2m98 A BS01 CA A 1 E15 D16 E17 K105 E15 D16 E17 K105 Q930Y6 24364624 GSHMTERRLRVLVVEDESMIAMLIEDTLCELGHEVAATASRMQEALDIARKGQFDIAIIDVNLDGEPSYPVADILAERNVPFIFATGYGSKGLDTRYSNIPLLTKPFLDSELEAVLVQISKEV 2m98 A BS02 BEF A 1 E15 D16 D60 V61 K105 E15 D16 D60 V61 K105 Q930Y6 24364624 GSHMTERRLRVLVVEDESMIAMLIEDTLCELGHEVAATASRMQEALDIARKGQFDIAIIDVNLDGEPSYPVADILAERNVPFIFATGYGSKGLDTRYSNIPLLTKPFLDSELEAVLVQISKEV 2miq A BS01 ZN A 1 C41 C44 H64 C67 C41 C44 H64 C67 1.14.11.- Q9VMJ7 SHMSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQ 2miq A BS02 ZN A 2 C56 G58 C59 C82 C85 C56 G58 C59 C82 C85 1.14.11.- Q9VMJ7 SHMSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQ 3w3h A 2.00 BS01 B29 A 1 G32 I36 L68 L71 F72 D75 Y136 L140 S165 I166 A167 V171 R204 N207 I275 Y280 R281 G32 I36 L68 L71 F72 D75 Y136 L140 S165 I166 A167 V171 R204 N207 I264 Y269 R270 Q45222 MIQTERAVQQVLEWGRSLTGFADEHAVEAVRGGQYILQRIHPSLRGTSARTGRDPQDETLIVTFYRELALLFWLDDCNDLGLISPEQLAAVEQALGQGVPCALPGFEGCAVLRASLATLAYDRRDYAQLLDDTRCYSAALRAGHAQAVAAERWSYAEYLHNGIDSIAYANVFCCLSLLWGLDMATLRARPAFRQVLRLISAIGRLQNDLHDNAVILLLQRYPAMPVVEFLNDELAGHTRMLHRVMAEERFPAPWGPLIEAMAAIRVQYYR 3w5f A 1.65 BS01 ARG A 1 K217 C229 N230 Y233 C234 E235 K198 C210 N211 Y214 C215 E216 3.2.1.23 O81100 EAEFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTALTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRS 3w5g A 3.00 BS01 NAG A 1 R238 N281 N282 Y348 A349 V351 R217 N260 N261 Y327 A328 V330 3.2.1.23 O81100 EFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRSA 3w5g A 3.00 BS02 NAG A 2 W455 E456 N459 W434 E435 N438 3.2.1.23 O81100 EFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRSA 3w5g A 3.00 BS03 GAL A 1 Y74 V117 C118 A119 E120 N180 E181 E250 W252 Y256 Y289 Y312 Y53 V96 C97 A98 E99 N159 E160 E229 W231 Y235 Y268 Y291 3.2.1.23 O81100 EFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRSA 3w5g A 3.00 BS04 GAL A 2 Y233 E235 F273 R277 T672 Y212 E214 F252 R256 T651 3.2.1.23 O81100 EFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRSA 3w5g A 3.00 BS05 GAL A 3 P519 K520 W555 P498 K499 W534 3.2.1.23 O81100 EFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRSA 3w5g A 3.00 BS06 GAL A 4 Q150 W199 Q129 W178 3.2.1.23 O81100 EFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRSA 3w5g B 3.00 BS01 GAL B 1 G716 S718 G695 S697 3.2.1.23 O81100 EFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRSA 3w5g B 3.00 BS02 NAG B 1 N281 N282 A349 V351 N260 N261 A328 V330 3.2.1.23 O81100 EFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRSA 3w5g B 3.00 BS03 NAG B 2 W455 E456 N459 W434 E435 N438 3.2.1.23 O81100 EFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRSA 3w5g B 3.00 BS04 GAL B 2 Y74 V117 C118 A119 E120 N180 E181 N230 E250 W252 Y256 Y289 Y312 Y53 V96 C97 A98 E99 N159 E160 N209 E229 W231 Y235 Y268 Y291 3.2.1.23 O81100 EFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRSA 3w5g B 3.00 BS05 GAL B 3 Y233 E235 R277 T672 Y212 E214 R256 T651 3.2.1.23 O81100 EFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRSA 3w5g B 3.00 BS06 GAL B 4 P519 K520 W555 N556 P498 K499 W534 N535 3.2.1.23 O81100 EFSVSYDDRAIIINGKRKILISGSIHYPRSTPQMWPDLIQKAKDGGLDVIETYVFWNGHEPSPGKYNFEGRYDLVRFIKMVQRAGLYVNLRIGPYVCAEWNFGGFPVWLKYVPGMEFRTNNQPFKVAMQGFVQKIVNMMKSENLFESQGGPIIMAQIENEYGPVEWEIGAPGKAYTKWAAQMAVGLKTGVPWIMCKQEDAPDPVIDTCNGFYCEGFRPNKPYKPKMWTEVWTGWYTKFGGPIPQRPAEDIAFSVARFVQNNGSFFNYYMYHGGTNFGRTSSGLFIATSYDYDAPLDEYGLLNEPKYGHLRDLHKAIKLSEPALVSSYAAVTSLGSNQEAHVYRSKSGACAAFLSNYDSRYSVKVTFQNRPYNLPPWSISILPDCKTAVYNTAQVNSQSSSIKMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDYLWYMTNVNIASNEGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLDNPKLTYSGNVKLRAGINKISLLSVSVGLPNVGVHYDTWNAGVLGPVTLSGLNEGSRNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSLMAQKQPLTWYKATFNAPGGNDPLALDMASMGKGQIWINGEGVGRHWPGYIAQGDCSKCSYAGTFNEKKCQTNCGQPSQRWYHVPRSWLKPSGNLLVVFEEWGGNPTGISLVRRSRSA 3w8m A 1.46 BS01 YOM A 1 H32 T43 F46 Y56 Y75 L77 H83 R129 H134 Y138 M141 H32 T43 F46 Y56 Y75 L77 H83 R129 H134 Y138 M141 G3XD33 MSISISYSTTYSGWTVADYLADWSAYFGDVNHRPGQVVDGSNTGGFNPGPFDGSQYALKSTASDAAFIAGGDLHYTLFSNPSHTLWGKLDSIALGDTLTGGASSGGYALDSQEVSFSNLGLDSPIAQGRDGTVHKVVYGLMSGDSSALQGQIDALLKAVDPSLSINSTFDQLAAAGVAHATPAA 3w8o A 1.85 BS01 WPC A 1 H32 P34 V37 T43 F46 Y56 Y75 F78 H83 L85 R129 H134 V137 Y138 M141 H32 P34 V37 T43 F46 Y56 Y75 F78 H83 L85 R129 H134 V137 Y138 M141 G3XD33 MSISISYSTTYSGWTVADYLADWSAYFGDVNHRPGQVVDGSNTGGFNPGPFDGSQYALKSTASDAAFIAGGDLHYTLFSNPSHTLWGKLDSIALGDTLTGGASSGGYALDSQEVSFSNLGLDSPIAQGRDGTVHKVVYGLMSGDSSALQGQIDALLKAVDPSLSINSTFDQLAAAGVAHATPAA 3w8o B 1.85 BS01 WPC B 1 H32 P34 V37 T43 F46 F51 Y56 Y75 L77 H83 L85 R129 H134 V137 Y138 M141 H32 P34 V37 T43 F46 F51 Y56 Y75 L77 H83 L85 R129 H134 V137 Y138 M141 G3XD33 MSISISYSTTYSGWTVADYLADWSAYFGDVNHRPGQVVDGSNTGGFNPGPFDGSQYALKSTASDAAFIAGGDLHYTLFSNPSHTLWGKLDSIALGDTLTGGASSGGYALDSQEVSFSNLGLDSPIAQGRDGTVHKVVYGLMSGDSSALQGQIDALLKAVDPSLSINSTFDQLAAAGVAHATPAA 3wah A 1.54 BS01 MH0 A 1 H32 P34 G35 V37 T43 F46 F51 Y56 Y75 L77 H83 L85 R129 H134 Y138 M141 H31 P33 G34 V36 T42 F45 F50 Y55 Y74 L76 H82 L84 R128 H133 Y137 M140 G3XD33 SISISYSTTYSGWTVADYLADWSAYFGDVNHRPGQVVDGSNTGGFNPGPFDGSQYALKSTASDAAFIAGGDLHYTLFSNPSHTLWGKLDSIALGDTLTGGASSGGYALDSQEVSFSNLGLDSPIAQGRDGTVHKVVYGLMSGDSSALQGQIDALLKAVDPSLSINSTFDQLAAAGVAHATPAA 3wah B 1.54 BS01 MH0 B 1 H32 P34 G35 V37 T43 F46 F51 Y56 Y75 L77 H83 L85 R129 H134 Y138 M141 H31 P33 G34 V36 T42 F45 F50 Y55 Y74 L76 H82 L84 R128 H133 Y137 M140 G3XD33 SISISYSTTYSGWTVADYLADWSAYFGDVNHRPGQVVDGSNTGGFNPGPFDGSQYALKSTASDAAFIAGGDLHYTLFSNPSHTLWGKLDSIALGDTLTGGASSGGYALDSQEVSFSNLGLDSPIAQGRDGTVHKVVYGLMSGDSSALQGQIDALLKAVDPSLSINSTFDQLAAAGVAHATPAA 3waz A 3.00 BS01 NUC C 1 T25 R26 P27 S45 T46 R47 K48 R184 N185 T18 R19 P20 S38 T39 R40 K41 R177 N178 Q9V2B6 EASVSFENGKIVVRLPITRPTSKIRVKKIENGVGIPVSTRKKSFPSDENLRDYYIEWQISYARDGKYDYELSRMVRLAHEHGILTYNDIYELLKFADDVKSYLEDKGIRRESTNEELYGFNIYEDVYPVAKKELPSGEFIGIVLKHAQRAVGYQSMVYVCIPLTNVEPSLAGRVARRNEVVKYEVPVDLMKELLKAFIIASETHKNDIVKFLRSII 3waz A 3.00 BS02 NUC D 1 T28 S29 K30 R32 E63 Q65 S67 Y68 A69 A154 Q155 R156 A157 V158 Q161 M163 Y165 D214 T21 S22 K23 R25 E56 Q58 S60 Y61 A62 A147 Q148 R149 A150 V151 Q154 M156 Y158 D207 Q9V2B6 EASVSFENGKIVVRLPITRPTSKIRVKKIENGVGIPVSTRKKSFPSDENLRDYYIEWQISYARDGKYDYELSRMVRLAHEHGILTYNDIYELLKFADDVKSYLEDKGIRRESTNEELYGFNIYEDVYPVAKKELPSGEFIGIVLKHAQRAVGYQSMVYVCIPLTNVEPSLAGRVARRNEVVKYEVPVDLMKELLKAFIIASETHKNDIVKFLRSII 3waz A 3.00 BS03 ADE A 1 Q65 I66 Y68 S162 M163 V164 F204 H211 Q58 I59 Y61 S155 M156 V157 F197 H204 Q9V2B6 EASVSFENGKIVVRLPITRPTSKIRVKKIENGVGIPVSTRKKSFPSDENLRDYYIEWQISYARDGKYDYELSRMVRLAHEHGILTYNDIYELLKFADDVKSYLEDKGIRRESTNEELYGFNIYEDVYPVAKKELPSGEFIGIVLKHAQRAVGYQSMVYVCIPLTNVEPSLAGRVARRNEVVKYEVPVDLMKELLKAFIIASETHKNDIVKFLRSII 3waz B 3.00 BS01 NUC C 1 T28 S29 K30 R32 E63 Q65 S67 Y68 A69 A154 Q155 R156 A157 V158 Q161 M163 Y165 T21 S22 K23 R25 E56 Q58 S60 Y61 A62 A147 Q148 R149 A150 V151 Q154 M156 Y158 Q9V2B6 EASVSFENGKIVVRLPITRPTSKIRVKKIENGVGIPVSTRKKSFPSDENLRDYYIEWQISYARDGKYDYELSRMVRLAHEHGILTYNDIYELLKFADDVKSYLEDKGIRRESTNEELYGFNIYEDVYPVAKKELPSGEFIGIVLKHAQRAVGYQSMVYVCIPLTNVEPSLAGRVARRNEVVKYEVPVDLMKELLKAFIIASETHKNDIVKFLRSIIG 3waz B 3.00 BS02 NUC D 1 T25 R26 P27 T28 S45 T46 R47 K48 R184 N185 T18 R19 P20 T21 S38 T39 R40 K41 R177 N178 Q9V2B6 EASVSFENGKIVVRLPITRPTSKIRVKKIENGVGIPVSTRKKSFPSDENLRDYYIEWQISYARDGKYDYELSRMVRLAHEHGILTYNDIYELLKFADDVKSYLEDKGIRRESTNEELYGFNIYEDVYPVAKKELPSGEFIGIVLKHAQRAVGYQSMVYVCIPLTNVEPSLAGRVARRNEVVKYEVPVDLMKELLKAFIIASETHKNDIVKFLRSIIG 3waz B 3.00 BS03 ADE B 1 Q65 I66 Y68 S162 M163 V164 F204 H211 Q58 I59 Y61 S155 M156 V157 F197 H204 Q9V2B6 EASVSFENGKIVVRLPITRPTSKIRVKKIENGVGIPVSTRKKSFPSDENLRDYYIEWQISYARDGKYDYELSRMVRLAHEHGILTYNDIYELLKFADDVKSYLEDKGIRRESTNEELYGFNIYEDVYPVAKKELPSGEFIGIVLKHAQRAVGYQSMVYVCIPLTNVEPSLAGRVARRNEVVKYEVPVDLMKELLKAFIIASETHKNDIVKFLRSIIG 3wha A 1.30 BS01 WHA A 1 D54 A55 K58 D93 I96 G97 M98 N106 L107 G135 F138 Y139 D39 A40 K43 D78 I81 G82 M83 N91 L92 G120 F123 Y124 P07900 24369839 EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEK 3wha B 1.30 BS01 WHA B 1 N51 D54 A55 D93 I96 G97 M98 N106 L107 G135 F138 Y139 N36 D39 A40 D78 I81 G82 M83 N91 L92 G120 F123 Y124 P07900 24369839 EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEK 3wkt A 4.30 BS01 FAD A 1 H315 R420 R450 Y451 Y452 S453 C468 A469 V472 Y474 G484 V485 A486 T487 W673 H250 R355 R385 Y386 Y387 S388 C403 A404 V407 Y409 G419 V420 A421 T422 W601 1.6.2.4 P00388 ESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEASSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 3wkt A 4.30 BS02 FMN A 1 S86 Q87 T88 G89 T90 A91 A138 T139 Y140 G141 L173 G174 N175 Y178 H180 F181 N182 L212 S21 Q22 T23 G24 T25 A26 A73 T74 Y75 G76 L108 G109 N110 Y113 H115 F116 N117 L147 1.6.2.4 P00388 ESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEASSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 3wkt A 4.30 BS03 NAP A 1 R294 P529 G530 T531 C562 R563 S592 R593 K598 Y600 Q602 N631 M632 R229 P457 G458 T459 C490 R491 S520 R521 K526 Y528 Q530 N559 M560 1.6.2.4 P00388 ESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEASSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 3wkt B 4.30 BS01 FAD B 1 H315 R420 R450 Y451 Y452 S453 C468 A469 V470 V472 Y474 K477 G484 V485 A486 T487 A534 W673 H235 R340 R370 Y371 Y372 S373 C388 A389 V390 V392 Y394 K397 G404 V405 A406 T407 A448 W587 1.6.2.4 P00388 VEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEASSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 3wkt B 4.30 BS02 FMN B 1 S86 Q87 T88 G89 T90 A91 A138 T139 Y140 G141 G143 L173 G174 N175 Y178 H180 F181 N182 D208 L212 S17 Q18 T19 G20 T21 A22 A58 T59 Y60 G61 G63 L93 G94 N95 Y98 H100 F101 N102 D128 L132 1.6.2.4 P00388 VEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEASSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 3wkt B 4.30 BS03 NAP B 1 R294 V470 G530 T531 C562 S592 R593 K598 Y600 V601 Q602 M632 R214 V390 G444 T445 C476 S506 R507 K512 Y514 V515 Q516 M546 1.6.2.4 P00388 VEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEASSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 3wkt C 4.30 BS01 HEM C 1 H25 Q38 Y134 T135 R136 L138 G139 S142 K179 R183 F207 N210 F214 H16 Q29 Y125 T126 R127 L129 G130 S133 K170 R174 F198 N201 F205 1.14.99.3 P06762 SQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTE 3wkt D 4.30 BS01 HEM D 1 K18 H25 A28 E29 M34 Q38 Y134 T135 R136 L138 G139 S142 G143 K179 R183 F207 N210 F214 K9 H16 A19 E20 M25 Q29 Y125 T126 R127 L129 G130 S133 G134 K170 R174 F198 N201 F205 1.14.99.3 P06762 SQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTE 3zev A 3.00 BS01 III C 1 S53 D54 L55 D56 N58 F128 H132 Y146 M208 L213 V224 T226 R327 F331 C332 I334 S335 D336 W339 F344 Y347 Y351 S3 D4 L5 D6 N8 F75 H79 Y93 M155 L160 V171 T173 R248 F252 C253 I255 S256 D257 W260 F265 Y268 Y272 P20789 PNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTLAC 3zev A 3.00 BS02 GLY A 1 K64 W130 K14 W77 P20789 PNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTLAC 3zev A 3.00 BS03 GLY A 2 R185 K188 R132 K135 P20789 PNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTLAC 3zev B 3.00 BS01 III D 1 D54 L55 D56 F128 H132 Y146 M208 L213 V224 T226 R327 F331 I334 S335 D336 E337 W339 F344 Y347 H348 D4 L5 D6 F72 H76 Y90 M152 L157 V168 T170 R245 F249 I252 S253 D254 E255 W257 F262 Y265 H266 P20789 PNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLASLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVTEPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTLAC 3zj3 A 3.37 BS01 III P 1 D225 L254 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 L221 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 B 3.37 BS01 III Q 1 D225 L254 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 L221 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 C 3.37 BS01 III R 1 D225 L254 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 L221 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 D 3.37 BS01 III S 1 D225 L254 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 L221 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 E 3.37 BS01 III T 1 D225 L254 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 L221 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 F 3.37 BS01 III U 1 D225 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 G 3.37 BS01 III V 1 D225 L254 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 D192 L221 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 H 3.37 BS01 III X 1 D225 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 D192 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 I 3.37 BS01 III Y 1 D225 L254 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 L221 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 J 3.37 BS01 III Z 1 D225 L254 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 L221 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 K 3.37 BS01 III 1 1 D225 L254 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 L221 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 L 3.37 BS01 III 2 1 D225 L254 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 L221 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 M 3.37 BS01 III 3 1 D225 L254 A255 S256 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 L221 A222 S223 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 N 3.37 BS01 III 4 1 D225 L254 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 L221 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj3 O 3.37 BS01 III 5 1 D225 L254 A255 S256 I258 V259 D284 A302 Y306 Y310 P311 Y312 S313 L315 D192 L221 A222 S223 I225 V226 D251 A269 Y273 Y277 P278 Y279 S280 L282 P01558 GAMGSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF 3zj6 A 2.40 BS01 VM2 A 1 Q36 H140 W141 N185 E186 T189 H193 Y347 W392 E420 W469 E476 W477 Q24 H128 W129 N173 E174 T177 H181 Y310 W348 E376 W425 E432 W433 3.2.1.125 Q9SPP9 DATRISRSDFPADFIMGTGSSAYQIEGGARDGGRGPSIWDTFTHRRPDMIRGGTNGDVAVDSYHLYKEDVNILKNLGLDAYRFSISWSRVLPGGRLSGGVNKEGINYYNNLIDGLLANGIKPFVTLFHWDVPQALEDEYGGFLSPRIVDDFCEYAELCFWEFGDRVKHWMTLNEPWTFSVHGYATGLYAPGRGRTGNPGTEPYWVTHHLLLAHAAAVELYKNKFQRGQEGQIGISHATQWMEPWDENSASDVEAAARALDFMLGWFMEPITSGDYPKSMKKFVGSRLPKFSPEQSKMLKGSYDFVGLNYYTASYVTNASNFSYNTDIHVTYETDRNGVPIGPQSGSDWLLIYPEGIRKILVYTKKTYNVPLIYVTENGVDDVKNTNLTLSEARKDSMRLKYLQDHIFNVRQAMNDGVNVKGYFAWSLLDNFEWGEGYGVRFGIIHIDYNDNFARYPKDSAVWLMNSFHK 3zj6 B 2.40 BS01 VM2 B 1 Q36 H140 W141 N185 E186 T189 H193 Y347 W392 E420 W469 E476 W477 Q24 H128 W129 N173 E174 T177 H181 Y310 W348 E376 W425 E432 W433 3.2.1.125 Q9SPP9 DATRISRSDFPADFIMGTGSSAYQIEGGARDGGRGPSIWDTFTHRRPDMIRGGTNGDVAVDSYHLYKEDVNILKNLGLDAYRFSISWSRVLPGGRLSGGVNKEGINYYNNLIDGLLANGIKPFVTLFHWDVPQALEDEYGGFLSPRIVDDFCEYAELCFWEFGDRVKHWMTLNEPWTFSVHGYATGLYAPGRGRTGNPGTEPYWVTHHLLLAHAAAVELYKNKFQRGQEGQIGISHATQWMEPWDENSASDVEAAARALDFMLGWFMEPITSGDYPKSMKKFVGSRLPKFSPEQSKMLKGSYDFVGLNYYTASYVTNASNFSYNTDIHVTYETDRNGVPIGPQSGSDWLLIYPEGIRKILVYTKKTYNVPLIYVTENGVDDVKNTNLTLSEARKDSMRLKYLQDHIFNVRQAMNDGVNVKGYFAWSLLDNFEWGEGYGVRFGIIHIDYNDNFARYPKDSAVWLMNSFHK 3zja A 1.48 BS01 CU A 1 H98 M105 H127 M129 H48 M55 H77 M79 Q93J41 AELSVDAAYIPQPVSDSMAAGFLTITNEGDSADELTSVTSEAGEVTVHETIDGTMKEVDRIEVPAHGQLVFKSGGNHLMFEKLKQQPKQGQSVAVELHFAHSDPVAVKLPVKAA 3zk4 A 1.65 BS01 FE A 1 D272 D313 Y316 H479 D251 D292 Y295 H458 3.1.3.2 Q8VX11 HAYIKATPNVLGFEGHYTEWVTLQYSNNKPSIDDWIGVFSPANFSASTCPGENKMTNPPFLCSAPIKFQYANFSSHSYKDTGKGSLKLQLINQRSDFSFALFTGGLTNPKLIAVSNKVSFVNPNAPVYPRLAQGKTWDEITVTWTSGYDINDAEPFVEWGPKEGNLVKTPAGTLTFDRNTMCGAPARTVGWRDPGYIHTSFLKELWPNREYTYKLGHRLFNGTTIWSKEYHFKASPYPGQSSVQRVVIFGDMGKAEADGSNEYNNFQPGSLNTTKQIIQDLEDIDIVFHIGDLCYANGYISQWDQFTAQIEPIASTVPYMTASGNHERDWPGTGSFYGNLDSGGECGVPAQTMFFVPAENREKFWYSTDYGMFRFCIAHTELDWRKGTEQYEFIEKCLASVDRQKQPWLIFLAHRVLGYSSAGFYVQEGSFEEPMGREDLQHLWQKYKVDIAMYGHVHNYERTCPIYQNVCTNKEKHNYKGNLNGTIHVVVGGGGASLAEFAPINTTWSIFKDHDFGFVKLTAFDHSNLLLEYRKSSDGQVYDSFTISRDYRDILACSVDSCPTTTLAS 3zk4 A 1.65 BS02 MN A 1 D272 D313 N346 H435 H477 D251 D292 N325 H414 H456 3.1.3.2 Q8VX11 HAYIKATPNVLGFEGHYTEWVTLQYSNNKPSIDDWIGVFSPANFSASTCPGENKMTNPPFLCSAPIKFQYANFSSHSYKDTGKGSLKLQLINQRSDFSFALFTGGLTNPKLIAVSNKVSFVNPNAPVYPRLAQGKTWDEITVTWTSGYDINDAEPFVEWGPKEGNLVKTPAGTLTFDRNTMCGAPARTVGWRDPGYIHTSFLKELWPNREYTYKLGHRLFNGTTIWSKEYHFKASPYPGQSSVQRVVIFGDMGKAEADGSNEYNNFQPGSLNTTKQIIQDLEDIDIVFHIGDLCYANGYISQWDQFTAQIEPIASTVPYMTASGNHERDWPGTGSFYGNLDSGGECGVPAQTMFFVPAENREKFWYSTDYGMFRFCIAHTELDWRKGTEQYEFIEKCLASVDRQKQPWLIFLAHRVLGYSSAGFYVQEGSFEEPMGREDLQHLWQKYKVDIAMYGHVHNYERTCPIYQNVCTNKEKHNYKGNLNGTIHVVVGGGGASLAEFAPINTTWSIFKDHDFGFVKLTAFDHSNLLLEYRKSSDGQVYDSFTISRDYRDILACSVDSCPTTTLAS 3zk4 B 1.65 BS01 FE B 1 D272 D313 Y316 H479 D253 D294 Y297 H460 3.1.3.2 Q8VX11 DEHAYIKATPNVLGFEGHYTEWVTLQYSNNKPSIDDWIGVFSPANFSASTCPGENKMTNPPFLCSAPIKFQYANFSSHSYKDTGKGSLKLQLINQRSDFSFALFTGGLTNPKLIAVSNKVSFVNPNAPVYPRLAQGKTWDEITVTWTSGYDINDAEPFVEWGPKEGNLVKTPAGTLTFDRNTMCGAPARTVGWRDPGYIHTSFLKELWPNREYTYKLGHRLFNGTTIWSKEYHFKASPYPGQSSVQRVVIFGDMGKAEADGSNEYNNFQPGSLNTTKQIIQDLEDIDIVFHIGDLCYANGYISQWDQFTAQIEPIASTVPYMTASGNHERDWPGTGSFYGNLDSGGECGVPAQTMFFVPAENREKFWYSTDYGMFRFCIAHTELDWRKGTEQYEFIEKCLASVDRQKQPWLIFLAHRVLGYSSAGFYVQEGSFEEPMGREDLQHLWQKYKVDIAMYGHVHNYERTCPIYQNVCTNKEKHNYKGNLNGTIHVVVGGGGASLAEFAPINTTWSIFKDHDFGFVKLTAFDHSNLLLEYRKSSDGQVYDSFTISRDYRDILACSVDSCPTTTLAS 3zk4 B 1.65 BS02 MN B 1 D272 D313 N346 H435 H477 D253 D294 N327 H416 H458 3.1.3.2 Q8VX11 DEHAYIKATPNVLGFEGHYTEWVTLQYSNNKPSIDDWIGVFSPANFSASTCPGENKMTNPPFLCSAPIKFQYANFSSHSYKDTGKGSLKLQLINQRSDFSFALFTGGLTNPKLIAVSNKVSFVNPNAPVYPRLAQGKTWDEITVTWTSGYDINDAEPFVEWGPKEGNLVKTPAGTLTFDRNTMCGAPARTVGWRDPGYIHTSFLKELWPNREYTYKLGHRLFNGTTIWSKEYHFKASPYPGQSSVQRVVIFGDMGKAEADGSNEYNNFQPGSLNTTKQIIQDLEDIDIVFHIGDLCYANGYISQWDQFTAQIEPIASTVPYMTASGNHERDWPGTGSFYGNLDSGGECGVPAQTMFFVPAENREKFWYSTDYGMFRFCIAHTELDWRKGTEQYEFIEKCLASVDRQKQPWLIFLAHRVLGYSSAGFYVQEGSFEEPMGREDLQHLWQKYKVDIAMYGHVHNYERTCPIYQNVCTNKEKHNYKGNLNGTIHVVVGGGGASLAEFAPINTTWSIFKDHDFGFVKLTAFDHSNLLLEYRKSSDGQVYDSFTISRDYRDILACSVDSCPTTTLAS 3zk4 C 1.65 BS01 FE C 1 D272 D313 Y316 H479 D250 D291 Y294 H457 3.1.3.2 Q8VX11 AYIKATPNVLGFEGHYTEWVTLQYSNNKPSIDDWIGVFSPANFSASTCPGENKMTNPPFLCSAPIKFQYANFSSHSYKDTGKGSLKLQLINQRSDFSFALFTGGLTNPKLIAVSNKVSFVNPNAPVYPRLAQGKTWDEITVTWTSGYDINDAEPFVEWGPKEGNLVKTPAGTLTFDRNTMCGAPARTVGWRDPGYIHTSFLKELWPNREYTYKLGHRLFNGTTIWSKEYHFKASPYPGQSSVQRVVIFGDMGKAEADGSNEYNNFQPGSLNTTKQIIQDLEDIDIVFHIGDLCYANGYISQWDQFTAQIEPIASTVPYMTASGNHERDWPGTGSFYGNLDSGGECGVPAQTMFFVPAENREKFWYSTDYGMFRFCIAHTELDWRKGTEQYEFIEKCLASVDRQKQPWLIFLAHRVLGYSSAGFYVQEGSFEEPMGREDLQHLWQKYKVDIAMYGHVHNYERTCPIYQNVCTNKEKHNYKGNLNGTIHVVVGGGGASLAEFAPINTTWSIFKDHDFGFVKLTAFDHSNLLLEYRKSSDGQVYDSFTISRDYRDILACSVDSCPTTTLAS 3zk4 C 1.65 BS02 MN C 1 D272 D313 N346 H435 H477 D250 D291 N324 H413 H455 3.1.3.2 Q8VX11 AYIKATPNVLGFEGHYTEWVTLQYSNNKPSIDDWIGVFSPANFSASTCPGENKMTNPPFLCSAPIKFQYANFSSHSYKDTGKGSLKLQLINQRSDFSFALFTGGLTNPKLIAVSNKVSFVNPNAPVYPRLAQGKTWDEITVTWTSGYDINDAEPFVEWGPKEGNLVKTPAGTLTFDRNTMCGAPARTVGWRDPGYIHTSFLKELWPNREYTYKLGHRLFNGTTIWSKEYHFKASPYPGQSSVQRVVIFGDMGKAEADGSNEYNNFQPGSLNTTKQIIQDLEDIDIVFHIGDLCYANGYISQWDQFTAQIEPIASTVPYMTASGNHERDWPGTGSFYGNLDSGGECGVPAQTMFFVPAENREKFWYSTDYGMFRFCIAHTELDWRKGTEQYEFIEKCLASVDRQKQPWLIFLAHRVLGYSSAGFYVQEGSFEEPMGREDLQHLWQKYKVDIAMYGHVHNYERTCPIYQNVCTNKEKHNYKGNLNGTIHVVVGGGGASLAEFAPINTTWSIFKDHDFGFVKLTAFDHSNLLLEYRKSSDGQVYDSFTISRDYRDILACSVDSCPTTTLAS 3zk5 A 1.89 BS01 HEM A 1 M92 L93 H100 R104 F111 I157 A243 G244 T247 T248 L251 P289 V290 A293 T294 R296 A346 F347 G348 I351 H352 C354 I355 G356 A360 M83 L84 H91 R95 F102 I148 A234 G235 T238 T239 L242 P280 V281 A284 T285 R287 A337 F338 G339 I342 H343 C345 I346 G347 A351 O87605 ASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 3zk5 A 1.89 BS02 Z18 A 1 W74 L81 E85 L88 E94 F178 V179 H238 I239 V242 A243 T294 M394 I395 W65 L72 E76 L79 E85 F169 V170 H229 I230 V233 A234 T285 M385 I386 O87605 ASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 3zk5 B 1.89 BS01 HEM B 1 K72 M92 L93 H100 R104 L240 A243 G244 T247 T248 L251 P289 V290 A293 T294 R296 A346 F347 G348 H352 C354 I355 G356 A360 K60 M80 L81 H88 R92 L228 A231 G232 T235 T236 L239 P277 V278 A281 T282 R284 A334 F335 G336 H340 C342 I343 G344 A348 O87605 PVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 3zk5 B 1.89 BS02 Z18 B 1 E85 L93 E94 F178 V179 H238 I239 V242 A243 T294 M394 I395 E73 L81 E82 F166 V167 H226 I227 V230 A231 T282 M382 I383 O87605 PVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4buo A 2.75 BS01 III C 1 D54 L55 D56 F128 H132 Y146 L213 V224 T226 R327 R328 F331 C332 I334 S335 D336 W339 F344 Y347 D3 L4 D5 F74 H78 Y92 L159 V170 T172 R247 R248 F251 C252 I254 S255 D256 W259 F264 Y267 P20789 NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTL 4buo A 2.75 BS02 GLY A 1 D103 Y104 D49 Y50 P20789 NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTL 4buo A 2.75 BS03 GLY A 2 E166 M181 F189 E112 M127 F135 P20789 NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTL 4buo A 2.75 BS04 GLY A 3 L247 L322 V326 L193 L242 V246 P20789 NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTL 4buo B 2.75 BS01 III D 1 L55 D56 F128 H132 Y146 M208 L213 V224 T226 R327 F331 C332 I334 D336 W339 F344 Y347 L7 D8 F74 H78 Y92 M154 L159 V170 T172 R255 F259 C260 I262 D264 W267 F272 Y275 P20789 SGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQAAFNMTIEPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTLAC 4buo B 2.75 BS02 GLY B 1 L115 W194 L61 W140 P20789 SGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQAAFNMTIEPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTLAC 4buo B 2.75 BS03 GLY B 2 Q99 R305 S373 N375 Q45 R233 S301 N303 P20789 SGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQAAFNMTIEPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTLAC 4buo B 2.75 BS04 GLY B 3 L180 M181 F189 L126 M127 F135 P20789 SGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQAAFNMTIEPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTLAC 4bv0 A 3.10 BS01 III C 1 D54 L55 D56 F128 H132 Y146 L213 V224 T226 R327 F331 V332 I334 D336 W339 F344 Y347 Y351 D3 L4 D5 F70 H74 Y88 L150 V161 T163 R237 F241 V242 I244 D246 W249 F254 Y257 Y261 P20789 NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNGVTLFTLARKSRVDYYLGSLALSDLLILLFALPVDVYNFIWVHHPWAFGDAGCKGYYFLREACTYATALNVVSLSVELYLAIRHPLMSRSRTKKFISAIWLASALLAIPMLFTVGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQLNTFMSFLFPMLVASILNTVIARRLTVMVHPGRVQALRRGVLVLRAMVIAFVVCWLPYHVRRLMFVYISDEQWTTALFDFYHYFYMLSNALVYVSAAINPILYNLVSANFRQVFLSTLACL 4bv0 B 3.10 BS01 III D 1 D54 L55 F128 H132 Y146 V224 T226 P227 R327 F331 I334 S335 D336 W339 F344 Y347 D4 L5 F72 H76 Y90 V167 T169 P170 R240 F244 I247 S248 D249 W252 F257 Y260 P20789 PNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNGVTLFTLARLQSRVDYYLGSLALSDLLILLFALPVDVYNFIWVHHPWAFGDAGCKGYYFLREACTYATALNVVSLSVELYLAIRHPFKHKTMSRSRTKKFISAIWLASALLAIPMLFTVGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQLNTFMSFLFPMLVASILNTVIARRLTVMVRVQALRRGVLVLRAMVIAFVVCWLPYHVRRLMFVYISDEQWTTALFDFYHYFYMLSNALVYVSAAINPILYNLVSANFRQVFLSTLACLCP 4bwb A 3.57 BS01 III C 1 D54 L55 D56 F128 V224 T226 F331 V332 I334 S335 D336 W339 F344 Y347 D3 L4 D5 F72 V168 T170 F248 V249 I251 S252 D253 W256 F261 Y264 P20789 NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNGVTLFTLAQSLQSRVDYYLGSLALSDLLILLFALPVDLYNFIWVHHPWAFGDAGCKGYYFLREACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLRVVIQLNTFMSFLFPMLVASILNTVAARRLTVMVEPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFVYISDEQWTTALFDFYHYFYMLSNALVYVSAAINPILYNLVSANFRQVFLSTLACLC 4bwb B 3.57 BS01 III D 1 L55 F128 H133 V224 T226 F331 W339 F344 Y347 Y351 L3 F70 H75 V164 T166 F247 W255 F260 Y263 Y267 P20789 SDLDVNTDIYSKVLVTAIYLALFVVGTVGNGVTLFTLARKKSRVDYYLGSLALSDLLILLFALPVDLYNFIWVHHPWAFGDAGCKGYYFLREACTYATALNVVSLSVELYLAICHPAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGGLVCTPIVDTATLRVVIQLNTFMSFLFPMLVASILNTVAARRLTVMVHQAAPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFVYISDEQWTTALFDFYHYFYMLSNALVYVSAAINPILYNLVSANFRQVFLSTL 4c3o A 3.20 BS01 NFU A 1 C76 C79 T82 H83 A510 P511 R512 L515 V533 P534 T535 C579 C582 C74 C77 T80 H81 A508 P509 R510 L513 V531 P532 T533 C577 C580 1.12.7.2 Q8ZPH0 24428762 YPYQTQGFTLDNSGRRIVVDPVTRIEGHMRCEVNIDSNNVITNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTGTHALTSIRAVENALGIAIPDNANCIRNMMQATLHVHDHLVHFYHLHALDWVDVVAALKADPHQTSAIAQSLSAWPLSSPGYFRDLQNRLKRFIESGQLGPFRNGYWGHPAMKLPPEANLLAVAHYLEALDFQKEIVKIHTVFGGKNPHPNWLVGGVPCAINLDETGAVGAVNMERLNLVSSIIQKARQFCEQVYLPDVLLIASYYKDWAKIGGGLSSMNLLAYGEFPDNPNDYSASNLLLPRGAIINGRFDEIHPVDLTAPDEIQEFVTHSWYTYGNGNNDKGLHPWDGLTEPQLVMGEHYKGTKTFIEQVDESAKYSWIKSPRWKGHAMEVGPLARYLIGYHQNKPEFKEPVDQLLSVLKLPKEALFSTLGRTAARALESVWAGNTLQYFFDRLMRNLKSGDTATANVTLWEPDTWPTSAKGVGFSEAPRGALGHWIKIANQKIDSYQCVVPTTWNAGPRDDKGQIGAYEAALMGTKLAVPDQPLEILRTLHSFDPCLACSTH 4c3o A 3.20 BS02 F4S B 1 R74 H229 R72 H227 1.12.7.2 Q8ZPH0 24428762 YPYQTQGFTLDNSGRRIVVDPVTRIEGHMRCEVNIDSNNVITNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTGTHALTSIRAVENALGIAIPDNANCIRNMMQATLHVHDHLVHFYHLHALDWVDVVAALKADPHQTSAIAQSLSAWPLSSPGYFRDLQNRLKRFIESGQLGPFRNGYWGHPAMKLPPEANLLAVAHYLEALDFQKEIVKIHTVFGGKNPHPNWLVGGVPCAINLDETGAVGAVNMERLNLVSSIIQKARQFCEQVYLPDVLLIASYYKDWAKIGGGLSSMNLLAYGEFPDNPNDYSASNLLLPRGAIINGRFDEIHPVDLTAPDEIQEFVTHSWYTYGNGNNDKGLHPWDGLTEPQLVMGEHYKGTKTFIEQVDESAKYSWIKSPRWKGHAMEVGPLARYLIGYHQNKPEFKEPVDQLLSVLKLPKEALFSTLGRTAARALESVWAGNTLQYFFDRLMRNLKSGDTATANVTLWEPDTWPTSAKGVGFSEAPRGALGHWIKIANQKIDSYQCVVPTTWNAGPRDDKGQIGAYEAALMGTKLAVPDQPLEILRTLHSFDPCLACSTH 4c3o A 3.20 BS03 MG A 1 E57 E347 K402 Q530 C531 H585 E55 E345 K400 Q528 C529 H583 1.12.7.2 Q8ZPH0 24428762 YPYQTQGFTLDNSGRRIVVDPVTRIEGHMRCEVNIDSNNVITNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTGTHALTSIRAVENALGIAIPDNANCIRNMMQATLHVHDHLVHFYHLHALDWVDVVAALKADPHQTSAIAQSLSAWPLSSPGYFRDLQNRLKRFIESGQLGPFRNGYWGHPAMKLPPEANLLAVAHYLEALDFQKEIVKIHTVFGGKNPHPNWLVGGVPCAINLDETGAVGAVNMERLNLVSSIIQKARQFCEQVYLPDVLLIASYYKDWAKIGGGLSSMNLLAYGEFPDNPNDYSASNLLLPRGAIINGRFDEIHPVDLTAPDEIQEFVTHSWYTYGNGNNDKGLHPWDGLTEPQLVMGEHYKGTKTFIEQVDESAKYSWIKSPRWKGHAMEVGPLARYLIGYHQNKPEFKEPVDQLLSVLKLPKEALFSTLGRTAARALESVWAGNTLQYFFDRLMRNLKSGDTATANVTLWEPDTWPTSAKGVGFSEAPRGALGHWIKIANQKIDSYQCVVPTTWNAGPRDDKGQIGAYEAALMGTKLAVPDQPLEILRTLHSFDPCLACSTH 4c3o B 3.20 BS01 SF4 B 1 H187 C190 R192 R193 F196 C215 L216 Y217 C221 P224 I243 H184 C187 R189 R190 F193 C212 L213 Y214 C218 P221 I240 1.12.7.2 Q8ZPG9 24428762 KPRTPVIWLHGLECTCCTESFIRSAHPLAKDAILSLISLDYDDTIMAAAGQQAEQALADVMREYKGNYIVAVEGNAPLNEDGMFCILAGEPFLEKLKRVSADAKAIIAWGSCASWGCVQAARPNPTKATPVHKLITDKPIIKVPGCPPIPEVMSAVITYMLAFDRIPPLDRLGRPKMFYGQRIHDKCYRRAHFDAGQFVEAWDDEGARKGYCLYKMGCKGPTTYNACSTVRWNDGVSFPIQSGHGCLGCSEDGFWDYGSFYSR 4c3o B 3.20 BS02 F3S B 1 I186 T226 N228 C230 W235 P242 C249 L250 G251 C252 I183 T223 N225 C227 W232 P239 C246 L247 G248 C249 1.12.7.2 Q8ZPG9 24428762 KPRTPVIWLHGLECTCCTESFIRSAHPLAKDAILSLISLDYDDTIMAAAGQQAEQALADVMREYKGNYIVAVEGNAPLNEDGMFCILAGEPFLEKLKRVSADAKAIIAWGSCASWGCVQAARPNPTKATPVHKLITDKPIIKVPGCPPIPEVMSAVITYMLAFDRIPPLDRLGRPKMFYGQRIHDKCYRRAHFDAGQFVEAWDDEGARKGYCLYKMGCKGPTTYNACSTVRWNDGVSFPIQSGHGCLGCSEDGFWDYGSFYSR 4c3o B 3.20 BS03 F4S B 1 E16 C17 T18 C19 C20 E76 S114 C115 C120 C149 E13 C14 T15 C16 C17 E73 S111 C112 C117 C146 1.12.7.2 Q8ZPG9 24428762 KPRTPVIWLHGLECTCCTESFIRSAHPLAKDAILSLISLDYDDTIMAAAGQQAEQALADVMREYKGNYIVAVEGNAPLNEDGMFCILAGEPFLEKLKRVSADAKAIIAWGSCASWGCVQAARPNPTKATPVHKLITDKPIIKVPGCPPIPEVMSAVITYMLAFDRIPPLDRLGRPKMFYGQRIHDKCYRRAHFDAGQFVEAWDDEGARKGYCLYKMGCKGPTTYNACSTVRWNDGVSFPIQSGHGCLGCSEDGFWDYGSFYSR 4c3o C 3.20 BS01 NFU C 1 C76 C79 T82 H83 A510 P511 R512 L515 V533 P534 T535 C579 C582 C74 C77 T80 H81 A508 P509 R510 L513 V531 P532 T533 C577 C580 1.12.7.2 Q8ZPH0 24428762 YPYQTQGFTLDNSGRRIVVDPVTRIEGHMRCEVNIDSNNVITNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTGTHALTSIRAVENALGIAIPDNANCIRNMMQATLHVHDHLVHFYHLHALDWVDVVAALKADPHQTSAIAQSLSAWPLSSPGYFRDLQNRLKRFIESGQLGPFRNGYWGHPAMKLPPEANLLAVAHYLEALDFQKEIVKIHTVFGGKNPHPNWLVGGVPCAINLDETGAVGAVNMERLNLVSSIIQKARQFCEQVYLPDVLLIASYYKDWAKIGGGLSSMNLLAYGEFPDNPNDYSASNLLLPRGAIINGRFDEIHPVDLTAPDEIQEFVTHSWYTYGNGNNDKGLHPWDGLTEPQLVMGEHYKGTKTFIEQVDESAKYSWIKSPRWKGHAMEVGPLARYLIGYHQNKPEFKEPVDQLLSVLKLPKEALFSTLGRTAARALESVWAGNTLQYFFDRLMRNLKSGDTATANVTLWEPDTWPTSAKGVGFSEAPRGALGHWIKIANQKIDSYQCVVPTTWNAGPRDDKGQIGAYEAALMGTKLAVPDQPLEILRTLHSFDPCLACSTH 4c3o C 3.20 BS02 MG C 1 E57 E347 K402 Q530 C531 H585 E55 E345 K400 Q528 C529 H583 1.12.7.2 Q8ZPH0 24428762 YPYQTQGFTLDNSGRRIVVDPVTRIEGHMRCEVNIDSNNVITNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTGTHALTSIRAVENALGIAIPDNANCIRNMMQATLHVHDHLVHFYHLHALDWVDVVAALKADPHQTSAIAQSLSAWPLSSPGYFRDLQNRLKRFIESGQLGPFRNGYWGHPAMKLPPEANLLAVAHYLEALDFQKEIVKIHTVFGGKNPHPNWLVGGVPCAINLDETGAVGAVNMERLNLVSSIIQKARQFCEQVYLPDVLLIASYYKDWAKIGGGLSSMNLLAYGEFPDNPNDYSASNLLLPRGAIINGRFDEIHPVDLTAPDEIQEFVTHSWYTYGNGNNDKGLHPWDGLTEPQLVMGEHYKGTKTFIEQVDESAKYSWIKSPRWKGHAMEVGPLARYLIGYHQNKPEFKEPVDQLLSVLKLPKEALFSTLGRTAARALESVWAGNTLQYFFDRLMRNLKSGDTATANVTLWEPDTWPTSAKGVGFSEAPRGALGHWIKIANQKIDSYQCVVPTTWNAGPRDDKGQIGAYEAALMGTKLAVPDQPLEILRTLHSFDPCLACSTH 4c3o C 3.20 BS03 F4S D 1 R74 H229 R72 H227 1.12.7.2 Q8ZPH0 24428762 YPYQTQGFTLDNSGRRIVVDPVTRIEGHMRCEVNIDSNNVITNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTGTHALTSIRAVENALGIAIPDNANCIRNMMQATLHVHDHLVHFYHLHALDWVDVVAALKADPHQTSAIAQSLSAWPLSSPGYFRDLQNRLKRFIESGQLGPFRNGYWGHPAMKLPPEANLLAVAHYLEALDFQKEIVKIHTVFGGKNPHPNWLVGGVPCAINLDETGAVGAVNMERLNLVSSIIQKARQFCEQVYLPDVLLIASYYKDWAKIGGGLSSMNLLAYGEFPDNPNDYSASNLLLPRGAIINGRFDEIHPVDLTAPDEIQEFVTHSWYTYGNGNNDKGLHPWDGLTEPQLVMGEHYKGTKTFIEQVDESAKYSWIKSPRWKGHAMEVGPLARYLIGYHQNKPEFKEPVDQLLSVLKLPKEALFSTLGRTAARALESVWAGNTLQYFFDRLMRNLKSGDTATANVTLWEPDTWPTSAKGVGFSEAPRGALGHWIKIANQKIDSYQCVVPTTWNAGPRDDKGQIGAYEAALMGTKLAVPDQPLEILRTLHSFDPCLACSTH 4c3o D 3.20 BS01 SF4 D 1 H187 C190 R192 R193 F196 C215 L216 Y217 C221 G223 P224 I243 H183 C186 R188 R189 F192 C211 L212 Y213 C217 G219 P220 I239 1.12.7.2 Q8ZPG9 24428762 PRTPVIWLHGLECTCCTESFIRSAHPLAKDAILSLISLDYDDTIMAAAGQQAEQALADVMREYKGNYIVAVEGNAPLNEDGMFCILAGEPFLEKLKRVSADAKAIIAWGSCASWGCVQAARPNPTKATPVHKLITDKPIIKVPGCPPIPEVMSAVITYMLAFDRIPPLDRLGRPKMFYGQRIHDKCYRRAHFDAGQFVEAWDDEGARKGYCLYKMGCKGPTTYNACSTVRWNDGVSFPIQSGHGCLGCSEDGFWDYGSFYSR 4c3o D 3.20 BS02 F3S D 1 I186 T226 N228 C230 W235 P242 C249 L250 G251 C252 I182 T222 N224 C226 W231 P238 C245 L246 G247 C248 1.12.7.2 Q8ZPG9 24428762 PRTPVIWLHGLECTCCTESFIRSAHPLAKDAILSLISLDYDDTIMAAAGQQAEQALADVMREYKGNYIVAVEGNAPLNEDGMFCILAGEPFLEKLKRVSADAKAIIAWGSCASWGCVQAARPNPTKATPVHKLITDKPIIKVPGCPPIPEVMSAVITYMLAFDRIPPLDRLGRPKMFYGQRIHDKCYRRAHFDAGQFVEAWDDEGARKGYCLYKMGCKGPTTYNACSTVRWNDGVSFPIQSGHGCLGCSEDGFWDYGSFYSR 4c3o D 3.20 BS03 F4S D 1 E16 C17 T18 C19 C20 E76 C115 C120 C149 E12 C13 T14 C15 C16 E72 C111 C116 C145 1.12.7.2 Q8ZPG9 24428762 PRTPVIWLHGLECTCCTESFIRSAHPLAKDAILSLISLDYDDTIMAAAGQQAEQALADVMREYKGNYIVAVEGNAPLNEDGMFCILAGEPFLEKLKRVSADAKAIIAWGSCASWGCVQAARPNPTKATPVHKLITDKPIIKVPGCPPIPEVMSAVITYMLAFDRIPPLDRLGRPKMFYGQRIHDKCYRRAHFDAGQFVEAWDDEGARKGYCLYKMGCKGPTTYNACSTVRWNDGVSFPIQSGHGCLGCSEDGFWDYGSFYSR 4c3o E 3.20 BS01 F4S F 1 R74 H229 R72 H227 1.12.7.2 Q8ZPH0 24428762 YPYQTQGFTLDNSGRRIVVDPVTRIEGHMRCEVNIDSNNVITNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTGTHALTSIRAVENALGIAIPDNANCIRNMMQATLHVHDHLVHFYHLHALDWVDVVAALKADPHQTSAIAQSLSAWPLSSPGYFRDLQNRLKRFIESGQLGPFRNGYWGHPAMKLPPEANLLAVAHYLEALDFQKEIVKIHTVFGGKNPHPNWLVGGVPCAINLDETGAVGAVNMERLNLVSSIIQKARQFCEQVYLPDVLLIASYYKDWAKIGGGLSSMNLLAYGEFPDNPNDYSASNLLLPRGAIINGRFDEIHPVDLTAPDEIQEFVTHSWYTYGNGNNDKGLHPWDGLTEPQLVMGEHYKGTKTFIEQVDESAKYSWIKSPRWKGHAMEVGPLARYLIGYHQNKPEFKEPVDQLLSVLKLPKEALFSTLGRTAARALESVWAGNTLQYFFDRLMRNLKSGDTATANVTLWEPDTWPTSAKGVGFSEAPRGALGHWIKIANQKIDSYQCVVPTTWNAGPRDDKGQIGAYEAALMGTKLAVPDQPLEILRTLHSFDPCLACSTH 4c3o E 3.20 BS02 NFU E 1 C76 C79 T82 H83 A510 P511 R512 L515 V533 P534 T535 C579 C582 C74 C77 T80 H81 A508 P509 R510 L513 V531 P532 T533 C577 C580 1.12.7.2 Q8ZPH0 24428762 YPYQTQGFTLDNSGRRIVVDPVTRIEGHMRCEVNIDSNNVITNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTGTHALTSIRAVENALGIAIPDNANCIRNMMQATLHVHDHLVHFYHLHALDWVDVVAALKADPHQTSAIAQSLSAWPLSSPGYFRDLQNRLKRFIESGQLGPFRNGYWGHPAMKLPPEANLLAVAHYLEALDFQKEIVKIHTVFGGKNPHPNWLVGGVPCAINLDETGAVGAVNMERLNLVSSIIQKARQFCEQVYLPDVLLIASYYKDWAKIGGGLSSMNLLAYGEFPDNPNDYSASNLLLPRGAIINGRFDEIHPVDLTAPDEIQEFVTHSWYTYGNGNNDKGLHPWDGLTEPQLVMGEHYKGTKTFIEQVDESAKYSWIKSPRWKGHAMEVGPLARYLIGYHQNKPEFKEPVDQLLSVLKLPKEALFSTLGRTAARALESVWAGNTLQYFFDRLMRNLKSGDTATANVTLWEPDTWPTSAKGVGFSEAPRGALGHWIKIANQKIDSYQCVVPTTWNAGPRDDKGQIGAYEAALMGTKLAVPDQPLEILRTLHSFDPCLACSTH 4c3o E 3.20 BS03 MG E 1 E57 E347 C531 H585 E55 E345 C529 H583 1.12.7.2 Q8ZPH0 24428762 YPYQTQGFTLDNSGRRIVVDPVTRIEGHMRCEVNIDSNNVITNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTGTHALTSIRAVENALGIAIPDNANCIRNMMQATLHVHDHLVHFYHLHALDWVDVVAALKADPHQTSAIAQSLSAWPLSSPGYFRDLQNRLKRFIESGQLGPFRNGYWGHPAMKLPPEANLLAVAHYLEALDFQKEIVKIHTVFGGKNPHPNWLVGGVPCAINLDETGAVGAVNMERLNLVSSIIQKARQFCEQVYLPDVLLIASYYKDWAKIGGGLSSMNLLAYGEFPDNPNDYSASNLLLPRGAIINGRFDEIHPVDLTAPDEIQEFVTHSWYTYGNGNNDKGLHPWDGLTEPQLVMGEHYKGTKTFIEQVDESAKYSWIKSPRWKGHAMEVGPLARYLIGYHQNKPEFKEPVDQLLSVLKLPKEALFSTLGRTAARALESVWAGNTLQYFFDRLMRNLKSGDTATANVTLWEPDTWPTSAKGVGFSEAPRGALGHWIKIANQKIDSYQCVVPTTWNAGPRDDKGQIGAYEAALMGTKLAVPDQPLEILRTLHSFDPCLACSTH 4c3o F 3.20 BS01 F4S F 1 E16 C17 T18 C19 C20 E76 S114 C115 C120 C149 E12 C13 T14 C15 C16 E72 S110 C111 C116 C145 1.12.7.2 Q8ZPG9 24428762 PRTPVIWLHGLECTCCTESFIRSAHPLAKDAILSLISLDYDDTIMAAAGQQAEQALADVMREYKGNYIVAVEGNAPLNEDGMFCILAGEPFLEKLKRVSADAKAIIAWGSCASWGCVQAARPNPTKATPVHKLITDKPIIKVPGCPPIPEVMSAVITYMLAFDRIPPLDRLGRPKMFYGQRIHDKCYRRAHFDAGQFVEAWDDEGARKGYCLYKMGCKGPTTYNACSTVRWNDGVSFPIQSGHGCLGCSEDGFWDYGSFYSRA 4c3o F 3.20 BS02 SF4 F 1 H187 C190 R192 R193 F196 C215 L216 Y217 C221 G223 I243 H183 C186 R188 R189 F192 C211 L212 Y213 C217 G219 I239 1.12.7.2 Q8ZPG9 24428762 PRTPVIWLHGLECTCCTESFIRSAHPLAKDAILSLISLDYDDTIMAAAGQQAEQALADVMREYKGNYIVAVEGNAPLNEDGMFCILAGEPFLEKLKRVSADAKAIIAWGSCASWGCVQAARPNPTKATPVHKLITDKPIIKVPGCPPIPEVMSAVITYMLAFDRIPPLDRLGRPKMFYGQRIHDKCYRRAHFDAGQFVEAWDDEGARKGYCLYKMGCKGPTTYNACSTVRWNDGVSFPIQSGHGCLGCSEDGFWDYGSFYSRA 4c3o F 3.20 BS03 F3S F 1 I186 T226 N228 C230 W235 P242 C249 L250 G251 C252 I182 T222 N224 C226 W231 P238 C245 L246 G247 C248 1.12.7.2 Q8ZPG9 24428762 PRTPVIWLHGLECTCCTESFIRSAHPLAKDAILSLISLDYDDTIMAAAGQQAEQALADVMREYKGNYIVAVEGNAPLNEDGMFCILAGEPFLEKLKRVSADAKAIIAWGSCASWGCVQAARPNPTKATPVHKLITDKPIIKVPGCPPIPEVMSAVITYMLAFDRIPPLDRLGRPKMFYGQRIHDKCYRRAHFDAGQFVEAWDDEGARKGYCLYKMGCKGPTTYNACSTVRWNDGVSFPIQSGHGCLGCSEDGFWDYGSFYSRA 4ccb A 2.03 BS01 OFG A 1 L1122 G1123 V1130 A1148 L1196 E1197 M1199 G1202 R1253 N1254 L1256 G1269 D1270 L30 G31 V38 A48 L96 E97 M99 G102 R150 N151 L153 G166 D167 2.7.10.1 Q9UM73 24432909 NPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIE 4ccu A 2.00 BS01 AWF A 1 L1122 G1123 V1130 A1148 L1196 E1197 M1199 G1202 D1203 R1253 N1254 L1256 G1269 D1270 L30 G31 V35 A45 L93 E94 M96 G99 D100 R150 N151 L153 G166 D167 2.7.10.1 Q9UM73 24432909 NPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGEVYEGQVPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEY 4cd0 A 2.23 BS01 AWJ A 1 L1122 V1130 A1148 M1196 E1197 M1199 G1202 D1203 S1206 R1253 N1254 L1256 G1269 D1270 L29 V37 A48 M96 E97 M99 G102 D103 S106 R153 N154 L156 G169 D170 2.7.10.1 Q9UM73 24432909 PNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILMELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEY 4ce1 A 2.01 BS01 7FK A 1 N37 A41 D79 I82 M84 N92 L93 F124 T171 L173 N37 A41 D79 I82 M84 N92 L93 F124 T171 L173 P02829 MASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEPDLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDDQLEYLEEKRIKEVIKRHSEFVAYPIQLVVTKEVE 4ce2 A 2.38 BS01 BO5 A 1 N37 A41 D79 I82 M84 N92 L93 F124 T171 L173 N37 A41 D79 I82 M84 N92 L93 F124 T171 L173 P02829 24435512 MASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEPDLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDDQLEYLEEKRIKEVIKRHSEFVAYPIQLVVTKEVE 4ce3 A 2.31 BS01 L4V A 1 N37 A41 D79 I82 M84 N92 F124 T171 L173 N37 A41 D79 I82 M84 N92 F124 T171 L173 P02829 24435512 MASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEPDLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDDQLEYLEEKRIKEVIKRHSEFVAYPIQLVVTKEVE 4fdu A 2.29 BS01 IHS A 1 T30 R58 H59 R62 T65 R149 R183 R275 Q276 K280 H323 A324 E325 T12 R31 H32 R35 T38 R122 R156 R248 Q249 K253 H296 A297 E298 Q89YI8 HMQTKIQKYAGTAMPYPNRTMTPFYINHLGRHGARFPTSRKALDKVEKVLVSAQQENGLTSEGMALLSMIRRLSRLFDGQWGKLSKLGETEQEGIAGRMIRNYPQLFSNSAKIEAIATYVPRSINSMDAFLSCMIRHNPALQVQRSEGKQYNHILRFFDLNKSYVNYKEKGDWLPIYKAFVHKKISPVPIMKKFLLNPEQYLDKEAEEFVMALFSVAAILPDTSIPLNLEDLFTLDEWHRYWQTQNLRQYMSKSSAPVGKMLPVAIAWPLLSEFIRSAQEVISGKSDYQANFRFAHAETVIPFVSLMGIEKTDVQVCRPDSVSVYWKDYEISPMAANVQWLFYRDRDQRIWVKILLNEEAAALPISTACFPYYSWEKTRIFFNQRIEMAKKTLSVFN 4fdu B 2.29 BS01 IHS B 1 T30 R58 H59 R62 T65 R149 R183 F185 Q276 K280 H323 A324 E325 T10 R29 H30 R33 T36 R120 R154 F156 Q247 K251 H294 A295 E296 Q89YI8 QTKIQKYAGTAMPYPNRTMTPFYINHLGRHGARFPTSRKALDKVEKVLVSAQQENGLTSEGMALLSMIRRLSRLFDGQWGKLSKLGETEQEGIAGRMIRNYPQLFSNSAKIEAIATYVPRSINSMDAFLSCMIRHNPALQVQRSEGKQYNHILRFFDLNKSYVNYKEKGDWLPIYKAFVHKKISPVPIMKKFLLNPEQYLDKEAEEFVMALFSVAAILPDTSIPLNLEDLFTLDEWHRYWQTQNLRQYMSKSSAPVGKMLPVAIAWPLLSEFIRSAQEVISGKSDYQANFRFAHAETVIPFVSLMGIEKTDVQVCRPDSVSVYWKDYEISPMAANVQWLFYRDRDQRIWVKILLNEEAAALPISTACFPYYSWEKTRIFFNQRIEMAKKTLSVFN 4g95 A 1.35 BS01 OAG A 1 I7 V8 A9 L22 E30 F31 F34 S59 P61 I7 V8 A9 L22 E30 F31 F34 S59 P61 1.5.1.3 P00374 23545530 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 4hnp H 2.80 BS01 ONK H 1 T1 S20 T21 Q22 K33 G47 T48 A49 T52 G168 T1 S20 T21 Q22 K33 G47 T48 A49 T52 G168 3.4.25.1 P25043 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4hnp H 2.80 BS02 VNK N 1 H114 H116 H114 H116 3.4.25.1 P25043 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4hnp I 2.80 BS01 ONK H 1 D124 I126 D124 I126 3.4.25.1 P25451 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 4hnp K 2.80 BS01 VNK K 1 T1 R19 A20 T21 A27 K33 M45 G47 G48 A49 S96 Y170 T1 R19 A20 T21 A27 K33 M45 G47 G48 A49 S96 Y170 3.4.25.1 P30656 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4hnp N 2.80 BS01 VNK N 1 T1 R19 T20 T21 T22 K33 S46 G47 S48 A49 S168 T1 R19 T20 T21 T22 K33 S46 G47 S48 A49 S168 3.4.25.1 P38624 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4hnp V 2.80 BS01 ONK V 1 T1 S20 T21 Q22 K33 G45 G47 T48 A49 G168 T1 S20 T21 Q22 K33 G45 G47 T48 A49 G168 3.4.25.1 P25043 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4hnp V 2.80 BS02 VNK b 1 H114 H116 H114 H116 3.4.25.1 P25043 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4hnp W 2.80 BS01 ONK V 1 D124 I126 D124 I126 3.4.25.1 P25451 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 4hnp Y 2.80 BS01 VNK Y 1 T1 R19 A20 T21 A27 K33 G47 A49 S96 Y170 T1 R19 A20 T21 A27 K33 G47 A49 S96 Y170 3.4.25.1 P30656 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4hnp b 2.80 BS01 VNK b 1 T1 R19 T20 T21 T22 K33 R45 G47 S48 A49 S168 T1 R19 T20 T21 T22 K33 R45 G47 S48 A49 S168 3.4.25.1 P38624 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4hrc H 2.80 BS01 OV2 H 1 T1 R19 S20 T21 Q22 K33 G47 A49 G168 T1 R19 S20 T21 Q22 K33 G47 A49 G168 3.4.25.1 P25043 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4hrc I 2.80 BS01 OV2 H 1 R98 D124 R98 D124 3.4.25.1 P25451 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 4hrc K 2.80 BS01 OV2 K 1 T1 R19 A20 T21 A27 K33 G47 A49 S131 Y170 T1 R19 A20 T21 A27 K33 G47 A49 S131 Y170 3.4.25.1 P30656 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4hrc L 2.80 BS01 OV2 K 1 D126 P127 D126 P127 3.4.25.1 P23724 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 4hrc N 2.80 BS01 OV2 N 1 T1 R19 T20 T21 R45 G47 A49 T94 S129 S168 T1 R19 T20 T21 R45 G47 A49 T94 S129 S168 3.4.25.1 P38624 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4hrc V 2.80 BS01 OV2 V 1 T1 R19 S20 T21 Q22 C31 K33 G47 T48 A49 S129 G168 T1 R19 S20 T21 Q22 C31 K33 G47 T48 A49 S129 G168 3.4.25.1 P25043 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4hrc V 2.80 BS02 OV2 b 1 H114 H116 H114 H116 3.4.25.1 P25043 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4hrc W 2.80 BS01 OV2 V 1 D124 L125 I126 D124 L125 I126 3.4.25.1 P25451 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 4hrc Y 2.80 BS01 OV2 Y 1 T1 R19 A20 T21 A27 K33 M45 G47 A49 S131 Y170 T1 R19 A20 T21 A27 K33 M45 G47 A49 S131 Y170 3.4.25.1 P30656 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4hrc b 2.80 BS01 OV2 b 1 T1 R19 T20 T21 T22 K33 R45 G47 S48 A49 T94 S168 T1 R19 T20 T21 T22 K33 R45 G47 S48 A49 T94 S168 3.4.25.1 P38624 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4hrd H 2.80 BS01 OV1 H 1 T1 R19 S20 T21 Q22 G23 K33 G47 A49 T52 G168 T1 R19 S20 T21 Q22 G23 K33 G47 A49 T52 G168 3.4.25.1 P25043 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4hrd H 2.80 BS02 OV1 N 1 Y97 H114 H116 Y97 H114 H116 3.4.25.1 P25043 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4hrd I 2.80 BS01 OV1 H 1 R98 D124 I126 R98 D124 I126 3.4.25.1 P25451 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 4hrd K 2.80 BS01 OV1 K 1 T1 R19 A20 T21 A27 K33 G47 A49 S131 Y170 T1 R19 A20 T21 A27 K33 G47 A49 S131 Y170 3.4.25.1 P30656 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4hrd L 2.80 BS01 OV1 K 1 Y106 D126 Y106 D126 3.4.25.1 P23724 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 4hrd N 2.80 BS01 OV1 N 1 T1 R19 T20 T21 T22 R45 G47 S48 A49 S168 T1 R19 T20 T21 T22 R45 G47 S48 A49 S168 3.4.25.1 P38624 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4hrd V 2.80 BS01 OV1 V 1 T1 R19 S20 T21 Q22 K33 G45 G47 T48 A49 G168 T1 R19 S20 T21 Q22 K33 G45 G47 T48 A49 G168 3.4.25.1 P25043 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4hrd V 2.80 BS02 OV1 b 1 Y97 H114 H116 Y97 H114 H116 3.4.25.1 P25043 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4hrd W 2.80 BS01 OV1 V 1 R98 D124 I126 R98 D124 I126 3.4.25.1 P25451 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 4hrd Y 2.80 BS01 OV1 Y 1 T1 R19 A20 T21 A27 K33 G47 A49 S131 Y170 T1 R19 A20 T21 A27 K33 G47 A49 S131 Y170 3.4.25.1 P30656 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4hrd Z 2.80 BS01 OV1 Y 1 D126 P127 D126 P127 3.4.25.1 P23724 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 4hrd b 2.80 BS01 OV1 b 1 T1 R19 T20 T21 T22 R45 G47 S48 A49 S168 T1 R19 T20 T21 T22 R45 G47 S48 A49 S168 3.4.25.1 P38624 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4ik3 A 2.01 BS01 CA A 1 D322 D324 D326 T328 E333 D267 D269 D271 T273 E278 23549615 SSRRKWNKTGHAVRAIGRLSSLENVYIKADKQKNGIKANFKIRHNIEDGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYIQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNTRDQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGDGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT 4ik3 A 2.01 BS02 CA A 2 D358 D360 D362 T364 E369 D303 D305 D307 T309 E314 23549615 SSRRKWNKTGHAVRAIGRLSSLENVYIKADKQKNGIKANFKIRHNIEDGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYIQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNTRDQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGDGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT 4ik3 A 2.01 BS03 CA A 3 D395 D397 N399 Y401 E406 D340 D342 N344 Y346 E351 23549615 SSRRKWNKTGHAVRAIGRLSSLENVYIKADKQKNGIKANFKIRHNIEDGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYIQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNTRDQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGDGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT 4ik3 A 2.01 BS04 CA A 4 D431 D433 D435 Q437 E442 D376 D378 D380 Q382 E387 23549615 SSRRKWNKTGHAVRAIGRLSSLENVYIKADKQKNGIKANFKIRHNIEDGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYIQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNTRDQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGDGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT 4ik5 A 2.50 BS01 CA A 1 D322 D324 D326 T328 E333 D265 D267 D269 T271 E276 23549615 RRKWNKTGHAVRAIGRLSSLENVYIKADKQKNGIKANFKIRHNIEDGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYIQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNTRDQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGDGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT 4ik5 A 2.50 BS02 CA A 2 D358 D360 D362 T364 E369 D301 D303 D305 T307 E312 23549615 RRKWNKTGHAVRAIGRLSSLENVYIKADKQKNGIKANFKIRHNIEDGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYIQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNTRDQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGDGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT 4ik5 A 2.50 BS03 CA A 3 D395 D397 N399 Y401 E406 D338 D340 N342 Y344 E349 23549615 RRKWNKTGHAVRAIGRLSSLENVYIKADKQKNGIKANFKIRHNIEDGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYIQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNTRDQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGDGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT 4ik5 A 2.50 BS04 CA A 4 D431 D433 D435 Q437 E442 D374 D376 D378 Q380 E385 23549615 RRKWNKTGHAVRAIGRLSSLENVYIKADKQKNGIKANFKIRHNIEDGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYIQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNTRDQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGDGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT 4ik9 A 1.80 BS01 CA A 1 D322 D324 D326 T328 E333 D267 D269 D271 T273 E278 23549615 SSRRKWNKTGHAVRAIGRLSSLENVYIKADKQKNGIKANFKIRHNIEDGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYIQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNTRDQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGDGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT 4ik9 A 1.80 BS02 CA A 2 D358 D360 D362 T364 E369 D303 D305 D307 T309 E314 23549615 SSRRKWNKTGHAVRAIGRLSSLENVYIKADKQKNGIKANFKIRHNIEDGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYIQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNTRDQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGDGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT 4ik9 A 1.80 BS03 CA A 3 D395 D397 N399 Y401 E406 D340 D342 N344 Y346 E351 23549615 SSRRKWNKTGHAVRAIGRLSSLENVYIKADKQKNGIKANFKIRHNIEDGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYIQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNTRDQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGDGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT 4ik9 A 1.80 BS04 CA A 4 D431 D433 D435 Q437 E442 D376 D378 D380 Q382 E387 23549615 SSRRKWNKTGHAVRAIGRLSSLENVYIKADKQKNGIKANFKIRHNIEDGGVQLAYHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGITLSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYIQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNTRDQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGDGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT 4imb A 2.70 BS01 1ES A 1 V208 F226 G254 M276 H307 E309 V177 F195 G223 M245 H276 E278 4.3.3.2 P68175 KEILIEAPSYAPNSFTFDSTNKGFYTSVQDGRVIKYEGPNSGFVDFAYASPYWNKAFCENSTDAEKRPLCGRTYDISYNLQNNQLYIVDCYYHLSVVGSEGGHATQLATSVDGVPFKWLYAVTVDQRTGIVYFTDVSTLYDDRGVQQIMDTSDKTGRLIKYDPSTKETTLLLKELHVPGGAEVSADSSFVLVAEFLSHQIVKYWLEGPKKGTAEVLVKIPNPGNIKRNADGHFWVSSSEELDGNMHGRVDPKGIKFDEFGNILEVIPLPPPFAGEHFEQIQEHDGLLYIGTLFHGSVGILV 4iql A 1.94 BS01 FMN A 1 G17 G18 M19 V20 N68 S94 E136 A140 G141 G170 G171 Q190 G192 T193 E277 I278 G17 G18 M19 V20 N68 S94 E136 A140 G141 G170 G171 Q190 G192 T193 E277 I278 1.3.1.9 Q7MAW0 MNRICELLGIEHPIISGGMVWCSGWKLASAVSNCGGLGLIGAGSMHPDNLEHHIRSCKAATDKPFGVNVPLLYPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGREETTTLCLIPEVVDAVNIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSLKAVSPTRLLKNKFYQDVFAAEQRGASVEELRELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTEI 4iql A 1.94 BS02 NDP A 1 W21 C22 S23 G24 W25 K26 S44 M45 N49 H52 H53 S202 F267 W21 C22 S23 G24 W25 K26 S44 M45 N49 H52 H53 S202 F267 1.3.1.9 Q7MAW0 MNRICELLGIEHPIISGGMVWCSGWKLASAVSNCGGLGLIGAGSMHPDNLEHHIRSCKAATDKPFGVNVPLLYPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGREETTTLCLIPEVVDAVNIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSLKAVSPTRLLKNKFYQDVFAAEQRGASVEELRELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTEI 4iql A 1.94 BS03 NDP A 2 W21 G43 S44 M45 H46 Y73 P74 E75 R259 G260 K263 W21 G43 S44 M45 H46 Y73 P74 E75 R259 G260 K263 1.3.1.9 Q7MAW0 MNRICELLGIEHPIISGGMVWCSGWKLASAVSNCGGLGLIGAGSMHPDNLEHHIRSCKAATDKPFGVNVPLLYPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGREETTTLCLIPEVVDAVNIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSLKAVSPTRLLKNKFYQDVFAAEQRGASVEELRELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTEI 4iql B 1.94 BS01 FMN B 1 G17 G18 M19 V20 N68 S94 E136 A140 G141 G170 G171 Q190 G192 T193 E277 I278 G17 G18 M19 V20 N68 S94 E136 A140 G141 G170 G171 Q190 G192 T193 E277 I278 1.3.1.9 Q7MAW0 MNRICELLGIEHPIISGGMVWCSGWKLASAVSNCGGLGLIGAGSMHPDNLEHHIRSCKAATDKPFGVNVPLLYPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGREETTTLCLIPEVVDAVNIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSLKAVSPTRLLKNKFYQDVFAAEQRGASVEELRELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTEI 4iql B 1.94 BS02 NDP B 1 W21 S23 G24 W25 S44 M45 N49 H52 H53 S202 F267 W21 S23 G24 W25 S44 M45 N49 H52 H53 S202 F267 1.3.1.9 Q7MAW0 MNRICELLGIEHPIISGGMVWCSGWKLASAVSNCGGLGLIGAGSMHPDNLEHHIRSCKAATDKPFGVNVPLLYPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGREETTTLCLIPEVVDAVNIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSLKAVSPTRLLKNKFYQDVFAAEQRGASVEELRELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTEI 4iql B 1.94 BS03 NDP B 2 W21 G43 S44 M45 H46 Y73 P74 E75 R259 G260 K263 W21 G43 S44 M45 H46 Y73 P74 E75 R259 G260 K263 1.3.1.9 Q7MAW0 MNRICELLGIEHPIISGGMVWCSGWKLASAVSNCGGLGLIGAGSMHPDNLEHHIRSCKAATDKPFGVNVPLLYPEMDKIMEIIMREHVPVVVTSAGSPKVWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGREETTTLCLIPEVVDAVNIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSLKAVSPTRLLKNKFYQDVFAAEQRGASVEELRELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTEI 4ira A 2.20 BS01 FAD A 1 Q64 H142 R166 Q53 H131 R155 1.14.13.3 Q8YHT7 STVESKAYRDAMSHYAGAVQIVTTAGAAGRRGLTLTAACSVSDNPPTILICLQKIHEENRIFIENGVFAINTLAGPHQQLADAFSGRIGLTQDERFELAAWEILATGAPVLKGALAAFDCRVVSVQDHSTHHVLFGEVVGLSSHAEEEALIYLNRRYHKLEL 4ira A 2.20 BS02 FAD A 2 R42 T45 L46 T47 A48 C62 Q64 H67 F95 S96 L101 T102 Q103 R106 R31 T34 L35 T36 A37 C51 Q53 H56 F84 S85 L90 T91 Q92 R95 1.14.13.3 Q8YHT7 STVESKAYRDAMSHYAGAVQIVTTAGAAGRRGLTLTAACSVSDNPPTILICLQKIHEENRIFIENGVFAINTLAGPHQQLADAFSGRIGLTQDERFELAAWEILATGAPVLKGALAAFDCRVVSVQDHSTHHVLFGEVVGLSSHAEEEALIYLNRRYHKLEL 4irr A 2.48 BS01 UMP A 1 R51 C197 Q216 R217 S218 G219 D220 G224 N228 H258 Y260 R29 C175 Q194 R195 S196 G197 D198 G202 N206 H236 Y238 2.1.1.45 Q9Y052 QQVHLNQDEYKYLKQVEQILREGTRRDDRTGTGTISIFGMQSKYCLRNGTIPLLTTKRVYWKGVLEELLWFISGSTDGKLLMEKNVKIWEKNGDRAFLDNLGFTSREEGDLGPVYGFQWRHFGAKYVDCHTDYSGQGVDQLAEVIRQIKEQPDSRRIIMSAWNPSDLGQMVLPPCHTMCQFYVDNGELSCQLYQRSGDMGLGVPFNLASYGLLTHMIAKVCGLKPGTLVHTLGDAHVYSNHVDALKIQLDREPYAFPKIRFTRDVASIDDFTSDMIALDDYKCHPKIPMD 4irr A 2.48 BS02 UMP B 1 R177 R178 R155 R156 2.1.1.45 Q9Y052 QQVHLNQDEYKYLKQVEQILREGTRRDDRTGTGTISIFGMQSKYCLRNGTIPLLTTKRVYWKGVLEELLWFISGSTDGKLLMEKNVKIWEKNGDRAFLDNLGFTSREEGDLGPVYGFQWRHFGAKYVDCHTDYSGQGVDQLAEVIRQIKEQPDSRRIIMSAWNPSDLGQMVLPPCHTMCQFYVDNGELSCQLYQRSGDMGLGVPFNLASYGLLTHMIAKVCGLKPGTLVHTLGDAHVYSNHVDALKIQLDREPYAFPKIRFTRDVASIDDFTSDMIALDDYKCHPKIPMD 4irr B 2.48 BS01 UMP A 1 R177 R178 R155 R156 2.1.1.45 Q9Y052 QQVHLNQDEYKYLKQVEQILREGTRRDDRTGTGTISIFGMQSKYCLRNGTIPLLTTKRVYWKGVLEELLWFISGSTDGKLLMEKNVKIWEKNGDRAFLDNLGFTSREEGDLGPVYGFQWRHFGAKYVDCHTDYSGQGVDQLAEVIRQIKEQPDSRRIIMSAWNPSDLGQMVLPPCHTMCQFYVDNGELSCQLYQRSGDMGLGVPFNLASYGLLTHMIAKVCGLKPGTLVHTLGDAHVYSNHVDALKIQLDREPYAFPKIRFTRDVASIDDFTSDMIALDDYKCHPKIPMD 4irr B 2.48 BS02 UMP B 1 R51 C197 Q216 R217 S218 G219 D220 G224 N228 H258 Y260 R29 C175 Q194 R195 S196 G197 D198 G202 N206 H236 Y238 2.1.1.45 Q9Y052 QQVHLNQDEYKYLKQVEQILREGTRRDDRTGTGTISIFGMQSKYCLRNGTIPLLTTKRVYWKGVLEELLWFISGSTDGKLLMEKNVKIWEKNGDRAFLDNLGFTSREEGDLGPVYGFQWRHFGAKYVDCHTDYSGQGVDQLAEVIRQIKEQPDSRRIIMSAWNPSDLGQMVLPPCHTMCQFYVDNGELSCQLYQRSGDMGLGVPFNLASYGLLTHMIAKVCGLKPGTLVHTLGDAHVYSNHVDALKIQLDREPYAFPKIRFTRDVASIDDFTSDMIALDDYKCHPKIPMD 4irw A 1.40 BS01 PDC A 1 G38 N39 G38 N39 P22629 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.40 BS02 PDC A 2 N71 N72 Y73 R74 N75 N71 N72 Y73 R74 N75 P22629 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.40 BS03 PDC A 3 E34 E41 S42 E34 E41 S42 P22629 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.40 BS04 PDC A 4 E41 S42 R43 Y73 E41 S42 R43 Y73 P22629 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.40 BS05 PDC A 5 R74 N75 R74 N75 P22629 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.40 BS06 PDC A 6 N39 S102 L114 N39 S102 L114 P22629 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.40 BS07 PDC A 7 D26 R49 D26 R49 P22629 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.40 BS08 PDC A 8 A28 R49 A28 R49 P22629 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.40 BS09 BTN A 1 N13 L15 S17 Y33 S35 V37 N39 W69 A76 S78 T80 W82 W98 L100 D118 N13 L15 S17 Y33 S35 V37 N39 W69 A76 S78 T80 W82 W98 L100 D118 P22629 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4itk A 1.18 BS01 FES A 1 Y36 S37 C38 R39 G41 G42 C43 C46 L74 C76 Y36 S37 C38 R39 G41 G42 C43 C46 L74 C76 Q2HZ25 MFKVTFKTPKGEKTIDVEADKYLLDAAEEAGMDLPYSCRSGGCSTCCGKLESGTVDQSDQNMLDEDQLKQGFVLTCVAYPTSDIVILTDQESKLPIGGSENLYF 4iuf A 2.75 BS01 NUC B 1 D105 I107 L109 G110 L111 P112 W113 M132 Q134 K136 G146 F147 F149 R171 K176 P178 N179 D3 I5 L7 G8 L9 P10 W11 M30 Q32 K34 G44 F45 F47 R69 K74 P76 N77 Q13148 TSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPN 4ivv A 1.05 BS01 ZN A 1 H26 H133 D149 H28 H135 D151 3.5.1.28 P06653 ASMEINVSKLRTDLPQVGVQPYRQVHAHSTGNPHSTVQNEADYHWRKDPELGFFSHIVGNGAIMQVGPVDNGAWDVGGGWNAETYAAVELIESHSTKEEFMTDYRLYIELLRNLADEAGLPKTLDTGSLAGIKTHEYATNNQPNNHSDHVDPYPYLAKWGISREQFKHDIENGL 4ivz A 3.10 BS01 NUC C 1 R17 T23 Q24 R35 T36 S39 R43 T49 R16 T22 Q23 R34 T35 S38 R42 T48 Q8GGH0 ESFLLSKVSFVIKKIRLEKGMTQEDLAYKSNLDRTFISGIERNSRNLTIKSLELIMKGLEVSDVVFFEMLIKEILK 4ivz A 3.10 BS02 NUC D 1 L33 D34 T36 F37 R46 N47 L48 T49 S52 L32 D33 T35 F36 R45 N46 L47 T48 S51 Q8GGH0 ESFLLSKVSFVIKKIRLEKGMTQEDLAYKSNLDRTFISGIERNSRNLTIKSLELIMKGLEVSDVVFFEMLIKEILK 4ivz B 3.10 BS01 NUC C 1 L33 D34 R35 T36 F37 N47 L48 T49 S52 L32 D33 R34 T35 F36 N46 L47 T48 S51 Q8GGH0 ESFLLSKVSFVIKKIRLEKGMTQEDLAYKSNLDRTFISGIERNSRNLTIKSLELIMKGLEVSDVVFFEMLIKEILK 4ivz B 3.10 BS02 NUC D 1 R17 T23 Q24 R35 T36 S39 R43 N44 T49 R16 T22 Q23 R34 T35 S38 R42 N43 T48 Q8GGH0 ESFLLSKVSFVIKKIRLEKGMTQEDLAYKSNLDRTFISGIERNSRNLTIKSLELIMKGLEVSDVVFFEMLIKEILK 4ivz E 3.10 BS01 NUC G 1 K14 R17 T23 Q24 R35 T36 S39 R43 T49 K13 R16 T22 Q23 R34 T35 S38 R42 T48 Q8GGH0 ESFLLSKVSFVIKKIRLEKGMTQEDLAYKSNLDRTFISGIERNSRNLTIKSLELIMKGLEVSDVVFFEMLIKEILKH 4ivz E 3.10 BS02 NUC H 1 N32 L33 D34 T36 F37 R46 N47 L48 T49 S52 N31 L32 D33 T35 F36 R45 N46 L47 T48 S51 Q8GGH0 ESFLLSKVSFVIKKIRLEKGMTQEDLAYKSNLDRTFISGIERNSRNLTIKSLELIMKGLEVSDVVFFEMLIKEILKH 4ivz F 3.10 BS01 NUC G 1 L33 D34 T36 F37 R46 N47 L48 T49 S52 L32 D33 T35 F36 R45 N46 L47 T48 S51 Q8GGH0 ESFLLSKVSFVIKKIRLEKGMTQEDLAYKSNLDRTFISGIERNSRNLTIKSLELIMKGLEVSDVVFFEMLIKEILK 4ivz F 3.10 BS02 NUC H 1 R17 T23 Q24 R35 S39 R43 N44 T49 R16 T22 Q23 R34 S38 R42 N43 T48 Q8GGH0 ESFLLSKVSFVIKKIRLEKGMTQEDLAYKSNLDRTFISGIERNSRNLTIKSLELIMKGLEVSDVVFFEMLIKEILK 4iw3 A 2.70 BS01 MN A 1 H124 D126 H183 H118 D120 H177 Q88CM1 HPMLAAVVDDLATHGWSQQAHFLPADLVRALAAECRRRDAEGELNPAGVGRGATQEVRETIRGDQIQWIDPGQAEACDQYLAAMDQLRLAINQGLFLGLEDFECHFALYPPGAFYRRHLDRFRDDDRRMVSAVLYLNEGWQPHDGGQLRMFLADGVEHDVEPVAGCLVVFLSGEVPHEVLPAGRERLSLTGWFRRRGNDPF 4iw3 B 2.70 BS01 GDP B 1 D22 H23 G24 K25 T26 T27 N136 K137 D139 S174 A175 R176 D13 H14 G15 K16 T17 T18 N121 K122 D124 S157 A158 R159 Q88QP8 LPHVNVGTIGHVDHGKTTLTAALTRVCSEVFGSKIDSAPEEKARGITINTAHVEYNSTIRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLSRQVGVPYIVVFLNKADLVAELLELVEMEVRDLLSTYDFPGDDTPIIIGSARMALEGKDDNEMGTTAVKKLVETLDSYIPEPVRAIDQPFLMPIEDVFSISGRGTVVTGRIERGIVRVQDPLEIVGLRDTTTTTCTGVEMFRKLLDEGRAGENCGVLLRGTKRDDVERGQVLVKPGSVKPHTKFTAEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGNCELPEGVEMVMPGDNIQMTVTLIKTIAMEDGLRFAIREGGRTVGAGVVAKIIE 4iw3 B 2.70 BS02 MG B 1 K25 T26 C82 K16 T17 C67 Q88QP8 LPHVNVGTIGHVDHGKTTLTAALTRVCSEVFGSKIDSAPEEKARGITINTAHVEYNSTIRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLSRQVGVPYIVVFLNKADLVAELLELVEMEVRDLLSTYDFPGDDTPIIIGSARMALEGKDDNEMGTTAVKKLVETLDSYIPEPVRAIDQPFLMPIEDVFSISGRGTVVTGRIERGIVRVQDPLEIVGLRDTTTTTCTGVEMFRKLLDEGRAGENCGVLLRGTKRDDVERGQVLVKPGSVKPHTKFTAEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGNCELPEGVEMVMPGDNIQMTVTLIKTIAMEDGLRFAIREGGRTVGAGVVAKIIE 4iw3 K 2.70 BS01 MG K 1 T26 D81 C82 T17 D64 C65 Q88QP8 LPHVNVGTIGHVDHGKTTLTAALTRVCSEVFGKIDSAPEEKAGITINTAHVEYNSTIRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLSRQVGVPYIVVFLNKADLVAELLELVEMEVRDLLSTYDFPGDDTPIIIGSARMALEGKDDNEMGTTAVKKLVETLDSYIPEPVRAIDQPFLMPIEDVFSISGRGTVVTGRIERGIVRVQDPLEIVGLRDTTTTTCTGVEMFRKLLDEGRAGENCGVLLRGTKRDDVERGQVLVKPGSVKPHTKFTAEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGNCELPEGVEMVMPGDNIQMTVTLIKTIAMEDGLRFAIREGGRTVGAGVVAKIIE 4iw3 K 2.70 BS02 GDP K 1 V21 D22 H23 G24 K25 T26 T27 N136 K137 D139 L140 S174 A175 R176 V12 D13 H14 G15 K16 T17 T18 N119 K120 D122 L123 S155 A156 R157 Q88QP8 LPHVNVGTIGHVDHGKTTLTAALTRVCSEVFGKIDSAPEEKAGITINTAHVEYNSTIRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLSRQVGVPYIVVFLNKADLVAELLELVEMEVRDLLSTYDFPGDDTPIIIGSARMALEGKDDNEMGTTAVKKLVETLDSYIPEPVRAIDQPFLMPIEDVFSISGRGTVVTGRIERGIVRVQDPLEIVGLRDTTTTTCTGVEMFRKLLDEGRAGENCGVLLRGTKRDDVERGQVLVKPGSVKPHTKFTAEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGNCELPEGVEMVMPGDNIQMTVTLIKTIAMEDGLRFAIREGGRTVGAGVVAKIIE 4iw3 J 2.70 BS01 MN J 1 H124 D126 H183 H118 D120 H177 Q88CM1 HPMLAAVVDDLATHGWSQQAHFLPADLVRALAAECRRRDAEGELNPAGVGRGATQEVRETIRGDQIQWIDPGQAEACDQYLAAMDQLRLAINQGLFLGLEDFECHFALYPPGAFYRRHLDRFRDDDRRMVSAVLYLNEGWQPHDGGQLRMFLADGVEHDVEPVAGCLVVFLSGEVPHEVLPAGRERLSLTGWFRRRGNDPF 4iwt A 2.60 BS01 CHT A 1 W186 S212 Y214 W14 S40 Y42 3.5.1.28 J1UPV3 SAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATGWKKIADKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK 4iwt A 2.60 BS02 CHT A 2 W220 W228 E275 W48 W56 E103 3.5.1.28 J1UPV3 SAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATGWKKIADKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK 4iwt A 2.60 BS03 CHT A 3 W241 W248 Y264 Y269 M278 W69 W76 Y92 Y97 M106 3.5.1.28 J1UPV3 SAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATGWKKIADKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK 4iwt A 2.60 BS04 CHT A 4 F199 W206 Y229 M237 E254 F27 W34 Y57 M65 E82 3.5.1.28 J1UPV3 SAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATGWKKIADKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK 4iwt A 2.60 BS05 CHT A 5 W261 W268 Y293 W89 W96 Y121 3.5.1.28 J1UPV3 SAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATGWKKIADKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK 4iwt B 2.60 BS01 CHT B 1 W186 S212 Y214 W14 S40 Y42 3.5.1.28 J1UPV3 SAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATGWKKIADKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK 4iwt B 2.60 BS02 CHT B 2 W220 M257 E275 W48 M85 E103 3.5.1.28 J1UPV3 SAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATGWKKIADKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK 4iwt B 2.60 BS03 CHT B 3 W241 W248 Y269 W69 W76 Y97 3.5.1.28 J1UPV3 SAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATGWKKIADKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK 4iwt B 2.60 BS04 CHT B 4 F199 W206 Y229 M237 E254 F27 W34 Y57 M65 E82 3.5.1.28 J1UPV3 SAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATGWKKIADKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK 4iwt B 2.60 BS05 CHT B 5 W261 Y293 W89 Y121 3.5.1.28 J1UPV3 SAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSDRWKKHTDGNWYYFDQSGEMATGWKKIADKWYYFDVEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK 4ixd A 1.80 BS01 MG A 1 S139 S141 D239 S12 S14 D112 P20701 GNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVI 4ixd A 1.80 BS02 1HV A 1 Y166 I235 Y257 I259 L298 E301 L302 K305 Y39 I108 Y130 I132 L171 E174 L175 K178 P20701 GNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVI 4ixs B 2.29 BS01 CO3 B 1 Y112 N160 K210 E338 S339 L340 T354 R374 Y90 N138 K188 E316 S317 L318 T332 R352 4.4.1.1 Q5H4T8 LSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4ixz A 2.07 BS01 BCT A 1 Y112 N160 K210 S339 L340 T354 R374 Y99 N147 K197 S326 L327 T341 R361 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 A 1.70 BS01 SER A 1 Y112 R117 E338 Y99 R104 E325 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 A 1.70 BS02 0JO A 1 S87 G88 M89 Y112 E156 N160 D185 T187 S207 T209 K210 S339 L340 T354 R374 S74 G75 M76 Y99 E143 N147 D172 T174 S194 T196 K197 S326 L327 T341 R361 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 A 1.70 BS03 SER B 1 E57 Y58 R60 T61 N240 E44 Y45 R47 T48 N227 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 A 1.70 BS04 KOU B 1 Y58 R60 Y45 R47 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 B 1.70 BS01 SER A 1 Y58 R60 T61 N240 Y45 R47 T48 N227 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 B 1.70 BS02 0JO A 1 Y58 R60 Y45 R47 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 B 1.70 BS03 SER B 1 Y112 R117 E338 Y99 R104 E325 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 B 1.70 BS04 PYR B 1 Q234 F237 Q221 F224 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 B 1.70 BS05 KOU B 1 S87 G88 M89 Y112 E156 N160 D185 T187 S207 T209 K210 E338 S339 L340 T354 R374 S74 G75 M76 Y99 E143 N147 D172 T174 S194 T196 K197 E325 S326 L327 T341 R361 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 C 1.70 BS01 SER C 1 Y112 R117 E338 Y99 R104 E325 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 C 1.70 BS02 KOU C 1 S87 G88 M89 Y112 E156 N160 D185 T187 S207 T209 K210 E338 S339 L340 T354 R374 S74 G75 M76 Y99 E143 N147 D172 T174 S194 T196 K197 E325 S326 L327 T341 R361 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 C 1.70 BS03 SER D 1 E57 Y58 R60 T61 N240 E44 Y45 R47 T48 N227 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 C 1.70 BS04 KOU D 1 Y58 R60 Y45 R47 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iy7 D 1.70 BS01 SER C 1 E57 Y58 R60 T61 N240 E44 Y45 R47 T48 N227 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQ 4iy7 D 1.70 BS02 KOU C 1 Y58 R60 Y45 R47 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQ 4iy7 D 1.70 BS03 SER D 1 Y112 R117 E338 Y99 R104 E325 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQ 4iy7 D 1.70 BS04 PYR D 1 N271 I379 E380 D381 L382 N258 I366 E367 D368 L369 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQ 4iy7 D 1.70 BS05 KOU D 1 S87 G88 M89 Y112 N160 D185 T187 F188 S207 T209 K210 S339 L340 T354 R374 S74 G75 M76 Y99 N147 D172 T174 F175 S194 T196 K197 S326 L327 T341 R361 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQ 4iyg A 2.70 BS01 1HU A 1 Y151 V208 F226 E309 Y120 V177 F195 E278 4.3.3.2 P68175 KEILIEAPSYAPNSFTFDSTNKGFYTSVQDGRVIKYEGPNSGFVDFAYASPYWNKAFCENSTDAEKRPLCGRTYDISYNLQNNQLYIVDCYYHLSVVGSEGGHATQLATSVDGVPFKWLYAVTVDQRTGIVYFTDVSTLYDDRGVQQIMDTSDKTGRLIKYDPSTKETTLLLKELHVPGGAEVSADSSFVLVAEFLSHQIVKYWLEGPKKGTAEVLVKIPNPGNIKRNADGHFWVSSSEELDGNMHGRVDPKGIKFDEFGNILEVIPLPPPFAGEHFEQIQEHDGLLYIGTLFHGSVGILVY 4iyo A 1.80 BS01 SER A 1 Y112 R117 E338 Y99 R104 E325 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iyo A 1.80 BS02 0JO A 1 S87 G88 M89 Y112 N160 D185 T187 F188 S207 T209 K210 S339 L340 T354 R374 S74 G75 M76 Y99 N147 D172 T174 F175 S194 T196 K197 S326 L327 T341 R361 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iyo A 1.80 BS03 SER B 1 E57 Y58 R60 T61 N240 E44 Y45 R47 T48 N227 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iyo B 1.80 BS01 SER A 1 Y58 R60 T61 N240 Y45 R47 T48 N227 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iyo B 1.80 BS02 0JO A 1 Y58 R60 Y45 R47 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iyo B 1.80 BS03 SER B 1 Y112 R117 E338 Y99 R104 E325 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iyo B 1.80 BS04 NAK B 1 Y112 N160 K210 S339 L340 T354 R374 Y99 N147 K197 S326 L327 T341 R361 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iyo B 1.80 BS05 PYR B 1 Q234 F237 Q221 F224 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iyo C 1.80 BS01 SER C 1 Y112 R117 E338 Y99 R104 E325 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iyo C 1.80 BS02 NAK C 1 Y112 N160 K210 S339 L340 T354 R374 Y99 N147 K197 S326 L327 T341 R361 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iyo C 1.80 BS03 SER D 1 Y58 R60 T61 N240 Y45 R47 T48 N227 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALV 4iyo D 1.80 BS01 SER C 1 Y58 R60 T61 N240 Y45 R47 T48 N227 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQN 4iyo D 1.80 BS02 SER D 1 Y112 R117 E338 Y99 R104 E325 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQN 4iyo D 1.80 BS03 SER D 2 Y112 N160 K210 S339 L340 T354 R374 Y99 N147 K197 S326 L327 T341 R361 4.4.1.1 Q5H4T8 ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQN 4j9c A 1.05 BS01 III B 1 Y70 S75 D77 T79 N94 E98 W99 W110 P112 N114 Y115 Y8 S13 D15 T17 N32 E36 W37 W48 P50 N52 Y53 2.7.10.2 P00519 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQTGEWCEAQTKNGQGWVPSNYITPVN 4j9d A 1.50 BS01 III B 1 Y70 F72 S75 D77 T79 N94 E98 W99 W110 P112 Y115 Y6 F8 S11 D13 T15 N30 E34 W35 W46 P48 Y51 2.7.10.2 P00519 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSAYITPVN 4j9d C 1.50 BS01 III D 1 Y70 F72 S75 D77 N78 T79 N94 E98 W99 W110 P112 A114 Y115 Y6 F8 S11 D13 N14 T15 N30 E34 W35 W46 P48 A50 Y51 2.7.10.2 P00519 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSAYITPVN 4j9d E 1.50 BS01 III F 1 Y70 F72 S75 D77 T79 N94 E98 W99 W110 P112 A114 Y115 Y9 F11 S14 D16 T18 N33 E37 W38 W49 P51 A53 Y54 2.7.10.2 P00519 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSAYITPVN 4j9e A 1.40 BS01 III B 1 Y70 F72 S75 D77 T79 N94 E98 W99 W110 P112 A114 Y115 Y6 F8 S11 D13 T15 N30 E34 W35 W46 P48 A50 Y51 2.7.10.2 P00519 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSAYITPVN 4j9e C 1.40 BS01 III D 1 Y70 S75 D77 N78 T79 N94 E98 W99 W110 P112 A114 Y115 Y6 S11 D13 N14 T15 N30 E34 W35 W46 P48 A50 Y51 2.7.10.2 P00519 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSAYITPVN 4j9e E 1.40 BS01 III F 1 Y70 F72 S75 D77 T79 N94 E98 W99 W110 P112 A114 Y115 Y7 F9 S12 D14 T16 N31 E35 W36 W47 P49 A51 Y52 2.7.10.2 P00519 NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSAYITPVN 4j9f A 1.09 BS01 III B 1 Y70 F72 S75 D77 T79 N94 E98 W99 W110 P112 N114 Y115 Y12 F14 S17 D19 T21 N36 E40 W41 W52 P54 N56 Y57 2.7.10.2 P00519 MENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 4j9f C 1.09 BS01 III D 1 Y70 F72 S75 D77 N78 T79 N94 E98 W99 W110 P112 N114 Y115 Y7 F9 S12 D14 N15 T16 N31 E35 W36 W47 P49 N51 Y52 2.7.10.2 P00519 NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 4j9f E 1.09 BS01 III F 1 Y70 S75 D77 T79 N94 E98 W99 W110 P112 N114 Y115 Y9 S14 D16 T18 N33 E37 W38 W49 P51 N53 Y54 2.7.10.2 P00519 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNS 4j9g A 1.80 BS01 III B 1 Y70 F72 S75 G76 T79 N94 E98 W99 W110 P112 N114 Y115 Y8 F10 S13 G14 T17 N32 E36 W37 W48 P50 N52 Y53 2.7.10.2 P00519 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 4j9g C 1.80 BS01 III D 1 Y70 F72 S75 G76 D77 N78 T79 N94 E98 W99 W110 P112 N114 Y115 Y8 F10 S13 G14 D15 N16 T17 N32 E36 W37 W48 P50 N52 Y53 2.7.10.2 P00519 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPV 4j9g E 1.80 BS01 III F 1 Y70 F72 S75 G76 D77 N78 T79 N94 E98 W99 W110 P112 N114 Y115 Y8 F10 S13 G14 D15 N16 T17 N32 E36 W37 W48 P50 N52 Y53 2.7.10.2 P00519 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPV 4j9h A 1.70 BS01 III G 1 Y70 F72 S75 D77 T79 N94 E98 W99 W110 P112 N114 Y115 Y9 F11 S14 D16 T18 N33 E37 W38 W49 P51 N53 Y54 2.7.10.2 P00519 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 4j9h B 1.70 BS01 III H 1 Y70 S75 D77 N78 T79 N94 E98 W99 W110 P112 N114 Y115 Y7 S12 D14 N15 T16 N31 E35 W36 W47 P49 N51 Y52 2.7.10.2 P00519 NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPV 4j9h C 1.70 BS01 III L 1 Y70 S75 G76 D77 N78 T79 N94 E98 W99 W110 P112 N114 Y115 Y7 S12 G13 D14 N15 T16 N31 E35 W36 W47 P49 N51 Y52 2.7.10.2 P00519 NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPV 4j9h D 1.70 BS01 III K 1 Y70 S75 D77 N78 T79 N94 E98 W99 W110 P112 N114 Y115 Y7 S12 D14 N15 T16 N31 E35 W36 W47 P49 N51 Y52 2.7.10.2 P00519 NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 4j9h E 1.70 BS01 III J 1 Y70 F72 S75 D77 T79 N94 E98 W99 W110 P112 N114 Y115 Y9 F11 S14 D16 T18 N33 E37 W38 W49 P51 N53 Y54 2.7.10.2 P00519 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 4j9h F 1.70 BS01 III I 1 Y70 F72 S75 N78 T79 N94 E98 W99 W110 P112 N114 Y115 Y7 F9 S12 N15 T16 N31 E35 W36 W47 P49 N51 Y52 2.7.10.2 P00519 NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPV 4j9i A 2.20 BS01 III B 1 Y70 S75 D77 T79 N94 E98 W99 W110 P112 Y115 Y6 S11 D13 T15 N30 E34 W35 W46 P48 Y51 2.7.10.2 P00519 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 4j9i C 2.20 BS01 III D 1 Y70 F72 S75 N78 T79 N94 E98 W99 W110 P112 N114 Y115 Y6 F8 S11 N14 T15 N30 E34 W35 W46 P48 N50 Y51 2.7.10.2 P00519 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 4j9i E 2.20 BS01 III F 1 Y70 S75 D77 T79 N94 E98 W99 W110 P112 N114 Y115 Y7 S12 D14 T16 N31 E35 W36 W47 P49 N51 Y52 2.7.10.2 P00519 NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 4jdh A 2.00 BS01 III B 1 G330 S331 Q358 R359 L362 T404 D440 K442 S443 D444 F461 S474 L475 V476 G477 T478 P479 Y480 W481 R489 E507 P520 L521 M524 G31 S32 Q59 R60 L63 T105 D141 K143 S144 D145 F162 S175 L176 V177 G178 T179 P180 Y181 W182 R190 E208 P221 L222 M225 2.7.11.1 O96013 24374310 SHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 4jdi A 1.85 BS01 III B 1 G330 S331 T404 D440 K442 S443 D444 F461 V476 G477 T478 P479 Y480 W481 E507 E512 F516 N517 L521 M524 G31 S32 T105 D141 K143 S144 D145 F162 V177 G178 T179 P180 Y181 W182 E208 E213 F217 N218 L222 M225 2.7.11.1 O96013 24374310 SHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 4jdi A 1.85 BS02 ANP A 1 I327 G328 G330 S331 T332 G333 V335 A348 K350 M395 E396 F397 L398 D444 L447 D458 I28 G29 G31 S32 T33 G34 V36 A49 K51 M96 E97 F98 L99 D145 L148 D159 2.7.11.1 O96013 24374310 SHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 4jdj A 2.30 BS01 III B 1 S331 T332 Q358 R359 L362 T404 D440 K442 S443 D444 V461 L475 V476 G477 T478 Y480 W481 E507 F516 L521 M524 S32 T33 Q59 R60 L63 T105 D141 K143 S144 D145 V162 L176 V177 G178 T179 Y181 W182 E208 F217 L222 M225 2.7.11.1 O96013 24374310 SHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGVCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 4jdk A 2.40 BS01 III B 1 S331 Q357 Q358 R359 L362 T404 D440 K442 S443 D444 V461 L475 V476 G477 T478 P479 Y480 W481 E507 F516 L521 M524 S32 Q58 Q59 R60 L63 T105 D141 K143 S144 D145 V162 L176 V177 G178 T179 P180 Y181 W182 E208 F217 L222 M225 2.7.11.1 O96013 24374310 SHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGVCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 4jfa A 2.60 BS01 TRP A 1 Y306 T307 G308 R309 G310 Q341 E346 K347 Y425 Q429 Q456 F460 Y62 T63 G64 R65 G66 Q97 E102 K103 Y181 Q185 Q212 F216 6.1.1.2 Q8IDW3 23776638 INYNKLIKEFGCSKITENHIKRIEKLTNSKAHHFIRRGIFFSHRDLDFLLNYYEQHKCFYIYTGRGPSSLSMHLGHLIPFYFCKYLQEAFNVPLVIQLSDDEKYLFNQNYSLEYINTLTNENVKDIISVGLNPELTFIFKNTEYAGYLYPTVLSIHKKTTLNQSMNVFGFNHSDNIGKISYPSFQIAPCFSQCFPNFLGKNIPCLVPQGIDQDPYFRLSRDIAVKMALHKPVVVHSVFMPGLQGVNNSVIFLTDTPEQIKNKINKYAFSGGGTTIQEHREKGGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTELVLKHQEKKKSLTDEEISYFFDPNKPSLQKF 4jfa B 2.60 BS01 TRP B 1 Y306 T307 G308 R309 G310 Q341 E346 K347 Y425 Q429 Q456 F460 Y62 T63 G64 R65 G66 Q97 E102 K103 Y181 Q185 Q212 F216 6.1.1.2 Q8IDW3 23776638 INYNKLIKEFGCSKITENHIKRIEKLTNSKAHHFIRRGIFFSHRDLDFLLNYYEQHKCFYIYTGRGPSSLSMHLGHLIPFYFCKYLQEAFNVPLVIQLSDDEKYLFNQNYSLEYINTLTNENVKDIISVGLNPELTFIFKNTEYAGYLYPTVLSIHKKTTLNQSMNVFGFNHSDNIGKISYPSFQIAPCFSQCFPNFLGKNIPCLVPQGIDQDPYFRLSRDIAVKMALHKPVVVHSVFMPGLNNSVIFLTDTPEQIKNKINKYAFSGGGTTIQEHREKGGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTELVLKHQEKKKSLTDEEISYFFDPNKPSLQKFKNMENLYFQ 4jfa C 2.60 BS01 TRP C 1 Y306 T307 G308 R309 G310 Q341 E346 K347 Q429 Q456 F460 Y62 T63 G64 R65 G66 Q97 E102 K103 Q185 Q212 F216 6.1.1.2 Q8IDW3 23776638 INYNKLIKEFGCSKITENHIKRIEKLTNSKAHHFIRRGIFFSHRDLDFLLNYYEQHKCFYIYTGRGPSSLSMHLGHLIPFYFCKYLQEAFNVPLVIQLSDDEKYLFNQNYSLEYINTLTNENVKDIISVGLNPELTFIFKNTEYAGYLYPTVLSIHKKTTLNQSMNVFGFNHSDNIGKISYPSFQIAPCFSQCFPNFLGKNIPCLVPQGIDQDPYFRLSRDIAVKMALHKPVVVHSVFMPGLNNSVIFLTDTPEQIKNKINKYAFSGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTELVLKHQEKKKSLTDEEISYFFDPNKPSLQKFKN 4jfa D 2.60 BS01 TRP D 1 Y306 T307 G308 R309 G310 Q341 S343 E346 K347 Y425 Q429 Q456 F460 Y62 T63 G64 R65 G66 Q97 S99 E102 K103 Y181 Q185 Q212 F216 6.1.1.2 Q8IDW3 23776638 INYNKLIKEFGCSKITENHIKRIEKLTNSKAHHFIRRGIFFSHRDLDFLLNYYEQHKCFYIYTGRGPSSLSMHLGHLIPFYFCKYLQEAFNVPLVIQLSDDEKYLFNQNYSLEYINTLTNENVKDIISVGLNPELTFIFKNTEYAGYLYPTVLSIHKKTTLNQSMNVFGFNHSDNIGKISYPSFQIAPCFSQCFPNFLGKNIPCLVPQGIDQDPYFRLSRDIAVKMALHKPVVVHSVFMPNNSVIFLTDTPEQIKNKINKYAFSGGGTTIQEHREKGGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIKKILIDVLTELVLKHQEKKKSLTDEEISYFFDPNKPSLQKF 4jp8 A 2.21 BS01 CA A 1 Q84 D124 L164 N166 I168 G169 V170 Q81 D121 L161 N163 I165 G166 V167 3.4.21.- P58502 24115021 NTIRVIVSVDKAKHNPHEVLGIGGHIVYQFKLIPAVVVDVPANAVGKLKKMPGVEKVEFDHQAVLLGKPSWLGGGSTQPAQTIPWGIERVKAPSVWSITDGSVSVIQVAVLDTGVDYDHPDLAANIAWCVSTLRGKVSTKLRDCADQNGHGTHVIGTIAALNNDIGVVGVAPGVQIYSVRVLDARGSGSYSDIAIGIEQAILGPDGVADKDGDGIIAGDPDDDAAEVISMSLGGPADDSYLYDMIIQAYNAGIVIVAASGNEGAPSPSYPAAYPEVIAVGAIDSNDNIASFSNRQPEVSAPGVDILSTYPDDSYETLMGTAMATPHVSGVVALIQAAYYQKYGKILPVGTFDDISKNTVRGILHITADDLGPTGWDADYGYGVVRAALAVQAALG 4jp8 A 2.21 BS02 CA A 2 L205 G206 D208 V210 A211 D226 L202 G203 D205 V207 A208 D223 3.4.21.- P58502 24115021 NTIRVIVSVDKAKHNPHEVLGIGGHIVYQFKLIPAVVVDVPANAVGKLKKMPGVEKVEFDHQAVLLGKPSWLGGGSTQPAQTIPWGIERVKAPSVWSITDGSVSVIQVAVLDTGVDYDHPDLAANIAWCVSTLRGKVSTKLRDCADQNGHGTHVIGTIAALNNDIGVVGVAPGVQIYSVRVLDARGSGSYSDIAIGIEQAILGPDGVADKDGDGIIAGDPDDDAAEVISMSLGGPADDSYLYDMIIQAYNAGIVIVAASGNEGAPSPSYPAAYPEVIAVGAIDSNDNIASFSNRQPEVSAPGVDILSTYPDDSYETLMGTAMATPHVSGVVALIQAAYYQKYGKILPVGTFDDISKNTVRGILHITADDLGPTGWDADYGYGVVRAALAVQAALG 4jp8 A 2.21 BS03 CA A 3 D212 D214 D216 I218 D222 D225 D209 D211 D213 I215 D219 D222 3.4.21.- P58502 24115021 NTIRVIVSVDKAKHNPHEVLGIGGHIVYQFKLIPAVVVDVPANAVGKLKKMPGVEKVEFDHQAVLLGKPSWLGGGSTQPAQTIPWGIERVKAPSVWSITDGSVSVIQVAVLDTGVDYDHPDLAANIAWCVSTLRGKVSTKLRDCADQNGHGTHVIGTIAALNNDIGVVGVAPGVQIYSVRVLDARGSGSYSDIAIGIEQAILGPDGVADKDGDGIIAGDPDDDAAEVISMSLGGPADDSYLYDMIIQAYNAGIVIVAASGNEGAPSPSYPAAYPEVIAVGAIDSNDNIASFSNRQPEVSAPGVDILSTYPDDSYETLMGTAMATPHVSGVVALIQAAYYQKYGKILPVGTFDDISKNTVRGILHITADDLGPTGWDADYGYGVVRAALAVQAALG 4jp8 A 2.21 BS04 CA A 4 D214 D216 D222 D224 D211 D213 D219 D221 3.4.21.- P58502 24115021 NTIRVIVSVDKAKHNPHEVLGIGGHIVYQFKLIPAVVVDVPANAVGKLKKMPGVEKVEFDHQAVLLGKPSWLGGGSTQPAQTIPWGIERVKAPSVWSITDGSVSVIQVAVLDTGVDYDHPDLAANIAWCVSTLRGKVSTKLRDCADQNGHGTHVIGTIAALNNDIGVVGVAPGVQIYSVRVLDARGSGSYSDIAIGIEQAILGPDGVADKDGDGIIAGDPDDDAAEVISMSLGGPADDSYLYDMIIQAYNAGIVIVAASGNEGAPSPSYPAAYPEVIAVGAIDSNDNIASFSNRQPEVSAPGVDILSTYPDDSYETLMGTAMATPHVSGVVALIQAAYYQKYGKILPVGTFDDISKNTVRGILHITADDLGPTGWDADYGYGVVRAALAVQAALG 4jp8 A 2.21 BS05 CA A 5 V108 Q110 A227 E229 V105 Q107 A224 E226 3.4.21.- P58502 24115021 NTIRVIVSVDKAKHNPHEVLGIGGHIVYQFKLIPAVVVDVPANAVGKLKKMPGVEKVEFDHQAVLLGKPSWLGGGSTQPAQTIPWGIERVKAPSVWSITDGSVSVIQVAVLDTGVDYDHPDLAANIAWCVSTLRGKVSTKLRDCADQNGHGTHVIGTIAALNNDIGVVGVAPGVQIYSVRVLDARGSGSYSDIAIGIEQAILGPDGVADKDGDGIIAGDPDDDAAEVISMSLGGPADDSYLYDMIIQAYNAGIVIVAASGNEGAPSPSYPAAYPEVIAVGAIDSNDNIASFSNRQPEVSAPGVDILSTYPDDSYETLMGTAMATPHVSGVVALIQAAYYQKYGKILPVGTFDDISKNTVRGILHITADDLGPTGWDADYGYGVVRAALAVQAALG 4jp8 A 2.21 BS06 CA A 6 D372 L373 G374 P375 T376 G377 D379 D369 L370 G371 P372 T373 G374 D376 3.4.21.- P58502 24115021 NTIRVIVSVDKAKHNPHEVLGIGGHIVYQFKLIPAVVVDVPANAVGKLKKMPGVEKVEFDHQAVLLGKPSWLGGGSTQPAQTIPWGIERVKAPSVWSITDGSVSVIQVAVLDTGVDYDHPDLAANIAWCVSTLRGKVSTKLRDCADQNGHGTHVIGTIAALNNDIGVVGVAPGVQIYSVRVLDARGSGSYSDIAIGIEQAILGPDGVADKDGDGIIAGDPDDDAAEVISMSLGGPADDSYLYDMIIQAYNAGIVIVAASGNEGAPSPSYPAAYPEVIAVGAIDSNDNIASFSNRQPEVSAPGVDILSTYPDDSYETLMGTAMATPHVSGVVALIQAAYYQKYGKILPVGTFDDISKNTVRGILHITADDLGPTGWDADYGYGVVRAALAVQAALG 4k0f A 2.19 BS01 HEM A 1 F113 Y126 Y140 L147 K151 V311 G315 T318 T322 L374 H378 P379 L383 R385 P462 F463 G464 H468 C470 I471 G472 F475 A476 F108 Y121 Y135 L142 K146 V306 G310 T313 T317 L369 H373 P374 L378 R380 P457 F458 G459 H463 C465 I466 G467 F470 A471 A6ZSR0 SIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKRNPEQKIGGRHHH 4k0f A 2.19 BS02 1YN A 1 A69 Y72 G73 Y126 F134 I139 Y140 F236 P238 G310 V311 G314 T318 H381 S382 F384 T507 S508 M509 A64 Y67 G68 Y121 F129 I134 Y135 F231 P233 G305 V306 G309 T313 H376 S377 F379 T502 S503 M504 A6ZSR0 SIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKRNPEQKIGGRHHH 4kpy A 2.41 BS01 NUC C 1 Y43 A170 Y171 R172 I173 R192 T201 L265 T266 L267 L279 S280 L281 R286 P412 M413 W415 R418 K422 S432 Q433 I434 L435 N436 H445 R446 N449 K457 E512 R513 P550 Q551 R580 R611 T613 P614 R615 Y642 A644 S645 A648 P650 R651 H657 R661 V685 Y43 A170 Y171 R172 I173 R192 T201 L261 T262 L263 L270 S271 L272 R277 P403 M404 W406 R409 K413 S423 Q424 I425 L426 N427 H436 R437 N440 K448 E503 R504 P541 Q542 R571 R602 T604 P605 R606 Y633 A635 S636 A639 P641 R642 H648 R652 V676 Q746M7 24374628 MNHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy A 2.41 BS02 NUC D 1 L267 E268 S328 K329 W415 H445 D478 A479 G481 R486 D546 K575 D590 V606 H607 R608 F610 F647 F649 D660 K664 L263 E264 S319 K320 W406 H436 D469 A470 G472 R477 D537 K566 D581 V597 H598 R599 F601 F638 F640 D651 K655 Q746M7 24374628 MNHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy A 2.41 BS03 NUC N 1 P44 R51 R114 D546 G547 R548 R574 K575 S576 G577 K618 P44 R51 R114 D537 G538 R539 R565 K566 S567 G568 K609 Q746M7 24374628 MNHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy A 2.41 BS04 DT A 1 N195 Y197 R200 W202 L217 P218 Y226 H227 R232 I254 P255 H256 N195 Y197 R200 W202 L217 P218 Y226 H227 R232 I250 P251 H252 Q746M7 24374628 MNHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy A 2.41 BS05 MN A 1 D478 D660 D469 D651 Q746M7 24374628 MNHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy A 2.41 BS06 MN A 2 D478 A479 D546 D469 A470 D537 Q746M7 24374628 MNHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy A 2.41 BS07 MN C 1 K457 V685 K448 V676 Q746M7 24374628 MNHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy B 2.41 BS01 NUC E 1 Y43 A170 Y171 R172 I173 R192 R194 T201 V264 L265 L267 L279 S280 L281 R286 P412 M413 W415 R418 K422 S432 Q433 I434 L435 N436 H445 R446 N449 K457 R486 E512 R513 P550 Q551 R580 F610 R611 G612 T613 P614 R615 Y642 A644 S645 A648 P650 R651 H657 R661 V685 Y41 A168 Y169 R170 I171 R190 R192 T199 V256 L257 L259 L269 S270 L271 R276 P402 M403 W405 R408 K412 S422 Q423 I424 L425 N426 H435 R436 N439 K447 R476 E502 R503 P540 Q541 R570 F600 R601 G602 T603 P604 R605 Y632 A634 S635 A638 P640 R641 H647 R651 V675 Q746M7 24374628 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLHEEELALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy B 2.41 BS02 NUC F 1 L267 E268 H271 E274 S328 K329 W415 H445 D478 A479 G480 G481 D546 K575 D590 V606 H607 R608 F610 F647 F649 D660 K664 R668 L259 E260 H263 E266 S318 K319 W405 H435 D468 A469 G470 G471 D536 K565 D580 V596 H597 R598 F600 F637 F639 D650 K654 R658 Q746M7 24374628 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLHEEELALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy B 2.41 BS03 NUC M 1 P44 A47 R51 R81 R114 D546 G547 R548 R574 K575 S576 G577 K618 P42 A45 R49 R79 R112 D536 G537 R538 R564 K565 S566 G567 K608 Q746M7 24374628 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLHEEELALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy B 2.41 BS04 DT B 1 Y197 R200 W202 L223 Y226 H227 R232 I254 P255 H256 Y195 R198 W200 L219 Y222 H223 R228 I246 P247 H248 Q746M7 24374628 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLHEEELALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy B 2.41 BS05 MN B 1 D478 A479 D546 D468 A469 D536 Q746M7 24374628 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLHEEELALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy B 2.41 BS06 MN B 2 D478 D660 D468 D650 Q746M7 24374628 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLHEEELALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4kpy B 2.41 BS07 MN E 1 K457 V685 K447 V675 Q746M7 24374628 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLTGLLVPVLTLEDLHEEELALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4l2o A 1.94 BS01 NAD A 1 T112 W113 N114 L119 E140 L141 V169 T186 G187 S188 V191 I194 E209 L210 G211 C243 R288 H289 E333 F335 L361 F401 T112 W113 N114 L119 E140 L141 V169 T186 G187 S188 V191 I194 E209 L210 G211 C243 R288 H289 E333 F335 L361 F401 1.2.1.5 P30838 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSP 4l2o A 1.94 BS02 1DD A 1 E61 Y65 Y115 N118 L119 M237 C243 I391 I394 T395 F401 H413 E61 Y65 Y115 N118 L119 M237 C243 I391 I394 T395 F401 H413 1.2.1.5 P30838 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSP 4l2o B 1.94 BS01 NAD B 1 T112 W113 N114 L119 E140 L141 V169 T186 G187 S188 V191 I194 E209 L210 G211 C243 H289 E333 F335 L361 F401 T112 W113 N114 L119 E140 L141 V169 T186 G187 S188 V191 I194 E209 L210 G211 C243 H289 E333 F335 L361 F401 1.2.1.5 P30838 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPA 4l2o B 1.94 BS02 1DD B 1 E61 E62 Y65 Y115 N118 L119 M237 C243 I391 I394 T395 F401 H413 E61 E62 Y65 Y115 N118 L119 M237 C243 I391 I394 T395 F401 H413 1.2.1.5 P30838 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPA 4l2o E 1.94 BS01 NAD E 1 T112 W113 N114 L119 E140 L141 V169 T172 T186 G187 S188 V191 I194 E209 L210 G211 C243 H289 E333 F335 L361 F401 T112 W113 N114 L119 E140 L141 V169 T172 T186 G187 S188 V191 I194 E209 L210 G211 C243 H289 E333 F335 L361 F401 1.2.1.5 P30838 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPA 4l2o E 1.94 BS02 1DD E 1 E61 Y65 Y115 N118 L119 M237 C243 I391 I394 F401 H413 E61 Y65 Y115 N118 L119 M237 C243 I391 I394 F401 H413 1.2.1.5 P30838 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPA 4l2o G 1.94 BS01 NAD G 1 T112 W113 N114 L119 E140 L141 V169 T186 G187 S188 V191 I194 E209 L210 G211 C243 H289 E333 F335 L361 F401 T112 W113 N114 L119 E140 L141 V169 T186 G187 S188 V191 I194 E209 L210 G211 C243 H289 E333 F335 L361 F401 1.2.1.5 P30838 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPA 4l2o G 1.94 BS02 1DD G 1 E61 E62 Y65 Y115 N118 L119 Q122 M237 C243 I391 I394 F401 H413 E61 E62 Y65 Y115 N118 L119 Q122 M237 C243 I391 I394 F401 H413 1.2.1.5 P30838 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPA 4l79 A 2.30 BS01 MG A 1 E556 N558 K561 N563 E546 N548 K551 N553 Q05096 EVKSSLLDNMIGVGDTVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSTPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLHKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFSDPEAESVLEVVAAVLKLGNIEFKPESDESKIKDKNELKEICELTSIDQVVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCRFLNDTTLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHALIKSLFPEGNPAKVNLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFSESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKGLNDIFEAQKIEWHED 4lj3 A 1.70 BS01 C2E A 1 Q127 E141 L143 V144 R145 P156 I160 I169 L176 N200 D262 D263 K286 G320 V321 E322 G340 Y341 P346 Q24 E38 L40 V41 R42 P53 I57 I66 L73 N97 D159 D160 K183 G217 V218 E219 G237 Y238 P243 3.1.4.- P21514 YHHIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMK 4lj3 A 1.70 BS02 CA A 1 E141 N200 E232 D262 E38 N97 E129 D159 3.1.4.- P21514 YHHIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMK 4lj3 A 1.70 BS03 CA A 2 D263 E319 D160 E216 3.1.4.- P21514 YHHIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMK 4lj3 A 1.70 BS04 HB0 A 1 V129 T138 G139 C140 H196 V230 E232 A260 F281 V317 F337 V26 T35 G36 C37 H93 V127 E129 A157 F178 V214 F234 3.1.4.- P21514 YHHIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMK 4lj3 B 1.70 BS01 C2E B 1 Q127 E141 L143 V144 R145 P156 I160 E164 I169 L176 N200 D262 D263 K286 G320 V321 E322 G340 Y341 P346 Q24 E38 L40 V41 R42 P53 I57 E61 I66 L73 N97 D159 D160 K183 G217 V218 E219 G237 Y238 P243 3.1.4.- P21514 YHHIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMK 4lj3 B 1.70 BS02 CA B 1 E141 N200 E232 D262 E38 N97 E129 D159 3.1.4.- P21514 YHHIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMK 4lj3 B 1.70 BS03 CA B 2 D263 D285 E319 D160 D182 E216 3.1.4.- P21514 YHHIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMK 4lj3 B 1.70 BS04 HB0 B 1 V129 T138 G139 C140 H196 V230 E232 A260 F281 V317 F337 V26 T35 G36 C37 H93 V127 E129 A157 F178 V214 F234 3.1.4.- P21514 YHHIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMK 4lkx A 1.92 BS01 III R 1 T30 S31 D32 Y33 A34 W47 Y53 I56 T57 G58 M95 G96 Y97 T30 S31 D32 Y33 A34 W48 Y54 I57 T58 G59 M99 G100 Y101 QVQLQESGPGLVKPSETLSLTCTVSGYSITSDYAWNWIRQPPGKGLEWIGSISYSGITGYNPSLKSRVTISRDTSKNQFSLKLSSVTAADTAVYYCARMGYDGLAYWGQGTLVTVSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKAEPKS 4lkx B 1.92 BS01 III R 1 H27D N30 Y32 K50 G91 V94 P96 H31 N35 Y37 K55 G96 V99 P101 DIVMTQTPLSLSVTPGQPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 4lly B 1.60 BS01 MG B 1 D38 K39 K42 D38 K39 K42 RIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQDKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGQPKAAPSVTLFPPSSEELQANKATLVCYISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAAWSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAP 4lrz A 2.32 BS01 ADP A 1 D30 D35 D37 H38 G78 A79 S80 L83 G121 A123 T129 M130 G177 R178 D191 P192 G193 D31 D36 D38 H39 G79 A80 S81 L84 G122 A124 T130 M131 G178 R179 D192 P193 G194 2.7.-.- P76014 24440518 GSSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE 4lrz A 2.32 BS02 MG A 1 D30 D35 D37 D31 D36 D38 2.7.-.- P76014 24440518 GSSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE 4lrz A 2.32 BS03 MG A 2 D35 D37 D36 D38 2.7.-.- P76014 24440518 GSSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE 4lrz B 2.32 BS01 ADP B 1 D30 D35 D37 H38 G78 A79 S80 L83 G121 A123 T129 M130 G177 R178 D191 P192 G193 D31 D36 D38 H39 G79 A80 S81 L84 G122 A124 T130 M131 G178 R179 D192 P193 G194 2.7.-.- P76014 24440518 GSSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE 4lrz B 2.32 BS02 MG B 1 D30 D35 D37 D31 D36 D38 2.7.-.- P76014 24440518 GSSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE 4lrz B 2.32 BS03 MG B 2 D35 D37 D36 D38 2.7.-.- P76014 24440518 GSSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE 4lrz C 2.32 BS01 ADP C 1 D30 D35 D37 H38 G78 A79 S80 L83 G121 A123 T129 M130 G177 R178 D191 P192 G193 D31 D36 D38 H39 G79 A80 S81 L84 G122 A124 T130 M131 G178 R179 D192 P193 G194 2.7.-.- P76014 24440518 GSSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE 4lrz C 2.32 BS02 MG C 1 D30 D35 D37 D31 D36 D38 2.7.-.- P76014 24440518 GSSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE 4lrz C 2.32 BS03 MG C 2 D35 D37 D36 D38 2.7.-.- P76014 24440518 GSSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE 4lrz D 2.32 BS01 ADP D 1 D30 D35 D37 H38 G78 A79 S80 L83 G121 A123 T129 M130 C131 G177 R178 D191 P192 G193 D31 D36 D38 H39 G79 A80 S81 L84 G122 A124 T130 M131 C132 G178 R179 D192 P193 G194 2.7.-.- P76014 24440518 GSSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE 4lrz D 2.32 BS02 MG D 1 D30 D35 D37 D31 D36 D38 2.7.-.- P76014 24440518 GSSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE 4lrz D 2.32 BS03 MG D 2 D35 D37 D36 D38 2.7.-.- P76014 24440518 GSSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE 4lsj A 2.35 BS01 III B 1 V575 K579 R585 L589 D590 Q592 M593 Q597 M752 E755 V50 K54 R60 L64 D65 Q67 M68 Q72 M219 E222 P04150 PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK 4lsj A 2.35 BS02 LSJ A 1 M560 L563 N564 L566 G567 Q570 W600 M601 M604 L608 F623 M639 L732 Y735 C736 T739 F749 M35 L38 N39 L41 G42 Q45 W75 M76 M79 L83 F98 M114 L199 Y202 C203 T206 F216 P04150 PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK 4lsj A 2.35 BS03 LSJ A 2 W712 F715 Y716 W179 F182 Y183 P04150 PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK 4lxj A 1.90 BS01 HEM A 1 F113 Y126 Y140 L147 K151 V311 G314 G315 T318 T322 L374 H378 P379 L383 R385 P462 F463 G464 H468 C470 I471 G472 F475 A476 F108 Y121 Y135 L142 K146 V306 G309 G310 T313 T317 L369 H373 P374 L378 R380 P457 F458 G459 H463 C465 I466 G467 F470 A471 1.14.13.70 P10614 SIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKRNPEQKIGGRHH 4lxj A 1.90 BS02 LAN A 1 Y126 L129 T130 F134 Y140 F236 F241 G310 G314 L380 H381 S382 L383 F384 F506 T507 S508 M509 Y121 L124 T125 F129 Y135 F231 F236 G305 G309 L375 H376 S377 L378 F379 F501 T502 S503 M504 1.14.13.70 P10614 SIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKRNPEQKIGGRHH 4lyk A 2.40 BS01 MG A 1 E141 N200 E232 D262 E35 N94 E126 D156 3.1.4.- P21514 IVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMK 4lyk A 2.40 BS02 HB0 A 1 V129 T138 G139 H196 V230 E232 F281 V317 F337 V23 T32 G33 H90 V124 E126 F175 V211 F231 3.1.4.- P21514 IVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMK 4lyk B 2.40 BS01 MG B 1 E141 N200 E232 D262 E35 N94 E126 D156 3.1.4.- P21514 IVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMK 4lyk B 2.40 BS02 HB0 B 1 V129 T138 G139 H196 V230 E232 F281 V317 F337 V23 T32 G33 H90 V124 E126 F175 V211 F231 3.1.4.- P21514 IVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVMK 4lyk C 2.40 BS01 MG C 1 E141 N200 E232 D262 E35 N94 E126 D156 3.1.4.- P21514 IVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVM 4lyk C 2.40 BS02 HB0 C 1 V129 T138 G139 H196 V230 E232 F281 V317 F337 V23 T32 G33 H90 V124 E126 F175 V211 F231 3.1.4.- P21514 IVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVM 4lyk D 2.40 BS01 MG D 1 E141 N200 E232 D262 E36 N95 E127 D157 3.1.4.- P21514 HIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVM 4lyk D 2.40 BS02 HB0 D 1 V129 T138 G139 H196 V230 E232 K283 V317 F337 V24 T33 G34 H91 V125 E127 K178 V212 F232 3.1.4.- P21514 HIVTPEAISLALENHEFKPWIQPVFCAQTGVLTGCEVLVRWEHPQTGIIPPDQFIPLAESSGLIVIMTRQLMKQTADILMPVKHLLPDNFHIGINVSAGCFLAAGFEKECLNLVNKLGNDKIKLVLELTERNPIPVTPEARAIFDSLHQHNITFALDDFGTGYATYRYLQAFPVDFIKIDKSFVQMASVDEISGHIVDNIVELARKPGLSIVAEGVETQEQADLMIGKGVHFLQGYLYSPPVPGNKFISEWVM 4m28 A 3.00 BS01 UPC A 1 L81 G83 G84 L85 G86 T87 Q162 G190 H191 D221 L76 G78 G79 L80 G81 T82 Q157 G185 H186 D216 2.7.7.9 Q4QDU3 KSLSAAAQACVKKMRDAKVNEACIRTFIAQHVMVSKGETGSIPDSAIMPVDSLDALDSLTIECDNAVLQSTVVLKLNGGLGTGMGLCDAKTLLEVKDGKTFLDFTALQVQYLRQHCSEHLRFMLMDSFNTSASTKSFLKARYPWLYQVFDSEVELMQNQVPKILQDTLEPAAWAENPAYEWAPPGHGDIYTALYGSGKLQELVEQGYRYMFVSNGDNLGATIDKRVLAYMEKEKIDFLMEVCRRTESDKKGGHLARQTVYVKGKDGQPDAEKRVLLLRESAQCPKADMESFQDINKYSFFNTNNLWIRLPVLLETMQEHGGTLPLPVIRNEKTVDSSNSASPKVYQLETAMGAAIAMFESASAIVVPRSRFAPVKTCADLLALRSDAYVVTDDFRLVLDDRCHGHPPVVDLDSAHYKMMNGFEKLVQHGVPSLVECKRVTVKGLVQFGAGNVLTGTVTIENTDSASAFVIPDGAKLNDTTASP 4m2a A 1.66 BS01 UPG A 1 L81 G83 G84 M130 Q162 G190 H191 N219 G220 G256 G257 E284 F305 N306 N308 F376 K380 L76 G78 G79 M125 Q157 G185 H186 N214 G215 G251 G252 E279 F300 N301 N303 F371 K375 2.7.7.9 Q4QDU3 KSLSAAAQACVKKMRDAKVNEACIRTFIAQHVMVSKGETGSIPDSAIMPVDSLDALDSLTIECDNAVLQSTVVLKLNGGLGTGMGLCDAKTLLEVKDGKTFLDFTALQVQYLRQHCSEHLRFMLMDSFNTSASTKSFLKARYPWLYQVFDSEVELMQNQVPKILQDTLEPAAWAENPAYEWAPPGHGDIYTALYGSGKLQELVEQGYRYMFVSNGDNLGATIDKRVLAYMEKEKIDFLMEVCRRTESDKKGGHLARQTVYVKGKDGQPDAEKRVLLLRESAQCPKADMESFQDINKYSFFNTNNLWIRLPVLLETMQEHGGTLPLPVIRNEKTVDSSNSASPKVYQLETAMGAAIAMFESASAIVVPRSRFAPVKTCADLLALRSDAYVVTDDFRLVLDDRCHGHPPVVDLDSAHYKMMNGFEKLVQHGVPSLVECKRVTVKGLVQFGAGNVLTGTVTIENTDSASAFVIPDGAKLNDTTASP 4m2b A 2.20 BS01 UPG A 1 L81 G83 G84 M130 Q162 G190 H191 N219 G220 K255 G256 G257 E284 F305 N306 T307 N308 F376 K380 L76 G78 G79 M125 Q157 G185 H186 N214 G215 K250 G251 G252 E279 F300 N301 T302 N303 F371 K375 2.7.7.9 Q4QDU3 KSLSAAAQACVKKMRDAKVNEACIRTFIAQHVMVSKGETGSIPDSAIMPVDSLDALDSLTIECDNAVLQSTVVLKLNGGLGTGMGLCDAKTLLEVKDGKTFLDFTALQVQYLRQHCSEHLRFMLMDSFNTSASTKSFLKARYPWLYQVFDSEVELMQNQVPKILQDTLEPAAWAENPAYEWAPPGHGDIYTALYGSGKLQELVEQGYRYMFVSNGDNLGATIDKRVLAYMEKEKIDFLMEVCRRTESDKKGGHLARQTVYVKGKDGQPDAEKRVLDLRESAQCPKADMESFQDINKYSFFNTNNLWIRLPVLLETMQEHGGTLPLPVIRNEKTVDSSNSASPKVYQLETAMGAAIAMFESASAIVVPRSRFAPVKTCADLLALRSDAYVVTDDFRLVLDDRCHGHPPVVDLDSAHYKMMNGFEKLVQHGVPSLVECKRVTVKGLVQFGAGNVLTGTVTIENTDSASAFVIPDGAKLNDTTASP 4m6r A 2.00 BS01 ZN A 1 H115 H117 H195 H97 H99 H177 4.2.1.109 Q96GX9 24367089 MDKEHPRYLIPELCKQFYHLGWVTGTGGGISLKHGDEIYIAPSGVQKERIQPEDMFVCDINEKDISGPSPSKKLKKSQCTPLFMNAYTMRGAGAVIHTHSKAAVMATLLFPGREFKITHQEMIKGIKKCTSGGYYRYDDMLVVPIIENTPEEKDLKDRMAHAMNEYPDSCAVLVRRHGVYVWGETWEKAKTMCECYDYLFDIAVSMKKVGLDPSQLPVGENGIV 4m6r B 2.00 BS01 ZN B 1 H115 H117 H195 H97 H99 H177 4.2.1.109 Q96GX9 24367089 MDKEHPRYLIPELCKQFYHLGWVTGTGGGISLKHGDEIYIAPSGVQKERIQPEDMFVCDINEKDISGPSPSKKLKKSQCTPLFMNAYTMRGAGAVIHTHSKAAVMATLLFPGREFKITHQEMIKGIKKCTSGGYYRYDDMLVVPIIENTPEEKDLKDRMAHAMNEYPDSCAVLVRRHGVYVWGETWEKAKTMCECYDYLFDIAVSMKKVGLDPSQLPVGENGIV 4m6r C 2.00 BS01 ZN C 1 H115 H117 H195 H97 H99 H177 4.2.1.109 Q96GX9 24367089 MDKEHPRYLIPELCKQFYHLGWVTGTGGGISLKHGDEIYIAPSGVQKERIQPEDMFVCDINEKDISGPSPSKKLKKSQCTPLFMNAYTMRGAGAVIHTHSKAAVMATLLFPGREFKITHQEMIKGIKKCTSGGYYRYDDMLVVPIIENTPEEKDLKDRMAHAMNEYPDSCAVLVRRHGVYVWGETWEKAKTMCECYDYLFDIAVSMKKVGLDPSQLPVGENGIV 4m6r D 2.00 BS01 ZN D 1 H115 H117 H195 H97 H99 H177 4.2.1.109 Q96GX9 24367089 MDKEHPRYLIPELCKQFYHLGWVTGTGGGISLKHGDEIYIAPSGVQKERIQPEDMFVCDINEKDISGPSPSKKLKKSQCTPLFMNAYTMRGAGAVIHTHSKAAVMATLLFPGREFKITHQEMIKGIKKCTSGGYYRYDDMLVVPIIENTPEEKDLKDRMAHAMNEYPDSCAVLVRRHGVYVWGETWEKAKTMCECYDYLFDIAVSMKKVGLDPSQLPVGEN 4man A 2.07 BS01 1Y1 A 1 A97 D100 F101 Y105 D108 F109 M112 V130 E133 L134 N140 W141 G142 R143 V145 A146 F150 Y199 A32 D35 F36 Y40 D43 F44 M47 V65 E68 L69 N75 W76 G77 R78 V80 A81 F85 Y134 P10415 23291630 GYDNREIVMKYIHYKLSQRGYEEVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGP 4man B 2.07 BS01 1Y1 B 1 A97 D100 F101 Y105 D108 F109 M112 V130 E133 L134 N140 W141 G142 R143 V145 A146 F150 Y199 A32 D35 F36 Y40 D43 F44 M47 V65 E68 L69 N75 W76 G77 R78 V80 A81 F85 Y134 P10415 23291630 GYDNREIVMKYIHYKLSQRGYEEVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGP 4mc3 A 1.50 BS01 28U A 1 S55 V179 I217 Q306 W309 H310 S52 V163 I201 Q283 W286 H287 4.2.3.- E4MYY0 24399794 FEIPDFYVPFPLECNPHLEEASRAMWEWIDANGLAPTERARDRMRRTGADLSGAYVWPRADLDTLTIGLKWIALTFRIDDQILPARMTAIDELRGTLHGLSPTARALGALWQETALGRPATWCDAFIGHFEAFLQTYTTEAGLNAHGAGLRLDDYLDRRMYSVGMPWLWDLDELRLPIFLPGSVRTCGPMNKLRRAGALHIALVNDVFSVYQHNAVTIIREAQGCSLQEAVDQVAVLVEAQLHTVLQARQELLEELDRQALPSRAREAAVDYAANVAANLSGQLVWH 4mc8 A 1.90 BS01 EPE A 1 S55 V59 T78 V179 L184 Q306 W309 S53 V57 T76 V166 L171 Q288 W291 4.2.3.- E4MYY0 24399794 EFEIPDFYVPFPLECNPHLEEASRAMWEWIDANGLAPTERARDRMRRTGADLSGAYVWPRADLDTLTIGLKWIALTFRIDDQIDEDPARMTAIDELRGTLHGLPVSGRSPTARALGALWQETALGRPATWCDAFIGHFEAFLQTYTTEAGLNLRLDDYLDRRMYSVGMPWLWDLDELRLPIFLPGSVRTCGPMNKLRRAGALHIALVNDVFSVEREQHNAVTIIREAQGCSLQEAVDQVAVLVEAQLHTVLQARQELLEELDRQALPSRAREAAVDYAANVAANLSGQLVWHSSVE 4mi8 A 2.10 BS01 III C 1 F48 Y52 V55 Y56 Y60 P62 A63 L64 K73 L74 S77 D81 N84 G86 R87 V89 V94 F47 Y51 V54 Y55 Y59 P61 A62 L63 K72 L73 S76 D80 N83 G85 R86 V88 V93 P89884 SHKKSGTYWATLITAFLKTVSKVEELDCVDSAVLVDVSKIITLTQEFRRHYDSVYRADYGPALKNWKRDLSKLFTSLFVDVINSGRIVGFFDVGRYVCEEVLCPGSWTEDHELLNDCMTHFFIENNLMNHFPLED 4mi8 B 2.10 BS01 III D 1 E47 F48 Y52 V55 Y56 Y60 A63 D70 K73 L74 S77 D81 N84 G86 R87 V94 E46 F47 Y51 V54 Y55 Y59 A62 D69 K72 L73 S76 D80 N83 G85 R86 V93 P89884 SHKKSGTYWATLITAFLKTVSKVEELDCVDSAVLVDVSKIITLTQEFRRHYDSVYRADYGPALKNWKRDLSKLFTSLFVDVINSGRIVGFFDVGRYVCEEVLCPGSWTEDHELLNDCMTHFFIENNLMNHFPLEDH 4mmh A 2.20 BS01 CA A 1 P189 H241 E245 P161 H213 E217 4.2.2.8 Q59289 ITRKDFDHINLEYSGLEKVNKAVAAGNYDDAAKALLAYYREKSKAREPDFSNAEKPADIRQPIDKVTREMADKALVHQFQPHKGYGYFDYGKDINWQMWPVKDNEVRWQLHRVKWWQAMALVYHATGDEKYAREWVYQYSDWARKNPLGLSQDNDKFVWRPLEVSDRVQSLPPTFSLFVNSPAFTPAFLMEFLNSYHQQADYLSTHYAEQGNHRLFEAQRNLFAGVSFPEFKDSPRWRQTGISVLNTEIKKQVYADGMQFELSPIYHVAAIDIFLKAYGSAKRVNLEKEFPQSYVQTVENMIMALISISLPDYNTPMFGDSWITDKNFRMAQFASWARVFPANQAIKYFATDGKQGKAPNFLSKALSNAGFYTFRSGWDKNATVMVLKASPPGEFHAQPDNGTFELFIKGRNFTPDAGVFVYSGDEAIMKLRNWYRQTRIHSTLTLDNQNMVITKARQNKWETGNNLDVLTYTNPSYPNLDHQRSVLFINKKYFLVIDRAIGEATGNLGVHWQLKEDSNPVFDKTKNRVYTTYRDGNNLMIQSLNADRTSLNEEEGKVSYVYNKELKRPAFVFEKPKKNAGTQNFVSIVYPYDGQKAPEISIRENKGNDFEKGKLNLTLTINGKQQLVLVPLEHHHH 4mmh A 2.20 BS02 CA A 2 G347 Q426 D444 G446 H469 G319 Q398 D416 G418 H441 4.2.2.8 Q59289 ITRKDFDHINLEYSGLEKVNKAVAAGNYDDAAKALLAYYREKSKAREPDFSNAEKPADIRQPIDKVTREMADKALVHQFQPHKGYGYFDYGKDINWQMWPVKDNEVRWQLHRVKWWQAMALVYHATGDEKYAREWVYQYSDWARKNPLGLSQDNDKFVWRPLEVSDRVQSLPPTFSLFVNSPAFTPAFLMEFLNSYHQQADYLSTHYAEQGNHRLFEAQRNLFAGVSFPEFKDSPRWRQTGISVLNTEIKKQVYADGMQFELSPIYHVAAIDIFLKAYGSAKRVNLEKEFPQSYVQTVENMIMALISISLPDYNTPMFGDSWITDKNFRMAQFASWARVFPANQAIKYFATDGKQGKAPNFLSKALSNAGFYTFRSGWDKNATVMVLKASPPGEFHAQPDNGTFELFIKGRNFTPDAGVFVYSGDEAIMKLRNWYRQTRIHSTLTLDNQNMVITKARQNKWETGNNLDVLTYTNPSYPNLDHQRSVLFINKKYFLVIDRAIGEATGNLGVHWQLKEDSNPVFDKTKNRVYTTYRDGNNLMIQSLNADRTSLNEEEGKVSYVYNKELKRPAFVFEKPKKNAGTQNFVSIVYPYDGQKAPEISIRENKGNDFEKGKLNLTLTINGKQQLVLVPLEHHHH 4mmi A 2.40 BS01 CA A 1 P189 A236 H241 E245 P161 A208 H213 E217 4.2.2.8 Q59289 VTRKDFDHINLEYSGLEKVNKAVAAGNYDDAAKALLAYYREKSKAREPDFSNAEKPADIRQPIDKVTREMADKALVHQFQPHKGYGYFDYGKDINWQMWPVKDNEVRWQLHRVKWWQAMALVYHATGDEKYAREWVYQYSDWARKNPLGLSQDNDKFVWRPLEVSDRVQSLPPTFSLFVNSPAFTPAFLMEFLNSYHQQADYLSTHYAEQGNHRLFEAQRNLFAGVSFPEFKDSPRWRQTGISVLNTEIKKQVYADGMQFELSPIYHVAAIDIFLKAYGSAKRVNLEKEFPQSYVQTVENMIMALISISLPDYNTPMFGDSWITDKNFRMAQFASWARVFPANQAIKYFATDGKQGKAPNFLSKALSNAGFYTFRSGWDKNATVMVLKASPPGEFHAQPDNGTFELFIKGRNFTPDAGVFVYSGDEAIMKLRNWYRQTRIHSTLTLDNQNMVITKARQNKWETGNNLDVLTYTNPSYPNLDHQRSVLFINKKYFLVIDRAIGEATGNLGVHWQLKEDSNPVFDKTKNRVYTTYRDGNNLMIQSLNADRTSLNEEEGKVSYVYNKELKRPAFVFEKPKKNAGTQNFVSIVYPYDGQKAPEISIRENKGNDFEKGKLNLTLTINGKQQLVSVPLEHHH 4mmi A 2.40 BS02 CA A 2 Q426 D444 G446 H469 Q398 D416 G418 H441 4.2.2.8 Q59289 VTRKDFDHINLEYSGLEKVNKAVAAGNYDDAAKALLAYYREKSKAREPDFSNAEKPADIRQPIDKVTREMADKALVHQFQPHKGYGYFDYGKDINWQMWPVKDNEVRWQLHRVKWWQAMALVYHATGDEKYAREWVYQYSDWARKNPLGLSQDNDKFVWRPLEVSDRVQSLPPTFSLFVNSPAFTPAFLMEFLNSYHQQADYLSTHYAEQGNHRLFEAQRNLFAGVSFPEFKDSPRWRQTGISVLNTEIKKQVYADGMQFELSPIYHVAAIDIFLKAYGSAKRVNLEKEFPQSYVQTVENMIMALISISLPDYNTPMFGDSWITDKNFRMAQFASWARVFPANQAIKYFATDGKQGKAPNFLSKALSNAGFYTFRSGWDKNATVMVLKASPPGEFHAQPDNGTFELFIKGRNFTPDAGVFVYSGDEAIMKLRNWYRQTRIHSTLTLDNQNMVITKARQNKWETGNNLDVLTYTNPSYPNLDHQRSVLFINKKYFLVIDRAIGEATGNLGVHWQLKEDSNPVFDKTKNRVYTTYRDGNNLMIQSLNADRTSLNEEEGKVSYVYNKELKRPAFVFEKPKKNAGTQNFVSIVYPYDGQKAPEISIRENKGNDFEKGKLNLTLTINGKQQLVSVPLEHHH 4myz A 1.50 BS01 III B 1 L51 L54 Q55 L58 I59 L61 K62 R65 L68 E69 E72 L27 L30 Q31 L34 I35 L37 K38 R41 L44 E45 E48 F4Y424 24183970 DITELSEIELEASVLQEIEALEKLISLSALQRALIALKDARSKLEKYE 4myz A 1.50 BS02 III B 2 I7 T8 E12 L15 S18 V19 E22 A25 L26 L29 L54 L61 K67 L68 Y71 I2 T3 E7 L10 S13 V14 E17 A20 L21 L24 L30 L37 K43 L44 Y47 F4Y424 24183970 DITELSEIELEASVLQEIEALEKLISLSALQRALIALKDARSKLEKYE 4myz A 1.50 BS03 III C 1 S11 I13 E14 A17 L20 E24 E27 K28 R56 S6 I8 E9 A12 L15 E19 E22 K23 R32 F4Y424 24183970 DITELSEIELEASVLQEIEALEKLISLSALQRALIALKDARSKLEKYE 4myz A 1.50 BS04 III C 2 I13 E16 S50 S52 I8 E11 S26 S28 F4Y424 24183970 DITELSEIELEASVLQEIEALEKLISLSALQRALIALKDARSKLEKYE 4myz B 1.50 BS01 III A 1 L51 L54 Q55 L58 I59 L61 K62 R65 L68 E72 T73 L30 L33 Q34 L37 I38 L40 K41 R44 L47 E51 T52 F4Y424 24183970 DITELSEIELEASVLQEIEALEKLIKEQSLSALQRALIALKDARSKLEKYET 4myz B 1.50 BS02 III A 2 I7 T8 L15 E16 S18 V19 E22 A25 L26 K28 L29 L54 A60 L61 A64 K67 L68 Y71 E72 I2 T3 L10 E11 S13 V14 E17 A20 L21 K23 L24 L33 A39 L40 A43 K46 L47 Y50 E51 F4Y424 24183970 DITELSEIELEASVLQEIEALEKLIKEQSLSALQRALIALKDARSKLEKYET 4myz C 1.50 BS01 III A 1 S11 I13 E14 E16 A17 L20 I23 E24 E27 K28 R56 S6 I8 E9 E11 A12 L15 I18 E19 E22 K23 R36 F4Y424 24183970 DITELSEIELEASVLQEIEALEKLIGKEQSLSALQRALIALKDARSKLEKY 4myz C 1.50 BS02 III A 3 E12 E16 S50 L51 S52 E7 E11 S30 L31 S32 F4Y424 24183970 DITELSEIELEASVLQEIEALEKLIGKEQSLSALQRALIALKDARSKLEKY 4myz C 1.50 BS03 III B 1 Q49 S50 Q29 S30 F4Y424 24183970 DITELSEIELEASVLQEIEALEKLIGKEQSLSALQRALIALKDARSKLEKY 4mz0 A 2.80 BS01 CA A 1 D306 G311 L312 V314 D304 G309 L310 V312 2.3.1.41 F4Y424 24183970 LKQEQEKEQSLSALQRALIALKDARSKLEKYETQSKEPIAIIGMSCRFPGGVDSPESFWQLLNDGVDAISEVPSNRWNINNYYDPDPDATGKISTRDGGFLSQIDGFDAPFFCISPREVQSLDPQQRLLLEVSWEAIERANIVPDQLFNSLTGVFIGIGSSDYLNQLATSEVPQAYWGTGNAPSAATGRLSYILGLTGPNLAVETACSSSLVSLHLACQSLRQQECNLALAGGVNLLLSPETSIIFSQAKMLSPDGRCKTFDASANGYVRGEGCGVIVLKRLSDAVANGDNVLAVIRGTAINQDGASGGLTVPNGPSQVAVIRKALSNGGVDPASVSYIEAHGTGTSLGDPIEVGAIGTVFGKTHSQEQPLIVGTAKTNIGHLEVAAGIAGLMKVVLQLQHQQIAPSLHFKQPNPYINWSQLPVQVSTQLTPWQTNGKSRIAGVSSFGFSGTNAHVVIEEAPKERAVYLLTLSAKTQAALDDLVNSYQNYLKNYPELRIADICYTANTCRSHFNNRLAVVASNQQELVEKLRQHQQGEEVTGIYSIELPNNSTAPKIALLFTGQGSQYVNMGRQLYQQAPVFRKALEQCNEILKSLLEILYPANLDQTAYTQPCLFALEYALFKLWQSWGIQPDVVMGHSVGEYVAATVAGVFSLEEGLKLIAARGRLMQQLPAGGEMVSVIASESKVLEIFKAMSLEEKVAIAAINGPESTVISGEAEAVGAIATHLESLSIKTKQLQVSHAFHSRLMEPMLAEFEAVAKQVTYSQPQISLISNVTGQQVGSEITSAEYWVNHVRQPVRFSESMTTLHQEGYELFLEIGPKPILLGMGRQCLPEGVGVWLPSLRPGVEAWQQMLQSLGQLYMKGIKVNWSGFDQDYACHKVAIPTYPFQRESYWI 4mz0 B 2.80 BS01 CA B 1 D306 G311 L312 V314 D295 G300 L301 V303 2.3.1.41 F4Y424 24183970 SLSALQRALIALKDARSKLEKYETQSKEPIAIIGMSCRFPGGVDSPESFWQLLNDGVDAISEVPSNRWNINNYYDPDPDATGKISTRDGGFLSQIDGFDAPFFCISPREVQSLDPQQRLLLEVSWEAIERANIVPDQLFNSLTGVFIGIGSSDYLNQLATSEVPQAYWGTGNAPSAATGRLSYILGLTGPNLAVETACSSSLVSLHLACQSLRQQECNLALAGGVNLLLSPETSIIFSQAKMLSPDGRCKTFDASANGYVRGEGCGVIVLKRLSDAVANGDNVLAVIRGTAINQDGASGGLTVPNGPSQVAVIRKALSNGGVDPASVSYIEAHGTGTSLGDPIEVGAIGTVFGKTHSQEQPLIVGTAKTNIGHLEVAAGIAGLMKVVLQLQHQQIAPSLHFKQPNPYINWSQLPVQVSTQLTPWQTNGKSRIAGVSSFGFSGTNAHVVIEEAPKRAVYLLTLSAKTQAALDDLVNSYQNYLKNYPELRIADICYTANTCRSHFNNRLAVVASNQQELVEKLRQHQQGEEVTGIYSIELPNNSTAPKIALLFTGQGSQYVNMGRQLYQQAPVFRKALEQTAYTQPCLFALEYALFKLWQSWGIQPDVVMGHSVGEYVAATVAGVFSLEEGLKLGEMVSVIASESKVLEIFKAMSLEEAIAAINGPESTVISGEAEAVGAIATHLESLSIKTKQQVSHAFHYSQPQISLISNVTGQQVYWVNHVRQPVRFSESMTTLHQEGYELFLEIGPKPILLGMGRQCLPEGVGVWLPSLRPGVEAWQQMLQSLGQLYMKGIKVNWSGFDQDYACHKVAIPTYPFQRESYWI 4n0x B 1.63 BS01 ZN B 1 H94 H96 H119 H92 H94 H117 4.2.1.1 P00918 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4n0x B 1.63 BS02 EVJ B 1 H94 H96 H119 V121 L198 T199 T200 W209 H92 H94 H117 V119 L195 T196 T197 W206 4.2.1.1 P00918 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4n3w A 1.90 BS01 III C 1 V1115 L1120 G1121 I1122 P1123 D1124 L1166 Y1167 N1168 R1169 V34 L39 G40 I41 P42 D43 L85 Y86 N87 R88 2.3.1.48 Q92793 24361270 KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCDDPSQPQTTKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCL 4n3w A 1.90 BS02 ZN A 1 C1199 C1200 H1291 C1294 C118 C119 H163 C166 2.3.1.48 Q92793 24361270 KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCDDPSQPQTTKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCL 4n3w A 1.90 BS03 ZN A 2 C1283 C1286 C1308 C1311 C155 C158 C180 C183 2.3.1.48 Q92793 24361270 KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCDDPSQPQTTKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCL 4n9y A 2.30 BS01 V3L A 1 P469 V475 V477 R478 V479 D480 F491 T493 P28 V34 V36 R37 V38 D39 F50 T52 3.2.1.143 O88622 PEKKWLGTPIEEMRKMPRCGIHLPSLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQQEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRRCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHTFLTERKLDVGKVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESS 4n9z A 1.90 BS01 V3L A 1 P469 V475 V477 R478 V479 D480 F491 T493 P28 V34 V36 R37 V38 D39 F50 T52 3.2.1.143 O88622 PEKKWLGTPIEEMRKMPRCGIHLPSLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEQIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRRCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHTFLTERKLDVGKVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESSA 4n9z B 1.90 BS01 V3L B 1 P469 V475 V477 R478 V479 D480 F491 T493 P28 V34 V36 R37 V38 D39 F50 T52 3.2.1.143 O88622 PEKKWLGTPIEEMRKMPRCGIHLPSLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEQIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRRCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHTFLTERKLDVGKVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESSA 4na0 A 2.40 BS01 AR6 A 1 T718 I719 E720 F731 N733 G738 V746 Q747 E748 E749 Y785 Y788 N862 G864 C865 G866 A867 F868 F895 T265 I266 E267 F278 N280 G285 V293 Q294 E295 E296 Y332 Y335 N409 G411 C412 G413 A414 F415 F442 3.2.1.143 O88622 KKWLGTPIEEMRKMPRCGIHLPSLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRRCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHTFLTERKLDVGKVYKLLLRYYNEECRNCPGPDIKLYPFIYHAVESS 4na0 B 2.40 BS01 AR6 B 1 T718 I719 E720 F731 A732 N733 G738 V746 Q747 E748 E749 Y785 Y788 N862 G864 C865 G866 A867 F868 F895 T265 I266 E267 F278 A279 N280 G285 V293 Q294 E295 E296 Y332 Y335 N409 G411 C412 G413 A414 F415 F442 3.2.1.143 O88622 KKWLGTPIEEMRKMPRCGIHLPSLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRRCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHTFLTERKLDVGKVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVES 4na0 C 2.40 BS01 AR6 C 1 I719 E720 F731 N733 G738 V746 Q747 E748 E749 Y788 N862 G864 G866 A867 F868 F895 I265 E266 F277 N279 G284 V292 Q293 E294 E295 Y334 N408 G410 G412 A413 F414 F441 3.2.1.143 O88622 KKWLGTPIEEMRKMPRCGIHLPSLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRRCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHTFLTERKLDVGKVYKLLLRYYNEECRNCSTGPDIKLYPFIYHAVESS 4na4 A 2.50 BS01 A1R A 1 T718 I719 E720 F731 N733 G738 V746 Q747 E748 E749 Y788 N862 G864 C865 G866 A867 F868 F895 T268 I269 E270 F281 N283 G288 V296 Q297 E298 E299 Y338 N412 G414 C415 G416 A417 F418 F445 3.2.1.143 O88622 KKWLGTPIEEMRKMPRCGIHLPSLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRRCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHTFLTERKLDVGKVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVES 4na4 B 2.50 BS01 A1R B 1 I719 E720 F731 N733 G738 V746 Q747 E748 E749 Y788 N862 G864 G866 A867 F868 F895 I258 E259 F270 N272 G277 V285 Q286 E287 E288 Y327 N401 G403 G405 A406 F407 F434 3.2.1.143 O88622 WLGTPIEEMRKMPRCGIHLPSLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRRCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHTFLTERKLDVGKVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVES 4na4 C 2.50 BS01 A1R C 1 I719 E720 F731 N733 G738 V746 Q747 E748 E749 Y788 N862 G864 C865 G866 A867 F868 F895 I268 E269 F280 N282 G287 V295 Q296 E297 E298 Y337 N411 G413 C414 G415 A416 F417 F444 3.2.1.143 O88622 KKWLGTPIEEMRKMPRCGIHLPSLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGVTGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDGSEKDDWQRRCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHTFLTERKLDVGKVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESS 4nak A 1.80 BS01 PBQ A 1 R157 V161 A202 A203 Q238 V239 L245 F249 S264 I265 V266 R73 V77 A118 A119 Q149 V150 L156 F160 S175 I176 V177 2.7.7.60 P69834 EKSVSVILLAGGPKQYIPLLGQPIALYSFFTFSRMPEVKEIVVVCDPFFRDIFEEYEESIDVDLSFAIPGKERQDSVYSGLQEIDVNSELVCIHDSARPLVNTEDVEKVLKDGSAVGAAVLGVPAKATIKEVNSDSLVVKTLWEMQTPQVIKPELLKKGFELVKSEGLEVTDDVSIVEYLKHPVYVSQGSYTNIKVTTPDDLLLAERIL 4nal A 1.80 BS01 H70 A 1 R157 V161 A202 A203 Q238 V239 I240 L245 F249 S264 I265 V266 R74 V78 A119 A120 Q151 V152 I153 L158 F162 S177 I178 V179 2.7.7.60 P69834 MEKSVSVILLAGGPKQYIPLLGQPIALYSFFTFSRMPEVKEIVVVCDPFFRDIFEEYEESIDVDLSFAIPGKERQDSVYSGLQEIDVNSELVCIHDSARPLVNTEDVEKVLKDGSAVGAAVLGVPAKATIKEVNSDSLVVKTTLWEMQTPQVIKPELLKKGFELVKSEGLEVTDDVSIVEYLKHPVYVSQGSYTNIKVTTPDDLLLAERILSE 4nan A 1.80 BS01 2JM A 1 V161 V204 Q238 V239 L245 I265 V266 V273 V76 V119 Q148 V149 L155 I175 V176 V183 2.7.7.60 P69834 EKSVSVILLAGPKQYIPLLGQPIALYSFFTFSRMPEVKEIVVVCDPFFRDIFEEYEESIDVDLSFAIPGKERQDSVYSGLQEIDVNSELVCIHDSARPLVNTEDVEKVLKDGSAVGAAVLGVPAKATIKEVNSDSLVVKTLWEMQTPQVIKPELLKKGFELVKSEGLEVTDDVSIVEYLKHPVYVSQGSYTNIKVTTPDDLLLAERIL 4nei A 1.85 BS01 ZN A 1 H415 D433 H464 H386 D404 H435 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNHGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYYQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVR 4nei B 1.85 BS01 ZN B 1 H415 D433 H464 H386 D404 H435 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNHGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYYQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVR 4nmn A 3.30 BS01 ADP A 1 P208 G209 G211 K212 T213 R246 L256 R260 R393 F428 T433 P196 G197 G199 K200 T201 R234 L244 R248 R381 F414 T419 O67450 24373746 PCDESAERAVLGSMLEDPENIPLVLEYLKEEDFCIDEHKLLFRVLTNLWSEYGNKLDFVLIKDHLEKKNLLQIDWLEELYEEAVSPDTLEEVCKIVKQRSAQRAIIQLGIELIHKGKENKDFHTLIEEAQSRIFSIAESSTQFYHVKDVAEEVIELIYKFKSSDRLVTGLPSGFTELDLKTTGFHPGDLIILAARPGMGKTAFMLSIIYNLAKDEGKPSAVFSLEMSKEQLVMRLLSMMSEVPLFKIRSGSISNEDLKKLEASAIELAKYDIYLDDTPALTTTDLRIRARKLRKEKEVEFVAVDYLQLLRPPVRKSPRQEEVAEVSRNLKALAKELRIPVMALAQLSREVEKRSDKRPQLADLRESGQIEQDADLILFLHRPEYYTKKPNEQGIAEVIIAKQRQGPTDIVKLAFIKEYTKFANLE 4nmn A 3.30 BS02 MG A 1 T213 E237 T201 E225 O67450 24373746 PCDESAERAVLGSMLEDPENIPLVLEYLKEEDFCIDEHKLLFRVLTNLWSEYGNKLDFVLIKDHLEKKNLLQIDWLEELYEEAVSPDTLEEVCKIVKQRSAQRAIIQLGIELIHKGKENKDFHTLIEEAQSRIFSIAESSTQFYHVKDVAEEVIELIYKFKSSDRLVTGLPSGFTELDLKTTGFHPGDLIILAARPGMGKTAFMLSIIYNLAKDEGKPSAVFSLEMSKEQLVMRLLSMMSEVPLFKIRSGSISNEDLKKLEASAIELAKYDIYLDDTPALTTTDLRIRARKLRKEKEVEFVAVDYLQLLRPPVRKSPRQEEVAEVSRNLKALAKELRIPVMALAQLSREVEKRSDKRPQLADLRESGQIEQDADLILFLHRPEYYTKKPNEQGIAEVIIAKQRQGPTDIVKLAFIKEYTKFANLE 4nmn B 3.30 BS01 ADP A 1 R417 Q418 R391 Q392 O67450 24373746 PCDESAERAVLGSMLEDPENIPLVLEYLKEEDFCIDEHKLLFRVLTNLWSEGNKLDFVLIKDHLEKKPIDWLEELYEEAVSPDTLEEVCKIVKQRSAQRAIIQLGIELIHKGKENKDFHTLIEEAQSRIFSIAESATSTQFYHVKDVAEEVIELIYKFKSSDRLVTGLPSGFTELDLKTTGFHPGDLIILAARPGMGKTAFMLSIIYNLAKDEGKPSAVFSLEMSKEQLVMRLLSMMSEVPLFKIRSGSISNEDLKKLEASAIELAKYDIYLDDTPALTTTDLRIRARKLRKEKEVEFVAVDYLQLLRPPVRKSPRQEEVAEVSRNLKALAKELRIPVMALAQLSKRPQLADLRESGQIEQDADLILFLHRPEYYTPEEQGIAEVIIAKQRQGPTDIVKLAFIKEYTKFANL 4nmn B 3.30 BS02 ADP B 1 G209 M210 G211 K212 T213 A214 R246 K430 T433 G195 M196 G197 K198 T199 A200 R232 K404 T407 O67450 24373746 PCDESAERAVLGSMLEDPENIPLVLEYLKEEDFCIDEHKLLFRVLTNLWSEGNKLDFVLIKDHLEKKPIDWLEELYEEAVSPDTLEEVCKIVKQRSAQRAIIQLGIELIHKGKENKDFHTLIEEAQSRIFSIAESATSTQFYHVKDVAEEVIELIYKFKSSDRLVTGLPSGFTELDLKTTGFHPGDLIILAARPGMGKTAFMLSIIYNLAKDEGKPSAVFSLEMSKEQLVMRLLSMMSEVPLFKIRSGSISNEDLKKLEASAIELAKYDIYLDDTPALTTTDLRIRARKLRKEKEVEFVAVDYLQLLRPPVRKSPRQEEVAEVSRNLKALAKELRIPVMALAQLSKRPQLADLRESGQIEQDADLILFLHRPEYYTPEEQGIAEVIIAKQRQGPTDIVKLAFIKEYTKFANL 4nmn B 3.30 BS03 MG B 1 T213 D316 T199 D302 O67450 24373746 PCDESAERAVLGSMLEDPENIPLVLEYLKEEDFCIDEHKLLFRVLTNLWSEGNKLDFVLIKDHLEKKPIDWLEELYEEAVSPDTLEEVCKIVKQRSAQRAIIQLGIELIHKGKENKDFHTLIEEAQSRIFSIAESATSTQFYHVKDVAEEVIELIYKFKSSDRLVTGLPSGFTELDLKTTGFHPGDLIILAARPGMGKTAFMLSIIYNLAKDEGKPSAVFSLEMSKEQLVMRLLSMMSEVPLFKIRSGSISNEDLKKLEASAIELAKYDIYLDDTPALTTTDLRIRARKLRKEKEVEFVAVDYLQLLRPPVRKSPRQEEVAEVSRNLKALAKELRIPVMALAQLSKRPQLADLRESGQIEQDADLILFLHRPEYYTPEEQGIAEVIIAKQRQGPTDIVKLAFIKEYTKFANL 4npk A 2.55 BS01 CA A 1 D401 D413 D460 E461 D462 D22 D34 D81 E82 D83 A0FGR8 24373768 FPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNVSNLDKVLTDIKADGLSSALLILYLDSARNLPSSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEK 4npk A 2.55 BS02 CA A 2 K400 D401 D460 D462 D467 K21 D22 D81 D83 D88 A0FGR8 24373768 FPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNVSNLDKVLTDIKADGLSSALLILYLDSARNLPSSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEK 4npk A 2.55 BS03 CA A 3 D462 P463 D464 D466 D83 P84 D85 D87 A0FGR8 24373768 FPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNVSNLDKVLTDIKADGLSSALLILYLDSARNLPSSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEK 4nuf A 2.80 BS01 III P 1 K1068 T1069 F1072 L1076 S1078 G1102 Q1105 P1166 K1167 A1170 Y1171 K1173 G1174 H1190 H1193 E1197 K384 T385 F388 L392 S394 G418 Q421 P455 K456 A459 Y460 K462 G463 H479 H482 E486 Q62227 24379397 KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAAPHRTCREALDVLAKTVAFLRNLPSFCHLPHDDQRRLLECCWGPLFLLGLAQDAVTFEVAEAQPSLAAVQWLQRCLESFWSLELGPKEYAYLKGTILFNPDVPGLRASCHIAHLQQEAHWALCEVLEPWYPASQGRLARILLMASTLRNIPGTLLVDLFFRPIMGDVDITELLEDMLLLR 4nuf A 2.80 BS02 MAL A 1 N14 D16 K17 W64 A65 D67 R68 E113 E155 P156 Y157 W232 W342 N12 D14 K15 W62 A63 D65 R66 E111 E153 P154 Y155 W230 W340 Q62227 24379397 KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAAPHRTCREALDVLAKTVAFLRNLPSFCHLPHDDQRRLLECCWGPLFLLGLAQDAVTFEVAEAQPSLAAVQWLQRCLESFWSLELGPKEYAYLKGTILFNPDVPGLRASCHIAHLQQEAHWALCEVLEPWYPASQGRLARILLMASTLRNIPGTLLVDLFFRPIMGDVDITELLEDMLLLR 4nw2 A 1.90 BS01 III B 1 E272 A290 T293 Y295 W322 G324 W325 H329 T331 D408 E424 D425 E3 A21 T24 Y26 W53 G55 W56 H60 T62 D139 E155 D156 O14646 EFETIERFMDCRIGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSECSWEDGALISKKFQACIDEYFS 4nw2 C 1.90 BS01 III D 1 E272 A290 T293 Y295 W322 G324 W325 H329 D408 E424 D425 L428 E3 A21 T24 Y26 W53 G55 W56 H60 D139 E155 D156 L159 O14646 EFETIERFMDCRIGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSECSWEDGALISKKFQACIDEYFS 4nyv A 1.83 BS01 15E A 1 P1110 V1115 L1120 Y1125 N1168 V1174 P30 V35 L40 Y45 N88 V94 Q92793 RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 4nyv B 1.83 BS01 15E B 1 P1110 V1115 L1120 N1168 V1174 P29 V34 L39 N87 V93 Q92793 KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 4nyv C 1.83 BS01 15E C 1 P1110 V1115 L1120 I1122 N1168 R1173 V1174 P28 V33 L38 I40 N86 R91 V92 Q92793 KIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 4nyv D 1.83 BS01 15E D 1 P1110 V1115 L1120 I1122 N1168 R1173 V1174 P28 V33 L38 I40 N86 R91 V92 Q92793 KIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 4nyw A 1.43 BS01 2O3 A 1 P1110 V1115 L1120 I1122 N1168 R1173 V1174 F1177 P29 V34 L39 I41 N87 R92 V93 F96 Q92793 KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG 4nyx A 1.10 BS01 2O4 A 1 L1109 P1110 V1115 L1120 N1168 R1173 V1174 F1177 L28 P29 V34 L39 N87 R92 V93 F96 Q92793 KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG 4o1y A 2.50 BS01 NLA A 1 R6 I9 F22 N23 G30 Y69 F106 R6 I9 F22 N23 G30 Y69 F106 3.1.1.4 P00592 ALWQFRSMIKCAIPGSHPLMDFNNYGCYCGLGGSGTPVDELDRCCETHDNCYRDAKNLDSCKFLVDNPYTESYSYSCSNTEITCNSKNNACEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYC 4o1y A 2.50 BS02 CA A 1 E71 S72 E92 E71 S72 E92 3.1.1.4 P00592 ALWQFRSMIKCAIPGSHPLMDFNNYGCYCGLGGSGTPVDELDRCCETHDNCYRDAKNLDSCKFLVDNPYTESYSYSCSNTEITCNSKNNACEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYC 4o1y A 2.50 BS03 CA A 2 Y28 G30 L31 G32 D49 Y28 G30 L31 G32 D49 3.1.1.4 P00592 ALWQFRSMIKCAIPGSHPLMDFNNYGCYCGLGGSGTPVDELDRCCETHDNCYRDAKNLDSCKFLVDNPYTESYSYSCSNTEITCNSKNNACEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYC 4o4p A 1.83 BS01 HEM A 1 K69 L75 L86 V87 W96 F107 F261 A264 G265 T268 T269 L272 T327 F331 P392 F393 G394 R398 A399 C400 I401 G402 F405 A406 K67 L73 L84 V85 W94 F105 F256 A259 G260 T263 T264 L267 T322 F326 P387 F388 G389 R393 A394 C395 I396 G397 F400 A401 1.14.14.1,1.6.2.4 P14779 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFFGDGLVTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 4o4p A 1.83 BS02 1C6 A 1 V26 Y51 A74 A328 P329 L437 V24 Y49 A72 A323 P324 L432 1.14.14.1,1.6.2.4 P14779 KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFFGDGLVTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 4o4p B 1.83 BS01 HEM B 1 K69 L75 L86 V87 W96 F107 F261 A264 G265 T268 T269 L272 T327 A328 F331 P392 F393 G394 R398 A399 C400 I401 G402 F405 A406 K63 L69 L80 V81 W90 F101 F252 A255 G256 T259 T260 L263 T318 A319 F322 P383 F384 G385 R389 A390 C391 I392 G393 F396 A397 1.14.14.1,1.6.2.4 P14779 EMPQPGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFFGDGLVTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 4o4p B 1.83 BS02 1C6 B 1 V26 Y51 A74 A264 A328 P329 M354 L437 V20 Y45 A68 A255 A319 P320 M345 L428 1.14.14.1,1.6.2.4 P14779 EMPQPGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFFGDGLVTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 4oaa A 3.50 BS01 TDG A 1 F20 M23 F27 P123 E126 R144 G147 C148 W151 E269 N272 H322 L330 Y350 F17 M20 F24 P120 E123 R141 G144 C145 W148 E250 N253 H303 L311 Y331 B1XBJ1 LKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTWIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFWYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSLLR 4oaa B 3.50 BS01 TDG B 1 F20 F27 N119 P123 E126 R144 G147 C148 W151 E269 N272 H322 L330 Y350 K358 F17 F24 N116 P120 E123 R141 G144 C145 W148 E250 N253 H303 L311 Y331 K339 B1XBJ1 LKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTWIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFWYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSLLR 4oad A 1.45 BS01 CLM A 1 F19 P20 E25 Y28 C29 M81 M82 V83 R88 N121 A123 G124 F20 P21 E26 Y29 C30 M82 M83 V84 R89 N122 A124 G125 Q9HV14 HMQLSHRPAETGDLETVAGFPQDRDELFYCYPKAIWPFSVAQLAAAIAERRGSTVAVHDGQVLGFANFYQWQHGDFCALGNMMVAPAARGLGVARYLIGVMENLAREQYKARLMKISCFNANAAGLLLYTQLGYQPRAIAERHDPDGRRVALIQMDKPLE 4oad A 1.45 BS02 CLM A 2 A40 A43 A44 A47 A41 A44 A45 A48 Q9HV14 HMQLSHRPAETGDLETVAGFPQDRDELFYCYPKAIWPFSVAQLAAAIAERRGSTVAVHDGQVLGFANFYQWQHGDFCALGNMMVAPAARGLGVARYLIGVMENLAREQYKARLMKISCFNANAAGLLLYTQLGYQPRAIAERHDPDGRRVALIQMDKPLE 4oae A 1.25 BS01 CLM A 1 F19 P20 E25 Y28 A29 M81 M82 V83 R88 N121 A123 G124 F20 P21 E26 Y29 A30 M82 M83 V84 R89 N122 A124 G125 Q9HV14 HMQLSHRPAETGDLETVAGFPQDRDELFYAYPKAIWPFSVAQLAAAIAERRGSTVAVHDGQVLGFANFYQWQHGDFCALGNMMVAPAARGLGVARYLIGVMENLAREQYKARLMKISAFNANAAGLLLATQLGYQPRAIAERHDPDGRRVALIQMDKPLE 4oae A 1.25 BS02 CLM A 2 A40 A43 A44 A47 A41 A44 A45 A48 Q9HV14 HMQLSHRPAETGDLETVAGFPQDRDELFYAYPKAIWPFSVAQLAAAIAERRGSTVAVHDGQVLGFANFYQWQHGDFCALGNMMVAPAARGLGVARYLIGVMENLAREQYKARLMKISAFNANAAGLLLATQLGYQPRAIAERHDPDGRRVALIQMDKPLE 4oaj A 2.30 BS01 III B 1 L329 G330 F331 S332 I333 A334 N339 H341 T351 H384 V388 L391 L15 G16 F17 S18 I19 A20 N25 H27 T37 H70 V74 L77 Q811D0 AAIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEAVTALKNTSDFVYLKVAKPT 4ocl B 2.40 BS01 ZN B 1 E48 H109 H111 D122 E26 H87 H89 D100 P43588 TKETVYISSIALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVNVVDVFAMPQSGTGVSVEAVDDVFQAKMMDMLKQTGRDQMVVGWYHSHPGFGCWLSSVDVNTQKSFEQLNSRAVAVVVDPIQSVKGKVVIDAFRLIDTGAGLLNKANIQALIHGLNRHYYSLNIDYHKTAKETKMLMNLH 4ocl E 2.40 BS01 ZN E 1 H109 H111 D122 H87 H89 D100 P43588 TKETVYISSIALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVNVVDVFAMPQSGTGVSVEAVDDVFQAKMMDMLKQTGRDQMVVGWYHSHPGFGCWLSSVDVNTQKSFEQLNSRAVAVVVDPIQSVKGKVVIDAFRLIDTGALINNLLNKANIQALIHGLNRHYYSLNIDYHKTAKETKMLMNLH 4ocm B 1.99 BS01 ZN B 1 H109 H111 D122 H85 H87 D98 P43588 TKETVYISSIALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVNVVDVFAMPQSGVSVEAVDDVFQAKMMDMLKQTGRDQMVVGWYHSHPGFGCWLSSVDVNTQKSFEQLNSRAVAVVVDPIQSVKGKVVIDAFRLIDTGLLNKANIQALIHGLNRHYYSLNIDYHKTAKETKMLMNLH 4ocm E 1.99 BS01 ZN E 1 H109 H111 D122 H87 H89 D100 P43588 TKETVYISSIALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVNVVDVFAMPQSGTGVSVEAVDDVFQAKMMDMLKQTGRDQMVVGWYHSHPGFGCWLSSVDVNTQKSFEQLNSRAVAVVVDPIQSVKGKVVIDAFRLIDTGALINNLNKANIQALIHGLNRHYYSLNIDYHKTAKETKMLMNLHK 4odg A 1.73 BS01 THP A 1 R35 L36 D40 D83 K84 Y85 R87 L89 Y113 Y115 R29 L30 D34 D77 K78 Y79 R81 L83 Y107 Y109 3.1.31.1 P00644 LHKEPATLIKAIDGDTIKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEIEFDKGQRTDKYGRGLAYIYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWS 4odg A 1.73 BS02 CA A 1 D21 R35 D40 T41 D15 R29 D34 T35 3.1.31.1 P00644 LHKEPATLIKAIDGDTIKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEIEFDKGQRTDKYGRGLAYIYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWS 4og2 A 1.10 BS01 LEU A 1 L70 T130 L131 S132 S153 N154 T155 F204 D280 G281 F331 L18 T78 L79 S80 S101 N102 T103 F152 D228 G229 F279 Q3MFZ5 NTIPIGIALAQTSNVALLGQEQVAGAKIAEKYFNDKGGVNGTPIKLIFQDTAGDEAGTINAFQTLINKDKVVGIVGPTLSQQAFSANPIAERAKVPVVGPSNTAKGIPEIGDYVARVSAPVSVVAPNSVKAALKQNPNIKKVAVFFAQNDAFSKSETEIFQQTVKDQGLELVTVQKFQTTDTDFQSQATNAINLKPDLVIISGLAADGGNLVRQLRELGYQGAIIGGDGLNTSNVFAVCKALCDGVLIAQAYSPEYTGEINKAFRQAYVDQYKKEPPQFSAQAFAAVQVYVESLKALDTKNKVSKIQLPELRTELNKQLLTGKYNTPLGEISFTPIGEVVQKDFYVAQIKMEKDGSQGKFTFLK 4og2 A 1.10 BS02 MG A 1 P160 G163 V166 I388 P108 G111 V114 I336 Q3MFZ5 NTIPIGIALAQTSNVALLGQEQVAGAKIAEKYFNDKGGVNGTPIKLIFQDTAGDEAGTINAFQTLINKDKVVGIVGPTLSQQAFSANPIAERAKVPVVGPSNTAKGIPEIGDYVARVSAPVSVVAPNSVKAALKQNPNIKKVAVFFAQNDAFSKSETEIFQQTVKDQGLELVTVQKFQTTDTDFQSQATNAINLKPDLVIISGLAADGGNLVRQLRELGYQGAIIGGDGLNTSNVFAVCKALCDGVLIAQAYSPEYTGEINKAFRQAYVDQYKKEPPQFSAQAFAAVQVYVESLKALDTKNKVSKIQLPELRTELNKQLLTGKYNTPLGEISFTPIGEVVQKDFYVAQIKMEKDGSQGKFTFLK 4og2 B 1.10 BS01 LEU B 1 T130 L131 S132 S153 N154 T155 F204 D280 G281 F331 T78 L79 S80 S101 N102 T103 F152 D228 G229 F279 Q3MFZ5 NTIPIGIALAQTSNVALLGQEQVAGAKIAEKYFNDKGGVNGTPIKLIFQDTAGDEAGTINAFQTLINKDKVVGIVGPTLSQQAFSANPIAERAKVPVVGPSNTAKGIPEIGDYVARVSAPVSVVAPNSVKAALKQNPNIKKVAVFFAQNDAFSKSETEIFQQTVKDQGLELVTVQKFQTTDTDFQSQATNAINLKPDLVIISGLAADGGNLVRQLRELGYQGAIIGGDGLNTSNVFAVCKALCDGVLIAQAYSPEYTGEINKAFRQAYVDQYKKEPPQFSAQAFAAVQVYVESLKALDTKNKVSKIQLPELRTELNKQLLTGKYNTPLGEISFTPIGEVVQKDFYVAQIKMEKDGSQGKFTFLK 4og2 B 1.10 BS02 MG B 1 P160 G163 V166 I388 P108 G111 V114 I336 Q3MFZ5 NTIPIGIALAQTSNVALLGQEQVAGAKIAEKYFNDKGGVNGTPIKLIFQDTAGDEAGTINAFQTLINKDKVVGIVGPTLSQQAFSANPIAERAKVPVVGPSNTAKGIPEIGDYVARVSAPVSVVAPNSVKAALKQNPNIKKVAVFFAQNDAFSKSETEIFQQTVKDQGLELVTVQKFQTTDTDFQSQATNAINLKPDLVIISGLAADGGNLVRQLRELGYQGAIIGGDGLNTSNVFAVCKALCDGVLIAQAYSPEYTGEINKAFRQAYVDQYKKEPPQFSAQAFAAVQVYVESLKALDTKNKVSKIQLPELRTELNKQLLTGKYNTPLGEISFTPIGEVVQKDFYVAQIKMEKDGSQGKFTFLK 4ojz A 1.90 BS01 ZN A 1 H415 D433 H464 H386 D404 H435 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNHGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYAQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVRR 4ojz A 1.90 BS02 LGU A 1 K136 K198 H202 H413 H449 Y450 K107 K169 H173 H384 H420 Y421 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNHGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYAQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVRR 4ojz A 1.90 BS03 MAV A 1 Q146 H202 R438 Y450 Q117 H173 R409 Y421 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNHGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYAQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVRR 4ojz A 1.90 BS04 BEM A 1 Q146 N149 Y257 R260 Y261 R438 Q117 N120 Y228 R231 Y232 R409 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNHGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYAQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVRR 4ojz B 1.90 BS01 ZN B 1 H415 D433 H464 H386 D404 H435 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNHGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYAQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVR 4ojz B 1.90 BS02 LGU B 1 K136 H200 H202 H413 H449 Y450 K107 H171 H173 H384 H420 Y421 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNHGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYAQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVR 4ojz B 1.90 BS03 MAV B 1 Q146 N201 H202 H413 R438 Y450 Q117 N172 H173 H384 R409 Y421 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNHGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYAQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVR 4ojz B 1.90 BS04 BEM B 1 Q146 L148 N149 Y257 R260 Y261 R438 Q117 L119 N120 Y228 R231 Y232 R409 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNHGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYAQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVR 4ok2 A 2.45 BS01 ZN A 1 H415 D433 H464 H386 D404 H435 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNHGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYAQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVRR 4ok2 B 2.45 BS01 ZN B 1 H415 D433 H464 H385 D403 H434 Q21FJ0 PNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNHGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYAQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVRR 4ok4 A 1.70 BS01 ZN A 1 H415 D433 H464 H386 D404 H435 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNLGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYYQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVV 4ok4 B 1.70 BS01 ZN B 1 H415 D433 H464 H386 D404 H435 Q21FJ0 HPNLIVTEQDVANIAASWESYDAYAEQLNADKTNLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAYAKMYPSLGEHPNRKEQSPGRLFWQSLNEAVWLVYSIQGYDAIIDGLAAEEKQEIESGVFLPMAKFLSVESPETFNKIHNLGTWAVAAVGMTGYVLGNDELVEISLMGLDKTGKAGFMKQLDKLFSPDGYYTEGPYYQRYALMPFIWFAKAIETNEPERKIFEYRNNILLKAVYTTIDLSYAGYFFPINDALKDKGIDTVELVHALAIVYSITGDNTLLDIAQEQGRISLTGDGLKVAKAVGEGLTQPYNYRSILLGDGADGDQGALSIHRLGEGHNHMALVAKNTSQGMGHGHFDKLNWLLYDNGNEIVTDYGAARYLNVEAKYGGHYLAENNTWAKQTIAHNTLVVNEQSHFYGDVTTADLHHPEVLSFYSGEDYQLSSAKEANAYDGVEFVRSMLLVNVPSLEHPIVVDVLNVSADKASTFDLPLYFNGQIIDFSFKVKDNKNVMKMLGKRNGYQHLWLRNTAPVGDASERATWILDDRFYSYAFVTSTPSKKQNVLIAELGANDPNYNLRQQQVLIRRVEKAKQASFVSVLEPHGKYDGSLETTSGAYSNVKSVKHVSENGKDVVVVDLKDGSNVVVALSYNANSEQVHKVNAGEEAIEWKGFSSVVVR