLRFIFDSASPEHV 6ijp A 1.85 BS02 IMP A 1 H15 L16 N17 F58 F61 H65 T97 T98 K100 D160 S189 G190 H217 E220 D296 H16 L17 N18 F59 F62 H66 T98 T99 K101 D146 S175 G176 H203 E206 D282 HMEWIQSLPKIELHAHLNGSIRDSTLLELARVLGEKGVIVFADVEHVIQKNDRSLVEVFKLFDLIHKLTTDHKTVTRITREVVEDFALENVVYLELRTTPKRSDSIGMSKRSYMEAVIQGLRSVSEVDIDFVTRKKIYVRLLLSIDRRETTESAMETVKLALEMRDVGVVGIDLSGNPLVGEWSTFLPALQYAKDNDLHITLHCGEVPNPKEIQAMLDFKPHRIGHACFFKDEDWTKLKSFRIPVEICLTSNIVTKSISSIDIHHFADLYNAKHPLILCTDDFGVFSTSLSNEYALAVRSLGLSKSETFALARAAIDATFAEDEVKQQLRFIFDSASPEH 6iu3 A 2.70 BS01 ZN A 1 E102 E105 E113 E116 E153 E71 E74 E82 E85 E122 EIVRDIIIGVSDGLTVPFALAAGLSGANASSSIVLTAGIAEVAAGAISMGLGGYLAAKSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEKPDPKRALQSAFTIAIAYVLGGLVPLIPYMFIPVARKAVVASVILTLMALLIFGYAKGYFTDNKPFKSALQTALIGAIASAAAFGMAKAVQSENLYFQ 6iu3 A 2.70 BS02 ZN A 2 E102 E113 E116 M149 E71 E82 E85 M118 EIVRDIIIGVSDGLTVPFALAAGLSGANASSSIVLTAGIAEVAAGAISMGLGGYLAAKSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEKPDPKRALQSAFTIAIAYVLGGLVPLIPYMFIPVARKAVVASVILTLMALLIFGYAKGYFTDNKPFKSALQTALIGAIASAAAFGMAKAVQSENLYFQ 6iu3 A 2.70 BS03 ZN A 3 E102 E105 E113 E116 E71 E74 E82 E85 EIVRDIIIGVSDGLTVPFALAAGLSGANASSSIVLTAGIAEVAAGAISMGLGGYLAAKSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEKPDPKRALQSAFTIAIAYVLGGLVPLIPYMFIPVARKAVVASVILTLMALLIFGYAKGYFTDNKPFKSALQTALIGAIASAAAFGMAKAVQSENLYFQ 6iu4 A 3.50 BS01 ZN A 1 E102 E105 E72 E75 GEIVRDIIIGVSDGLTVPFALAAGLSGANASSSIVLTAGIAEVAAGAISMGLGGYLAAKSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEKPDPKRALQSAFTIAIAYVLGGLVPLIPYMFIPVARKAVVASVILTLMALLIFGYAKGYFTDNKPFKSALQTALIGAIASAAAFGMAKAVQSENLYFQ 6iu4 A 3.50 BS04 CO A 1 D43 M80 D13 M50 GEIVRDIIIGVSDGLTVPFALAAGLSGANASSSIVLTAGIAEVAAGAISMGLGGYLAAKSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEKPDPKRALQSAFTIAIAYVLGGLVPLIPYMFIPVARKAVVASVILTLMALLIFGYAKGYFTDNKPFKSALQTALIGAIASAAAFGMAKAVQSENLYFQ 6iu5 A 2.25 BS02 ZN A 2 E102 E113 E116 M149 E153 E16 E27 E30 M63 E67 GSHSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEK 6iu5 A 2.25 BS03 ZN A 3 E105 E113 E116 E19 E27 E30 GSHSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEK 6iu5 B 2.25 BS04 ZN B 4 H89 E91 H3 E5 GSHSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEKPD 6iu5 I 2.25 BS02 ZN I 2 E127 H129 E41 H43 GSHSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEKP 6iu6 A 2.90 BS04 NI A 3 E127 H129 E130 E41 H43 E44 GSHSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEK 6iu6 B 2.90 BS05 ZN B 4 G87 H89 G1 H3 GSHSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEKPD 6iu8 D 2.70 BS02 CO D 1 E102 E105 E113 E116 M149 E153 E16 E19 E27 E30 M63 E67 GSHSEADNYARELKREQEEIIRVPDTEAAEVAEILARYGIEPHEYGPVVNALRKKPQAWLDFMMKFELGLEK 6iv7 A 1.94 BS01 SAH A 1 L193 G227 G229 D252 L253 V256 H274 N275 F276 H277 R291 L192 G226 G228 D251 L252 V255 H273 N274 F275 H276 R290 2.1.1.- ETVAAIKTLIQQLAQSTDQFGRAEINDALRELQYSLETPFDTVMRMSLDTCQVAVARIGSDLGLFKHLSQCASPQSAEELADHLGCGRELMSRLLRYMASVRMVQQTDDIKYISSNITQTLAVPGLEAGMRHAFENLWPVLMALPDFLAERKYPDIVDAKDTAFQKAFNTDQDCFHWLATQPTRIANFKVLLTDERTPNFLSTFPLEKELGSWSAEPEKALFVDIGGGMGHACIRLREKYPNQPGRVILQDLPPVLQAAQATLPLSGIESMPHNFHTPQPVQGAKFYFLRLILRDFPDHQALEILQNIVPAMDAESRIVIDDGVPPEKGARWAETGTDICIMSALGSKERTQRQWEELAAKAGLQLQALYQYTWPVVNAAMVFSLQ 6iwq A 2.95 BS01 MN A 1 D301 H303 H440 D190 H192 H329 2.4.1.