5kw2 A 2.76 BS01 6XQ A 1 P40 Y44 Y91 G95 A99 A102 A103 L106 Y114 S123 V126 I130 L133 L189 L193 P194 I197 P32 Y36 Y83 G87 A91 A94 A95 L98 Y106 S115 V118 I122 L125 L160 L164 P165 I168 3.2.1.17 LPPQLSFGLYVAAFALGFPLNVLAIRGATATPSAVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFAPLYAGGGFLAALSAARYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCFVGCLRALARGSNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYGSLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGY 5los A 2.00 BS01 ZN A 1 H31 H92 H17 H78 AQHYAQAIHHEGLARHHTTVAEDHRQTANLHDNRIKAAKARYNAGLDPNGLTSAQKHQIERDHHLSLAAQAERHAATHNREAAYHRLHS 5mh5 A 1.40 BS01 MG A 1 T132 A134 T132 A134 1.1.1.- MHIERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGHRDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGYMLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGVVDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDELTNRVV 5mh5 A 1.40 BS02 MG A 2 F212 E213 M215 D243 F212 E213 M215 D243 1.1.1.- MHIERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGHRDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGYMLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGVVDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDELTNRVV 5mh5 A 1.40 BS03 7N5 A 1 R66 A67 G68 H91 R226 H274 A277 Y282 R66 A67 G68 H91 R226 H274 A277 Y282 1.1.1.- MHIERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGHRDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGYMLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGVVDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDELTNRVV 5mh5 A 1.40 BS04 NAP A 1 A67 G68 T88 H91 G142 L143 G144 T145 L146 V164 R165 R166 S167 P180 A196 T197 P198 T203 V224 A225 R226 D250 H274 S276 A277 A67 G68 T88 H91 G142 L143 G144 T145 L146 V164 R165 R166 S167 P180 A196 T197 P198 T203 V224 A225 R226 D250 H274 S276 A277 1.1.1.- MHIERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGHRDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGYMLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGVVDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDELTNRVV 5mh5 B 1.40 BS01 MG B 1 E213 T214 E213 T214 1.1.1.- MHIERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGHRDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGYMLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGVVDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDELTNRVV 5mh5 B 1.40 BS02 MG B 2 P170 V177 P170 V177 1.1.1.- MHIERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGHRDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGYMLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGVVDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDELTNRVV 5mh5 B 1.40 BS05 7N5 B 1 R66 A67 G68 H91 R226 H274 Y282 R66 A67 G68 H91 R226 H274 Y282 1.1.1.- MHIERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGHRDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGYMLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGVVDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDELTNRVV 5mh5 B 1.40 BS06 NAP B 1 A67 G68 T88 H91 L143 G144 T145 L146 V164 R165 R166 S167 P180 A196 T197 P198 T203 V224 A225 R226 D250 V251 H274 S276 A67 G68 T88 H91 L143 G144 T145 L146 V164 R165 R166 S167 P180 A196 T197 P198 T203 V224 A225 R226 D250 V251 H274 S276 1.1.1.- MHIERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGHRDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGYMLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGVVDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDELTNRVV 5mo3 H 1.69 BS01 III A 1 E50 F52 S57 Y59 Y101 F105 E49 F51 S56 Y58 Y100 F104 VQLQQSGPELVKPGTSVKMPCKASGYIFTDYVISWVKQRTGQGLEWIGEIFPRSGSTYYNEKFKGKATLTADKSSNTAYMQLSSVTSEDSAVYFCARDYYGTSFAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD 5mo3 L 1.69 BS01 III A 1 N31 Y38 S97 F98 Y99 L100 R101 N31 Y38 S97 F98 Y99 L100 R101 DIVMSQSPSSLAVSAGEKVTMSCKSSQSLLNSRTRKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCKQSFYLRTFGGGTKLDIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVRWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE 5mo3 L 1.69 BS02 TRE L 1 K147 D148 I149 W168 K147 D148 I149 W168 DIVMSQSPSSLAVSAGEKVTMSCKSSQSLLNSRTRKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCKQSFYLRTFGGGTKLDIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVRWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE 5mp1 H 3.10 BS01 III A 1 F52 S57 Y59 Y101 F105 F51 S56 Y58 Y100 F104 VQLQQSGPELVKPGTSVKMPCKASGYIFTDYVISWVKQRTGQGLEWIGEIFPRSGSTYYNEKFKGKATLTADKSSNTAYMQLSSVTSEDSAVYFCARDYYGTSFAMDYWGQGTSVTVSSAKTTPPSVYPLAPGNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD 5mp1 C 3.10 BS01 III B 1 V33 E50 F52 S57 Y59 Y101 F105 V32 E49 F51 S56 Y58 Y100 F104 VQLQQSGPELVKPGTSVKMPCKASGYIFTDYVISWVKQRTGQGLEWIGEIFPRSGSTYYNEKFKGKATLTADKSSNTAYMQLSSVTSEDSAVYFCARDYYGTSFAMDYWGQGTSVTVSSAKTTPPSVYPLAPGNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR 5mp1 G 3.10 BS01 III E 1 Y38 S97 F98 Y99 L100 R101 Y38 S97 F98 Y99 L100 R101 DIVMSQSPSSLAVSAGEKVTMSCKSSQSLLNSRTRKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCKQSFYLRTFGGGTKLDIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVRWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE 5mp1 K 3.10 BS01 III I 1 S32 Y38 S97 F98 Y99 L100 R101 S32 Y38 S97 F98 Y99 L100 R101 DIVMSQSPSSLAVSAGEKVTMSCKSSQSLLNSRTRKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCKQSFYLRTFGGGTKLDIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVRWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE 5mp3 H 2.75 BS01 III D 1 V33 E50 F52 Y59 Y101 F105 V32 E49 F51 Y58 Y100 F104 VQLQQSGPELVKPGTSVKMPCKASGYIFTDYVISWVKQRTGQGLEWIGEIFPRSGSTYYNEKFKGKATLTADKSSNTAYMQLSSVTSEDSAVYFCARDYYGTSFAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR 5mp3 L 2.75 BS01 III D 1 T34 Y38 S97 F98 Y99 L100 R101 T34 Y38 S97 F98 Y99 L100 R101 DIVMSQSPSSLAVSAGEKVTMSCKSSQSLLNSRTRKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCKQSFYLRTFGGGTKLDIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVRWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE 5mp3 B 2.75 BS01 III C 1 N31 Y38 S97 F98 Y99 L100 N31 Y38 S97 F98 Y99 L100 DIVMSQSPSSLAVSAGEKVTMSCKSSQSLLNSRTRKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCKQSFYLRTFGGGTKLDIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVRWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE 5mp5 B 2.31 BS01 III K 1 N31 S97 F98 Y99 L100 R101 N31 S97 F98 Y99 L100 R101 DIVMSQSPSSLAVSAGEKVTMSCKSSQSLLNSRTRKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCKQSFYLRTFGGGTKLDIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVRWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN 5mp5 F 2.31 BS01 III I 1 N31 Y38 S97 F98 L100 R101 N31 Y38 S97 F98 L100 R101 DIVMSQSPSSLAVSAGEKVTMSCKSSQSLLNSRTRKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCKQSFYLRTFGGGTKLDIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVRWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR 5mth H 1.73 BS01 TRE H 1 V2 Q3 Y109 W110 G111 Q112 V1 Q2 Y108 W109 G110 Q111 VQLQQSGPELVKPGTSVKMPCKASGYIFTDYVISWVKQRTGQGLEWIGEIFPRSGSTYYNEKFKGKATLTADKSSNTAYMQLSSVTSEDSAVYFCARDYYGTSFAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD 5mth H 1.73 BS02 TRE H 2 R40 G44 E46 R39 G43 E45 VQLQQSGPELVKPGTSVKMPCKASGYIFTDYVISWVKQRTGQGLEWIGEIFPRSGSTYYNEKFKGKATLTADKSSNTAYMQLSSVTSEDSAVYFCARDYYGTSFAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD 5mth H 1.73 BS03 TRE L 1 V170 H171 T172 V169 H170 T171 VQLQQSGPELVKPGTSVKMPCKASGYIFTDYVISWVKQRTGQGLEWIGEIFPRSGSTYYNEKFKGKATLTADKSSNTAYMQLSSVTSEDSAVYFCARDYYGTSFAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD 5mth L 1.73 BS01 TRE L 1 P46 L89 D170 Q171 D172 S173 P46 L89 D170 Q171 D172 S173 DIVMSQSPSSLAVSAGEKVTMSCKSSQSLLNSRTRKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCKQSFYLRTFGGGTKLDIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVRWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 5nap A 2.17 BS01 DZ7 A 1 Y70 W84 Y121 E199 W279 F330 F331 Y334 H440 Y67 W81 Y118 E196 W276 F327 F328 Y331 H437 3.1.1.7 29651884 SELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNMRFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYLNIWVPSPRPKSTTVMVWIYGGGFYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALHGSQEAPGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGGASVGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRRRAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEWNVLPFDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGVNKDEGSFFLLYGAPGFSKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHNVICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYEIEFVFGLPLVKELNYTAEEEALSRRIMHYWATFAKTGNPNEPHSQESKWPLFTTKEQKFIDLNTEPMKVHQRLRVQMCVFWNQFLPKLLNAT 5nau A 2.25 BS01 DZ0 A 1 W84 Y121 E199 W279 F330 F331 Y334 H440 W81 Y118 E196 W276 F327 F328 Y331 H437 3.1.1.7 29651884 SELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNMRFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYLNIWVPSPRPKSTTVMVWIYGGGFYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALHGSQEAPGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGGASVGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRRRAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEWNVLPFDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGVNKDEGSFFLLYGAPGFSKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHNVICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYEIEFVFGLPLVKELNYTAEEEALSRRIMHYWATFAKTGNPNEPHSQESKWPLFTTKEQKFIDLNTEPMKVHQRLRVQMCVFWNQFLPKLLNAT 5npz A 1.43 BS01 III C 1 Y8 Y60 R63 N64 N67 V68 S71 I74 V77 N78 T81 L82 Y85 W98 Y100 S144 K147 W148 A153 H156 W157 Y160 T164 S168 Y172 Y8 Y60 R63 N64 N67 V68 S71 I74 V77 N78 T81 L82 Y85 W98 Y100 S144 K147 W148 A153 H156 W157 Y160 T164 S168 Y172 MGPHSLSYFSTAVSRPDRGDSRFIAVGYVDDTQFVRFDSDAPNPRMEPRAPWIQQEGQEYWDRNTRNVMGSAQINRVNLKTLRGYYNQSEAGSHTLQWMYGCYLGPDGLLLRGYDQFAYDGADYLALNEDLRSWTAADMAAQISKRKWEAADAAEHWRSYLQGTCVESLRRYLQMGKDTLQRAEPPKTHVTRHPSSDLGVTLRCWALGFHPKEISLTWQREGQDQSQDMELVETRPSGDGTFQKWAALVVPPGEEQSYTCHVQHEGLQEPLTLRWDP 5nw7 A 1.85 BS02 9C2 A 1 Y16 W18 E48 K100 L108 S109 Q111 H113 K136 E138 H285 Y287 E294 R304 K310 Y15 W17 E47 K99 L107 S108 Q110 H112 K135 E137 H284 Y286 E293 R303 K309 5.3.1.8 29687459 SSEKLFRIQCGYQNYDWGKIGSSSAVAQFVHNSDPSITIDETKPYAELWMGTHPSVPSKAIDLNNQTLRDLVTAKPQEYLGESIITKFGSSKELPFLFKVLSIEKVLSIQAHPDKKLGAQLHAADPKNYPDDNHKPEMAIAVTDFEGFCGFKPLDQLAKTLATVPELNEIIGQELVDEFISGIKLPAEVGSQDDVNNRKLLQKVFGKLMNTDDDVIKQQTAKLLERTDREPQVFKDIDSRLPELIQRLNKQFPNDIGLFCGCLLLNHVGLNKGEAMFLQAKDPHAYISGDIIECMAASDNVVRAGFTPKFKDVKNLVEMLTYSYESVEKQKMPLQEFPRSKGDAVKSVLYDPPIAEFSVLQTIFDKSKGGKQVIEGLNGPSIVIATNGKGTIQITGDDSTKQKIDTGYVFFVAPGSSIELTADSANQDQDFTTYRAFVEA 5nwb A 1.60 BS02 9C5 A 1 H1031 G1032 H1048 A1049 Y1050 Y1060 A1062 K1067 S1068 Y1071 I1075 H80 G81 H97 A98 Y99 Y109 A111 K116 S117 Y120 I124 2.4.2.30 29374194 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSA 5nwb B 1.60 BS02 9C5 B 1 H1031 G1032 F1035 A1049 Y1050 Y1060 K1067 S1068 Y1071 I1075 H80 G81 F84 A98 Y99 Y109 K116 S117 Y120 I124 2.4.2.30 29374194 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAM 5o9o A 1.90 BS01 9PB A 1 Q62 Y107 D132 S134 E135 P136 S139 I140 N141 R142 V177 Y244 E275 Y307 Y316 Q34 Y65 D90 S92 E93 P94 S97 I98 N99 R100 V135 Y202 E233 Y265 Y274 2.4.1.- 29164827 SFEKTPAIKIVGNKFFDSESGEQFFIKGIAYQLQTSYIDALADPKICLRDIPFLKMLGVNTLRVYAIDPTKSHDICMEALSAEGMYVLLDLSEPDISINRENPSWDVHIFERYKSVIDAMSSFPNLLGYFAGNEVTNDHTNTFASPFVKAAIRDAKEYISHSNHRKIPVGYSTNDDAMTRDNLARYFVCGDVKADFYGINMYEWCGYSTYGTSGYRERTKEFEGYPIPVFFSEFGCNLVRPRPFTEVSALYGNKMSSVWSGGLAYMYFEEENEYGVVKINDNDGVDILPDFKNLKKEFAKADPKGITEEEYESVECPHIAVGVWEANEKLPETPDRSKCACLDEILPCEIVPFGKYEEYFSYLCSKVDCSDILANGKTGEYGEFSDCSVEQKLSLQLSKLYCKIGANDRHCPLNDKNVYFNLESLQPC 5o9p A 1.75 BS01 9P8 A 1 Y107 D132 S134 P136 S139 I140 N141 R142 N175 V177 Y244 E275 Y307 Y316 Y71 D96 S98 P100 S103 I104 N105 R106 N139 V141 Y208 E239 Y271 Y280 2.4.1.- 29164827 SFEKTPAIKIVGNKFFDSESGEQFFIKGIAYQLQRSGAFETSYIDALADPKICLRDIPFLKMLGVNTLRVYAIDPTKSHDICMEALSAEGMYVLLDLSEPDISINRENPSWDVHIFERYKSVIDAMSSFPNLLGYFAGNEVTNDHTNTFASPFVKAAIRDAKEYISHSNHRKIPVGYSTNDDAMTRDNLARYFVCGDVKADFYGINMYEWCGYSTYGTSGYRERTKEFEGYPIPVFFSEFGCNLVRPRPFTEVSALYGNKMSSVWSGGLAYMYFEEENEYGVVKINDNDGVDILPDFKNLKKEFAKADPKGITEEEYLTESVECPHIAVGVWEANEKLPETPDRSKCACLDEILPCEIVPGKYEEYFSYLCSKVDCSDILANGKTGEYGEFSDCSVEQKLSLQLSKLYCKIGANDRHCPLNDKNVYFNLESLQPC 5o9r A 1.70 BS01 BGC A 1 E245 C247 S255 L280 E204 C206 S214 L239 2.4.1.- 29164827 SFEKTPAIKIVGNKFFDSESGEQFFIKGIAYQLQRSSYIDALADPKICLRDIPFLKMLGVNTLRVYAIDPTKSHDICMEALSAEGMYVLLDLSEPDISINRENPSWDVHIFERYKSVIDAMSSFPNLLGYFAGNEVTNDHTNTFASPFVKAAIRDAKEYISHSNHRKIPVGYSTNDDAMTRDNLARYFVCGDVKADFYGINMYEWCGYSTYGTSGYRERTKEFEGYPIPVFFSEFGCNLVRPRPFTEVSALYGNKMSSVWSGGLAYMYFEEENEYGVVKINDNDGVDILPDFKNLKKEFAKADPKGITEEEYLTSVECPHIAVGVWEANEKLPETPDRSKCACLDEILPCEIVPGKYEEYFSYLCSKVDCSDILANGKTGEYGEFSDCSVEQKLSLQLSKLYCKIGANDRHCPLNDKNVYFNLESLQPC 5o9r A 1.70 BS04 9PK A 1 Q60 Y107 S134 P136 S139 I140 R142 V177 Y244 E275 Y307 Y316 Q32 Y66 S93 P95 S98 I99 R101 V136 Y203 E234 Y266 Y275 2.4.1.- 29164827 SFEKTPAIKIVGNKFFDSESGEQFFIKGIAYQLQRSSYIDALADPKICLRDIPFLKMLGVNTLRVYAIDPTKSHDICMEALSAEGMYVLLDLSEPDISINRENPSWDVHIFERYKSVIDAMSSFPNLLGYFAGNEVTNDHTNTFASPFVKAAIRDAKEYISHSNHRKIPVGYSTNDDAMTRDNLARYFVCGDVKADFYGINMYEWCGYSTYGTSGYRERTKEFEGYPIPVFFSEFGCNLVRPRPFTEVSALYGNKMSSVWSGGLAYMYFEEENEYGVVKINDNDGVDILPDFKNLKKEFAKADPKGITEEEYLTSVECPHIAVGVWEANEKLPETPDRSKCACLDEILPCEIVPGKYEEYFSYLCSKVDCSDILANGKTGEYGEFSDCSVEQKLSLQLSKLYCKIGANDRHCPLNDKNVYFNLESLQPC 5oa2 C 2.15 BS02 BGC C 2 D217 A219 R222 D174 A176 R179 2.4.1.- 29164827 SFEKTPAIKIVGNKFFDSESGEQFFIKGIAYQLQSYIDALADPKICLRDIPFLKMLGVNTLRVYAIDPTKSHDICMEALSAEGMYVLLDLSEPDISINRENPSWDVHIFERYKSVIDAMSSFPNLLGYFAGNEVTNDHTNTFASPFVKAAIRDAKEYISHSNHRKIPVGYSTNDDAMTRDNLARYFVCGDVKADFYGINMYEWCGYSTYGTSGYRERTKEFEGYPIPVFFSEFGCNLVRPRPFTEVSALYGNKMSSVWSGGLAYMYFEEENEYGVVKINDNDGVDILPDFKNLKKEFAKADPKGITEEEYLTESVECPHIAVGVWEANEKLPETPDRSKCACLDEILPCEIVPFESGKYEEYFSYLCSKVDCSDILANGKTGEYGEFSDCSVEQKLSLQLSKLYCKIGANDRHCPLNDKNVYFNLESLQPCKNVF 5osy A 2.06 BS01 AJQ A 1 R54 D59 I61 E85 K142 Y143 W175 E185 P204 D205 L206 K207 Y217 I219 H268 S272 Y273 P288 R294 R18 D23 I25 E49 K106 Y107 W139 E149 P168 D169 L170 K171 Y181 I183 H232 S236 Y237 P252 R258 3.6.1.59 29676910 SAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQ 5osy B 2.06 BS01 AJQ B 1 W175 E185 L206 S272 Y273 W130 E140 L161 S227 Y228 3.6.1.59 29676910 VRLPFSGFRLQKVLRESARDKIIFLHGKVNEGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQ 5owt A 2.20 BS01 F37 A 1 H1031 G1032 P1034 F1035 R1047 H1048 A1049 Y1050 Y1060 K1067 S1068 Y1071 I1075 E1138 H80 G81 P83 F84 R96 H97 A98 Y99 Y109 K116 S117 Y120 I124 E180 2.4.2.30 29374194 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5vm0 A 1.79 BS01 9EG A 1 E3 V4 A26 T30 Y31 T32 Y34 M36 R74 K79 T80 T100 R101 A102 P114 I115 E2 V3 A25 T29 Y30 T31 Y33 M35 R73 K78 T79 T99 R100 A101 P113 I114 AEVQLVESGGGLVQTGDSLRLSCAASGRTYTPYAMAWFRQAPGKEREFVAGIGGIDGTAAYADSVRGRATISRDSAKKTVYLQMNSLKPEDTAVYSCATRASMQVLTSPRVYPIWGRGTQVTVSS 5vm0 B 1.79 BS01 9EG B 1 E3 V4 A26 R29 T30 Y31 T32 Y34 M36 K79 T80 T100 R101 A102 I115 E2 V3 A25 R28 T29 Y30 T31 Y33 M35 K78 T79 T99 R100 A101 I114 AEVQLVESGGGLVQTGDSLRLSCAASGRTYTPYAMAWFRQAPGKEREFVAGIGGIDGTAAYADSVRGRATISRDSAKKTVYLQMNSLKPEDTAVYSCATRASMQVLTSPRVYPIWGRGTQVTVSSPG 5vm6 A 1.50 BS01 9EG A 1 V4 L6 C24 G26 R28 R29 A30 T34 V36 N79 G80 S100 Y120 V1 L3 C21 G23 R25 R26 A27 T31 V33 N76 G77 S97 Y117 VKLQQSGGGMVQTGDSLRLSCVGSRRALSSTIVGWFRQIPGKEREFVGGIAWSSSDTWYADSVKGRFTISKDDAANGVHLQMSSLKPEDTAVYYCASALRRPGSDASDYTRIPDYPYWGQGTQVTVSSH 5vnc A 2.98 BS01 UDP A 1 G319 R320 K326 F480 L481 Y492 E509 G512 Y513 T514 E517 G318 R319 K325 F479 L480 Y491 E508 G511 Y512 T513 E516 2.4.1.11 SRDLQNHLLFETATEVANRVGGIYSVLKSKAPITVAQYKDHYHLIGPLNKATYQNEVDILDWKKPEAFSDEMRPVQHALQTMESRGVHFVYGRWLIEGAPKVILFDLDSVRGYSNEWKGDLWSLVGIPSPENDFETNDAILLGYTVAWFLGEVAHLDSQHAIVAHFHQWLAGVALPLCRKRRIDVVTIFTTHATLLGRYLCASGSFDFYNCLESVDVDHEAGRFGIYHRYCIERAAAHSADVFTTVSQITAFEAEHLLKRKPDGILPNGLNVIKFQAFHEFQNLHALKKEKINDFVRGHFHGCFDFDLDNTLYFFIAGRYEYKNKGADMFIEALARLNYRLKVSGSKKTVVAFIVMPAKNNSFTVEALKGQAEVRALENTVHEVTTSIGKRIFDHAIRYPHNGLTTELPTDLGELLKSSDKVMLKRRILALRRPEGQLPPIVTHNMVDDANDLILNKIRQVQLFNSPSDRVKMIFHPEFLNANNPILGLDYDEFVRGCHLGVFPSYYEPWGYTPAECTVMGVPSITTNVSGFGSYMEDLIETNQAKDYGIYIVDRRFKAPDESVEQLVDYMEEFVKKTRRQRINQRNRTERLSDLLDWKRMGLEYVKARQLALRRGYPDQFRELVGEELNDSNMDALA 5w7x D 2.01 BS01 III H 1 R27 G28 P29 G32 I33 T34 K36 S39 R40 H58 R25 G26 P27 G30 I31 T32 K34 S37 R38 H56 4.2.99.18 29059378 GGFELQPRDGGPRVALAPGETVIGRGPLLGITDKRVSRRHAILEVAGGQLRIKPIHTNPCFYQSSEKSQLLPLKPNLWCYLNPGDSFSLLVDKYIFRILSIP 5w7x A 2.01 BS01 III E 1 R27 G28 P29 G32 I33 T34 K36 V38 S39 R40 H58 N60 R25 G26 P27 G30 I31 T32 K34 V36 S37 R38 H56 N58 4.2.99.18 29059378 GGFELQPRDGGPRVALAPGETVIGRGPLLGITDKRVSRRHAILEVAGGQLRIKPIHTNPCFYQSSEKSQLLPLKPNLWCYLNPGDSFSLLVDKYIFRILSI 5w7x B 2.01 BS01 III F 1 R27 G28 P29 G32 I33 K36 R37 S39 R40 H58 R25 G26 P27 G30 I31 K34 R35 S37 R38 H56 4.2.99.18 29059378 GGFELQPRDGGPRVALAPGETVIGRGPLLGITDKRVSRRHAILEVAGGQLRIKPIHTNPCFYQSSEKSQLLPLKPNLWCYLNPGDSFSLLVDKYIFRILSIP 5w7x C 2.01 BS01 III G 1 R27 G28 P29 I33 K36 S39 R40 H58 R25 G26 P27 I31 K34 S37 R38 H56 4.2.99.18 29059378 GGFELQPRDGGPRVALAPGETVIGRGPLLGITDKRVSRRHAILEVAGGQLRIKPIHTNPCFYQSSEKSQLLPLKPNLWCYLNPGDSFSLLVDKYIFRILSIP 5wa6 A 2.25 BS03 KU7 A 1 A20 Y24 K34 I38 H41 E80 D108 E119 I120 A24 Y28 K38 I42 H45 E65 D93 E104 I105 RGSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE 5wbg A 2.99 BS01 HEM A 1 R98 I114 W121 R125 M132 A298 G299 T302 Q357 L363 V367 H369 L392 P428 F429 S430 R434 C436 L437 G438 A442 R71 I87 W94 R98 M105 A270 G271 T274 Q329 L335 V339 H341 L364 P400 F401 S402 R406 C408 L409 G410 A414 1.14.13.- 29596329 GKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 5wbg A 2.99 BS02 9ZJ A 1 I101 F108 I114 F115 F206 F297 A298 E301 T302 L363 V477 I74 F81 I87 F88 F179 F269 A270 E273 T274 L335 V449 1.14.13.- 29596329 GKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 5wbg B 2.99 BS01 HEM B 1 R98 V113 I114 W121 R125 M132 A298 G299 T302 T303 T306 H369 L392 P428 F429 S430 R434 C436 L437 G438 A442 R72 V87 I88 W95 R99 M106 A271 G272 T275 T276 T279 H342 L365 P401 F402 S403 R407 C409 L410 G411 A415 1.14.13.- 29596329 KGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 5wbg B 2.99 BS03 CM5 B 1 L39 F220 G222 F223 L13 F194 G196 F197 1.14.13.- 29596329 KGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 5wbg D 2.99 BS01 HEM D 1 R98 I114 W121 R125 A298 G299 T302 L363 H369 L392 P428 F429 S430 R434 C436 L437 G438 A442 R72 I88 W95 R99 A271 G272 T275 L336 H342 L365 P401 F402 S403 R407 C409 L410 G411 A415 1.14.13.- 29596329 KGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 5wbg D 2.99 BS02 9ZJ D 1 I101 F108 I114 F115 F206 F297 A298 E301 L363 V367 V477 I75 F82 I88 F89 F180 F270 A271 E274 L336 V340 V450 1.14.13.- 29596329 KGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 5wbg E 2.99 BS01 HEM E 1 R98 W121 R125 I179 A298 G299 T302 T306 H369 L392 P428 F429 S430 R434 C436 L437 G438 A442 R71 W94 R98 I152 A270 G271 T274 T278 H341 L364 P400 F401 S402 R406 C408 L409 G410 A414 1.14.13.- 29596329 GKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 5wbg F 2.99 BS01 HEM F 1 R98 I114 W121 R125 A298 G299 T302 H369 P428 F429 S430 R434 C436 L437 G438 A442 R72 I88 W95 R99 A271 G272 T275 H342 P401 F402 S403 R407 C409 L410 G411 A415 1.14.13.- 29596329 KGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 5wbg F 2.99 BS02 CM5 F 1 L40 P72 F220 F223 L14 P46 F194 F197 1.14.13.- 29596329 KGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 5x9d A 2.10 BS01 80F A 1 F6 G7 Y8 G9 N10 V11 T37 R38 V72 S73 S74 P82 T100 N101 K102 G127 S131 N155 G156 T157 G182 Y183 A184 E185 E186 D191 D196 K200 A283 G284 A288 F6 G7 Y8 G9 N10 V11 T37 R38 V72 S73 S74 P82 T100 N101 K102 G127 S131 N155 G156 T157 G182 Y183 A184 E185 E186 D191 D196 K200 A281 G282 A286 1.1.1.3 29636528 MKLLLFGYGNVGKAFRKLLHEKRSPELNDVIIGGIVTRRGIMLQDKEDFTPDLEGDVFKAFEKIKPDIIVDVSSANYNNGEPSLSLYKEAIKDGVNIITTNKAPLALAFNEIFSLARSKGVKIGFQGTVMSGTPSINLYRVLPGSRVIKIRGILNGTTNFILTLMNKGVSFEEALKEAQRRGYAEEDPTLDINGFDAAAKITILANFMIGNSVTIKDVKFEGINRDPKNEKIKLIAYADEKEVWVKPLPISQDPLYNVDGVENALEITTDIQSILIRGPGAGPVNAAYGALSDLILLKRDCL 5xbt A 2.50 BS01 C2E A 1 S0 M1 R31 G33 S34 D35 N36 Y40 S1 M2 R32 G34 S35 D36 N37 Y41 SMLTIGQLARIFEISTKTLRHYDAIGLFVPARTGSDNGYRYYQPEQIEQLSRILALRRLDVPLEAIDRLKRDGALDDPQRLRHFLQRHQHTLREEISARQRLLAELDRTLATLAHWRIRNMHARIVERPAFSVVGMEYFGSAPGDTIGQLWERFIPREHEIAGKHDPEVSYGICAQQPNGEFHYVAGFEVQEGWPVPEGMVRFQVPAQKYAVFTHKGTAPQIAESFQAIYSHLLAERGLEPKAGVDFEYYDQRFRGPLDPNSQVDLYIPIY 5xbt A 2.50 BS02 C2E A 2 E63 A64 R67 F83 R86 E64 A65 R68 F84 R87 SMLTIGQLARIFEISTKTLRHYDAIGLFVPARTGSDNGYRYYQPEQIEQLSRILALRRLDVPLEAIDRLKRDGALDDPQRLRHFLQRHQHTLREEISARQRLLAELDRTLATLAHWRIRNMHARIVERPAFSVVGMEYFGSAPGDTIGQLWERFIPREHEIAGKHDPEVSYGICAQQPNGEFHYVAGFEVQEGWPVPEGMVRFQVPAQKYAVFTHKGTAPQIAESFQAIYSHLLAERGLEPKAGVDFEYYDQRFRGPLDPNSQVDLYIPIY 5xbt B 2.50 BS02 C2E B 2 E63 A64 R67 R70 F83 R86 E64 A65 R68 R71 F84 R87 SMLTIGQLARIFEISTKTLRHYDAIGLFVPARTGSDNGYRYYQPEQIEQLSRILALRRLDVPLEAIDRLKRDGALDDPQRLRHFLQRHQHTLREEISARQRLLAELDRTLATLAHWRIRNMHARIVERPAFSVVGMEYFGSAPGDTIGQLWERFIPREHEIAGKHDPEVSYGICAQQPNGEFHYVAGFEVQEGWPVPEGMVRFQVPAQKYAVFTHKGTAPQIAESFQAIYSHLLAERGLEPKAGVDFEYYDQRFRGPLDPNSQVDLYIPIY 5xe5 A 2.17 BS01 MG A 1 H133 E164 H269 E273 H123 E154 H259 E263 VHPITYYPVDTQRLVRSNAERIRHKPYAHYFNPDVAVPEEVFAALKAPLEPEQVLGTSSTELNRLLEPGYLEGETGYCGLPDGAGYTSSLVRFPGATPEMFRWWFWWHSFEPERYSLWHPWCHADIWRTDPETETAPNLTDEQRYVGSTHHINEYIGQDPLDIEITFIDPARWGFDADGFAAAGIGAHACGSVLMKGSHMRLATMVHLARITDDGFELRSRYWIADRAEPRHDPVAGIAQLTTVPGFSGERQAYEQLVHDQTEFNHLATFLPDIYQEFGP 5xe5 B 2.17 BS01 MG B 1 E164 H269 E273 E154 H259 E263 VHPITYYPVDTQRLVRSNAERIRHKPYAHYFNPDVAVPEEVFAALKAPLEPEQVLGTSSTELNRLLEPGYLEGETGYCGLPDGAGYTSSLVRFPGATPEMFRWWFWWHSFEPERYSLWHPWCHADIWRTDPETETAPNLTDEQRYVGSTHHINEYIGQDPLDIEITFIDPARWGFDADGFAAAGIGAHACGSVLMKGSHMRLATMVHLARITDDGFELRSRYWIADRAEPRHDPVAGIAQLTTVPGFSGERQAYEQLVHDQTEFNHLATFLPDIYQEFGP 5xek A BS01 ZN A 1 C4 C7 C23 C26 C4 C7 C23 C26 EEECCICMDGRADLILPCAHSFCQKCIDKWSDRHRNCPICRL 5xek A BS02 ZN A 2 C18 H20 C37 C40 C18 H20 C37 C40 EEECCICMDGRADLILPCAHSFCQKCIDKWSDRHRNCPICRL 5xey B 1.82 BS01 83X B 1 F115 Y125 W128 I162 E164 I175 F177 M215 H217 Y232 Q266 H269 F105 Y115 W118 I146 E148 I159 F161 M199 H201 Y216 Q250 H253 VHPITYYPVDTQRLVRSNAERIRHKPYAHYFNPDVAVPEEVFAALKAPLEPEQVLGTSSTELNRLLEPGYLEGETGYCGLPDGAGYTSSLVRFPGATPEMFRWWFWWHSFEPERYSLWHPWCHADIWRTDPETEDEQRYVGSTHHINEYIGQDPLDIEITFIDPARWGFDADGFAAAGIGAHACGSVLMKGSHMRLATMVHLARITDDGFELRSRYWIADRAEPRHDPVAGIAQLTTVPGFSGERQAYEQLVHDQTEFNHLATFLPDIYQEFG 5xhp F 2.80 BS01 ARG F 1 D239 H260 E271 N272 G273 N338 S341 D200 H221 E232 N233 G234 N299 S302 SGHVSFAGIDYPLLPLNHQTPLVFQWFERNPDRFGQNEIPIINTQKNPYLNNIINAAIIEKERIIGIFVDGDFSKGQRKALGKLEQNYRNIKVIYNSDLNYSMYDKKLTTIYLENITKLEAQSASERDEVLLNGVKKSLEDVLKNNPEETLISSHNKDKGHLWFDFYRNLFLLKGSDAFLEAGKPGCHHLQPGGGCIYLDADMLLTDKLGTLYLPDGIAIHVSRKDNHVSLENGIIAVNRSEHPALIKGLEIMHSKPYGDPYNDWLSKGLRHYFDGSHIQDYDAFCDFIEFKHENIIMNTSSL 5xhp F 2.80 BS03 UDP F 1 Q64 W65 F66 Y88 F203 R207 Y237 D239 A240 D241 N338 S340 Q25 W26 F27 Y49 F164 R168 Y198 D200 A201 D202 N299 S301 SGHVSFAGIDYPLLPLNHQTPLVFQWFERNPDRFGQNEIPIINTQKNPYLNNIINAAIIEKERIIGIFVDGDFSKGQRKALGKLEQNYRNIKVIYNSDLNYSMYDKKLTTIYLENITKLEAQSASERDEVLLNGVKKSLEDVLKNNPEETLISSHNKDKGHLWFDFYRNLFLLKGSDAFLEAGKPGCHHLQPGGGCIYLDADMLLTDKLGTLYLPDGIAIHVSRKDNHVSLENGIIAVNRSEHPALIKGLEIMHSKPYGDPYNDWLSKGLRHYFDGSHIQDYDAFCDFIEFKHENIIMNTSSL 5xhp E 2.80 BS01 ARG E 1 H260 E271 N272 G273 N338 S341 H221 E232 N233 G234 N299 S302 SGHVSFAGIDYPLLPLNHQTPLVFQWFERNPDRFGQNEIPIINTQKNPYLNNIINAAIIEKERIIGIFVDGDFSKGQRKALGKLEQNYRNIKVIYNSDLNYSMYDKKLTTIYLENITKLEAQSASERDEVLLNGVKKSLEDVLKNNPEETLISSHNKDKGHLWFDFYRNLFLLKGSDAFLEAGKPGCHHLQPGGGCIYLDADMLLTDKLGTLYLPDGIAIHVSRKDNHVSLENGIIAVNRSEHPALIKGLEIMHSKPYGDPYNDWLSKGLRHYFDGSHIQDYDAFCDFIEFKHENIIMNTSSL 5xhp E 2.80 BS02 MN E 1 D239 D241 N338 S340 D200 D202 N299 S301 SGHVSFAGIDYPLLPLNHQTPLVFQWFERNPDRFGQNEIPIINTQKNPYLNNIINAAIIEKERIIGIFVDGDFSKGQRKALGKLEQNYRNIKVIYNSDLNYSMYDKKLTTIYLENITKLEAQSASERDEVLLNGVKKSLEDVLKNNPEETLISSHNKDKGHLWFDFYRNLFLLKGSDAFLEAGKPGCHHLQPGGGCIYLDADMLLTDKLGTLYLPDGIAIHVSRKDNHVSLENGIIAVNRSEHPALIKGLEIMHSKPYGDPYNDWLSKGLRHYFDGSHIQDYDAFCDFIEFKHENIIMNTSSL 5xhs A 2.19 BS01 SLL A 1 A86 Y102 R105 I142 H158 V221 W222 F223 Y255 A51 Y67 R70 I107 H123 V186 W187 F188 Y220 3.5.1.- PSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTFRFHFQGPCGTTLPEALA 5xhs A 2.19 BS02 MCM A 1 E225 N226 L227 L232 Y255 M259 E190 N191 L192 L197 Y220 M224 3.5.1.- PSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTFRFHFQGPCGTTLPEALA 5xht A BS01 ZN A 1 C3 C6 H25 C28 C3 C6 H25 C28 29430827 EMCDVCEVWTAESLFPCRVCTRVFHDGCLRRMGYIQGDSAAEVTEMAHTETGWSCHYCDN 5xht A BS02 ZN A 2 C17 C20 C55 C58 C17 C20 C55 C58 29430827 EMCDVCEVWTAESLFPCRVCTRVFHDGCLRRMGYIQGDSAAEVTEMAHTETGWSCHYCDN 5xhu A 2.10 BS01 FAD A 1 I13 G14 G16 P17 I18 I36 E37 F38 L39 G44 K45 F50 D57 Q88 R89 V90 A119 C120 G123 T124 L125 M257 G286 D287 L297 I298 I8 G9 G11 P12 I13 I31 E32 F33 L34 G39 K40 F45 D52 Q83 R84 V85 A114 C115 G118 T119 L120 M252 G281 D282 L292 I293 1.18.1.2 EVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGGKVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIVLTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVISGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNGDEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMRTNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV 5xhy A 1.98 BS01 8FC A 1 W81 P82 F83 L92 L94 Y97 Y139 N140 D145 I146 M149 W39 P40 F41 L50 L52 Y55 Y97 N98 D103 I104 M107 MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPT 5xjl 2 2.50 BS01 III M 1 P98 W102 Q105 Q106 Q109 V113 N116 P177 P178 L179 L180 S181 V183 G212 R213 Y216 V256 P257 A258 N260 P56 W60 Q63 Q64 Q67 V71 N74 P103 P104 L105 L106 S107 V109 G138 R139 Y142 V182 P183 A184 N186 21816274 EELMPRLLPVTPQEYLRRVQIEAAQCPDVVVAQIDPKQSVNISLSGCQPAPEGYSPTLQWQQQQVAQFSTVRQNVNKHRSHWMPKSEDEEGWKKFCLGEIGFPPLLSIVSRMNQATVTSVLEYLSNWFGERDFTPELGRWLYALLACLEKPLLPEAHSLIRQLARRCSEVRLLVDSKDDERVPALNLLICLVSRYFDQRDLADE 5xo7 A 1.88 BS01 36J A 1 G35 L36 A105 S106 P131 N134 I137 L138 M153 N156 S157 Y160 W185 Y189 P190 I193 P194 H243 G32 L33 A102 S103 P128 N131 I134 L135 M150 N153 S154 Y157 W182 Y186 P187 I190 P191 H240 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo7 B 1.88 BS01 36J B 1 G35 L36 A105 S106 P131 N134 M153 S157 W185 Y189 P190 I193 P194 H243 F244 G32 L33 A102 S103 P128 N131 M150 S154 W182 Y186 P187 I190 P191 H240 F241 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo7 C 1.88 BS01 36J C 1 G35 L36 A105 S106 P131 N134 N156 Y160 W185 Y189 P190 I193 P194 H243 G32 L33 A102 S103 P128 N131 N153 Y157 W182 Y186 P187 I190 P191 H240 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo7 D 1.88 BS01 36J D 1 D34 G35 L36 A105 S106 N134 L138 M153 S157 Y160 W185 Y189 P190 I193 P194 H243 D31 G32 L33 A102 S103 N131 L135 M150 S154 Y157 W182 Y186 P187 I190 P191 H240 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYL 5xo7 G 1.88 BS01 36J G 1 G35 L36 A105 S106 P131 N134 I137 M153 Y160 W185 Y189 P190 I193 P194 H243 G32 L33 A102 S103 P128 N131 I134 M150 Y157 W182 Y186 P187 I190 P191 H240 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo8 A 1.88 BS01 ZER A 1 G35 L36 A105 S106 P131 N134 L138 S157 Y160 W185 Y189 P190 I193 P194 H243 F244 G32 L33 A102 S103 P128 N131 L135 S154 Y157 W182 Y186 P187 I190 P191 H240 F241 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo8 B 1.88 BS01 ZER B 1 D34 G35 A105 S106 N134 I137 L138 M153 S157 Y160 W185 Y189 P190 I193 P194 H243 F244 D31 G32 A102 S103 N131 I134 L135 M150 S154 Y157 W182 Y186 P187 I190 P191 H240 F241 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo8 C 1.88 BS01 ZER C 1 G35 L36 A105 S106 P131 N134 I137 M153 S157 Y160 W185 Y189 P190 I193 P194 H243 F244 G32 L33 A102 S103 P128 N131 I134 M150 S154 Y157 W182 Y186 P187 I190 P191 H240 F241 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo8 D 1.88 BS01 ZER D 1 D34 G35 A105 S106 N134 M153 N156 S157 Y160 W185 Y189 P190 I193 P194 H243 F244 D32 G33 A103 S104 N132 M151 N154 S155 Y158 W183 Y187 P188 I191 P192 H241 F242 ATRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo8 E 1.88 BS01 ZER E 1 D34 G35 A105 S106 P131 N134 M153 S157 Y160 W185 Y189 P190 I193 P194 H243 F244 D31 G32 A102 S103 P128 N131 M150 S154 Y157 W182 Y186 P187 I190 P191 H240 F241 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo8 H 1.88 BS01 ZER H 1 D34 G35 A105 S106 P131 N134 L138 M153 N156 S157 Y160 W185 Y189 P190 I193 P194 H243 F244 D32 G33 A103 S104 P129 N132 L136 M151 N154 S155 Y158 W183 Y187 P188 I191 P192 H241 F242 ATRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYL 5xsv A 3.72 BS01 CO A 1 M780 E785 H787 M461 E466 H468 3.2.1.14 MAYRIVSETGDKITVELTLANKNTHYVWNGWCFDIKNITFETTGKVLSIKYADGGEPVYNVNGNLVTIDLTWRGIFHLNTTVKIIIEIQKSGDNPYPHNFKIHYLRGESIIYPTIGELPASWKPGNFTLSDLIADPKSYYDPHVKPHQNGFIMYNPPHPTQIIIGLADIDYPLNLASSARMWVPNKYFAMGLALAYEWFKVNPNFLMALAAKENWGTAVTKDPAFKGYKVIIDEEEYYWPVQIDHPDGIFQVESGNFNQIKAYYPDIFPDTADHDDYMKVSLDPNDTAWITSPIVAAVSLTMERELLYAAVGDKYNEFLRLAKDPWAETEIIDFGYNRGVGAIEALKIFSDNWEKAINAEVLWKEFNMEGFGGHVPTVINITATMDMETERIYDANLTWDDIEYFFTVVRQKFFRPGAISDEEWNAMMRDVKRAYDLLSQHWGGDHISYRYDFLTILRVAMKHWPEPHIPRPTGDDWYYHARNYNP 5xsv A 3.72 BS02 CO A 2 H396 D794 H77 D475 3.2.1.14 MAYRIVSETGDKITVELTLANKNTHYVWNGWCFDIKNITFETTGKVLSIKYADGGEPVYNVNGNLVTIDLTWRGIFHLNTTVKIIIEIQKSGDNPYPHNFKIHYLRGESIIYPTIGELPASWKPGNFTLSDLIADPKSYYDPHVKPHQNGFIMYNPPHPTQIIIGLADIDYPLNLASSARMWVPNKYFAMGLALAYEWFKVNPNFLMALAAKENWGTAVTKDPAFKGYKVIIDEEEYYWPVQIDHPDGIFQVESGNFNQIKAYYPDIFPDTADHDDYMKVSLDPNDTAWITSPIVAAVSLTMERELLYAAVGDKYNEFLRLAKDPWAETEIIDFGYNRGVGAIEALKIFSDNWEKAINAEVLWKEFNMEGFGGHVPTVINITATMDMETERIYDANLTWDDIEYFFTVVRQKFFRPGAISDEEWNAMMRDVKRAYDLLSQHWGGDHISYRYDFLTILRVAMKHWPEPHIPRPTGDDWYYHARNYNP 5xsv A 3.72 BS03 CO A 3 K666 S669 D670 K347 S350 D351 3.2.1.14 MAYRIVSETGDKITVELTLANKNTHYVWNGWCFDIKNITFETTGKVLSIKYADGGEPVYNVNGNLVTIDLTWRGIFHLNTTVKIIIEIQKSGDNPYPHNFKIHYLRGESIIYPTIGELPASWKPGNFTLSDLIADPKSYYDPHVKPHQNGFIMYNPPHPTQIIIGLADIDYPLNLASSARMWVPNKYFAMGLALAYEWFKVNPNFLMALAAKENWGTAVTKDPAFKGYKVIIDEEEYYWPVQIDHPDGIFQVESGNFNQIKAYYPDIFPDTADHDDYMKVSLDPNDTAWITSPIVAAVSLTMERELLYAAVGDKYNEFLRLAKDPWAETEIIDFGYNRGVGAIEALKIFSDNWEKAINAEVLWKEFNMEGFGGHVPTVINITATMDMETERIYDANLTWDDIEYFFTVVRQKFFRPGAISDEEWNAMMRDVKRAYDLLSQHWGGDHISYRYDFLTILRVAMKHWPEPHIPRPTGDDWYYHARNYNP 5xsv A 3.72 BS04 CO A 4 D764 H765 D445 H446 3.2.1.14 MAYRIVSETGDKITVELTLANKNTHYVWNGWCFDIKNITFETTGKVLSIKYADGGEPVYNVNGNLVTIDLTWRGIFHLNTTVKIIIEIQKSGDNPYPHNFKIHYLRGESIIYPTIGELPASWKPGNFTLSDLIADPKSYYDPHVKPHQNGFIMYNPPHPTQIIIGLADIDYPLNLASSARMWVPNKYFAMGLALAYEWFKVNPNFLMALAAKENWGTAVTKDPAFKGYKVIIDEEEYYWPVQIDHPDGIFQVESGNFNQIKAYYPDIFPDTADHDDYMKVSLDPNDTAWITSPIVAAVSLTMERELLYAAVGDKYNEFLRLAKDPWAETEIIDFGYNRGVGAIEALKIFSDNWEKAINAEVLWKEFNMEGFGGHVPTVINITATMDMETERIYDANLTWDDIEYFFTVVRQKFFRPGAISDEEWNAMMRDVKRAYDLLSQHWGGDHISYRYDFLTILRVAMKHWPEPHIPRPTGDDWYYHARNYNP 5xsx A 2.64 BS01 CTO A 1 E532 Q570 V571 E572 G574 N575 Y655 N656 R657 G658 V659 G660 A661 F690 E212 Q250 V251 E252 G254 N255 Y335 N336 R337 G338 V339 G340 A341 F370 3.2.1.14 AYRIVSETGDKITVELTLANKNTHYVWNGWCFDIKNITFETTGKVLSIKYADGGEPVYNVNGNLVTIDLTWRGIFHLNTTVKIIIEIQKSGDNPYPHNFKIHYLRGESIIYPTIGELPASWKPGNFTLSDLIADPKSYYDPHVKPHQNGFIMYNPPHPTQIIIGLADIDYPLNLASSARMWVPNKYFAMGLALAYEWFKVNPNFLMALAAKENWGTAVTKDPAFKGYKVIIDEEEYYWPVQIDHPDGIFQVESGNFNQIKAYYPDIFPDTADHDDYMKVSLDPNDTAWITSPIVAAVSLTMERELLYAAVGDKYNEFLRLAKDPWAETEIIDFGYNRGVGAIEALKIFSDNWEKAINAEVLWKEFNMEGFGGHVPTVINITATMDMETERIYDANLTWDDIEYFFTVVRQKFFRPGAISDEEWNAMMRDVKRAYDLLSQHWGGDHISYRYDFLTILRVAMKHWPEPHIPRPTGDDWYYHARNYNP 5xsx A 2.64 BS02 CBS A 1 N493 K531 E532 W534 Q561 Q570 N656 F690 G691 H693 N173 K211 E212 W214 Q241 Q250 N336 F370 G371 H373 3.2.1.14 AYRIVSETGDKITVELTLANKNTHYVWNGWCFDIKNITFETTGKVLSIKYADGGEPVYNVNGNLVTIDLTWRGIFHLNTTVKIIIEIQKSGDNPYPHNFKIHYLRGESIIYPTIGELPASWKPGNFTLSDLIADPKSYYDPHVKPHQNGFIMYNPPHPTQIIIGLADIDYPLNLASSARMWVPNKYFAMGLALAYEWFKVNPNFLMALAAKENWGTAVTKDPAFKGYKVIIDEEEYYWPVQIDHPDGIFQVESGNFNQIKAYYPDIFPDTADHDDYMKVSLDPNDTAWITSPIVAAVSLTMERELLYAAVGDKYNEFLRLAKDPWAETEIIDFGYNRGVGAIEALKIFSDNWEKAINAEVLWKEFNMEGFGGHVPTVINITATMDMETERIYDANLTWDDIEYFFTVVRQKFFRPGAISDEEWNAMMRDVKRAYDLLSQHWGGDHISYRYDFLTILRVAMKHWPEPHIPRPTGDDWYYHARNYNP 5xsx B 2.64 BS01 CTO B 1 E532 Q570 V571 E572 N575 Y655 N656 R657 G658 V659 G660 A661 E212 Q250 V251 E252 N255 Y335 N336 R337 G338 V339 G340 A341 3.2.1.14 AYRIVSETGDKITVELTLANKNTHYVWNGWCFDIKNITFETTGKVLSIKYADGGEPVYNVNGNLVTIDLTWRGIFHLNTTVKIIIEIQKSGDNPYPHNFKIHYLRGESIIYPTIGELPASWKPGNFTLSDLIADPKSYYDPHVKPHQNGFIMYNPPHPTQIIIGLADIDYPLNLASSARMWVPNKYFAMGLALAYEWFKVNPNFLMALAAKENWGTAVTKDPAFKGYKVIIDEEEYYWPVQIDHPDGIFQVESGNFNQIKAYYPDIFPDTADHDDYMKVSLDPNDTAWITSPIVAAVSLTMERELLYAAVGDKYNEFLRLAKDPWAETEIIDFGYNRGVGAIEALKIFSDNWEKAINAEVLWKEFNMEGFGGHVPTVINITATMDMETERIYDANLTWDDIEYFFTVVRQKFFRPGAISDEEWNAMMRDVKRAYDLLSQHWGGDHISYRYDFLTILRVAMKHWPEPHIPRPTGDDWYYHARNYNP 5xsx B 2.64 BS02 CBS B 1 N493 L494 K531 E532 N533 W534 Q561 H564 Q570 N656 F690 N173 L174 K211 E212 N213 W214 Q241 H244 Q250 N336 F370 3.2.1.14 AYRIVSETGDKITVELTLANKNTHYVWNGWCFDIKNITFETTGKVLSIKYADGGEPVYNVNGNLVTIDLTWRGIFHLNTTVKIIIEIQKSGDNPYPHNFKIHYLRGESIIYPTIGELPASWKPGNFTLSDLIADPKSYYDPHVKPHQNGFIMYNPPHPTQIIIGLADIDYPLNLASSARMWVPNKYFAMGLALAYEWFKVNPNFLMALAAKENWGTAVTKDPAFKGYKVIIDEEEYYWPVQIDHPDGIFQVESGNFNQIKAYYPDIFPDTADHDDYMKVSLDPNDTAWITSPIVAAVSLTMERELLYAAVGDKYNEFLRLAKDPWAETEIIDFGYNRGVGAIEALKIFSDNWEKAINAEVLWKEFNMEGFGGHVPTVINITATMDMETERIYDANLTWDDIEYFFTVVRQKFFRPGAISDEEWNAMMRDVKRAYDLLSQHWGGDHISYRYDFLTILRVAMKHWPEPHIPRPTGDDWYYHARNYNP 5xzu A 1.70 BS01 CBI A 1 A48 N49 K52 H85 W89 E92 N135 E136 E217 H219 E249 W289 W297 A47 N48 K51 H84 W88 E91 N134 E135 E216 H218 E248 W288 W296 3.2.1.8 WGLNNAARADGKLWFGTAADIPGLEQDDRYYMKEYNNTHDFGGTTPANIMKFMFTEPEQNVFNFTGAQEFLDIAFASHKLVRCHNLIWQSELPTWVTNPTTNWTNETLSKVLQNHVYTLVSHFGDQCYSWDVVNEALSDDPAGSYQNNIWFDTIGPEYVAMAFEYAEKAVKDHKLNVKLYYNDYNIEYPGPKSTAAQNIVKELKARNIQIDGVGLESHFIAGETPSQATQITNMADFTSLDIDVAVTELDVRLYLPPNATSEAQQVADYYATVAACAATERCIGITVWDFDDTYSWVPSTFAGQGYADLFFQPDGPNTPLVKKAAYDGCLQALQ 5y05 A 2.80 BS01 ZN A 1 C204 C207 C230 C233 C198 C201 C224 C227 29497021 MKAEVSQQRSLLTLSEVDAELARIAHRGKNLAEQKRLDELTAQRGEVNDRLAALGIALEDLDAQVAKYESEIDSVRQREDRDRALGAKQVTEIQHELETLQRRQASLEEQLLEVMERREELMAERSEELRRVDELQTELTEAQQARDAALVELDQARHQCATRRDALVNAIDDQLVELYEKQRARGGAGAGPLQGRRCGACRIEIDRGEIARITAAADDDVVRCPECGAILLR 5y2z A 2.67 BS02 CA A 2 E446 N449 F451 E453 E456 D459 E214 N217 F219 E221 E224 D227 29670100 NVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHN 5y2z C 2.67 BS02 CA C 2 E446 C447 N449 F451 E453 E456 D459 E214 C215 N217 F219 E221 E224 D227 29670100 NVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHN 5y2z G 2.67 BS02 CA G 2 E446 C447 N449 F451 E453 E456 D459 E214 C215 N217 F219 E221 E224 D227 29670100 NVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCCNKRDVLCGYLLCTNIGNIPRLGELDGCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHN 5y2z B 2.67 BS01 CA B 1 D334 E336 D381 V382 D111 E113 D158 V159 29670100 TEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHV 5y2z F 2.67 BS02 FUC F 1 Q423 T424 Q200 T201 29670100 TEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHV 5y2z J 2.67 BS02 FUC J 1 N422 T424 N199 T201 29670100 TEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHV 5y86 A 1.90 BS01 HRM A 1 F220 V223 A236 K238 I272 F288 E289 L290 L291 L342 I354 D355 F83 V86 A99 K101 I135 F151 E152 L153 L154 L205 I217 D218 2.7.12.1 29634919 VVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 5yj8 A 1.76 BS01 8W9 A 1 Y566 Y573 F591 Y594 N596 Y18 Y25 F43 Y46 N48 HHHHHMMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFIDYGNYEEVLLSNIKPI 5ymt C 2.20 BS02 GAL C 2 H106 G107 W111 H106 G107 W111 VLDGPYQPVAFKPPNDYWILVNSNSNGVVLEGTNNTDVWVAIISIEPNVNSESRQYSLFGVNKQITVVNTSNKWKFMEMFRNNSNAEFQHKRTLTSSTKLVGILKHGGRLWTYHGETPNATTDYSTTSNLNEISVTTYAEFYIIPRSQESKCTEYINTGL 5yq7 E 4.10 BS01 BCL E 1 G36 L37 H44 W53 G26 L27 H34 W43 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 E 4.10 BS02 BCL E 2 W14 H26 V29 V30 I33 Y34 W4 H16 V19 V20 I23 Y24 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 E 4.10 BS03 BCL D 1 A40 H44 A30 H34 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 E 4.10 BS04 KGD A 1 I28 V29 I33 I18 V19 I23 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 B 4.10 BS01 BCL B 1 G36 L37 H44 C47 W53 G26 L27 H34 C37 W43 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 B 4.10 BS03 BCL A 1 A40 A43 H44 A30 A33 H34 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 B 4.10 BS04 KGD 9 1 V29 I33 V19 I23 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 0 4.10 BS01 BCL B 3 L24 I39 L14 I29 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 0 4.10 BS02 BCL 0 1 I33 G36 L37 A40 H44 C47 W53 I23 G26 L27 A30 H34 C37 W43 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 0 4.10 BS03 BCL 0 2 P11 W14 H26 V29 V30 I33 P1 W4 H16 V19 V20 I23 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 0 4.10 BS05 BCL 9 1 A40 H44 C47 A30 H34 C37 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 L 4.10 BS01 III Y 1 L173 W269 L276 F283 L172 W268 L275 F282 29674684 SAVPRALPLPSGETLPAEAISSTGSQAASAEVIPFSIIEEFYKRPGKTLAARFFGVDPFDFWIGRFYVGLFGAISIIGIILGVAFYLYEGVVNEGTLNILAMRIEPPPVSQGLNVDPAQPGFFWFLTMVAATIAFVGWLLRQIDISLKLDMGMEVPIAFGAVVSSWITLQWLRPIAMGAWGHGFPLGITHHLDWVSNIGYQYYNFFYNPFHAIGITLLFASTLFLHMHGSAVLSEAKRNISDQNIHVFWRNILGYSIGEIGIHRVAFWTGAASVLFSNLCIFLSGTFVKDWNAFWGFWDKMPIWNGVGQ 5yq7 L 4.10 BS02 BCL L 1 W167 F185 H192 L193 W166 F184 H191 L192 29674684 SAVPRALPLPSGETLPAEAISSTGSQAASAEVIPFSIIEEFYKRPGKTLAARFFGVDPFDFWIGRFYVGLFGAISIIGIILGVAFYLYEGVVNEGTLNILAMRIEPPPVSQGLNVDPAQPGFFWFLTMVAATIAFVGWLLRQIDISLKLDMGMEVPIAFGAVVSSWITLQWLRPIAMGAWGHGFPLGITHHLDWVSNIGYQYYNFFYNPFHAIGITLLFASTLFLHMHGSAVLSEAKRNISDQNIHVFWRNILGYSIGEIGIHRVAFWTGAASVLFSNLCIFLSGTFVKDWNAFWGFWDKMPIWNGVGQ 5yq7 L 4.10 BS03 BCL L 2 F136 V163 I199 G200 F206 F207 H212 I216 V275 S278 N279 I282 F135 V162 I198 G199 F205 F206 H211 I215 V274 S277 N278 I281 29674684 SAVPRALPLPSGETLPAEAISSTGSQAASAEVIPFSIIEEFYKRPGKTLAARFFGVDPFDFWIGRFYVGLFGAISIIGIILGVAFYLYEGVVNEGTLNILAMRIEPPPVSQGLNVDPAQPGFFWFLTMVAATIAFVGWLLRQIDISLKLDMGMEVPIAFGAVVSSWITLQWLRPIAMGAWGHGFPLGITHHLDWVSNIGYQYYNFFYNPFHAIGITLLFASTLFLHMHGSAVLSEAKRNISDQNIHVFWRNILGYSIGEIGIHRVAFWTGAASVLFSNLCIFLSGTFVKDWNAFWGFWDKMPIWNGVGQ 5yq7 L 4.10 BS04 BPH L 1 I80 V84 W139 Q143 A159 F160 L187 G188 I189 G271 V275 I79 V83 W138 Q142 A158 F159 L186 G187 I188 G270 V274 29674684 SAVPRALPLPSGETLPAEAISSTGSQAASAEVIPFSIIEEFYKRPGKTLAARFFGVDPFDFWIGRFYVGLFGAISIIGIILGVAFYLYEGVVNEGTLNILAMRIEPPPVSQGLNVDPAQPGFFWFLTMVAATIAFVGWLLRQIDISLKLDMGMEVPIAFGAVVSSWITLQWLRPIAMGAWGHGFPLGITHHLDWVSNIGYQYYNFFYNPFHAIGITLLFASTLFLHMHGSAVLSEAKRNISDQNIHVFWRNILGYSIGEIGIHRVAFWTGAASVLFSNLCIFLSGTFVKDWNAFWGFWDKMPIWNGVGQ 5yq7 L 4.10 BS05 MQE L 1 F225 H247 W250 S257 I258 G259 E260 I261 I263 V266 W269 F224 H246 W249 S256 I257 G258 E259 I260 I262 V265 W268 29674684 SAVPRALPLPSGETLPAEAISSTGSQAASAEVIPFSIIEEFYKRPGKTLAARFFGVDPFDFWIGRFYVGLFGAISIIGIILGVAFYLYEGVVNEGTLNILAMRIEPPPVSQGLNVDPAQPGFFWFLTMVAATIAFVGWLLRQIDISLKLDMGMEVPIAFGAVVSSWITLQWLRPIAMGAWGHGFPLGITHHLDWVSNIGYQYYNFFYNPFHAIGITLLFASTLFLHMHGSAVLSEAKRNISDQNIHVFWRNILGYSIGEIGIHRVAFWTGAASVLFSNLCIFLSGTFVKDWNAFWGFWDKMPIWNGVGQ 5yq7 L 4.10 BS06 FE L 1 H229 H264 H228 H263 29674684 SAVPRALPLPSGETLPAEAISSTGSQAASAEVIPFSIIEEFYKRPGKTLAARFFGVDPFDFWIGRFYVGLFGAISIIGIILGVAFYLYEGVVNEGTLNILAMRIEPPPVSQGLNVDPAQPGFFWFLTMVAATIAFVGWLLRQIDISLKLDMGMEVPIAFGAVVSSWITLQWLRPIAMGAWGHGFPLGITHHLDWVSNIGYQYYNFFYNPFHAIGITLLFASTLFLHMHGSAVLSEAKRNISDQNIHVFWRNILGYSIGEIGIHRVAFWTGAASVLFSNLCIFLSGTFVKDWNAFWGFWDKMPIWNGVGQ 5yq7 L 4.10 BS07 BCL R 1 A74 I78 A73 I77 29674684 SAVPRALPLPSGETLPAEAISSTGSQAASAEVIPFSIIEEFYKRPGKTLAARFFGVDPFDFWIGRFYVGLFGAISIIGIILGVAFYLYEGVVNEGTLNILAMRIEPPPVSQGLNVDPAQPGFFWFLTMVAATIAFVGWLLRQIDISLKLDMGMEVPIAFGAVVSSWITLQWLRPIAMGAWGHGFPLGITHHLDWVSNIGYQYYNFFYNPFHAIGITLLFASTLFLHMHGSAVLSEAKRNISDQNIHVFWRNILGYSIGEIGIHRVAFWTGAASVLFSNLCIFLSGTFVKDWNAFWGFWDKMPIWNGVGQ 5yq7 L 4.10 BS08 MQE M 1 F67 I77 I81 V84 L88 R142 F66 I76 I80 V83 L87 R141 29674684 SAVPRALPLPSGETLPAEAISSTGSQAASAEVIPFSIIEEFYKRPGKTLAARFFGVDPFDFWIGRFYVGLFGAISIIGIILGVAFYLYEGVVNEGTLNILAMRIEPPPVSQGLNVDPAQPGFFWFLTMVAATIAFVGWLLRQIDISLKLDMGMEVPIAFGAVVSSWITLQWLRPIAMGAWGHGFPLGITHHLDWVSNIGYQYYNFFYNPFHAIGITLLFASTLFLHMHGSAVLSEAKRNISDQNIHVFWRNILGYSIGEIGIHRVAFWTGAASVLFSNLCIFLSGTFVKDWNAFWGFWDKMPIWNGVGQ 5yq7 L 4.10 BS09 BPH M 1 A213 I216 T217 A212 I215 T216 29674684 SAVPRALPLPSGETLPAEAISSTGSQAASAEVIPFSIIEEFYKRPGKTLAARFFGVDPFDFWIGRFYVGLFGAISIIGIILGVAFYLYEGVVNEGTLNILAMRIEPPPVSQGLNVDPAQPGFFWFLTMVAATIAFVGWLLRQIDISLKLDMGMEVPIAFGAVVSSWITLQWLRPIAMGAWGHGFPLGITHHLDWVSNIGYQYYNFFYNPFHAIGITLLFASTLFLHMHGSAVLSEAKRNISDQNIHVFWRNILGYSIGEIGIHRVAFWTGAASVLFSNLCIFLSGTFVKDWNAFWGFWDKMPIWNGVGQ 5yq7 L 4.10 BS10 BPH M 2 F220 T223 L224 H227 M228 L254 F219 T222 L223 H226 M227 L253 29674684 SAVPRALPLPSGETLPAEAISSTGSQAASAEVIPFSIIEEFYKRPGKTLAARFFGVDPFDFWIGRFYVGLFGAISIIGIILGVAFYLYEGVVNEGTLNILAMRIEPPPVSQGLNVDPAQPGFFWFLTMVAATIAFVGWLLRQIDISLKLDMGMEVPIAFGAVVSSWITLQWLRPIAMGAWGHGFPLGITHHLDWVSNIGYQYYNFFYNPFHAIGITLLFASTLFLHMHGSAVLSEAKRNISDQNIHVFWRNILGYSIGEIGIHRVAFWTGAASVLFSNLCIFLSGTFVKDWNAFWGFWDKMPIWNGVGQ 5yq7 8 4.10 BS04 KGD 5 1 V25 V29 V15 V19 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 6 4.10 BS01 BCL 8 3 I39 A43 I29 A33 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 6 4.10 BS02 BCL 6 1 L37 H44 W53 L27 H34 W43 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 6 4.10 BS03 BCL 6 2 W14 H26 V29 V30 I33 W4 H16 V19 V20 I23 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 6 4.10 BS04 BCL 5 1 I39 A40 H44 I29 A30 H34 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 4 4.10 BS01 BCL 4 1 G36 H44 C47 W53 G26 H34 C37 W43 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 2 4.10 BS01 BCL 2 1 G36 H44 W53 G26 H34 W43 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 2 4.10 BS02 BCL 2 2 W14 H26 V29 V30 I33 Y34 L37 W4 H16 V19 V20 I23 Y24 L27 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 2 4.10 BS03 BCL 1 1 I39 C47 I29 C37 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 K 4.10 BS01 BCL K 1 L37 H44 C47 W53 L27 H34 C37 W43 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 C 4.10 BS01 HEM C 1 Q83 V91 V93 L94 M106 V107 V110 C118 C121 H122 A128 R143 Q67 V75 V77 L78 M90 V91 V94 C102 C105 H106 A112 R127 29674684 RGRFYIVAGIISVVMAVASIAIFWWIFYTITPAPAPPLQNPIYVNYTQEPTDYISAESLAAMNAYIQANPQPQAVQVLKGMTTAQISAYMVAQVSGGLKVDCSYCHNIANFAQQDGYPNAAKKVTARKMMLMSADLNQNYTAKLPASVGGYQITCATCHNGKAAGLEPYPIEIMNTLPNDWRLPLELDYPGGLVVTGRKDVSNHEVEQNQFAMYHMNVSMGQGCTFCHNARYFPSYEIAQKNHSIIMLQMTKHIQETYVAPGGRIADGIMAGKSPSCWLCHQGANIPPGAAKP 5yq7 C 4.10 BS02 HEM C 2 Y120 M145 M146 M148 C171 C174 H175 G181 L182 I285 M286 Y104 M129 M130 M132 C155 C158 H159 G165 L166 I269 M270 29674684 RGRFYIVAGIISVVMAVASIAIFWWIFYTITPAPAPPLQNPIYVNYTQEPTDYISAESLAAMNAYIQANPQPQAVQVLKGMTTAQISAYMVAQVSGGLKVDCSYCHNIANFAQQDGYPNAAKKVTARKMMLMSADLNQNYTAKLPASVGGYQITCATCHNGKAAGLEPYPIEIMNTLPNDWRLPLELDYPGGLVVTGRKDVSNHEVEQNQFAMYHMNVSMGQGCTFCHNARYFPSYEIAQKNHSIIMLQMTKHIQETYVAPGGRIADGIMAGKSPSCWLCHQGANIPPGAAKP 5yq7 C 4.10 BS03 HEM C 3 Y205 G207 G208 L209 V210 V211 T212 M229 C240 C243 H244 P250 I261 Y189 G191 G192 L193 V194 V195 T196 M213 C224 C227 H228 P234 I245 29674684 RGRFYIVAGIISVVMAVASIAIFWWIFYTITPAPAPPLQNPIYVNYTQEPTDYISAESLAAMNAYIQANPQPQAVQVLKGMTTAQISAYMVAQVSGGLKVDCSYCHNIANFAQQDGYPNAAKKVTARKMMLMSADLNQNYTAKLPASVGGYQITCATCHNGKAAGLEPYPIEIMNTLPNDWRLPLELDYPGGLVVTGRKDVSNHEVEQNQFAMYHMNVSMGQGCTFCHNARYFPSYEIAQKNHSIIMLQMTKHIQETYVAPGGRIADGIMAGKSPSCWLCHQGANIPPGAAKP 5yq7 C 4.10 BS04 HEM C 4 G165 G166 Y167 I169 C174 M232 Q256 H259 M263 C293 H297 N301 I302 G149 G150 Y151 I153 C158 M216 Q240 H243 M247 C277 H281 N285 I286 29674684 RGRFYIVAGIISVVMAVASIAIFWWIFYTITPAPAPPLQNPIYVNYTQEPTDYISAESLAAMNAYIQANPQPQAVQVLKGMTTAQISAYMVAQVSGGLKVDCSYCHNIANFAQQDGYPNAAKKVTARKMMLMSADLNQNYTAKLPASVGGYQITCATCHNGKAAGLEPYPIEIMNTLPNDWRLPLELDYPGGLVVTGRKDVSNHEVEQNQFAMYHMNVSMGQGCTFCHNARYFPSYEIAQKNHSIIMLQMTKHIQETYVAPGGRIADGIMAGKSPSCWLCHQGANIPPGAAKP 5yq7 I 4.10 BS02 BCL I 2 P11 W14 H26 V29 V30 I33 L37 P1 W4 H16 V19 V20 I23 L27 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 I 4.10 BS03 BCL H 1 I39 H44 I29 H34 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 G 4.10 BS01 BCL G 1 I33 G36 L37 H44 C47 W53 I23 G26 L27 H34 C37 W43 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 W 4.10 BS03 KGD T 1 V25 V29 I33 V15 V19 I23 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 U 4.10 BS02 BCL U 1 T32 G36 L37 A40 H44 W53 T22 G26 L27 A30 H34 W43 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 T 4.10 BS01 BCL U 1 A23 I26 H27 F36 A19 I22 H23 F32 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 T 4.10 BS02 BCL U 3 F8 S11 F4 S7 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 T 4.10 BS03 KGD T 3 T16 G19 M22 T12 G15 M18 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 T 4.10 BS04 BCL T 1 V13 T16 H27 W38 V9 T12 H23 W34 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 S 4.10 BS03 BCL R 1 G36 A40 H44 G26 A30 H34 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 Q 4.10 BS02 BCL Q 2 W14 H26 V29 V30 I33 L37 W4 H16 V19 V20 I23 L27 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 Q 4.10 BS03 BCL P 1 H44 C47 H34 C37 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 Q 4.10 BS04 KGD N 1 I28 V29 I18 V19 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 O 4.10 BS02 BCL O 2 P11 W14 H26 V30 I33 P1 W4 H16 V20 I23 29674684 PDQWKPLFNNAQWLVHDIVVKTIYGGLIIAVIAHVLCWAWTPWI 5yq7 V 4.10 BS01 BCL W 1 A23 I26 H27 V30 A19 I22 H23 V26 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 V 4.10 BS02 KGD T 1 G19 M22 I26 G15 M18 I22 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 V 4.10 BS03 BCL V 1 H27 W38 H23 W34 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 R 4.10 BS01 KGD T 4 L24 H27 L20 H23 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 R 4.10 BS02 BCL S 1 I26 H27 I22 H23 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 R 4.10 BS03 KGD R 1 L18 G19 M22 L14 G15 M18 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 R 4.10 BS04 BCL R 1 T16 L20 H27 W38 T12 L16 H23 W34 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 P 4.10 BS01 BCL Q 1 A23 I26 H27 A19 I22 H23 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 P 4.10 BS04 BCL P 1 T16 L20 A23 H27 W38 T12 L16 A19 H23 W34 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 P 4.10 BS06 MQE M 1 V21 L24 L25 V17 L20 L21 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 N 4.10 BS02 KGD N 2 S15 T16 L18 G19 M22 I26 S11 T12 L14 G15 M18 I22 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 N 4.10 BS03 BCL N 1 V13 L20 A23 H27 W38 V9 L16 A19 H23 W34 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 J 4.10 BS01 BCL K 1 I26 H27 F36 I22 H23 F32 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 J 4.10 BS03 KGD N 3 H27 F28 L31 H23 F24 L27 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 J 4.10 BS04 KGD J 1 S15 T16 L18 G19 M22 S11 T12 L14 G15 M18 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 H 4.10 BS01 BCL I 1 H27 V30 H23 V26 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 H 4.10 BS03 BCL H 1 V13 T16 L20 A23 H27 F36 W38 V9 T12 L16 A19 H23 F32 W34 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 H 4.10 BS05 BCL F 1 T10 V14 S15 T6 V10 S11 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 F 4.10 BS03 KGD F 1 T16 L18 G19 M22 T12 L14 G15 M18 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 F 4.10 BS04 BCL F 1 G19 L20 H27 L31 W38 G15 L16 H23 L27 W34 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 F 4.10 BS05 BCL D 1 V14 I26 V10 I22 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 D 4.10 BS03 BCL D 1 T16 L20 H27 L31 W38 T12 L16 H23 L27 W34 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 D 4.10 BS04 KGD A 1 L18 G19 M22 I26 L14 G15 M18 I22 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 A 4.10 BS01 BCL B 1 A23 H27 F36 A19 H23 F32 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 A 4.10 BS03 BCL A 1 V13 T16 L20 A23 H27 L31 F36 W38 V9 T12 L16 A19 H23 L27 F32 W34 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 A 4.10 BS04 KGD 9 1 T16 L18 G19 M22 I26 T12 L14 G15 M18 I22 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 A 4.10 BS05 BCL 9 1 F6 V14 F2 V10 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 9 4.10 BS05 BCL 9 1 V13 H27 W38 V9 H23 W34 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 7 4.10 BS02 KGD 9 4 L24 H27 F28 L20 H23 F24 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 7 4.10 BS04 KGD 5 1 V12 S15 T16 L18 G19 M22 L25 I26 V8 S11 T12 L14 G15 M18 L21 I22 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 5 4.10 BS01 BCL 6 1 A23 H27 A19 H23 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 5 4.10 BS02 KGD 5 1 H27 F28 H23 F24 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 5 4.10 BS03 BCL 5 1 V13 T16 L20 H27 W38 V9 T12 L16 H23 W34 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 3 4.10 BS05 BCL 1 1 S11 S15 S7 S11 29674684 PFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR 5yq7 M 4.10 BS01 BCL L 1 M526 I529 F530 L533 G534 L537 M191 I194 F195 L198 G199 L202 29674684 IDLHDEEYRDGLEGTIAKPPGHVGWMQRLLGEGQVGPIYVGLWGVISFITFFASAFIILVDYGRQVGWNPIIYLREFWNLAVYPPPTEYGLSWNVPWDKGGAWLAATFFLHISVLTWWARLYTRAKATGVGTQLAWGFASALSLYFVIYLFHPLALGNWSAAPGHGFRAILDWTNYVSIHWGNFYYNPFHMLSIFFLLGSTLLLAMHGATIVATSKWKSEMEFTEMMAEGPGTQRAQLFWRWVMGWNANSYNIHIWAWWFAAFTAITGAIGLFLSGTLVPDWYAWGETAKIVAPWPNPDWAQYVF 5yq7 M 4.10 BS02 BPH L 1 L533 T536 L537 M541 W575 L198 T201 L202 M206 W240 29674684 IDLHDEEYRDGLEGTIAKPPGHVGWMQRLLGEGQVGPIYVGLWGVISFITFFASAFIILVDYGRQVGWNPIIYLREFWNLAVYPPPTEYGLSWNVPWDKGGAWLAATFFLHISVLTWWARLYTRAKATGVGTQLAWGFASALSLYFVIYLFHPLALGNWSAAPGHGFRAILDWTNYVSIHWGNFYYNPFHMLSIFFLLGSTLLLAMHGATIVATSKWKSEMEFTEMMAEGPGTQRAQLFWRWVMGWNANSYNIHIWAWWFAAFTAITGAIGLFLSGTLVPDWYAWGETAKIVAPWPNPDWAQYVF 5yq7 M 4.10 BS03 FE L 1 H542 E557 H589 H207 E222 H254 29674684 IDLHDEEYRDGLEGTIAKPPGHVGWMQRLLGEGQVGPIYVGLWGVISFITFFASAFIILVDYGRQVGWNPIIYLREFWNLAVYPPPTEYGLSWNVPWDKGGAWLAATFFLHISVLTWWARLYTRAKATGVGTQLAWGFASALSLYFVIYLFHPLALGNWSAAPGHGFRAILDWTNYVSIHWGNFYYNPFHMLSIFFLLGSTLLLAMHGATIVATSKWKSEMEFTEMMAEGPGTQRAQLFWRWVMGWNANSYNIHIWAWWFAAFTAITGAIGLFLSGTLVPDWYAWGETAKIVAPWPNPDWAQYVF 5yq7 M 4.10 BS04 MQE M 1 M541 H542 T545 W575 W581 A583 N584 I588 M206 H207 T210 W240 W246 A248 N249 I253 29674684 IDLHDEEYRDGLEGTIAKPPGHVGWMQRLLGEGQVGPIYVGLWGVISFITFFASAFIILVDYGRQVGWNPIIYLREFWNLAVYPPPTEYGLSWNVPWDKGGAWLAATFFLHISVLTWWARLYTRAKATGVGTQLAWGFASALSLYFVIYLFHPLALGNWSAAPGHGFRAILDWTNYVSIHWGNFYYNPFHMLSIFFLLGSTLLLAMHGATIVATSKWKSEMEFTEMMAEGPGTQRAQLFWRWVMGWNANSYNIHIWAWWFAAFTAITGAIGLFLSGTLVPDWYAWGETAKIVAPWPNPDWAQYVF 5yq7 M 4.10 BS05 BCL M 1 F386 L479 S513 F519 Y520 H525 S528 I529 L532 G603 L607 F51 L144 S178 F184 Y185 H190 S193 I194 L197 G268 L272 29674684 IDLHDEEYRDGLEGTIAKPPGHVGWMQRLLGEGQVGPIYVGLWGVISFITFFASAFIILVDYGRQVGWNPIIYLREFWNLAVYPPPTEYGLSWNVPWDKGGAWLAATFFLHISVLTWWARLYTRAKATGVGTQLAWGFASALSLYFVIYLFHPLALGNWSAAPGHGFRAILDWTNYVSIHWGNFYYNPFHMLSIFFLLGSTLLLAMHGATIVATSKWKSEMEFTEMMAEGPGTQRAQLFWRWVMGWNANSYNIHIWAWWFAAFTAITGAIGLFLSGTLVPDWYAWGETAKIVAPWPNPDWAQYVF 5yq7 M 4.10 BS06 BPH M 1 L445 I483 Y484 F502 R503 I505 L506 L110 I148 Y149 F167 R168 I170 L171 29674684 IDLHDEEYRDGLEGTIAKPPGHVGWMQRLLGEGQVGPIYVGLWGVISFITFFASAFIILVDYGRQVGWNPIIYLREFWNLAVYPPPTEYGLSWNVPWDKGGAWLAATFFLHISVLTWWARLYTRAKATGVGTQLAWGFASALSLYFVIYLFHPLALGNWSAAPGHGFRAILDWTNYVSIHWGNFYYNPFHMLSIFFLLGSTLLLAMHGATIVATSKWKSEMEFTEMMAEGPGTQRAQLFWRWVMGWNANSYNIHIWAWWFAAFTAITGAIGLFLSGTLVPDWYAWGETAKIVAPWPNPDWAQYVF 5yq7 M 4.10 BS07 BPH M 3 F386 W452 F473 A476 F51 W117 F138 A141 29674684 IDLHDEEYRDGLEGTIAKPPGHVGWMQRLLGEGQVGPIYVGLWGVISFITFFASAFIILVDYGRQVGWNPIIYLREFWNLAVYPPPTEYGLSWNVPWDKGGAWLAATFFLHISVLTWWARLYTRAKATGVGTQLAWGFASALSLYFVIYLFHPLALGNWSAAPGHGFRAILDWTNYVSIHWGNFYYNPFHMLSIFFLLGSTLLLAMHGATIVATSKWKSEMEFTEMMAEGPGTQRAQLFWRWVMGWNANSYNIHIWAWWFAAFTAITGAIGLFLSGTLVPDWYAWGETAKIVAPWPNPDWAQYVF 5ysb A 2.20 BS01 ZN A 1 H75 E100 H418 H41 E66 H384 29678880 KVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHH 5ysb A 2.20 BS02 ZN A 2 E51 D335 E17 D301 29678880 KVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHH 5ysb A 2.20 BS03 ZN A 3 N271 D275 N237 D241 29678880 KVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHH 5ysb A 2.20 BS04 ZN A 4 E388 R392 E354 R358 29678880 KVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHH 5ysb A 2.20 BS05 ZN A 5 E103 H419 E69 H385 29678880 KVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHH 5ysd A 2.10 BS01 MG A 1 S181 G184 M187 S148 G151 M154 29678880 SKVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHH 5ysd A 2.10 BS02 BGC A 1 W71 G94 T95 T96 W97 E147 Q197 G300 G301 W38 G61 T62 T63 W64 E114 Q164 G267 G268 29678880 SKVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHH 5ysd A 2.10 BS03 BGC A 2 G43 E45 W71 Y145 W268 G10 E12 W38 Y112 W235 29678880 SKVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHH 5ysd A 2.10 BS04 GLC A 1 W71 D193 N195 E196 Q197 W38 D160 N162 E163 Q164 29678880 SKVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHH 5yse A 1.60 BS01 MG A 1 S181 G184 K185 M187 S147 G150 K151 M153 29678880 KVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHHH 5yse A 1.60 BS03 BGC A 2 E45 W71 Y145 W268 E11 W37 Y111 W234 29678880 KVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHHH 5yse A 1.60 BS04 BGC A 3 W71 D193 E196 Q197 W37 D159 E162 Q163 29678880 KVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHHH 5yse A 1.60 BS05 GLC A 1 W71 W268 W37 W234 29678880 KVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHHH 5ysf A 1.90 BS02 BGC A 1 D193 F263 M264 S265 W268 D160 F230 M231 S232 W235 29678880 SKVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHHH 5ysf A 1.90 BS03 BGC A 2 D193 N195 E196 Q197 D160 N162 E163 Q164 29678880 SKVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHHH 5ysf B 1.90 BS01 BGC B 1 F263 M264 S265 W268 F230 M231 S232 W235 29678880 SKVLNVWAMGDEAKSLKELAQKFTKDTGIEVKVQVIPWANAHDKLLTAVASKSGPDVVQMGTTWMPEFVEAGALLDITKDVEKSKNMNSDLFFPGSVKTTQFDGKTYGVPWYAETRVLFYRTDLLKKVGYNEAPKTWDELSDAALKLSKRGKDMYGFAIDPNEQTTGFIFGRQNGSPLFDKDGTPVFNKKPFVDTVTYLDSFIKNGSAPDTDLGLDASQSFGGDGIVPMFMSGPWMVNTLKDTAPDIDGKWATAVLPKKENNESSLGGANLSIFKYSNKKDDALKFMDYMSQPDVQLSWLKDTNSMPARMDAWEDDMLKNDPYYKVFGEQMKTAEPMPLIPQFEEIAQLYGKSWEQIYRGGADVQTQMDTFNDQVEALLKKLEHHHHHH 5yu0 A 1.92 BS01 NAD A 1 Y81 T93 I94 T118 R121 T122 I144 G145 G147 A148 Q149 D170 T171 H175 A208 T209 S210 V211 V218 V233 G234 A235 D236 K240 S301 T302 G303 Y81 T93 I94 T118 R121 T122 I144 G145 G147 A148 Q149 D170 T171 H175 A208 T209 S210 V211 V218 V233 G234 A235 D236 K240 S301 T302 G303 4.3.1.12 29629557 METWVLGRRDVAEVVAAVGRDELMRRIIDRLTGGLAEIGRGERHLSPLRGGLERSEPVPGIWEWMPHREPGDHITLKTVGYSPANPARFGLPTILGTVARYDDTTGALTALMDGVLLTALRTGAASAVASRLLARPDSHTLGLIGTGAQAVTQLHALSLVLPLQRALVWDTDPAHRESFARRAAFTGVSVEIAEPARIAAEADVISTATSVAVGQGPVLPDTGVREHLHINAVGADLVGKTELPLGLLERAFVTADHPEQALREGECQQLSADRLGPQLAHLCADPAAAAGRQDTLSVFDSTGFAFEDALAMEVFLEAAAERDLGIRVGIEHHPGDALDPYALQ 5yu1 A 1.92 BS02 YCP A 1 R49 E63 M65 K77 I94 R121 A235 T302 G303 R49 E63 M65 K77 I94 R121 A235 T302 G303 4.3.1.12 29629557 METWVLGRRDVAEVVAAVGRDELMRRIIDRLTGGLAEIGRGERHLSPLRGGLERSEPVPGIWEWMPHREPGDHITLKTVGYSPANPARFGLPTILGTVARYDDTTGALTALMDGVLLTALRTGAASAVASRLLARPDSHTLGLIGTGAQAVTQLHALSLVLPLQRALVWDTDPAHRESFARRAAFTGVSVEIAEPARIAAEADVISTATSVAVGQGPVLPDTGVREHLHINAVGADLVGKTELPLGLLERAFVTADHPEQALREGECQQLSADRLGPQLAHLCADPAAAAGRQDTLSVFDSTGFAFEDALAMEVFLEAAAERDLGIRVGIEHHPGDALDPYALQ 5yu1 B 1.92 BS02 YCP B 1 R49 E63 M65 K77 V79 I94 T118 R121 A235 T302 G303 R49 E63 M65 K77 V79 I94 T118 R121 A235 T302 G303 4.3.1.12 29629557 METWVLGRRDVAEVVAAVGRDELMRRIIDRLTGGLAEIGRGERHLSPLRGGLERSEPVPGIWEWMPHREPGDHITLKTVGYSPANPARFGLPTILGTVARYDDTTGALTALMDGVLLTALRTGAASAVASRLLARPDSHTLGLIGTGAQAVTQLHALSLVLPLQRALVWDTDPAHRESFARRAAFTGVSVEIAEPARIAAEADVISTATSVAVGQGPVLPDTGVREHLHINAVGADLVGKTELPLGLLERAFVTADHPEQALREGECQQLSADRLGPQLAHLCADPAAAAGRQDTLSVFDSTGFAFEDALAMEVFLEAAAERDLGIRVGIEHHPGDALDPYALQ 5yu1 C 1.92 BS02 YCP C 1 E63 M65 K77 I94 T118 R121 A235 T302 G303 E63 M65 K77 I94 T118 R121 A235 T302 G303 4.3.1.12 29629557 METWVLGRRDVAEVVAAVGRDELMRRIIDRLTGGLAEIGRGERHLSPLRGGLERSEPVPGIWEWMPHREPGDHITLKTVGYSPANPARFGLPTILGTVARYDDTTGALTALMDGVLLTALRTGAASAVASRLLARPDSHTLGLIGTGAQAVTQLHALSLVLPLQRALVWDTDPAHRESFARRAAFTGVSVEIAEPARIAAEADVISTATSVAVGQGPVLPDTGVREHLHINAVGADLVGKTELPLGLLERAFVTADHPEQALREGECQQLSADRLGPQLAHLCADPAAAAGRQDTLSVFDSTGFAFEDALAMEVFLEAAAERDLGIRVGIEHHPGDALDPYALQ 5yu3 A 1.79 BS02 PRO A 1 R49 E63 M65 K77 R121 A235 T302 G303 R49 E63 M65 K77 R121 A235 T302 G303 4.3.1.12 29629557 METWVLGRRDVAEVVAAVGRDELMRRIIDRLTGGLAEIGRGERHLSPLRGGLERSEPVPGIWEWMPHREPGDHITLKTVGYSPANPARFGLPTILGTVARYDDTTGALTALMDGVLLTALRTGAASAVASRLLARPDSHTLGLIGTGAQAVTQLHALSLVLPLQRALVWDTDPAHRESFARRAAFTGVSVEIAEPARIAAEADVISTATSVAVGQGPVLPDTGVREHLHINAVGADLVGKTELPLGLLERAFVTADHPEQALREGECQQLSADRLGPQLAHLCADPAAAAGRQDTLSVFDSTGFAFEDALAMEVFLEAAAERDLGIRVGIEHHPGDALDPYALQ 5yu3 B 1.79 BS02 PRO B 1 R49 E63 M65 K77 V79 R121 A235 T302 G303 R49 E63 M65 K77 V79 R121 A235 T302 G303 4.3.1.12 29629557 METWVLGRRDVAEVVAAVGRDELMRRIIDRLTGGLAEIGRGERHLSPLRGGLERSEPVPGIWEWMPHREPGDHITLKTVGYSPANPARFGLPTILGTVARYDDTTGALTALMDGVLLTALRTGAASAVASRLLARPDSHTLGLIGTGAQAVTQLHALSLVLPLQRALVWDTDPAHRESFARRAAFTGVSVEIAEPARIAAEADVISTATSVAVGQGPVLPDTGVREHLHINAVGADLVGKTELPLGLLERAFVTADHPEQALREGECQQLSADRLGPQLAHLCADPAAAAGRQDTLSVFDSTGFAFEDALAMEVFLEAAAERDLGIRVGIEHHPGDALDPYALQ 5yu3 C 1.79 BS02 PRO C 1 E63 M65 K77 V79 R121 A235 T302 G303 E63 M65 K77 V79 R121 A235 T302 G303 4.3.1.12 29629557 METWVLGRRDVAEVVAAVGRDELMRRIIDRLTGGLAEIGRGERHLSPLRGGLERSEPVPGIWEWMPHREPGDHITLKTVGYSPANPARFGLPTILGTVARYDDTTGALTALMDGVLLTALRTGAASAVASRLLARPDSHTLGLIGTGAQAVTQLHALSLVLPLQRALVWDTDPAHRESFARRAAFTGVSVEIAEPARIAAEADVISTATSVAVGQGPVLPDTGVREHLHINAVGADLVGKTELPLGLLERAFVTADHPEQALREGECQQLSADRLGPQLAHLCADPAAAAGRQDTLSVFDSTGFAFEDALAMEVFLEAAAERDLGIRVGIEHHPGDALDPYALQ 5yu4 B 2.14 BS02 DAB B 1 R49 E63 M65 K77 I94 R121 A235 D236 T302 G303 R49 E63 M65 K77 I94 R121 A235 D236 T302 G303 4.3.1.12 29629557 METWVLGRRDVAEVVAAVGRDELMRRIIDRLTGGLAEIGRGERHLSPLRGGLERSEPVPGIWEWMPHREPGDHITLKTVGYSPANPARFGLPTILGTVARYDDTTGALTALMDGVLLTALRTGAASAVASRLLARPDSHTLGLIGTGAQAVTQLHALSLVLPLQRALVWDTDPAHRESFARRAAFTGVSVEIAEPARIAAEADVISTATSVAVGQGPVLPDTGVREHLHINAVGADLVGKTELPLGLLERAFVTADHPEQALREGECQQLSADRLGPQLAHLCADPAAAAGRQDTLSVFDSTGFAFEDALAMEVFLEAAAERDLGIRVGIEHHPGDALDPYALQ 5yug A 1.57 BS01 ZN A 1 C52 H56 H73 C76 C45 H49 H66 C69 SKMCMNASCGTTSTVEWKKGWPLRSGLLADLCYRCGSAYESSLFCEQFHKDQSGWRECYLCSKRLHCGCIASKVTIELMDYGGVGCSTCACC 5yug A 1.57 BS02 ZN A 2 C65 C68 C93 C96 C58 C61 C86 C89 SKMCMNASCGTTSTVEWKKGWPLRSGLLADLCYRCGSAYESSLFCEQFHKDQSGWRECYLCSKRLHCGCIASKVTIELMDYGGVGCSTCACC 5yw7 B 4.40 BS01 GBM B 1 R306 Y377 I381 F433 L434 N437 L592 T1242 R1246 R87 Y134 I138 F186 L187 N190 L345 T813 R817 29594720 VRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCVAFDAQARKDGARAIWRALCHAFGRRLILSSTFRILADLLGFAGPLCIFGIVDHLGKNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEHSNERLKQTNEMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSEIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHALLKTPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPETLLSQKDSVFASFVR 5yw7 B 4.40 BS02 AGS B 1 T404 W688 G716 C717 G718 K719 S720 S721 Q775 T161 W380 G408 C409 G410 K411 S412 S413 Q439 29594720 VRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCVAFDAQARKDGARAIWRALCHAFGRRLILSSTFRILADLLGFAGPLCIFGIVDHLGKNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEHSNERLKQTNEMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSEIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHALLKTPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPETLLSQKDSVFASFVR 5yw8 B 4.40 BS01 AGS B 1 T404 S405 W688 G716 C717 G718 K719 S720 S721 Q775 T330 S331 W545 G573 C574 G575 K576 S577 S578 Q604 29594720 NGCFVDALNVVPHVFLLFITFPILFIGWGSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKFYDHLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCVAFDAQARKDGARAIWRALCHAFGRRLILSSTFRILADLLGFAGPLCIFGIVDHLGKNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEHSNERLKQTNEMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFLSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSEIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHALLKTPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPETLLSQKDSVFASFVR 5ywc B 4.30 BS01 ADP B 1 W688 G716 G718 K719 S720 S721 Q775 E1480 S1483 W558 G586 G588 K589 S590 S591 Q617 E1223 S1226 29594720 NGCFVDALNVVPHVFLLFITFPILFIGWGSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKFYDHLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCVAFDAQARKGARAIWRALCHAFGRRLILSSTFRILADLLGFAGPLCIFGIVDHLGKNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEHSNERLKQTNEMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREECVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSERACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHALLKTEAESYEGPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPETLLSQKDSVFASFVR 5ywc B 4.30 BS02 ADP B 2 R1111 E1114 Y1354 G1382 S1383 G1384 K1385 S1386 S1387 R857 E860 Y1097 G1125 S1126 G1127 K1128 S1129 S1130 29594720 NGCFVDALNVVPHVFLLFITFPILFIGWGSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKFYDHLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCVAFDAQARKGARAIWRALCHAFGRRLILSSTFRILADLLGFAGPLCIFGIVDHLGKNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEHSNERLKQTNEMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREECVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSERACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHALLKTEAESYEGPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPETLLSQKDSVFASFVR 5yzy C 2.61 BS01 NUC A 1 R309 W349 P350 N351 R23 W63 P64 N65 LNLNIVPLFEKTLSASDAGRIGRLVLPKACAEAYFPPISQSEGIPLKIQDVRGREWTFQFRYWPNNNSRMYVLEGVTPCIQSMMLQAGDTVTFSRVDPGGKLIMGSRKAAN 5yzy C 2.61 BS02 NUC B 1 K297 S300 A301 S302 V311 P313 K314 N351 M356 K11 S14 A15 S16 V25 P27 K28 N65 M70 LNLNIVPLFEKTLSASDAGRIGRLVLPKACAEAYFPPISQSEGIPLKIQDVRGREWTFQFRYWPNNNSRMYVLEGVTPCIQSMMLQAGDTVTFSRVDPGGKLIMGSRKAAN 5yzz C 2.58 BS01 NUC A 1 R309 R347 W349 N351 N352 M356 R23 R61 W63 N65 N66 M70 LNLNIVPLFEKTLSASDAGRIGRLVLPKACAEAYFPPISQSEGIPLKIQDVRGREWTFQFRYWPNNNSRMYVLEGVTPCIQSMMLQAGDTVTFSRVDPGGKLIMGSRKAAN 5z00 C 2.59 BS01 NUC A 1 R306 I307 R309 R347 W349 P350 N351 M356 R20 I21 R23 R61 W63 P64 N65 M70 LNLNIVPLFEKTLSASDAGRIGRLVLPKACAEAYFPPISQSEGIPLKIQDVRGREWTFQFRYWPNNNSRMYVLEGVTPCIQSMMLQAGDTVTFSRVDPGGKLIMGSRKAAN 5z00 G 2.59 BS01 NUC E 1 R309 R347 W349 P350 N351 N352 M356 R23 R61 W63 P64 N65 N66 M70 LNLNIVPLFEKTLSASDAGRIGRLVLPKACAEAYFPPISQSEGIPLKIQDVRGREWTFQFRYWPNNNSRMYVLEGVTPCIQSMMLQAGDTVTFSRVDPGGKLIMGSRKAAN 5z00 K 2.59 BS02 NUC J 1 K297 S300 A301 S302 V311 P313 K314 W349 N351 S354 M356 K11 S14 A15 S16 V25 P27 K28 W63 N65 S68 M70 LNLNIVPLFEKTLSASDAGRIGRLVLPKACAEAYFPPISQSEGIPLKIQDVRGREWTFQFRYWPNNNSRMYVLEGVTPCIQSMMLQAGDTVTFSRVDPGGKLIMGSRKAAN 5z28 A 2.25 BS01 ZN A 1 C7 C12 C36 C39 C5 C10 C34 C37 AIKVCMNALCGAASTSGEWKKGWPMRSGDLASLCDKCGCAYEQSIFCEVFHAKESGWRECNSCDKRLHCGCIASRFMMELLENGGVTCISCAKKSG 5z28 A 2.25 BS02 ZN A 2 C49 H53 H70 C73 C47 H51 H68 C71 AIKVCMNALCGAASTSGEWKKGWPMRSGDLASLCDKCGCAYEQSIFCEVFHAKESGWRECNSCDKRLHCGCIASRFMMELLENGGVTCISCAKKSG 5z7j A 1.98 BS01 36J A 1 G35 L36 A105 S106 P131 M153 N156 S157 W185 Y189 P190 I193 P194 F222 H243 F244 G32 L33 A102 S103 P128 M150 N153 S154 W182 Y186 P187 I190 P191 F219 H240 F241 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5z7j C 1.98 BS01 36J C 1 G35 L36 A105 S106 P131 N134 L138 M153 N156 S157 A160 W185 Y189 P190 I193 P194 H243 G33 L34 A103 S104 P129 N132 L136 M151 N154 S155 A158 W183 Y187 P188 I191 P192 H241 ATRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5z7j D 1.98 BS01 36J D 1 G35 L36 A105 S106 P131 N134 M153 N156 W185 Y189 P190 I193 P194 F222 H243 F244 G33 L34 A103 S104 P129 N132 M151 N154 W183 Y187 P188 I191 P192 F220 H241 F242 ATRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5z7j E 1.98 BS01 36J E 1 G35 L36 A105 S106 P131 N134 L138 M153 S157 A160 W185 Y189 P190 I193 P194 F222 H243 F244 G33 L34 A103 S104 P129 N132 L136 M151 S155 A158 W183 Y187 P188 I191 P192 F220 H241 F242 ATRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYL 5z7j F 1.98 BS01 36J F 1 G35 L36 A105 S106 P131 N134 I137 M153 S157 W185 Y189 I193 P194 F222 H243 G32 L33 A102 S103 P128 N131 I134 M150 S154 W182 Y186 I190 P191 F219 H240 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5z7j G 1.98 BS01 36J G 1 G35 L36 A105 S106 M153 N156 S157 W185 Y189 P190 I193 P194 F222 H243 G33 L34 A103 S104 M151 N154 S155 W183 Y187 P188 I191 P192 F220 H241 ATRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYL 5z7j H 1.98 BS01 36J H 1 G35 L36 A105 S106 P131 N134 I137 M153 N156 S157 W185 P190 I193 P194 F222 H243 G32 L33 A102 S103 P128 N131 I134 M150 N153 S154 W182 P187 I190 P191 F219 H240 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5z97 A 2.32 BS01 ZER A 1 G35 L36 A105 S106 P131 N134 L138 M153 N156 W185 Y189 I193 P194 H243 F244 G32 L33 A102 S103 P128 N131 L135 M150 N153 W182 Y186 I190 P191 H240 F241 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5z97 C 2.32 BS01 ZER C 1 G35 L36 A105 S106 P131 N134 M153 W185 P190 I193 P194 F222 H243 G32 L33 A102 S103 P128 N131 M150 W182 P187 I190 P191 F219 H240 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5zcy A 1.50 BS01 NO2 A 1 R30 A31 R14 A15 29608219 VLKEQQRIKVYIERARYGKVKTIIEGIDEKEFDLEEIAKKLKAKLACGGTAKNGRIELQGDHRDRIKKLLAELGFSEELIEVE 6b0c A 3.51 BS01 GTP A 1 Q11 A12 Q15 E71 A99 A100 N101 S140 G143 G144 T145 P173 T179 N206 Y224 N228 Q11 A12 Q15 E71 A99 A100 N101 S140 G143 G144 T145 P173 T179 N206 Y224 N228 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDS 6b0c B 3.51 BS01 GDP B 1 Q11 C12 Q15 A97 N99 S138 G141 G142 T143 G144 N204 Y222 N226 Q11 C12 Q15 A97 N99 S138 G141 G142 T143 G144 N204 Y222 N226 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQY 6b0c C 3.51 BS01 GTP C 1 G10 Q11 A12 Q15 D98 A99 A100 N101 S140 G142 G143 G144 T145 G146 I171 T179 N206 Y224 N228 G10 Q11 A12 Q15 D98 A99 A100 N101 S140 G142 G143 G144 T145 G146 I171 T179 N206 Y224 N228 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVE 6b0c D 3.51 BS03 TA1 D 1 V23 E27 L215 D224 H227 L228 A231 P272 L273 T274 R276 P358 R359 L361 V23 E27 L215 D224 H227 L228 A231 P272 L273 T274 R276 P358 R359 L361 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDAT 6b0c K 3.51 BS01 MG K 1 T375 S488 T98 S211 SITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLENHKFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKNGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQVVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDLAGNERGVDTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYADRVKELVVK 6b0c K 3.51 BS02 ANP K 1 R284 P287 T370 G371 S372 G373 K374 T375 H376 F382 S487 S488 A516 R7 P10 T93 G94 S95 G96 K97 T98 H99 F105 S210 S211 A239 SITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLENHKFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKNGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQVVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDLAGNERGVDTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYADRVKELVVK 6b0i A 3.78 BS01 GTP A 1 G10 Q11 A12 Q15 D98 A99 N101 S140 G143 G144 T145 G146 I171 T179 E183 N206 Y224 N228 G10 Q11 A12 Q15 D98 A99 N101 S140 G143 G144 T145 G146 I171 T179 E183 N206 Y224 N228 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVE 6b0i B 3.78 BS02 GDP B 1 G10 Q11 C12 Q15 G142 G144 D177 N204 N226 G10 Q11 C12 Q15 G142 G144 D177 N204 N226 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDAT 6b0i B 3.78 BS03 TA1 B 1 V23 L215 D224 H227 L228 A231 S234 P272 L273 T274 R276 P358 R359 G360 L361 V23 L215 D224 H227 L228 A231 S234 P272 L273 T274 R276 P358 R359 G360 L361 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDAT 6b0l B 3.98 BS02 TA1 B 1 V23 L215 D224 H227 L228 S234 P272 L273 T274 R276 P358 R359 G360 V23 L215 D224 H227 L228 S234 P272 L273 T274 R276 P358 R359 G360 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDAT 6b0l K 3.98 BS01 ANP K 1 R286 P287 D340 T370 G371 G373 T375 H376 G384 S485 R41 P42 D95 T125 G126 G128 T130 H131 G139 S240 GNPNWETAQMIREYQSTLEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVDLTKFLENHKFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKNGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQVVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDLAGNERGVDTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYADRVKELVVK 6b8f A 1.06 BS05 CA A 3 H13 Q14 H9 Q10 1.16.3.1 TSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIQKPDEDDWESGLNAMEAALHLEKNVNQSLLELHKLATDKNDPHLADFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLG 6b8f A 1.06 BS06 CA A 4 A18 N21 A14 N17 1.16.3.1 TSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIQKPDEDDWESGLNAMEAALHLEKNVNQSLLELHKLATDKNDPHLADFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLG 6b8f A 1.06 BS08 CA A 6 K71 Q75 K67 Q71 1.16.3.1 TSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIQKPDEDDWESGLNAMEAALHLEKNVNQSLLELHKLATDKNDPHLADFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLG 6b8g A 1.13 BS07 CA A 5 E17 A18 N21 E13 A14 N17 1.16.3.1 TSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIQKPDEDDWESGLNAMEAALHLEKNVNQSLLELHKLATDKNDPHLADFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLG 6bb4 L 2.10 BS01 III P 1 T92 Y93 L94 F96 T92 Y93 L94 F96 29670132 DVQMIQSPSSLSASLGDIVTMTCQASQDTSINLNWFQQKPGKAPKLLIYGASNLEDGVPSRFSGSRYGTDFTLTISSLEDEDMATYFCLQHTYLPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR 6bb4 H 2.10 BS01 III P 1 T33 Y50 Y52 R95 G96 T97 T33 Y50 Y52 R99 G100 T101 29670132 QVQLQQSDAELVKPGASVKISCKASGYTFTDRTIHWVKQRPEQGLEWIGYIYPGDDSTKYNDMFKAKATLTADKSSNTAYMQLNSLTSDDSAVYFCARRGTMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD 6bb4 I 2.10 BS01 III Q 1 T33 Y52 R95 G96 T97 T33 Y52 R99 G100 T101 29670132 QVQLQQSDAELVKPGASVKISCKASGYTFTDRTIHWVKQRPEQGLEWIGYIYPGDDSTKYNDMFKAKATLTADKSSNTAYMQLNSLTSDDSAVYFCARRGTMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD 6bpl A 2.91 BS01 AU7 A 1 F157 L171 A175 V178 S179 I182 R190 A259 A262 M291 L294 M295 L298 K299 F154 L168 A172 V175 S176 I179 R187 A256 A259 M288 L291 M292 L295 K296 3.6.3.- DKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQ 6bpl A 2.91 BS02 GLC A 1 Y130 R310 Y127 R307 3.6.3.- DKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQ 6bpl B 2.91 BS01 AU7 B 1 F157 L171 I172 A175 V178 S179 I182 A259 M291 L294 M295 L298 K299 F151 L165 I166 A169 V172 S173 I176 A245 M277 L280 M281 L284 K285 3.6.3.- LSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQ 6bpp A 2.92 BS01 E1M A 1 L171 A175 V178 S179 I182 R190 I255 A259 M291 L294 M295 L298 K299 L168 A172 V175 S176 I179 R187 I252 A256 M288 L291 M292 L295 K296 3.6.3.- DKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQ 6bpp B 2.92 BS01 E1M B 1 F157 L171 A175 V178 I182 I255 A259 A262 L263 M291 L294 M295 L298 K299 T302 F150 L164 A168 V171 I175 I237 A241 A244 L245 M273 L276 M277 L280 K281 T284 3.6.3.- STWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQ 6bwj A 3.10 BS01 6EU A 1 Y469 S470 L473 S501 V504 M505 T508 L511 R515 S524 I531 L539 Q661 Y386 S387 L390 S418 V421 M422 T425 L428 R432 S441 I448 L456 Q544 LNRFDRDRLFNVVARGNPEDLAGLLEYLRRTSKYLTDSEYTEGSTGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLENPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYDGLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSAPCQSLSRKFTEWCYGPVRVSLYDLASVDSWEENSVLEIIAFHSRSPHRHRMVVLEPLNKLLQAKWDRLIPRFCFNFLCYLVYMLIFTAVAYHQAGNSMLLLGHILILLGGVYLLLGQLWYFWRRRLFIWISFMDSYSEILFLLQALLTVLSQVLCFLAIEWYLPLLVSSLVMGWTNLLYYTRGFQHTGIYSVMIEKVILRDLLRFLLVYLVFLFGFAVALVSLSRPPYRSILDASLELFKFTIGMGLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRRKKQRAGVMLTVGTRPDGSPDERWCFRVGEMNWATWEQTLPRTLCEEPSG 6bwj A 3.10 BS02 6EU B 1 F545 F549 L623 A626 L629 L630 F462 F466 L506 A509 L512 L513 LNRFDRDRLFNVVARGNPEDLAGLLEYLRRTSKYLTDSEYTEGSTGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLENPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYDGLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSAPCQSLSRKFTEWCYGPVRVSLYDLASVDSWEENSVLEIIAFHSRSPHRHRMVVLEPLNKLLQAKWDRLIPRFCFNFLCYLVYMLIFTAVAYHQAGNSMLLLGHILILLGGVYLLLGQLWYFWRRRLFIWISFMDSYSEILFLLQALLTVLSQVLCFLAIEWYLPLLVSSLVMGWTNLLYYTRGFQHTGIYSVMIEKVILRDLLRFLLVYLVFLFGFAVALVSLSRPPYRSILDASLELFKFTIGMGLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRRKKQRAGVMLTVGTRPDGSPDERWCFRVGEMNWATWEQTLPRTLCEEPSG 6bwj B 3.10 BS01 6EU B 1 F465 Y469 S470 L473 M505 T508 N509 L511 Y512 R515 S524 E528 I531 F385 Y389 S390 L393 M425 T428 N429 L431 Y432 R435 S444 E448 I451 NRFDRDRLFNVVARGNPEDLAGLLEYLRRTSKYLTDSEYTEGSTGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLENPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYDGLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSAPCQSLSRKFTEWCYGPVRVSLYDLASVDSWEENSVLEIIAFHSRSPHRHRMVVLEPLNKLLQAKWDRLIPRFCFNFLCYLVYMLIFTAVAYHQPALEAGNSMLLLGHILILLGGVYLLLGQLWYFWRRRLFIWISFMDSYSEILFLLQALLTVLSQVLCFLAIEWYLPLLVSSLVMGWTNLLYYTRGFQHTGIYSVMIEKVILRDLLRFLLVYLVFLFGFAVALVSLSRPPYRSILDASLELFKFTIGMGELAFQEFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRRKKQRAGVMLTVGTRPDGSPDERWCFRVGEMNWATWEQTLPRTLCEEPSG 6c01 A 2.30 BS01 ZN A 1 D325 H329 H483 D273 H277 H431 3.1.4.1,3.6.1.9 SCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTF 6c01 A 2.30 BS02 ZN A 2 D167 T205 D372 H373 D115 T153 D320 H321 3.1.4.1,3.6.1.9 SCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTF 6c01 A 2.30 BS03 CA A 1 D752 N754 D756 H758 F759 D760 D700 N702 D704 H706 F707 D708 3.1.4.1,3.6.1.9 SCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTF 6c01 A 2.30 BS04 FUC A 1 V661 S702 D703 Y706 V609 S650 D651 Y654 3.1.4.1,3.6.1.9 SCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTF 6c01 B 2.30 BS04 FUC B 1 P294 E297 P230 E233 3.1.4.1,3.6.1.9 SCRKKCFDASCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTF 6c02 A 1.94 BS02 ZN A 2 D167 A205 D372 H373 D111 A149 D316 H317 3.1.4.1,3.6.1.9 GSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKAFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLSLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTF 6c02 A 1.94 BS04 FUC A 1 H579 V661 S702 D703 Y706 H523 V605 S646 D647 Y650 3.1.4.1,3.6.1.9 GSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKAFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLSLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTF 6c02 A 1.94 BS06 FUC A 3 S791 H792 S735 H736 3.1.4.1,3.6.1.9 GSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKAFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLSLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTF 6c02 A 1.94 BS07 APC A 1 D167 K204 A205 F206 N226 L239 F270 W271 P272 E275 Y289 Y320 D325 H329 H483 D111 K148 A149 F150 N170 L183 F214 W215 P216 E219 Y233 Y264 D269 H273 H427 3.1.4.1,3.6.1.9 GSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKAFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLSLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTF 6c5x A 3.11 BS01 III G 1 R104 S106 K107 Q108 S125 I126 R127 D138 R46 S48 K49 Q50 S67 I68 R69 D80 29674694 RSHSDFTVITKTSSMLDTCGFYWGPMDVNVAHDKLKSEPIGTFLIRDSKQKNCFFAISVKTARETVSIRIKFHAGKFSLDKELFSCLFQLVEHYMTSPKKMLVSPLRKVRLRPLQELCRKSILATFGRQNLDSIPLNRVLKDYLKSFPFQI 6c7y A 2.50 BS01 ADP A 1 G882 G884 H885 F886 G887 V889 A906 K908 M956 E957 L959 S963 R1007 N1008 L1010 D1021 G15 G17 H18 F19 G20 V22 A36 K38 M77 E78 L80 S84 R128 N129 L131 D142 2.7.10.2 29674694 AHFEKRFLKRIRDLGEGHFGKVELCRYGDNTGEQVAVKSLKPHIADLKKEIEILRNLYHENIVKYKGICTEGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 6c7y A 2.50 BS03 MG A 2 F886 D1003 D1021 F19 D124 D142 2.7.10.2 29674694 AHFEKRFLKRIRDLGEGHFGKVELCRYGDNTGEQVAVKSLKPHIADLKKEIEILRNLYHENIVKYKGICTEGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 6ca4 A 1.62 BS01 MG A 1 D131 E161 D12 E42 3.1.4.- 29574079 SSKLSIISWNVDGLDTNNLSDRARGLCSYLALYTPDVVFLQELIPAYVQYLKKRAVSYLFFEGSDDGYFTGIMLRKSRVKFLESEIICFPTTQMMRNLLIAQVTFSGQKLYLMTSHLESTRNQSQERTKQLRVVLQKIKEAPEDAIVIFAGDTNLRDAEVANVGGLPAGVCDVWEQLGKQEHCRYTWDTQANACKLRFDRIFLRSAKTAPPVTPDHMALIGMEKLDCGRYTSDHWGIYCTFNT 6ccy A 2.18 BS01 EX4 A 1 L156 G157 G159 F161 G162 K163 V164 A177 K179 L181 T211 M227 E228 Y229 A230 E234 E278 M281 F438 F442 L16 G17 G19 F21 G22 K23 V24 A37 K39 L41 T71 M87 E88 Y89 A90 E94 E138 M141 F298 F302 2.7.11.1 29655979 GSLRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTESRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGPSDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSEVDTRYFDEEFTAQMITITEQEMFRDFDYIADWEG 6cf0 A 1.64 BS01 HEM A 1 T39 K42 F43 R45 T67 A71 L89 S92 H93 H97 I99 Y103 L104 F138 T39 K42 F43 R45 T67 A71 L89 S92 H93 H97 I99 Y103 L104 F138 VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKVGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGNFGADAQGAMNKALELFRKDIAAKYKELGYQG 6cf0 A 1.64 BS02 NO2 A 1 F43 V64 V68 F43 V64 V68 VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKVGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGNFGADAQGAMNKALELFRKDIAAKYKELGYQG 6cf0 A 1.64 BS04 NO2 A 3 E18 V21 E18 V21 VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKVGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGNFGADAQGAMNKALELFRKDIAAKYKELGYQG 6ckr A 1.62 BS01 F5V A 1 W81 P82 F83 Q85 P86 V87 D88 K91 L92 C136 N140 I146 W39 P40 F41 Q43 P44 V45 D46 K49 L50 C94 N98 I104 29657099 MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE 6ckr B 1.62 BS01 F5V B 1 W81 P82 F83 Q85 P86 V87 D88 K91 L92 L94 N140 W38 P39 F40 Q42 P43 V44 D45 K48 L49 L51 N97 29657099 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 6cnj A 3.40 BS01 NCT A 1 Y100 W156 C199 C200 Y204 Y96 W152 C195 C196 Y200 ETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRFERSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPW 6cnj A 3.40 BS02 Y01 A 1 C233 Y240 I366 C369 C229 Y236 I355 C358 ETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRFERSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPW 6cnj A 3.40 BS03 Y01 A 2 L293 I297 F300 L289 I293 F296 ETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRFERSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPW 6cnj B 3.40 BS01 NCT A 1 W57 F119 L121 W56 F118 L120 DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMF 6cnj B 3.40 BS02 Y01 B 1 F285 C292 F353 F284 C291 F342 DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMF 6cnj B 3.40 BS03 Y01 B 2 S225 I228 R351 W355 S224 I227 R340 W344 DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMF 6cnj C 3.40 BS01 Y01 C 1 Y232 R351 Y231 R340 DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMF 6cnj C 3.40 BS02 Y01 C 2 F285 V288 C292 F353 F284 V287 C291 F342 DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMF 6cnj D 3.40 BS01 NCT D 1 W156 T157 C199 C200 Y204 W152 T153 C195 C196 Y200 ETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRFERSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPW 6cnj D 3.40 BS02 Y01 D 1 C233 Y240 I366 C229 Y236 I355 ETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRFERSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPW 6cnj E 3.40 BS02 Y01 E 1 F285 C292 V296 F353 F284 C291 V295 F342 DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMF 6cnj E 3.40 BS03 Y01 E 2 S225 I228 Y232 R351 L354 W355 S224 I227 Y231 R340 L343 W344 DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMF 6cnk A 3.70 BS03 NCT A 1 W156 T157 C199 Y204 W152 T153 C195 Y200 ETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRFERSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPW 6cnk B 3.70 BS03 Y01 B 2 C233 V236 Y240 R359 W363 C225 V228 Y232 R344 W348 HAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRFERSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPW 6cnk D 3.70 BS01 NCT D 1 Y100 W156 Y197 C199 C200 Y204 Y96 W152 Y193 C195 C196 Y200 ETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRFERSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPW 6cnk D 3.70 BS03 Y01 D 2 L293 I297 F300 M364 L289 I293 F296 M353 ETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRFERSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPW 6cnk E 3.70 BS01 Y01 E 1 F285 C292 I349 F353 F284 C291 I338 F342 DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMF 6cnk E 3.70 BS02 Y01 E 2 S225 I228 R351 L354 W355 S224 I227 R340 L343 W344 DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMF 6co3 L 2.38 BS01 III Q 1 Y32 S91 Y92 S93 T94 Y32 S91 Y92 S93 T94 DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 6co3 H 2.38 BS01 III Q 1 W52 Y59 I102 R105 G107 P108 W52 Y59 I102 R105 G107 P108 QVQLVESGGGVVQPGRSLRLSCAASGFAFSSYGMHWVRQAPGKGLEWVAVIWFDGTKKYYTDSVKGRFTISRDNSKNTLYLQMNTLRAEDTAVYYCARDRGIGARRGPYYMDVWGKGTTVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK 6cu4 A 1.80 BS01 PYR A 1 R65 Y207 K213 Y286 R333 R60 Y202 K208 Y274 R321 4.1.1.49 GLTPQELEAYGISDVHDIVYNPSYDLLYQEELDPSLTGYERGVLTNLGAVAVDTGIFTGRSPKDKYIVRDDTTRDTFWWADKGKGKNDNKPLSPETWQHLKGLVTRQLSGKRLFVVDAFCGANPDTRLSVRFITEVAWQAHFVKNMFIRPSDEELAGFKPDFIVMNGAKCTNPQWKEQGLNSENFVAFNLTERMQLIGGTWYGGEMKKGMFSMMNYLLPLKGIASMHCSANVGEKGDVAVFFGLLSTDPKRRLIGDDEHGWDDDGVFNFEGGCYAKTIKLSKEAEPEIYNAIRRDALLENVTVREDGTIDFDDGSKTENTRVSYPIYHIDNIVKPVSKAGHATKVIFLTADAFGVLPPVSRLTADQTQYHFLSGFTAPTPTFSACFGAAFLSLHPTQYAEVLVKRMQAAGAQAYLVNTGWNGTGKRISIKDTRAIIDAILNGSLDNAETFTLPMFNLAIPTELPGVDTKILDPRNTYASPEQWQEKAETLAKLFIDNFDKYTDTPAGAALVAAGPKL 6cy5 A 1.70 BS01 GDP A 1 N124 G125 V126 G127 K128 T129 T130 K134 K269 D271 G294 V295 G296 E297 N122 G123 V124 G125 K126 T127 T128 K132 K267 D269 G292 V293 G294 E295 MVSWFKKIFKKEEKESLDKGLEKSSQSFFDKVSRAVVGKSKVDDEVLDDLEEVLIASDVGVETTVKIIRRIEERVARDKYVNVAELNNILREEISGLLLENPHAGTQNKTKKPYVIMVVGVNGVGKTTTIGKLAHQFKSEGLKVVLGAADTFRAAAVDQLVIWSERVGVPIVKQAMGSDPASVAFDTVQSAVSQDADVVIIDTAGRLHNKVNLMNELSKIKRVMQKVVPDAPHEVLLVLDGSTGQNAFEQAKQFTAATEVTALAVTKLDGTARGGVVIGISDQFQVPVKYIGVGEKMQDLQLFNGTEFVDSFFKKR 6cy5 A 1.70 BS02 GDP A 2 D181 S184 F187 D188 K221 V225 K228 D179 S182 F185 D186 K219 V223 K226 MVSWFKKIFKKEEKESLDKGLEKSSQSFFDKVSRAVVGKSKVDDEVLDDLEEVLIASDVGVETTVKIIRRIEERVARDKYVNVAELNNILREEISGLLLENPHAGTQNKTKKPYVIMVVGVNGVGKTTTIGKLAHQFKSEGLKVVLGAADTFRAAAVDQLVIWSERVGVPIVKQAMGSDPASVAFDTVQSAVSQDADVVIIDTAGRLHNKVNLMNELSKIKRVMQKVVPDAPHEVLLVLDGSTGQNAFEQAKQFTAATEVTALAVTKLDGTARGGVVIGISDQFQVPVKYIGVGEKMQDLQLFNGTEFVDSFFKKR 6d1x A 2.30 BS01 PA7 A 1 N107 A108 A111 D149 M154 N162 L163 T171 G196 V197 F199 Y200 T245 N35 A36 A39 D77 M82 N90 L91 T99 G124 V125 F127 Y128 T173 SEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTEKTVWDWELMN 6d1y A 1.93 BS01 FQJ A 1 S484 G485 L486 E560 L564 I572 M587 F646 H648 D668 F669 G670 S4 G5 L6 E77 L81 I89 M104 F154 H156 D176 F177 G178 2.7.10.1 29672039 GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 6d1z A 1.87 BS01 FQD A 1 L512 K513 W514 E515 F525 L22 K23 W24 E25 F35 2.7.10.1 29672039 GSGLQGHIIECVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 6d1z A 1.87 BS02 FQM A 1 S484 G485 L486 K544 E560 L564 I572 V573 M587 F589 F646 H648 G667 D668 G670 R673 S2 G3 L4 K54 E70 L74 I82 V83 M97 F99 F144 H146 G165 D166 G168 R171 2.7.10.1 29672039 GSGLQGHIIECVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 6d20 A 1.94 BS02 FQG A 1 G483 S484 G485 L486 K544 E560 L564 L567 I572 V573 M587 F589 F646 H648 I666 G667 D668 G670 R673 G2 S3 G4 L5 K57 E73 L77 L80 I85 V86 M100 F102 F148 H150 I168 G169 D170 G172 R175 2.7.10.1 29672039 KGSGLQGHIIENACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 6d24 A 3.35 BS01 BG6 A 1 K217 H247 Y248 K251 F283 E285 D304 H309 K403 R408 Q437 K166 H196 Y197 K200 F232 E234 D253 H258 K352 R357 Q386 1.1.1.49 VCERIPDAVSPELRSRALTIVVLGASGDLAKKKTFPALFQLYCNGMLPRDVNILGYARSTMEDVEKWKKDTLAGFFTRLDERGCHVGNFLRRISYMTGSYDRDEDFARLNERILRMEEAFQGPEKGGNRLFYLALPPSVFVGVCRGLSKGAMQKPELGWVRLIVEKPFGRDTETSEQLSNQLKPLFNERQVFRIDHYLGKEMVQNIIVTRFANRVFSALWNSNSIACVQITFKEKIGTEGRGGYFDSIGIIRDVIQNHLTQILSLLTMEKPRSLSAEDIRDEKVQVLRQVVPANPAECVLGQYTASADGSTPGYLDDPSVPKGSHCPTFAVLRLHVNNDRWHGVPFIIRAGKALEERLLDIRIQFKDEIRPFGESTQRNELVIRAQPSEAMYLKLTAKTPGLLNDTHQTELDLTYERRYDVTLPDAYESLIHEALLGNSTNFVRVDELDAAWRIYTPLLHAIDRGEVKVLPYAAGSCGPEEAQEFIRISGYKTTNGNAYKCS 6d24 C 3.35 BS01 BG6 C 1 K217 H247 Y248 K251 F283 E285 D304 V305 H309 R408 Q437 K166 H196 Y197 K200 F232 E234 D253 V254 H258 R357 Q386 1.1.1.49 VCERIPDAVSPELRSRALTIVVLGASGDLAKKKTFPALFQLYCNGMLPRDVNILGYARSTMEDVEKWKKDTLAGFFTRLDERGCHVGNFLRRISYMTGSYDRDEDFARLNERILRMEEAFQGPEKGGNRLFYLALPPSVFVGVCRGLSKGAMQKPELGWVRLIVEKPFGRDTETSEQLSNQLKPLFNERQVFRIDHYLGKEMVQNIIVTRFANRVFSALWNSNSIACVQITFKEKIGTEGRGGYFDSIGIIRDVIQNHLTQILSLLTMEKPRSLSAEDIRDEKVQVLRQVVPANPAECVLGQYTASADGSTPGYLDDPSVPKGSHCPTFAVLRLHVNNDRWHGVPFIIRAGKALEERLLDIRIQFKDEIRPFGESTQRNELVIRAQPSEAMYLKLTAKTPGLLNDTHQTELDLTYERRYDVTLPDAYESLIHEALLGNSTNFVRVDELDAAWRIYTPLLHAIDRGEVKVLPYAAGSCGPEEAQEFIRISGYKTT 6d5i A 1.80 BS01 ATP A 1 H232 L249 A250 G251 T252 G253 K254 T255 T256 D269 K288 E297 R333 T441 R449 I450 S451 I452 T455 H223 L240 A241 G242 T243 G244 K245 T246 T247 D260 K279 E288 R324 T432 R440 I441 S442 I443 T446 4.1.1.49 QELEAYGISDVHDIVYNPSYDLLYQEELDPSLTGYERGVLTNLGAVAVDTGIFTGRSPKDKYIVRDDTTRDTFWWADKGKGKNDNKPLSPETWQHLKGLVTRQLSGKRLFVVDAFCGANPDTRLSVRFITEVAWQAHFVKNMFIRPSDEELAGFKPDFIVMNGAKCTNPQWKEQGLNSENFVAFNLTERMQLIGGTWYGGEMKKGMFSMMNYLLPLKGIASMHCSANVGEKGDVAVFFGLAGTGKTTLSTDPKRRLIGDDEHGWDDDGVFNFEGGCYAKTIKLSKEAEPEIYNAIRRDALLENVTVREDGTIDFDDGSKTENTRVSYPIYHIDNIVKPVSKAGHATKVIFLTADAFGVLPPVSRLTADQTQYHFLSGFTAKLAGTERGITEPTPTFSACFGAAFLSLHPTQYAEVLVKRMQAAGAQAYLVNTGWNGTGKRISIKDTRAIIDAILNGSLDNAETFTLPMFNLAIPTELPGVDTKILDPRNTYASPEQWQEKAETLAKLFIDNFDKYTDTPAGAALVAAGPKL 6d5i A 1.80 BS02 PYR A 1 R65 Y207 K212 K213 Y286 R333 R56 Y198 K203 K204 Y277 R324 4.1.1.49 QELEAYGISDVHDIVYNPSYDLLYQEELDPSLTGYERGVLTNLGAVAVDTGIFTGRSPKDKYIVRDDTTRDTFWWADKGKGKNDNKPLSPETWQHLKGLVTRQLSGKRLFVVDAFCGANPDTRLSVRFITEVAWQAHFVKNMFIRPSDEELAGFKPDFIVMNGAKCTNPQWKEQGLNSENFVAFNLTERMQLIGGTWYGGEMKKGMFSMMNYLLPLKGIASMHCSANVGEKGDVAVFFGLAGTGKTTLSTDPKRRLIGDDEHGWDDDGVFNFEGGCYAKTIKLSKEAEPEIYNAIRRDALLENVTVREDGTIDFDDGSKTENTRVSYPIYHIDNIVKPVSKAGHATKVIFLTADAFGVLPPVSRLTADQTQYHFLSGFTAKLAGTERGITEPTPTFSACFGAAFLSLHPTQYAEVLVKRMQAAGAQAYLVNTGWNGTGKRISIKDTRAIIDAILNGSLDNAETFTLPMFNLAIPTELPGVDTKILDPRNTYASPEQWQEKAETLAKLFIDNFDKYTDTPAGAALVAAGPKL 6d6j A 1.35 BS01 ZN A 1 C3 C6 H45 H97 C2 C5 H44 H96 NCLFCKIAQGEIPATVVFEDKNILAFRDIRPQAPTHLLIIPKKHIATINDVNDDDSELLANILIRAKKLAQAEGLSEMGYRLVFNVNSGGGQEVYHIHLHLLGGRQMTWPPG 6ein A 2.11 BS01 B7Z A 1 Y425 D428 I479 C480 G481 M482 Y488 F496 H499 E501 K517 W519 H587 Y123 D126 I174 C175 G176 M177 Y183 F191 H194 E196 K212 W214 H272 1.14.11.-,1.14.11.- MFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAES 6eiu A 1.88 BS02 MN A 1 L90 N91 L413 T416 E419 L66 N67 L116 T119 E122 1.14.11.-,1.14.11.- MFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAES 6eiu A 1.88 BS04 B6T A 1 R98 Y425 A427 Y488 S495 F496 H499 N509 K517 W519 H587 N591 R74 Y128 A130 Y188 S195 F196 H199 N209 K217 W219 H287 N291 1.14.11.-,1.14.11.- MFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAES 6eiy A 2.15 BS04 B6W A 1 Q88 Q96 T97 R98 Y425 G426 Y488 S494 S495 F496 C497 H499 N509 K517 V553 H587 N591 Q64 Q72 T73 R74 Y128 G129 Y190 S196 S197 F198 C199 H201 N211 K219 V255 H289 N293 1.14.11.-,1.14.11.- MFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAES 6ej0 A 2.06 BS04 B7K A 1 R86 R98 Y425 G426 W486 Y488 S495 F496 H499 N509 K517 W519 H587 N591 R62 R74 Y125 G126 W185 Y187 S194 F195 H198 N208 K216 W218 H286 N290 1.14.11.-,1.14.11.- MFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRRDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAES 6ej7 A 2.00 BS01 III B 1 K449 H451 K461 Q462 R466 R477 S493 E529 W555 R557 W571 C572 G573 C574 K198 H200 K210 Q211 R215 R226 S242 E278 W304 R306 W320 C321 G322 C323 2.4.2.26 29681470 DQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR 6ej7 A 2.00 BS02 UDX A 1 V333 V334 H335 D361 R363 T390 W392 S423 D494 W495 L526 E529 T553 S575 P576 R598 K599 V82 V83 H84 D110 R112 T139 W141 S172 D243 W244 L275 E278 T302 S324 P325 R347 K348 2.4.2.26 29681470 DQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR 6ej8 A 2.09 BS01 III B 1 W392 K449 H451 K461 Q462 R466 R477 S493 L526 E529 W555 R557 W571 C572 G573 C574 W140 K197 H199 K209 Q210 R214 R225 S241 L274 E277 W303 R305 W319 C320 G321 C322 2.4.2.26 29681470 DQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR 6eja A 1.94 BS01 III B 1 W392 K449 H451 F458 K461 Q462 R477 G492 L526 E529 W555 R557 W571 C572 G573 C574 W134 K191 H193 F200 K203 Q204 R219 G234 L268 E271 W297 R299 W313 C314 G315 C316 2.4.2.26 29681470 QPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR 6ejb A 2.56 BS01 III B 1 K449 H451 K461 Q462 R466 G492 S493 L526 E529 W555 R557 W571 C572 C574 K198 H200 K210 Q211 R215 G241 S242 L275 E278 W304 R306 W320 C321 C323 2.4.2.26 29681470 DQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIAGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR 6ejc A 2.06 BS01 III B 1 W392 H451 K461 Q462 R466 R477 G492 S493 L526 E529 N549 T553 W555 R557 W571 C572 G573 C574 W138 H197 K207 Q208 R212 R223 G238 S239 L272 E275 N295 T299 W301 R303 W317 C318 G319 C320 2.4.2.26 29681470 QPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIADFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR 6ejd A 2.68 BS01 III B 1 K449 S450 H451 K461 Q462 G492 S493 L526 E529 W555 R557 W571 C572 C574 K188 S189 H190 K200 Q201 G231 S232 L265 E268 W294 R296 W310 C311 C313 2.4.2.26 29681470 QPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR 6eje A 2.43 BS01 III B 1 W392 K449 H451 K461 Q462 R466 G492 S493 E529 W555 R557 W571 C572 G573 C574 W134 K191 H193 K203 Q204 R208 G234 S235 E271 W297 R299 W313 C314 G315 C316 2.4.2.26 29681470 QPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR 6ely A 2.84 BS01 BFW A 1 Y76 G113 S114 Y115 E119 R125 L157 E165 E196 Y76 G113 S114 Y115 E119 R125 L157 E165 E196 YERLSLRTVQQTTGAEYFSFITLLRDFVSSGSFSNNIPLLRQSTIPVSEGSRFVLVELTNAGGDSVTAAIDVTNLYVVAYQAGQQSYFLKDAPAGAETQDFTGTTRSSLPFNGSYPDLERYAGHRDQIPLGIDQLIQSVTALRFPGGSTRTQARSILILIQMISEAARFDPILWRARQYINSGASFLPDVYMLELETSWGQQSTQVQHSTDGVFNNPIRLALSPGNVVTLTNVRDVIASLAIMLFVCGE 6ely B 2.84 BS01 GLY A 1 G147 F148 R149 M258 G147 F148 R149 M258 DDVTCSASEPTVRIVGRNGMTVDVRDDDFQDGNQIQLWPSKSNNDPNQLWTIKKDGTIRSNGSCLTTYGYTAGVYVMIFDCNTAVREATIWQIWGNGTIINPRSNLVLAASSGIKGTTLTVQTLDYTLGQGWLAGNDTAPREVTIYGFRDLCMESAGGSVWVETCTAGQENQRWALYGDGSIRPKQNQSQCLTNGRDSVSTVINIVSCSAGSSGQRWVFTNAGAILNLKNGLAMDVAQANPALARIIIYPATGNPNQMWLPVP 6enk A 1.96 BS01 BJ5 A 1 W122 F143 W150 S229 Y236 S238 W270 F271 R292 S294 R320 P322 W71 F92 W99 S178 Y185 S187 W219 F220 R241 S243 R269 P271 29685972 PWSFKDDRGTTVKLDKVPANIVAFTGVAAALFDYGVEVKGVFGPTTTKDGKPDVQAGDLDVDKVTVLGNEWGKLNVEKYASLAPEVLITTTFDTAGTLWSVPEESKDKVAKLAPSVAISVFDRQLTQPLQRMWELAESLGADMKAKKVTDAKAAFDKAAARLRAAAKAKPEIRVLAGSASPDLFYVSGTNLSVDLEYFKALGVNFVEPSEDAKKATGGWFESLSWENVDKYPADVIIMDDRASTIQPADITEGTWKQLPAVKAGQVIARSPEPILSYDKCTPLLDNLAEAIENAKKVG 6eph B 2.70 BS01 EPZ B 1 S6 N9 A55 D56 K59 N75 H79 N80 A83 V84 S87 K115 G134 Q135 S141 K145 I187 S5 N8 A54 D55 K58 N74 H78 N79 A82 V83 S86 K114 G133 Q134 S140 K144 I186 VKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHNSAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVAVSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQEQILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGIYLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSA 6eph H 2.70 BS01 EPZ H 1 S6 D7 N9 A55 D56 K59 N75 H79 N80 A83 V84 S87 K115 G134 Q135 S141 K145 I187 S5 D6 N8 A54 D55 K58 N74 H78 N79 A82 V83 S86 K114 G133 Q134 S140 K144 I186 VKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHNSAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVAVSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQEQILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGIYLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSA 6epi B 2.80 BS01 BNW B 1 S6 N9 A55 D56 K59 N75 H79 N80 A83 V84 S87 P111 K115 G134 Q135 S141 K145 R175 R181 A183 I187 S5 N8 A54 D55 K58 N74 H78 N79 A82 V83 S86 P110 K114 G133 Q134 S140 K144 R174 R180 A182 I186 VKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHNSAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVAVSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQEQILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGIYLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSA 6epi D 2.80 BS01 BNW D 1 S6 N9 A55 K59 N75 H79 N80 A83 V84 S87 P111 K115 Q135 S141 K145 R175 R181 I187 S5 N8 A54 K58 N74 H78 N79 A82 V83 S86 P110 K114 Q134 S140 K144 R174 R180 I186 VKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHNSAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVAVSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQEQILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGIYLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSA 6er3 A 1.37 BS01 SIA A 1 I54 E85 R87 K94 R163 Y169 I48 E79 R81 K88 R152 Y158 29259165 GSVLQKEGIEISEGTGYDLSKEPGAATVKALEQGTIVISYKTTSENAIQSLLSVGNGTKGNQDRHFHLYITNAGGVGMELRNTDGEFKYTLDCPAAVRGSVSNTVALKADKENKQYKLFANGELIATLDQEAFKFISDITGVDNVMLGGTMRQGTVAYPFGGSIERMQVYRDVLSDDELIAVTG 6er4 A 1.30 BS02 BGC A 1 D110 D131 D67 D88 29259165 MADIGSVLQKEGIEISEGTGYDLSKEPGAATVKALEQGTIVISYKTTSENAIQSLLSVGNGTKGNQDRHFHLYITNAGGVGMELRNTDGEFKYTLDCPAAVRGSYKGERVSNTVALKADKENKQYKLFANGELIATLDQEAFKFISDITGVDNVMLGGTMRQGTVAYPFGGSIERMQVYRDVLSDDELIAVTGK 6er4 B 1.30 BS01 SIA B 1 I95 Y116 E126 R128 K135 R204 Y210 I48 Y69 E79 R81 K88 R157 Y163 29259165 GSVLQKEGIEISEGTGYDLSKEPGAATVKALEQGTIVISYKTTSENAIQSLLSVGNGTKGNQDRHFHLYITNAGGVGMELRNTDGEFKYTLDCPAAVRGSYKGERVSNTVALKADKENKQYKLFANGELIATLDQEAFKFISDITGVDNVMLGGTMRQGTVAYPFGGSIERMQVYRDVLSDDELIAVTG 6esb 1 3.40 BS01 SIA 1 1 L62 F65 L67 K68 F270 N272 S274 T276 Q278 L49 F52 L54 K55 F257 N259 S261 T263 Q265 PKKPKEPVQVPKLLIKGGVEVLEVKTGVDAITEVECFLNPEMGDPDENLRGFSLKLSAENDFSSDSPERKMLPCYSTARIPLPNLNEDLTCGNLLMWEAVTVQTEVIGITSMLNLHAGSQKVHEHGGGKPIQGSNFHFFAVGGDPLEMQGVLMNYRTKYPDGTITPKNPTAQSQVMNTDHKAYLDKNNAYPVECWVPDPSRNENTRYFGTFTGGENVPPVLHVTNTATTVLLDEQGVGPLCKADSLYVSAADICGLFTNSSGTQQWRGLARYFKIRLRKRSVKNPYPISFLLSDLINRRTQRVDGQPMYGMESQVEEVRVFDGTERLPGDPDMIRYIDKQGQLQTKM 6esb 1 3.40 BS02 SIA 1 2 K68 T276 K55 T263 PKKPKEPVQVPKLLIKGGVEVLEVKTGVDAITEVECFLNPEMGDPDENLRGFSLKLSAENDFSSDSPERKMLPCYSTARIPLPNLNEDLTCGNLLMWEAVTVQTEVIGITSMLNLHAGSQKVHEHGGGKPIQGSNFHFFAVGGDPLEMQGVLMNYRTKYPDGTITPKNPTAQSQVMNTDHKAYLDKNNAYPVECWVPDPSRNENTRYFGTFTGGENVPPVLHVTNTATTVLLDEQGVGPLCKADSLYVSAADICGLFTNSSGTQQWRGLARYFKIRLRKRSVKNPYPISFLLSDLINRRTQRVDGQPMYGMESQVEEVRVFDGTERLPGDPDMIRYIDKQGQLQTKM 6esb 1 3.40 BS03 CA 1 1 S213 E216 S200 E203 PKKPKEPVQVPKLLIKGGVEVLEVKTGVDAITEVECFLNPEMGDPDENLRGFSLKLSAENDFSSDSPERKMLPCYSTARIPLPNLNEDLTCGNLLMWEAVTVQTEVIGITSMLNLHAGSQKVHEHGGGKPIQGSNFHFFAVGGDPLEMQGVLMNYRTKYPDGTITPKNPTAQSQVMNTDHKAYLDKNNAYPVECWVPDPSRNENTRYFGTFTGGENVPPVLHVTNTATTVLLDEQGVGPLCKADSLYVSAADICGLFTNSSGTQQWRGLARYFKIRLRKRSVKNPYPISFLLSDLINRRTQRVDGQPMYGMESQVEEVRVFDGTERLPGDPDMIRYIDKQGQLQTKM 6esb 2 3.40 BS02 SIA 2 1 F65 L67 K68 F270 N272 S274 T276 Q278 F52 L54 K55 F257 N259 S261 T263 Q265 PKKPKEPVQVPKLLIKGGVEVLEVKTGVDAITEVECFLNPEMGDPDENLRGFSLKLSAENDFSSDSPERKMLPCYSTARIPLPNLNEDLTCGNLLMWEAVTVQTEVIGITSMLNLHAGSQKVHEHGGGKPIQGSNFHFFAVGGDPLEMQGVLMNYRTKYPDGTITPKNPTAQSQVMNTDHKAYLDKNNAYPVECWVPDPSRNENTRYFGTFTGGENVPPVLHVTNTATTVLLDEQGVGPLCKADSLYVSAADICGLFTNSSGTQQWRGLARYFKIRLRKRSVKNPYPISFLLSDLINRRTQRVDGQPMYGMESQVEEVRVFDGTERLPGDPDMIRYIDKQGQLQTK 6esb 4 3.40 BS02 SIA 4 1 L62 F65 L67 K68 N272 S274 T276 Q278 L46 F49 L51 K52 N256 S258 T260 Q262 PKEPVQVPKLLIKGGVEVLEVKTGVDAITEVECFLNPEMGDPDENLRGFSLKLSAENDFSSDSPERKMLPCYSTARIPLPNLNEDLTCGNLLMWEAVTVQTEVIGITSMLNLHAGSQKVHEHGGGKPIQGSNFHFFAVGGDPLEMQGVLMNYRTKYPDGTITPKNPTAQSQVMNTDHKAYLDKNNAYPVECWVPDPSRNENTRYFGTFTGGENVPPVLHVTNTATTVLLDEQGVGPLCKADSLYVSAADICGLFTNSSGTQQWRGLARYFKIRLRKRSVKNPYPISFLLSDLINRRTQRVDGQPMYGMESQVEEVRVF 6esb 6 3.40 BS01 III 7 1 V113 Q116 N238 T239 A240 T241 L245 G249 V99 Q102 N224 T225 A226 T227 L231 G235 KKPKEPVQVPKLLIKGGVEVLEVKTGVDAITEVECFLNPEMGDPDENLRGFSLKLSAENDFSSDSPERKMLPCYSTARIPLPNLNEDLTCGNLLMWEAVTVQTEVIGITSMLNLHAGSQKVHEHGGGKPIQGSNFHFFAVGGDPLEMQGVLMNYRTKYPDGTITPKNPTAQSQVMNTDHKAYLDKNNAYPVECWVPDPSRNENTRYFGTFTGGENVPPVLHVTNTATTVLLDEQGVGPLCKADSLYVSAADICGLFTNSSGTQQWRGLARYFKIRLRKRSVKNPYPISFLLSDLINRRTQRVDGQPMYGMESQVEEVRVFDGTERLPGDPDMIRYIDKQGQLQTK 6esb 6 3.40 BS03 SIA 6 1 L62 L67 K68 N272 T276 Q278 L48 L53 K54 N258 T262 Q264 KKPKEPVQVPKLLIKGGVEVLEVKTGVDAITEVECFLNPEMGDPDENLRGFSLKLSAENDFSSDSPERKMLPCYSTARIPLPNLNEDLTCGNLLMWEAVTVQTEVIGITSMLNLHAGSQKVHEHGGGKPIQGSNFHFFAVGGDPLEMQGVLMNYRTKYPDGTITPKNPTAQSQVMNTDHKAYLDKNNAYPVECWVPDPSRNENTRYFGTFTGGENVPPVLHVTNTATTVLLDEQGVGPLCKADSLYVSAADICGLFTNSSGTQQWRGLARYFKIRLRKRSVKNPYPISFLLSDLINRRTQRVDGQPMYGMESQVEEVRVFDGTERLPGDPDMIRYIDKQGQLQTK 6eut A 1.90 BS01 BY8 A 1 Q61 Y62 Y63 K64 F67 K122 Y126 Q146 I149 V153 W224 C229 Q60 Y61 Y62 K63 F66 K121 Y125 Q145 I148 V152 W223 C228 29667825 NAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSGIAHSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN 6euu A 2.60 BS01 K29 B 1 F131 F134 F131 F134 29667825 MNAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN 6euu B 2.60 BS01 K29 B 1 L60 Q61 K130 F134 S142 L59 Q60 K129 F133 S141 29667825 NAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN 6euz A 1.95 BS01 C8Q B 1 S127 K130 F131 S126 K129 F130 29667825 NAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN 6euz B 1.95 BS01 C8Q B 1 L60 Q61 Y62 Y126 K130 F131 F134 S142 S177 S178 G179 L59 Q60 Y61 Y125 K129 F130 F133 S141 S176 S177 G178 29667825 NAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSGIAHSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN 6ev0 A 2.30 BS01 BYK A 1 I45 Q61 Y62 Y63 K64 F67 K122 Y126 I149 L150 W224 C229 I44 Q60 Y61 Y62 K63 F66 K121 Y125 I148 L149 W217 C222 29667825 NAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN 6ev0 A 2.30 BS02 C8N B 1 L60 K130 F131 F134 S142 L59 K129 F130 F133 S141 29667825 NAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN 6ev0 B 2.30 BS01 BYK B 1 Q61 Y62 Y63 K64 F67 Y126 I149 L150 V153 W224 C229 Q60 Y61 Y62 K63 F66 Y125 I148 L149 V152 W223 C228 29667825 NAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSGIAHSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN 6ewq A 2.20 BS01 PLP A 1 S57 A58 T59 Y84 A86 V129 D170 A172 H173 S194 K199 G206 Y345 S54 A55 T56 Y81 A83 V126 D167 A169 H170 S191 K196 G203 Y342 29669826 YNIPFSPPDITEAEITEVVDTLRSGWITTGPKTKELERRLSLYTQTPKTVCLNSATAALELILRVLEVGPGDEVIVPAMTYTASCSVITHVGATPVMVDIQADTFEMDYDLLEQAITEKTKVIIPVELAGIVCDYDRLFQVVEKKRDFFTASSKWQKAFNRIVIVSDSAHALGSTYKGQPSGSIADFTSFSFHAVKNFTTAEGGSATWKANPVIDDEEMYKEFQILSLHGQTKDALAKMQLGSWEYDIVTPAYKCNMTDIMASLGLVQLDRYPSLLQRRKDIVDRYDSGFAGSRIHPLAHKTETVESSRHLYITRVEGASLEERNLIIQELAKAGIASNVHYKPLPLLTAYKNLGFDMTNYPKAYAFFENEITLPLHTKLSDEEVDYIIETFKTVSEKVLT 6ewr B 2.40 BS01 PMP B 1 S57 A58 T59 Y84 A86 D170 A172 H173 S194 K199 Y345 S54 A55 T56 Y81 A83 D167 A169 H170 S191 K196 Y333 29669826 YNIPFSPPDITEAEITEVVDTLRSGWITTGPKTKELERRLSLYTQTPKTVCLNSATAALELILRVLEVGPGDEVIVPAMTYTASCSVITHVGATPVMVDIQADTFEMDYDLLEQAITEKTKVIIPVELAGIVCDYDRLFQVVEKKRDFFTASSKWQKAFNRIVIVSDSAHALGSTYKGQPSGSIADFTSFSFHAVKNFTTAEGGSATWKANPVIDDEEMYKEFQILSLHGQTKSWEYDIVTPAYKCNMTDIMASLGLVQLDRYPSLLQRRKDIVDRYDSGFAGSRIHPLAHKTETVESSRHLYITRVEGASLEERNLIIQELAKAGIASNVHYKPLPLLTAYKNLGFDMTNYPKAYAFFENEITLPLHTKLSDEEVDYIIETFKTVSEKVLTLSKK 6exl B 1.90 BS01 C2Q B 1 I45 Y62 Y63 K64 F67 K122 Y126 Q146 I149 L150 W224 C229 I46 Y63 Y64 K65 F68 K123 Y127 Q147 I150 L151 W218 C223 29667825 AMNAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN 6exm B 1.60 BS01 QQH B 1 Y62 Y63 K64 F67 K122 Y126 L150 W224 C229 Y61 Y62 K63 F66 K121 Y125 L149 W216 C221 29667825 NAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN 6f0x A 4.60 BS01 AGS A 1 S138 L139 V140 Y141 G182 T183 G184 K185 T186 S187 N300 I330 G385 R386 R389 S17 L18 V19 Y20 G61 T62 G63 K64 T65 S66 N179 I209 G264 R265 R268 ANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDQVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALSLAVDKQFEERKKLA 6f0x B 4.60 BS01 AGS B 1 S138 L139 V140 Y141 T183 G184 K185 T186 N300 P322 G385 R386 R389 S107 L108 V109 Y110 T152 G153 K154 T155 N269 P291 G354 R355 R358 PTVHVEVHQRGSSTAKKEDINLSVRKLLNRHNIGDYTWTEFDEPFLTRNVQSVSIIDDLSACTVALHIFQLNEDGPSSENLEEETENIIAANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDQVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALSLAVDKQFEERKKLA 6f0x C 4.60 BS01 AGS C 1 S138 L139 P181 G182 T183 G184 K185 T186 S187 N300 P322 I330 G385 R386 R389 S107 L108 P150 G151 T152 G153 K154 T155 S156 N269 P291 I299 G354 R355 R358 PTVHVEVHQRGSSTAKKEDINLSVRKLLNRHNIGDYTWTEFDEPFLTRNVQSVSIIDDLSACTVALHIFQLNEDGPSSENLEEETENIIAANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDQVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALSLAVDKQFEERKKLA 6f0x D 4.60 BS01 AGS D 1 S138 L139 V140 G182 T183 G184 K185 T186 S187 I330 G385 R386 R389 S107 L108 V109 G151 T152 G153 K154 T155 S156 I299 G354 R355 R358 PTVHVEVHQRGSSTAKKEDINLSVRKLLNRHNIGDYTWTEFDEPFLTRNVQSVSIIDDLSACTVALHIFQLNEDGPSSENLEEETENIIAANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDQVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALSLAVDKQFEERKKLA 6f0x Z 4.60 BS01 III Q 1 Y38 E60 L61 Y64 D152 L153 L154 I155 Y156 T157 D160 K166 W167 E168 E169 S170 G171 P172 Y37 E59 L60 Y63 D151 L152 L153 I154 Y155 T156 D159 K165 W166 E167 E168 S169 G170 P171 ALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND 6f6r A 1.80 BS01 CVE A 1 R179 Q283 C285 R62 Q166 C168 3.4.22.36 29648825 QDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD 6f8z A 2.50 BS01 CA A 1 G593 N594 E595 D637 G573 N574 E575 D617 QAGEITKYVNPFIGTGAIDGGLSGNNYPGATSPFGMIQLSPDTSEAPNWGDASGYDYNRNTIFGFSHTRLSGTGASDLIDITLMPTSSGRTSSAFTHDEEKARPGYYQVMLKDENINAELTTTQRNGIHRYQYPAGKDAEIILDMDHSADKGSWGRRIINSQIRILNDHAVEGYRIITGWAKLRKIYFYMEFSSPILTSTLRDGGRVHENTAVINGTNLHGCFRFGQLNGKPLTCKVALSSVSMENARQNMEQEAPHWDFDRYVAAADADWEKQLGKIEVKGTEVQKEIFYTALYHTMIQPNTMSDVNGEYMAADYTTRKVANNETHYTTFSLWDTFRASHPLYTLLEPERVTDFVKSMIRQYEYYGYLPIWQLWGQDNYCMIGNHSIPVITDAILKGIPGIDMEKAYEAVYNSSVTSHPNSPFEVWEKYGFMPENIQTQSVSITLEQAFDDWCVAQLAAKLNKDADYQRFHKRSEYYRNLFHPKTKFFQSKNDKGEWIEPFDPYQYGGNGGHPFTEGNAWQYFWYVPHNIQALMELTGGTKAFEQKLDTFFTSTYKSMNHNASGFVGQYAHGNEPSHHVAYLYNFAGQPWKTQKYVSHILNTLYNNTSSGYAGNDDCGQMSAWYVFSAMGFYPVNPADGRYIIGSPLLDECTLKLAGNKEFRIRTIRKSPEDIYIQSVTLNGKKHKDFFITHQDIMNGGTMVFKMGKKPSGWGK 6f8z B 2.50 BS01 CA B 1 G593 E595 D637 G562 E564 D606 QAGEITKYVNPFIGTGAIDGGLSGNNYPGATSPFGMIQLSPDTSEAPNWGDASGYDYNRNTIFGFSHTRLSGTGASDLIDITLMPTSSGRTSSAFTHDEEKARPGYYQVMLKDENINAELTTTQRNGIHRYQYPAGKDAEIILDMDHSADKGSWGRRIINSQIRILNDHAVEGYRIITGWAKLRKIYFYMEFSSPILTSTLRDGGRVHENTAVINGTNLHGCFRFGQLNGKPLTCKVALSSVSMENARQNMEQEAPHWDFDRYVAAADADWEKQLGKIEVKGTEVQKEIFYTALYHTMIQPNTMSDVNGEYMAADYTTRKVANNETHYTTFSLWDTFRASHPLYTLLEPERVTDFVKSMIRQYEYYGYLPIWQLWGQDNYCMIGNHSIPVITDAILKGIPGIDMEKAYEAVYNSSVTSHPNSPFEVWEKYGFMPENIQTQSVSITLEQAFDDWCVAQLAAKLNKDADYQRFHKRSEYYRNLFHPKTKFFQSKNDKGEWIEPFDPYQYGGHPFTEGNAWQYFWYVPHNIQALMELTGGTKAFEQKLDTFFTSTYGFVGQYAHGNEPSHHVAYLYNFAGQPWKTQKYVSHILNTLYNNTSSGYAGNDDCGQMSAWYVFSAMGFYPVNPADGRYIIGSPLLDECTLKLAGNKEFRIRTIRKSPEDIYIQSVTLNGKKHKDFFITHQDIMNGGTMVFKMGKKPSGWG 6f90 A 2.40 BS01 CA A 1 N594 E595 D637 N573 E574 D616 AGEITKYVNPFIGTGAIDGGLSGNNYPGATSPFGMIQLSPDTSEAPNWGDASGYDYNRNTIFGFSHTRLSGTGASDLIDITLMPTSSGRTSSAFTHDEEKARPGYYQVMLKDENINAELTTTQRNGIHRYQYPAGKDAEIILDMDHSADKGSWGRRIINSQIRILNDHAVEGYRIITGWAKLRKIYFYMEFSSPILTSTLRDGGRVHENTAVINGTNLHGCFRFGQLNGKPLTCKVALSSVSMENARQNMEQEAPHWDFDRYVAAADADWEKQLGKIEVKGTEVQKEIFYTALYHTMIQPNTMSDVNGEYMAADYTTRKVANNETHYTTFSLWDTFRASHPLYTLLEPERVTDFVKSMIRQYEYYGYLPIWQLWGQDNYCMIGNHSIPVITDAILKGIPGIDMEKAYEAVYNSSVTSHPNSPFEVWEKYGFMPENIQTQSVSITLEQAFDDWCVAQLAAKLNKDADYQRFHKRSEYYRNLFHPKTKFFQSKNDKGEWIEPFDPYQYGGNGGHPFTEGNAWQYFWYVPHNIQALMELTGGTKAFEQKLDTFFTSTYKSMNHNASGFVGQYAHGNEPSHHVAYLYNFAGQPWKTQKYVSHILNTLYNNTSSGYAGNDDCGQMSAWYVFSAMGFYPVNPADGRYIIGSPLLDECTLKLAGNKEFRIRTIRKSPEDIYIQSVTLNGKKHKDFFITHQDIMNGGTMVFKMGKKPSGWGK 6f90 A 2.40 BS02 MVL A 1 T91 G92 W198 S350 W352 D353 W390 C399 M400 E535 N582 N594 E595 D637 T72 G73 W179 S331 W333 D334 W371 C380 M381 E516 N561 N573 E574 D616 AGEITKYVNPFIGTGAIDGGLSGNNYPGATSPFGMIQLSPDTSEAPNWGDASGYDYNRNTIFGFSHTRLSGTGASDLIDITLMPTSSGRTSSAFTHDEEKARPGYYQVMLKDENINAELTTTQRNGIHRYQYPAGKDAEIILDMDHSADKGSWGRRIINSQIRILNDHAVEGYRIITGWAKLRKIYFYMEFSSPILTSTLRDGGRVHENTAVINGTNLHGCFRFGQLNGKPLTCKVALSSVSMENARQNMEQEAPHWDFDRYVAAADADWEKQLGKIEVKGTEVQKEIFYTALYHTMIQPNTMSDVNGEYMAADYTTRKVANNETHYTTFSLWDTFRASHPLYTLLEPERVTDFVKSMIRQYEYYGYLPIWQLWGQDNYCMIGNHSIPVITDAILKGIPGIDMEKAYEAVYNSSVTSHPNSPFEVWEKYGFMPENIQTQSVSITLEQAFDDWCVAQLAAKLNKDADYQRFHKRSEYYRNLFHPKTKFFQSKNDKGEWIEPFDPYQYGGNGGHPFTEGNAWQYFWYVPHNIQALMELTGGTKAFEQKLDTFFTSTYKSMNHNASGFVGQYAHGNEPSHHVAYLYNFAGQPWKTQKYVSHILNTLYNNTSSGYAGNDDCGQMSAWYVFSAMGFYPVNPADGRYIIGSPLLDECTLKLAGNKEFRIRTIRKSPEDIYIQSVTLNGKKHKDFFITHQDIMNGGTMVFKMGKKPSGWGK 6f90 C 2.40 BS01 CA C 1 D353 N594 E595 D637 D325 N554 E555 D597 EITKYVNPFIGTGGNNYPGATSPFGMIQLSPDTSEAPNWGDASGYDYNRNTIFGFSHTRLSGTGASDLIDITLMPTSSGRTSSAFTHDEEKARPGYYQVMLKDENINAELTTTQRNGIHRYQYPAGKDAEIILDMDHSADKGSWGRRIINSQIRILNDHAVEGYRIITGWAKLRKIYFYMEFSSPILTSTLRDGGRVHENTAVINGTNLHGCFRFGQLNGKPLTCKVALSSVSMENARQNMEQEAPHWDFDRYVAAADADWEKQLGKIEVKGTEVQKEIFYTALYHTMIQPNTMSDVNGEYMAADYTTRKVANNETHYTTFSLWDTFRASHPLYTLLEPERVTDFVKSMIRQYEYYGYLPIWQLWGQDNYCMIGNHSIPVITDAILKGIPGIDMEKAYEAVYNSSVTSHPNSPFEVWEKYGFMPENIQTQSVSITLEQAFDDWCVAQLAAKLNKDADYQRFHKRSEYYRNLFHPKTKFFQSKNDKGEWIEPFDPYQYGGNGGHPFTEGNAWQYFWYVPHNIQALMELTGGTKAFEQKLDTFFTSGFVGQYAHGNEPSHHVAYLYNFAGQPWKTQKYVSHILNTLYNNTSSGYAGNDDCGQMSAWYVFSAMGFYPVNPADGRYIIGSPLLDECTLKLAGNKEFRIRTIRKSPEDIYIQSVTLNGKKHKDFFITHQDIMNGGTMVFKMGKKPSG 6f90 C 2.40 BS02 MVL C 1 T91 G92 W198 W352 D353 W390 C399 M400 E535 N594 E595 D637 T63 G64 W170 W324 D325 W362 C371 M372 E507 N554 E555 D597 EITKYVNPFIGTGGNNYPGATSPFGMIQLSPDTSEAPNWGDASGYDYNRNTIFGFSHTRLSGTGASDLIDITLMPTSSGRTSSAFTHDEEKARPGYYQVMLKDENINAELTTTQRNGIHRYQYPAGKDAEIILDMDHSADKGSWGRRIINSQIRILNDHAVEGYRIITGWAKLRKIYFYMEFSSPILTSTLRDGGRVHENTAVINGTNLHGCFRFGQLNGKPLTCKVALSSVSMENARQNMEQEAPHWDFDRYVAAADADWEKQLGKIEVKGTEVQKEIFYTALYHTMIQPNTMSDVNGEYMAADYTTRKVANNETHYTTFSLWDTFRASHPLYTLLEPERVTDFVKSMIRQYEYYGYLPIWQLWGQDNYCMIGNHSIPVITDAILKGIPGIDMEKAYEAVYNSSVTSHPNSPFEVWEKYGFMPENIQTQSVSITLEQAFDDWCVAQLAAKLNKDADYQRFHKRSEYYRNLFHPKTKFFQSKNDKGEWIEPFDPYQYGGNGGHPFTEGNAWQYFWYVPHNIQALMELTGGTKAFEQKLDTFFTSGFVGQYAHGNEPSHHVAYLYNFAGQPWKTQKYVSHILNTLYNNTSSGYAGNDDCGQMSAWYVFSAMGFYPVNPADGRYIIGSPLLDECTLKLAGNKEFRIRTIRKSPEDIYIQSVTLNGKKHKDFFITHQDIMNGGTMVFKMGKKPSG 6f91 A 1.80 BS01 CA A 1 G589 E591 D633 G571 E573 D615 MAQTEKLTDYVNPFVGTDGYGNVYPGAQIPFGGIQISPDTDSRFYDAASGYKYNHLTLMGFSLTHLSGTGIPDLGDFLFIPGTGEMKLEPGTHEDPDQGYRSRYSHDKEWASPNYYAVELADYGVKAEMTSGVRSGMFRFTYPESDNAFIMIDMNHTLWQSCEWSNLRMINDSTITGYKLVKGWGPERHVYFTATFSKKLTGLRFVQDKKPVIYNTSRFRSSYEAWGKNLMACISFDTKAGEEVTVKTAISAVSTDGARNNMKELDGLTFNELRAKGEALWEKELGKYTLTADRKTKETFYTSAYHAALHPFIFQDSDGQFRGLDKNIEKAEGFTNYTVFSLWDTYRALHPWFNLVQQEVNADIANSMLAHYDKSVEKMLPIWSFYGNETWCMIGYHAVSVLADMIVKEVKGFDYERAYEAMKTTAMNSNYDCLPEYREMGYVPFDKEAESVSKTLEYAYDDYCIAQAAKKLGKEDDYHYFLNRALSYQTLIDPETKYMRGRDSKGDWRTPFTPVAYWGDITEGFTMQYTWYVPQDVQGYINEAGKELFRKRLDELFTVELQGRIGAYWHGNEPCHHVAYLYNYLKEPWKCQKWIRTIVDRFYGNTPDALSGNDDCGQMSAWYMFNCIGFYPVAPSSNIYNIGSPCAEAITVRMSNGKNIEMTADNWSPKNLYVKELYVNGKKYDKSYLTYDDIRDGVKLRFVMSGKPNYKRAVSDEAVPPSISLPEKTMKYKSSIGFLE 6f92 A 1.90 BS01 CA A 1 D344 N590 E591 D633 D340 N586 E587 D629 EKLTDYVNPFVGTDGYGNVYPGAQIPFGGIQISPDTDSRFYDAASGYKYNHLTLMGFSLTHLSGTGIPDLGDFLFIPGTGEMKLEPGTHEDPDQGYRSRYSHDKEWASPNYYAVELADYGVKAEMTSGVRSGMFRFTYPESDNAFIMIDMNHTLWQSCEWSNLRMINDSTITGYKLVKGWGPERHVYFTATFSKKLTGLRFVQDKKPVIYNTSRFRSSYEAWGKNLMACISFDTKAGEEVTVKTAISAVSTDGARNNMKELDGLTFNELRAKGEALWEKELGKYTLTADRKTKETFYTSAYHAALHPFIFQDSDGQFRGLDKNIEKAEGFTNYTVFSLWDTYRALHPWFNLVQQEVNADIANSMLAHYDKSVEKMLPIWSFYGNETWCMIGYHAVSVLADMIVKEVKGFDYERAYEAMKTTAMNSNYDCLPEYREMGYVPFDKEAESVSKTLEYAYDDYCIAQAAKKLGKEDDYHYFLNRALSYQTLIDPETKYMRGRDSKGDWRTPFTPVAYQGPGSVHGWGDITEGFTMQYTWYVPQDVQGYINEAGKELFRKRLDELFTVELPDDIPGAHDIQGRIGAYWHGNEPCHHVAYLYNYLKEPWKCQKWIRTIVDRFYGNTPDALSGNDDCGQMSAWYMFNCIGFYPVAPSSNIYNIGSPCAEAITVRMSNGKNIEMTADNWSPKNLYVKELYVNGKKYDKSYLTYDDIRDGVKLRFVMSGKPNYKRAVSDEAVPPSISLPEKTMKYKSSIGFLEHHHHHH 6f92 A 1.90 BS02 MVL A 1 T69 G70 W184 W343 D344 W383 C392 M393 E531 N590 E591 D633 T65 G66 W180 W339 D340 W379 C388 M389 E527 N586 E587 D629 EKLTDYVNPFVGTDGYGNVYPGAQIPFGGIQISPDTDSRFYDAASGYKYNHLTLMGFSLTHLSGTGIPDLGDFLFIPGTGEMKLEPGTHEDPDQGYRSRYSHDKEWASPNYYAVELADYGVKAEMTSGVRSGMFRFTYPESDNAFIMIDMNHTLWQSCEWSNLRMINDSTITGYKLVKGWGPERHVYFTATFSKKLTGLRFVQDKKPVIYNTSRFRSSYEAWGKNLMACISFDTKAGEEVTVKTAISAVSTDGARNNMKELDGLTFNELRAKGEALWEKELGKYTLTADRKTKETFYTSAYHAALHPFIFQDSDGQFRGLDKNIEKAEGFTNYTVFSLWDTYRALHPWFNLVQQEVNADIANSMLAHYDKSVEKMLPIWSFYGNETWCMIGYHAVSVLADMIVKEVKGFDYERAYEAMKTTAMNSNYDCLPEYREMGYVPFDKEAESVSKTLEYAYDDYCIAQAAKKLGKEDDYHYFLNRALSYQTLIDPETKYMRGRDSKGDWRTPFTPVAYQGPGSVHGWGDITEGFTMQYTWYVPQDVQGYINEAGKELFRKRLDELFTVELPDDIPGAHDIQGRIGAYWHGNEPCHHVAYLYNYLKEPWKCQKWIRTIVDRFYGNTPDALSGNDDCGQMSAWYMFNCIGFYPVAPSSNIYNIGSPCAEAITVRMSNGKNIEMTADNWSPKNLYVKELYVNGKKYDKSYLTYDDIRDGVKLRFVMSGKPNYKRAVSDEAVPPSISLPEKTMKYKSSIGFLEHHHHHH 6f92 B 1.90 BS01 CA B 1 N590 E591 D633 N586 E587 D629 EKLTDYVNPFVGTDGYGNVYPGAQIPFGGIQISPDTDSRFYDAASGYKYNHLTLMGFSLTHLSGTGIPDLGDFLFIPGTGEMKLEPGTHEDPDQGYRSRYSHDKEWASPNYYAVELADYGVKAEMTSGVRSGMFRFTYPESDNAFIMIDMNHTLWQSCEWSNLRMINDSTITGYKLVKGWGPERHVYFTATFSKKLTGLRFVQDKKPVIYNTSRFRSSYEAWGKNLMACISFDTKAGEEVTVKTAISAVSTDGARNNMKELDGLTFNELRAKGEALWEKELGKYTLTADRKTKETFYTSAYHAALHPFIFQDSDGQFRGLDKNIEKAEGFTNYTVFSLWDTYRALHPWFNLVQQEVNADIANSMLAHYDKSVEKMLPIWSFYGNETWCMIGYHAVSVLADMIVKEVKGFDYERAYEAMKTTAMNSNYDCLPEYREMGYVPFDKEAESVSKTLEYAYDDYCIAQAAKKLGKEDDYHYFLNRALSYQTLIDPETKYMRGRDSKGDWRTPFTPVAYQGPGSVHGWGDITEGFTMQYTWYVPQDVQGYINEAGKELFRKRLDELFTVELPDDIPGAHDIQGRIGAYWHGNEPCHHVAYLYNYLKEPWKCQKWIRTIVDRFYGNTPDALSGNDDCGQMSAWYMFNCIGFYPVAPSSNIYNIGSPCAEAITVRMSNGKNIEMTADNWSPKNLYVKELYVNGKKYDKSYLTYDDIRDGVKLRFVMSGKPNYKRAVSDEAVPPSISLPEKTMKYKSS 6fi2 A 1.22 BS01 DJB A 1 F253 Y298 I301 R305 F226 Y271 I274 R278 CAAPDEHCPFVASLLAQREGYGAKATGGLGGKFIEVTSDQDAGPGTLRAALAQARKGPAWIRFASDMTIVLKTQLRVPSNTTIDGRGKRVALIDDGLGVYGAKNVILTHLTIDGRLTRLTQAVNVANDSRDVWVDHMDLSRMSDRLLNVKNGSTDVTISWTKFHNSNKVMLLNNITSKNLFQNYERDSIARVTLHHNYFFNTVQRNPRAQFGTFHLFNNLLENWDFYGMSFSLEAKALVEGNIFNNDAQRKCVEPEFYPTVEGINVNYCRYIPIAPARSALDNGDSDRGAYEKRKADHGYTRDFKAFLRLKDNLYLGDAKPVLKDYRPESAPTPSYCYGYEKATPELAEKIRKFAGNTSGDTPLPRTGAGCPGHH 6fi2 A 1.22 BS02 DJB A 2 Q231 Y254 Y295 L308 Q204 Y227 Y268 L281 CAAPDEHCPFVASLLAQREGYGAKATGGLGGKFIEVTSDQDAGPGTLRAALAQARKGPAWIRFASDMTIVLKTQLRVPSNTTIDGRGKRVALIDDGLGVYGAKNVILTHLTIDGRLTRLTQAVNVANDSRDVWVDHMDLSRMSDRLLNVKNGSTDVTISWTKFHNSNKVMLLNNITSKNLFQNYERDSIARVTLHHNYFFNTVQRNPRAQFGTFHLFNNLLENWDFYGMSFSLEAKALVEGNIFNNDAQRKCVEPEFYPTVEGINVNYCRYIPIAPARSALDNGDSDRGAYEKRKADHGYTRDFKAFLRLKDNLYLGDAKPVLKDYRPESAPTPSYCYGYEKATPELAEKIRKFAGNTSGDTPLPRTGAGCPGHH 6fi2 A 1.22 BS03 DJE A 1 K195 R232 R235 K168 R205 R208 CAAPDEHCPFVASLLAQREGYGAKATGGLGGKFIEVTSDQDAGPGTLRAALAQARKGPAWIRFASDMTIVLKTQLRVPSNTTIDGRGKRVALIDDGLGVYGAKNVILTHLTIDGRLTRLTQAVNVANDSRDVWVDHMDLSRMSDRLLNVKNGSTDVTISWTKFHNSNKVMLLNNITSKNLFQNYERDSIARVTLHHNYFFNTVQRNPRAQFGTFHLFNNLLENWDFYGMSFSLEAKALVEGNIFNNDAQRKCVEPEFYPTVEGINVNYCRYIPIAPARSALDNGDSDRGAYEKRKADHGYTRDFKAFLRLKDNLYLGDAKPVLKDYRPESAPTPSYCYGYEKATPELAEKIRKFAGNTSGDTPLPRTGAGCPGHH 6foq A 1.39 BS01 FAD A 1 W37 V73 R74 G75 G76 G77 H78 S79 M80 S84 L94 G113 G134 V135 V136 T139 G140 G142 G143 L144 L146 G149 F150 G196 G199 V200 V201 Y416 N418 F419 L455 N456 W33 V69 R70 G71 G72 G73 H74 S75 M76 S80 L90 G109 G130 V131 V132 T135 G136 G138 G139 L140 L142 G145 F146 G192 G195 V196 V197 Y412 N414 F415 L451 N452 29686059 QLDPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRPALIARCTSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSRRLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLSRKYGLSIDNLTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAFEFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYLRLAPPLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKPHGLTKATLPYRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTVLEHAADIASPFTQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWAREGYRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFRLNQNIPPS 6foq A 1.39 BS02 OXY A 1 L117 G134 V135 V136 T139 L113 G130 V131 V132 T135 29686059 QLDPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRPALIARCTSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSRRLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLSRKYGLSIDNLTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAFEFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYLRLAPPLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKPHGLTKATLPYRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTVLEHAADIASPFTQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWAREGYRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFRLNQNIPPS 6foq A 1.39 BS03 OXY A 2 W37 H138 P319 W33 H134 P315 29686059 QLDPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRPALIARCTSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSRRLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLSRKYGLSIDNLTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAFEFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYLRLAPPLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKPHGLTKATLPYRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTVLEHAADIASPFTQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWAREGYRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFRLNQNIPPS 6foq B 1.39 BS03 OXY B 2 W37 H138 W33 H134 29686059 QLDPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRPALIARCTSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSRRLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLSRKYGLSIDNLTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAFEFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYLRLAPPLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKPHGLTKATLPYRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTVLEHAADIASPFTQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWAREGYRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFRLNQNIPPS 6foq D 1.39 BS02 OXY D 1 L117 G134 V135 V136 T139 L144 L113 G130 V131 V132 T135 L140 29686059 QLDPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRPALIARCTSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSRRLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLSRKYGLSIDNLTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAFEFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYLRLAPPLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKPHGLTKATLPYRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTVLEHAADIASPFTQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWAREGYRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFRLNQNIPPS 6fp3 D 1.98 BS02 OXY D 1 G134 V135 V136 T139 G130 V131 V132 T135 29686059 QLDPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRPALIARCTSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSRRLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLSRKYGLSIDNLTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAFEFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYLRLAPPLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKPHGLTKATLPYRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTVLEHAADIASPFTQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWAREGYRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFRLNQNIPPS 6fsm A 1.39 BS06 VAL A 1 N112 A113 L133 V139 H142 E143 L202 R203 H231 N112 A113 L133 V139 H142 E143 L202 R203 H231 3.4.24.27 ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGDGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSEMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK 6fy8 A 3.00 BS02 BR A 1 L70 C86 D87 L64 C80 D81 29686059 DPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRPALIARCTSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSRRLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLSRKYGLSIDNLTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAFEFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYLRLAPPLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKPHGLTKATLPYRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTVLEHAADIASPFTQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWAREGYRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFRLNQNIPP 6fyf A 2.20 BS01 FAD A 1 W37 V73 G75 G76 G77 H78 S79 M80 H83 S84 L94 G113 G134 M135 V136 T139 G140 G142 G143 L144 L146 F150 G196 G199 V200 V201 Y416 N418 L455 N456 W32 V68 G70 G71 G72 H73 S74 M75 H78 S79 L89 G108 G129 M130 V131 T134 G135 G137 G138 L139 L141 F145 G191 G194 V195 V196 Y411 N413 L450 N451 29686059 LDPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRPALIARCTSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSRRLRRARAQGGCLLGAFDTATQAHMLATPAGMVSHTGLGGLVLGGGFGWLSRKYGLSIDNLTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAFEFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYLRLAPPLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKPHGLTKATLPYRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTVLEHAADIASPFTQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWAREGYRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFRLNQNIPP 6g1k A 3.60 BS01 Y01 A 1 Y315 T370 L495 F496 A498 Y257 T308 L431 F432 A434 IPLRIVRAESELSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHQFSDFTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPHVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLLDQTRSSRELELILNFRNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFICHTASYLTFLFLLLLASQHIVNPDRQGPKPTTVEWMILPWVLGFIWTEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTWEMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFETLPPPFNIIAENVRLNHQYQEVLRNLVKRYVAAMIRDAKTETEENFKELKQDISSFRYEVIGMM 6g1k A 3.60 BS02 44E A 1 L527 Q569 F572 W573 L463 Q505 F508 W509 IPLRIVRAESELSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHQFSDFTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPHVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLLDQTRSSRELELILNFRNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFICHTASYLTFLFLLLLASQHIVNPDRQGPKPTTVEWMILPWVLGFIWTEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTWEMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFETLPPPFNIIAENVRLNHQYQEVLRNLVKRYVAAMIRDAKTETEENFKELKQDISSFRYEVIGMM 6g1k A 3.60 BS03 44E C 1 F595 A598 T599 T603 I607 F531 A534 T535 T539 I543 IPLRIVRAESELSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHQFSDFTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPHVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLLDQTRSSRELELILNFRNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFICHTASYLTFLFLLLLASQHIVNPDRQGPKPTTVEWMILPWVLGFIWTEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTWEMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFETLPPPFNIIAENVRLNHQYQEVLRNLVKRYVAAMIRDAKTETEENFKELKQDISSFRYEVIGMM 6ge9 A 2.26 BS01 MG A 1 S392 D417 S388 D413 2.7.7.23,2.3.1.157 GDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIAKLAPQRLIVVLGHDHQRIAPLVGELADTLGRTIDVALQDRPLGTGHAVLCGLSALPDDYAGNVVVTSGDTPLLDADTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHEVMAIVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQTVHASHVDDSALVAGVNNRVQLAELASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIGRDTVIHPGTQLLGRTQIGGRCVVGPDTTLTDVAVGDGASVVRTHGSSSSIGDGAAVGPFTYLRPGTALGADGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYDGTSKRRTTVGSHVRTGSDTMFVAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIENWVQRKRPGSPAAQASKRASE