2ndo A BS01 SFQ A 1 H32 Q35 F36 L40 P163 T168 M171 F174 H32 Q35 F36 L40 P163 T168 M171 F174 27778134 AQYEDGKQYTTLEKPVAGAPQVLEFFSFFCPHCYQFEEVLHISDNVKKKLPEGVKMTKYHVNFMGGDLGKDLTQAWAVAMALGVEDKVTVPLFEGVQKTQTIRSASDIRDVFINAGIKGEEYDAAWNSFVVKSLVAQQEKAAADVQLRGVPAMFVNGKYQLNPQGMDTSNMDVFVQQYADTVKYLSEKK 5b2u A 1.90 BS01 HEM A 1 K69 L86 F87 W96 I153 F261 A264 T268 T269 T327 F328 F331 P392 F393 G394 R398 A399 C400 I401 G402 A406 K67 L84 F85 W94 I151 F259 A262 T266 T267 T325 F326 F329 P390 F391 G392 R396 A397 C398 I399 G400 A404 1.14.14.1,1.6.2.4 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTFPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 5b2u A 1.90 BS02 W06 A 1 L20 V26 L29 F42 A44 R47 T49 Y51 S72 Q73 A74 L188 F328 A330 M354 L437 L18 V24 L27 F40 A42 R45 T47 Y49 S70 Q71 A72 L186 F326 A328 M352 L435 1.14.14.1,1.6.2.4 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTFPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 5b2u B 1.90 BS02 W06 B 1 L20 P25 V26 L29 F42 A44 R47 T49 Y51 S72 Q73 A74 M185 L188 F328 A330 L437 L18 P23 V24 L27 F40 A42 R45 T47 Y49 S70 Q71 A72 M183 L186 F326 A328 L435 1.14.14.1,1.6.2.4 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTFPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 5b2v A 2.30 BS01 HEM A 1 K69 L86 F87 W96 F107 I153 A264 G265 T268 T269 L272 T327 A328 F331 P392 F393 G394 R398 A399 C400 I401 G402 A406 K67 L84 F85 W94 F105 I151 A262 G263 T266 T267 L270 T325 A326 F329 P390 F391 G392 R396 A397 C398 I399 G400 A404 1.14.14.1,1.6.2.4 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 5b2v A 2.30 BS02 W06 A 1 L20 V26 A44 R47 Y51 S72 Q73 A74 L188 P329 A330 M354 L18 V24 A42 R45 Y49 S70 Q71 A72 L186 P327 A328 M352 1.14.14.1,1.6.2.4 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 5b2v B 2.30 BS02 W06 B 1 L20 P25 V26 A44 R47 T49 Y51 S72 Q73 A74 M185 L188 A330 M354 L437 L18 P23 V24 A42 R45 T47 Y49 S70 Q71 A72 M183 L186 A328 M352 L435 1.14.14.1,1.6.2.4 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 5b2w A 1.65 BS02 W1Z A 1 L20 V26 R47 Y51 S72 Q73 A74 L75 V78 F87 L188 I263 A264 A328 P329 A330 M354 L437 T438 L17 V23 R44 Y48 S69 Q70 A71 L72 V75 F84 L185 I260 A261 A325 P326 A327 M351 L434 T435 1.14.14.1,1.6.2.4 EMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 5b2w B 1.65 BS02 W1Z B 1 L17 L20 V26 F42 A44 R47 T49 Y51 S72 Q73 A74 L75 F87 L188 I263 A264 A328 P329 A330 M354 L437 T438 L14 L17 V23 F39 A41 R44 T46 Y48 S69 Q70 A71 L72 F84 L185 I260 A261 A325 P326 A327 M351 L434 T435 1.14.14.1,1.6.2.4 EMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 5b2x A 1.90 BS02 W0T A 1 L20 P25 V26 L29 F42 A44 T49 Y51 S72 Q73 A74 M185 F328 P329 A330 L437 L18 P23 V24 L27 F40 A42 T47 Y49 S70 Q71 A72 M183 F326 P327 A328 L435 1.14.14.1,1.6.2.4 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTFPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 5b2x B 1.90 BS01 HEM B 1 K69 L86 F87 W96 I153 A264 T268 T269 L272 T327 F328 F331 P392 F393 G394 R398 A399 C400 I401 G402 A406 K67 L84 F85 W94 I151 A262 T266 T267 L270 T325 F326 F329 P390 F391 G392 R396 A397 C398 I399 G400 A404 1.14.14.1,1.6.2.4 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTFPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 5b2y A 2.01 BS02 W10 A 1 L20 V26 F42 R47 T49 Y51 S72 Q73 A74 L75 F87 A328 A330 M354 L437 T438 L17 V23 F39 R44 T46 Y48 S69 Q70 A71 L72 F84 A325 A327 M351 L434 T435 1.14.14.1,1.6.2.4 EMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 5b2y B 2.01 BS02 W10 B 1 L17 L20 V26 A44 R47 T49 Y51 S72 Q73 A74 L75 F87 I263 A328 P329 A330 M354 L437 T438 L14 L17 V23 A41 R44 T46 Y48 S69 Q70 A71 L72 F84 I260 A325 P326 A327 M351 L434 T435 1.14.14.1,1.6.2.4 EMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 5e69 B 1.85 BS01 NUC C 1 S440 R447 R470 K471 R477 S23 R30 R53 K54 R60 PKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEA 5e6b A 2.25 BS02 NUC D 1 S440 V443 F444 R447 R470 K471 P474 R477 S24 V27 F28 R31 R54 K55 P58 R61 PPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEA 5e6c B 2.20 BS01 NUC C 1 S440 R470 R477 S22 R52 R59 KLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEA 5e6d A 2.40 BS02 NUC D 1 V443 R447 R470 K471 R477 V26 R30 R53 K54 R60 PKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEA 5e6d B 2.40 BS01 NUC C 1 S440 R470 S22 R52 KLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEA 5ef6 A 3.00 BS01 NUC C 1 R217 K218 R220 I221 P222 Y223 R258 Q259 I262 N266 K270 R1 K2 R4 I5 P6 Y7 R42 Q43 I46 N50 K54 RKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAK 5ef6 A 3.00 BS02 NUC F 1 R217 R220 P222 F240 K243 R246 T261 Q265 R268 V269 R1 R4 P6 F24 K27 R30 T45 Q49 R52 V53 RKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAK 5ef6 B 3.00 BS01 NUC D 1 R220 Y223 Q259 I262 N266 K270 R4 Y7 Q43 I46 N50 K54 RKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAK 5ef6 B 3.00 BS02 NUC E 1 R220 P222 F240 K243 R246 T261 Q265 R268 V269 K272 R4 P6 F24 K27 R30 T45 Q49 R52 V53 K56 RKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAK 5ef6 G 3.00 BS02 NUC I 1 R217 R220 F240 K243 R246 T261 Q265 R268 V269 R1 R4 F24 K27 R30 T45 Q49 R52 V53 RKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKV 5ef6 J 3.00 BS02 NUC L 1 R220 P222 F240 K243 R246 T261 Q265 R268 V269 R4 P6 F24 K27 R30 T45 Q49 R52 V53 RKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKV 5f61 A 1.45 BS01 5W0 A 1 W81 P82 F83 Q85 P86 V87 D88 K91 L92 L94 N140 I146 W40 P41 F42 Q44 P45 V46 D47 K50 L51 L53 N99 I105 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 5f63 A 1.45 BS01 5W2 A 1 W81 P82 F83 V87 L92 N93 L94 N140 D145 I146 M149 W40 P41 F42 V46 L51 N52 L53 N99 D104 I105 M108 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 5fdn A 2.20 BS01 ASP A 1 R644 Q676 M828 K832 L884 R887 R891 Q965 N966 R625 Q657 M797 K801 L853 R856 R860 Q911 N912 4.1.1.31 QLRQLVPAKVSEDDKLVEYDALLLDRFLDILQDLHGEDLRETVQELYELSAEYEGKREPSKLEELGSVLTSLDPGDSIVISKAFSHMLNLANLAEEVQIAHRRRIKKLKKGDFVDESSATTESDIEETFKRLVSDLGKSPEEIFDALKNQTVDLVLTAHPTQSVRRSLLQKHGRIRDCLAQLYAKDITPDDKQELDESLQREIQAAFRTDEIRRTPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGIDERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMAANLYYNQIENLMFELSMWRCTDEFRVRADELHRNAKHYIEFWKTIPPTEPYRVILGDVRDKLYHTRERSRQLLSNGISDIPEEATFTNVEQFLEPLELCYRSLCSCGDSPIADGSLLDFLRQVSTFGLSLVRLDIRQESERHTDVLDAITKHLDIGSSYRDWSEEGRQEWLLAELSGKRPLFGPDLPKTEEISDVLDTFKVISELPSDCFGAYIISMATSPSDVLAVELLQRECHVKNPLRVVPLFEKLADLEAAPAAVARLFSIDWYKNRINGKQEVMIGYSDSGKDAGRLSAAWELYKAQEELVKVAKKYGVKLTMFHGRGGTVGRGGGPTHLAILSQPPDTVNGSLRVTVQGEVIEQSFGEAHLCFRTLQRFTAATLEHGMNPPISPKPEWRALLDEMAVVATEEYRSVVFQEPRFVEYFRLATPELEYGRMGGIESLRAIPWIFAWTQTRFHLPVWLGFGAAFRYAIKKDVRNLHMLQDMYKQWPFFRVTIDLIEMVFAKGDPGIAALYDKLLVSEDLWAFGEKLRANFDETKNLVLQTAGHKDLLEGDPYLKQRLRLRDSYITTLNVCQAYTLKRIRDANYNVTLRPHISKGLEDTLILTMKGIAAGLQNTG 5fdn A 2.20 BS02 FLC A 1 I113 R116 S132 A133 T134 G646 G647 D881 Y883 R887 I99 R102 S118 A119 T120 G627 G628 D850 Y852 R856 4.1.1.31 QLRQLVPAKVSEDDKLVEYDALLLDRFLDILQDLHGEDLRETVQELYELSAEYEGKREPSKLEELGSVLTSLDPGDSIVISKAFSHMLNLANLAEEVQIAHRRRIKKLKKGDFVDESSATTESDIEETFKRLVSDLGKSPEEIFDALKNQTVDLVLTAHPTQSVRRSLLQKHGRIRDCLAQLYAKDITPDDKQELDESLQREIQAAFRTDEIRRTPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGIDERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMAANLYYNQIENLMFELSMWRCTDEFRVRADELHRNAKHYIEFWKTIPPTEPYRVILGDVRDKLYHTRERSRQLLSNGISDIPEEATFTNVEQFLEPLELCYRSLCSCGDSPIADGSLLDFLRQVSTFGLSLVRLDIRQESERHTDVLDAITKHLDIGSSYRDWSEEGRQEWLLAELSGKRPLFGPDLPKTEEISDVLDTFKVISELPSDCFGAYIISMATSPSDVLAVELLQRECHVKNPLRVVPLFEKLADLEAAPAAVARLFSIDWYKNRINGKQEVMIGYSDSGKDAGRLSAAWELYKAQEELVKVAKKYGVKLTMFHGRGGTVGRGGGPTHLAILSQPPDTVNGSLRVTVQGEVIEQSFGEAHLCFRTLQRFTAATLEHGMNPPISPKPEWRALLDEMAVVATEEYRSVVFQEPRFVEYFRLATPELEYGRMGGIESLRAIPWIFAWTQTRFHLPVWLGFGAAFRYAIKKDVRNLHMLQDMYKQWPFFRVTIDLIEMVFAKGDPGIAALYDKLLVSEDLWAFGEKLRANFDETKNLVLQTAGHKDLLEGDPYLKQRLRLRDSYITTLNVCQAYTLKRIRDANYNVTLRPHISKGLEDTLILTMKGIAAGLQNTG 5g5s A 2.29 BS01 MG A 1 A289 L292 I295 N297 A272 L275 I278 N280 FTMVLNKVTYKINAYKIKEEFIPKEVHFYRIKSFVNEAFNFYRFVNFYGGMIINKKDKSFVLPYKVDNIPIDIEYIKSLKLEYVKPEIAEKLVRGYLKSVHKIEPELSRIIKENIKVESYCEYEVKKHDGDYYLILNFRHTASITKHLWDFVNRDKALLEEYVGKKIIFKPNPKVRYTISLVDAPNPQKIEEIMSHIIKYYKWSEDMVKSTFGEIDYNQPIMYCEEILEPFAPQFCNLVFYMDELDSYILKELQSYWRLSNENKGKIINEIAKKLRFIDNTPKELEFMKFNNTPLLVKDVNKNPTKIYSTNTLFTWIYNQNAKIYLPYDVPEIIRNKNLLTYILIDEEIKDELKAIKDKVNKMFRNYNKIANKTELPKFNYANRWKYFSTDDIRGIIKEIKSEFNDEICFALIIGKEKYKDNDYYEILKKQLFDLKIISQNILWENWRKDDKGYMTNNLLIQIMGKLGIKYFILDSKTPYDYIMGLDTGLNHRVGGCTVVYDSEGKIRRIQPIETPAPGERLHLPYVIEYLENKANIDMENKNILFLRDGFIQNSERNDLKEISKELNSNIEVISIRKNNKYKVFTSDYRIGSVFGNDGIFLPHKTPFGSNPVKLSTWLRFNCGNEEGLKINESIMQLLYDLTKMNYSALYGEGRYLRIPAPIHYADKFVKALGKNWKIDEELLKHGFLYFI 5g5t A 2.85 BS01 NUC D 1 F45 K107 H157 F186 N189 K191 Y194 E209 I210 H213 Y217 Y218 E243 E246 P247 F248 S456 Q457 N458 I459 L460 M472 Q479 H625 T627 G630 S631 N632 S669 A670 L678 R679 F36 K90 H140 F169 N172 K174 Y177 E192 I193 H196 Y200 Y201 E226 E229 P230 F231 S427 Q428 N429 I430 L431 M443 Q450 H588 T590 G593 S594 N595 S632 A633 L635 R636 MVLNKVTYKINAYKIKEEFIPKEVHFYRIKSRFVNFYGGMIINKKDKSFVLPYKVDNKVLKPIDIEYIKSLKLEYVKPEIAEKLVRGYLKSVHKIEPELSRIIKNIRKHKVVENIKVESYCEYEVKKHDGDYYLILNFRHTASITKHLWDFVNRDKALLEEYVGKKIIFKPNPKVRYTISLVDAPNPQKIEEIMSHIIKYYKWSEDMVKSTFGEIDYNQPIMYCEEILEPFAPQFCNLVFYMDELDSYILKELQSYWRLSNENKGKIINEIAKKLRFIDNTPKELEFMKFNNTPLLVKDVNKNPTKIYSTNTLFTWIKIYLPYDVPEIIRNKNLLTYILIDEEIKDELKAIKDKVNKMFRNYNKIANKTELPKFNYANRWKYFSTDDIRGIIKEIKSEFNDEICFALIIGKEYEILKKQLFDLKIISQNILWENWRKDDKGYMTNNLLIQIMGKLGIKYFILDSKTPYDYIMGLDTGNHRVGGCTVVYDSEGKIRRIQPIETPERLHLPYVIEYLENKANIDMENKNILFLRDGFIQNSERNDLKEISKELNSNIEVISIRKNNKYKVFTSDYRIGSVFGNDGIFLPHKTPFGSNPVKLSTWLRFNCGNEEGLKINESIMQLLYDLTKMNYSAYLRIPAPIHYADKFVKALGKNWKIDEELLKHGFLYFI 5g5t A 2.85 BS02 MG A 1 Q457 Q479 K483 Q428 Q450 K454 MVLNKVTYKINAYKIKEEFIPKEVHFYRIKSRFVNFYGGMIINKKDKSFVLPYKVDNKVLKPIDIEYIKSLKLEYVKPEIAEKLVRGYLKSVHKIEPELSRIIKNIRKHKVVENIKVESYCEYEVKKHDGDYYLILNFRHTASITKHLWDFVNRDKALLEEYVGKKIIFKPNPKVRYTISLVDAPNPQKIEEIMSHIIKYYKWSEDMVKSTFGEIDYNQPIMYCEEILEPFAPQFCNLVFYMDELDSYILKELQSYWRLSNENKGKIINEIAKKLRFIDNTPKELEFMKFNNTPLLVKDVNKNPTKIYSTNTLFTWIKIYLPYDVPEIIRNKNLLTYILIDEEIKDELKAIKDKVNKMFRNYNKIANKTELPKFNYANRWKYFSTDDIRGIIKEIKSEFNDEICFALIIGKEYEILKKQLFDLKIISQNILWENWRKDDKGYMTNNLLIQIMGKLGIKYFILDSKTPYDYIMGLDTGNHRVGGCTVVYDSEGKIRRIQPIETPERLHLPYVIEYLENKANIDMENKNILFLRDGFIQNSERNDLKEISKELNSNIEVISIRKNNKYKVFTSDYRIGSVFGNDGIFLPHKTPFGSNPVKLSTWLRFNCGNEEGLKINESIMQLLYDLTKMNYSAYLRIPAPIHYADKFVKALGKNWKIDEELLKHGFLYFI 5gkd A 2.19 BS01 CA A 1 N181 E184 E213 E215 N180 E183 E212 E214 ADLLVKTPEAYDQALKKAKPGDDIILANGTWRDFEVLFEAKGNENKPITLRGQTPGKVFLTGQSNLRLAGEHLIVSGLVFKDGYTPTGEVIAFRRNKDVLASHSRVTQVVIDNFSNPEKFEQDSWVMVYGRHNRFDHNHLVGKRNKGVTMAVRLTTESSQQNHHRIDHNYFGPRPILGSNGGETLRIGTSHHSLTDSFTLVENNYFDRCNGEVEIISNKSGKNSIRNNVFFESRGTLTLRHGNGNIVENNVFFGNGVDHTGGIRVINRDQIIRNNYLEGLTGYRFGSGLTVMNGVPNSKINRYHQVDNALIENNTLVNVEHIQFAAGSDKERSAAPINSNMNNNLIVNDQGTDGITAFDDISGIKFKDNLLNQDAKPSINKGFEQADITMQRHDNGLLYPEAKTQQKYGVSTQLEPIGKDEVGVSWYPKVEPDVAFGSGKHIAVSPGDNTLFDAIASAETGDVLVLQAGEYWVSKILSLDKTLTIRAQEKGSAVIFPQRSTLIEINNKGNLTLDGVYVDATNAPDAAGNTLIRTTRLPMQRNYRLAIKNSTFENLDINHSYHFFDAGNRSFADYIEVQDSQFKHITGDLFRLNKETDDLGIYNVEYLTIENSNVSDLQGAIAKVYRGGTDESTFGPHVVMNNNIFNEVGKGKRNKSAASLILHGTQVNKMTTNEFNNSAPIIFELTVGEPKTWVTGNVFEGTPEPVVRDLFPLSGATTTISGNTVL 5gkd A 2.19 BS02 CO3 A 1 E215 R241 R265 Y304 E214 R240 R264 Y303 ADLLVKTPEAYDQALKKAKPGDDIILANGTWRDFEVLFEAKGNENKPITLRGQTPGKVFLTGQSNLRLAGEHLIVSGLVFKDGYTPTGEVIAFRRNKDVLASHSRVTQVVIDNFSNPEKFEQDSWVMVYGRHNRFDHNHLVGKRNKGVTMAVRLTTESSQQNHHRIDHNYFGPRPILGSNGGETLRIGTSHHSLTDSFTLVENNYFDRCNGEVEIISNKSGKNSIRNNVFFESRGTLTLRHGNGNIVENNVFFGNGVDHTGGIRVINRDQIIRNNYLEGLTGYRFGSGLTVMNGVPNSKINRYHQVDNALIENNTLVNVEHIQFAAGSDKERSAAPINSNMNNNLIVNDQGTDGITAFDDISGIKFKDNLLNQDAKPSINKGFEQADITMQRHDNGLLYPEAKTQQKYGVSTQLEPIGKDEVGVSWYPKVEPDVAFGSGKHIAVSPGDNTLFDAIASAETGDVLVLQAGEYWVSKILSLDKTLTIRAQEKGSAVIFPQRSTLIEINNKGNLTLDGVYVDATNAPDAAGNTLIRTTRLPMQRNYRLAIKNSTFENLDINHSYHFFDAGNRSFADYIEVQDSQFKHITGDLFRLNKETDDLGIYNVEYLTIENSNVSDLQGAIAKVYRGGTDESTFGPHVVMNNNIFNEVGKGKRNKSAASLILHGTQVNKMTTNEFNNSAPIIFELTVGEPKTWVTGNVFEGTPEPVVRDLFPLSGATTTISGNTVL 5gkq A 2.57 BS01 CA A 1 N181 E184 E213 E215 S633 N180 E183 E212 E214 S632 ADLLVKTPEAYDQALKKAKPGDDIILANGTWRDFEVLFEAKGNENKPITLRGQTPGKVFLTGQSNLRLAGEHLIVSGLVFKDGYTPTGEVIAFRRNKDVLASHSRVTQVVIDNFSNPEKFEQDSWVMVYGRHNRFDHNHLVGKRNKGVTMAVRLTTESSQQNHHRIDHNYFGPRPILGSNGGETLRIGTSHHSLTDSFTLVENNYFDRCNGEVEIISNKSGKNSIRNNVFFESRGTLTLAHGNGNIVENNVFFGNGVDHTGGIRVINRDQIIRNNYLEGLTGYRFGSGLTVMNGVPNSKINRYHQVDNALIENNTLVNVEHIQFAAGSDKERSAAPINSNMNNNLIVNDQGTDGITAFDDISGIKFKDNLLNQDAKPSINKGFEQADITMQRHDNGLLYPEAKTQQKYGVSTQLEPIGKDEVGVSWYPKVEPDVAFGSGKHIAVSPGDNTLFDAIASAETGDVLVLQAGEYWVSKILSLDKTLTIRAQEKGSAVIFPQRSTLIEINNKGNLTLDGVYVDATNAPDAAGNTLIRTTRLPMQRNYRLAIKNSTFENLDINHSYHFFDAGNRSFADYIEVQDSQFKHITGDLFRLNKETDDLGIYNVEYLTIENSNVSDLQGAIAKVYRGGTDESTFGPHVVMNNNIFNEVGKGKRNKSAASLILHGTQVNKMTTNEFNNSAPIIFELTVGEPKTWVTGNVFEGTPEPVVRDLFPLSGATTTISGNTVL 5gkq A 2.57 BS02 BEM A 1 N302 R303 Y304 R333 N301 R302 Y303 R332 ADLLVKTPEAYDQALKKAKPGDDIILANGTWRDFEVLFEAKGNENKPITLRGQTPGKVFLTGQSNLRLAGEHLIVSGLVFKDGYTPTGEVIAFRRNKDVLASHSRVTQVVIDNFSNPEKFEQDSWVMVYGRHNRFDHNHLVGKRNKGVTMAVRLTTESSQQNHHRIDHNYFGPRPILGSNGGETLRIGTSHHSLTDSFTLVENNYFDRCNGEVEIISNKSGKNSIRNNVFFESRGTLTLAHGNGNIVENNVFFGNGVDHTGGIRVINRDQIIRNNYLEGLTGYRFGSGLTVMNGVPNSKINRYHQVDNALIENNTLVNVEHIQFAAGSDKERSAAPINSNMNNNLIVNDQGTDGITAFDDISGIKFKDNLLNQDAKPSINKGFEQADITMQRHDNGLLYPEAKTQQKYGVSTQLEPIGKDEVGVSWYPKVEPDVAFGSGKHIAVSPGDNTLFDAIASAETGDVLVLQAGEYWVSKILSLDKTLTIRAQEKGSAVIFPQRSTLIEINNKGNLTLDGVYVDATNAPDAAGNTLIRTTRLPMQRNYRLAIKNSTFENLDINHSYHFFDAGNRSFADYIEVQDSQFKHITGDLFRLNKETDDLGIYNVEYLTIENSNVSDLQGAIAKVYRGGTDESTFGPHVVMNNNIFNEVGKGKRNKSAASLILHGTQVNKMTTNEFNNSAPIIFELTVGEPKTWVTGNVFEGTPEPVVRDLFPLSGATTTISGNTVL 5gkq A 2.57 BS03 BEM A 2 K220 H242 K219 H241 ADLLVKTPEAYDQALKKAKPGDDIILANGTWRDFEVLFEAKGNENKPITLRGQTPGKVFLTGQSNLRLAGEHLIVSGLVFKDGYTPTGEVIAFRRNKDVLASHSRVTQVVIDNFSNPEKFEQDSWVMVYGRHNRFDHNHLVGKRNKGVTMAVRLTTESSQQNHHRIDHNYFGPRPILGSNGGETLRIGTSHHSLTDSFTLVENNYFDRCNGEVEIISNKSGKNSIRNNVFFESRGTLTLAHGNGNIVENNVFFGNGVDHTGGIRVINRDQIIRNNYLEGLTGYRFGSGLTVMNGVPNSKINRYHQVDNALIENNTLVNVEHIQFAAGSDKERSAAPINSNMNNNLIVNDQGTDGITAFDDISGIKFKDNLLNQDAKPSINKGFEQADITMQRHDNGLLYPEAKTQQKYGVSTQLEPIGKDEVGVSWYPKVEPDVAFGSGKHIAVSPGDNTLFDAIASAETGDVLVLQAGEYWVSKILSLDKTLTIRAQEKGSAVIFPQRSTLIEINNKGNLTLDGVYVDATNAPDAAGNTLIRTTRLPMQRNYRLAIKNSTFENLDINHSYHFFDAGNRSFADYIEVQDSQFKHITGDLFRLNKETDDLGIYNVEYLTIENSNVSDLQGAIAKVYRGGTDESTFGPHVVMNNNIFNEVGKGKRNKSAASLILHGTQVNKMTTNEFNNSAPIIFELTVGEPKTWVTGNVFEGTPEPVVRDLFPLSGATTTISGNTVL 5gkq A 2.57 BS04 BEM A 3 S191 K220 S190 K219 ADLLVKTPEAYDQALKKAKPGDDIILANGTWRDFEVLFEAKGNENKPITLRGQTPGKVFLTGQSNLRLAGEHLIVSGLVFKDGYTPTGEVIAFRRNKDVLASHSRVTQVVIDNFSNPEKFEQDSWVMVYGRHNRFDHNHLVGKRNKGVTMAVRLTTESSQQNHHRIDHNYFGPRPILGSNGGETLRIGTSHHSLTDSFTLVENNYFDRCNGEVEIISNKSGKNSIRNNVFFESRGTLTLAHGNGNIVENNVFFGNGVDHTGGIRVINRDQIIRNNYLEGLTGYRFGSGLTVMNGVPNSKINRYHQVDNALIENNTLVNVEHIQFAAGSDKERSAAPINSNMNNNLIVNDQGTDGITAFDDISGIKFKDNLLNQDAKPSINKGFEQADITMQRHDNGLLYPEAKTQQKYGVSTQLEPIGKDEVGVSWYPKVEPDVAFGSGKHIAVSPGDNTLFDAIASAETGDVLVLQAGEYWVSKILSLDKTLTIRAQEKGSAVIFPQRSTLIEINNKGNLTLDGVYVDATNAPDAAGNTLIRTTRLPMQRNYRLAIKNSTFENLDINHSYHFFDAGNRSFADYIEVQDSQFKHITGDLFRLNKETDDLGIYNVEYLTIENSNVSDLQGAIAKVYRGGTDESTFGPHVVMNNNIFNEVGKGKRNKSAASLILHGTQVNKMTTNEFNNSAPIIFELTVGEPKTWVTGNVFEGTPEPVVRDLFPLSGATTTISGNTVL 5gkq A 2.57 BS05 BEM A 4 Q123 R154 R187 Q122 R153 R186 ADLLVKTPEAYDQALKKAKPGDDIILANGTWRDFEVLFEAKGNENKPITLRGQTPGKVFLTGQSNLRLAGEHLIVSGLVFKDGYTPTGEVIAFRRNKDVLASHSRVTQVVIDNFSNPEKFEQDSWVMVYGRHNRFDHNHLVGKRNKGVTMAVRLTTESSQQNHHRIDHNYFGPRPILGSNGGETLRIGTSHHSLTDSFTLVENNYFDRCNGEVEIISNKSGKNSIRNNVFFESRGTLTLAHGNGNIVENNVFFGNGVDHTGGIRVINRDQIIRNNYLEGLTGYRFGSGLTVMNGVPNSKINRYHQVDNALIENNTLVNVEHIQFAAGSDKERSAAPINSNMNNNLIVNDQGTDGITAFDDISGIKFKDNLLNQDAKPSINKGFEQADITMQRHDNGLLYPEAKTQQKYGVSTQLEPIGKDEVGVSWYPKVEPDVAFGSGKHIAVSPGDNTLFDAIASAETGDVLVLQAGEYWVSKILSLDKTLTIRAQEKGSAVIFPQRSTLIEINNKGNLTLDGVYVDATNAPDAAGNTLIRTTRLPMQRNYRLAIKNSTFENLDINHSYHFFDAGNRSFADYIEVQDSQFKHITGDLFRLNKETDDLGIYNVEYLTIENSNVSDLQGAIAKVYRGGTDESTFGPHVVMNNNIFNEVGKGKRNKSAASLILHGTQVNKMTTNEFNNSAPIIFELTVGEPKTWVTGNVFEGTPEPVVRDLFPLSGATTTISGNTVL 5gkq B 2.57 BS01 CA B 1 N181 G182 E184 E213 S633 N180 G181 E183 E212 S632 ADLLVKTPEAYDQALKKAKPGDDIILANGTWRDFEVLFEAKGNENKPITLRGQTPGKVFLTGQSNLRLAGEHLIVSGLVFKDGYTPTGEVIAFRRNKDVLASHSRVTQVVIDNFSNPEKFEQDSWVMVYGRHNRFDHNHLVGKRNKGVTMAVRLTTESSQQNHHRIDHNYFGPRPILGSNGGETLRIGTSHHSLTDSFTLVENNYFDRCNGEVEIISNKSGKNSIRNNVFFESRGTLTLAHGNGNIVENNVFFGNGVDHTGGIRVINRDQIIRNNYLEGLTGYRFGSGLTVMNGVPNSKINRYHQVDNALIENNTLVNVEHIQFAAGSDKERSAAPINSNMNNNLIVNDQGTDGITAFDDISGIKFKDNLLNQDAKPSINKGFEQADITMQRHDNGLLYPEAKTQQKYGVSTQLEPIGKDEVGVSWYPKVEPDVAFGSGKHIAVSPGDNTLFDAIASAETGDVLVLQAGEYWVSKILSLDKTLTIRAQEKGSAVIFPQRSTLIEINNKGNLTLDGVYVDATNAPDAAGNTLIRTTRLPMQRNYRLAIKNSTFENLDINHSYHFFDAGNRSFADYIEVQDSQFKHITGDLFRLNKETDDLGIYNVEYLTIENSNVSDLQGAIAKVYRGGTDESTFGPHVVMNNNIFNEVGKGKRNKSAASLILHGTQVNKMTTNEFNNSAPIIFELTVGEPKTWVTGNVFEGTPEPVVRDLFPLSGATTTISGNTVL 5gt2 A 2.09 BS01 HEM A 1 D138 F142 V143 D144 G145 T146 E147 Q175 W177 H179 R198 H216 V220 R233 L247 F249 Q262 L263 M266 M278 T282 D135 F139 V140 D141 G142 T143 E144 Q172 W174 H176 R195 H213 V217 R230 L244 F246 Q259 L260 M263 M274 T278 1.11.1.- 28109884 QVQSGILPEHCRAAIWIEANVKGEVDALRAASKTFADKLATFEAKFPDAHLGAVVAFGNNTWRALSGGVGAEELKDFPGYGKGLAPTTQFDVLIHILSLRHDVNFSVAQAAMEAFGDCIEVKEEIHGFRWVEERDLSGFVDGTENPAGEETRREVAVIKDGVDAGGSYVFVQRWEHNLKQLNRMSVHDQEMMIGRTKEANEEIDGDERPETSHLTRVDLKEDGKGLKIVRQSLPYGTASGTHGLYFCAYCARLHNIEQQLLSMFGDTDGKRDAMLRFTKPVTGGYYFAPSLDKLMA 5gyr A 1.60 BS01 HEM A 1 F91 C121 C124 H125 R129 F91 C121 C124 H125 R129 27883268 AGLSPEEQIETRQAGYEFMGWNMGKIKANLEGEYNAAQVEAAANVIAAIANSGMGALYGPGTDKNVGDVKTRVKPEFFQNMEDVGKIAREFVGAANTLAEVAATGEAEAVKTAFGDVGAACKSCHEKYRAK 5gyr A 1.60 BS02 HEM N 1 R12 Q13 Y16 G20 Y58 T71 R72 R12 Q13 Y16 G20 Y58 T71 R72 27883268 AGLSPEEQIETRQAGYEFMGWNMGKIKANLEGEYNAAQVEAAANVIAAIANSGMGALYGPGTDKNVGDVKTRVKPEFFQNMEDVGKIAREFVGAANTLAEVAATGEAEAVKTAFGDVGAACKSCHEKYRAK 5gyr B 1.60 BS01 HEM B 1 R12 Q13 Y16 G20 Y58 T71 R72 F91 V117 C121 C124 H125 R129 R12 Q13 Y16 G20 Y58 T71 R72 F91 V117 C121 C124 H125 R129 27883268 AGLSPEEQIETRQAGYEFMGWNMGKIKANLEGEYNAAQVEAAANVIAAIANSGMGALYGPGTDKNVGDVKTRVKPEFFQNMEDVGKIAREFVGAANTLAEVAATGEAEAVKTAFGDVGAACKSCHEKYRAK 5gyr E 1.60 BS01 HEM E 1 F91 V117 C121 C124 H125 R129 F91 V117 C121 C124 H125 R129 27883268 AGLSPEEQIETRQAGYEFMGWNMGKIKANLEGEYNAAQVEAAANVIAAIANSGMGALYGPGTDKNVGDVKTRVKPEFFQNMEDVGKIAREFVGAANTLAEVAATGEAEAVKTAFGDVGAACKSCHEKYRAK 5gyr E 1.60 BS02 HEM J 1 R12 Q13 Y16 G20 M23 Y58 T71 R72 R12 Q13 Y16 G20 M23 Y58 T71 R72 27883268 AGLSPEEQIETRQAGYEFMGWNMGKIKANLEGEYNAAQVEAAANVIAAIANSGMGALYGPGTDKNVGDVKTRVKPEFFQNMEDVGKIAREFVGAANTLAEVAATGEAEAVKTAFGDVGAACKSCHEKYRAK 5gyr F 1.60 BS01 HEM F 1 R12 Q13 Y16 G20 Y58 T71 R72 V73 F91 C121 C124 H125 R129 R12 Q13 Y16 G20 Y58 T71 R72 V73 F91 C121 C124 H125 R129 27883268 AGLSPEEQIETRQAGYEFMGWNMGKIKANLEGEYNAAQVEAAANVIAAIANSGMGALYGPGTDKNVGDVKTRVKPEFFQNMEDVGKIAREFVGAANTLAEVAATGEAEAVKTAFGDVGAACKSCHEKYRAK 5hif A 1.60 BS01 ZN A 1 D118 H119 D221 H268 D123 H124 D226 H273 3.1.1.35 GTIGSMAAAPQVKTQAPGFYRMMLGDFEVTALSDGTVDLPVDKLLNQPPAKTQSALAKSFLKAPLETSVNAYLVNTGSKLVLVDTGAAGLFGPTLGKLAANLKAAGYQPEQVDEIYITHMHPDHVGGLMANEQAAFPNAVVRADQKDADFWLSQANLDKAPDDEKGFFQGAMASLNPYVKAGKFKPFSGNTDLVPGIKALASHGHTPGHTTYVVESKGQKLVLLGDLIHVAAVQFDDPSVTIQFDSDSKAAAAERKKAFADAAKGGYLIGAAHLSFPGIGHIRADGKGYRFVPVNYSVA 5hif A 1.60 BS02 ZN A 2 H114 H116 H200 D221 H119 H121 H205 D226 3.1.1.35 GTIGSMAAAPQVKTQAPGFYRMMLGDFEVTALSDGTVDLPVDKLLNQPPAKTQSALAKSFLKAPLETSVNAYLVNTGSKLVLVDTGAAGLFGPTLGKLAANLKAAGYQPEQVDEIYITHMHPDHVGGLMANEQAAFPNAVVRADQKDADFWLSQANLDKAPDDEKGFFQGAMASLNPYVKAGKFKPFSGNTDLVPGIKALASHGHTPGHTTYVVESKGQKLVLLGDLIHVAAVQFDDPSVTIQFDSDSKAAAAERKKAFADAAKGGYLIGAAHLSFPGIGHIRADGKGYRFVPVNYSVA 5hif B 1.60 BS03 MG B 1 D280 R285 D285 R290 3.1.1.35 GTIGSMAAAPQVKTQAPGFYRMMLGDFEVTALSDGTVDLPVDKLLNQPPAKTQSALAKSFLKAPLETSVNAYLVNTGSKLVLVDTGAAGLFGPTLGKLAANLKAAGYQPEQVDEIYITHMHPDHVGGLMANEQAAFPNAVVRADQKDADFWLSQANLDKAPDDEKGFFQGAMASLNPYVKAGKFKPFSGNTDLVPGIKALASHGHTPGHTTYVVESKGQKLVLLGDLIHVAAVQFDDPSVTIQFDSDSKAAAAERKKAFADAAKGGYLIGAAHLSFPGIGHIRADGKGYRFVPVNYSVA 5ho4 A 1.85 BS01 NUC B 1 Q19 K22 F24 G26 G27 D49 V51 M53 R62 G63 F64 F66 E92 A96 V97 R99 S102 H108 Q5 K8 F10 G12 G13 D35 V37 M39 R48 G49 F50 F52 E78 A82 V83 R85 S88 H94 REKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEM 5hvu A 2.80 BS01 65R A 1 I82 G85 F87 G88 E89 V90 A103 K105 L107 D117 F120 M153 E154 Y155 M156 A215 D216 G218 I77 G80 F82 G83 E84 V85 A98 K100 L102 D112 F115 M148 E149 Y150 M151 A210 D211 G213 2.7.11.1 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEETFPIPKAFVGNQLPFVGFTYYSNRRY 5hvu B 2.80 BS01 65R B 1 I82 R84 G85 F87 G88 E89 V90 A103 K105 D117 F120 M153 E154 Y155 M156 A215 D216 G218 I78 R80 G81 F83 G84 E85 V86 A99 K101 D113 F116 M149 E150 Y151 M152 A211 D212 G214 2.7.11.1 MSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSN 5hwa A 1.35 BS01 GCS A 1 Q37 D55 R57 F64 G65 L175 N176 K218 Y219 Q37 D55 R57 F64 G65 L175 N176 K218 Y219 3.2.1.132 ASPDDNFSPETLQFLRNNTGLDGEQWNNIMKLINKPQQDDLNWIKYYGYCEDIEDERGYTIGLFGATTGGSRDTHPDGPDLFKAYDAAKGASNPSADGALKRLGINGKMKGSILEIKDSEKVFCGKIKKLQNDAAWRKAMWETFYNVYIRYSVEQARQRGFTSAVTIGSFVDTALNQGATGGSDTLQGLLARSGSSSNEKTFMKNFHAKRTLVVDTNKYNKPPNGKNRVKQWDTLVDMGKMNLKNVDSEIAQVTDWEMK 5hwa A 1.35 BS02 GCS A 2 R57 G65 T67 D73 D77 Y148 L175 N176 Q177 G178 Y219 R57 G65 T67 D73 D77 Y148 L175 N176 Q177 G178 Y219 3.2.1.132 ASPDDNFSPETLQFLRNNTGLDGEQWNNIMKLINKPQQDDLNWIKYYGYCEDIEDERGYTIGLFGATTGGSRDTHPDGPDLFKAYDAAKGASNPSADGALKRLGINGKMKGSILEIKDSEKVFCGKIKKLQNDAAWRKAMWETFYNVYIRYSVEQARQRGFTSAVTIGSFVDTALNQGATGGSDTLQGLLARSGSSSNEKTFMKNFHAKRTLVVDTNKYNKPPNGKNRVKQWDTLVDMGKMNLKNVDSEIAQVTDWEMK 5hwa A 1.35 BS03 GCS A 3 D73 H75 V147 G178 A179 D73 H75 V147 G178 A179 3.2.1.132 ASPDDNFSPETLQFLRNNTGLDGEQWNNIMKLINKPQQDDLNWIKYYGYCEDIEDERGYTIGLFGATTGGSRDTHPDGPDLFKAYDAAKGASNPSADGALKRLGINGKMKGSILEIKDSEKVFCGKIKKLQNDAAWRKAMWETFYNVYIRYSVEQARQRGFTSAVTIGSFVDTALNQGATGGSDTLQGLLARSGSSSNEKTFMKNFHAKRTLVVDTNKYNKPPNGKNRVKQWDTLVDMGKMNLKNVDSEIAQVTDWEMK 5hwa A 1.35 BS04 GCS A 4 H75 T180 G181 H75 T180 G181 3.2.1.132 ASPDDNFSPETLQFLRNNTGLDGEQWNNIMKLINKPQQDDLNWIKYYGYCEDIEDERGYTIGLFGATTGGSRDTHPDGPDLFKAYDAAKGASNPSADGALKRLGINGKMKGSILEIKDSEKVFCGKIKKLQNDAAWRKAMWETFYNVYIRYSVEQARQRGFTSAVTIGSFVDTALNQGATGGSDTLQGLLARSGSSSNEKTFMKNFHAKRTLVVDTNKYNKPPNGKNRVKQWDTLVDMGKMNLKNVDSEIAQVTDWEMK 5hwa A 1.35 BS05 ZN A 1 D52 E54 D52 E54 3.2.1.132 ASPDDNFSPETLQFLRNNTGLDGEQWNNIMKLINKPQQDDLNWIKYYGYCEDIEDERGYTIGLFGATTGGSRDTHPDGPDLFKAYDAAKGASNPSADGALKRLGINGKMKGSILEIKDSEKVFCGKIKKLQNDAAWRKAMWETFYNVYIRYSVEQARQRGFTSAVTIGSFVDTALNQGATGGSDTLQGLLARSGSSSNEKTFMKNFHAKRTLVVDTNKYNKPPNGKNRVKQWDTLVDMGKMNLKNVDSEIAQVTDWEMK 5hwa A 1.35 BS06 ZN A 2 K204 K230 D233 D237 K204 K230 D233 D237 3.2.1.132 ASPDDNFSPETLQFLRNNTGLDGEQWNNIMKLINKPQQDDLNWIKYYGYCEDIEDERGYTIGLFGATTGGSRDTHPDGPDLFKAYDAAKGASNPSADGALKRLGINGKMKGSILEIKDSEKVFCGKIKKLQNDAAWRKAMWETFYNVYIRYSVEQARQRGFTSAVTIGSFVDTALNQGATGGSDTLQGLLARSGSSSNEKTFMKNFHAKRTLVVDTNKYNKPPNGKNRVKQWDTLVDMGKMNLKNVDSEIAQVTDWEMK 5hxd A 2.60 BS01 ZN A 1 H49 E52 H157 D158 H49 E52 H157 D158 27894248 MTVTRPRAERGAFPPGTEHYGRSLLGAPLIWFPAPAASRESGLILAGTHGDENSSVVTLSCALRTLTPSLRRHHVVLCVNPDGCQLGLRANANGVDLNRNFPAANWKEGETVYRWNSAAEERDVVLLTGDKPGSEPETQALCQLIHRIQPAWVVSFHDPLACIEDPRHSELGEWLAQAFELPLVTSVGYETPGSFGSWCADLNLHCITAEFPPISSDEASEKYLFAMANLLRWHPKD 5hxd B 2.60 BS01 ZN B 1 H49 E52 H157 H49 E52 H157 27894248 MTVTRPRAERGAFPPGTEHYGRSLLGAPLIWFPAPAASRESGLILAGTHGDENSSVVTLSCALRTLTPSLRRHHVVLCVNPDGCQLGLRANANGVDLNRNFPAANWKEGETVYRWNSAAEERDVVLLTGDKPGSEPETQALCQLIHRIQPAWVVSFHDPLACIEDPRHSELGEWLAQAFELPLVTYETPGSFGSWCADLNLHCITAEFPPISSDEASEKYLFAMANLLRWHPKD 5i0v A 1.65 BS01 FE A 1 E3 E44 E3 E44 GGEVPIGDPKELNGMEIAAVYLQPIEMEPRGIDLAASLADIHLEADIHALKNNPNGFPEGFWMPYLTIAYELKNTDTGAIKRGTLMPMVADDGPHYGANIAMEKDKKGGFGVGNYELTFYISNPEKQGFGRHVDEETGVGKWFEPFKVDYKFKYTGTPK 5i0x A 1.50 BS01 CU A 1 H44 E46 H97 H44 E46 H97 MGFKEYPAGEPVTMNEMELAAVYLQPIDMEPRGMGLPAAKADVHLEADIHAVEGNKNGFGAGEWIPYLTISYTLVNNDTGEKQEGTFMPIVASDGPHYGANIKMMGVGNYKVTYHIEPPSKAGMHRHTDSETGVGRWWKPFDVSYEFKYVGLN 5i0x B 1.50 BS01 CU A 2 H44 E46 I90 H97 H42 E44 I88 H95 FKEYPAGEPVTMNEMELAAVYLQPIDMEPRGMGLPAAKADVHLEADIHAVEGNKNGFGAGEWIPYLTISYTLVNNDTGEKQEGTFMPIVASDGPHYGANIKMMGVGNYKVTYHIEPPSKAGMHRHTDSETGVGRWWKPFDVSYEFKYVGLNSSGLVPR 5i0x B 1.50 BS02 CU B 1 H115 D142 H113 D140 FKEYPAGEPVTMNEMELAAVYLQPIDMEPRGMGLPAAKADVHLEADIHAVEGNKNGFGAGEWIPYLTISYTLVNNDTGEKQEGTFMPIVASDGPHYGANIKMMGVGNYKVTYHIEPPSKAGMHRHTDSETGVGRWWKPFDVSYEFKYVGLNSSGLVPR 5i0y A 1.40 BS01 CU A 1 H44 M90 H97 H42 M88 H95 FKEYPAGEPVTMNEMELAAVYLQPIDMEPRGMGLPAAKADVHLQADIHAVEGNKNGFGAGEWIPYLTISYTLVNNDTGEKQEGTFMPMVASDGPHYGANIKMMGVGNYKVTYHIEPPSKAGMHRHTDSETGVGRWWKPFDVSYEFKYVGL 5i1y B 1.95 BS01 CO A 1 T14 H16 H31 T8 H10 H25 HMFTGLNTPHGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVLPFTGLNTPSGVAVDSAGTVYVTDHGNNRVVKLAAGSNTQTVL 5iiy A 1.89 BS03 SIA A 1 R342 Q344 F345 T346 R347 Y368 R94 Q96 F97 T98 R99 Y120 27685666 RRATDTTPPTITVPSDIIAYRGEEFEFYFEITDDSGQVKNIELSTFGKPLGLNWLEYSEDNFNVPGNATSDNPLRVRVHGTVPLNEPIPADKNRAQFTRTIRAWDAAGNVSSNITFVIKYRAQTDKYNPADPTITYVDRLSSLSPSEKNAVEAAVRAANPQIPAAARITVSANGTVTITYPDSSTDTITANRVVKDLASS 5ij1 A 1.80 BS02 GAL A 1 F294 T346 F46 T98 27685666 RRATDTTPPTITVPSDIIAYRGEEFEFYFEITDDSGQVKNIELSTFGKPLGLNWLEYSEDNFNVPGNATSDNPLRVRVHGTVPLNEPIPADKNRAQFTRTIRAWDAAGNVSSNITFVIKYRAQTDKYNPADPTITYVDRLSSLSPSEKNAVEAAVRAANPQIPAAARITVSANGTVTITYPDSSTDTITANRVVKDLASSR 5ij1 A 1.80 BS03 BGC A 1 T293 F294 T45 F46 27685666 RRATDTTPPTITVPSDIIAYRGEEFEFYFEITDDSGQVKNIELSTFGKPLGLNWLEYSEDNFNVPGNATSDNPLRVRVHGTVPLNEPIPADKNRAQFTRTIRAWDAAGNVSSNITFVIKYRAQTDKYNPADPTITYVDRLSSLSPSEKNAVEAAVRAANPQIPAAARITVSANGTVTITYPDSSTDTITANRVVKDLASSR 5ij1 B 1.80 BS02 CA B 2 T372 Y375 N376 D434 T121 Y124 N125 D183 27685666 TDTTPPTITVPSDIIAYRGEEFEFYFEITDDSGQVKNIELSTFGKPLGLNWLEYSEDNFNVPGNATSDNPLRVRVHGTVPLNEPIPADKNRAQFTRTIRAWDAAGNVSSNITFVIKYRAQTDKYNPADPTITYVDRLSSLSPSEKNAVEAAVRAANPQIPAAARITVSANGTVTITYPDSSTDTITANRVVKDL 5ij2 A 1.68 BS04 CA A 2 T372 D373 Y375 D434 T124 D125 Y127 D186 27685666 RRATDTTPPTITVPSDIIAYRGEEFEFYFEITDDSGQVKNIELSTFGKPLGLNWLEYSEDNFNVPGNATSDNPLRVRVHGTVPLNEPIPADKNRAQFTRTIRAWDAAGNVSSNITFVIKYRAQTDKYNPADPTITYVDRLSSLSPSEKNAVEAAVRAANPQIPAAARITVSANGTVTITYPDSSTDTITANRVVKDLASSR 5j0n E 11.00 BS01 NUC A 1 K103 K136 A138 S139 L142 V175 R176 R177 K235 S274 R276 L280 S281 R287 Y288 H308 R311 H333 K32 K65 A67 S68 L71 V104 R105 R106 K164 S203 R205 L209 S210 R216 Y217 H237 R240 H262 2.7.7.-,3.1.-.- 27223329 NSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVRRSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTEWDKIEIK 5j0n E 11.00 BS02 NUC B 1 R90 I92 K93 T96 N99 K141 R177 S234 K235 S286 R287 M290 R293 T306 H308 R19 I21 K22 T25 N28 K70 R106 S163 K164 S215 R216 M219 R222 T235 H237 2.7.7.-,3.1.-.- 27223329 NSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVRRSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTEWDKIEIK 5j0n F 11.00 BS01 NUC A 1 M1 G2 R19 N21 Y23 I92 K93 K95 T96 N99 Y100 S145 D149 R152 K172 R177 S234 K235 S286 M290 T306 H308 M1 G2 R19 N21 Y23 I92 K93 K95 T96 N99 Y100 S145 D149 R152 K172 R177 S234 K235 S286 M290 T306 H308 2.7.7.-,3.1.-.- 27223329 MGRRRSHERRDLPPNLYIRNNGYYCYRDPRTGKEFGLGRDRRIAITEAIQANIELFSGHKHKPLTARINSDNSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVRRSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTMASQYRDDRGREWDKIEIK 5j0n F 11.00 BS02 NUC D 1 M1 G2 R3 R4 S6 E8 R9 P14 Y17 N20 K105 K136 L142 R176 K235 T236 R287 Y288 H333 M338 M1 G2 R3 R4 S6 E8 R9 P14 Y17 N20 K105 K136 L142 R176 K235 T236 R287 Y288 H333 M338 2.7.7.-,3.1.-.- 27223329 MGRRRSHERRDLPPNLYIRNNGYYCYRDPRTGKEFGLGRDRRIAITEAIQANIELFSGHKHKPLTARINSDNSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVRRSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTMASQYRDDRGREWDKIEIK 5j0n G 11.00 BS01 NUC A 1 M1 G2 R3 R19 N21 E34 M1 G2 R3 R19 N21 E34 2.7.7.-,3.1.-.- 27223329 MGRRRSHERRDLPPNLYIRNNGYYCYRDPRTGKEFGLGRDRRIAITEAIQANIELFSGHKHKPLTARINSDNSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVRRSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTEWDKIEIK 5j0n G 11.00 BS02 NUC C 1 N99 K103 R176 R177 R212 K235 T236 S274 R287 Y288 D303 H308 R311 H333 K334 N99 K103 R176 R177 R212 K235 T236 S274 R287 Y288 D303 H308 R311 H333 K334 2.7.7.-,3.1.-.- 27223329 MGRRRSHERRDLPPNLYIRNNGYYCYRDPRTGKEFGLGRDRRIAITEAIQANIELFSGHKHKPLTARINSDNSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVRRSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTEWDKIEIK 5j0n G 11.00 BS03 NUC D 1 M1 R3 S6 H7 E8 Y17 I18 R19 R27 R90 I92 K93 K95 T96 N99 K141 K172 R212 V213 G214 S234 K235 S286 R287 M290 R293 T306 F307 H308 M1 R3 S6 H7 E8 Y17 I18 R19 R27 R90 I92 K93 K95 T96 N99 K141 K172 R212 V213 G214 S234 K235 S286 R287 M290 R293 T306 F307 H308 2.7.7.-,3.1.-.- 27223329 MGRRRSHERRDLPPNLYIRNNGYYCYRDPRTGKEFGLGRDRRIAITEAIQANIELFSGHKHKPLTARINSDNSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVRRSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTEWDKIEIK 5j0n H 11.00 BS01 NUC A 1 R3 Y17 R27 E34 R3 Y17 R27 E34 2.7.7.-,3.1.-.- 27223329 MGRRRSHERRDLPPNLYIRNNGYYCYRDPRTGKEFGLGRDRRIAITEAIQANIELFSGHKHKPLTARINSDNSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVRRSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTMASQYRDDRGREWDKIEIK 5j0n H 11.00 BS02 NUC B 1 R19 N21 Y23 K33 E34 K103 K136 A138 S139 L142 V175 R176 R177 R287 Y288 D303 H333 S335 M338 R19 N21 Y23 K33 E34 K103 K136 A138 S139 L142 V175 R176 R177 R287 Y288 D303 H333 S335 M338 2.7.7.-,3.1.-.- 27223329 MGRRRSHERRDLPPNLYIRNNGYYCYRDPRTGKEFGLGRDRRIAITEAIQANIELFSGHKHKPLTARINSDNSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVRRSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTMASQYRDDRGREWDKIEIK 5j0n H 11.00 BS03 NUC C 1 K93 K95 T96 N99 Y100 D149 K172 R177 S234 K235 S286 R287 M290 T306 H308 K93 K95 T96 N99 Y100 D149 K172 R177 S234 K235 S286 R287 M290 T306 H308 2.7.7.-,3.1.-.- 27223329 MGRRRSHERRDLPPNLYIRNNGYYCYRDPRTGKEFGLGRDRRIAITEAIQANIELFSGHKHKPLTARINSDNSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKSEVRRSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQISDKFAQHLLGHKSDTMASQYRDDRGREWDKIEIK 5j0n I 11.00 BS01 NUC A 1 T4 K5 K24 K57 R60 R63 N64 P65 K66 I71 R76 V78 G84 Q85 K86 T3 K4 K23 K56 R59 R62 N63 P64 K65 I70 R75 V77 G83 Q84 K85 27223329 ALTKAEMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENASPK 5j0n I 11.00 BS02 NUC D 1 R21 K45 S47 K57 P61 R63 P65 K66 R82 K88 R20 K44 S46 K56 P60 R62 P64 K65 R81 K87 27223329 ALTKAEMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENASPK 5j0n J 11.00 BS01 NUC A 1 R46 H54 R56 R59 P64 K65 H79 R46 H54 R56 R59 P64 K65 H79 27223329 MTKSELIERLATQQSHIPAKTVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG 5j0n J 11.00 BS02 NUC D 1 T2 K3 S4 K27 R42 E44 R46 G47 S50 R59 G61 R62 N63 P64 K65 V70 L72 K81 G83 K84 T2 K3 S4 K27 R42 E44 R46 G47 S50 R59 G61 R62 N63 P64 K65 V70 L72 K81 G83 K84 27223329 MTKSELIERLATQQSHIPAKTVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG 5j0n K 11.00 BS01 NUC A 1 K20 K45 R55 K57 P61 P65 K66 R82 K19 K44 R54 K56 P60 P64 K65 R81 27223329 ALTKAEMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENASPK 5j0n K 11.00 BS02 NUC B 1 T4 K57 R60 R63 N64 P65 K66 I71 I73 R76 Q85 T3 K56 R59 R62 N63 P64 K65 I70 I72 R75 Q84 27223329 ALTKAEMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENASPK 5j0n L 11.00 BS01 NUC A 1 R42 E44 R46 R59 G61 R62 N63 P64 V70 L72 R42 E44 R46 R59 G61 R62 N63 P64 V70 L72 27223329 MTKSELIERLATQQSHIPAKTVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG 5j0n L 11.00 BS02 NUC B 1 E44 R46 H54 R56 R59 P64 E44 R46 H54 R56 R59 P64 27223329 MTKSELIERLATQQSHIPAKTVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG 5j0n M 11.00 BS01 NUC A 1 R16 T20 R23 W24 E27 R39 R16 T20 R23 W24 E27 R39 27223329 MYLTLQEWNARQRRPRSLETVRRWVRESRIFPPPVKDGREYLFHESAVKVDLN 5j0n M 11.00 BS02 NUC B 1 Q6 R22 R39 E40 Y41 Q6 R22 R39 E40 Y41 27223329 MYLTLQEWNARQRRPRSLETVRRWVRESRIFPPPVKDGREYLFHESAVKVDLN 5j0n N 11.00 BS01 NUC A 1 R16 R39 R16 R39 27223329 MYLTLQEWNARQRRPRSLETVRRWVRESRIFPPPVKDGREYLFHESAVKVDLNR 5j0n N 11.00 BS02 NUC B 1 L5 R22 R26 L5 R22 R26 27223329 MYLTLQEWNARQRRPRSLETVRRWVRESRIFPPPVKDGREYLFHESAVKVDLNR 5j16 A 2.40 BS01 CA A 1 E65 D83 D86 D208 E52 D70 D73 D195 MALYGFAQGLIQEAGIRIKQLMEQNTNVDKATEDFIFDTILETYPNHQVLGEEGHGHDIDTSKGTVWVVDPIDGTLNFVHQQENFAISIGIYIDGKPYAGFVYDVMADVLYHAKVGEGAYRGSQPLKPLNDSNLRQSIIGINPNWLTKPILGEIFKEIVNDSRSARAYGSAALEIVSVATGNLEAYMTPRLQPWDFAGGLVILYEVNGQASNLLGEPLTISGPNSILVGNRGLHQEISNDYLEPHHDALIQLHEQRFK 5j16 A 2.40 BS02 CA A 2 D42 E65 D83 I85 D29 E52 D70 I72 MALYGFAQGLIQEAGIRIKQLMEQNTNVDKATEDFIFDTILETYPNHQVLGEEGHGHDIDTSKGTVWVVDPIDGTLNFVHQQENFAISIGIYIDGKPYAGFVYDVMADVLYHAKVGEGAYRGSQPLKPLNDSNLRQSIIGINPNWLTKPILGEIFKEIVNDSRSARAYGSAALEIVSVATGNLEAYMTPRLQPWDFAGGLVILYEVNGQASNLLGEPLTISGPNSILVGNRGLHQEISNDYLEPHHDALIQLHEQRFK 5j16 A 2.40 BS03 IPD A 1 E65 D83 I85 D86 G87 T88 G182 S183 A184 E52 D70 I72 D73 G74 T75 G169 S170 A171 MALYGFAQGLIQEAGIRIKQLMEQNTNVDKATEDFIFDTILETYPNHQVLGEEGHGHDIDTSKGTVWVVDPIDGTLNFVHQQENFAISIGIYIDGKPYAGFVYDVMADVLYHAKVGEGAYRGSQPLKPLNDSNLRQSIIGINPNWLTKPILGEIFKEIVNDSRSARAYGSAALEIVSVATGNLEAYMTPRLQPWDFAGGLVILYEVNGQASNLLGEPLTISGPNSILVGNRGLHQEISNDYLEPHHDALIQLHEQRFK 5j16 B 2.40 BS02 CA B 2 E65 D83 I85 D86 E56 D71 I73 D74 GSMALYGFAQGLIQEAGIRIKQLMEQNLVTNVDKATEDFIFDTILETYPNHQVLGEEGHIDTSKGTVWVVDPIDGTLNFVHQQENFAISIGIYIDGKPYAGFVYDVMADVLYHAKVGEGAYRGSQPLKPLNDSNLRQSIIGINPNWLTKPILGEIFKEIVNDSRSARAYGSAALEIVSVATGNLEAYMTPRLQPWDFAGGLVILYEVNGQASNLLGEPLTISGPNSILVGNRGLHQEISNDYLEPHHDALIQLH 5j16 C 2.40 BS03 IPD C 1 D83 I85 D86 G87 T88 G182 S183 A184 L204 D66 I68 D69 G70 T71 G165 S166 A167 L187 LYGFAQGLIQEAGIRIKQLMEQNLTNVDKATEDFIFDTILETYPNHQVLGEEGDIDTSKGTVWVVDPIDGTLNFVHQQENFAISIGIYIDGKPYAGFVYDVMADVLYHAKVGEGAYRGSQPLKPLNDSNLRQSIIGINPNWLTKPILGEIFKEIVNDSRSARAYGSAALEIVSVATGNLEAYMTPRLQPWDFAGGLVILYEVNGQASNLLGEPLTISGPNSILVGNRGLHQEISNDYLEPHHDALIQLHEQRF 5j50 E 2.05 BS04 NPO E 1 S76 Y78 Y122 S76 Y78 Y122 GKAFDDGAFTGIREINLSYNKETAIGDFQVVYDLNGSPYVGQNHKSFITGFTPVKISLDFPSEYIMEVSGYTGNVSGYVVVRSLTFKTNKKTYGPYGVTSGTPFNLPIENGLIVGFKGSIGYWLDYFSMYLSL 5j72 A 1.70 BS01 CA A 1 N15 D190 K395 N6 D181 K386 3.5.1.28 28132783 SDININLQRKSVVLGSKSNASVKFKEKLNADSITLNFMCYDMPLEATLNYNEKTDSYEGVINYNKDPEYLNVWELQSIKINGKDEQKVLNKEDLESMGLNLKDYDVTQEFIISDANSTKAVNEYMRKTSAPVKKLAGATRFETAVEISKQGWKDGSSKVVIVNGELAADGITATPLASTYDAPILLANKDDIPESTKAELKRLNPSDVIIIGDDGSVSQKAVSQIKSAVNVNVTRIGGVDRHETSLLIAKEIDKYHDVNKIYIANGYAGEYDALNISSKAGEDQQPIILANKDSVPQGTYNWLSSQGLEEAYYIGGSQSLSSKIIDQISKIAKNGTSKNRVSGADRHETNANVIKTFYPDKELSAMLVAKSDIIVDSITAGPLAAKLKAPILITPKTYVSAYHSTNLSEKTAETVYQIGDGMKDSVINSIASSLSKHNAPTEPDNSGSAAGKTVVIDPGHGGSDSGATSGLNGGAQEKKYTLNTALATTEYLRSKGINVVMTRDTDKTMALGERTALSNTIKPDLFTSIHYNASNGSGNGVEIYYKVKDKNGGTTKTAASNILKRILEKFNMKNRGIKTRTLDNGKDYLYVLRNNNYPAILVECAFIDNKSDMDKLNTAEKVKTMGTQIGIGIEDTVK 5j72 A 1.70 BS02 CA A 2 S338 K339 A341 S329 K330 A332 3.5.1.28 28132783 SDININLQRKSVVLGSKSNASVKFKEKLNADSITLNFMCYDMPLEATLNYNEKTDSYEGVINYNKDPEYLNVWELQSIKINGKDEQKVLNKEDLESMGLNLKDYDVTQEFIISDANSTKAVNEYMRKTSAPVKKLAGATRFETAVEISKQGWKDGSSKVVIVNGELAADGITATPLASTYDAPILLANKDDIPESTKAELKRLNPSDVIIIGDDGSVSQKAVSQIKSAVNVNVTRIGGVDRHETSLLIAKEIDKYHDVNKIYIANGYAGEYDALNISSKAGEDQQPIILANKDSVPQGTYNWLSSQGLEEAYYIGGSQSLSSKIIDQISKIAKNGTSKNRVSGADRHETNANVIKTFYPDKELSAMLVAKSDIIVDSITAGPLAAKLKAPILITPKTYVSAYHSTNLSEKTAETVYQIGDGMKDSVINSIASSLSKHNAPTEPDNSGSAAGKTVVIDPGHGGSDSGATSGLNGGAQEKKYTLNTALATTEYLRSKGINVVMTRDTDKTMALGERTALSNTIKPDLFTSIHYNASNGSGNGVEIYYKVKDKNGGTTKTAASNILKRILEKFNMKNRGIKTRTLDNGKDYLYVLRNNNYPAILVECAFIDNKSDMDKLNTAEKVKTMGTQIGIGIEDTVK 5j72 A 1.70 BS03 ZN A 1 H469 E486 H539 H460 E477 H530 3.5.1.28 28132783 SDININLQRKSVVLGSKSNASVKFKEKLNADSITLNFMCYDMPLEATLNYNEKTDSYEGVINYNKDPEYLNVWELQSIKINGKDEQKVLNKEDLESMGLNLKDYDVTQEFIISDANSTKAVNEYMRKTSAPVKKLAGATRFETAVEISKQGWKDGSSKVVIVNGELAADGITATPLASTYDAPILLANKDDIPESTKAELKRLNPSDVIIIGDDGSVSQKAVSQIKSAVNVNVTRIGGVDRHETSLLIAKEIDKYHDVNKIYIANGYAGEYDALNISSKAGEDQQPIILANKDSVPQGTYNWLSSQGLEEAYYIGGSQSLSSKIIDQISKIAKNGTSKNRVSGADRHETNANVIKTFYPDKELSAMLVAKSDIIVDSITAGPLAAKLKAPILITPKTYVSAYHSTNLSEKTAETVYQIGDGMKDSVINSIASSLSKHNAPTEPDNSGSAAGKTVVIDPGHGGSDSGATSGLNGGAQEKKYTLNTALATTEYLRSKGINVVMTRDTDKTMALGERTALSNTIKPDLFTSIHYNASNGSGNGVEIYYKVKDKNGGTTKTAASNILKRILEKFNMKNRGIKTRTLDNGKDYLYVLRNNNYPAILVECAFIDNKSDMDKLNTAEKVKTMGTQIGIGIEDTVK 5j72 B 1.70 BS01 CA B 1 N15 D163 N6 D154 3.5.1.28 28132783 SDININLQRKSVVLGSKSNASVKFKEKLNADSITLNFMCYDMPLEATLNYNEKTDSYEGVINYNKDPEYLNVWELQSIKINGKDEQKVLNKEDLESMGLNLKDYDVTQEFIISDANSTKAVNEYMRKTSAPVKKLAGATRFETAVEISKQGWKDGSSKVVIVNGELAADGITATPLASTYDAPILLANKDDIPESTKAELKRLNPSDVIIIGDDGSVSQKAVSQIKSAVNVNVTRIGGVDRHETSLLIAKEIDKYHDVNKIYIANGYAGEYDALNISSKAGEDQQPIILANKDSVPQGTYNWLSSQGLEEAYYIGGSQSLSSKIIDQISKIAKNGTSKNRVSGADRHETNANVIKTFYPDKELSAMLVAKSDIIVDSITAGPLAAKLKAPILITPKTYVSAYHSTNLSEKTAETVYQIGDGMKDSVINSIASSLSKHNAPTEPDNSGSAAGKTVVIDPGHGGSDSGATSGLNGGAQEKKYTLNTALATTEYLRSKGINVVMTRDTDKTMALGERTALSNTIKPDLFTSIHYNASNGSGNGVEIYYKVKDKNGGTTKTAASNILKRILEKFNMKNRGIKTRTLDNGKDYLYVLRNNNYPAILVECAFIDNKSDMDKLNTAEKVKTMGTQIGIGIEDTVK 5j72 B 1.70 BS03 CA B 3 T590 L591 D592 T581 L582 D583 3.5.1.28 28132783 SDININLQRKSVVLGSKSNASVKFKEKLNADSITLNFMCYDMPLEATLNYNEKTDSYEGVINYNKDPEYLNVWELQSIKINGKDEQKVLNKEDLESMGLNLKDYDVTQEFIISDANSTKAVNEYMRKTSAPVKKLAGATRFETAVEISKQGWKDGSSKVVIVNGELAADGITATPLASTYDAPILLANKDDIPESTKAELKRLNPSDVIIIGDDGSVSQKAVSQIKSAVNVNVTRIGGVDRHETSLLIAKEIDKYHDVNKIYIANGYAGEYDALNISSKAGEDQQPIILANKDSVPQGTYNWLSSQGLEEAYYIGGSQSLSSKIIDQISKIAKNGTSKNRVSGADRHETNANVIKTFYPDKELSAMLVAKSDIIVDSITAGPLAAKLKAPILITPKTYVSAYHSTNLSEKTAETVYQIGDGMKDSVINSIASSLSKHNAPTEPDNSGSAAGKTVVIDPGHGGSDSGATSGLNGGAQEKKYTLNTALATTEYLRSKGINVVMTRDTDKTMALGERTALSNTIKPDLFTSIHYNASNGSGNGVEIYYKVKDKNGGTTKTAASNILKRILEKFNMKNRGIKTRTLDNGKDYLYVLRNNNYPAILVECAFIDNKSDMDKLNTAEKVKTMGTQIGIGIEDTVK 5jgh A 2.60 BS01 NUC B 1 K27 A28 S29 K30 R31 F123 L144 M147 K148 G151 W154 Q155 Y169 I173 K1 A2 S3 K4 R5 F97 L118 M121 K122 G125 W128 Q129 Y143 I147 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPL 5jgh A 2.60 BS02 NUC C 1 K27 A28 K117 K118 I124 N128 Q143 K1 A2 K91 K92 I98 N102 Q117 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPL 5jgh A 2.60 BS03 NUC E 1 R45 S48 Y50 F51 A71 S74 K75 G78 W81 Q82 R96 Y100 R19 S22 Y24 F25 A45 S48 K49 G52 W55 Q56 R70 Y74 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPL 5jgh A 2.60 BS04 NUC F 1 R45 P46 T47 S48 F51 Q55 R58 P70 R19 P20 T21 S22 F25 Q29 R32 P44 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPL 5jgh D 2.60 BS01 NUC B 1 R45 S48 Y50 F51 A71 S74 K75 G78 E79 W81 Q82 R96 Y100 Y103 Q104 K107 R19 S22 Y24 F25 A45 S48 K49 G52 E53 W55 Q56 R70 Y74 Y77 Q78 K81 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYP 5jgh D 2.60 BS02 NUC C 1 K44 R45 T47 S48 F51 Q55 R58 P70 K18 R19 T21 S22 F25 Q29 R32 P44 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYP 5jgh D 2.60 BS03 NUC E 1 S29 K30 K118 P122 F123 L144 M147 K148 G151 W154 Q155 I166 Y169 I173 S3 K4 K92 P96 F97 L118 M121 K122 G125 W128 Q129 I140 Y143 I147 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYP 5jgh D 2.60 BS04 NUC F 1 K27 A28 S29 T32 K117 K118 I124 R131 Q143 L144 M147 K1 A2 S3 T6 K91 K92 I98 R105 Q117 L118 M121 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYP 5jgh G 2.60 BS01 NUC H 1 K27 K30 K118 P122 F123 L144 M147 K148 W154 Q155 I166 Y169 K170 K1 K4 K92 P96 F97 L118 M121 K122 W128 Q129 I140 Y143 K144 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPL 5jgh G 2.60 BS02 NUC I 1 K27 S29 R31 T32 K117 K118 I124 R131 Q143 K1 S3 R5 T6 K91 K92 I98 R105 Q117 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPL 5jgh G 2.60 BS03 NUC K 1 R45 S48 Y50 F51 P70 A71 S74 K75 G78 W81 Y100 Q104 R19 S22 Y24 F25 P44 A45 S48 K49 G52 W55 Y74 Q78 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPL 5jgh G 2.60 BS04 NUC L 1 R45 T47 S48 F51 R58 P70 R19 T21 S22 F25 R32 P44 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPL 5jgh J 2.60 BS01 NUC H 1 R45 S48 Y50 F51 A71 S74 K75 G78 W81 Q82 Y100 K107 R15 S18 Y20 F21 A41 S44 K45 G48 W51 Q52 Y70 K77 27899643 RTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYP 5jgh J 2.60 BS02 NUC I 1 R45 T47 S48 F51 R58 R69 P70 R15 T17 S18 F21 R28 R39 P40 27899643 RTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYP 5jgh J 2.60 BS03 NUC K 1 K118 P122 F123 I124 L144 M147 K148 W154 Q155 I166 Y169 I173 Y180 K88 P92 F93 I94 L114 M117 K118 W124 Q125 I136 Y139 I143 Y150 27899643 RTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYP 5jgh J 2.60 BS04 NUC L 1 R31 K117 K118 I124 N128 R131 Q143 M147 R1 K87 K88 I94 N98 R101 Q113 M117 27899643 RTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYP 5jh0 A 2.18 BS01 NUC B 1 K27 K30 R31 K118 F123 L144 M147 K148 W154 Q155 I166 Y169 K1 K4 R5 K92 F97 L118 M121 K122 W128 Q129 I140 Y143 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPL 5jh0 A 2.18 BS02 NUC C 1 K27 T32 K117 K118 I124 N128 R131 Q143 K1 T6 K91 K92 I98 N102 R105 Q117 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPL 5jh0 A 2.18 BS04 NUC F 1 K44 R45 T47 F51 L54 Q55 R58 R69 P70 K18 R19 T21 F25 L28 Q29 R32 R43 P44 27899643 KASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPL 5jh0 D 2.18 BS02 NUC C 1 K44 R45 T47 F51 Q55 R58 R69 P70 K20 R21 T23 F27 Q31 R34 R45 P46 27899643 HHKASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYP 5jh0 D 2.18 BS03 NUC E 1 S29 K30 K118 P122 F123 L144 M147 K148 G151 W154 Q155 Y169 S5 K6 K94 P98 F99 L120 M123 K124 G127 W130 Q131 Y145 27899643 HHKASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYP 5jh0 D 2.18 BS04 NUC F 1 H0 K27 A28 S29 R31 T32 K117 K118 I124 N128 Q143 H2 K3 A4 S5 R7 T8 K93 K94 I100 N104 Q119 27899643 HHKASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYP 5jq5 A 1.94 BS01 I74 A 1 I10 V18 A31 F80 E81 F82 L83 H84 Q85 Q131 N132 L134 A144 D145 I8 V16 A29 F69 E70 F71 L72 H73 Q74 Q120 N121 L123 A133 D134 2.7.11.22 28125165 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 5jq8 A 1.94 BS01 I73 A 1 I10 E12 G13 V18 A31 K33 F80 E81 F82 L83 H84 Q85 K89 Q131 N132 L134 A144 D145 I8 E10 G11 V16 A29 K31 F69 E70 F71 L72 H73 Q74 K78 Q120 N121 L123 A133 D134 2.7.11.22 28125165 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 5k2o A 2.87 BS02 FAD A 1 R246 G307 G308 G309 T331 L332 M333 L349 G350 M351 H352 G371 V372 R373 D375 V378 D395 I396 D397 E400 G413 D414 V415 Q489 M490 S507 G508 G509 G511 R161 G222 G223 G224 T246 L247 M248 L264 G265 M266 H267 G286 V287 R288 D290 V293 D310 I311 D312 E315 G328 D329 V330 Q404 M405 S422 G423 G424 G426 2.2.1.6 28137884 TFISRFAPDQPRKGADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSGKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAMRLPGYMSRMPKPPEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTLMGLGSYPCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGAMGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVMQWEDRFYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTPGPYLLDVICPHQEHVLPMIPSGGTFNDVITEGDGRLEH 5k2o A 2.87 BS03 6QK A 1 M351 R377 M570 V571 W574 S653 M266 R292 M485 V486 W489 S568 2.2.1.6 28137884 TFISRFAPDQPRKGADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSGKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAMRLPGYMSRMPKPPEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTLMGLGSYPCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGAMGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVMQWEDRFYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTPGPYLLDVICPHQEHVLPMIPSGGTFNDVITEGDGRLEH 5k3s A 2.87 BS02 FAD A 1 R246 G307 G308 G309 T331 L332 M333 M348 L349 G350 M351 H352 G371 R373 D375 R377 V378 D395 I396 D397 E400 G413 D414 V415 V485 Q489 M490 G508 G509 G511 R161 G222 G223 G224 T246 L247 M248 M263 L264 G265 M266 H267 G286 R288 D290 R292 V293 D310 I311 D312 E315 G328 D329 V330 V400 Q404 M405 G423 G424 G426 2.2.1.6 28137884 TFISRFAPDQPRKGADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSGKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAMRLPGYMSRMPKPPEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTLMGLGSYPCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGAMGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVMQWEDRFYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTPGPYLLDVICPHQEHVLPMIPSGGTFNDVITEGDGRL 5k3s A 2.87 BS03 6QL A 1 M351 D376 R377 M570 V571 W574 S653 G654 M266 D291 R292 M485 V486 W489 S568 G569 2.2.1.6 28137884 TFISRFAPDQPRKGADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSGKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAMRLPGYMSRMPKPPEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTLMGLGSYPCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGAMGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVMQWEDRFYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTPGPYLLDVICPHQEHVLPMIPSGGTFNDVITEGDGRL 5k6r A 2.73 BS02 FAD A 1 R246 G307 G308 G309 T331 L332 M333 M348 L349 G350 M351 H352 G371 R373 R377 V378 D395 I396 D397 E400 G413 D414 V415 Q489 M490 G508 G509 R161 G222 G223 G224 T246 L247 M248 M263 L264 G265 M266 H267 G286 R288 R292 V293 D310 I311 D312 E315 G328 D329 V330 Q404 M405 G423 G424 2.2.1.6 28137884 TFISRFAPDQPRKGADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSGKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAMRLPGYMSRMPKPPEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTLMGLGSYPCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGAMGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVMQWEDRFYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTPGPYLLDVICPHQEHVLPMIPSGGTFNDVITEGDGR 5k6r A 2.73 BS03 6R5 A 1 R377 W574 S653 R292 W489 S568 2.2.1.6 28137884 TFISRFAPDQPRKGADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSGKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAMRLPGYMSRMPKPPEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTLMGLGSYPCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGAMGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVMQWEDRFYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTPGPYLLDVICPHQEHVLPMIPSGGTFNDVITEGDGR 5k6t A 2.76 BS02 FAD A 1 R246 G307 G308 G309 T331 L332 M333 M348 L349 M351 H352 G371 R373 D375 R377 V378 D395 I396 D397 E400 G413 D414 V415 Q489 M490 S507 G508 G509 G511 R161 G222 G223 G224 T246 L247 M248 M263 L264 M266 H267 G286 R288 D290 R292 V293 D310 I311 D312 E315 G328 D329 V330 Q404 M405 S422 G423 G424 G426 2.2.1.6 28137884 TFISRFAPDQPRKGADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSGKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAMRLPGYMSRMPKPPEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTLMGLGSYPCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGAMGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVMQWEDRFYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTPGPYLLDVICPHQEHVLPMIPSGGTFNDVITEGDGR 5k6t A 2.76 BS03 6R4 A 1 M351 H352 R377 M570 W574 S653 M266 H267 R292 M485 W489 S568 2.2.1.6 28137884 TFISRFAPDQPRKGADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSGKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAMRLPGYMSRMPKPPEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTLMGLGSYPCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGAMGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVMQWEDRFYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTPGPYLLDVICPHQEHVLPMIPSGGTFNDVITEGDGR 5k6t A 2.76 BS04 TZD A 1 V485 G486 Q487 H488 G511 M513 G537 D538 G539 S540 N565 H567 L568 G569 M570 V400 G401 Q402 H403 G426 M428 G452 D453 G454 S455 N480 H482 L483 G484 M485 2.2.1.6 28137884 TFISRFAPDQPRKGADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSGKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAMRLPGYMSRMPKPPEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTLMGLGSYPCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGAMGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVMQWEDRFYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTPGPYLLDVICPHQEHVLPMIPSGGTFNDVITEGDGR 5kn8 A 1.81 BS01 NUC C 1 G87 Y88 A162 K163 C164 S165 G80 Y81 A155 K156 C157 S158 3.2.2.- FPAREFQRDLLDWFARERRDLPWRKDRDPYKVWVSEVMLQQTRVETVIPYFEQFIDRFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKTRYGGKVPDDPDEFSRLKGVGPYTVGAVLSLAYGVPEPAVNGNVMRVLSRLFLVTDDIAKCSTRKRFEQIVREIMAYENPGAFNEALIELGALVCTPRRPSCLLCPVQAYCQAFAEGVAEELPVKM 5kn8 A 1.81 BS02 NUC D 1 Q47 G122 V123 G124 P125 Y126 T127 N144 G145 C164 R167 K228 Q40 G115 V116 G117 P118 Y119 T120 N137 G138 C157 R160 K221 3.2.2.- FPAREFQRDLLDWFARERRDLPWRKDRDPYKVWVSEVMLQQTRVETVIPYFEQFIDRFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKTRYGGKVPDDPDEFSRLKGVGPYTVGAVLSLAYGVPEPAVNGNVMRVLSRLFLVTDDIAKCSTRKRFEQIVREIMAYENPGAFNEALIELGALVCTPRRPSCLLCPVQAYCQAFAEGVAEELPVKM 5kn8 A 1.81 BS03 SF4 A 1 R153 L154 V197 C198 P203 C205 C208 Q211 C214 F217 A222 R146 L147 V190 C191 P196 C198 C201 Q204 C207 F210 A215 3.2.2.- FPAREFQRDLLDWFARERRDLPWRKDRDPYKVWVSEVMLQQTRVETVIPYFEQFIDRFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKTRYGGKVPDDPDEFSRLKGVGPYTVGAVLSLAYGVPEPAVNGNVMRVLSRLFLVTDDIAKCSTRKRFEQIVREIMAYENPGAFNEALIELGALVCTPRRPSCLLCPVQAYCQAFAEGVAEELPVKM 5kn8 A 1.81 BS04 CA A 1 S118 V123 S111 V116 3.2.2.- FPAREFQRDLLDWFARERRDLPWRKDRDPYKVWVSEVMLQQTRVETVIPYFEQFIDRFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKTRYGGKVPDDPDEFSRLKGVGPYTVGAVLSLAYGVPEPAVNGNVMRVLSRLFLVTDDIAKCSTRKRFEQIVREIMAYENPGAFNEALIELGALVCTPRRPSCLLCPVQAYCQAFAEGVAEELPVKM 5kn9 A 1.93 BS02 NUC D 1 Q47 G122 G124 P125 Y126 T127 N144 G145 R167 K228 Q40 G115 G117 P118 Y119 T120 N137 G138 R160 K221 3.2.2.- FPAREFQRDLLDWFARERRDLPWRKDRDPYKVWVSEVMLQQTRYETVIPYFEQFIDRFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKTRYGGKVPDDPDEFSRLKGVGPYTVGAVLSLAYGVPEPAVNGNVMRVLSRLFLVTDDIAKCSTRKRFEQIVREIMAYENPGAFNEALIELGALVCTPRRPSCLLCPVQAYCQAFAEGVAEELPVKM 5kn9 A 1.93 BS04 CA A 1 S118 V123 G124 S111 V116 G117 3.2.2.- FPAREFQRDLLDWFARERRDLPWRKDRDPYKVWVSEVMLQQTRYETVIPYFEQFIDRFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKTRYGGKVPDDPDEFSRLKGVGPYTVGAVLSLAYGVPEPAVNGNVMRVLSRLFLVTDDIAKCSTRKRFEQIVREIMAYENPGAFNEALIELGALVCTPRRPSCLLCPVQAYCQAFAEGVAEELPVKM 5lge A 2.70 BS01 NAP A 1 K72 A74 T75 T77 R82 N96 L288 E306 A307 H309 G310 T311 V312 T313 R314 H315 N328 K70 A72 T73 T75 R80 N94 L278 E296 A297 H299 G300 T301 V302 T303 R304 H305 N318 1.1.1.42 28124097 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPTYLHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKLSL 5lge A 2.70 BS02 6VN B 1 L120 M259 V276 Q277 S280 V281 L118 M249 V266 Q267 S270 V271 1.1.1.42 28124097 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPTYLHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKLSL 5lge B 2.70 BS01 NAP B 1 K72 A74 T75 T77 R82 N96 Q277 D279 L288 G289 E306 A307 H309 G310 T311 V312 T313 R314 H315 N328 K70 A72 T73 T75 R80 N94 Q268 D270 L279 G280 E297 A298 H300 G301 T302 V303 T304 R305 H306 N319 1.1.1.42 28124097 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKLSL 5lge B 2.70 BS02 6VN B 1 L120 W124 I128 I130 H132 M259 C269 S280 V281 Y285 L118 W122 I126 I128 H130 M250 C260 S271 V272 Y276 1.1.1.42 28124097 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKLSL 5lge D 2.70 BS01 NAP D 1 K72 A74 T75 T77 R82 N96 Q277 L288 E306 A307 H309 G310 T311 V312 T313 R314 H315 T327 N328 K70 A72 T73 T75 R80 N94 Q274 L285 E303 A304 H306 G307 T308 V309 T310 R311 H312 T324 N325 1.1.1.42 28124097 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKLS 5lge D 2.70 BS02 6VN D 1 W124 I128 I130 H132 C269 S280 V281 Y285 W122 I126 I128 H130 C267 S277 V278 Y282 1.1.1.42 28124097 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKLS 5lxh A 1.58 BS01 III E 1 I21 K24 Y25 R28 K46 K48 Y49 L50 V51 P52 L63 R67 F104 I22 K25 Y26 R29 K47 K49 Y50 L51 V52 P53 L64 R68 F105 SMKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESV 5lxh B 1.58 BS01 III F 1 E17 K20 I21 K24 Y25 R28 I32 K46 K48 Y49 L50 P52 F60 R67 F104 E17 K20 I21 K24 Y25 R28 I32 K46 K48 Y49 L50 P52 F60 R67 F104 MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVY 5lxh C 1.58 BS01 III G 1 E17 K20 I21 K24 Y25 R28 P30 K46 K48 Y49 L50 P52 F60 L63 R67 F104 E17 K20 I21 K24 Y25 R28 P30 K43 K45 Y46 L47 P49 F57 L60 R64 F101 MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGK 5lxi D 1.44 BS01 III C 1 Y5 H9 E17 I21 R28 P30 K46 R47 K48 Y49 L50 P52 F60 R67 F104 Y5 H9 E17 I21 R28 P30 K46 R47 K48 Y49 L50 P52 F60 R67 F104 MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGK 5lxi D 1.44 BS02 MG D 1 D45 H69 D45 H69 MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGK 5lxi B 1.44 BS01 III C 1 F11 R14 F11 R14 MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYG 5lxi B 1.44 BS02 III E 1 Y5 H9 E17 I21 Y25 R28 P30 K46 R47 K48 Y49 L50 P52 F60 L63 R67 F104 Y5 H9 E17 I21 Y25 R28 P30 K46 R47 K48 Y49 L50 P52 F60 L63 R67 F104 MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYG 5m18 A 1.98 BS01 MUR A 1 R151 T165 E239 S240 R241 V277 H293 R125 T139 E213 S214 R215 V251 H267 28099001 DKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEVEMTERPIKIYNSLGVKDINIQDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKEDGMWKLDWDHSVIIPGMQKDQSIHIENLKSERGKILDRNNVELANTGTAYEIGIVPKNVSKKDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSDFAKKFHLTTNETESRNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDAVIGKKGLEKLYDKKLQHEDGYRVTIVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMSNEEYNKLTEDKKEPLLNKFQITTSPGSTQKILTAMIGLNNKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGSKKFEKGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLKDTKNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGTAELKMKETGRQIGWFISYDKDNPNMMMAINVKDVQDKGMASYNAKISGKVYDELYENGNKKYDIDE 5m18 B 1.98 BS01 MUR B 1 R151 T165 E239 S240 R241 V277 Q292 H293 R125 T139 E213 S214 R215 V251 Q266 H267 28099001 DKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEVEMTERPIKIYNSLGVKDINIQDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKEDGMWKLDWDHSVIIPGMQKDQSIHIENLKSERGKILDRNNVELANTGTAYEIGIVPKNVSKKDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSDFAKKFHLTTNETESRNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDAVIGKKGLEKLYDKKLQHEDGYRVTIVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMSNEEYNKLTEDKKEPLLNKFQITTSPGSTQKILTAMIGLNNKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGSKKFEKGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLKDTKNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGTAELGRQIGWFISYDKDNPNMMMAINVKDVQDKGMASYNAKISGKVYDELYENGNKKYDIDE 5m19 A 2.00 BS01 MUR A 1 R151 T165 E239 S240 R241 V256 V277 M372 R125 T139 E213 S214 R215 V230 V251 M346 28099001 DKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEVEMTERPIKIYNSLGVKDINIQDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKEDGMWKLDWDHSVIIPGMQKDQSIHIENLKSERGKILDRNNVELANTGTAYEIGIVPKNVSKKDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSDFAKKFHLTTNETESRNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDAVIGKKGLEKLYDKKLQHEDGYRVTIVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMSNEEYNKLTEDKKEPLLNKFQITTSPGSTQKILTAMIGLNNKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGSKKFEKGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLKDTKNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGTAELKMTGRQIGWFISYDKDNPNMMMAINVKDVQDKGMASYNAKISGKVYDELYENGNKKYDIDE 5m19 B 2.00 BS01 MUR B 1 E150 R151 N164 T165 E239 S240 R241 V256 V277 H293 E124 R125 N138 T139 E213 S214 R215 V230 V251 H267 28099001 DKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEVEMTERPIKIYNSLGVKDINIQDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKEDGMWKLDWDHSVIIPGMQKDQSIHIENLKSERGKILDRNNVELANTGTAYEIGIVPKNVSKKDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSDFAKKFHLTTNETESRNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDAVIGKKGLEKLYDKKLQHEDGYRVTIVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMSNEEYNKLTEDKKEPLLNKFQITTSPGSTQKILTAMIGLNNKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGSKKFEKGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLKDTKNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGTAELGRQIGWFISYDKDNPNMMMAINVKDVQDKGMASYNAKISGKVYDELYENGNKKYDIDE 5m1m A 1.50 BS01 MG A 1 N80 E126 D130 N79 E125 D129 28120862 AHEILIAETEAFLKNVAPETRTAIISAITGGKSACKSAAKLIKNEHLPLMSGEATTMHIVMRCLYPEIKPWKKASDMLNKATSSLKKSEGRDIRKQMKAAGDFLGVESMMKMRAFRDDQIMEMVEEVYDHPDDYTPDIRIGTITAWLRCKNKKS 5m1m A 1.50 BS02 MG A 2 T83 E123 E126 T82 E122 E125 28120862 AHEILIAETEAFLKNVAPETRTAIISAITGGKSACKSAAKLIKNEHLPLMSGEATTMHIVMRCLYPEIKPWKKASDMLNKATSSLKKSEGRDIRKQMKAAGDFLGVESMMKMRAFRDDQIMEMVEEVYDHPDDYTPDIRIGTITAWLRCKNKKS 5m29 A 1.50 BS01 CBY A 1 P31 A32 Y50 W66 W85 G87 F162 F168 W196 S241 D242 E245 R246 P10 A11 Y29 W45 W64 G66 F141 F147 W175 S204 D205 E208 R209 28128319 AAPRVITLSPANTELAFAAGITPVGVSSYSDYPPQAQKIEQVSTWQGMNLERIVALKPDLVIAWRGGNAERQVDQLASLGIKVMWVDATSIEQIANALRQLAPWSPQPDKAEQAAQSLLDQYAQLKAQYADKPKKRVFLQFGINPPFTSGKESIQNQVLEVCGGENIFKDSRVPWPQVSREQVLARSPQAIVITGKIPVIPLTSDWFERASPRIILAAQQLCNALSQVD 5m7j A 3.50 BS01 HEC A 1 Y56 K57 N58 V59 K60 V61 L62 F70 M74 I77 T78 V81 S82 C87 C90 H91 L96 Y104 A107 R108 Y56 K57 N58 V59 K60 V61 L62 F70 M74 I77 T78 V81 S82 C87 C90 H91 L96 Y104 A107 R108 CFEPPPATTTQTGFRGLSMGEVLHPATVKAKKERDAQYPPALAAVKAEGPPVSQVYKNVKVLGNLTEAEFLRTMTAITEWVSPQEGCTYCHDENNLASEAKYPYVVARRMLEMTRAINTNWTQHVAQTGVTCYTCHRGTPLPPYVRYLEPTLPLNNRETPTHVERVETRSGYVVRLAKYTAYSALNYDPFTMFLANDKRQVRVVPQTALPLVGVSRGKERRPLSDAYATFALMMSISDSLGTNCTFCHNAQTFESWGKKSTPQRAIAWWGIRMVRDLNMNYLAPLNASLPASRLGRQGEAPQADCRTCHQGVTKPLFGASRLKDYPELGPIK 5m7j A 3.50 BS02 HEC A 2 V81 Y89 Y102 V106 A107 M110 L111 M113 T114 C132 C135 H136 P140 L141 P142 V145 L289 R293 P301 V81 Y89 Y102 V106 A107 M110 L111 M113 T114 C132 C135 H136 P140 L141 P142 V145 L289 R293 P301 CFEPPPATTTQTGFRGLSMGEVLHPATVKAKKERDAQYPPALAAVKAEGPPVSQVYKNVKVLGNLTEAEFLRTMTAITEWVSPQEGCTYCHDENNLASEAKYPYVVARRMLEMTRAINTNWTQHVAQTGVTCYTCHRGTPLPPYVRYLEPTLPLNNRETPTHVERVETRSGYVVRLAKYTAYSALNYDPFTMFLANDKRQVRVVPQTALPLVGVSRGKERRPLSDAYATFALMMSISDSLGTNCTFCHNAQTFESWGKKSTPQRAIAWWGIRMVRDLNMNYLAPLNASLPASRLGRQGEAPQADCRTCHQGVTKPLFGASRLKDYPELGPIK 5m7j A 3.50 BS03 HEC A 3 V201 R202 V203 V204 T229 F230 M233 M234 I236 S237 L240 T242 C244 C247 H248 F253 E254 R264 A267 W268 V201 R202 V203 V204 T229 F230 M233 M234 I236 S237 L240 T242 C244 C247 H248 F253 E254 R264 A267 W268 CFEPPPATTTQTGFRGLSMGEVLHPATVKAKKERDAQYPPALAAVKAEGPPVSQVYKNVKVLGNLTEAEFLRTMTAITEWVSPQEGCTYCHDENNLASEAKYPYVVARRMLEMTRAINTNWTQHVAQTGVTCYTCHRGTPLPPYVRYLEPTLPLNNRETPTHVERVETRSGYVVRLAKYTAYSALNYDPFTMFLANDKRQVRVVPQTALPLVGVSRGKERRPLSDAYATFALMMSISDSLGTNCTFCHNAQTFESWGKKSTPQRAIAWWGIRMVRDLNMNYLAPLNASLPASRLGRQGEAPQADCRTCHQGVTKPLFGASRLKDYPELGPIK 5m7j A 3.50 BS04 HEC A 4 H124 V125 T128 G129 L240 Q263 I266 A267 G270 I271 M273 V274 L277 D304 C305 C308 H309 T313 K314 P315 H124 V125 T128 G129 L240 Q263 I266 A267 G270 I271 M273 V274 L277 D304 C305 C308 H309 T313 K314 P315 CFEPPPATTTQTGFRGLSMGEVLHPATVKAKKERDAQYPPALAAVKAEGPPVSQVYKNVKVLGNLTEAEFLRTMTAITEWVSPQEGCTYCHDENNLASEAKYPYVVARRMLEMTRAINTNWTQHVAQTGVTCYTCHRGTPLPPYVRYLEPTLPLNNRETPTHVERVETRSGYVVRLAKYTAYSALNYDPFTMFLANDKRQVRVVPQTALPLVGVSRGKERRPLSDAYATFALMMSISDSLGTNCTFCHNAQTFESWGKKSTPQRAIAWWGIRMVRDLNMNYLAPLNASLPASRLGRQGEAPQADCRTCHQGVTKPLFGASRLKDYPELGPIK 5m7j B 3.50 BS02 BCL B 2 F97 P124 M127 F128 V157 N158 F160 Y162 W167 H168 H173 S176 V177 L180 F181 I240 F241 G244 T248 F97 P124 M127 F128 V157 N158 F160 Y162 W167 H168 H173 S176 V177 L180 F181 I240 F241 G244 T248 ALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLIGYAASQGPTWDPFAISINPPDLKYGLGAAPLLEGGFWQAITVCALGAFISWMLREVEISRKLGIGWHVPLAFCVPIFMFCVLQVFRPLLLGSWGHAFPYGILSHLDWVNNFGYQYLNWHYNPGHMSSVSFLFVNAMALGLHGGLILSVANPGDGDKVKTAEHENQYFRDVVGYSIGALSIHRLGLFLASNIFLTGAFGTIASGPFWTRGWPEWWGWWLDIPFWS 5m7j B 3.50 BS04 BPB B 1 I42 I49 A96 F97 W100 E104 V117 F121 P124 Y148 G149 I150 H153 A237 F241 I42 I49 A96 F97 W100 E104 V117 F121 P124 Y148 G149 I150 H153 A237 F241 ALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLIGYAASQGPTWDPFAISINPPDLKYGLGAAPLLEGGFWQAITVCALGAFISWMLREVEISRKLGIGWHVPLAFCVPIFMFCVLQVFRPLLLGSWGHAFPYGILSHLDWVNNFGYQYLNWHYNPGHMSSVSFLFVNAMALGLHGGLILSVANPGDGDKVKTAEHENQYFRDVVGYSIGALSIHRLGLFLASNIFLTGAFGTIASGPFWTRGWPEWWGWWLDIPFWS 5m7j B 3.50 BS05 MPG B 1 W115 H116 L119 S238 W115 H116 L119 S238 ALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLIGYAASQGPTWDPFAISINPPDLKYGLGAAPLLEGGFWQAITVCALGAFISWMLREVEISRKLGIGWHVPLAFCVPIFMFCVLQVFRPLLLGSWGHAFPYGILSHLDWVNNFGYQYLNWHYNPGHMSSVSFLFVNAMALGLHGGLILSVANPGDGDKVKTAEHENQYFRDVVGYSIGALSIHRLGLFLASNIFLTGAFGTIASGPFWTRGWPEWWGWWLDIPFWS 5m7j B 3.50 BS06 MPG B 2 F179 V182 H190 L193 F216 S223 I224 I229 F235 F179 V182 H190 L193 F216 S223 I224 I229 F235 ALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLIGYAASQGPTWDPFAISINPPDLKYGLGAAPLLEGGFWQAITVCALGAFISWMLREVEISRKLGIGWHVPLAFCVPIFMFCVLQVFRPLLLGSWGHAFPYGILSHLDWVNNFGYQYLNWHYNPGHMSSVSFLFVNAMALGLHGGLILSVANPGDGDKVKTAEHENQYFRDVVGYSIGALSIHRLGLFLASNIFLTGAFGTIASGPFWTRGWPEWWGWWLDIPFWS 5m7j B 3.50 BS10 MQ7 C 1 Y29 I39 W100 R103 Y29 I39 W100 R103 ALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLIGYAASQGPTWDPFAISINPPDLKYGLGAAPLLEGGFWQAITVCALGAFISWMLREVEISRKLGIGWHVPLAFCVPIFMFCVLQVFRPLLLGSWGHAFPYGILSHLDWVNNFGYQYLNWHYNPGHMSSVSFLFVNAMALGLHGGLILSVANPGDGDKVKTAEHENQYFRDVVGYSIGALSIHRLGLFLASNIFLTGAFGTIASGPFWTRGWPEWWGWWLDIPFWS 5m7j C 3.50 BS04 MPG B 1 A1 I6 A1 I6 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7j C 3.50 BS06 BCL C 1 I66 I69 M120 L124 F148 A151 F154 V155 L184 T185 F187 F194 Y195 H200 S203 I204 A207 Y208 M275 A278 I282 I66 I69 M120 L124 F148 A151 F154 V155 L184 T185 F187 F194 Y195 H200 S203 I204 A207 Y208 M275 A278 I282 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7j C 3.50 BS07 BPB C 1 F59 S63 I66 S123 L124 W127 I144 N147 F148 S271 M275 F59 S63 I66 S123 L124 W127 I144 N147 F148 S271 M275 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7j C 3.50 BS08 MQ7 C 1 H217 T220 A246 A247 W250 I254 F256 N257 A258 T259 V263 W266 H217 T220 A246 A247 W250 I254 F256 N257 A258 T259 V263 W266 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7j C 3.50 BS09 NS5 C 1 I66 L70 F88 G117 T121 G159 C160 F175 G176 I177 I66 L70 F88 G117 T121 G159 C160 F175 G176 I177 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7j C 3.50 BS10 OTP C 1 P198 G201 F206 W295 C296 P198 G201 F206 W295 C296 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7j D 3.50 BS01 OTP C 1 W17 W25 L29 W16 W24 L28 YHGALAQHLDIAQLVWYAQWLVIWTVVLLYLRREDRREGYPLVEELPYPKTFVLPHGGTVTVPRRRPETRELKLAQTDGFEGAPLQPTGNPLVDAVGPASYAERAEVVDATVDGKAKIVPLRVATDFSIAEGDVDPRGLPVVAADGVEAGTVTDLWVDRSEHYFRYLELSVAGSARTALIPLGFCDVKKDKIVVTSILSEQFANVPRLQSRDQITLREEDKVSAYYAGGLLYATPERAESLL 5m7k B 3.50 BS01 BCL B 1 M174 V177 S178 F181 V182 M185 M174 V177 S178 F181 V182 M185 ALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLIGYAASQGPTWDPFAISINPPDLKYGLGAAPLLEGGFWQAITVCALGAFISWMLREVEISRKLGIGWHVPLAFCVPIFMFCVLQVFRPLLLGSWGHAFPYGILSHLDWVNNFGYQYLNWHYNPGHMSSVSFLFVNAMALGLHGGLILSVANPGDGDKVKTAEHENQYFRDVVGYSIGALSIHRLGLFLASNIFLTGAFGTIASGPFWTRGWPEWWGWWLDIPFWS 5m7k C 3.50 BS01 BCL B 1 M120 F154 V155 I158 I177 W178 H180 W183 L184 M120 F154 V155 I158 I177 W178 H180 W183 L184 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7k C 3.50 BS05 BCL C 1 I66 I69 M120 L124 F148 A151 F154 V155 L184 T185 F187 F194 Y195 H200 S203 I204 Y208 A278 I282 I66 I69 M120 L124 F148 A151 F154 V155 L184 T185 F187 F194 Y195 H200 S203 I204 Y208 A278 I282 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7l A 3.60 BS01 HEC A 1 Y56 K57 N58 V59 K60 V61 L62 F70 M74 I77 T78 C87 C90 H91 L96 Y104 A107 R108 Y56 K57 N58 V59 K60 V61 L62 F70 M74 I77 T78 C87 C90 H91 L96 Y104 A107 R108 CFEPPPATTTQTGFRGLSMGEVLHPATVKAKKERDAQYPPALAAVKAEGPPVSQVYKNVKVLGNLTEAEFLRTMTAITEWVSPQEGCTYCHDENNLASEAKYPYVVARRMLEMTRAINTNWTQHVAQTGVTCYTCHRGTPLPPYVRYLEPTLPLNNRETPTHVERVETRSGYVVRLAKYTAYSALNYDPFTMFLANDKRQVRVVPQTALPLVGVSRGKERRPLSDAYATFALMMSISDSLGTNCTFCHNAQTFESWGKKSTPQRAIAWWGIRMVRDLNMNYLAPLNASLPASRLGRQGEAPQADCRTCHQGVTKPLFGASRLKDYPELGPIK 5m7l A 3.60 BS03 HEC A 3 R202 V203 V204 F230 M233 M234 I236 S237 L240 C244 C247 H248 F253 R264 A267 W268 R272 R202 V203 V204 F230 M233 M234 I236 S237 L240 C244 C247 H248 F253 R264 A267 W268 R272 CFEPPPATTTQTGFRGLSMGEVLHPATVKAKKERDAQYPPALAAVKAEGPPVSQVYKNVKVLGNLTEAEFLRTMTAITEWVSPQEGCTYCHDENNLASEAKYPYVVARRMLEMTRAINTNWTQHVAQTGVTCYTCHRGTPLPPYVRYLEPTLPLNNRETPTHVERVETRSGYVVRLAKYTAYSALNYDPFTMFLANDKRQVRVVPQTALPLVGVSRGKERRPLSDAYATFALMMSISDSLGTNCTFCHNAQTFESWGKKSTPQRAIAWWGIRMVRDLNMNYLAPLNASLPASRLGRQGEAPQADCRTCHQGVTKPLFGASRLKDYPELGPIK 5m7l A 3.60 BS04 HEC A 4 H124 T128 G129 V130 L240 Q263 I266 A267 G270 I271 M273 V274 L277 D304 C305 C308 H309 T313 K314 P315 H124 T128 G129 V130 L240 Q263 I266 A267 G270 I271 M273 V274 L277 D304 C305 C308 H309 T313 K314 P315 CFEPPPATTTQTGFRGLSMGEVLHPATVKAKKERDAQYPPALAAVKAEGPPVSQVYKNVKVLGNLTEAEFLRTMTAITEWVSPQEGCTYCHDENNLASEAKYPYVVARRMLEMTRAINTNWTQHVAQTGVTCYTCHRGTPLPPYVRYLEPTLPLNNRETPTHVERVETRSGYVVRLAKYTAYSALNYDPFTMFLANDKRQVRVVPQTALPLVGVSRGKERRPLSDAYATFALMMSISDSLGTNCTFCHNAQTFESWGKKSTPQRAIAWWGIRMVRDLNMNYLAPLNASLPASRLGRQGEAPQADCRTCHQGVTKPLFGASRLKDYPELGPIK 5m7l B 3.60 BS02 BCL B 2 F97 P124 M127 V157 N158 F160 Y162 W167 H168 H173 S176 V177 I240 F241 G244 T248 F97 P124 M127 V157 N158 F160 Y162 W167 H168 H173 S176 V177 I240 F241 G244 T248 ALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLIGYAASQGPTWDPFAISINPPDLKYGLGAAPLLEGGFWQAITVCALGAFISWMLREVEISRKLGIGWHVPLAFCVPIFMFCVLQVFRPLLLGSWGHAFPYGILSHLDWVNNFGYQYLNWHYNPGHMSSVSFLFVNAMALGLHGGLILSVANPGDGDKVKTAEHENQYFRDVVGYSIGALSIHRLGLFLASNIFLTGAFGTIASGPFWTRGWPEWWGWWLDIPFWS 5m7l B 3.60 BS03 BCL B 3 V46 F128 F146 I150 H153 L154 V157 V46 F128 F146 I150 H153 L154 V157 ALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLIGYAASQGPTWDPFAISINPPDLKYGLGAAPLLEGGFWQAITVCALGAFISWMLREVEISRKLGIGWHVPLAFCVPIFMFCVLQVFRPLLLGSWGHAFPYGILSHLDWVNNFGYQYLNWHYNPGHMSSVSFLFVNAMALGLHGGLILSVANPGDGDKVKTAEHENQYFRDVVGYSIGALSIHRLGLFLASNIFLTGAFGTIASGPFWTRGWPEWWGWWLDIPFWS 5m7l B 3.60 BS04 BPB B 1 I42 I49 A93 A96 F97 W100 E104 V117 A120 F121 P124 F146 Y148 G149 I150 H153 A237 F241 I42 I49 A93 A96 F97 W100 E104 V117 A120 F121 P124 F146 Y148 G149 I150 H153 A237 F241 ALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLIGYAASQGPTWDPFAISINPPDLKYGLGAAPLLEGGFWQAITVCALGAFISWMLREVEISRKLGIGWHVPLAFCVPIFMFCVLQVFRPLLLGSWGHAFPYGILSHLDWVNNFGYQYLNWHYNPGHMSSVSFLFVNAMALGLHGGLILSVANPGDGDKVKTAEHENQYFRDVVGYSIGALSIHRLGLFLASNIFLTGAFGTIASGPFWTRGWPEWWGWWLDIPFWS 5m7l B 3.60 BS06 MPG B 2 F179 V182 M185 H190 L193 F216 S223 I224 G225 I229 N239 F179 V182 M185 H190 L193 F216 S223 I224 G225 I229 N239 ALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLIGYAASQGPTWDPFAISINPPDLKYGLGAAPLLEGGFWQAITVCALGAFISWMLREVEISRKLGIGWHVPLAFCVPIFMFCVLQVFRPLLLGSWGHAFPYGILSHLDWVNNFGYQYLNWHYNPGHMSSVSFLFVNAMALGLHGGLILSVANPGDGDKVKTAEHENQYFRDVVGYSIGALSIHRLGLFLASNIFLTGAFGTIASGPFWTRGWPEWWGWWLDIPFWS 5m7l B 3.60 BS10 MQ7 C 1 V26 Y29 F30 I39 W100 R103 V26 Y29 F30 I39 W100 R103 ALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLIGYAASQGPTWDPFAISINPPDLKYGLGAAPLLEGGFWQAITVCALGAFISWMLREVEISRKLGIGWHVPLAFCVPIFMFCVLQVFRPLLLGSWGHAFPYGILSHLDWVNNFGYQYLNWHYNPGHMSSVSFLFVNAMALGLHGGLILSVANPGDGDKVKTAEHENQYFRDVVGYSIGALSIHRLGLFLASNIFLTGAFGTIASGPFWTRGWPEWWGWWLDIPFWS 5m7l C 3.60 BS01 BCL B 1 M120 V155 I158 V173 I177 H180 I181 L184 M120 V155 I158 V173 I177 H180 I181 L184 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7l C 3.60 BS05 MPG B 1 A1 D2 T5 I6 A1 D2 T5 I6 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7l C 3.60 BS06 BCL C 1 I66 M120 F148 A151 F154 V155 L184 T185 F187 F194 Y195 H200 S203 I204 Y208 M275 A278 I282 I66 M120 F148 A151 F154 V155 L184 T185 F187 F194 Y195 H200 S203 I204 Y208 M275 A278 I282 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7l C 3.60 BS07 BPB C 1 A58 F59 S63 I66 L67 L70 S123 L124 W127 I144 N147 F148 S271 M275 A58 F59 S63 I66 L67 L70 S123 L124 W127 I144 N147 F148 S271 M275 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7l C 3.60 BS09 MQ7 C 1 H217 T220 V243 A246 A247 W250 I254 F256 N257 A258 T259 I260 V263 W266 H217 T220 V243 A246 A247 W250 I254 F256 N257 A258 T259 I260 V263 W266 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7l C 3.60 BS10 NS5 C 1 L70 M73 F88 L114 G117 T121 I158 G159 C160 V173 F175 G176 I177 H180 L70 M73 F88 L114 G117 T121 I158 G159 C160 V173 F175 G176 I177 H180 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7l C 3.60 BS11 OTP C 1 P198 G201 F206 W295 C296 A301 P198 G201 F206 W295 C296 A301 ADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPIYLGASGIAAFAFGSTAILIILFNMAAEVHFDPLQFFRQFFWLGLYPPKAQYGMGIPPLHDGGWWLMAGLFMTLSLGSWWIRVYSRARALGLGTHIAWNFAAAIFFVLCIGCIHPTLVGSWSEGVPFGIWPHIDWLTAFSIRYGNFYYCPWHGFSIGFAYGCGLLFAAHGATILAVARFGGDREIEQITDRGTAVERAALFWRWTIGFNATIESVHRWGWFFSLMVMVSASVGILLTGTFVDNWYLWCVKHGAAPDYPAYLPATPDPASLPGAPK 5m7l D 3.60 BS01 OTP C 1 Q14 W17 W25 Q13 W16 W24 YHGALAQHLDIAQLVWYAQWLVIWTVVLLYLRREDRREGYPLVEELPYPKTFVLPHGGTVTVPRRRPETRELKLAQTDGFEGAPLQPTGNPLVDAVGPASYAERAEVVDATVDGKAKIVPLRVATDFSIAEGDVDPRGLPVVAADGVEAGTVTDLWVDRSEHYFRYLELSVAGSARTALIPLGFCDVKKDKIVVTSILSEQFANVPRLQSRDQITLREEDKVSAYYAGGLLYATPERAESLL 5mac A 2.60 BS01 CAP A 1 I165 K167 K169 K193 D195 E196 H288 R289 H322 K330 S399 G400 G401 G424 S425 I165 K167 K169 K193 D195 E196 H288 R289 H322 K330 S399 G400 G401 G424 S425 4.1.1.39 MSLIYEDLVKSLDSKQQAYVDLKLPDPTNGEFLLAVFHMIPGGDLNVLQAAAEIAAESSTGTNIKVSTETAFSRTMNARVYQLDLERELVWIAYPWRLFDRGGNVQNILTYIIGNILGMKEIQALKLMDIWFPPSMLEQYDGPSYTVDDMRKYLDVYDRPILGTIVKPKMGLTSAEYAEVCYDFWVGGGDFVKNDEPQANQDFCPYEKMVAHVKEAMDKAVKETGQKKVHSFNVSAADFDTMIERCEMITNAGFEPGSYAFLIDGITAGWMAVQTLRRRYPDVFLHFHRAAHGAFTRQENPIGFSVLVLSKFARLAGASGIHTGTAGIGKMKGTPAEDVVAAHSIQYLKSPGHFFEQTWSKIMDTDKDVINLVNEDLAHHVILEDDSWRAMKKCCPIVSGGLNPVKLKPFIDVMENVDFITTMGSGVHSHPGGTQSGAKALVQACDAYLQGMDIEEYAKDHKELAEAIEFYLN 5mac A 2.60 BS02 MG A 1 K193 D195 E196 K193 D195 E196 4.1.1.39 MSLIYEDLVKSLDSKQQAYVDLKLPDPTNGEFLLAVFHMIPGGDLNVLQAAAEIAAESSTGTNIKVSTETAFSRTMNARVYQLDLERELVWIAYPWRLFDRGGNVQNILTYIIGNILGMKEIQALKLMDIWFPPSMLEQYDGPSYTVDDMRKYLDVYDRPILGTIVKPKMGLTSAEYAEVCYDFWVGGGDFVKNDEPQANQDFCPYEKMVAHVKEAMDKAVKETGQKKVHSFNVSAADFDTMIERCEMITNAGFEPGSYAFLIDGITAGWMAVQTLRRRYPDVFLHFHRAAHGAFTRQENPIGFSVLVLSKFARLAGASGIHTGTAGIGKMKGTPAEDVVAAHSIQYLKSPGHFFEQTWSKIMDTDKDVINLVNEDLAHHVILEDDSWRAMKKCCPIVSGGLNPVKLKPFIDVMENVDFITTMGSGVHSHPGGTQSGAKALVQACDAYLQGMDIEEYAKDHKELAEAIEFYLN 5mac A 2.60 BS03 MG A 2 D366 D368 D366 D368 4.1.1.39 MSLIYEDLVKSLDSKQQAYVDLKLPDPTNGEFLLAVFHMIPGGDLNVLQAAAEIAAESSTGTNIKVSTETAFSRTMNARVYQLDLERELVWIAYPWRLFDRGGNVQNILTYIIGNILGMKEIQALKLMDIWFPPSMLEQYDGPSYTVDDMRKYLDVYDRPILGTIVKPKMGLTSAEYAEVCYDFWVGGGDFVKNDEPQANQDFCPYEKMVAHVKEAMDKAVKETGQKKVHSFNVSAADFDTMIERCEMITNAGFEPGSYAFLIDGITAGWMAVQTLRRRYPDVFLHFHRAAHGAFTRQENPIGFSVLVLSKFARLAGASGIHTGTAGIGKMKGTPAEDVVAAHSIQYLKSPGHFFEQTWSKIMDTDKDVINLVNEDLAHHVILEDDSWRAMKKCCPIVSGGLNPVKLKPFIDVMENVDFITTMGSGVHSHPGGTQSGAKALVQACDAYLQGMDIEEYAKDHKELAEAIEFYLN 5mac A 2.60 BS04 CAP B 1 E57 T62 N115 E57 T62 N115 4.1.1.39 MSLIYEDLVKSLDSKQQAYVDLKLPDPTNGEFLLAVFHMIPGGDLNVLQAAAEIAAESSTGTNIKVSTETAFSRTMNARVYQLDLERELVWIAYPWRLFDRGGNVQNILTYIIGNILGMKEIQALKLMDIWFPPSMLEQYDGPSYTVDDMRKYLDVYDRPILGTIVKPKMGLTSAEYAEVCYDFWVGGGDFVKNDEPQANQDFCPYEKMVAHVKEAMDKAVKETGQKKVHSFNVSAADFDTMIERCEMITNAGFEPGSYAFLIDGITAGWMAVQTLRRRYPDVFLHFHRAAHGAFTRQENPIGFSVLVLSKFARLAGASGIHTGTAGIGKMKGTPAEDVVAAHSIQYLKSPGHFFEQTWSKIMDTDKDVINLVNEDLAHHVILEDDSWRAMKKCCPIVSGGLNPVKLKPFIDVMENVDFITTMGSGVHSHPGGTQSGAKALVQACDAYLQGMDIEEYAKDHKELAEAIEFYLN 5mac A 2.60 BS05 MG C 1 E179 D183 E179 D183 4.1.1.39 MSLIYEDLVKSLDSKQQAYVDLKLPDPTNGEFLLAVFHMIPGGDLNVLQAAAEIAAESSTGTNIKVSTETAFSRTMNARVYQLDLERELVWIAYPWRLFDRGGNVQNILTYIIGNILGMKEIQALKLMDIWFPPSMLEQYDGPSYTVDDMRKYLDVYDRPILGTIVKPKMGLTSAEYAEVCYDFWVGGGDFVKNDEPQANQDFCPYEKMVAHVKEAMDKAVKETGQKKVHSFNVSAADFDTMIERCEMITNAGFEPGSYAFLIDGITAGWMAVQTLRRRYPDVFLHFHRAAHGAFTRQENPIGFSVLVLSKFARLAGASGIHTGTAGIGKMKGTPAEDVVAAHSIQYLKSPGHFFEQTWSKIMDTDKDVINLVNEDLAHHVILEDDSWRAMKKCCPIVSGGLNPVKLKPFIDVMENVDFITTMGSGVHSHPGGTQSGAKALVQACDAYLQGMDIEEYAKDHKELAEAIEFYLN 5mac B 2.60 BS01 CAP A 1 T62 N115 T62 N115 4.1.1.39 MSLIYEDLVKSLDSKQQAYVDLKLPDPTNGEFLLAVFHMIPGGDLNVLQAAAEIAAESSTGTNIKVSTETAFSRTMNARVYQLDLERELVWIAYPWRLFDRGGNVQNILTYIIGNILGMKEIQALKLMDIWFPPSMLEQYDGPSYTVDDMRKYLDVYDRPILGTIVKPKMGLTSAEYAEVCYDFWVGGGDFVKNDEPQANQDFCPYEKMVAHVKEAMDKAVKETGQKKVHSFNVSAADFDTMIERCEMITNAGFEPGSYAFLIDGITAGWMAVQTLRRRYPDVFLHFHRAAHGAFTRQENPIGFSVLVLSKFARLAGASGIHTGTAGIGKMKGTPAEDVVAAHSIQYLKSPGHFFEQTWSKIMDTDKDVINLVNEDLAHHVILEDDSWRAMKKCCPIVSGGLNPVKLKPFIDVMENVDFITTMGSGVHSHPGGTQSGAKALVQACDAYLQGMDIEEYAKDHKELAEAIEFYLN 5mac B 2.60 BS02 CAP B 1 I165 K167 K169 K193 D195 E196 H288 R289 H322 K330 M331 S399 G400 G401 M423 G424 S425 I165 K167 K169 K193 D195 E196 H288 R289 H322 K330 M331 S399 G400 G401 M423 G424 S425 4.1.1.39 MSLIYEDLVKSLDSKQQAYVDLKLPDPTNGEFLLAVFHMIPGGDLNVLQAAAEIAAESSTGTNIKVSTETAFSRTMNARVYQLDLERELVWIAYPWRLFDRGGNVQNILTYIIGNILGMKEIQALKLMDIWFPPSMLEQYDGPSYTVDDMRKYLDVYDRPILGTIVKPKMGLTSAEYAEVCYDFWVGGGDFVKNDEPQANQDFCPYEKMVAHVKEAMDKAVKETGQKKVHSFNVSAADFDTMIERCEMITNAGFEPGSYAFLIDGITAGWMAVQTLRRRYPDVFLHFHRAAHGAFTRQENPIGFSVLVLSKFARLAGASGIHTGTAGIGKMKGTPAEDVVAAHSIQYLKSPGHFFEQTWSKIMDTDKDVINLVNEDLAHHVILEDDSWRAMKKCCPIVSGGLNPVKLKPFIDVMENVDFITTMGSGVHSHPGGTQSGAKALVQACDAYLQGMDIEEYAKDHKELAEAIEFYLN 5mac B 2.60 BS03 MG B 1 K169 K193 D195 E196 K169 K193 D195 E196 4.1.1.39 MSLIYEDLVKSLDSKQQAYVDLKLPDPTNGEFLLAVFHMIPGGDLNVLQAAAEIAAESSTGTNIKVSTETAFSRTMNARVYQLDLERELVWIAYPWRLFDRGGNVQNILTYIIGNILGMKEIQALKLMDIWFPPSMLEQYDGPSYTVDDMRKYLDVYDRPILGTIVKPKMGLTSAEYAEVCYDFWVGGGDFVKNDEPQANQDFCPYEKMVAHVKEAMDKAVKETGQKKVHSFNVSAADFDTMIERCEMITNAGFEPGSYAFLIDGITAGWMAVQTLRRRYPDVFLHFHRAAHGAFTRQENPIGFSVLVLSKFARLAGASGIHTGTAGIGKMKGTPAEDVVAAHSIQYLKSPGHFFEQTWSKIMDTDKDVINLVNEDLAHHVILEDDSWRAMKKCCPIVSGGLNPVKLKPFIDVMENVDFITTMGSGVHSHPGGTQSGAKALVQACDAYLQGMDIEEYAKDHKELAEAIEFYLN 5mat A 2.07 BS02 7KJ A 1 I93 P94 F96 F119 A135 L138 Y139 F143 I169 D170 T171 F190 I213 V233 F235 I39 P40 F42 F63 A79 L82 Y83 F87 I113 D114 T115 F134 I157 V177 F179 3.5.1.- 28135086 MERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQS 5mc9 A 2.13 BS01 CA A 1 D2173 L2190 V2247 D2249 D91 L108 V165 D167 28132784 EMQANLLLDRLKPLKTLEENLSRNLSEIKLLISRARKQAASIKVAVSADRDCIRAYQPQTSSTNYNTLILNVKTQEPDNLLFYLGSSSSSDFLAVEMRRGKVAFLWDLGSGSTRLEFPEVSINNNRWHSIYITRFGNMGSLSVKEASAAENPPVRTSKSPGPSKVLDINNSTLMFVGGLGGQIKKSPAVKVTHFKGCMGEAFLNGKSIGLWNYIEREGKCNGCFGSSQNEDSSFHFDGSGYAMVEKTLRPTVTQIVILFSTFSPNGLLFYLASNGTKDFLSIELVRGRVKVMVDLGSGPLTLMTDRRYNNGTWYKIAFQRNRKQGLLAVFDAYDTSDKETKQGETPGAASDLNRLEKDLIYVGGLPHSKAVRKGVSSRSYVGCIKNLEISRSTFDLLRNSYGVRKGCALEPIQSVSFLRGGYVEMPPKSLSPESSLLATFATKNSSGILLVALGKDAHVPFFSIMLLEGRIEVHVNSGDGTSLRKALLHAPTGSYSDGQEHSISLVRNRRVITIQVDENSPVEMKLGPLTEGKTIDISNLYIGGLPEDKATPMLKMRTSFHGCIKNVVLDAQLLDFTHATGSEQVELDTCLLAEEPM 5mc9 A 2.13 BS02 CA A 2 D2360 L2377 D2433 N2435 D278 L295 D351 N353 28132784 EMQANLLLDRLKPLKTLEENLSRNLSEIKLLISRARKQAASIKVAVSADRDCIRAYQPQTSSTNYNTLILNVKTQEPDNLLFYLGSSSSSDFLAVEMRRGKVAFLWDLGSGSTRLEFPEVSINNNRWHSIYITRFGNMGSLSVKEASAAENPPVRTSKSPGPSKVLDINNSTLMFVGGLGGQIKKSPAVKVTHFKGCMGEAFLNGKSIGLWNYIEREGKCNGCFGSSQNEDSSFHFDGSGYAMVEKTLRPTVTQIVILFSTFSPNGLLFYLASNGTKDFLSIELVRGRVKVMVDLGSGPLTLMTDRRYNNGTWYKIAFQRNRKQGLLAVFDAYDTSDKETKQGETPGAASDLNRLEKDLIYVGGLPHSKAVRKGVSSRSYVGCIKNLEISRSTFDLLRNSYGVRKGCALEPIQSVSFLRGGYVEMPPKSLSPESSLLATFATKNSSGILLVALGKDAHVPFFSIMLLEGRIEVHVNSGDGTSLRKALLHAPTGSYSDGQEHSISLVRNRRVITIQVDENSPVEMKLGPLTEGKTIDISNLYIGGLPEDKATPMLKMRTSFHGCIKNVVLDAQLLDFTHATGSEQVELDTCLLAEEPM 5msg A 3.80 BS02 NUC V 1 K330 A365 T366 G367 D368 G369 L370 T371 Y372 K374 P391 K392 I393 P394 H506 V513 T515 R558 V559 N560 G561 Q566 N692 K324 A359 T360 G361 D362 G363 L364 T365 Y366 K368 P385 K386 I387 P388 H500 V507 T509 R552 V553 N554 G555 Q560 N686 28126917 SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVISDMNFLDEEGKAYTAQNLRPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYLADLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSNESSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDVEKGIDFKLGQTISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKLTWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAKECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQKTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEMNLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKYVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHLRGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYCRVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGDRVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAESRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWLGFEKEGSKVLESVDEI 5msg B 3.80 BS01 NUC R 1 G35 G125 R126 Q127 N136 M227 T228 K229 D230 I241 A242 T243 R249 M410 M412 N414 P650 R669 N670 R671 S672 I673 L674 N675 T676 G36 G126 R127 Q128 N137 M228 T229 K230 D231 I242 A243 T244 R250 M411 M413 N415 P647 R666 N667 R668 S669 I670 L671 N672 T673 2.7.7.48 28126917 GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEYSNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEHPGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITSFRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAKNRKGFLIKRIPMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRGFVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISMTVTGDNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIARLGKGFMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEEGTASLSPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALFVNAKDEETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDGFVSNFAMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLFIADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNLRNLHIPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSIEGIKEADITPVKKMDYDAVSGTHSWRTKRNRSILNTDQRNMILEEQCYAKCCNLFEACFNSASYRKPVGQHSMLEAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEI 5msg B 3.80 BS02 NUC V 1 H32 G33 T34 Y38 M356 K365 E384 N675 H33 G34 T35 Y39 M357 K366 E385 N672 2.7.7.48 28126917 GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEYSNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEHPGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITSFRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAKNRKGFLIKRIPMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRGFVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISMTVTGDNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIARLGKGFMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEEGTASLSPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALFVNAKDEETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDGFVSNFAMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLFIADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNLRNLHIPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSIEGIKEADITPVKKMDYDAVSGTHSWRTKRNRSILNTDQRNMILEEQCYAKCCNLFEACFNSASYRKPVGQHSMLEAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEI 5msg C 3.80 BS01 NUC M 1 R217 E255 S258 Q259 I262 R266 G306 Q325 R326 F327 G328 R334 G339 K341 W359 E363 K378 F406 M433 Y434 Q435 R438 S520 L522 S524 R218 E256 S259 Q260 I263 R267 G307 Q326 R327 F328 G329 R335 G340 K342 W360 E364 K379 F407 M434 Y435 Q436 R439 S511 L513 S515 28126917 GMTLAKIELLKQLLRDNEAKTVLKQTTVDQYNIIRKFNTSRIEKNPSLRMKWAMCSNFPLALTKGDMANRIPLEYKGIQLKTNAEDIGTKGQMCSIAAVTWWNTYGPIGDTEGFERVYESFFLRKMRLDNATWGRITFGPVERVRKRVLLNPLTKEMPPDEASNVIMEILFPKEAGIPRESTWIHRELIKEKREKLKGTMITPIVLAYMLERELVARRRFLPVAGATSAEFIEMLHCLQGENWRQIYHPGGNKLTESRSQSMIVACRKIIRRSIVASNPLELAVEIANKTVIDTEPLKSCLAAIDGGDVACDIIRAALGLKIRQRQRFGRLELKRISGRGFKNDEEILIGNGTIQKIGIWDGEEEFHVRCGECRGILKKSKMKLEKLLINSAKKEDMRDLIILCMVFSQDTRMFQGVRGEINFLNRAGQLLSPMYQLQRYFLNRSNDLFDQWGYEESPKASELHGINESMNASDYTLKGVVVTRNVKVSITKNLSLIKRTGEVIMGANDVSELESQAQLMITYDTPKMWEMGTTKELVQNTYQWVLKNLVTLKAQFLLGKEDMFQWDAFEAFESIIPQKMAGQYSGFARAVLKQMRDQEVMKTDQFIKLLPFCFSPPKLRSNGEPYQFLKLVLKGGGENFIEVRKGSPLFSYNPQTEVLTICGRMMSLKGKIEDEERNRSMGNAVLAGFLVSGKYDPDLGDFKTIEELEKLKPGEKANILLYQGKPVKVVK 5msg C 3.80 BS02 NUC R 1 T38 S39 R40 E42 K43 R48 W51 T39 S40 R41 E43 K44 R49 W52 28126917 GMTLAKIELLKQLLRDNEAKTVLKQTTVDQYNIIRKFNTSRIEKNPSLRMKWAMCSNFPLALTKGDMANRIPLEYKGIQLKTNAEDIGTKGQMCSIAAVTWWNTYGPIGDTEGFERVYESFFLRKMRLDNATWGRITFGPVERVRKRVLLNPLTKEMPPDEASNVIMEILFPKEAGIPRESTWIHRELIKEKREKLKGTMITPIVLAYMLERELVARRRFLPVAGATSAEFIEMLHCLQGENWRQIYHPGGNKLTESRSQSMIVACRKIIRRSIVASNPLELAVEIANKTVIDTEPLKSCLAAIDGGDVACDIIRAALGLKIRQRQRFGRLELKRISGRGFKNDEEILIGNGTIQKIGIWDGEEEFHVRCGECRGILKKSKMKLEKLLINSAKKEDMRDLIILCMVFSQDTRMFQGVRGEINFLNRAGQLLSPMYQLQRYFLNRSNDLFDQWGYEESPKASELHGINESMNASDYTLKGVVVTRNVKVSITKNLSLIKRTGEVIMGANDVSELESQAQLMITYDTPKMWEMGTTKELVQNTYQWVLKNLVTLKAQFLLGKEDMFQWDAFEAFESIIPQKMAGQYSGFARAVLKQMRDQEVMKTDQFIKLLPFCFSPPKLRSNGEPYQFLKLVLKGGGENFIEVRKGSPLFSYNPQTEVLTICGRMMSLKGKIEDEERNRSMGNAVLAGFLVSGKYDPDLGDFKTIEELEKLKPGEKANILLYQGKPVKVVK 5sun A 2.48 BS01 NDP A 1 K72 T75 I76 T77 R82 N96 L288 H309 G310 T311 V312 T313 R314 H315 T327 N328 K70 T73 I74 T75 R80 N94 L263 H284 G285 T286 V287 T288 R289 H290 T302 N303 1.1.1.42 28132785 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAK 5sun A 2.48 BS02 70Q A 1 R109 E110 A111 W124 K126 I128 I130 A258 M259 G263 W267 R107 E108 A109 W122 K124 I126 I128 A248 M249 G253 W257 1.1.1.42 28132785 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAK 5sun B 2.48 BS01 NDP B 1 K72 T75 T77 R82 N96 H309 G310 T311 V312 T313 R314 H315 T327 N328 D375 K70 T73 T75 R80 N94 H287 G288 T289 V290 T291 R292 H293 T305 N306 D353 1.1.1.42 28132785 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHARATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 5sun B 2.48 BS02 70Q B 1 R109 E110 I113 W124 K126 I128 V255 A258 M259 G263 W267 M291 R107 E108 I111 W122 K124 I126 V248 A251 M252 G256 W260 M269 1.1.1.42 28132785 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHARATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 5svf A 2.34 BS01 NDP A 1 A74 T75 T77 R82 N96 L288 E306 H309 G310 T311 V312 T313 R314 H315 T327 N328 A71 T72 T74 R79 N93 L274 E292 H295 G296 T297 V298 T299 R300 H301 T313 N314 1.1.1.42 28132785 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 5svf A 2.34 BS02 70P A 1 R109 A111 I113 R119 L120 W124 P127 I128 I130 S278 V281 A282 Y285 S287 M291 R106 A108 I110 R116 L117 W121 P124 I125 I127 S264 V267 A268 Y271 S273 M277 1.1.1.42 28132785 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 5svf C 2.34 BS01 NDP C 1 K72 A74 T75 I76 T77 R82 N96 E306 H309 G310 T311 V312 T313 R314 H315 T327 N328 K69 A71 T72 I73 T74 R79 N93 E291 H294 G295 T296 V297 T298 R299 H300 T312 N313 1.1.1.42 28132785 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHARATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 5svf C 2.34 BS02 70P C 1 R109 E110 A111 R119 L120 W124 I128 I130 A282 Y285 S287 M291 R106 E107 A108 R116 L117 W121 I125 I127 A267 Y270 S272 M276 1.1.1.42 28132785 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHARATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 5svf B 2.34 BS01 NDP B 1 K72 A74 T75 T77 R82 N96 Q283 L288 H309 G310 T311 V312 T313 R314 H315 T327 N328 D375 K70 A72 T73 T75 R80 N94 Q268 L273 H294 G295 T296 V297 T298 R299 H300 T312 N313 D360 1.1.1.42 28132785 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 5svf B 2.34 BS02 70P B 1 R109 A111 I113 R119 L120 W124 I128 I130 V281 A282 Y285 S287 M291 R107 A109 I111 R117 L118 W122 I126 I128 V266 A267 Y270 S272 M276 1.1.1.42 28132785 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQA 5svf D 2.34 BS02 70P D 1 R109 E110 A111 I113 R119 L120 W124 P127 I128 I130 A282 Y285 S287 M291 R106 E107 A108 I110 R116 L117 W121 P124 I125 I127 A274 Y277 S279 M283 1.1.1.42 28132785 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLA 5svn A 2.10 BS01 NDP A 1 K112 A114 T115 I116 T117 R122 N136 L327 H348 G349 T350 V351 T352 R353 H354 N367 D414 K70 A72 T73 I74 T75 R80 N94 L285 H306 G307 T308 V309 T310 R311 H312 N325 D372 1.1.1.42 28132785 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGKHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGFLNTTDFLDTIKSNLDRALG 5svn A 2.10 BS02 NDP B 1 L289 D292 Q296 K299 L247 D250 Q254 K257 1.1.1.42 28132785 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGKHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGFLNTTDFLDTIKSNLDRALG 5svn B 2.10 BS02 NDP B 1 K112 A114 T115 I116 T117 R122 N136 L327 H348 G349 T350 V351 T352 H354 T366 N367 K70 A72 T73 I74 T75 R80 N94 L285 H306 G307 T308 V309 T310 H312 T324 N325 1.1.1.42 28132785 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGKHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNLNEHFLNTTDFLDTIKSNLDRALGR 5svo A 1.87 BS01 NAP A 1 K112 A114 T115 T117 R122 N136 H348 G349 T350 V351 T352 R353 H354 T366 N367 D414 K71 A73 T74 T76 R81 N95 H307 G308 T309 V310 T311 R312 H313 T325 N326 D373 1.1.1.42 28132785 KRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIQNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGR 5t16 A 2.78 BS01 NUC G 1 G266 S269 T270 K371 R372 Q373 Y375 S376 G379 Y380 A381 Y387 P393 A395 R418 N419 I420 K421 R445 A446 I448 R450 S453 V454 L455 K456 G83 S86 T87 K188 R189 Q190 Y192 S193 G196 Y197 A198 Y204 P210 A212 R235 N236 I237 K238 R262 A263 I265 R267 S270 V271 L272 K273 3.1.26.3 28111020 YDPTKAGDIVKATKWPPKLPEIQDLAIRARVFIHKSTIKDKVYLSGSEMINAHNERLEFLGDSILNSVMTLIIYNKFPDYSEGQLSTLRMNLVSNEQIKQWSIMYNFHEKLKTNFDLKDENSNFQNGKLKLYADVFEAYIGGLMEDDPRNNLPKIRKWLRKLAKPVIEEATRNQVALEKTDKLDMNAKRQLYSLIGYASLRLHYVTVKKPTAVDPNSIVECRVGDGTVLGTGVGRNIKIAGIRAAENALRDKKMLDFYAKQRAAIPRSESVLKDPS 5t16 A 2.78 BS02 NUC H 1 H217 K218 K222 V225 N297 F298 N306 F307 K311 K313 H34 K35 K39 V42 N114 F115 N123 F124 K128 K130 3.1.26.3 28111020 YDPTKAGDIVKATKWPPKLPEIQDLAIRARVFIHKSTIKDKVYLSGSEMINAHNERLEFLGDSILNSVMTLIIYNKFPDYSEGQLSTLRMNLVSNEQIKQWSIMYNFHEKLKTNFDLKDENSNFQNGKLKLYADVFEAYIGGLMEDDPRNNLPKIRKWLRKLAKPVIEEATRNQVALEKTDKLDMNAKRQLYSLIGYASLRLHYVTVKKPTAVDPNSIVECRVGDGTVLGTGVGRNIKIAGIRAAENALRDKKMLDFYAKQRAAIPRSESVLKDPS 5t16 B 2.78 BS01 NUC G 1 H217 K218 K222 V225 F298 N306 F307 G310 K311 K313 H34 K35 K39 V42 F115 N123 F124 G127 K128 K130 3.1.26.3 28111020 YDPTKAGDIVKATKWPPKLPEIQDLAIRARVFIHKSTIKDKVYLSGSEMINAHNERLEFLGDSILNSVMTLIIYNKFPDYSEGQLSTLRMNLVSNEQIKQWSIMYNFHEKLKTNFDLKDENSNFQNGKLKLYADVFEAYIGGLMEDDPRNNLPKIRKWLRKLAKPVIEEATRNKTDKLDMNAKRQLYSLIGYASLRLHYVTVKKPTAVDPNSIVECRVGDGTVLGTGVGRNIKIAGIRAAENALRDKKMLDFYAKQRAAIPRSESVLKD 5t16 B 2.78 BS02 NUC H 1 T270 K371 R372 Y375 S376 G379 Y380 A381 Y387 K392 P393 A395 R418 N419 I420 K421 R445 A446 I448 R450 S453 V454 L455 K456 T87 K183 R184 Y187 S188 G191 Y192 A193 Y199 K204 P205 A207 R230 N231 I232 K233 R257 A258 I260 R262 S265 V266 L267 K268 3.1.26.3 28111020 YDPTKAGDIVKATKWPPKLPEIQDLAIRARVFIHKSTIKDKVYLSGSEMINAHNERLEFLGDSILNSVMTLIIYNKFPDYSEGQLSTLRMNLVSNEQIKQWSIMYNFHEKLKTNFDLKDENSNFQNGKLKLYADVFEAYIGGLMEDDPRNNLPKIRKWLRKLAKPVIEEATRNKTDKLDMNAKRQLYSLIGYASLRLHYVTVKKPTAVDPNSIVECRVGDGTVLGTGVGRNIKIAGIRAAENALRDKKMLDFYAKQRAAIPRSESVLKD 5t16 C 2.78 BS01 NUC G 1 I50 H54 K58 I9 H13 K17 3.1.26.3 28111020 SNYKYLEVIQLEHAVTKLVESYNKIIELSPNLVAYNEAVNNQDRVPVQILPSLSRYQLKLAAELKTLHDLKKDAILTEITDYENEFDTEQKQPILQEISKADMEKLEKLEQVK 5t16 E 2.78 BS01 NUC H 1 I50 H54 I8 H12 3.1.26.3 28111020 NYKYLEVIQLEHAVTKLVESYNKIIELSPNLVAYNEAVNNQDRVPVQILPSLSRYQLKLAAELKTLHDLKKDAILTEITDYENEFDTEQKQPILQEISKADMEKLEKLEQVKREK 5t16 J 2.78 BS01 NUC O 1 H217 K218 S219 K222 F298 N306 F307 K311 K313 H33 K34 S35 K38 F114 N122 F123 K127 K129 3.1.26.3 28111020 DPTKAGDIVKATKWPPKLPEIQDLAIRARVFIHKSTIKDKVYLSGSEMINAHNERLEFLGDSILNSVMTLIIYNKFPDYSEGQLSTLRMNLVSNEQIKQWSIMYNFHEKLKTNFDLKDENSNFQNGKLKLYADVFEAYIGGLMEDDPRNNLPKIRKWLRKLAKPVIEEATRNQVKLDMNAKRQLYSLIGYASLRLHYVTVKKPTAVDPNSIVECRVGDGTVLGTGVGRNIKIAGIRAAENALRDKKMLDFYAKQRAAIPRSESVLKD 5t4u A 1.50 BS01 12Q A 1 I652 V657 P658 Y707 N708 F714 I25 V30 P31 Y80 N81 F87 28068087 MQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVLRQARRQAEKM 5t4v A 1.65 BS01 N48 A 1 I652 V657 P658 E661 V662 C704 N708 F714 I25 V30 P31 E34 V35 C77 N81 F87 28068087 MQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVLRQARRQAEKM 5ti1 A 2.00 BS01 MG A 1 D145 Y178 E218 E220 D252 K272 D137 Y168 E208 E210 D242 K262 3.7.1.2 SSDLQATLDPSRKSWVESANNPTGDFSIQNLPFGIFSDGLNATRRVGVAIGDSIVDLAALESAGLLSVPDSVFVRDALNDFIALGRDAWRSVRVQLSRLLSRDDATLRDDAELRGRALIRQADAQLHLPVQIPGYTDFYSSKEHATNVGSMFRDNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFVIGAGNALGEPVTCADAEAHIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPAQDPQPLAYLRHDGEHAFDITLEVTLRPQQAKEASTITRTNFKHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPTEDSFGSLLELTWNGKKPLELREGGTRSFIEDGDELTLAGWCQGEGYRVGFGVCAGEILPALK 5ti1 B 2.00 BS01 MG B 1 D145 E218 E220 D252 K272 D138 E211 E213 D245 K265 3.7.1.2 SSDLQATLDPSRKSWVESANNPTGDFSIQNLPFGIFSDGLNATRRVGVAIGDSIVDLAALESAGLLSVPSDSVFVRDALNDFIALGRDAWRSVRVQLSRLLSRDDATLRDDAELRGRALIRQADAQLHLPVQIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFVIGAGNALGEPVTCADAEAHIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPAQDPQPLAYLRHDGEHAFDITLEVTLRPQQAKEASTITRTNFKHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPTEDSFGSLLELTWNGKKPLELREGGTRSFIEDGDELTLAGWCQGEGYRVGFGVCAGEILPALK 5ti1 C 2.00 BS01 MG C 1 D145 E218 E220 D252 D138 E211 E213 D245 3.7.1.2 SSDLQATLDPSRKSWVESANNPTGDFSIQNLPFGIFSDGLNATRRVGVAIGDSIVDLAALESAGLLSVPSDSVFVRDALNDFIALGRDAWRSVRVQLSRLLSRDDATLRDDAELRGRALIRQADAQLHLPVQIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFVIGAGNALGEPVTCADAEAHIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPAQDPQPLAYLRHDGEHAFDITLEVTLRPQQAKEASTITRTNFKHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPTEDSFGSLLELTWNGKKPLELREGGTRSFIEDGDELTLAGWCQGEGYRVGFGVCAGEILPALK 5tkr A 1.80 BS01 ADP A 1 G22 T23 S24 D26 G188 G189 N217 D221 Y234 D235 K236 D237 G327 G328 G329 Y331 R359 E362 G13 T14 S15 D17 G179 G180 N208 D212 Y225 D226 K227 D228 G318 G319 G320 Y322 R350 E353 2.7.-.- NVLDFTVLGLNSGTSMDGIDCALCHFYQKTPDAPMEFELLEYGEVPLAQPIKQRVMRMILEDTTSPSELSEVNVILGEHFADAVRQFAAERNVDLSTIDAIASHGQTIWLLSMPEEGQVKSALTMAEGAILASRTGITSITDFRISDQAAGRQGAPLIAFFDALLLHHPTKLRACQNIGGIANVCFIPPDVDGRRTDEYYDFDTGPGNVFIDAVVRHFTNGEQEYDKDGAMGKRGKVDQELVDDFLKMPYFQLDPPKTTGREVFRDTLAHDLIRRAEAKGLSPDDIVATTTRITAQAIVDHYRRYAPSQEIDEIFMCGGGAYNPNIVEFIQQSYPNTKIMMLDEAGVPARAKEAITFAWQGMEALVGRSIPVPTRVETRQHYVLGKVSPGLNYRSVMKKGMAFGGDAQQLPWVSEMIVKKKGKVITNNWALE 5tmh A 3.28 BS01 SAH A 1 S56 G58 G81 C82 G86 W87 K105 H110 V130 D131 V132 F133 D146 S51 G53 G76 C77 G81 W82 K100 H105 V125 D126 V127 F128 D141 ETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGHAVSRGSAKLRWLVERGYLQPYGKVVDLGCGRGGWSYYAATIRKVQEVRGYTKGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEETRTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETMERLQRRHGGGLVRVPLSRNSTHEMYWVSGAKSNIIKSVSTTSQLLLGRMDGPRRPVKYEEDVNLGSGTRAVASCAEAPNMKIIGRRIERIRNEHAETWFLDENHPYRTWAYHGSYEAPTQGSASSLVNGVVRLLSKPWDVVTGVTGIAMTDTTPYGQQRVFKEKVDTRVPDPQEGTRQVMNIVSSWLWKELGKRKRPRVCTKEEFINKVRSNAALGAIFEEEKEWKTAVEAVNDPRFWALVDREREHHLRGECHSCVYNMMGKREKKQGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVEGLGLQRLGYILEEMNRAPGGKMYADDTAGWDTRISKFDLENEALITNQMEEGHRTLALAVIKYTYQNKVVKVLRPAEGGKTVMDIISRQDQRGSGQVVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRKPEKVTRWLQSNGWDRLKRMAVSGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWSNWEEVPFCSHHFNKLYLKDGRSIVVPCRHQDELIGRARVSPGASIRETACLAKSYAQMWQLLYFHRRDLRLMANAICSAVPVDWVPTGRTTWSIHGKGEWMTTEDMLMVWNRVWIEENDHMEDKTPVTKWTDIPYLGKREDLWCGSLIGHRPRTTWAENIKDTVNMVRRIIGDEEKYMDYLS 5tmh B 3.28 BS01 SAH B 1 S56 G58 G81 C82 W87 T104 K105 H110 V130 D131 V132 F133 D146 S51 G53 G76 C77 W82 T99 K100 H105 V125 D126 V127 F128 D141 ETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGHAVSRGSAKLRWLVERGYLQPYGKVVDLGCGRGGWSYYAATIRKVQEVRGYTKGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEETRTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETMERLQRRHGGGLVRVPLSRNSTHEMYWVSGAKSNIIKSVSTTSQLLLGRMDGPRRPVKYEEDVNLGSGTRAVASCAEAPNMKIIGRRIERIRNEHAETWFLDENHPYRTWAYHGSYEAPTQGSASSLVNGVVRLLSKPWDVVTGVTGIAMTDTTPYGQQRVFKEKVDTRVPDPQEGTRQVMNIVSSWLWKELGKRKRPRVCTKEEFINKVRSNAALGAIFEEEKEWKTAVEAVNDPRFWALVDREREHHLRGECHSCVYNMMGKREKKQGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVEGLGLQRLGYILEEMNRAPGGKMYADDTAGWDTRISKFDLENEALITNQMEEGHRTLALAVIKYTYQNKVVKVLRPAEGGKTVMDIISRQDQRGSGQVVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRKPEKVTRWLQSNGWDRLKRMAVSGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWSNWEEVPFCSHHFNKLYLKDGRSIVVPCRHQDELIGRARVSPGASIRETACLAKSYAQMWQLLYFHRRDLRLMANAICSAVPVDWVPTGRTTWSIHGKGEWMTTEDMLMVWNRVWIEENDHMEDKTPVTKWTDIPYLGKREDLWCGSLIGHRPRTTWAENIKDTVNMVRRIIGDEEKYMDYLS 5ttj A 2.20 BS01 FAD A 1 V59 G60 G62 F63 A64 E83 A84 R85 G89 G90 R91 T92 F104 G105 G106 A107 W108 P278 V279 T307 V308 P309 I316 W417 F422 A426 W427 G452 A453 A461 N462 I463 A466 V9 G10 G12 F13 A14 E33 A34 R35 G39 G40 R41 T42 F54 G55 G56 A57 W58 P228 V229 T257 V258 P259 I266 W367 F372 A376 W377 G402 A403 A411 N412 I413 A416 GFDYDVVVVGGGFAGATAARECGLQGYRTLLLEARSRLGGRTFTSRFAGQEIEFGGAWVHWLQPHVWAEMQRYGLGVVEDPLTNLDKTLIMYNDGSVESISPDEFGKNIRIAFEKLCHDAWEVFPRPHEPMFTERARELDKSSVLDRIKTLGLSRLQQAQINSYMALYAGETTDKFGLPGVLKLFACGGWNYDAFMDTETHYRIQGGTIGLINAMLTDSGAEVRMSVPVTAVEQVNGGVKIKTDDDEIITAGVVVMTVPLNTYKHIGFTPALSKGKQRFIKEGQLSKGAKLYVHVKQNLGRVFAFADEQQPLNWVQTHDYSDELGTILSITIARKETIDVNDRDAVTREVQKMFPGVEVLGTAAYDWTADPFSLGAWAAYGVGQLSRLKDLQAAEGRILFAGAETSNGWHANIDGAVESGLRAGREVKQLLSL 5two A 1.93 BS01 III B 1 T297 K301 L311 N312 Q314 V315 L318 P467 L468 E471 T91 K95 L105 N106 Q108 V109 L112 P261 L262 E265 28128331 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDL 5two A 1.93 BS02 7MV A 1 I281 F282 G284 C285 Q286 R288 S289 Y327 L330 I341 F363 M364 H449 L465 L469 Y473 I75 F76 G78 C79 Q80 R82 S83 Y121 L124 I135 F157 M158 H243 L259 L263 Y267 28128331 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDL 5u08 A 1.52 BS01 SIS A 1 F35 D91 D128 Y153 F30 D86 D123 Y148 EIDNFLKIERLAENDLPKFIQLIRLFEAVFEMKNFSIPDSEHLQKLLNQNNFYVFVALLENKIVGGLTSYVLEQYYSEKPLAYIYDLAVDTNWQRQGIGKKLITATNQFYTEKGFEEVFVQADKVDDYALDFARSTKPTAEEQVVHFYYTLK 5u08 A 1.52 BS02 SIS A 2 E121 E122 E147 E116 E117 E142 EIDNFLKIERLAENDLPKFIQLIRLFEAVFEMKNFSIPDSEHLQKLLNQNNFYVFVALLENKIVGGLTSYVLEQYYSEKPLAYIYDLAVDTNWQRQGIGKKLITATNQFYTEKGFEEVFVQADKVDDYALDFARSTKPTAEEQVVHFYYTLK 5u08 B 1.52 BS01 SIS A 1 Y81 E122 E147 Y74 E115 E140 DNFLKIERLAENDLPKFIQLIRLFEAVFEMKNFSIPDSEHLQKLLNQNNFYVFVALLENKIVGGLTSYVLEQYYSEKPLAYIYDLAVDTNWQRQGIGKKLITATNQFYTEKGFEEVFVQADKVDDYALDFARSTKPTAEEQVVHFYYTLK 5u08 C 1.52 BS03 CA C 2 E18 N53 E11 N46 DNFLKIERLAENDLPKFIQLIRLFEAVFEMKNFSIPDSEHLQKLLNQNNFYVFVALLENKIVGGLTSYVLEQYYSEKPLAYIYDLAVDTNWQRQGIGKKLITATNQFYTEKGFEEVFVQADKVDDYALDFARSTKPTAEEQVVHFYYTLK 5u08 C 1.52 BS04 SIS D 1 F35 Y90 D91 D128 F28 Y83 D84 D121 DNFLKIERLAENDLPKFIQLIRLFEAVFEMKNFSIPDSEHLQKLLNQNNFYVFVALLENKIVGGLTSYVLEQYYSEKPLAYIYDLAVDTNWQRQGIGKKLITATNQFYTEKGFEEVFVQADKVDDYALDFARSTKPTAEEQVVHFYYTLK 5u17 A 2.15 BS01 7WP A 1 Y7 R9 K43 Y62 L66 W69 R94 W156 Y7 R9 K43 Y62 L66 W69 R94 W156 RTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIESNLYSCHVEHSGVHMVLQV 5u28 A 1.80 BS01 82V A 1 W81 P82 F83 Q85 V87 L92 L94 N140 I146 W39 P40 F41 Q43 V45 L50 L52 N98 I104 28137841 ANPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQA 5u2c A 3.30 BS01 82Y A 1 W374 P375 F376 V380 L385 Y390 N433 H437 W36 P37 F38 V42 L47 Y52 N95 H99 28137841 GILPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMP 5u2c B 3.30 BS01 82Y B 1 P375 V380 L385 L387 Y390 N433 H437 P27 V32 L37 L39 Y42 N85 H89 28137841 KVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPD 5u2e B 1.99 BS01 837 B 1 W81 P82 F83 V87 K91 L92 N140 I146 W41 P42 F43 V47 K51 L52 N100 I106 28137841 GSTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 5u2f B 2.53 BS01 82Y B 1 W81 P82 V87 L92 L94 N140 I146 W41 P42 V47 L52 L54 N100 I106 28137841 GSTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEI 5u2v A 2.20 BS02 7WQ A 1 Y7 K43 H58 Y62 W156 Y8 K44 H59 Y63 W157 MRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELLYSCHVEHSGVHMVLQV 5u2v C 2.20 BS01 7WQ C 1 Y7 T34 K43 H58 Y62 L66 Y8 T35 K44 H59 Y63 L67 MRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHSGVHMVLQV 5u6q C 1.90 BS01 7ZS C 1 Y7 R9 S24 K43 Y62 L66 W69 R94 Y8 R10 S25 K44 Y63 L67 W70 R95 MRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHSGVHMVLQV 5u72 C 2.50 BS01 7ZV C 1 Y7 R9 S24 K43 Y62 L65 L66 W69 I96 W156 W164 Y8 R10 S23 K42 Y61 L64 L65 W68 I95 W155 W163 MRTHSLRYFRLGVSDPIVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIEIDYGDILPSGDGTYQAWASIELDSNLYSCHVEHSGVHMVLQV 5u8t 2 4.90 BS01 NUC F 1 S579 W589 K633 A634 S347 W357 K401 A402 3.6.4.12 28096349 PNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLLGPFFQDSNEEIRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRRVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSSPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAIY 5u8t 2 4.90 BS02 ANP 2 1 I505 Y506 G507 G546 T547 A548 K549 S550 Q551 E608 L695 I273 Y274 G275 G314 T315 A316 K317 S318 Q319 E376 L463 3.6.4.12 28096349 PNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLLGPFFQDSNEEIRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRRVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSSPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAIY 5u8t 2 4.90 BS03 ANP 5 1 I533 H621 E625 R676 V807 R808 E811 I301 H389 E393 R444 V526 R527 E530 3.6.4.12 28096349 PNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLLGPFFQDSNEEIRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRRVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSSPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAIY 5u8t 3 4.90 BS01 NUC F 1 S438 A444 T447 T448 R455 K499 S369 A375 T378 T379 R386 K430 3.6.4.12 28096349 DAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHRQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALL 5u8t 3 4.90 BS02 ANP 3 1 I371 Y372 P411 S412 T413 A414 K415 S416 Q417 E474 N517 I302 Y303 P342 S343 T344 A345 K346 S347 Q348 E405 N448 3.6.4.12 28096349 DAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHRQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALL 5u8t 5 4.90 BS01 NUC F 1 S452 Q454 R455 R460 F462 A507 S364 Q366 R367 R372 F374 A419 3.6.4.12 28096349 DDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFTVSLPRSCNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAAS 5u8t 5 4.90 BS02 ANP 3 1 L406 R549 I650 R651 L318 R461 I559 R560 3.6.4.12 28096349 DDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFTVSLPRSCNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAAS 5u8t 5 4.90 BS03 ANP 5 1 I378 F379 G419 T420 A421 K422 S423 Q424 N524 I290 F291 G331 T332 A333 K334 S335 Q336 N436 3.6.4.12 28096349 DDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFTVSLPRSCNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAAS 5u8t 6 4.90 BS01 NUC F 1 S604 A611 V612 R614 K665 S362 A369 V370 R372 K423 3.6.4.12 28096349 LNHVKKVDDVTGEKVREAFEQFLEDFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPFLQKGLRRVVRKYAPERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVRIQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDKPSSTLLTYKISFLACHVISIGSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKELRKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDVDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRLAFKVIKRLV 5u8t 6 4.90 BS02 ANP 2 1 V650 H653 P704 R708 V797 R798 V408 H411 P462 R466 V555 R556 3.6.4.12 28096349 LNHVKKVDDVTGEKVREAFEQFLEDFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPFLQKGLRRVVRKYAPERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVRIQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDKPSSTLLTYKISFLACHVISIGSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKELRKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDVDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRLAFKVIKRLV 5u8t 7 4.90 BS01 NUC F 1 F363 K364 F302 K303 3.6.4.12 28096349 ALPSIQLPVDYNNLFNEITDFLVTFKQDGPKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRAIDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPYTGFKALKAGLLTETYLEAQFVRQHKKSDVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQ 5u9h A 1.85 BS06 MN A 3 Y142 D145 H252 Y133 D136 H243 2.7.7.7,4.2.99.- 28108654 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 5uag D 3.40 BS03 ZN D 2 C814 C888 D889 C895 C898 C807 C881 D882 C888 C891 2.7.7.6 28009073 LKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERQQILTEEQYLDALEEFGDEFDAKMGAEAIQALLKSMDLEQECEQLREELNETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERLYRSGLASLHARVKVRITEYEKDANGELVAKTSLKDTTVGRAILWMIVPKGLPYSIVNQALGKKAISKMLNTCYRILGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIPEKKHEIISEAEAEVAEIQEQFQSGLVTAGERYNKVIDIWAAANDRVSKAMMDNLQTETVINRDGQEEKQVSFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTHEGIMMTPVIEGGDVKEPLRDRVLGRVTAEDVLKPGTADILVPRNTLLHEQWCDLLEENSVDAVKVRSVVSCDTDFGVCAHCYGRDLARGHIINKGEAIGVIAAQSIGEPGTQLTMTGGLPRVADLFEARRPKEPAILAEISGIVSFGKETKGKRRLVITPVDGSDPYEEMIPKWRQLNVFEGERVERGDVISDGPEAPHDILRLRGVHAVTRYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKATIVNAGSSDFLEGEQVEYSRVKIANRELEANGKVGATYSRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRRAAG 5ubr A 2.40 BS01 85S A 1 R770 M772 S774 P778 W780 I800 K802 Y836 E849 V850 V851 Q859 M922 I932 R621 M623 S625 P629 W631 I651 K653 Y687 E700 V701 V702 Q710 M765 I775 2.7.1.153 28108251 NREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRKSLWVINSALRIKILCATYVNVKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGG 5ubt A 2.83 BS01 85S A 1 M752 P758 W760 I777 K779 Y813 I825 E826 V828 T833 M900 I910 D911 M659 P665 W667 I681 K683 Y717 I729 E730 V732 T737 M789 I799 D800 2.7.1.153 28108251 NQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRTEEEQLQLREILEGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLLLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKT 5ucq B 1.40 BS03 POP B 1 K30 E32 R44 D71 D98 D103 Y140 K141 K30 E32 R44 D71 D98 D103 Y140 K141 3.6.1.1 MNPFHELEPGPEVPEVVYALIEIPKGSRNKYELDKKTGLLKLDRVLYSPFFYPVDYGIIPQTWYDDGDPFDIMVIMREPVYPLTIIEARPIGIMKMEDSGDKDWKVLAVPVEDPYFNDWKDISDVPKAFLDEIAHFFQRYKELQGKTTKIEGWGNAEEAKREILRAIEMYKEKFGK 5ucq C 1.40 BS04 POP C 1 K30 R44 Y56 D66 D68 D71 D98 D103 Y140 K141 K30 R44 Y56 D66 D68 D71 D98 D103 Y140 K141 3.6.1.1 MNPFHELEPGPEVPEVVYALIEIPKGSRNKYELDKKTGLLKLDRVLYSPFFYPVDYGIIPQTWYDDGDPFDIMVIMREPVYPLTIIEARPIGIMKMEDSGDKDWKVLAVPVEDPYFNDWKDISDVPKAFLDEIAHFFQRYKELQGKTTKIEGWGNAEEAKREILRAIEMYKEKFG 5uge A 1.80 BS01 584 A 1 I51 V69 P111 M131 D132 R133 F134 S181 L184 V196 I27 V45 P87 M107 D108 R109 F110 S157 L160 V172 2.7.11.1 AEQFAVGEIITDMAAAAWKVGLPIGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKAYAADPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPAANAPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDL 5uge B 1.80 BS01 584 B 1 I43 I51 V69 K71 M131 D132 R133 F134 S181 L184 I22 I25 V43 K45 M105 D106 R107 F108 S155 L158 2.7.11.1 QFAVGEIITDMAAAAWKVGLPIGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKAYAADPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPAANAPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDL 5uge C 1.80 BS01 584 C 1 I51 V69 K71 P111 M131 D132 R133 F134 L184 V196 D197 I18 V29 K31 P69 M84 D85 R86 F87 L137 V149 D150 2.7.11.1 TDMAAAAWKVGLPIGQCIYLADMNDAPCVVKVEPSGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKAYAADPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPAANAPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDL 5ugw A 2.31 BS01 GSH A 1 R972 K973 R1011 C1015 Q1018 R8 K9 R47 C51 Q54 2.7.7.49 KAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPA 5ugw A 2.31 BS02 GSH A 2 C982 H983 F986 N1000 K1003 C18 H19 F22 N36 K39 2.7.7.49 KAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPA 5uig A 3.50 BS01 EDT A 1 N39 T41 N42 R102 I292 E294 N36 T38 N39 R99 I368 E370 MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQ 5uig A 3.50 BS02 8D1 A 1 Y9 A63 I66 S67 V84 L85 F168 E169 M177 L249 H250 N253 L267 M270 Y271 I274 Y6 A60 I63 S64 V81 L82 F155 E156 M164 L325 H326 N329 L343 M346 Y347 I350 MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQ 5uj0 A 2.30 BS01 MG A 1 D165 D167 D278 D9 D11 D121 2.7.1.78,3.1.3.34 SKPKAVIFDVDGTLAKMGRGPYDLEKCDTDVINPMVVELSKMYALMGYQIVVVSGRESGTKEDPTKYYRMTRKWVEDIAGVPLVMQCQREQGDTRKDDVVKEEIFWKHIAPHFDVKLAIDDRTQVVEMWRRIGVECWQVASGD 5uj7 A 3.39 BS01 ATP A 1 E502 C506 P536 G539 K540 T541 A542 E621 Y681 I689 A719 L723 E13 C17 P47 G50 K51 T52 A53 E125 Y173 I181 A205 L209 28112645 EARLRLHVSAVPESLPCREQEFQDIYNFVESKLLDHTGGCMYISGVPGTGKTATVHEVIRCLQQAAQANDVPPFQYIEVNGMKLTEPHQVYVQILQKLTGQKATANHAAELLAKQFCTTVLLVDELDLLWTHKQDIMYNLFDWPTHKEARLVVLAIANTMDLPERTRMCFQPYTYSQLQQILRSRLKHLKIQLVARKVAALSGDARRCLDICRRATEICEFVTIAHSMEAVDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRNDLLLRVRLNVSQDDVLYALKDE 5uj7 A 3.39 BS02 MG A 1 T541 D620 E621 T52 D124 E125 28112645 EARLRLHVSAVPESLPCREQEFQDIYNFVESKLLDHTGGCMYISGVPGTGKTATVHEVIRCLQQAAQANDVPPFQYIEVNGMKLTEPHQVYVQILQKLTGQKATANHAAELLAKQFCTTVLLVDELDLLWTHKQDIMYNLFDWPTHKEARLVVLAIANTMDLPERTRMCFQPYTYSQLQQILRSRLKHLKIQLVARKVAALSGDARRCLDICRRATEICEFVTIAHSMEAVDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRNDLLLRVRLNVSQDDVLYALKDE 5uj7 C 3.39 BS01 ATP C 1 Q31 N36 F38 V40 P68 R69 G70 S71 G72 K73 T74 M75 L276 R277 H280 Q15 N20 F22 V24 P52 R53 G54 S55 G56 K57 T58 M59 L247 R248 H251 28112645 LSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEACPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMEYQLMKLLLDNTQIMNALQKYPNCPTDVRQWATSS 5uj7 C 3.39 BS02 MG C 1 T74 D159 T58 D134 28112645 LSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEACPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMEYQLMKLLLDNTQIMNALQKYPNCPTDVRQWATSS 5uj7 E 3.39 BS01 ATP E 1 L9 H38 T39 A40 G42 K43 T44 Y45 D125 Y182 I190 L222 R226 L2 H31 T32 A33 G35 K36 T37 Y38 D105 Y162 I170 L202 R206 28112645 VLCRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHVFVNCVECFTLRLLLEQILNKLNTCETFNDFVRLFKQVTTAENLKDQTVYIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIVWEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGERKLWRNIEPHLKKAMQTV 5uj7 B 3.39 BS01 ATP B 1 V500 E502 P536 G537 T538 G539 K540 T541 A542 E621 N654 I689 R720 L723 V11 E13 P47 G48 T49 G50 K51 T52 A53 E125 N158 I181 R206 L209 28112645 EARLRLHVSAVPESLPCREQEFQDIYNFVESKLLDHTGGCMYISGVPGTGKTATVHEVIRCLQQAAQANDVPPFQYIEVNGMKLTEPHQVYVQILQKLTGQKATANHAAELLAKQFCTTVLLVDELDLLWTHKQDIMYNLFDWPTHKEARLVVLAIANTMDLPERTRMCFQPYTYSQLQQILRSRLKHLKIQLVARKVAALSGDARRCLDICRRATEICEFVTIAHSMEAVDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRNDLLLRVRLNVSQDDVLYALKDE 5uj7 B 3.39 BS02 MG B 1 T541 D620 T52 D124 28112645 EARLRLHVSAVPESLPCREQEFQDIYNFVESKLLDHTGGCMYISGVPGTGKTATVHEVIRCLQQAAQANDVPPFQYIEVNGMKLTEPHQVYVQILQKLTGQKATANHAAELLAKQFCTTVLLVDELDLLWTHKQDIMYNLFDWPTHKEARLVVLAIANTMDLPERTRMCFQPYTYSQLQQILRSRLKHLKIQLVARKVAALSGDARRCLDICRRATEICEFVTIAHSMEAVDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRNDLLLRVRLNVSQDDVLYALKDE 5uj7 D 3.39 BS01 ATP D 1 Q31 F38 V40 P68 R69 G70 S71 G72 K73 T74 M75 L276 R277 Q15 F22 V24 P52 R53 G54 S55 G56 K57 T58 M59 L247 R248 28112645 LSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEACPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVFEKPVVMKAFEHLQQLELIKPMEYQLMKLLLDNTQIMNALQKYPNCPTDVRQWATSS 5uj7 F 3.39 BS01 ATP F 1 H38 T39 A40 G42 K43 T44 Y45 K126 E159 Y182 I190 L222 R226 H29 T30 A31 G33 K34 T35 Y36 K104 E137 Y160 I168 L200 R204 28112645 CRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHVFVNCVECFTLRLLLEQILNKLNTCETFNDFVRLFKQVTTAENLKDQTVYIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIVWEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGERKLWRNIEPHLKKAMQTV 5ujk A 1.53 BS01 NAD A 1 G12 Q13 I14 F33 D34 I35 V36 T78 A79 G80 V99 I119 T120 N121 M144 L148 H176 P235 G11 Q12 I13 F32 D33 I34 V35 T77 A78 G79 V98 I118 T119 N120 M143 L147 H175 P234 1.1.1.37 ARSKIALIGAGQIGGTLAHLAGLKELGDVVLFDIVDGVPQGKALDIAESAPVDGFDAKYSGASDYSAIAGADVVIVTAGVPRKPGMSRDDLIGINLKVMEAVGAGIKEHAPDAFVICITNPLDAMVWALQKFSGLPTNKVVGMAGVLDSARFRHFLAEEFGVSVEDVTAFVLGGHGDDMVPLTRYSTVAGVPLTDLVKLGWTTQEKLDAMVERTRKGGGEIVNLLKTGSAFYAPAASAIAMAESYLRDKKRVLPCAAYLDGQYGIDGLYVGVPVVIGENGVERVLEVTFNDDEKAMFEKSVNSVKGLIEACKSVN 5ujo A 1.35 BS01 8CY A 1 C69 S70 N104 Y105 S130 N132 P167 N170 T171 T235 G236 S237 G238 D240 C43 S44 N78 Y79 S104 N106 P141 N144 T145 T209 G210 S211 G212 D213 3.5.2.6 TSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTAPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 5ujo A 1.35 BS02 LSI A 1 I108 E121 A124 A125 Y129 I82 E95 A98 A99 Y103 3.5.2.6 TSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTAPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 5ujo B 1.35 BS02 LSI B 1 R43 R65 P174 G175 D176 R16 R37 P146 G147 D148 3.5.2.6 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTAPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 5wtk A 2.65 BS01 NUC B 1 N3 L4 F5 R29 Y58 K62 R73 K74 H76 N79 K85 I91 R219 D268 R310 E312 K313 V314 K315 K316 T329 Y330 K332 S333 Y334 L337 D338 K339 H340 K342 T398 F401 K405 Y408 D413 S414 K425 Y428 K429 Y432 R433 K436 K441 K471 R475 Q478 E482 K489 T502 F505 S506 H509 S672 S674 K675 L677 Q759 I760 A762 S763 K764 N767 I770 K771 Q774 N849 A850 N853 K854 N857 R858 W865 M882 N1115 Q1191 R1194 T1311 R1312 Y1313 N1315 S1316 E1323 K1326 K1327 K1337 K1357 V1358 V1360 N2 L3 F4 R28 Y57 K61 R72 K73 H75 N78 K84 I90 R146 D195 R237 E239 K240 V241 K242 K243 T256 Y257 K259 S260 Y261 L264 D265 K266 H267 K269 T325 F328 K332 Y335 D340 S341 K352 Y355 K356 Y359 R360 K363 K368 K398 R402 Q405 E409 K416 T429 F432 S433 H436 S596 S598 K599 L601 Q683 I684 A686 S687 K688 N691 I694 K695 Q698 N773 A774 N777 K778 N781 R782 W789 M806 N947 Q1023 R1026 T1143 R1144 Y1145 N1147 S1148 E1155 K1158 K1159 K1169 K1189 V1190 V1192 3.1.-.- 28086085 GNLFGHKRWYEVRDKKDFKIKRKVKVKRNYDGNKYILNINENNNKEKIDNNKFIRKYINYKKNDNILKEFTRKFHAGNILFKLKGKEGIIRIENNDDFLETLRIIENDELETKKSIYEIFKNINMSLYKIIEKIIENETEKVFENRYYEEHLREKLLKDDKIDVILTNFMEIREKIKSNLEILGFVKFYLNVGGDKKKSKNKKMLVEKILNINVDLTVEDIADFVIKELEFWNITKRIEKVKKVNNEFLEKRRNRTYIKSYVLLDKHEKFKIERENKKDKIVKFFVENIKNNSIKEKIEKILAEFKIDELIKKLEKELKKGNCDTEIFGIFKKHYKVNFDSKKFSKKSDEEKELYKIIYRYLKGRIEKILVNEQKVRLKKMEKIEIEKILNESILSEKILKRVKQYTLEHIMYLGKLRHNDIDMTTVNTDDFSRLHAKEELDLELITFFASTNMELNKIFSRENINNDENIDFFGGKNYVLDKKILNSKIKIIRDLDFIDNKNNITNNFIRKFTKIGTNERNRILHAISKERDLQGTQDDYNKVINIIQNLKISDEEVSKALNLDVVFKDKKNIITKINDIKISEENNNDIKYLPSFSKVLPEILNLYRNNPKNEPFDTIETEKIVLNALIYVNKELYKKLILEDDLEENESKNIFLQELKKTLGNIDEIDENIIENYYKNAQISASKGNNKAIKKYQKKVIECYIGYLRKNYEELFDFSDFKMNIQEIKKQIKDINDNKTYERITVKTSDKTIVINDDFEYIISIFALLNSNAVINKIRNRFFATSVWLNTSEYQNIIDILDEIMQLNTLRNECITENWNLNLEEFIQKMKEIEKDIKSKILCRIIFNSDFLKKYKKEIDNLIEDMESENENKFQEIYYPKERKNELYIYKKNLFLNIGNPNFDKIYGLISNDIKMADAKFLFNIDGKNIRKNKISEIDAILKNLNDKLNGYSKEYKEKYIKKLKENDDFFAKNIQNKNYKSFEKDYNRVSEYKKIRDLVEFNYLNKIESYLIDINWKLAIQMARFERDMHYIVNGLRELGIIKLSGYNTGISRAYPKRNGSDGFYTTTAYYKFFDEESYKKFEKICYGFGIDLSENSEINKPENESIRNYISHFYIVRNPFADYSIAEQIDRVSNLLSYSTRYNNSTYASVFEVFKKDVNLDYDELKKKFKLIGNNDILERLMKPKKVSVLELESYNSDYIKNLIIELLTKIE