- 30685086 YLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPLIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPQEKRLRKTKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPIYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSHYPLPPKNVDWGEIRGFETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFTHIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV 6iwr C 2.60 BS01 MN C 1 D301 H303 H440 R443 D190 H192 H329 R332 2.4.1.- 30685086 YLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPLIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPQEKRLRKTKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPIYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSHYPLPPKNVDWGEIRGFETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFTHIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV 6iwr D 2.60 BS01 UDP D 1 V214 F215 H216 E218 D247 R277 L280 D301 A302 H303 R443 V103 F104 H105 E107 D136 R166 L169 D190 A191 H192 R332 2.4.1.- 30685086 YLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPLIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPQEKRLRKTKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGSSPTLKNYVRVVEVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSHYPLPPKNVDWGEIRGFETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFTHIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV 6iwr D 2.60 BS03 UD2 D 1 S459 D547 M549 H563 M565 G566 G567 N568 Q569 S340 D428 M430 H444 M446 G447 G448 N449 Q450 2.4.1.- 30685086 YLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPLIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPQEKRLRKTKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGSSPTLKNYVRVVEVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSHYPLPPKNVDWGEIRGFETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFTHIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV 6j63 A 2.62 BS02 NTD A 1 H226 V228 N282 H308 L368 Q379 F381 F392 E394 F419 G420 N423 F424 H179 V181 N226 H248 L308 Q319 F321 F332 E334 F352 G353 N356 F357 1.13.11.27 30632699 SKFVRKNPKSDKFKVKRFHHIEFWCGDATNVARRFSWGLGMRFSAKSDLSTGNMVHASYLLTSGDLRFLFTAPYSPSLTTTASIPSFDHGSCRSFFSSHGLGVRAVAIEVEDAESAFSISVANGAIPSSPPIVLNEAVTIAEVKLYGDVVLRYVSYKEFLPGFERVEDPLDYGIRRLDHAVGNVPELGPALTYVAGFTGFHQFAEFSGLNSAVLASNDEMVLLPINEPVRKSQIQTYLEHNEGAGLQHLALMSEDIFRTLREMRKRSSIGGFDFMPSPPPTYYQNLKKRVGDVLSDDQIKECEELGILVDRDDQGTLLQIFTKPLGDRPTIFIEIIQRVGCMMYQSGGCGGFGKGNFSELFKSIEEY 6j63 D 2.62 BS02 NTD D 1 N282 H308 L368 Q379 F381 F392 E394 F419 G420 N423 F424 N227 H251 L311 Q322 F324 F335 E337 F355 G356 N359 F360 1.13.11.27 30632699 SKFVRKNPKSDKFKVKRFHHIEFWCGDATNVARRFSWGLGMRFSAKSDLSTGNMVHASYLLTSGDLRFLFTAPYSPSLTTTASIPSFDHGSCRSFFSSHGLGVRAVAIEVEDAESAFSISVANGAIPSSPPIVLNEAVTIAEVKLYGDVVLRYVSYKEFLPGFERVEDFPLDYGIRRLDHAVGNVPELGPALTYVAGFTGFHQFAEFSGLNSAVLASNDEMVLLPINEPVHGRKSQIQTYLEHNEGAGLQHLALMSEDIFRTLREMRKRSSIGGFDFMPSPPPTYYQNLKKRVGDVLSDDQIKECEELGILVDRDDQGTLLQIFTKPLGDRPTIFIEIIQRVGCMMYQSGGCGGFGKGNFSELFKSIEEY 6j9t F 2.70 BS01 FBP F 1 R159 R171 S172 H174 R157 R169 S170 H172 1.1.1.27 SITDKDHQKVILVGDGAVGSSYAYAMVLQGIAQEIGIVDIFKDKTKGDAIDLSNALPFTSPKKIYSAEYSDAKDADLVVITAGAPQKPGETRLDLVNKNLKILKSIVDPIVDSGFNGIFLVAANPVDILTYATWKLSGFPKNRVVGSGTSLDTARFRQSIAEMVNVDARSVHAYIMGEHGDTEFPVWSHANIGGVTIAEWVKAHPEIKEDKLVKMFEDVRDAAYEIIKLKGATFYGIATALARISKAILNDENAVLPLSVYMDGQYGLNDIYIGTPAVINRNGIQNILEIPLTDHEEESMQKSASQLKKVLTDAFA 6j9u A 2.79 BS01 PYR A 1 R94 N126 L153 R157 H181 T235 R86 N118 L145 R149 H173 T227 1.1.1.27 ITDKDHQKVILVGDGAVGSSYAYAMVLQGIAQEIGIVDIFKDKTKGDAIDLEDALPFTSPKKIYSAEYSDAKDADLVVITAGAPTRLDLVNKNLKILKSIVDPIVDSGFNGIFLVAANPVDILTYATWKLSGFPKNRVVGSGTSLDTARFRQSIAKMVNVDARSVHAYIMGEHGDTEFPVWSHANIGGVTIAEWVKAHPEIKEDKLVKMFEDVRNKAYEIIKLKGATFYGIATALARISKAILNDENAVLPLSVYMDGQYGLNDIYIGTPAVINRNGIQNILEIPLTDHEEESMQKSASQLKKVLT 6m9r A 1.69 BS01 J9Y A 1 R48 L396 E398 S404 H407 H409 M422 H448 A450 Y459 R45 L381 E383 S389 H392 H394 M407 H433 A435 Y444 1.-.-.- VPPHVPFELSGAELRDAIVQYATNPIYHDNLDWLNHDNPYRRQLRPQVLPHLDYDKVPGRENILNYASLAVQRLLTSVYEADLVFFPKSGLKGKEEDFRAFYSPANRALGERIRPALERYAFGFLDDEVETWTAQSLDAYLDSLEQSPVEKAILGSADRERAARMWLVQFAPDFLSEASPMMRNVLGYYGPAQSEWFKVVIDEGVHDTKHSTLFERTLESVGLESDLHRYWQYYLNSSLLLNNYFHYLGKNHELFFRYVGALYYTESSLVDFCRRADHLLREVFGDTVDTTYFTEHIHIDQHHGRMAREKIIKPLVEAHGDGIIPEIVRGIEEYRVLLEIGDFDFSEQIAWMDAQPELKKLHDPVFEGLKQGKVDAPVAHLVEPRGELSNTHCHDGDELCHIVSGTMRFESGLGSSLTLQAGEGVVIKRNRLHGANIESDECVYEIHSVGDYRKCL 6m9r A 1.69 BS02 FE A 1 H407 H409 H448 H392 H394 H433 1.-.-.- VPPHVPFELSGAELRDAIVQYATNPIYHDNLDWLNHDNPYRRQLRPQVLPHLDYDKVPGRENILNYASLAVQRLLTSVYEADLVFFPKSGLKGKEEDFRAFYSPANRALGERIRPALERYAFGFLDDEVETWTAQSLDAYLDSLEQSPVEKAILGSADRERAARMWLVQFAPDFLSEASPMMRNVLGYYGPAQSEWFKVVIDEGVHDTKHSTLFERTLESVGLESDLHRYWQYYLNSSLLLNNYFHYLGKNHELFFRYVGALYYTESSLVDFCRRADHLLREVFGDTVDTTYFTEHIHIDQHHGRMAREKIIKPLVEAHGDGIIPEIVRGIEEYRVLLEIGDFDFSEQIAWMDAQPELKKLHDPVFEGLKQGKVDAPVAHLVEPRGELSNTHCHDGDELCHIVSGTMRFESGLGSSLTLQAGEGVVIKRNRLHGANIESDECVYEIHSVGDYRKCL 6m9r B 1.69 BS01 J9Y B 1 R48 E398 S404 H407 H409 M422 H448 A450 Y459 R46 E381 S387 H390 H392 M405 H431 A433 Y442 1.-.-.- HVPPHVPFELSGAELRDAIVQYATNPIYHDNLDWLNHDNPYRRQLRPQVLPHLDYDKVPGRENILNYASLAVQRLLTSVYEADLVFFPKSGLKGKEEDFRAFYSPANRALGERIRPALERYAFGFLDDEVETWTAQSLDAYLDSLDEQSPVEKAILGSADRERAARMWLVQFAPDFLSEASPMMRNVLGYYGPAQSEWFKVVIDETKHSTLFERTLESVGLESDLHRYWQYYLNSSLLLNNYFHYLGKNHELFFRYVGALYYTESSLVDFCRRADHLLREVFGDTVDTTYFTEHIHIDQHHGRMAREKIIKPLVEAHGDGIIPEIVRGIEEYRVLLEIGDFDFSEQIAWMDAQPELKKLHDPVFEGLKQGKVDAPVAHLVEPRGELSNTHCHDGDELCHIVSGTMRFESGLGSSLTLQAGEGVVIKRNRLHGANIESDECVYEIHSVGDYRKCL 6m9s A 2.08 BS02 FE A 2 E189 E215 H225 H311 E181 E205 H215 H301 1.-.-.- HVPPHVPFELSGAELRDAIVQYATNPIYHDNLDWLNHDNPYRRQLRPQVLPHLDYDKVPGRENILNYASLAVQRLLTSVYEADLVFFPKSGLKGKEEDFRAFYSPANRALGERIRPALERYAFGFLDDEVETSGTWTAQSLDAYLDSLDEQSPVEKAILGSADRERAARWLVQFAPDFLSEASPRNVLGYYGPAQSEWFKVVIDEYGYGVHDTKHSTLFERTLESVGLESDLHRYWQYYLNSSLLLNNYFHYLGKNHELFFRYVGALYYTESSLVDFCRRADHLLREVFGDTVDTTYFTEHIAREKIIKPLVEAHGDGIIPEIVRGIEEYRVLLEIGDFDFSEQIAWDAQPELKKLHDPVFEGLKQGKVDAPVAHLVEPRGELSNTHCHDGDELCHIVSGTRFESGLGSSLTLQAGEGVVIKRNRLHGANIESDECVYEIHSVGDYRKCL 6mat A 4.50 BS01 III G 1 T276 K574 Y575 T84 K382 Y383 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPSVKDPEKYMHS 6mat A 4.50 BS02 ATP A 1 H502 P544 G545 C546 G547 K548 T549 L550 N645 H310 P352 G353 C354 G355 K356 T357 L358 N453 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPSVKDPEKYMHS 6mat A 4.50 BS03 ATP A 2 D203 S245 G246 C247 G248 K249 T250 T251 D11 S53 G54 C55 G56 K57 T58 T59 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPSVKDPEKYMHS 6mat B 4.50 BS01 III G 1 S277 K574 Y575 S85 K382 Y383 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPSVKDPEKYMHS 6mat B 4.50 BS02 ATP A 1 D630 R656 R659 D438 R464 R467 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPSVKDPEKYMHS 6mat B 4.50 BS03 ATP A 3 D331 R362 D139 R170 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPSVKDPEKYMHS 6mat B 4.50 BS05 ATP B 2 D203 S245 G246 C247 G248 K249 T250 T251 Q412 D11 S53 G54 C55 G56 K57 T58 T59 Q220 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPSVKDPEKYMHS 6mat D 4.50 BS01 III G 1 G275 S277 K574 Y575 V576 G83 S85 K382 Y383 V384 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPSVKDPEKYMHS 6mat E 4.50 BS01 III G 1 S277 K316 K574 Y575 V576 S85 K124 K382 Y383 V384 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPS 6mat E 4.50 BS02 ATP D 1 R656 R659 R464 R467 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPS 6mat E 4.50 BS04 ATP E 1 D203 S245 G246 C247 G248 K249 T250 T251 G408 S409 Q412 D11 S53 G54 C55 G56 K57 T58 T59 G216 S217 Q220 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPS 6mat F 4.50 BS01 ATP F 1 G547 T549 L550 T680 G355 T357 L358 T488 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPS 6mat F 4.50 BS02 ATP F 2 D203 S245 G246 C247 G248 K249 T250 T251 I380 D11 S53 G54 C55 G56 K57 T58 T59 I188 RTPPTKVSILDIAGVDDTLQRLLKEVWFPLRGGEACEKMGYRYDNGVLLHGPSGCGKTTLAHAIAGSIGVAFIPVSAPSVIGGTSGESEKNIRDVFDEAIRLAPCLIFLDQIDAIAGRRESANKGMESRIVAEIMNGMDRIRQNTPLGKNVVVLAATNRPEFLDPAIRRRFSVEIDMGMPSERAREQILRSLTRDLSLADDINFKELAKMTPGYVGSDLQYVVKAAVSESFQANIDSLLAQARAKHPADHLANVSQPQRDWLLLEAHRDEEVSWPSTKITMEQFRKAVSLVQPASKREGFSTIPDTTWSHVGALEDVRKKLEMSIIGPIKNPELFTRVGIKPAAGILLWGPPGCGKTLVAKAVANESKANFISIKGPELLNKYVGESERAVRQLFSRAKSSAPCILFFDQMDALVPRRDDSLSDASARVVNTLLTELDGVGDRSGIYVIGATNRPDMIDEAIRRPGRLGTSIYVGLPSAEDRVKILKTLYRNTVQGTTDADLEKVALDLRCTGFSGADLGNLMQAAAQACLERVYTQRQQKRKEGEEEIEPVITMEDWEKALNEVKPS 6mds A 2.50 BS01 GAL A 1 H107 F172 R176 H62 F127 R131 TDQQVGAKLVQEIREGKRGPLYAGYFRTWHDRASTGIDGKQQHPENTMAEVPKEVDILFVFHDHTASDSPFWSELKDSYVHKLHQQGTALVQTIGVNELNGRTGLSKDYPDTPEGNKALAAAIVKAFVTDRGVDGLDIDIEHEFTNKRTPEEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENNPIFKGIAEDLDYLLRQYYGSQGGEAEVDTINSDWNQYQNYIDASQFMIGFSFFEESASKGNLWFDVNEYDPNNPEKGKDIEGTRAKKYAEWQPSTGGLKAGIFSYAIDRDGVAHVPSTYKNRTSTNLQRHEVDNISHTDYTVSRKLKTLMTEDKRYDVIDQKDIPDPALREQIIQQVGQYKGDLERYNKTLVLTGDKIQNLKGLEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKSEDRKLLMTLMEQVSNHQKITVKNTAFENQKPKGYYPQTYDTKEGHYDVDNAEHDILTDFVFGTVTKRNTFIGDEEAFAIYKEGAVDGRQYVSKDYTYEAFRKDYKGYKVHLTASNLGETVTSKVTATTDETYLVDVSDGEKVVHHMKLNIGSGAIMMENLAKGAKVIGTSGDFEQAKKIFDGEKSDRFFTWGQTNWIAFDLGEINLAKEWRLFNAETNTEIKTDSSLNVAKGRLQILKDTTIDLEKMDIKNRKEYLSNDENWTDVAQMDDAKAIFNSKLSNVLSRYWRFCVDGGASSYYPQYTELQILGQR 6mdv A 2.50 BS02 BMA A 1 F106 D108 E288 Y339 F61 D63 E243 Y294 TDQQVGAKLVQEIREGKRGPLYAGYFRTWHDRASTGIDGKQQHPENTMAEVPKEVDILFVFHDHTASDSPFWSELKDSYVHKLHQQGTALVQTIGVNELNGRTGLSKDYPDTPEGNKALAAAIVKAFVTDRGVDGLDIDIEHEFTNKRTPEEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENNPIFKGIAEDLDYLLRQYYGSQGGEAEVDTINSDWNQYQNYIDASQFMIGFSFFEESASKGNLWFDVNEYDPNNPEKGKDIEGTRAKKYAEWQPSTGGLKAGIFSYAIDRDGVAHVPSTYKNRTSTNLQRHEVDNISHTDYTVSRKLKTLMTEDKRYDVIDQKDIPDPALREQIIQQVGQYKGDLERYNKTLVLTGDKIQNLKGLEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKSEDRKLLMTLMEQVSNHQKITVKNTAFENQKPKGYYPQTYDTKEGHYDVDNAEHDILTDFVFGTVTKRNTFIGDEEAFAIYKEGAVDGRQYVSKDYTYEAFRKDYKGYKVHLTASNLGETVTSKVTATTDETYLVDVSDGEKVVHHMKLNIGSGAIMMENLAKGAKVIGTSGDFEQAKKIFDGEKSDRFFTWGQTNWIAFDLGEINLAKEWRLFNAETNTEIKTDSSLNVAKGRLQILKDTTIDLEKMDIKNRKEYLSNDENWTDVAQMDDAKAIFNSKLSNVLSRYWRFCVDGGASSYYPQYTELQILGQR 6mdv A 2.50 BS03 MAN A 1 R72 W74 E288 E289 A291 N295 R27 W29 E243 E244 A246 N250 TDQQVGAKLVQEIREGKRGPLYAGYFRTWHDRASTGIDGKQQHPENTMAEVPKEVDILFVFHDHTASDSPFWSELKDSYVHKLHQQGTALVQTIGVNELNGRTGLSKDYPDTPEGNKALAAAIVKAFVTDRGVDGLDIDIEHEFTNKRTPEEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENNPIFKGIAEDLDYLLRQYYGSQGGEAEVDTINSDWNQYQNYIDASQFMIGFSFFEESASKGNLWFDVNEYDPNNPEKGKDIEGTRAKKYAEWQPSTGGLKAGIFSYAIDRDGVAHVPSTYKNRTSTNLQRHEVDNISHTDYTVSRKLKTLMTEDKRYDVIDQKDIPDPALREQIIQQVGQYKGDLERYNKTLVLTGDKIQNLKGLEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKSEDRKLLMTLMEQVSNHQKITVKNTAFENQKPKGYYPQTYDTKEGHYDVDNAEHDILTDFVFGTVTKRNTFIGDEEAFAIYKEGAVDGRQYVSKDYTYEAFRKDYKGYKVHLTASNLGETVTSKVTATTDETYLVDVSDGEKVVHHMKLNIGSGAIMMENLAKGAKVIGTSGDFEQAKKIFDGEKSDRFFTWGQTNWIAFDLGEINLAKEWRLFNAETNTEIKTDSSLNVAKGRLQILKDTTIDLEKMDIKNRKEYLSNDENWTDVAQMDDAKAIFNSKLSNVLSRYWRFCVDGGASSYYPQYTELQILGQR 6mdv A 2.50 BS04 MAN A 2 W74 Q87 H88 H109 W29 Q42 H43 H64 TDQQVGAKLVQEIREGKRGPLYAGYFRTWHDRASTGIDGKQQHPENTMAEVPKEVDILFVFHDHTASDSPFWSELKDSYVHKLHQQGTALVQTIGVNELNGRTGLSKDYPDTPEGNKALAAAIVKAFVTDRGVDGLDIDIEHEFTNKRTPEEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENNPIFKGIAEDLDYLLRQYYGSQGGEAEVDTINSDWNQYQNYIDASQFMIGFSFFEESASKGNLWFDVNEYDPNNPEKGKDIEGTRAKKYAEWQPSTGGLKAGIFSYAIDRDGVAHVPSTYKNRTSTNLQRHEVDNISHTDYTVSRKLKTLMTEDKRYDVIDQKDIPDPALREQIIQQVGQYKGDLERYNKTLVLTGDKIQNLKGLEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKSEDRKLLMTLMEQVSNHQKITVKNTAFENQKPKGYYPQTYDTKEGHYDVDNAEHDILTDFVFGTVTKRNTFIGDEEAFAIYKEGAVDGRQYVSKDYTYEAFRKDYKGYKVHLTASNLGETVTSKVTATTDETYLVDVSDGEKVVHHMKLNIGSGAIMMENLAKGAKVIGTSGDFEQAKKIFDGEKSDRFFTWGQTNWIAFDLGEINLAKEWRLFNAETNTEIKTDSSLNVAKGRLQILKDTTIDLEKMDIKNRKEYLSNDENWTDVAQMDDAKAIFNSKLSNVLSRYWRFCVDGGASSYYPQYTELQILGQR 6mdv A 2.50 BS05 MAN A 3 N142 E186 E188 N97 E141 E143 TDQQVGAKLVQEIREGKRGPLYAGYFRTWHDRASTGIDGKQQHPENTMAEVPKEVDILFVFHDHTASDSPFWSELKDSYVHKLHQQGTALVQTIGVNELNGRTGLSKDYPDTPEGNKALAAAIVKAFVTDRGVDGLDIDIEHEFTNKRTPEEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENNPIFKGIAEDLDYLLRQYYGSQGGEAEVDTINSDWNQYQNYIDASQFMIGFSFFEESASKGNLWFDVNEYDPNNPEKGKDIEGTRAKKYAEWQPSTGGLKAGIFSYAIDRDGVAHVPSTYKNRTSTNLQRHEVDNISHTDYTVSRKLKTLMTEDKRYDVIDQKDIPDPALREQIIQQVGQYKGDLERYNKTLVLTGDKIQNLKGLEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKSEDRKLLMTLMEQVSNHQKITVKNTAFENQKPKGYYPQTYDTKEGHYDVDNAEHDILTDFVFGTVTKRNTFIGDEEAFAIYKEGAVDGRQYVSKDYTYEAFRKDYKGYKVHLTASNLGETVTSKVTATTDETYLVDVSDGEKVVHHMKLNIGSGAIMMENLAKGAKVIGTSGDFEQAKKIFDGEKSDRFFTWGQTNWIAFDLGEINLAKEWRLFNAETNTEIKTDSSLNVAKGRLQILKDTTIDLEKMDIKNRKEYLSNDENWTDVAQMDDAKAIFNSKLSNVLSRYWRFCVDGGASSYYPQYTELQILGQR 6mdv B 2.50 BS02 BMA B 1 F106 D108 H109 E288 Y339 F61 D63 H64 E243 Y294 TDQQVGAKLVQEIREGKRGPLYAGYFRTWHDRASTGIDGKQQHPENTMAEVPKEVDILFVFHDHTASDSPFWSELKDSYVHKLHQQGTALVQTIGVNELNGRTGLSKDYPDTPEGNKALAAAIVKAFVTDRGVDGLDIDIEHEFTNKRTPEEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENNPIFKGIAEDLDYLLRQYYGSQGGEAEVDTINSDWNQYQNYIDASQFMIGFSFFEESASKGNLWFDVNEYDPNNPEKGKDIEGTRAKKYAEWQPSTGGLKAGIFSYAIDRDGVAHVPSTYKNRTSTNLQRHEVDNISHTDYTVSRKLKTLMTEDKRYDVIDQKDIPDPALREQIIQQVGQYKGDLERYNKTLVLTGDKIQNLKGLEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKSEDRKLLMTLMEQVSNHQKITVKNTAFENQKPKGYYPQTYDTKEGHYDVDNAEHDILTDFVFGTVTKRNTFIGDEEAFAIYKEGAVDGRQYVSKDYTYEAFRKDYKGYKVHLTASNLGETVTSKVTATTDETYLVDVSDGEKVVHHMKLNIGSGAIMMENLAKGAKVIGTSGDFEQAKKIFDGEKSDRFFTWGQTNWIAFDLGEINLAKEWRLFNAETNTEIKTDSSLNVAKGRLQILKDTTIDLEKMDIKNRKEYLSNDENWTDVAQMDDAKAIFNSKLSNVLSRYWRFCVDGGASSYYPQYTELQILGQR 6mpz A 2.00 BS01 III M 1 A24 L25 C27 G58 S59 N60 A61 L62 L65 G77 Y78 R79 H96 N100 H101 F102 I137 A20 L21 C23 G54 S55 N56 A57 L58 L61 G73 Y74 R75 H92 N96 H97 F98 I133 30638446 QIQPVTRGRAKVPVIMQMEALECGAASLAMVLAYYKKWVPLEQVRVDCGVSRDGSNALNVLKAARNYGLEAKGYRYEPEKLKKEGTFPCIIHWNFNHFVVLKGFKGKYAYINDPAKGDVKIPMEEFDRSFTGICLIFKPTDR 6mpz B 2.00 BS01 III N 1 A24 C27 G58 S59 N60 A61 L62 L65 K76 G77 Y78 R79 H96 N100 H101 F102 I137 A20 C23 G54 S55 N56 A57 L58 L61 K72 G73 Y74 R75 H92 N96 H97 F98 I133 30638446 QIQPVTRGRAKVPVIMQMEALECGAASLAMVLAYYKKWVPLEQVRVDCGVSRDGSNALNVLKAARNYGLEAKGYRYEPEKLKKEGTFPCIIHWNFNHFVVLKGFKGKYAYINDPAKGDVKIPMEEFDRSFTGICLIFKPT 6ms1 A 1.35 BS01 III D 1 G737 L738 G739 I740 S741 I742 A743 S748 T749 Y751 S761 H793 V797 L800 R801 G16 L17 G18 I19 S20 I21 A22 S27 T28 Y30 S40 H72 V76 L79 R80 30659601 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRER 6ms1 B 1.35 BS01 III C 1 G737 L738 G739 I740 S741 I742 A743 G744 G747 S748 T749 Y751 S761 R762 H793 V797 L800 G16 L17 G18 I19 S20 I21 A22 G23 G26 S27 T28 Y30 S40 R41 H72 V76 L79 30659601 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRER 6n3t A 2.79 BS01 L9Q A 1 F43 D64 T66 V70 S136 G170 L171 L174 S428 Q442 F445 F452 R453 T454 R501 P502 N504 F43 D64 T66 V70 S136 G170 L171 L174 S399 Q413 F416 F423 R424 T425 R472 P473 N475 MFAWWGRTVYQFRYIVIGVMVALCLGGGVYGISLGNHVTQSGFYDEGSQSVAASLIGDEVYGRDRTSHVVAILTPPDDKKVTDKAWQKKVTEELDQVVKDHEDQIVGWVGWLKAPDTTDPTVSAMKTQDLRHTFISIPLQGDDDDEILKNYQVVEPELQQVNGGDIRLAGLNPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGTVIAAALPAIIGGLAIAGALGIMRLVAEFTPVHFFAQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTVMTSGRTVVFSAVIIVASSVPLLLFPQGFLKSITYAIIASVMLAAILSITVLAAALAILGPRVDALGVTTREEVERGFWGRLVNVVMKRPIAFAAPILVVMVLLIIPLGQLSLGGISEKYLPPDNAVRQSQEQFDKLFPGFRTEPLTLVMKREDGEPITDAQIADMRAKALTVSGFTDPDNDPEKMWKERPANDSGSKDPSVRVIQNGLENRNDAAKKIDELRALQPPHGIEVFVGGTPALEQDSIHSLFDKLPLMALILIVTTTVLMFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLMAPMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALILAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAVMKLLGDDCWWAPRWMKRVQEKLGLGETELP 6n4u A 2.75 BS01 CA A 1 D39 H69 C73 M225 D39 H69 C73 M225 3.4.21.64 30661853 AAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFEGRAQMVKTYYYSSRDGNGHGTHCAGTVGSRTYGVAKKTQLFGVKVLDDNGSGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGGGYSSSVNSAAARLQSSGVMVAVAAGNNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLDIFGPGTDILSTWIGGSTRSISGTSMATPHVAGLAAYLMTLGKTTAASACRYIADTANKGDLSNIPFGTVNLLAYNNYQA 6n4u A 2.75 BS02 CA A 2 V269 N270 V269 N270 3.4.21.64 30661853 AAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFEGRAQMVKTYYYSSRDGNGHGTHCAGTVGSRTYGVAKKTQLFGVKVLDDNGSGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGGGYSSSVNSAAARLQSSGVMVAVAAGNNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLDIFGPGTDILSTWIGGSTRSISGTSMATPHVAGLAAYLMTLGKTTAASACRYIADTANKGDLSNIPFGTVNLLAYNNYQA 6n9m A 1.45 BS01 DCF A 1 H14 D16 L56 L60 I139 S141 A169 G170 H197 E200 H221 D278 D279 H14 D16 L56 L60 I139 S141 A169 G170 H197 E200 H221 D278 D279 3.5.4.4 MIDITLPLTDIHRHLDGNIRAQTILDLGRQFNIALPAQTLETLIPHVQVTSTEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPIAGVVEAVIDGVRDGCNTFGVEARLIGIMSRTFGEAACLQELDALLAHRENITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLAQQRIGIESCLTSNIQTSTVASLADHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYHVAAPAAGLSREQIRQAQINGLEIAFLSDSEKRALREKVA 6n9m A 1.45 BS02 ZN A 1 H12 H14 H197 D278 H12 H14 H197 D278 3.5.4.4 MIDITLPLTDIHRHLDGNIRAQTILDLGRQFNIALPAQTLETLIPHVQVTSTEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPIAGVVEAVIDGVRDGCNTFGVEARLIGIMSRTFGEAACLQELDALLAHRENITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLAQQRIGIESCLTSNIQTSTVASLADHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYHVAAPAAGLSREQIRQAQINGLEIAFLSDSEKRALREKVA 6n9m A 1.45 BS03 CA A 1 G131 E133 G131 E133 3.5.4.4 MIDITLPLTDIHRHLDGNIRAQTILDLGRQFNIALPAQTLETLIPHVQVTSTEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPIAGVVEAVIDGVRDGCNTFGVEARLIGIMSRTFGEAACLQELDALLAHRENITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLAQQRIGIESCLTSNIQTSTVASLADHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYHVAAPAAGLSREQIRQAQINGLEIAFLSDSEKRALREKVA 6n9p A 2.23 BS01 KHD A 1 L408 V416 A428 K430 M449 T474 E475 M477 C481 R525 L528 S538 D539 F540 L20 V28 A40 K42 M61 T86 E87 M89 C93 R137 L140 S150 D151 F152 2.7.10.2 30521698 GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES 6nch B 2.00 BS01 RB5 B 1 Y27 R31 W98 Y26 R30 W97 TIKWIDWVKQIQSIAQAGLTYSKDVYDIERFQQLRDISISMMSHYTKTDWEVVEKLFASETGYQTPKVDIRAVVFQNEKLLFVKEKSDGKWALPGGWADVGYTPTEVAAKEVFEETGYEVDHFKLLAIFDKETHVYKIFIGCEIIGGEKKTSIETEEVEFFGENELPNLSIARNTEDQIKEMFAYMKDPQKEKLID 6npo A 2.40 BS01 III C 1 T69 D70 T71 Y147 F307 Y407 F439 L443 G457 W458 S459 D461 T26 D27 T28 Y104 F264 Y364 F396 L400 G414 W415 S416 D418 EKLAAKQVFNKTENQEIPTMDTSKSTDTLGSQILGNTMEGLYRLDKENKPIPAAAESSTKSEDGKKYTFKLRKDAKWSNGDSVTAKDFVFAWQRLLDPKTAAEYAFIAFPIKNAEAVNKGEKPVTELGVKAVDDLTLEVELEQAVPYFLNLVAFPSYYPLNEKFVKEKGDKYGLESDTTVYNGPFVLTDWKHEQGWKLKKNDQYWDKKTVKLDEINYSVVKEPATNVNLYDSGQIDFSLLTGEFVDKYRNNKEEYGVYNEPSTFFIRLNQKRGGQDTPLKSKKLREAIALSIDKKNLTNVILNDGSKPADYLVPKGLAAGPDGKDFQETFKNGVKPDAKKAAAAWEEAKKELGKDQVTIEFLNYDTGNAKKVGEYVKDQIEKNLKGVTVNIKLQPFKQKLKLESDQDYDISYGGWSPDYADPMTYLDMFESKHSHNQMSFSDQKYDEIIKKAGGELMTDAKKRWEELGKAEELLLEEDVALVPLYQSARSYVMKPHVKGVVKHNISPEYSYKWAYVTE 6npo A 2.40 BS02 ZN A 1 D279 H539 D236 H496 EKLAAKQVFNKTENQEIPTMDTSKSTDTLGSQILGNTMEGLYRLDKENKPIPAAAESSTKSEDGKKYTFKLRKDAKWSNGDSVTAKDFVFAWQRLLDPKTAAEYAFIAFPIKNAEAVNKGEKPVTELGVKAVDDLTLEVELEQAVPYFLNLVAFPSYYPLNEKFVKEKGDKYGLESDTTVYNGPFVLTDWKHEQGWKLKKNDQYWDKKTVKLDEINYSVVKEPATNVNLYDSGQIDFSLLTGEFVDKYRNNKEEYGVYNEPSTFFIRLNQKRGGQDTPLKSKKLREAIALSIDKKNLTNVILNDGSKPADYLVPKGLAAGPDGKDFQETFKNGVKPDAKKAAAAWEEAKKELGKDQVTIEFLNYDTGNAKKVGEYVKDQIEKNLKGVTVNIKLQPFKQKLKLESDQDYDISYGGWSPDYADPMTYLDMFESKHSHNQMSFSDQKYDEIIKKAGGELMTDAKKRWEELGKAEELLLEEDVALVPLYQSARSYVMKPHVKGVVKHNISPEYSYKWAYVTE 6nrq B 1.80 BS01 FUC A 1 V90 T92 H93 V52 T54 H55 30688651 AFQPEFVESISNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAIQAIHENVITHNPRVTVSHLDQNTWNLHIKAVSEEDRGGYMCQLNTDPMKSQIGFLDVVI 6nrq C 1.80 BS01 FUC C 1 N62 T64 N15 T17 30688651 GSWNEPYFDLTMPRNITSLVGKSAYLGCRVKHLGNKTVAWIRHRDLHILTVGTYTYTTDQRFQTSYHRDIDEWTLQIKWAQQRDAGVYECQISTQPVRSYSVNLNIVH 6nrw B 2.40 BS01 FUC B 1 N51 T53 Y138 D140 N14 T16 Y101 D103 30688651 SRIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDPMKSQMGYLDVV 6ns0 A 2.20 BS01 LYS A 1 G225 A226 S247 E249 R271 E287 Y289 N441 A442 Y443 E445 G491 G493 G222 A223 S244 E246 R268 E284 Y286 N438 A439 Y440 E442 G488 G490 6.1.1.6 EVEYLQHEDYLYRTSKLKEIRDLGINPYPYQYTDCLEVQEIRNQFVDNELGDSEAAFRKETPKVRFAGRLVLFRSMGKNAFGQILDNDAKIQVMFNRDFSAVAGLAADAGISPIKFIEKKLDLGDILGLEGYLFFTHSGELTVLVETVTLLCKSLISLPDKHAGLADKEIRYRKRWADLISSEDVRKTFLTRSRILKLIREYMDQQSFLEVETPILQTVYGGAEATPFVTTLQALHAEMFLRISLEIALKKLLVGGMSRVYEIGKVFRNEGIDRTHNPEFTMIEAYAAYWDYNDVMKCVENLVEYIVRALNNGETQVQYSHLKSGPQVVDFKAPWIRMTMKESISVYGGVDVDLHADHELRKILETQTSLPEKTYVHASRGELIALLFDELVCDKLIAPHHITDHPLETTPLCKTLRSGDETLVERFESFCLGKELCNAYSELNDPLQQRKLLEEQMRKKALNPDSEYHPIDEEFLEALCQGMPPAGGFGIGIDRLVMMLTDAASIRDVLFFPVMRR 6ns0 A 2.20 BS02 KRS A 1 R271 E273 H279 N280 F283 M285 L439 C440 N441 G493 I494 G495 R498 I509 R268 E270 H276 N277 F280 M282 L436 C437 N438 G490 I491 G492 R495 I506 6.1.1.6 EVEYLQHEDYLYRTSKLKEIRDLGINPYPYQYTDCLEVQEIRNQFVDNELGDSEAAFRKETPKVRFAGRLVLFRSMGKNAFGQILDNDAKIQVMFNRDFSAVAGLAADAGISPIKFIEKKLDLGDILGLEGYLFFTHSGELTVLVETVTLLCKSLISLPDKHAGLADKEIRYRKRWADLISSEDVRKTFLTRSRILKLIREYMDQQSFLEVETPILQTVYGGAEATPFVTTLQALHAEMFLRISLEIALKKLLVGGMSRVYEIGKVFRNEGIDRTHNPEFTMIEAYAAYWDYNDVMKCVENLVEYIVRALNNGETQVQYSHLKSGPQVVDFKAPWIRMTMKESISVYGGVDVDLHADHELRKILETQTSLPEKTYVHASRGELIALLFDELVCDKLIAPHHITDHPLETTPLCKTLRSGDETLVERFESFCLGKELCNAYSELNDPLQQRKLLEEQMRKKALNPDSEYHPIDEEFLEALCQGMPPAGGFGIGIDRLVMMLTDAASIRDVLFFPVMRR 6qbs A 1.70 BS01 HVW A 1 Q19 G23 C25 W26 E59 N60 D61 G64 G65 G66 Y67 M68 A134 L160 N161 H162 A163 Q19 G23 C25 W26 E59 N60 D61 G64 G65 G66 Y67 M68 A134 L160 N161 H162 A163 3.4.22.38 30689386 APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM 6qbs A 1.70 BS03 HVW B 1 Y67 L209 Y67 L209 3.4.22.38 30689386 APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM 6qeb A BS02 AZM A 1 H94 H96 H119 N243 H94 H96 H119 N243 4.2.1.1 30688395 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 6qh9 A 2.27 BS01 J2N A 1 D189 S190 Q192 G193 S195 V213 G216 N217 I218 C220 D170 S171 Q173 G174 S176 V190 G193 N194 I195 C197 3.4.21.- 30691925 LVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLGQQESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSAQTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQA 6qh9 A 2.27 BS02 J3B A 1 D189 S190 Q192 G193 D194 S195 V213 W215 G216 N217 I218 C220 D170 S171 Q173 G174 D175 S176 V190 W192 G193 N194 I195 C197 3.4.21.- 30691925 LVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLGQQESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSAQTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQA 6qh9 B 2.27 BS01 J2N B 1 L41 C42 H57 D189 S190 C191 G193 D194 S195 V213 W215 G216 N217 L25 C26 H41 D170 S171 C172 G174 D175 S176 V190 W192 G193 N194 3.4.21.- 30691925 LVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLGQQESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSAQTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQ 6qha A 1.82 BS01 J2Q A 1 L41 C42 H57 D189 S190 C191 Q192 S195 V213 W215 G216 N217 G226 L25 C26 H41 D170 S171 C172 Q173 S176 V190 W192 G193 N194 G204 3.4.21.- 30691925 LVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLGQQESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSAQTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQA 6qhb B 1.84 BS01 J2W B 1 H57 D189 S190 C191 Q192 S195 V213 W215 G216 N217 I218 C220 G226 H41 D170 S171 C172 Q173 S176 V190 W192 G193 N194 I195 C197 G204 3.4.21.- 30691925 LVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLGQQESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSAQTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQA 6qhc B 1.87 BS01 135 B 1 D189 S190 Q192 G193 S195 V213 G216 N217 G226 D170 S171 Q173 G174 S176 V190 G193 N194 G204 3.4.21.- 30691925 LVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLGQQESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSAQTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQA