2lxh C BS01 ZN C 1 C341 C344 H361 C364 C15 C18 H35 C38 6.3.2.- Q9UKV5 23942235 AVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNI 2lxh C BS02 ZN C 2 C356 H358 C375 C378 C30 H32 C49 C52 6.3.2.- Q9UKV5 23942235 AVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNI 2lxp A BS01 III B 1 Y13 L16 T17 P20 G23 I24 V25 A26 G27 P28 N30 E31 E38 L40 M42 E45 E50 F51 V53 V159 Q160 S162 L163 G164 L165 Y12 L15 T16 P19 G22 I23 V24 A25 G26 P27 N29 E30 E37 L39 M41 E44 E49 F50 V52 V150 Q151 S153 L154 G155 L156 6.3.2.19 P60604 23942235 AGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPAILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL 2lxp C BS01 ZN C 1 C341 C344 H361 C364 C15 C18 H35 C38 6.3.2.- Q9UKV5 23942235 AVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNI 2lxp C BS02 ZN C 2 C356 H358 C375 C378 C30 H32 C49 C52 6.3.2.- Q9UKV5 23942235 AVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNI 2m3o W BS01 III P 1 R430 F438 I440 H442 K445 T447 W449 R15 F23 I25 H27 K30 T32 W34 P46934 23665454 GSMEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPA 2mc1 A BS01 III B 1 E677 R678 A679 R696 Q697 R698 E704 A706 K716 H717 I718 K719 E731 K732 K755 S756 E17 R18 A19 R36 Q37 R38 E44 A46 K56 H57 I58 K59 E71 K72 K95 S96 P15498 GHMQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKE 2ymz B 1.75 BS01 LAT B 1 H45 N47 R49 V56 N58 W65 E68 R70 H44 N46 R48 V55 N57 W64 E67 R69 E1C0Z4 ARMFEMFNLDWKSGGTMKIKGHISEDAESFAINLGCKSSDLALHFNPRFNESVIVCNSLCSDNWQQEQRDKHFNFYKGSTVKIIVEFLGDKFLVKLPDGHEVEFPNRHGYDKISYLNILGGFKVTSFKVE 2ymz D 1.75 BS01 LAT D 1 H45 N47 R49 N58 W65 E68 R70 H44 N46 R48 N57 W64 E67 R69 E1C0Z4 ARMFEMFNLDWKSGGTMKIKGHISEDAESFAINLGCKSSDLALHFNPRFNESVIVCNSLCSDNWQQEQRDKHFNFYKGSTVKIIVEFLGDKFLVKLPDGHEVEFPNRHGYDKISYLNILGGFKVTSFKVE 2ypf A 2.55 BS01 NUC B 1 R236 R266 G267 V269 T270 D301 G302 Q305 G336 K338 Q339 I369 Q373 G404 Q407 I437 G438 Q441 I471 G472 Q475 I505 K508 Q509 D539 G540 Q543 D573 G574 Q577 G607 G608 K610 Q611 I641 G642 K644 Q645 I675 G676 K678 Q679 D709 G710 K712 Q713 D743 G744 K746 Q747 D777 G778 K780 Q781 G811 K814 Q815 D845 K848 Q849 R50 R80 G81 V83 T84 D115 G116 Q119 G150 K152 Q153 I183 Q187 G218 Q221 I251 G252 Q255 I285 G286 Q289 I319 K322 Q323 D353 G354 Q357 D387 G388 Q391 G421 G422 K424 Q425 I455 G456 K458 Q459 I489 G490 K492 Q493 D523 G524 K526 Q527 D557 G558 K560 Q561 D591 G592 K594 Q595 G625 K628 Q629 D659 K662 Q663 AFTHAHIVALSQHPAALATVAVKYQDMIAALPEATHEAIVAVAKQWSGARALEALLTVAGELRGPPLQLDTGQLLKIAKRGGVTAVEAVHAWRNALTGAPLNLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPQQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPQQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPQQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPQQVVAIASNGGGKQALETVQRLLPVLCQAAGLTPEQVVAIASHDGGKQALETVQRLLPVL 2ypf A 2.55 BS02 NUC C 1 H742 H776 H556 H590 AFTHAHIVALSQHPAALATVAVKYQDMIAALPEATHEAIVAVAKQWSGARALEALLTVAGELRGPPLQLDTGQLLKIAKRGGVTAVEAVHAWRNALTGAPLNLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPQQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPQQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPQQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASNIGGKQALETVQALLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPQQVVAIASNGGGKQALETVQRLLPVLCQAAGLTPEQVVAIASHDGGKQALETVQRLLPVL 3j47 V BS01 III Q 1 Y251 I255 E258 K259 T262 E265 L266 R269 Y22 I26 E29 K30 T33 E36 L37 R40 P43588 23911091 YEEKEESNLAATKSMVKIAEQYSKRIEEEKELTEEELKTRPKKHLSETADETLENNIVSVLTA 3j47 V BS02 III T 1 L288 I292 V295 L53 I57 V60 P43588 23911091 YEEKEESNLAATKSMVKIAEQYSKRIEEEKELTEEELKTRPKKHLSETADETLENNIVSVLTA 3j47 U BS01 III O 1 L190 Q193 L197 L200 L204 V207 L211 L226 L229 Q230 F233 L3 Q6 L10 L13 L17 V20 L24 L32 L35 Q36 F39 Q08723 23911091 IRLTNQLKSLKGLQSKLKDVVEYLDKVIHTILGKLQDVFNLNNLQKALTVKTNDELMVIYISNLVRSIIAFDDLIENKIQNKKIQEQRVKD 3j47 U BS02 III Q 1 V275 V282 I285 I286 D289 I292 E293 I296 Q297 K300 V58 V65 I68 I69 D72 I75 E76 I79 Q80 K83 Q08723 23911091 IRLTNQLKSLKGLQSKLKDVVEYLDKVIHTILGKLQDVFNLNNLQKALTVKTNDELMVIYISNLVRSIIAFDDLIENKIQNKKIQEQRVKD 3j47 U BS03 III R 1 M274 I278 I285 F288 D289 I292 I296 M57 I61 I68 F71 D72 I75 I79 Q08723 23911091 IRLTNQLKSLKGLQSKLKDVVEYLDKVIHTILGKLQDVFNLNNLQKALTVKTNDELMVIYISNLVRSIIAFDDLIENKIQNKKIQEQRVKD 3j47 U BS04 III S 1 N270 L273 M274 I276 Y277 I278 N280 L281 S284 F288 D290 L291 I292 N294 K295 N53 L56 M57 I59 Y60 I61 N63 L64 S67 F71 D73 L74 I75 N77 K78 Q08723 23911091 IRLTNQLKSLKGLQSKLKDVVEYLDKVIHTILGKLQDVFNLNNLQKALTVKTNDELMVIYISNLVRSIIAFDDLIENKIQNKKIQEQRVKD 3j47 U BS05 III T 1 N280 L281 S284 N63 L64 S67 Q08723 23911091 IRLTNQLKSLKGLQSKLKDVVEYLDKVIHTILGKLQDVFNLNNLQKALTVKTNDELMVIYISNLVRSIIAFDDLIENKIQNKKIQEQRVKD 3vvg A 1.90 BS01 ZGB A 1 N270 A271 W272 W273 V303 Q306 N237 A238 W239 W240 V270 Q273 O58925 QTPTGIYYEVRGDTIYMINVTSGEETPIHLFGVNWFGFETPNHVVHGLWKRNWEDMLLQIKSLGFNAIRLPFCTESVKPGTQPIGIDYSKNPDLRGLDSLQIMEKIIKKAGDLGIFVLLDYHRIGCTHIEPLWYTEDFSEEDFINTWIEVAKRFGKYWNVIGADLKNEPHSVTSPPAAYTDGTGATWGMGNPATDWNLAAERIGKAILKVAPHWLIFVEGTQFTNPKTDSSYKWGYNAWWGGNLMAVKDYPVNLPKNKLVYSPHVYGPDVYNQPYFGPAKGFPDNLPDIWYHHFGYVKLELGYSVVIGEFGGKYGHGGDPRDVIWQNKLVDWMIENKFCDFFYWSWNPDSGDTGGILQDDWTTIWEDKYNNLKRLMD 3vvg A 1.90 BS02 ZGB A 2 T37 W191 T4 W158 O58925 QTPTGIYYEVRGDTIYMINVTSGEETPIHLFGVNWFGFETPNHVVHGLWKRNWEDMLLQIKSLGFNAIRLPFCTESVKPGTQPIGIDYSKNPDLRGLDSLQIMEKIIKKAGDLGIFVLLDYHRIGCTHIEPLWYTEDFSEEDFINTWIEVAKRFGKYWNVIGADLKNEPHSVTSPPAAYTDGTGATWGMGNPATDWNLAAERIGKAILKVAPHWLIFVEGTQFTNPKTDSSYKWGYNAWWGGNLMAVKDYPVNLPKNKLVYSPHVYGPDVYNQPYFGPAKGFPDNLPDIWYHHFGYVKLELGYSVVIGEFGGKYGHGGDPRDVIWQNKLVDWMIENKFCDFFYWSWNPDSGDTGGILQDDWTTIWEDKYNNLKRLMD 3vvg C 1.90 BS01 ZGB C 1 I39 M50 N52 F149 W191 I6 M17 N19 F116 W158 O58925 QTPTGIYYEVRGDTIYMINVTSGEETPIHLFGVNWFGFETPNHVVHGLWKRNWEDMLLQIKSLGFNAIRLPFCTESVKPGTQPIGIDYSKNPDLRGLDSLQIMEKIIKKAGDLGIFVLLDYHRIGCTHIEPLWYTEDFSEEDFINTWIEVAKRFGKYWNVIGADLKNEPHSVTSPPAAYTDGTGATWGMGNPATDWNLAAERIGKAILKVAPHWLIFVEGTQFTNPKTDSSYKWGYNAWWGGNLMAVKDYPVNLPKNKLVYSPHVYGPDVYNQPYFGPAKGFPDNLPDIWYHHFGYVKLELGYSVVIGEFGGKYGHGGDPRDVIWQNKLVDWMIENKFCDFFYWSWNPDSGDTGGILQDDWTTIWEDKYNNLKRLMD 3vvh A 2.00 BS01 MG A 1 N195 D208 N135 D148 2.7.12.2 Q02750 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMATRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 3vvh A 2.00 BS02 ATP A 1 L74 G75 A76 G77 N78 V82 A95 K97 M143 E144 M146 S150 Q153 K192 S194 N195 L197 D208 L14 G15 A16 G17 N18 V22 A35 K37 M83 E84 M86 S90 Q93 K132 S134 N135 L137 D148 2.7.12.2 Q02750 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMATRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 3vvh A 2.00 BS03 4BM A 1 G77 G79 G80 K97 L115 L118 V127 I141 M143 D208 F209 G210 V211 S212 L215 M219 G17 G19 G20 K37 L55 L58 V67 I81 M83 D148 F149 G150 V151 S152 L155 M159 2.7.12.2 Q02750 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMATRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 3vvh B 2.00 BS01 MG B 1 N195 D208 N135 D148 2.7.12.2 Q02750 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 3vvh B 2.00 BS02 ATP B 1 L74 G75 G77 N78 V82 A95 K97 M143 E144 M146 S150 Q153 K192 S194 N195 L197 D208 L14 G15 G17 N18 V22 A35 K37 M83 E84 M86 S90 Q93 K132 S134 N135 L137 D148 2.7.12.2 Q02750 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 3vvh B 2.00 BS03 4BM B 1 G79 G80 K97 L115 L118 V127 I141 M143 D208 F209 G210 V211 S212 L215 M219 G19 G20 K37 L55 L58 V67 I81 M83 D148 F149 G150 V151 S152 L155 M159 2.7.12.2 Q02750 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 3vvh C 2.00 BS01 MG C 1 N195 D208 N135 D148 2.7.12.2 Q02750 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 3vvh C 2.00 BS02 ATP C 1 L74 G75 G77 N78 V82 A95 K97 M143 E144 M146 S150 Q153 K192 S194 N195 L197 D208 L14 G15 G17 N18 V22 A35 K37 M83 E84 M86 S90 Q93 K132 S134 N135 L137 D148 2.7.12.2 Q02750 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 3vvh C 2.00 BS03 4BM C 1 G77 G79 G80 K97 L115 L118 V127 I141 M143 C207 D208 F209 V211 S212 L215 M219 G17 G19 G20 K37 L55 L58 V67 I81 M83 C147 D148 F149 V151 S152 L155 M159 2.7.12.2 Q02750 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 3vwd A 1.25 BS01 ACO A 1 Q58 I121 D123 F124 Y125 I126 Q131 R132 H133 G134 G136 R137 D157 R158 P159 S160 K162 L163 K165 F166 K169 H170 Q59 I120 D122 F123 Y124 I125 Q130 R131 H132 G133 G135 R136 D156 R157 P158 S159 K161 L162 K164 F165 K168 H169 2.3.1.108 Q5SQI0 SMEFPFDVDALFPERITVLDQHLRPPARRPGTTTPARVDLQQQIMTIIDELGKASAKAQNLSAPITSASRMQSNRHVVYILKDSSARPAGAIIGFIKVGYKKLFVLDDREAHNEVEPLCILDFYIHESVQRHGHGRELFQYMLQKERVEPHQLAIDRPSQKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHEFG 3vwe A 1.96 BS01 COA A 1 Q58 F124 Y125 I126 Q131 R132 H133 G134 G136 R137 S160 K162 L163 K165 F166 K169 H170 Q54 F119 Y120 I121 Q126 R127 H128 G129 G131 R132 S155 K157 L158 K160 F161 K164 H165 2.3.1.108 Q5SQI0 SMEFPFDVDALFPERITVLDQHLRPPARTPARVDLQQQIMTIIDELGKASAKAQNLSAPITSASRMQSNRHVVYILKDSSARAGKGAIIGFIKVGYKKLFVLDDREAHNEVEPLCILDFYIHESVQRHGHGRELFQYMLQKERVEPHQLAIDRPSQKLLKFLNKHYNLETTVPQVNNFVIFEGFFA 3vzs A 2.14 BS01 NAP A 1 G10 C34 G35 R40 G60 N61 V62 A89 G90 I91 T92 P183 G184 I186 T188 M190 V191 G8 C32 G33 R38 G58 N59 V60 A87 G88 I89 T90 P181 G182 I184 T186 M188 V189 1.1.1.36 P14697 23913421 QRIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNTVSPGYIATDMVKAIRQDVLDKIVATIPVKRLGLPEEIASICAWLSSEESGFSTGADFSLNGGLHMG 3vzs A 2.14 BS02 CAA A 1 T92 D94 S140 N142 Q147 F148 G149 Q150 Y153 G184 Y185 I194 R195 V198 K201 I202 T90 D92 S138 N140 Q145 F146 G147 Q148 Y151 G182 Y183 I192 R193 V196 K199 I200 1.1.1.36 P14697 23913421 QRIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNTVSPGYIATDMVKAIRQDVLDKIVATIPVKRLGLPEEIASICAWLSSEESGFSTGADFSLNGGLHMG 3vzs B 2.14 BS01 NAP B 1 G10 I15 C34 G35 R40 G60 N61 V62 A89 G90 I91 T92 T111 S139 P183 G184 I186 T188 M190 V191 G13 I18 C37 G38 R43 G63 N64 V65 A92 G93 I94 T95 T114 S142 P186 G187 I189 T191 M193 V194 1.1.1.36 P14697 23913421 HHGSTQRIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNTVSPGYIATDMVKAIRQDVLDKIVATIPVKRLGLPEEIASICAWLSSEESGFSTGADFSLNGGLHMG 3vzs B 2.14 BS02 CAA B 1 T92 D94 Q147 F148 G149 Q150 Y153 G184 Y185 M190 I194 R195 V198 T95 D97 Q150 F151 G152 Q153 Y156 G187 Y188 M193 I197 R198 V201 1.1.1.36 P14697 23913421 HHGSTQRIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNTVSPGYIATDMVKAIRQDVLDKIVATIPVKRLGLPEEIASICAWLSSEESGFSTGADFSLNGGLHMG 3vzs C 2.14 BS01 NAP C 1 G10 I15 G35 R40 G60 N61 V62 A89 G90 I91 T92 T111 S139 P183 G184 I186 T188 M190 V191 G8 I13 G33 R38 G58 N59 V60 A87 G88 I89 T90 T109 S137 P181 G182 I184 T186 M188 V189 1.1.1.36 P14697 23913421 QRIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNTVSPGYIATDMVKAIRQDVLDKIVATIPVKRLGLPEEIASICAWLSSEESGFSTGADFSLNGGLHMG 3vzs C 2.14 BS02 CAA C 1 T92 D94 S140 N142 Q147 F148 G149 Q150 Y153 G184 Y185 M190 V191 R195 T90 D92 S138 N140 Q145 F146 G147 Q148 Y151 G182 Y183 M188 V189 R193 1.1.1.36 P14697 23913421 QRIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNTVSPGYIATDMVKAIRQDVLDKIVATIPVKRLGLPEEIASICAWLSSEESGFSTGADFSLNGGLHMG 3vzs D 2.14 BS01 NAP D 1 G10 I15 C34 G35 R40 G60 N61 V62 A89 G90 I91 T92 P183 G184 I186 T188 M190 V191 G13 I18 C37 G38 R43 G63 N64 V65 A92 G93 I94 T95 P186 G187 I189 T191 M193 V194 1.1.1.36 P14697 23913421 HHGSTQRIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNTVSPGYIATDMVKAIRQDVLDKIVATIPVKRLGLPEEIASICAWLSSEESGFSTGADFSLNGGLHMG 3vzs D 2.14 BS02 CAA D 1 T92 D94 S140 N142 Q147 F148 G149 Q150 Y153 G184 Y185 M190 V191 I194 R195 V198 T95 D97 S143 N145 Q150 F151 G152 Q153 Y156 G187 Y188 M193 V194 I197 R198 V201 1.1.1.36 P14697 23913421 HHGSTQRIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVIDGMADRGWGRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNTVSPGYIATDMVKAIRQDVLDKIVATIPVKRLGLPEEIASICAWLSSEESGFSTGADFSLNGGLHMG 3w96 A 3.00 BS01 NUC I 1 H39 R42 P43 T45 R63 R72 R83 F84 Q85 S86 R116 V117 T118 M120 H1 R4 P5 T7 R25 R34 R45 F46 Q47 S48 R78 V79 T80 M82 P68431 HRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 3w96 A 3.00 BS02 NUC J 1 H39 R40 Y41 P43 G44 V46 A47 R49 K56 R63 K64 L65 R69 D81 R83 H1 R2 Y3 P5 G6 V8 A9 R11 K18 R25 K26 L27 R31 D43 R45 P68431 HRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 3w96 B 3.00 BS01 NUC I 1 T30 P32 R36 R45 T5 P7 R11 R20 P62805 IQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 3w96 B 3.00 BS02 NUC J 1 R45 I46 S47 G48 R78 K79 T80 R20 I21 S22 G23 R53 K54 T55 P62805 IQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 3w96 C 3.00 BS01 NUC I 1 A14 K15 T16 R17 G28 R32 R42 K74 A3 K4 T5 R6 G17 R21 R31 K63 P04908 AKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w96 C 3.00 BS02 NUC J 1 R29 R42 V43 G44 A45 K75 T76 R77 R18 R31 V32 G33 A34 K64 T65 R66 P04908 AKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w96 D 3.00 BS01 NUC I 1 K30 S32 R33 Y42 G53 I54 S55 S56 R86 S87 T88 K1 S3 R4 Y13 G24 I25 S26 S27 R57 S58 T59 P06899 KRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 3w96 D 3.00 BS02 NUC J 1 R31 R33 K34 E35 S36 I39 Y40 R2 R4 K5 E6 S7 I10 Y11 P06899 KRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 3w96 E 3.00 BS01 NUC I 1 H39 R40 Y41 P43 G44 V46 A47 R49 K56 R63 K64 L65 R69 R83 H2 R3 Y4 P6 G7 V9 A10 R12 K19 R26 K27 L28 R32 R46 P68431 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 3w96 E 3.00 BS02 NUC J 1 R40 Y41 R42 P43 T45 R63 R72 R83 F84 Q85 S86 R116 V117 T118 R3 Y4 R5 P6 T8 R26 R35 R46 F47 Q48 S49 R79 V80 T81 P68431 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 3w96 F 3.00 BS01 NUC I 1 R45 I46 S47 G48 R78 K79 T80 R26 I27 S28 G29 R59 K60 T61 P62805 KVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG 3w96 F 3.00 BS02 NUC J 1 T30 P32 R36 R45 T11 P13 R17 R26 P62805 KVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFG 3w96 G 3.00 BS01 NUC I 1 R29 R42 V43 G44 A45 K75 T76 R77 R14 R27 V28 G29 A30 K60 T61 R62 P04908 TRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w96 G 3.00 BS02 NUC J 1 R17 R29 R32 R42 R2 R14 R17 R27 P04908 TRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w96 H 3.00 BS01 NUC I 1 R33 K34 E35 S36 I39 Y40 R1 K2 E3 S4 I7 Y8 P06899 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTS 3w96 H 3.00 BS02 NUC J 1 R33 Y42 I54 S55 S56 R86 S87 T88 R1 Y10 I22 S23 S24 R54 S55 T56 P06899 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTS 3w97 A 3.20 BS01 NUC I 1 H39 R42 P43 T45 R63 R72 R83 F84 Q85 R116 V117 T118 M120 H2 R5 P6 T8 R26 R35 R46 F47 Q48 R79 V80 T81 M83 P68431 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 3w97 A 3.20 BS02 NUC J 1 H39 R40 Y41 P43 G44 T45 V46 A47 R49 R53 K56 R63 K64 L65 R69 R83 H2 R3 Y4 P6 G7 T8 V9 A10 R12 R16 K19 R26 K27 L28 R32 R46 P68431 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 3w97 B 3.20 BS01 NUC I 1 P32 R45 P8 R21 P62805 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 3w97 B 3.20 BS02 NUC J 1 R45 I46 S47 G48 R78 K79 T80 R21 I22 S23 G24 R54 K55 T56 P62805 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 3w97 C 3.20 BS01 NUC I 1 A14 K15 T16 R17 G28 R32 R42 A2 K3 T4 R5 G16 R20 R30 P04908 KAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w97 C 3.20 BS02 NUC J 1 R29 R42 V43 G44 A45 K75 T76 R77 R17 R30 V31 G32 A33 K63 T64 R65 P04908 KAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w97 D 3.20 BS01 NUC I 1 S32 G53 S55 S56 R86 S87 T88 S1 G22 S24 S25 R55 S56 T57 P06899 SRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 3w97 D 3.20 BS02 NUC J 1 S32 R33 K34 E35 S36 I39 Y40 S1 R2 K3 E4 S5 I8 Y9 P06899 SRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 3w97 E 3.20 BS01 NUC I 1 K37 H39 R40 Y41 P43 G44 V46 A47 R49 K56 R63 K64 L65 R69 R83 K1 H3 R4 Y5 P7 G8 V10 A11 R13 K20 R27 K28 L29 R33 R47 P68431 KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 3w97 E 3.20 BS02 NUC J 1 K37 R40 Y41 R42 P43 T45 R63 R72 R83 F84 Q85 S86 R116 V117 T118 K1 R4 Y5 R6 P7 T9 R27 R36 R47 F48 Q49 S50 R80 V81 T82 P68431 KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 3w97 F 3.20 BS01 NUC I 1 R45 I46 S47 G48 R78 K79 T80 R27 I28 S29 G30 R60 K61 T62 P62805 RKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 3w97 F 3.20 BS02 NUC J 1 R19 T30 P32 R36 R45 R1 T12 P14 R18 R27 P62805 RKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 3w97 G 3.20 BS01 NUC I 1 R29 R42 V43 G44 A45 K75 T76 R77 R14 R27 V28 G29 A30 K60 T61 R62 P04908 TRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w97 G 3.20 BS02 NUC J 1 R17 R20 R32 R42 R77 R2 R5 R17 R27 R62 P04908 TRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w97 H 3.20 BS01 NUC I 1 R33 K34 E35 S36 I39 Y40 R1 K2 E3 S4 I7 Y8 P06899 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 3w97 H 3.20 BS02 NUC J 1 I54 S56 R86 S87 T88 I22 S24 R54 S55 T56 P06899 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 3w98 A 3.42 BS01 NUC I 1 R42 P43 T45 R63 R72 R83 F84 Q85 R116 V117 T118 M120 R5 P6 T8 R26 R35 R46 F47 Q48 R79 V80 T81 M83 P68431 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 3w98 A 3.42 BS02 NUC J 1 H39 R40 Y41 P43 G44 T45 V46 A47 R49 R53 R63 K64 L65 R69 R83 H2 R3 Y4 P6 G7 T8 V9 A10 R12 R16 R26 K27 L28 R32 R46 P68431 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 3w98 B 3.42 BS01 NUC I 1 P32 R36 R45 P8 R12 R21 P62805 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGF 3w98 B 3.42 BS02 NUC J 1 R45 I46 S47 G48 R78 K79 T80 R21 I22 S23 G24 R54 K55 T56 P62805 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGF 3w98 C 3.42 BS01 NUC I 1 T16 R17 G28 R32 R42 T4 R5 G16 R20 R30 P04908 KAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w98 C 3.42 BS02 NUC J 1 A14 R29 R42 V43 G44 A45 K75 T76 R77 A2 R17 R30 V31 G32 A33 K63 T64 R65 P04908 KAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w98 D 3.42 BS01 NUC I 1 K30 S32 R33 I54 S55 S56 R86 S87 T88 K1 S3 R4 I25 S26 S27 R57 S58 T59 P06899 KRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 3w98 D 3.42 BS02 NUC J 1 K30 R31 R33 K34 E35 S36 I39 Y40 K1 R2 R4 K5 E6 S7 I10 Y11 P06899 KRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 3w98 E 3.42 BS01 NUC I 1 K37 H39 R40 Y41 P43 G44 T45 V46 A47 R49 R63 K64 L65 R69 R83 K1 H3 R4 Y5 P7 G8 T9 V10 A11 R13 R27 K28 L29 R33 R47 P68431 KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 3w98 E 3.42 BS02 NUC J 1 K37 R40 Y41 R42 P43 T45 R63 R72 R83 F84 Q85 S86 R116 V117 T118 K1 R4 Y5 R6 P7 T9 R27 R36 R47 F48 Q49 S50 R80 V81 T82 P68431 KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 3w98 F 3.42 BS01 NUC I 1 R45 I46 S47 G48 R78 K79 T80 R27 I28 S29 G30 R60 K61 T62 P62805 RKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 3w98 F 3.42 BS02 NUC J 1 R19 T30 P32 R36 R45 R1 T12 P14 R18 R27 P62805 RKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 3w98 G 3.42 BS01 NUC I 1 R29 R42 V43 G44 A45 K75 T76 R77 R15 R28 V29 G30 A31 K61 T62 R63 P04908 KTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w98 G 3.42 BS02 NUC J 1 K15 R17 R20 G28 R29 R32 R42 K1 R3 R6 G14 R15 R18 R28 P04908 KTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w98 H 3.42 BS01 NUC I 1 R33 K34 E35 S36 I39 Y40 R1 K2 E3 S4 I7 Y8 P06899 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTS 3w98 H 3.42 BS02 NUC J 1 Y42 S56 R86 S87 T88 Y10 S24 R54 S55 T56 P06899 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTS 3w99 A 3.00 BS01 NUC I 1 R40 R42 P43 T45 R63 R72 R83 F84 Q85 S86 R116 V117 T118 M120 R3 R5 P6 T8 R26 R35 R46 F47 Q48 S49 R79 V80 T81 M83 P68431 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 3w99 A 3.00 BS02 NUC J 1 H39 R40 Y41 R42 P43 G44 T45 V46 A47 R49 K56 R63 K64 L65 R69 D81 R83 H2 R3 Y4 R5 P6 G7 T8 V9 A10 R12 K19 R26 K27 L28 R32 D44 R46 P68431 PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER 3w99 B 3.00 BS01 NUC I 1 T30 P32 R45 T6 P8 R21 P62805 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 3w99 B 3.00 BS02 NUC J 1 R45 I46 S47 G48 R78 K79 T80 R21 I22 S23 G24 R54 K55 T56 P62805 NIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 3w99 C 3.00 BS01 NUC I 1 T16 R17 R20 G28 R29 R32 K74 T3 R4 R7 G15 R16 R19 K61 P04908 AKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w99 C 3.00 BS02 NUC J 1 R29 R42 V43 G44 A45 K75 T76 R77 R16 R29 V30 G31 A32 K62 T63 R64 P04908 AKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w99 D 3.00 BS01 NUC I 1 K30 S32 R33 G53 I54 S55 S56 R86 S87 T88 K1 S3 R4 G24 I25 S26 S27 R57 S58 T59 P06899 KRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 3w99 D 3.00 BS02 NUC J 1 R31 S32 R33 K34 E35 S36 I39 Y40 R2 S3 R4 K5 E6 S7 I10 Y11 P06899 KRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 3w99 E 3.00 BS01 NUC I 1 K37 H39 R40 Y41 P43 G44 V46 A47 R49 K56 R63 K64 L65 R69 R83 K1 H3 R4 Y5 P7 G8 V10 A11 R13 K20 R27 K28 L29 R33 R47 P68431 KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 3w99 E 3.00 BS02 NUC J 1 K37 H39 R40 Y41 R42 P43 T45 R63 R72 R83 F84 Q85 S86 R116 V117 T118 M120 K1 H3 R4 Y5 R6 P7 T9 R27 R36 R47 F48 Q49 S50 R80 V81 T82 M84 P68431 KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA 3w99 F 3.00 BS01 NUC I 1 R45 I46 S47 G48 R78 K79 T80 R27 I28 S29 G30 R60 K61 T62 P62805 RKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 3w99 F 3.00 BS02 NUC J 1 R19 T30 P32 R36 R45 R1 T12 P14 R18 R27 P62805 RKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 3w99 G 3.00 BS01 NUC I 1 R29 R42 V43 G44 A45 K75 T76 R77 R13 R26 V27 G28 A29 K59 T60 R61 P04908 RSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w99 G 3.00 BS02 NUC J 1 R17 R20 R29 R32 R42 R77 R1 R4 R13 R16 R26 R61 P04908 RSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPK 3w99 H 3.00 BS01 NUC I 1 R33 K34 E35 S36 I39 Y40 R1 K2 E3 S4 I7 Y8 P06899 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 3w99 H 3.00 BS02 NUC J 1 G53 I54 S55 S56 R86 S87 T88 G21 I22 S23 S24 R54 S55 T56 P06899 RKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA 3zho A 1.20 BS01 FMN A 1 S9 M10 Y11 G12 H13 I14 P76 T77 R78 F79 S112 T113 G114 T115 G116 G117 S9 M10 Y11 G12 H13 I14 P76 T77 R78 F79 S112 T113 G114 T115 G116 G117 1.6.5.2 P0A8G6 AKVLVLYYSMYGHIETMARAVAEGASKVDGAEVVVKRVPETMPPQLFEKAGGKTQTAPVATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLASVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYAAQELFDVSQVTPYGATTIAGGDGSRQPSQEELSIARYQGEYVAGLAVKLNG 3zho A 1.20 BS02 FMN B 1 D91 H132 D91 H132 1.6.5.2 P0A8G6 AKVLVLYYSMYGHIETMARAVAEGASKVDGAEVVVKRVPETMPPQLFEKAGGKTQTAPVATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLASVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYAAQELFDVSQVTPYGATTIAGGDGSRQPSQEELSIARYQGEYVAGLAVKLNG 3zho B 1.20 BS01 FMN A 1 D91 H132 D91 H132 1.6.5.2 P0A8G6 AKVLVLYYSMYGHIETMARAVAEGASKVDGAEVVVKRVPETMPPQLFEKAGGKTQTAPVATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLASVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYGTPYGATTIAGQPSQEELSIARYQGEYVAGLAVKLNG 3zho B 1.20 BS02 FMN B 1 S9 M10 Y11 G12 H13 I14 P76 T77 R78 F79 S112 T113 G114 T115 G116 G117 S9 M10 Y11 G12 H13 I14 P76 T77 R78 F79 S112 T113 G114 T115 G116 G117 1.6.5.2 P0A8G6 AKVLVLYYSMYGHIETMARAVAEGASKVDGAEVVVKRVPETMPPQLFEKAGGKTQTAPVATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLASVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYGTPYGATTIAGQPSQEELSIARYQGEYVAGLAVKLNG 4b7d A 1.89 BS01 HEM A 1 K72 M92 L93 H100 R104 F111 L240 A243 G244 T247 T248 L251 P289 A293 T294 R296 A346 F347 G348 I351 H352 C354 I355 G356 A360 K59 M79 L80 H87 R91 F98 L227 A230 G231 T234 T235 L238 P276 A280 T281 R283 A333 F334 G335 I338 H339 C341 I342 G343 A347 O87605 VLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGDEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4b7d A 1.89 BS02 QLE A 1 E85 N89 L93 E94 V179 H238 I239 V242 A243 T247 T294 M394 E72 N76 L80 E81 V166 H225 I226 V229 A230 T234 T281 M381 O87605 VLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGDEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4b7d B 1.89 BS01 HEM B 1 K72 M92 L93 H100 R104 F111 I157 I239 L240 A243 G244 T247 T248 L251 P289 A293 T294 R296 A346 F347 G348 H352 C354 I355 G356 A360 K59 M79 L80 H87 R91 F98 I144 I226 L227 A230 G231 T234 T235 L238 P276 A280 T281 R283 A333 F334 G335 H339 C341 I342 G343 A347 O87605 VLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGDEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4b7d B 1.89 BS02 QLE B 1 W74 L81 E85 L93 E94 H238 V242 A243 T247 M394 I395 W61 L68 E72 L80 E81 H225 V229 A230 T234 M381 I382 O87605 VLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGDEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4b7f A 1.76 BS01 NDP A 1 P146 H189 Y193 R198 H230 T297 W298 S299 Q300 Q456 L460 V464 L465 E469 P145 H188 Y192 R197 H229 T296 W297 S298 Q299 Q455 L459 V463 L464 E468 1.11.1.6 Q6M8A6 SEKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7f A 1.76 BS02 NO A 1 P70 H71 F156 Y353 P69 H70 F155 Y352 1.11.1.6 Q6M8A6 SEKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7f A 1.76 BS03 HEM A 1 R68 P70 H71 R107 G126 A128 V141 G142 N143 G153 F156 G211 S212 H213 L294 L329 M345 A348 R349 A352 Y353 Q356 Q357 R360 R67 P69 H70 R106 G125 A127 V140 G141 N142 G152 F155 G210 S211 H212 L293 L328 M344 A347 R348 A351 Y352 Q355 Q356 R359 1.11.1.6 Q6M8A6 SEKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7f B 1.76 BS01 NDP B 1 P146 H189 Y193 R198 H230 W298 S299 Q300 Q456 L460 V464 L465 E469 P144 H187 Y191 R196 H228 W296 S297 Q298 Q454 L458 V462 L463 E467 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7f B 1.76 BS02 NO B 1 P70 H71 F156 P68 H69 F154 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7f B 1.76 BS03 HEM B 1 R68 P70 H71 R107 G126 F127 A128 V141 G142 N143 G153 F156 G211 S212 H213 L294 L329 M345 A348 R349 A352 Y353 Q356 Q357 R360 R66 P68 H69 R105 G124 F125 A126 V139 G140 N141 G151 F154 G209 S210 H211 L292 L327 M343 A346 R347 A350 Y351 Q354 Q355 R358 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7f C 1.76 BS01 NDP C 1 P146 H189 Y193 R198 H230 T297 W298 S299 Q300 Q456 L460 V464 L465 E469 P144 H187 Y191 R196 H228 T295 W296 S297 Q298 Q454 L458 V462 L463 E467 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7f C 1.76 BS02 NO C 1 P70 H71 F156 P68 H69 F154 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7f C 1.76 BS03 HEM C 1 R68 P70 H71 R107 G126 F127 V141 G142 N143 G153 F156 G211 S212 H213 L294 M345 A348 R349 A352 Y353 Q356 Q357 R360 R66 P68 H69 R105 G124 F125 V139 G140 N141 G151 F154 G209 S210 H211 L292 M343 A346 R347 A350 Y351 Q354 Q355 R358 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7f D 1.76 BS01 NDP D 1 P146 H189 Y193 R198 H230 T297 W298 S299 Q300 Q456 L460 V464 L465 E469 P144 H187 Y191 R196 H228 T295 W296 S297 Q298 Q454 L458 V462 L463 E467 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7f D 1.76 BS02 NO D 1 P70 H71 F156 Y353 P68 H69 F154 Y351 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7f D 1.76 BS03 HEM D 1 R68 P70 H71 R107 G126 A128 V141 G142 N143 G153 F156 G211 S212 H213 L294 M345 A348 R349 A352 Y353 Q356 Q357 R360 R66 P68 H69 R105 G124 A126 V139 G140 N141 G151 F154 G209 S210 H211 L292 M343 A346 R347 A350 Y351 Q354 Q355 R358 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7g A 1.90 BS01 NDP A 1 P146 H189 Y193 R198 H230 T297 W298 S299 Q300 Q456 L460 V464 L465 E469 P143 H186 Y190 R195 H227 T294 W295 S296 Q297 Q453 L457 V461 L462 E466 1.11.1.6 Q6M8A6 KSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7g A 1.90 BS02 HEM A 1 R68 P70 H71 R107 G126 F127 A128 V141 G142 N143 G153 F156 G211 S212 H213 L294 M345 R349 A352 Y353 Q356 Q357 R360 R65 P67 H68 R104 G123 F124 A125 V138 G139 N140 G150 F153 G208 S209 H210 L291 M342 R346 A349 Y350 Q353 Q354 R357 1.11.1.6 Q6M8A6 KSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7g B 1.90 BS01 NDP B 1 P146 H189 Y193 R198 H230 T297 W298 S299 Q300 Q456 L460 V464 L465 E469 P144 H187 Y191 R196 H228 T295 W296 S297 Q298 Q454 L458 V462 L463 E467 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7g B 1.90 BS02 HEM B 1 R68 P70 H71 R107 G126 F127 A128 V141 G142 N143 G153 F156 G211 S212 H213 L294 L329 M345 A348 R349 A352 Y353 Q356 Q357 R360 R66 P68 H69 R105 G124 F125 A126 V139 G140 N141 G151 F154 G209 S210 H211 L292 L327 M343 A346 R347 A350 Y351 Q354 Q355 R358 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7g C 1.90 BS01 NDP C 1 P146 H189 Y193 R198 H230 T297 W298 S299 Q300 Q456 V464 L465 E469 P143 H186 Y190 R195 H227 T294 W295 S296 Q297 Q453 V461 L462 E466 1.11.1.6 Q6M8A6 KSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7g C 1.90 BS02 HEM C 1 R68 P70 H71 R107 G126 F127 A128 V141 G142 N143 G153 F156 G211 S212 H213 L294 M345 A348 R349 A352 Y353 Q356 Q357 R360 R65 P67 H68 R104 G123 F124 A125 V138 G139 N140 G150 F153 G208 S209 H210 L291 M342 A345 R346 A349 Y350 Q353 Q354 R357 1.11.1.6 Q6M8A6 KSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7g D 1.90 BS01 NDP D 1 P146 H189 Y193 R198 F210 T297 S299 Q300 Q456 L460 V464 L465 E469 P144 H187 Y191 R196 F208 T295 S297 Q298 Q454 L458 V462 L463 E467 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7g D 1.90 BS02 HEM D 1 R68 P70 H71 R107 G126 F127 A128 V141 G142 N143 G153 F156 G211 S212 H213 L294 L329 M345 A348 R349 A352 Y353 Q356 Q357 R360 R66 P68 H69 R105 G124 F125 A126 V139 G140 N141 G151 F154 G209 S210 H211 L292 L327 M343 A346 R347 A350 Y351 Q354 Q355 R358 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7h A 1.39 BS01 HEM A 1 R68 P70 H71 R107 G126 V141 G142 N143 G153 F156 G211 S212 H213 L294 M345 A348 R349 A352 Y353 Q356 Q357 R360 R67 P69 H70 R106 G125 V140 G141 N142 G152 F155 G210 S211 H212 L293 M344 A347 R348 A351 Y352 Q355 Q356 R359 1.11.1.6 Q6M8A6 SEKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7h A 1.39 BS02 NO A 1 P70 H71 F156 P69 H70 F155 1.11.1.6 Q6M8A6 SEKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7h A 1.39 BS03 NDP A 1 P146 H189 Y193 R198 H230 T297 W298 S299 Q300 Q456 L460 V464 L465 E469 P145 H188 Y192 R197 H229 T296 W297 S298 Q299 Q455 L459 V463 L464 E468 1.11.1.6 Q6M8A6 SEKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7h B 1.39 BS01 HEM B 1 R68 P70 H71 R107 G126 A128 V141 G142 N143 G153 F156 G211 S212 H213 L294 L329 M345 A348 R349 A352 Y353 Q356 Q357 R360 R66 P68 H69 R105 G124 A126 V139 G140 N141 G151 F154 G209 S210 H211 L292 L327 M343 A346 R347 A350 Y351 Q354 Q355 R358 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7h B 1.39 BS02 NDP B 1 P146 H189 Y193 R198 H230 T297 W298 S299 Q300 K301 Q456 L460 V464 L465 E469 P144 H187 Y191 R196 H228 T295 W296 S297 Q298 K299 Q454 L458 V462 L463 E467 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7h B 1.39 BS03 NO B 1 P70 H71 F156 P68 H69 F154 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7h C 1.39 BS01 HEM C 1 R68 P70 H71 R107 G126 V141 G142 N143 G153 F156 G211 S212 H213 L294 M345 A348 R349 A352 Y353 Q356 Q357 R360 R66 P68 H69 R105 G124 V139 G140 N141 G151 F154 G209 S210 H211 L292 M343 A346 R347 A350 Y351 Q354 Q355 R358 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7h C 1.39 BS02 NDP C 1 P146 H189 Y193 R198 H230 T297 W298 S299 Q300 Q456 L460 V464 L465 E469 P144 H187 Y191 R196 H228 T295 W296 S297 Q298 Q454 L458 V462 L463 E467 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7h C 1.39 BS03 NO C 1 P70 H71 F156 P68 H69 F154 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7h D 1.39 BS01 HEM D 1 R68 P70 H71 R107 G126 V141 G142 N143 G153 F156 G211 S212 H213 L294 L329 M345 A348 R349 A352 Y353 Q356 Q357 R360 R66 P68 H69 R105 G124 V139 G140 N141 G151 F154 G209 S210 H211 L292 L327 M343 A346 R347 A350 Y351 Q354 Q355 R358 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7h D 1.39 BS02 NDP D 1 P146 H189 Y193 R198 H230 T297 W298 S299 Q300 Q456 L460 L465 E469 P144 H187 Y191 R196 H228 T295 W296 S297 Q298 Q454 L458 L463 E467 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7h D 1.39 BS03 NO D 1 P70 H71 F156 P68 H69 F154 1.11.1.6 Q6M8A6 EKSAADQIVDRGMRPKLSGNTTRHNGAPVPSENISATAGPQGPNVLNDIHLIEKLAHFNRENVPERIPHAKGHGAFGELHITEDVSEYTKADLFQPGKVTPLAVRFSTVAGEQGSPDTWRDVHGFALRFYTEEGNYDIVGNNTPTFFLRDGMKFPDFIHSQKRLNKNGLRDADMQWDFWTRAPESAHQVTYLMGDRGTPKTSRHQDGFGSHTFQWINAEGKPVWVKYHFKTRQGWDCFTDAEAAKVAGENADYQREDLYNAIENGDFPIWDVKVQIMPFEDAENYRWNPFDLTKTWSQKDYPLIPVGYFILNRNPRNFFAQIEQIALDPGNIVPGVGLSPDRMLQARIFAYADQQRYRIGANYRDLPVNRPINEVNTYSREGSMQYIFDAEGEPSYSPNRYDKGAGYLDNGTDSSSNHTSYGQADDIYVNPDPHGTDLVRAAYVKHQDDDDFIQPGILYREVLDEGEKERLADNISNAMQGISEATEPRVYDYWNNVDENLGARVKELYLQKKA 4b7s A 1.84 BS01 HEM A 1 K72 M92 L93 H100 R104 F111 I157 L240 A243 G244 T247 T248 L251 P289 V290 A293 T294 R296 A346 F347 G348 H352 C354 I355 G356 L359 A360 K63 M83 L84 H91 R95 F102 I148 L231 A234 G235 T238 T239 L242 P280 V281 A284 T285 R287 A337 F338 G339 H343 C345 I346 G347 L350 A351 O87605 ASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4b7s A 1.84 BS02 QLE A 1 W74 E85 N89 E94 F178 V179 H238 I239 V242 A243 T294 M394 I395 W65 E76 N80 E85 F169 V170 H229 I230 V233 A234 T285 M385 I386 O87605 ASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4b7s B 1.84 BS01 HEM B 1 M92 L93 H100 R104 F111 L240 A243 G244 T247 T248 L251 P289 V290 A293 T294 R296 A346 F347 G348 I351 H352 C354 I355 G356 A360 M79 L80 H87 R91 F98 L227 A230 G231 T234 T235 L238 P276 V277 A280 T281 R283 A333 F334 G335 I338 H339 C341 I342 G343 A347 O87605 VLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4b7s B 1.84 BS02 QLE B 1 E85 N89 L93 E94 F178 V179 H238 I239 V242 A243 E246 T247 T294 M394 I395 E72 N76 L80 E81 F165 V166 H225 I226 V229 A230 E233 T234 T281 M381 I382 O87605 VLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 4bki A 2.20 BS01 DI1 A 1 A653 V654 K655 E672 M676 L679 I685 T701 D702 Y703 M704 L757 V763 H764 L773 I782 A783 D784 F785 A54 V55 K56 E73 M77 L80 I86 T102 D103 Y104 M105 L143 V149 H150 L159 I168 A169 D170 F171 2.7.10.1 Q08345 MPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 4bwo A 1.80 BS01 SO4 A 1 H75 S77 S79 C97 K100 H70 S72 S74 C92 K95 Q47212 SAQVTGTLLGTGKTNTTQMPALYTWQHQIYNVNFIPSSSGTLTCQAGTILVWKNGRETQYALECRVSIHHSSGSINESQWGQQSQVGFGTACGNKKCRFTGFEISLRIPPNAQTYPLSSGDLKGSFSLTNKEVNWSASIYVP 4bwo B 1.80 BS01 SO4 B 1 H75 S77 S79 C97 K100 H70 S72 S74 C92 K95 Q47212 SAQVTGTLLGTGKTNTTQMPALYTWQHQIYNVNFIPSSSGTLTCQAGTILVWKNGRETQYALECRVSIHHSSGSINESQWGQQSQVGFGTACGNKKCRFTGFEISLRIPPNAQTYPLSSGDLKGSFSLTNKEVNWSASIYVP 4bwz A 2.98 BS01 ZN A 1 E5 E9 H51 E3 E7 H49 Q72IM4 GAEHLLEIFYLLLAAQVCAFIFKRLNQPVVIGEVLAGVLVGPALLGLVHEGEILEFLAELGAVFLLFMVGLETRLKDILAVGKEAFLVAVLGVALPFLGGYLYGLEIGFETLPALFLGTALVATSVGITARVLQELGVLSRPYSRIILGAAVIDDVLGLIVLACVNGVAETGQVEVGAITRLIVLSVVFVGLAVFLSTLIARLPLERLPVGSPLGFALALGVGMAALAASIGLAPIVGAFLGGMLLSEVREKYRLEEPIFAIESFLAPIFFAMVGVRLELSALASPVVLVAGTVVTVIAILGKVLGGFLGALTQGVRSALTVGCGMAPRGEVGLIVAALGLKAGAVNEEEYAIVLFMVVFTTLFAPFALKPLIAWTERERAAKE 4bxo A 2.15 BS01 CA A 1 D1854 E1864 R1865 D37 E47 R48 3.6.4.13 Q8IYD8 23932590 TCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDRRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQML 4bxo B 2.15 BS01 NUC H 1 K173 V199 G200 V203 Q206 K155 V181 G182 V185 Q188 Q9BTP7 23932590 VHVPLGHIVANEKWRGSQLAEEMQGKIKLIFEDGLTPDFYLSNRCCILYVTEADLVAGNGYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQP 4bxo B 2.15 BS02 NUC I 1 G168 V169 G170 K171 V172 K173 G150 V151 G152 K153 V154 K155 Q9BTP7 23932590 VHVPLGHIVANEKWRGSQLAEEMQGKIKLIFEDGLTPDFYLSNRCCILYVTEADLVAGNGYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQP 4bxo B 2.15 BS03 CA B 1 Q164 V169 Q146 V151 Q9BTP7 23932590 VHVPLGHIVANEKWRGSQLAEEMQGKIKLIFEDGLTPDFYLSNRCCILYVTEADLVAGNGYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQP 4bxo B 2.15 BS04 CA B 2 E196 V199 G200 E178 V181 G182 Q9BTP7 23932590 VHVPLGHIVANEKWRGSQLAEEMQGKIKLIFEDGLTPDFYLSNRCCILYVTEADLVAGNGYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQP 4byb B 3.35 BS01 NUC A 1 K22 P26 R96 L98 G99 T103 N104 T107 R111 K133 K147 I172 E176 K179 K16 P20 R90 L92 G93 T97 N98 T101 R105 K127 K141 I166 E170 K173 P80371 23945936 VKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFRFIEDLAMRGGTILFVGTKKQAQDIVRMEAERAGMPYVNQRWLGGMLTNFKTISQRVHRLEELEALFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLKRLPDAIFVVDPTKEAIAVREARKLFIPVIALADTDSDPDLVDYIIPGNDDAIRSIQLILSRAVDLIIQARGGVVEPSPSYALVQ 4byb C 3.35 BS01 NUC A 1 G2 N3 K4 I5 F10 R127 S154 G155 R156 E161 Q162 A163 W167 G171 R172 V173 P174 H176 T177 L178 R179 F186 T192 Y193 G194 V195 L196 G197 K199 G1 N2 K3 I4 F9 R126 S153 G154 R155 E160 Q161 A162 W166 G170 R171 V172 P173 H175 T176 L177 R178 F185 T191 Y192 G193 V194 L195 G196 K198 P80372 23945936 GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAGLARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVALNVQEVQNPNLSAPLVAQRVAEQIERRFAVRRAIKQAVQRVMESGAKGAKVIVSGRIGGAEQARTEWAAQGRVPLHTLRANIDYGFALARTTYGVLGVKAYIFLGEV 4byb D 3.35 BS01 NUC A 1 G2 R3 I5 P7 V8 C9 R10 R13 R14 K22 G23 E24 R25 K30 A32 R35 R36 Y38 P40 G41 Q42 H43 Q45 S52 Y54 A55 L58 R59 K61 Q62 R65 R66 E72 R73 Q74 N77 K84 K85 K86 V112 S113 R115 Q116 R118 Q119 R122 H123 H125 R132 V133 D134 L135 S137 R141 K151 L155 E156 E205 S208 R209 G1 R2 I4 P6 V7 C8 R9 R12 R13 K21 G22 E23 R24 K29 A31 R34 R35 Y37 P39 G40 Q41 H42 Q44 S51 Y53 A54 L57 R58 K60 Q61 R64 R65 E71 R72 Q73 N76 K83 K84 K85 V111 S112 R114 Q115 R117 Q118 R121 H122 H124 R131 V132 D133 L134 S136 R140 K150 L154 E155 E204 S207 R208 P80373 23945936 GRYIGPVCRLCRREGVKLYLKGERCYSPKCAMERRPYPPGQHGQKRARRPSDYAVRLREKQKLRRIYGISERQFRNLFEEASKKKGVTGSVFLGLLESRLDNVVYRLGFAVSRRQARQLVRHGHITVNGRRVDLPSYRVRPGDEIAVAEKSRNLELIRQNLEAMKGRKVGPWLSLDVEGMKGKFLRLPDREDLALPVNEQLVIEFYSR 4byb D 3.35 BS02 ZN D 1 C9 C12 L19 K22 C26 C31 C8 C11 L18 K21 C25 C30 P80373 23945936 GRYIGPVCRLCRREGVKLYLKGERCYSPKCAMERRPYPPGQHGQKRARRPSDYAVRLREKQKLRRIYGISERQFRNLFEEASKKKGVTGSVFLGLLESRLDNVVYRLGFAVSRRQARQLVRHGHITVNGRRVDLPSYRVRPGDEIAVAEKSRNLELIRQNLEAMKGRKVGPWLSLDVEGMKGKFLRLPDREDLALPVNEQLVIEFYSR 4byb E 3.35 BS01 NUC A 1 R14 T16 A17 R18 M19 Q20 A21 G22 R24 R25 R27 K47 P49 K57 Y60 Y61 F84 A86 K92 A94 A95 T98 I101 A102 L119 T120 K121 E122 L123 S125 R126 N127 I129 N130 Y133 R10 T12 A13 R14 M15 Q16 A17 G18 R20 R21 R23 K43 P45 K53 Y56 Y57 F80 A82 K88 A90 A91 T94 I97 A98 L115 T116 K117 E118 L119 S121 R122 N123 I125 N126 Y129 P27152 23945936 DFEEKMILIRRTARMQAGGRRFRFGALVVVGDRQGRVGLGFGKAPEVPLAVQKAGYYARRNMVEVPLQNGTIPHEIEVEFGASKIVLKPAAPGTGVIAGAVPRAILELAGVTDILTKELGSRNPINIAYATMEALRQLRTKADVERLRKG 4byb F 3.35 BS01 NUC A 1 R2 Y4 K54 E69 V72 N73 R87 V90 K92 R2 Y4 K54 E69 V72 N73 R87 V90 K92 P23370 23945936 MRRYEVNIVLNPNLDQSQLALEKEIIQRALENYGARVEKVEELGLRRLAYPIAKDPQGYFLWYQVEMPEDRVNDLARELRIRDNVRRVMVVKSQEPFLANA 4byb G 3.35 BS01 NUC A 1 A2 R3 R4 R6 A7 R10 N28 K29 I30 M31 R32 D33 G34 K36 N37 L38 R41 I42 R76 G82 Y85 R95 S98 R102 N109 R114 R115 A116 R119 W156 A1 R2 R3 R5 A6 R9 N27 K28 I29 M30 R31 D32 G33 K35 N36 L37 R40 I41 R75 G81 Y84 R94 S97 R101 N108 R113 R114 A115 R118 W155 P17291 23945936 ARRRRAEVRQLQPDLVYGDVLVTAFINKIMRDGKKNLAARIFYDACKIIQEKTGQEPLKVFKQAVENVKPRMEVRSRRVGGANYQVPMEVSPRRQQSLALRWLVQAANQRPERRAAVRIAHELMDAAEGKGGAVKKKEDVERMAEANRAYAHYRW 4byb G 3.35 BS02 NUC W 1 N84 R143 N148 N83 R142 N147 P17291 23945936 ARRRRAEVRQLQPDLVYGDVLVTAFINKIMRDGKKNLAARIFYDACKIIQEKTGQEPLKVFKQAVENVKPRMEVRSRRVGGANYQVPMEVSPRRQQSLALRWLVQAANQRPERRAAVRIAHELMDAAEGKGGAVKKKEDVERMAEANRAYAHYRW 4byb H 3.35 BS01 NUC A 1 M1 L2 T3 P5 D8 T11 R12 R14 N15 V19 A28 S29 R30 F31 K56 R75 K88 P89 G90 R91 R92 Y94 V95 G96 V97 S113 T114 S115 G128 V129 G130 G131 E132 M1 L2 T3 P5 D8 T11 R12 R14 N15 V19 A28 S29 R30 F31 K56 R75 K88 P89 G90 R91 R92 Y94 V95 G96 V97 S113 T114 S115 G128 V129 G130 G131 E132 P24319 23945936 MLTDPIADMLTRIRNATRVYKESTDVPASRFKEEILRILAREGFIKGYERVDVDGKPYLRVYLKYGPRRQGPDPRPEQVIHHIRRISKPGRRVYVGVKEIPRVRRGLGIAILSTSKGVLTDREARKLGVGGELICEVW 4byb I 3.35 BS01 NUC A 1 Q3 Y5 T7 R9 R10 K11 E12 V14 R16 Y36 Q38 G39 G67 G68 G69 K70 S71 G72 Q73 R83 R93 K97 L102 T103 R104 A106 R107 V108 V109 E110 R111 K112 K113 Y114 G115 H117 K118 R120 R121 P123 Q124 Y125 S126 K127 R128 Q2 Y4 T6 R8 R9 K10 E11 V13 R15 Y35 Q37 G38 G66 G67 G68 K69 S70 G71 Q72 R82 R92 K96 L101 T102 R103 A105 R106 V107 V108 E109 R110 K111 K112 Y113 G114 H116 K117 R119 R120 P122 Q123 Y124 S125 K126 R127 P80374 23945936 EQYYGTGRRKEAVARVFLRPGNGKVTVNGQDFNEYFQGLVRAVAALEPLRAVDALGHFDAYITVRGGGKSGQIDAIKLGIARALVQYNPDYRAKLKPLGFLTRDARVVERKKYGKHKARRAPQYSKR 4byb J 3.35 BS01 NUC A 1 R5 K7 R9 H13 S35 G36 P37 I38 P39 L40 P41 T42 R43 V44 R45 R46 T48 R51 G52 P53 F54 K55 H56 K57 S59 R60 H62 H68 R70 L71 D73 R3 K5 R7 H11 S33 G34 P35 I36 P37 L38 P39 T40 R41 V42 R43 R44 T46 R49 G50 P51 F52 K53 H54 K55 S57 R58 H60 H66 R68 L69 D71 P80375 23945936 KIRIKLRGFDHKTLDASAQKIVEAARRSGAQVSGPIPLPTRVRRFTVIRGPFKHKDSREHFELRTHNRLVDIINPNRKTIEQLMTLDLPTGVEIEIKT 4byb K 3.35 BS01 NUC A 1 Y20 N26 N27 I29 T31 D36 G37 P39 W42 S44 G46 V47 G52 S53 K55 R85 P113 V114 P115 H116 N117 C119 R120 P121 K122 K123 K124 R126 Y10 N16 N17 I19 T21 D26 G27 P29 W32 S34 G36 V37 G42 S43 K45 R75 P103 V104 P105 H106 N107 C109 R110 P111 K112 K113 K114 R116 P80376 23945936 KRQVASGRAYIHASYNNTIVTITDPDGNPITWSSGGVIGYKGSRKGTPYAAQLAALDAAKKAMAYGMQSVDVIVRGTGAGREQAIRALQASGLQVKSIVDDTPVPHNGCRPKKKFRKAS 4byb K 3.35 BS02 NUC W 1 K51 R54 K41 R44 P80376 23945936 KRQVASGRAYIHASYNNTIVTITDPDGNPITWSSGGVIGYKGSRKGTPYAAQLAALDAAKKAMAYGMQSVDVIVRGTGAGREQAIRALQASGLQVKSIVDDTPVPHNGCRPKKKFRKAS 4byb L 3.35 BS01 NUC A 1 P5 T6 N8 Q9 L10 R12 K13 R15 E16 K17 K20 K21 S22 K23 K28 G29 A30 P31 F32 R33 R34 K46 K47 N49 S50 A51 L52 R53 K54 T61 Y69 G72 E73 G74 R86 G87 V90 K91 D92 V101 V104 Y105 R113 K114 K115 S116 R117 S118 K119 Y120 G121 T122 K123 K124 P1 T2 N4 Q5 L6 R8 K9 R11 E12 K13 K16 K17 S18 K19 K24 G25 A26 P27 F28 R29 R30 K42 K43 N45 S46 A47 L48 R49 K50 T57 Y65 G68 E69 G70 R82 G83 V86 K87 D88 V97 V100 Y101 R109 K110 K111 S112 R113 S114 K115 Y116 G117 T118 K119 K120 P17293 23945936 PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGVYDAAGVKDRKKSRSKYGTKKPKEA 4byb M 3.35 BS01 NUC A 1 K13 R14 V17 T20 Y21 I22 Y23 G24 I25 G26 K27 A28 R29 R44 V74 N77 Y87 R88 R91 H92 L96 P97 V98 R99 G100 Q101 R102 T103 R104 T105 N106 A107 R108 T109 R110 K111 R114 K115 T116 K12 R13 V16 T19 Y20 I21 Y22 G23 I24 G25 K26 A27 R28 R43 V73 N76 Y86 R87 R90 H91 L95 P96 V97 R98 G99 Q100 R101 T102 R103 T104 N105 A106 R107 T108 R109 K110 R113 K114 T115 P80377 23945936 ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAEVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQRTRTNARTRKGPRKTVAG 4byb M 3.35 BS02 NUC V 1 T116 A118 G119 T115 A117 G118 P80377 23945936 ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAEVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQRTRTNARTRKGPRKTVAG 4byb N 3.35 BS01 NUC A 1 A2 R3 K4 A5 L6 E8 K9 K15 F16 K17 V18 R19 Y21 T22 C27 R29 R31 S32 Y34 R35 R41 I42 R45 E46 R57 K58 S60 W61 A1 R2 K3 A4 L5 E7 K8 K14 F15 K16 V17 R18 Y20 T21 C26 R28 R30 S31 Y33 R34 R40 I41 R44 E45 R56 K57 S59 W60 P24320 23945936 ARKALIEKAKRTPKFKVRAYTRCVRCGRARSVYRFFGLCRICLRELAHKGQLPGVRKASW 4byb O 3.35 BS01 NUC A 1 P2 K5 K8 Q9 I12 F18 D21 T22 G23 S24 Q28 L31 R35 L39 H42 H46 K48 D49 H50 H51 S52 R54 G55 M58 M59 G61 Q62 R64 R65 R68 Y69 R72 P1 K4 K7 Q8 I11 F17 D20 T21 G22 S23 Q27 L30 R34 L38 H41 H45 K47 D48 H49 H50 S51 R53 G54 M57 M58 G60 Q61 R63 R64 R67 Y68 R71 P80378 23945936 PITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHHSHRGLLMMVGQRRRLLRYLQREDPERYRALIEKLGIRG 4byb P 3.35 BS01 NUC A 1 M1 K3 R5 L6 R8 F9 G10 S11 K12 H13 N14 P15 H16 Y17 R18 D23 R25 R26 K27 R28 D29 G30 K31 Y32 I33 K35 Y38 P41 R42 K43 T44 W59 S61 V62 G63 Q65 T67 T69 R72 R75 F80 R81 Q82 M1 K3 R5 L6 R8 F9 G10 S11 K12 H13 N14 P15 H16 Y17 R18 D23 R25 R26 K27 R28 D29 G30 K31 Y32 I33 K35 Y38 P41 R42 K43 T44 W59 S61 V62 G63 Q65 T67 T69 R72 R75 F80 R81 Q82 Q5SJH3 23945936 MVKIRLARFGSKHNPHYRIVVTDARRKRDGKYIEKIGYYDPRKTTPDWLKVDVERARYWLSVGAQPTDTARRLLRQAGVFRQE 4byb Q 3.35 BS01 NUC A 1 P2 K3 S12 K14 M15 Q16 K17 T18 R25 L31 Y32 K34 K37 R38 S39 K40 K41 Y42 E61 S62 R63 P64 I65 S66 K67 R68 K69 R70 R72 K87 R91 R92 N94 Y95 S97 L98 S99 K100 P1 K2 S11 K13 M14 Q15 K16 T17 R24 L30 Y31 K33 K36 R37 S38 K39 K40 Y41 E60 S61 R62 P63 I64 S65 K66 R67 K68 R69 R71 K86 R90 R91 N93 Y94 S96 L97 S98 K99 Q5SHP7 23945936 PKKVLTGVVVSDKMQKTVTVLVERQFPHPLYGKVIKRSKKYLAHDPEEKYKLGDVVEIIESRPISKRKRFRVLRLVESGRMDLVEKYLIRRQNYESLSK 4byb R 3.35 BS01 NUC A 1 K49 I50 R53 A60 K61 Q63 R64 K68 K71 R72 R74 I75 F81 K31 I32 R35 A42 K43 Q45 R46 K50 K53 R54 R56 I57 F63 Q5SLQ0 23945936 KAKVKATLGEFDLRDYRNVEVLKRFLSETGKILPRRRTGLSAKEQRILAKTIKRARILGLLPFTEKLVRK 4byb S 3.35 BS01 NUC A 1 S4 L5 K6 K7 F10 H14 K18 W34 R36 R37 Y52 N53 G54 K55 K70 G72 E73 T77 R78 T79 R81 S1 L2 K3 K4 F7 H11 K15 W31 R33 R34 Y49 N50 G51 K52 K67 G69 E70 T74 R75 T76 R78 P80381 23945936 SLKKGVFVDDHLLEKVLELNAKGEKRLIKTWSRRSTIVPEMVGHTIAVYNGKQHVPVYITENMVGHKLGEFAPTRTYR 4byb T 3.35 BS01 NUC A 1 L10 K14 R15 H16 R17 Q18 S19 R22 R23 R25 N26 K27 A28 K29 S31 A32 K34 T35 L36 K38 K39 R57 K58 E60 S61 D64 K65 K68 S70 K74 N75 A78 R79 R80 K81 S82 R83 M85 R89 G101 G102 G103 L104 S105 L3 K7 R8 H9 R10 Q11 S12 R15 R16 R18 N19 K20 A21 K22 S24 A25 K27 T28 L29 K31 K32 R50 K51 E53 S54 D57 K58 K61 S63 K67 N68 A71 R72 R73 K74 S75 R76 M78 R82 G94 G95 G96 L97 S98 P80380 23945936 RNLSALKRHRQSLKRRLRNKAKKSAIKTLSKKAIQLAQEGKAEEALKIMRKAESLIDKAAKGSTLHKNAAARRKSRLMRKVRQLLEAAGAPLIGGGLSA 4byb Y 3.35 BS01 NUC A 1 R22 K26 K42 G43 K44 E46 P47 L48 K49 S53 R59 I60 E62 E63 R22 K26 K42 G43 K44 E46 P47 L48 K49 S53 R59 I60 E62 E63 C4ZSA5 23945936 MKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAACRYHY 4byb Y 3.35 BS02 NUC X 1 E46 L48 H50 N51 R59 E62 E63 R65 H83 Y84 E46 L48 H50 N51 R59 E62 E63 R65 H83 Y84 C4ZSA5 23945936 MKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAACRYHY 4byb Z 3.35 BS01 NUC A 1 K132 R136 K32 R36 C4ZSA5 23945936 MKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAACRYHY 4byc 0 3.35 BS01 NUC A 1 A2 H3 K4 G8 S9 T10 N12 R14 D15 S16 Q17 A18 K19 R20 V23 K24 R25 Y26 E27 Q29 R32 A33 G34 N35 I36 R39 R41 G42 T43 G54 R55 D56 F57 T58 F60 L62 F69 R77 A1 H2 K3 G7 S8 T9 N11 R13 D14 S15 Q16 A17 K18 R19 V22 K23 R24 Y25 E26 Q28 R31 A32 G33 N34 I35 R38 R40 G41 T42 G53 R54 D55 F56 T57 F59 L61 F68 R76 P60493 23945936 AHKKGLGSTRNGRDSQAKRLGVKRYEGQVVRAGNILVRQRGTRFKPGKNVGMGRDFTLFALVDGVVEFQDRGRLGRYVHVRPLA 4byc 0 3.35 BS02 NUC B 1 Q70 R72 G73 R74 L75 Q69 R71 G72 R73 L74 P60493 23945936 AHKKGLGSTRNGRDSQAKRLGVKRYEGQVVRAGNILVRQRGTRFKPGKNVGMGRDFTLFALVDGVVEFQDRGRLGRYVHVRPLA 4byc 1 3.35 BS01 NUC A 1 K3 K10 R11 P12 I13 V14 A15 N16 I18 Q19 R20 R21 K25 G29 V30 G31 K32 K33 T34 T35 I37 K39 R40 R41 Q42 Y43 P44 N45 Q47 K48 R50 R52 R61 A64 S65 H66 K69 R76 G79 E89 K92 K1 K8 R9 P10 I11 V12 A13 N14 I16 Q17 R18 R19 K23 G27 V28 G29 K30 K31 T32 T33 I35 K37 R38 R39 Q40 Y41 P42 N43 Q45 K46 R48 R50 R59 A62 S63 H64 K67 R74 G77 E87 K90 P60494 23945936 KVCEISGKRPIVANSIQRRGKAKREGGVGKKTTGISKRRQYPNLQKVRVRVAGQEITFRVAASHIPKVYELVERAKGLKLEGLSPKEIKKELL 4byc 2 3.35 BS01 NUC A 1 K2 L3 R7 L10 R14 K29 Q46 N47 H48 R51 K54 R55 A58 R59 L61 T62 N65 R69 K1 L2 R6 L9 R13 K28 Q45 N46 H47 R50 K53 R54 A57 R58 L60 T61 N64 R68 Q5SHP6 23945936 KLSEVRKQLEEARKLSPVELEKLVREKKRELMELRFQASIGQLSQNHKIRDLKRQIARLLTVLNEKRRQNA 4byc 3 3.35 BS01 NUC A 1 K10 S11 I13 G14 P16 K17 D18 K20 A21 A22 K24 A25 R29 R30 L31 P41 A42 I43 G45 N46 K49 K10 S11 I13 G14 P16 K17 D18 K20 A21 A22 K24 A25 R29 R30 L31 P41 A42 I43 G45 N46 K49 Q5SHQ6 23945936 MPRLKVKLVKSPIGYPKDQKAALKALGLRRLQQERVLEDTPAIRGNVEKVAHLVRVEVV 4byc 3 3.35 BS02 NUC B 1 K10 Y15 Q19 H52 K10 Y15 Q19 H52 Q5SHQ6 23945936 MPRLKVKLVKSPIGYPKDQKAALKALGLRRLQQERVLEDTPAIRGNVEKVAHLVRVEVV 4byc 4 3.35 BS01 NUC B 1 M1 K2 E3 H6 M1 K2 E3 H6 Q5SJE1 23945936 MKEGIHPKLVPARIICGCGNVIETYSTKPEIYVEVCSKCHPFYTGQQRFVDTEGRVE 4byc 5 3.35 BS01 NUC A 1 A2 K3 H4 P5 V6 P7 K8 K9 K10 T11 S12 K13 A14 R15 R16 D17 A18 R19 R20 S21 H22 H23 A24 T29 V31 P32 P34 P42 H43 A1 K2 H3 P4 V5 P6 K7 K8 K9 T10 S11 K12 A13 R14 R15 D16 A17 R18 R19 S20 H21 H22 A23 T28 V30 P31 P33 P41 H42 P80339 23945936 AKHPVPKKKTSKARRDARRSHHALTPPTLVPCPECKAMKPPHTVCPECGYYAGRK 4byc 6 3.35 BS01 NUC A 1 V5 K8 L10 R19 Y21 T23 E24 K25 N26 K27 T30 P31 E35 R37 K38 Y39 W42 K45 H46 K53 I54 V1 K4 L6 R15 Y17 T19 E20 K21 N22 K23 T26 P27 E31 R33 K34 Y35 W38 K41 H42 K49 I50 P35871 23945936 VRIKLLLECTECKRRNYATEKNKRNTPNKLELRKYCPWCRKHTVHREVKI 4byc 7 3.35 BS01 NUC A 1 M1 K2 R3 T4 W5 Q6 P7 N8 R9 R10 K11 R12 A13 K14 H16 G17 F18 R19 R21 M22 R23 P25 G26 R28 K29 V30 K32 R33 R34 R35 Q36 K37 G38 R39 W40 R41 M1 K2 R3 T4 W5 Q6 P7 N8 R9 R10 K11 R12 A13 K14 H16 G17 F18 R19 R21 M22 R23 P25 G26 R28 K29 V30 K32 R33 R34 R35 Q36 K37 G38 R39 W40 R41 P80340 23945936 MKRTWQPNRRKRAKTHGFRARMRTPGGRKVLKRRRQKGRWRLTPAVR 4byc 8 3.35 BS01 NUC A 1 P2 K3 M4 K5 T6 H7 K8 G9 K12 R13 K15 T17 A18 S19 K21 K26 T27 G28 K29 R30 H31 L32 N33 W34 Q35 S37 K39 I41 R42 Q43 R46 F48 V49 A51 K52 L62 Y64 P1 K2 M3 K4 T5 H6 K7 G8 K11 R12 K14 T16 A17 S18 K20 K25 T26 G27 K28 R29 H30 L31 N32 W33 Q34 S36 K38 I40 R41 Q42 R45 F47 V48 A50 K51 L61 Y63 Q5SKU1 23945936 PKMKTHKGAKKRVKITASGKVVAMKTGKRHLNWQKSGKEIRQKGRKFVLAKPEAERIKLLLPY 4byc 9 3.35 BS01 NUC A 1 M1 K2 R4 A5 S6 V7 K8 K15 V16 I17 R18 R19 H20 G21 R22 V23 Y24 P30 K31 K33 R35 Q36 G37 M1 K2 R4 A5 S6 V7 K8 K15 V16 I17 R18 R19 H20 G21 R22 V23 Y24 P30 K31 K33 R35 Q36 G37 Q5SHR2 23945936 MKVRASVKRICDKCKVIRRHGRVYVICENPKHKQRQG 4byc C 3.35 BS01 NUC A 1 K3 H4 G5 K6 R7 Y8 R9 A36 K37 F38 T41 E43 H45 K47 D167 A171 H173 P175 K206 G207 S212 Y214 T216 T218 M219 G220 S222 R224 K2 H3 G4 K5 R6 Y7 R8 A35 K36 F37 T40 E42 H44 K46 D58 A62 H64 P66 K97 G98 S103 Y105 T107 T109 M110 G111 S113 R115 Q5SLP7 23945936 PKHGKRYRALLEKVDPNKVYTIDEAARLVKELATAKFDETVEVHAKLGIDPRRSDQNDKTGAIHAPVGKASFPPEKLADNIRAFIRALEAHKPEGAKGTFLRSVYVTTTMGPSVRINPHS 4byc D 3.35 BS01 NUC A 1 K4 K7 P8 Y9 T10 P11 S12 R13 R14 F15 M16 F21 L37 K38 K39 G41 G42 R43 N44 N45 Q46 G47 R48 I49 T50 V51 R52 R54 G55 G56 H58 K59 R60 L61 Y62 R63 K68 I75 Y84 P86 N87 R88 Y97 V98 D99 G100 E101 K102 L147 E148 P149 K150 K151 K154 L155 A156 R157 A158 A159 G160 T161 Y172 L177 P178 S179 E181 R183 A199 H201 K202 V205 L206 G207 K208 A209 G210 R211 S212 R213 W214 L215 R218 P219 H220 V221 R222 G223 A224 A225 M226 N227 P228 V229 D230 H231 H233 G235 G236 E237 G238 R239 A240 P241 R242 G243 R244 P246 A247 S248 P249 W250 W252 Q253 T254 K255 G256 L257 K258 T259 R260 K261 R262 R263 K264 S266 R268 K3 K6 P7 Y8 T9 P10 S11 R12 R13 F14 M15 F20 L36 K37 K38 G40 G41 R42 N43 N44 Q45 G46 R47 I48 T49 V50 R51 R53 G54 G55 H57 K58 R59 L60 Y61 R62 K67 I74 Y83 P85 N86 R87 Y96 V97 D98 G99 E100 K101 L146 E147 P148 K149 K150 K153 L154 A155 R156 A157 A158 G159 T160 Y171 L176 P177 S178 E180 R182 A198 H200 K201 V204 L205 G206 K207 A208 G209 R210 S211 R212 W213 L214 R217 P218 H219 V220 R221 G222 A223 A224 M225 N226 P227 V228 D229 H230 H232 G234 G235 E236 G237 R238 A239 P240 R241 G242 R243 P245 A246 S247 P248 W249 W251 Q252 T253 K254 G255 L256 K257 T258 R259 K260 R261 R262 K263 S265 R267 P60405 23945936 AVKKFKPYTPSRRFMTVADFSEITKTEPEKSLVKPLKKTGGRNNQGRITVRFRGGGHKRLYRIIDFKRWDKVGIPAKVAAIEYDPNRSARIALLHYVDGEKRYIIAPDGLQVGQQVVAGPDAPIQVGNALPLRFIPVGTVVHAVELEPKKGAKLARAAGTSAQIQGREGDYVILRLPSGELRKVHGECYATVGAVGNADHKNIVLGKAGRSRWLGRRPHVRGAAMNPVDHPHGGGEGRAPRGRPPASPWGWQTKGLKTRKRRKPSSRFIIA 4byc E 3.35 BS01 NUC A 1 K8 M11 T12 R13 P22 Q35 R37 K41 D42 Y44 R58 N60 R61 K64 H66 I77 L78 R79 E80 R82 S108 K109 G110 R111 G112 F113 G115 K118 R119 F122 A123 G124 P126 D127 S128 H129 G130 A131 H132 K133 I134 H135 R136 H137 P138 G139 S140 I141 G142 N143 R144 K145 T146 P147 G148 R149 V150 Y151 K152 G153 K154 M156 A157 H159 Y160 R164 V165 T166 V167 M168 N169 K185 G186 A187 V188 P189 G190 P191 N192 K202 K203 K8 M11 T12 R13 P22 Q35 R37 K41 D42 Y44 R58 N60 R61 K64 H66 I77 L78 R79 E80 R82 S108 K109 G110 R111 G112 F113 G115 K118 R119 F122 A123 G124 P126 D127 S128 H129 G130 A131 H132 K133 I134 H135 R136 H137 P138 G139 S140 I141 G142 N143 R144 K145 T146 P147 G148 R149 V150 Y151 K152 G153 K154 M156 A157 H159 Y160 R164 V165 T166 V167 M168 N169 K185 G186 A187 V188 P189 G190 P191 N192 K202 K203 Q5SHN8 23945936 MKGILGVKVGMTRIFRDDRAVPVTVILAGPCPVVQRRTPEKDGYTAVQLGFLPQNPKRVNRPLKGHFAKAGVEPVRILREIRDFNPEGDTVTVEIFKPGERVDVTGTSKGRGFAGVMKRWNFAGGPDSHGAHKIHRHPGSIGNRKTPGRVYKGKKMAGHYGAERVTVMNLEVVDVIPEENLLLVKGAVPGPNGGLVIVRETKKA 4byc F 3.35 BS01 NUC A 1 N29 H31 L32 W34 E35 R38 Q40 L41 R44 R45 R46 T48 A49 S50 T51 K52 T53 R54 G55 V57 A58 Y59 S60 G61 R62 K63 Q67 K68 H69 G71 R72 A73 R74 H75 G76 P81 I82 F83 V84 V88 V89 F90 G91 P92 P94 R95 Y99 T100 L101 P102 K103 K104 R106 K107 K108 G134 K135 T136 K137 L140 R165 R168 N169 P171 L176 A177 E179 G180 N182 Y184 R205 N29 H31 L32 W34 E35 R38 Q40 L41 R44 R45 R46 T48 A49 S50 T51 K52 T53 R54 G55 V57 A58 Y59 S60 G61 R62 K63 Q67 K68 H69 G71 R72 A73 R74 H75 G76 P81 I82 F83 V84 V88 V89 F90 G91 P92 P94 R95 Y99 T100 L101 P102 K103 K104 R106 K107 K108 G134 K135 T136 K137 L140 R165 R168 N169 P171 L176 A177 E179 G180 N182 Y184 R205 Q5SHN9 23945936 MKEVAVYQIPVLSPSGRRELAADLPAEINPHLLWEVVRWQLAKRRRGTASTKTRGEVAYSGRKIWPQKHTGRARHGDIGAPIFVGGGVVFGPKPRDYSYTLPKKVRKKGLAMAVADRAREGKLLLVEAFAGVNGKTKEFLAWAKEAGLDGSESVLLVTGNELVRRAARNLPWVVTLAPEGLNVYDIVRTERLVMDLDAWEVFQNRIG 4byc F 3.35 BS02 MG F 1 R168 L170 V173 R168 L170 V173 Q5SHN9 23945936 MKEVAVYQIPVLSPSGRRELAADLPAEINPHLLWEVVRWQLAKRRRGTASTKTRGEVAYSGRKIWPQKHTGRARHGDIGAPIFVGGGVVFGPKPRDYSYTLPKKVRKKGLAMAVADRAREGKLLLVEAFAGVNGKTKEFLAWAKEAGLDGSESVLLVTGNELVRRAARNLPWVVTLAPEGLNVYDIVRTERLVMDLDAWEVFQNRIG 4byc G 3.35 BS01 NUC A 1 K36 N40 L43 T71 R72 A73 K74 K75 I77 N79 L82 R91 N123 S124 F125 D126 R128 N132 G134 L135 R136 G154 M155 D156 K35 N39 L42 T70 R71 A72 K73 K74 I76 N78 L81 R90 N122 S123 F124 D125 R127 N131 G133 L134 R135 G153 M154 D155 Q5SHQ0 23945936 PLDVALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDARILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWIFLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDALRGMDIAVVTTAETDEEARALLELLGFPFRK 4byc G 3.35 BS02 NUC B 1 N27 W29 E30 Q66 K67 A69 V70 T71 R91 V92 T93 R95 R96 N26 W28 E29 Q65 K66 A68 V69 T70 R90 V91 T92 R94 R95 Q5SHQ0 23945936 PLDVALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDARILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWIFLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDALRGMDIAVVTTAETDEEARALLELLGFPFRK 4byc H 3.35 BS01 NUC A 1 R59 K62 S63 H65 G66 L67 T70 N74 G108 F109 S110 K138 Q139 G142 Q143 K160 R53 K56 S57 H59 G60 L61 T64 N68 G102 F103 S104 K132 Q133 G136 Q137 K154 Q5SHQ3 23945936 LPIPVPKGVSVEVAPGRVKVKGPKGELEVPVSPEMRVVVEEGVVRVERPSDERRHKSLHGLTRTLIANAVKGVSEGYSKELLIKGIGYRARLVGRALELTVGFSHPVVVEPPEGITFEVPEPTRVRVSGIDKQKVGQVAANIRAIRKPSAYHEKGIYYAGEPVR 4byc I 3.35 BS01 NUC A 1 K22 P23 G24 Y25 R27 N28 Y29 R33 S42 K45 A46 R50 A53 K22 P23 G24 Y25 R27 N28 Y29 R33 S42 K45 A46 R50 A53 Q5SLQ1 23945936 MKVILLEPLENLGDVGQVVDVKPGYARNYLLPRGLAVLATESNLKALEARIRAQAKRLAERKAEAERLKEILENLTLTIPVRAGETKIYGSVTAKDIAEALSRQHGVTIDPKRLALEKPIKELGEYVLTYKPHPEVPIQLKVSVV 4byc N 3.35 BS01 NUC A 1 M1 K2 Y4 W13 T22 L23 G24 R25 T28 K29 T32 R35 K37 N45 F51 T63 G64 K65 K66 Q69 K70 T73 R74 Y75 S76 Y78 P79 G80 G81 L82 K83 R97 E100 H101 A102 G105 M106 L107 P108 K109 G110 P111 L112 R114 F117 K118 K121 H130 M1 K2 Y4 W13 T22 L23 G24 R25 T28 K29 T32 R35 K37 N45 F51 T63 G64 K65 K66 Q69 K70 T73 R74 Y75 S76 Y78 P79 G80 G81 L82 K83 R97 E100 H101 A102 G105 M106 L107 P108 K109 G110 P111 L112 R114 F117 K118 K121 H130 P60488 23945936 MKTYVPKQVEPRWVLIDAEGKTLGRLATKIATLLRGKHRPDWTPNVAMGDFVVVVNADKIRVTGKKLEQKIYTRYSGYPGGLKKIPLEKMLATHPERVLEHAVKGMLPKGPLGRRLFKRLKVYAGPDHPHQAQRPEKL 4byc O 3.35 BS01 NUC A 1 M1 Q3 Q5 T6 Y7 I22 R23 L25 K26 S28 N29 A30 K31 Y32 V40 S42 K44 G55 K66 K67 E68 K70 R78 N82 M1 Q3 Q5 T6 Y7 I22 R23 L25 K26 S28 N29 A30 K31 Y32 V40 S42 K44 G55 K66 K67 E68 K70 R78 N82 Q5SHP8 23945936 MIQPQTYLEVADNTGARKIMCIRVLKGSNAKYATVGDVIVASVKEAIPRGAVKEGDVVKAVVVRTKKEIKRPDGSAIRFDDNAAVIINNQLEPRGTRVFGPVARELREKGFMKIVSLAPEVL 4byc P 3.35 BS01 NUC A 1 R7 P8 N13 R15 R16 K17 R18 G20 R21 G24 S25 G26 H27 T30 A31 T32 R33 H35 K36 G37 Q38 K39 S40 R41 G43 L45 K46 D47 P48 R50 F51 E52 G53 G54 R55 S56 L59 M60 L62 P63 K64 G66 M67 Q68 G69 Q70 V71 P72 G73 E74 I75 R77 N84 R90 L105 K108 K113 L115 G116 E117 S131 K132 S133 R3 P4 N9 R11 R12 K13 R14 G16 R17 G20 S21 G22 H23 T26 A27 T28 R29 H31 K32 G33 Q34 K35 S36 R37 G39 L41 K42 D43 P44 R46 F47 E48 G49 G50 R51 S52 L55 M56 L58 P59 K60 G62 M63 Q64 G65 Q66 V67 P68 G69 E70 I71 R73 N80 R86 L101 K104 K109 L111 G112 E113 S127 K128 S129 Q5SHQ7 23945936 DLRPNPGANKRRKRVGRGPGSGHGKTATRGHKGQKSRSGGLKDPRRFEGGRSTTLMRLPKRGMQGQVPGEIKRPRYQGVNLKDLARFEGEVTPELLVRAGLLKKGYRLKILGEGEAKPLKVVAHAFSKSALEKLKAAGGEPVLLEA 4byc Q 3.35 BS01 NUC A 1 P4 R5 R6 K8 Y9 K11 Q12 Q13 R14 G15 R16 K18 K22 G23 G24 Y26 F29 A40 W41 Q46 A49 V52 R56 K63 R67 F69 D71 Y74 T75 K76 K77 E80 V81 R82 M83 G84 K85 G86 K87 G88 R101 R119 I120 H123 K124 L125 P126 K128 P4 R5 R6 K8 Y9 K11 Q12 Q13 R14 G15 R16 K18 K22 G23 G24 Y26 F29 A40 W41 Q46 A49 V52 R56 K63 R67 F69 D71 Y74 T75 K76 K77 E80 V81 R82 M83 G84 K85 G86 K87 G88 R101 R119 I120 H123 K124 L125 P126 K128 P60489 23945936 MLMPRRMKYRKQQRGRLKGATKGGDYVAFGDYGLVALEPAWITAQQIEAARVAMVRHFRRGGKIFIRIFPDKPYTKKPLEVRMGKGKGNVEGYVAVVKPGRVMFEVAGVTEEQAMEALRIAGHKLPIKTKIVRRDAYDEA 4byc Q 3.35 BS02 NUC B 1 R16 G19 R16 G19 P60489 23945936 MLMPRRMKYRKQQRGRLKGATKGGDYVAFGDYGLVALEPAWITAQQIEAARVAMVRHFRRGGKIFIRIFPDKPYTKKPLEVRMGKGKGNVEGYVAVVKPGRVMFEVAGVTEEQAMEALRIAGHKLPIKTKIVRRDAYDEA 4byc R 3.35 BS01 NUC A 1 R2 H3 L4 K5 S6 G7 R8 K9 L10 N11 R12 H13 S14 S15 H16 R17 A19 L20 R22 N23 Q24 K26 H31 I34 T35 T36 T37 K40 K42 R45 G46 D49 H50 H53 R57 L60 H61 R63 R64 L65 R68 Q71 R77 R90 Q91 G92 G93 T95 R96 K99 R104 R105 G106 D107 A109 V117 R1 H2 L3 K4 S5 G6 R7 K8 L9 N10 R11 H12 S13 S14 H15 R16 A18 L19 R21 N22 Q23 K25 H30 I33 T34 T35 T36 K39 K41 R44 G45 D48 H49 H52 R56 L59 H60 R62 R63 L64 R67 Q70 R76 R89 Q90 G91 G92 T94 R95 K98 R103 R104 G105 D106 A108 V116 Q9Z9H5 23945936 RHLKSGRKLNRHSSHRLALYRNQAKSLLTHGRITTTVPKAKELRGFVDHLIHLAKRGDLHARRLVLRDLQDVKLVRKLFDEIAPRYRDRQGGYTRVLKLAERRRGDGAPLALVELVE 4byc S 3.35 BS01 NUC A 1 R13 V14 R15 I18 K19 R20 F87 Y92 Y94 R106 E107 G108 R3 V4 R5 I8 K9 R10 F77 Y82 Y84 R96 E97 G98 Q5SHQ4 23945936 KFRVRNRIKRTGRLRLSVFRSLKHIYAQIIDDEKGVTLVSASSLALKLKGNKTEVARQVGRALAEKALALGIKQVAFDRGPYKYHGRVKALAEGAREG 4byc S 3.35 BS02 NUC B 1 R17 R25 S27 F29 S31 L32 K33 H34 Y36 Q38 D42 G45 V46 T47 A55 K62 T63 P91 Y92 K93 H95 G96 R97 R7 R15 S17 F19 S21 L22 K23 H24 Y26 Q28 D32 G35 V36 T37 A45 K52 T53 P81 Y82 K83 H85 G86 R87 Q5SHQ4 23945936 KFRVRNRIKRTGRLRLSVFRSLKHIYAQIIDDEKGVTLVSASSLALKLKGNKTEVARQVGRALAEKALALGIKQVAFDRGPYKYHGRVKALAEGAREG 4byc T 3.35 BS01 NUC A 1 N2 R3 G4 A5 R23 R51 R53 R54 N55 G56 N58 T60 I75 R93 R95 R96 A97 K98 Y100 F101 K113 K119 N2 R3 G4 A5 R23 R51 R53 R54 N55 G56 N58 T60 I75 R93 R95 R96 A97 K98 Y100 F101 K113 K119 P60490 23945936 MNRGALIKLVESRYVRTDLPEFRPGDTVRVSYKVKEGNRTRIQDFEGIVIRIRRNGFNTTFTVRKVSYGVGVERIFPLHSPLIQKIDIVQRGRARRAKLYFIRNLSDREIRRKLRADRKRIDQDRAAERAAKEEA 4byc U 3.35 BS01 NUC A 1 P2 R3 A4 K5 T6 G7 V8 V9 R10 R11 R12 K13 H14 K15 K16 K19 K22 G23 Y24 W25 G26 L27 R28 K30 S31 R33 K34 R36 E37 F40 A41 A42 Y45 A46 Y47 A48 H49 R50 K51 R52 R53 K54 R55 F57 R58 R59 W61 I62 V63 N66 R70 N75 Y76 S77 I80 H81 R92 K93 N94 P1 R2 A3 K4 T5 G6 V7 V8 R9 R10 R11 K12 H13 K14 K15 K18 K21 G22 Y23 W24 G25 L26 R27 K29 S30 R32 K33 R35 E36 F39 A40 A41 Y44 A45 Y46 A47 H48 R49 K50 R51 R52 K53 R54 F56 R57 R58 W60 I61 V62 N65 R69 N74 Y75 S76 I79 H80 R91 K92 N93 P60491 23945936 PRAKTGVVRRRKHKKILKLAKGYWGLRSKSFRKARETLFAAGNYAYAHRKRRKRDFRRLWIVRINAACRQHGLNYSTFIHGLKKAGIEVDRKNLADLAVREPQVFAELVERAKAAQG 4byc V 3.35 BS01 NUC A 1 G8 G9 K10 E23 K24 R66 K68 K69 K74 F75 K76 A77 K78 V79 Q80 Y81 R82 R83 K84 K85 G86 H87 R88 Q89 P90 G8 G9 K10 E23 K24 R66 K68 K69 K74 F75 K76 A77 K78 V79 Q80 Y81 R82 R83 K84 K85 G86 H87 R88 Q89 P90 P60492 23945936 MFAIVKTGGKQYRVEPGLKLRVEKLDAEPGATVELPVLLLGGEKTVVGTPVVEGASVVAEVLGHGRGKKILVSKFKAKVQYRRKKGHRQPYTELLIKEIRG 4byc W 3.35 BS01 NUC A 1 K4 A5 I6 A7 R8 R11 S13 R15 K16 R18 R25 N40 K41 R42 Y45 K49 S53 A56 N57 N60 N61 H62 Y75 D77 E78 G79 P80 K83 R84 P87 R88 A89 R90 G91 R92 A93 D94 I96 K97 K98 R99 H102 K4 A5 I6 A7 R8 R11 S13 R15 K16 R18 R25 N40 K41 R42 Y45 K49 S53 A56 N57 N60 N61 H62 Y75 D77 E78 G79 P80 K83 R84 P87 R88 A89 R90 G91 R92 A93 D94 I96 K97 K98 R99 H102 Q5SHP3 23945936 MEAKAIARYVRISPRKVRLVVDLIRGKSLEEARNILRYTNKRGAYFVAKVLESAAANAVNNHDMLEDRLYVKAAYVDEGPALKRVLPRARGRADIIKKRTSHITVILGEKHGK 4byc X 3.35 BS01 NUC A 1 S14 K16 K25 H31 K33 T35 K36 T37 E38 K40 N41 E44 K53 N55 T56 L57 H58 R60 K62 K63 K64 R65 L66 R68 Y69 L70 G71 K72 R73 P74 D75 K77 K78 I80 S12 K14 K23 H29 K31 T33 K34 T35 E36 K38 N39 E42 K51 N53 T54 L55 H56 R58 K60 K61 K62 R63 L64 R66 Y67 L68 G69 K70 R71 P72 D73 K75 K76 I78 Q5SHP0 23945936 TAYDVILAPVLSEKAYAGFAEGKYTFWVHPKATKTEIKNAVETAFKVKVVKVNTLHVRGKKKRLGRYLGKRPDRKKAIVQVAPGQKIEALEG 4byc Y 3.35 BS01 NUC A 1 R2 M5 V7 K9 S17 G18 K19 V30 L31 P32 K33 K34 Y35 I44 V45 K46 K47 A48 V49 R50 G59 F60 H68 S70 K71 R73 P82 R84 V85 E91 R97 R1 M4 V6 K8 S16 G17 K18 V29 L30 P31 K32 K33 Y34 I43 V44 K45 K46 A47 V48 R49 G58 F59 H67 S69 K70 R72 P81 R83 V84 E90 R96 Q5SHP9 23945936 RVKMHVKKGDTVLVASGKYKGRVGKVKEVLPKKYAVIVEGVNIVKKAVRVSPKYPQGGFIEKEAPLHASKVRPICPACGKPTRVRKKFLENGKKIRVCAK 4byc Z 3.35 BS01 NUC A 1 K46 A113 Q118 I120 I146 G147 S149 H151 E168 E169 T170 V175 P176 K44 A111 Q116 I118 I144 G145 S147 H149 E166 E167 T168 V173 P174 Q5SHZ1 23945936 YRLKAYYREGEKPSALRRAGKLPGVMYNRHLNRKVYVDLVEFDKVFRQASIHHVIVLELPDGQSLPTLVRQVNLDKRRRRPEHVDFFVLSDEPVEMYVPLRFVGTPAGVRAGGVLQEIHRDILVKVSPRNIPEFIEVDVSGLEIGDSLHASDLKLPPGVELAVSPEETIAAVVPPEDVEKLAEE 4byc Z 3.35 BS02 NUC B 1 R10 P15 R19 V27 Y29 R31 N34 R72 Q73 N75 R79 E84 H85 D87 F89 R8 P13 R17 V25 Y27 R29 N32 R70 Q71 N73 R77 E82 H83 D85 F87 Q5SHZ1 23945936 YRLKAYYREGEKPSALRRAGKLPGVMYNRHLNRKVYVDLVEFDKVFRQASIHHVIVLELPDGQSLPTLVRQVNLDKRRRRPEHVDFFVLSDEPVEMYVPLRFVGTPAGVRAGGVLQEIHRDILVKVSPRNIPEFIEVDVSGLEIGDSLHASDLKLPPGVELAVSPEETIAAVVPPEDVEKLAEE 4byd B 3.35 BS01 NUC A 1 K22 P26 R96 L98 G99 T103 N104 T107 R111 K133 I172 E176 K179 K16 P20 R90 L92 G93 T97 N98 T101 R105 K127 I166 E170 K173 P80371 23945936 VKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFRFIEDLAMRGGTILFVGTKKQAQDIVRMEAERAGMPYVNQRWLGGMLTNFKTISQRVHRLEELEALFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLKRLPDAIFVVDPTKEAIAVREARKLFIPVIALADTDSDPDLVDYIIPGNDDAIRSIQLILSRAVDLIIQARGGVVEPSPSYALVQ 4byd C 3.35 BS01 NUC A 1 G2 N3 K4 I5 F10 R127 S154 G155 R156 E161 Q162 A163 W167 G171 R172 V173 P174 H176 T177 L178 R179 F186 T192 Y193 G194 V195 L196 G197 K199 G1 N2 K3 I4 F9 R126 S153 G154 R155 E160 Q161 A162 W166 G170 R171 V172 P173 H175 T176 L177 R178 F185 T191 Y192 G193 V194 L195 G196 K198 P80372 23945936 GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAGLARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVALNVQEVQNPNLSAPLVAQRVAEQIERRFAVRRAIKQAVQRVMESGAKGAKVIVSGRIGGAEQARTEWAAQGRVPLHTLRANIDYGFALARTTYGVLGVKAYIFLGEV 4byd D 3.35 BS01 NUC A 1 G2 R3 I5 P7 V8 C9 R10 R13 R14 K22 G23 E24 R25 K30 A32 R35 R36 Y38 P40 G41 Q42 H43 Q45 S52 Y54 A55 L58 R59 K61 Q62 R65 R66 E72 R73 Q74 N77 K84 K85 K86 V112 S113 R115 Q116 R118 Q119 R122 H123 H125 R132 V133 D134 L135 S137 R141 K151 L155 E156 E205 S208 R209 G1 R2 I4 P6 V7 C8 R9 R12 R13 K21 G22 E23 R24 K29 A31 R34 R35 Y37 P39 G40 Q41 H42 Q44 S51 Y53 A54 L57 R58 K60 Q61 R64 R65 E71 R72 Q73 N76 K83 K84 K85 V111 S112 R114 Q115 R117 Q118 R121 H122 H124 R131 V132 D133 L134 S136 R140 K150 L154 E155 E204 S207 R208 P80373 23945936 GRYIGPVCRLCRREGVKLYLKGERCYSPKCAMERRPYPPGQHGQKRARRPSDYAVRLREKQKLRRIYGISERQFRNLFEEASKKKGVTGSVFLGLLESRLDNVVYRLGFAVSRRQARQLVRHGHITVNGRRVDLPSYRVRPGDEIAVAEKSRNLELIRQNLEAMKGRKVGPWLSLDVEGMKGKFLRLPDREDLALPVNEQLVIEFYSR 4byd D 3.35 BS02 ZN D 1 C9 C12 L19 K22 C26 C31 C8 C11 L18 K21 C25 C30 P80373 23945936 GRYIGPVCRLCRREGVKLYLKGERCYSPKCAMERRPYPPGQHGQKRARRPSDYAVRLREKQKLRRIYGISERQFRNLFEEASKKKGVTGSVFLGLLESRLDNVVYRLGFAVSRRQARQLVRHGHITVNGRRVDLPSYRVRPGDEIAVAEKSRNLELIRQNLEAMKGRKVGPWLSLDVEGMKGKFLRLPDREDLALPVNEQLVIEFYSR 4byd E 3.35 BS01 NUC A 1 R14 T16 A17 R18 M19 Q20 A21 G22 R24 R25 R27 F45 K47 A48 P49 K57 Y60 Y61 F84 A86 K92 A94 A95 T98 I101 A102 L119 T120 K121 E122 L123 S125 R126 N127 I129 N130 Y133 R10 T12 A13 R14 M15 Q16 A17 G18 R20 R21 R23 F41 K43 A44 P45 K53 Y56 Y57 F80 A82 K88 A90 A91 T94 I97 A98 L115 T116 K117 E118 L119 S121 R122 N123 I125 N126 Y129 Q5SHQ5 23945936 DFEEKMILIRRTARMQAGGRRFRFGALVVVGDRQGRVGLGFGKAPEVPLAVQKAGYYARRNMVEVPLQNGTIPHEIEVEFGASKIVLKPAAPGTGVIAGAVPRAILELAGVTDILTKELGSRNPINIAYATMEALRQLRTKADVERLRKG 4byd F 3.35 BS01 NUC A 1 R2 Y4 K54 E69 V72 N73 R87 V90 K92 R2 Y4 K54 E69 V72 N73 R87 V90 K92 Q5SLP8 23945936 MRRYEVNIVLNPNLDQSQLALEKEIIQRALENYGARVEKVEELGLRRLAYPIAKDPQGYFLWYQVEMPEDRVNDLARELRIRDNVRRVMVVKSQEPFLANA 4byd G 3.35 BS01 NUC A 1 A2 R3 R4 R6 A7 R10 N28 K29 I30 M31 R32 D33 G34 K36 N37 L38 R41 I42 R76 R95 S98 R102 N109 R114 R115 A116 R119 W156 A1 R2 R3 R5 A6 R9 N27 K28 I29 M30 R31 D32 G33 K35 N36 L37 R40 I41 R75 R94 S97 R101 N108 R113 R114 A115 R118 W155 P17291 23945936 ARRRRAEVRQLQPDLVYGDVLVTAFINKIMRDGKKNLAARIFYDACKIIQEKTGQEPLKVFKQAVENVKPRMEVRSRRVGGANYQVPMEVSPRRQQSLALRWLVQAANQRPERRAAVRIAHELMDAAEGKGGAVKKKEDVERMAEANRAYAHYRW 4byd G 3.35 BS02 NUC W 1 N84 Q86 R143 M144 N83 Q85 R142 M143 P17291 23945936 ARRRRAEVRQLQPDLVYGDVLVTAFINKIMRDGKKNLAARIFYDACKIIQEKTGQEPLKVFKQAVENVKPRMEVRSRRVGGANYQVPMEVSPRRQQSLALRWLVQAANQRPERRAAVRIAHELMDAAEGKGGAVKKKEDVERMAEANRAYAHYRW 4byd H 3.35 BS01 NUC A 1 M1 L2 T3 P5 D8 T11 R12 R14 N15 V19 A28 S29 R30 F31 K56 R75 K88 P89 G90 R91 R92 Y94 V95 G96 V97 S113 T114 S115 G128 V129 G130 G131 E132 M1 L2 T3 P5 D8 T11 R12 R14 N15 V19 A28 S29 R30 F31 K56 R75 K88 P89 G90 R91 R92 Y94 V95 G96 V97 S113 T114 S115 G128 V129 G130 G131 E132 Q5SHQ2 23945936 MLTDPIADMLTRIRNATRVYKESTDVPASRFKEEILRILAREGFIKGYERVDVDGKPYLRVYLKYGPRRQGPDPRPEQVIHHIRRISKPGRRVYVGVKEIPRVRRGLGIAILSTSKGVLTDREARKLGVGGELICEVW 4byd I 3.35 BS01 NUC A 1 Q3 Y5 T7 R9 R10 K11 E12 V14 R16 Y36 Q38 G39 G67 G68 G69 K70 S71 G72 Q73 R83 R93 K97 L102 T103 R104 A106 R107 V108 V109 E110 R111 K112 K113 Y114 G115 H117 K118 R120 R121 A122 P123 Q124 Y125 S126 K127 R128 Q2 Y4 T6 R8 R9 K10 E11 V13 R15 Y35 Q37 G38 G66 G67 G68 K69 S70 G71 Q72 R82 R92 K96 L101 T102 R103 A105 R106 V107 V108 E109 R110 K111 K112 Y113 G114 H116 K117 R119 R120 A121 P122 Q123 Y124 S125 K126 R127 P80374 23945936 EQYYGTGRRKEAVARVFLRPGNGKVTVNGQDFNEYFQGLVRAVAALEPLRAVDALGHFDAYITVRGGGKSGQIDAIKLGIARALVQYNPDYRAKLKPLGFLTRDARVVERKKYGKHKARRAPQYSKR 4byd J 3.35 BS01 NUC A 1 R5 K7 R9 H13 S35 G36 P37 I38 P39 L40 P41 T42 R43 V44 R45 R46 T48 R51 G52 P53 F54 K55 H56 K57 S59 R60 H62 H68 R70 L71 D73 R3 K5 R7 H11 S33 G34 P35 I36 P37 L38 P39 T40 R41 V42 R43 R44 T46 R49 G50 P51 F52 K53 H54 K55 S57 R58 H60 H66 R68 L69 D71 Q5SHN7 23945936 KIRIKLRGFDHKTLDASAQKIVEAARRSGAQVSGPIPLPTRVRRFTVIRGPFKHKDSREHFELRTHNRLVDIINPNRKTIEQLMTLDLPTGVEIEIKT 4byd K 3.35 BS01 NUC A 1 Y20 N26 N27 I29 T31 D36 G37 P39 W42 S44 G46 V47 G52 S53 K55 R85 P113 V114 P115 H116 N117 C119 R120 P121 K122 K123 K124 R126 Y10 N16 N17 I19 T21 D26 G27 P29 W32 S34 G36 V37 G42 S43 K45 R75 P103 V104 P105 H106 N107 C109 R110 P111 K112 K113 K114 R116 P80376 23945936 KRQVASGRAYIHASYNNTIVTITDPDGNPITWSSGGVIGYKGSRKGTPYAAQLAALDAAKKAMAYGMQSVDVIVRGTGAGREQAIRALQASGLQVKSIVDDTPVPHNGCRPKKKFRKAS 4byd L 3.35 BS01 NUC A 1 P5 T6 N8 Q9 L10 R12 K13 R15 E16 K17 K20 K21 S22 K23 K28 G29 A30 P31 F32 R33 R34 K46 K47 P48 N49 S50 A51 L52 R53 K54 T61 Y69 G72 E73 G74 R86 G87 V90 K91 D92 V101 V104 Y105 R113 K114 K115 S116 R117 S118 K119 Y120 G121 T122 K123 K124 P1 T2 N4 Q5 L6 R8 K9 R11 E12 K13 K16 K17 S18 K19 K24 G25 A26 P27 F28 R29 R30 K42 K43 P44 N45 S46 A47 L48 R49 K50 T57 Y65 G68 E69 G70 R82 G83 V86 K87 D88 V97 V100 Y101 R109 K110 K111 S112 R113 S114 K115 Y116 G117 T118 K119 K120 Q5SHN3 23945936 PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGVYDAAGVKDRKKSRSKYGTKKPKEA 4byd L 3.35 BS02 MG L 1 K46 K91 K42 K87 Q5SHN3 23945936 PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGVYDAAGVKDRKKSRSKYGTKKPKEA 4byd M 3.35 BS01 NUC A 1 K13 R14 V17 T20 Y21 I22 Y23 G24 I25 G26 K27 A28 R29 R44 V74 N77 Y87 R88 R91 H92 L96 P97 V98 R99 G100 Q101 R102 T103 R104 T105 N106 A107 R108 T109 R110 K111 R114 K115 T116 K12 R13 V16 T19 Y20 I21 Y22 G23 I24 G25 K26 A27 R28 R43 V73 N76 Y86 R87 R90 H91 L95 P96 V97 R98 G99 Q100 R101 T102 R103 T104 N105 A106 R107 T108 R109 K110 R113 K114 T115 P80377 23945936 ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAEVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQRTRTNARTRKGPRKTVAG 4byd M 3.35 BS02 NUC V 1 T116 A118 G119 T115 A117 G118 P80377 23945936 ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAEVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQRTRTNARTRKGPRKTVAG 4byd N 3.35 BS01 NUC A 1 A2 R3 K4 A5 L6 E8 K9 K15 F16 K17 V18 R19 Y21 T22 C27 R29 R31 S32 V33 Y34 R35 R41 I42 R45 E46 R57 K58 S60 W61 A1 R2 K3 A4 L5 E7 K8 K14 F15 K16 V17 R18 Y20 T21 C26 R28 R30 S31 V32 Y33 R34 R40 I41 R44 E45 R56 K57 S59 W60 Q5SHQ1 23945936 ARKALIEKAKRTPKFKVRAYTRCVRCGRARSVYRFFGLCRICLRELAHKGQLPGVRKASW 4byd N 3.35 BS02 ZN N 1 C24 C27 C40 C43 C23 C26 C39 C42 Q5SHQ1 23945936 ARKALIEKAKRTPKFKVRAYTRCVRCGRARSVYRFFGLCRICLRELAHKGQLPGVRKASW 4byd O 3.35 BS01 NUC A 1 P2 K5 K8 Q9 I12 F18 D21 T22 G23 S24 Q28 L31 R35 L39 H42 H46 K48 D49 H50 H51 S52 R54 G55 M58 M59 G61 Q62 R64 R65 R68 Y69 R72 P1 K4 K7 Q8 I11 F17 D20 T21 G22 S23 Q27 L30 R34 L38 H41 H45 K47 D48 H49 H50 S51 R53 G54 M57 M58 G60 Q61 R63 R64 R67 Y68 R71 Q5SJ76 23945936 PITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHHSHRGLLMMVGQRRRLLRYLQREDPERYRALIEKLGIRG 4byd P 3.35 BS01 NUC A 1 M1 K3 R5 L6 R8 F9 G10 S11 K12 H13 N14 P15 H16 Y17 R18 D23 R25 R26 K27 R28 D29 G30 K31 Y32 I33 K35 Y38 P41 R42 K43 T44 W59 S61 V62 G63 Q65 T67 T69 R72 R75 F80 R81 Q82 M1 K3 R5 L6 R8 F9 G10 S11 K12 H13 N14 P15 H16 Y17 R18 D23 R25 R26 K27 R28 D29 G30 K31 Y32 I33 K35 Y38 P41 R42 K43 T44 W59 S61 V62 G63 Q65 T67 T69 R72 R75 F80 R81 Q82 Q5SJH3 23945936 MVKIRLARFGSKHNPHYRIVVTDARRKRDGKYIEKIGYYDPRKTTPDWLKVDVERARYWLSVGAQPTDTARRLLRQAGVFRQE 4byd Q 3.35 BS01 NUC A 1 P2 K3 S12 K14 M15 Q16 K17 T18 R25 L31 Y32 K34 K37 R38 S39 K40 K41 Y42 E61 S62 R63 P64 I65 S66 K67 R68 K69 R70 R72 K87 R91 R92 N94 Y95 S97 L98 S99 K100 P1 K2 S11 K13 M14 Q15 K16 T17 R24 L30 Y31 K33 K36 R37 S38 K39 K40 Y41 E60 S61 R62 P63 I64 S65 K66 R67 K68 R69 R71 K86 R90 R91 N93 Y94 S96 L97 S98 K99 Q5SHP7 23945936 PKKVLTGVVVSDKMQKTVTVLVERQFPHPLYGKVIKRSKKYLAHDPEEKYKLGDVVEIIESRPISKRKRFRVLRLVESGRMDLVEKYLIRRQNYESLSK 4byd R 3.35 BS01 NUC A 1 K49 I50 R53 A60 K61 Q63 R64 K68 K71 R72 R74 I75 F81 K31 I32 R35 A42 K43 Q45 R46 K50 K53 R54 R56 I57 F63 Q5SLQ0 23945936 KAKVKATLGEFDLRDYRNVEVLKRFLSETGKILPRRRTGLSAKEQRILAKTIKRARILGLLPFTEKLVRK 4byd S 3.35 BS01 NUC A 1 S4 L5 K6 K7 F10 H14 K18 W34 R36 R37 Y52 N53 G54 K55 K70 G72 E73 T77 R78 T79 Y80 R81 S1 L2 K3 K4 F7 H11 K15 W31 R33 R34 Y49 N50 G51 K52 K67 G69 E70 T74 R75 T76 Y77 R78 Q5SHP2 23945936 SLKKGVFVDDHLLEKVLELNAKGEKRLIKTWSRRSTIVPEMVGHTIAVYNGKQHVPVYITENMVGHKLGEFAPTRTYR 4byd T 3.35 BS01 NUC A 1 L10 K14 R15 H16 R17 Q18 S19 R22 R23 R25 N26 K27 A28 K29 S31 A32 K34 T35 L36 K38 K39 R57 K58 E60 S61 D64 K65 K68 S70 K74 N75 A78 R79 R80 K81 S82 R83 M85 R89 G101 G102 G103 L104 S105 L3 K7 R8 H9 R10 Q11 S12 R15 R16 R18 N19 K20 A21 K22 S24 A25 K27 T28 L29 K31 K32 R50 K51 E53 S54 D57 K58 K61 S63 K67 N68 A71 R72 R73 K74 S75 R76 M78 R82 G94 G95 G96 L97 S98 P80380 23945936 RNLSALKRHRQSLKRRLRNKAKKSAIKTLSKKAIQLAQEGKAEEALKIMRKAESLIDKAAKGSTLHKNAAARRKSRLMRKVRQLLEAAGAPLIGGGLSA 4byd Y 3.35 BS01 NUC A 1 R22 K26 K42 G43 K44 E46 P47 K49 S53 R59 I60 T61 E62 E63 R22 K26 K42 G43 K44 E46 P47 K49 S53 R59 I60 T61 E62 E63 C8UCW6 23945936 MKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAACRYHY 4byd Y 3.35 BS02 NUC X 1 E46 H50 N51 L52 R59 E62 E63 R65 H83 Y84 E46 H50 N51 L52 R59 E62 E63 R65 H83 Y84 C8UCW6 23945936 MKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAACRYHY 4byd Z 3.35 BS01 NUC A 1 K32 R35 R36 K32 R35 R36 C8UCW6 23945936 MKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAACRYHY 4bye 0 3.35 BS01 NUC A 1 A2 H3 K4 G8 S9 T10 N12 R14 D15 S16 Q17 A18 K19 R20 V23 K24 R25 Y26 E27 Q29 R32 A33 G34 N35 I36 R39 R41 G42 T43 G54 R55 D56 F57 T58 F60 L62 F69 R77 A1 H2 K3 G7 S8 T9 N11 R13 D14 S15 Q16 A17 K18 R19 V22 K23 R24 Y25 E26 Q28 R31 A32 G33 N34 I35 R38 R40 G41 T42 G53 R54 D55 F56 T57 F59 L61 F68 R76 P60493 23945936 AHKKGLGSTRNGRDSQAKRLGVKRYEGQVVRAGNILVRQRGTRFKPGKNVGMGRDFTLFALVDGVVEFQDRGRLGRYVHVRPLA 4bye 0 3.35 BS02 NUC B 1 Q70 R72 G73 R74 Q69 R71 G72 R73 P60493 23945936 AHKKGLGSTRNGRDSQAKRLGVKRYEGQVVRAGNILVRQRGTRFKPGKNVGMGRDFTLFALVDGVVEFQDRGRLGRYVHVRPLA 4bye 1 3.35 BS01 NUC A 1 K3 K10 R11 P12 I13 V14 A15 N16 I18 Q19 R20 R21 K25 G28 G29 V30 G31 K32 K33 T34 T35 I37 K39 R40 R41 Q42 Y43 P44 N45 Q47 K48 R50 R52 R61 A64 S65 H66 I67 K69 R76 G79 L80 K81 E89 K1 K8 R9 P10 I11 V12 A13 N14 I16 Q17 R18 R19 K23 G26 G27 V28 G29 K30 K31 T32 T33 I35 K37 R38 R39 Q40 Y41 P42 N43 Q45 K46 R48 R50 R59 A62 S63 H64 I65 K67 R74 G77 L78 K79 E87 P60494 23945936 KVCEISGKRPIVANSIQRRGKAKREGGVGKKTTGISKRRQYPNLQKVRVRVAGQEITFRVAASHIPKVYELVERAKGLKLEGLSPKEIKKELL 4bye 2 3.35 BS01 NUC A 1 K2 L3 R7 L10 R14 K29 Q46 N47 H48 I50 R51 K54 R55 A58 R59 L61 T62 N65 K1 L2 R6 L9 R13 K28 Q45 N46 H47 I49 R50 K53 R54 A57 R58 L60 T61 N64 Q5SHP6 23945936 KLSEVRKQLEEARKLSPVELEKLVREKKRELMELRFQASIGQLSQNHKIRDLKRQIARLLTVLNEKRRQNA 4bye 3 3.35 BS01 NUC A 1 K10 S11 I13 G14 P16 K17 D18 K20 A21 A22 K24 A25 R29 R30 L31 P41 A42 I43 G45 N46 K49 K10 S11 I13 G14 P16 K17 D18 K20 A21 A22 K24 A25 R29 R30 L31 P41 A42 I43 G45 N46 K49 Q5SHQ6 23945936 MPRLKVKLVKSPIGYPKDQKAALKALGLRRLQQERVLEDTPAIRGNVEKVAHLVRVEVV 4bye 3 3.35 BS02 NUC B 1 K10 Y15 Q19 H52 K10 Y15 Q19 H52 Q5SHQ6 23945936 MPRLKVKLVKSPIGYPKDQKAALKALGLRRLQQERVLEDTPAIRGNVEKVAHLVRVEVV 4bye 4 3.35 BS01 NUC B 1 M1 K2 E3 H6 M1 K2 E3 H6 Q5SJE1 23945936 MKEGIHPKLVPARIICGCGNVIETYSTKPEIYVEVCSKCHPFYTGQQRFVDTEGRVE 4bye 5 3.35 BS01 NUC A 1 A2 K3 H4 P5 V6 P7 K8 K9 K10 T11 S12 K13 A14 R15 R16 D17 A18 R19 R20 S21 H22 H23 A24 T29 V31 P32 P34 P42 H43 A1 K2 H3 P4 V5 P6 K7 K8 K9 T10 S11 K12 A13 R14 R15 D16 A17 R18 R19 S20 H21 H22 A23 T28 V30 P31 P33 P41 H42 P80339 23945936 AKHPVPKKKTSKARRDARRSHHALTPPTLVPCPECKAMKPPHTVCPECGYYAGRK 4bye 6 3.35 BS01 NUC A 1 V5 K8 L10 R19 Y21 T23 E24 K25 N26 K27 T30 P31 E35 R37 K38 Y39 W42 K45 H46 K53 I54 V1 K4 L6 R15 Y17 T19 E20 K21 N22 K23 T26 P27 E31 R33 K34 Y35 W38 K41 H42 K49 I50 P35871 23945936 VRIKLLLECTECKRRNYATEKNKRNTPNKLELRKYCPWCRKHTVHREVKI 4bye 7 3.35 BS01 NUC A 1 M1 K2 R3 T4 W5 Q6 P7 N8 R9 R10 K11 R12 A13 K14 H16 G17 F18 R19 R21 M22 R23 P25 G26 G27 R28 K29 V30 K32 R33 R34 R35 Q36 K37 G38 R39 W40 R41 M1 K2 R3 T4 W5 Q6 P7 N8 R9 R10 K11 R12 A13 K14 H16 G17 F18 R19 R21 M22 R23 P25 G26 G27 R28 K29 V30 K32 R33 R34 R35 Q36 K37 G38 R39 W40 R41 P80340 23945936 MKRTWQPNRRKRAKTHGFRARMRTPGGRKVLKRRRQKGRWRLTPAVR 4bye 8 3.35 BS01 NUC A 1 P2 K3 M4 K5 T6 H7 K8 G9 K12 R13 K15 T17 A18 S19 K21 K26 T27 G28 K29 R30 H31 L32 N33 W34 Q35 S37 K39 I41 R42 Q43 R46 F48 V49 A51 K52 L62 Y64 P1 K2 M3 K4 T5 H6 K7 G8 K11 R12 K14 T16 A17 S18 K20 K25 T26 G27 K28 R29 H30 L31 N32 W33 Q34 S36 K38 I40 R41 Q42 R45 F47 V48 A50 K51 L61 Y63 Q5SKU1 23945936 PKMKTHKGAKKRVKITASGKVVAMKTGKRHLNWQKSGKEIRQKGRKFVLAKPEAERIKLLLPY 4bye 9 3.35 BS01 NUC A 1 M1 K2 R4 A5 S6 V7 K8 K15 V16 I17 R18 R19 H20 R22 V23 Y24 P30 K31 K33 R35 Q36 G37 M1 K2 R4 A5 S6 V7 K8 K15 V16 I17 R18 R19 H20 R22 V23 Y24 P30 K31 K33 R35 Q36 G37 Q5SHR2 23945936 MKVRASVKRICDKCKVIRRHGRVYVICENPKHKQRQG 4bye C 3.35 BS01 NUC A 1 K3 H4 G5 K6 R7 Y8 R9 A36 K37 F38 T41 E43 H45 K47 D167 A171 H173 P175 K206 G207 S212 Y214 T216 T218 M219 G220 S222 R224 K2 H3 G4 K5 R6 Y7 R8 A35 K36 F37 T40 E42 H44 K46 D58 A62 H64 P66 K97 G98 S103 Y105 T107 T109 M110 G111 S113 R115 Q5SLP7 23945936 PKHGKRYRALLEKVDPNKVYTIDEAARLVKELATAKFDETVEVHAKLGIDPRRSDQNDKTGAIHAPVGKASFPPEKLADNIRAFIRALEAHKPEGAKGTFLRSVYVTTTMGPSVRINPHS 4bye D 3.35 BS01 NUC A 1 K4 K7 P8 Y9 T10 P11 S12 R13 R14 F15 M16 F21 E30 L37 K38 K39 G41 G42 R43 N44 N45 Q46 G47 R48 I49 T50 V51 R52 R54 G55 G56 H58 K59 R60 L61 Y62 R63 K68 I75 Y84 P86 N87 R88 Y97 V98 D99 G100 E101 K102 L147 E148 P149 K150 K151 K154 L155 A156 R157 A158 A159 G160 T161 Y172 L177 P178 S179 E181 R183 A199 H201 K202 V205 L206 G207 K208 A209 G210 R211 S212 R213 W214 L215 R218 P219 H220 V221 R222 G223 A224 A225 M226 N227 P228 V229 D230 H231 H233 G235 G236 E237 G238 R239 A240 P241 R242 G243 R244 P246 A247 S248 P249 W250 W252 Q253 T254 K255 G256 L257 K258 T259 R260 K261 R262 R263 K264 S266 R268 K3 K6 P7 Y8 T9 P10 S11 R12 R13 F14 M15 F20 E29 L36 K37 K38 G40 G41 R42 N43 N44 Q45 G46 R47 I48 T49 V50 R51 R53 G54 G55 H57 K58 R59 L60 Y61 R62 K67 I74 Y83 P85 N86 R87 Y96 V97 D98 G99 E100 K101 L146 E147 P148 K149 K150 K153 L154 A155 R156 A157 A158 G159 T160 Y171 L176 P177 S178 E180 R182 A198 H200 K201 V204 L205 G206 K207 A208 G209 R210 S211 R212 W213 L214 R217 P218 H219 V220 R221 G222 A223 A224 M225 N226 P227 V228 D229 H230 H232 G234 G235 E236 G237 R238 A239 P240 R241 G242 R243 P245 A246 S247 P248 W249 W251 Q252 T253 K254 G255 L256 K257 T258 R259 K260 R261 R262 K263 S265 R267 P60405 23945936 AVKKFKPYTPSRRFMTVADFSEITKTEPEKSLVKPLKKTGGRNNQGRITVRFRGGGHKRLYRIIDFKRWDKVGIPAKVAAIEYDPNRSARIALLHYVDGEKRYIIAPDGLQVGQQVVAGPDAPIQVGNALPLRFIPVGTVVHAVELEPKKGAKLARAAGTSAQIQGREGDYVILRLPSGELRKVHGECYATVGAVGNADHKNIVLGKAGRSRWLGRRPHVRGAAMNPVDHPHGGGEGRAPRGRPPASPWGWQTKGLKTRKRRKPSSRFIIA 4bye E 3.35 BS01 NUC A 1 K8 M11 T12 R13 P22 Q35 R37 K41 D42 Y44 R58 N60 R61 K64 H66 I77 L78 R79 E80 R82 S108 K109 G110 R111 G112 F113 G115 K118 R119 F122 A123 G124 P126 D127 S128 H129 G130 A131 H132 K133 I134 H135 R136 H137 P138 G139 S140 I141 G142 N143 R144 K145 T146 P147 G148 R149 V150 Y151 K152 G153 K154 M156 A157 H159 Y160 R164 V165 T166 V167 M168 N169 K185 G186 A187 V188 P189 G190 P191 N192 K202 K203 K8 M11 T12 R13 P22 Q35 R37 K41 D42 Y44 R58 N60 R61 K64 H66 I77 L78 R79 E80 R82 S108 K109 G110 R111 G112 F113 G115 K118 R119 F122 A123 G124 P126 D127 S128 H129 G130 A131 H132 K133 I134 H135 R136 H137 P138 G139 S140 I141 G142 N143 R144 K145 T146 P147 G148 R149 V150 Y151 K152 G153 K154 M156 A157 H159 Y160 R164 V165 T166 V167 M168 N169 K185 G186 A187 V188 P189 G190 P191 N192 K202 K203 Q5SHN8 23945936 MKGILGVKVGMTRIFRDDRAVPVTVILAGPCPVVQRRTPEKDGYTAVQLGFLPQNPKRVNRPLKGHFAKAGVEPVRILREIRDFNPEGDTVTVEIFKPGERVDVTGTSKGRGFAGVMKRWNFAGGPDSHGAHKIHRHPGSIGNRKTPGRVYKGKKMAGHYGAERVTVMNLEVVDVIPEENLLLVKGAVPGPNGGLVIVRETKKA 4bye F 3.35 BS01 NUC A 1 N29 H31 L32 W34 E35 R38 Q40 L41 R44 R45 R46 T48 A49 S50 T51 K52 T53 R54 V57 A58 Y59 S60 G61 R62 K63 W65 Q67 K68 H69 G71 R72 A73 R74 H75 G76 P81 I82 F83 V84 V88 V89 F90 G91 P92 P94 R95 Y99 T100 L101 P102 K103 K104 R106 K107 K108 G134 K135 T136 K137 L140 R165 R168 N169 P171 L176 A177 E179 G180 N182 Y184 R205 N29 H31 L32 W34 E35 R38 Q40 L41 R44 R45 R46 T48 A49 S50 T51 K52 T53 R54 V57 A58 Y59 S60 G61 R62 K63 W65 Q67 K68 H69 G71 R72 A73 R74 H75 G76 P81 I82 F83 V84 V88 V89 F90 G91 P92 P94 R95 Y99 T100 L101 P102 K103 K104 R106 K107 K108 G134 K135 T136 K137 L140 R165 R168 N169 P171 L176 A177 E179 G180 N182 Y184 R205 Q5SHN9 23945936 MKEVAVYQIPVLSPSGRRELAADLPAEINPHLLWEVVRWQLAKRRRGTASTKTRGEVAYSGRKIWPQKHTGRARHGDIGAPIFVGGGVVFGPKPRDYSYTLPKKVRKKGLAMAVADRAREGKLLLVEAFAGVNGKTKEFLAWAKEAGLDGSESVLLVTGNELVRRAARNLPWVVTLAPEGLNVYDIVRTERLVMDLDAWEVFQNRIG 4bye F 3.35 BS02 MG F 1 R168 L170 V173 R168 L170 V173 Q5SHN9 23945936 MKEVAVYQIPVLSPSGRRELAADLPAEINPHLLWEVVRWQLAKRRRGTASTKTRGEVAYSGRKIWPQKHTGRARHGDIGAPIFVGGGVVFGPKPRDYSYTLPKKVRKKGLAMAVADRAREGKLLLVEAFAGVNGKTKEFLAWAKEAGLDGSESVLLVTGNELVRRAARNLPWVVTLAPEGLNVYDIVRTERLVMDLDAWEVFQNRIG 4bye G 3.35 BS01 NUC A 1 K36 V38 N40 G42 L43 G44 E45 T71 R72 A73 K74 K75 I77 N79 G89 L90 R91 T93 D126 R128 N132 L133 G134 L135 R136 G154 M155 D156 V160 K35 V37 N39 G41 L42 G43 E44 T70 R71 A72 K73 K74 I76 N78 G88 L89 R90 T92 D125 R127 N131 L132 G133 L134 R135 G153 M154 D155 V159 Q5SHQ0 23945936 PLDVALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDARILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWIFLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDALRGMDIAVVTTAETDEEARALLELLGFPFRK 4bye G 3.35 BS02 NUC B 1 N27 W29 E30 K67 V70 T71 R91 V92 R96 N26 W28 E29 K66 V69 T70 R90 V91 R95 Q5SHQ0 23945936 PLDVALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDARILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWIFLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDALRGMDIAVVTTAETDEEARALLELLGFPFRK 4bye H 3.35 BS01 NUC A 1 R59 K62 S63 H65 G66 L67 T70 N74 G108 F109 S110 K138 Q139 G142 Q143 K160 R53 K56 S57 H59 G60 L61 T64 N68 G102 F103 S104 K132 Q133 G136 Q137 K154 Q5SHQ3 23945936 LPIPVPKGVSVEVAPGRVKVKGPKGELEVPVSPEMRVVVEEGVVRVERPSDERRHKSLHGLTRTLIANAVKGVSEGYSKELLIKGIGYRARLVGRALELTVGFSHPVVVEPPEGITFEVPEPTRVRVSGIDKQKVGQVAANIRAIRKPSAYHEKGIYYAGEPVR 4bye I 3.35 BS01 NUC A 1 K22 P23 G24 Y25 R27 N28 Y29 R33 S42 K45 A46 R50 A53 K22 P23 G24 Y25 R27 N28 Y29 R33 S42 K45 A46 R50 A53 Q5SLQ1 23945936 MKVILLEPLENLGDVGQVVDVKPGYARNYLLPRGLAVLATESNLKALEARIRAQAKRLAERKAEAERLKEILENLTLTIPVRAGETKIYGSVTAKDIAEALSRQHGVTIDPKRLALEKPIKELGEYVLTYKPHPEVPIQLKVSVV 4bye N 3.35 BS01 NUC A 1 M1 K2 Y4 W13 T22 L23 G24 R25 T28 K29 T32 R35 K37 N45 F51 T63 G64 K65 K66 Q69 K70 T73 R74 Y75 S76 Y78 P79 G80 G81 L82 K83 R97 E100 H101 A102 G105 M106 L107 P108 K109 G110 P111 L112 R114 R115 F117 K118 K121 H130 M1 K2 Y4 W13 T22 L23 G24 R25 T28 K29 T32 R35 K37 N45 F51 T63 G64 K65 K66 Q69 K70 T73 R74 Y75 S76 Y78 P79 G80 G81 L82 K83 R97 E100 H101 A102 G105 M106 L107 P108 K109 G110 P111 L112 R114 R115 F117 K118 K121 H130 P60488 23945936 MKTYVPKQVEPRWVLIDAEGKTLGRLATKIATLLRGKHRPDWTPNVAMGDFVVVVNADKIRVTGKKLEQKIYTRYSGYPGGLKKIPLEKMLATHPERVLEHAVKGMLPKGPLGRRLFKRLKVYAGPDHPHQAQRPEKL 4bye O 3.35 BS01 NUC A 1 M1 Q3 Q5 T6 Y7 I22 R23 L25 K26 S28 N29 A30 K31 Y32 V40 S42 K44 G55 K66 K67 E68 K70 R78 N82 M1 Q3 Q5 T6 Y7 I22 R23 L25 K26 S28 N29 A30 K31 Y32 V40 S42 K44 G55 K66 K67 E68 K70 R78 N82 Q5SHP8 23945936 MIQPQTYLEVADNTGARKIMCIRVLKGSNAKYATVGDVIVASVKEAIPRGAVKEGDVVKAVVVRTKKEIKRPDGSAIRFDDNAAVIINNQLEPRGTRVFGPVARELREKGFMKIVSLAPEVL 4bye P 3.35 BS01 NUC A 1 R7 P8 N13 R15 R16 K17 R18 G20 R21 G24 S25 G26 H27 T30 A31 T32 R33 H35 K36 G37 Q38 K39 S40 R41 S42 G43 L45 K46 D47 P48 R50 F51 E52 G53 G54 R55 S56 L59 M60 L62 P63 K64 R65 G66 M67 Q68 G69 Q70 V71 P72 G73 E74 I75 R77 N84 R90 L105 K108 K113 L115 G116 E117 S131 K132 S133 R3 P4 N9 R11 R12 K13 R14 G16 R17 G20 S21 G22 H23 T26 A27 T28 R29 H31 K32 G33 Q34 K35 S36 R37 S38 G39 L41 K42 D43 P44 R46 F47 E48 G49 G50 R51 S52 L55 M56 L58 P59 K60 R61 G62 M63 Q64 G65 Q66 V67 P68 G69 E70 I71 R73 N80 R86 L101 K104 K109 L111 G112 E113 S127 K128 S129 Q5SHQ7 23945936 DLRPNPGANKRRKRVGRGPGSGHGKTATRGHKGQKSRSGGLKDPRRFEGGRSTTLMRLPKRGMQGQVPGEIKRPRYQGVNLKDLARFEGEVTPELLVRAGLLKKGYRLKILGEGEAKPLKVVAHAFSKSALEKLKAAGGEPVLLEA 4bye Q 3.35 BS01 NUC A 1 P4 R5 R6 K8 Y9 K11 Q12 Q13 R14 G15 R16 K18 K22 G23 G24 Y26 F29 A40 W41 Q46 A49 V52 R56 K63 R67 F69 D71 Y74 T75 K76 K77 E80 V81 R82 M83 G84 K85 G86 K87 G88 R101 R119 I120 H123 K124 L125 P126 K128 P4 R5 R6 K8 Y9 K11 Q12 Q13 R14 G15 R16 K18 K22 G23 G24 Y26 F29 A40 W41 Q46 A49 V52 R56 K63 R67 F69 D71 Y74 T75 K76 K77 E80 V81 R82 M83 G84 K85 G86 K87 G88 R101 R119 I120 H123 K124 L125 P126 K128 P60489 23945936 MLMPRRMKYRKQQRGRLKGATKGGDYVAFGDYGLVALEPAWITAQQIEAARVAMVRHFRRGGKIFIRIFPDKPYTKKPLEVRMGKGKGNVEGYVAVVKPGRVMFEVAGVTEEQAMEALRIAGHKLPIKTKIVRRDAYDEA 4bye Q 3.35 BS02 NUC B 1 R16 G19 R16 G19 P60489 23945936 MLMPRRMKYRKQQRGRLKGATKGGDYVAFGDYGLVALEPAWITAQQIEAARVAMVRHFRRGGKIFIRIFPDKPYTKKPLEVRMGKGKGNVEGYVAVVKPGRVMFEVAGVTEEQAMEALRIAGHKLPIKTKIVRRDAYDEA 4bye R 3.35 BS01 NUC A 1 R2 H3 L4 K5 S6 G7 R8 K9 L10 N11 R12 H13 S14 S15 H16 R17 A19 L20 R22 N23 Q24 K26 H31 I34 T35 T36 T37 K40 K42 R45 G46 D49 H50 H53 R57 L60 H61 R63 R64 L65 R68 Q71 R77 R90 Q91 G92 G93 T95 R96 K99 R104 R105 G106 D107 A109 V117 R1 H2 L3 K4 S5 G6 R7 K8 L9 N10 R11 H12 S13 S14 H15 R16 A18 L19 R21 N22 Q23 K25 H30 I33 T34 T35 T36 K39 K41 R44 G45 D48 H49 H52 R56 L59 H60 R62 R63 L64 R67 Q70 R76 R89 Q90 G91 G92 T94 R95 K98 R103 R104 G105 D106 A108 V116 Q9Z9H5 23945936 RHLKSGRKLNRHSSHRLALYRNQAKSLLTHGRITTTVPKAKELRGFVDHLIHLAKRGDLHARRLVLRDLQDVKLVRKLFDEIAPRYRDRQGGYTRVLKLAERRRGDGAPLALVELVE 4bye S 3.35 BS01 NUC A 1 R13 V14 R15 I18 K19 R20 F87 Y92 Y94 R106 E107 G108 R3 V4 R5 I8 K9 R10 F77 Y82 Y84 R96 E97 G98 Q5SHQ4 23945936 KFRVRNRIKRTGRLRLSVFRSLKHIYAQIIDDEKGVTLVSASSLALKLKGNKTEVARQVGRALAEKALALGIKQVAFDRGPYKYHGRVKALAEGAREG 4bye S 3.35 BS02 NUC B 1 R17 R25 S27 F29 S31 L32 K33 H34 Y36 Q38 D42 G45 V46 T47 N61 K62 T63 P91 Y92 K93 H95 G96 R97 R7 R15 S17 F19 S21 L22 K23 H24 Y26 Q28 D32 G35 V36 T37 N51 K52 T53 P81 Y82 K83 H85 G86 R87 Q5SHQ4 23945936 KFRVRNRIKRTGRLRLSVFRSLKHIYAQIIDDEKGVTLVSASSLALKLKGNKTEVARQVGRALAEKALALGIKQVAFDRGPYKYHGRVKALAEGAREG 4bye T 3.35 BS01 NUC A 1 N2 R3 G4 A5 R23 R51 R53 R54 N55 G56 N58 T60 I75 R93 R95 R96 A97 K98 Y100 F101 K113 K119 N2 R3 G4 A5 R23 R51 R53 R54 N55 G56 N58 T60 I75 R93 R95 R96 A97 K98 Y100 F101 K113 K119 P60490 23945936 MNRGALIKLVESRYVRTDLPEFRPGDTVRVSYKVKEGNRTRIQDFEGIVIRIRRNGFNTTFTVRKVSYGVGVERIFPLHSPLIQKIDIVQRGRARRAKLYFIRNLSDREIRRKLRADRKRIDQDRAAERAAKEEA 4bye U 3.35 BS01 NUC A 1 P2 R3 A4 K5 T6 G7 V8 R10 R11 R12 K13 H14 K15 K16 K19 K22 G23 Y24 W25 G26 L27 R28 K30 S31 R33 K34 R36 E37 F40 A42 Y45 A46 Y47 A48 H49 R50 K51 R52 R53 K54 R55 F57 R58 R59 W61 I62 V63 N66 R70 N75 Y76 S77 I80 H81 K84 R92 K93 N94 P1 R2 A3 K4 T5 G6 V7 R9 R10 R11 K12 H13 K14 K15 K18 K21 G22 Y23 W24 G25 L26 R27 K29 S30 R32 K33 R35 E36 F39 A41 Y44 A45 Y46 A47 H48 R49 K50 R51 R52 K53 R54 F56 R57 R58 W60 I61 V62 N65 R69 N74 Y75 S76 I79 H80 K83 R91 K92 N93 P60491 23945936 PRAKTGVVRRRKHKKILKLAKGYWGLRSKSFRKARETLFAAGNYAYAHRKRRKRDFRRLWIVRINAACRQHGLNYSTFIHGLKKAGIEVDRKNLADLAVREPQVFAELVERAKAAQG 4bye V 3.35 BS01 NUC A 1 G8 G9 K10 E23 K24 R66 K68 K69 K74 F75 K76 A77 K78 V79 Q80 Y81 R82 R83 K84 K85 G86 H87 R88 Q89 P90 G8 G9 K10 E23 K24 R66 K68 K69 K74 F75 K76 A77 K78 V79 Q80 Y81 R82 R83 K84 K85 G86 H87 R88 Q89 P90 P60492 23945936 MFAIVKTGGKQYRVEPGLKLRVEKLDAEPGATVELPVLLLGGEKTVVGTPVVEGASVVAEVLGHGRGKKILVSKFKAKVQYRRKKGHRQPYTELLIKEIRG 4bye W 3.35 BS01 NUC A 1 K4 A5 I6 A7 R8 R11 S13 R15 K16 R18 R25 N40 K41 R42 Y45 K49 S53 A56 N57 N60 N61 H62 Y75 D77 E78 G79 P80 K83 R84 P87 R88 A89 R90 G91 R92 A93 D94 I96 K97 K98 R99 H102 K4 A5 I6 A7 R8 R11 S13 R15 K16 R18 R25 N40 K41 R42 Y45 K49 S53 A56 N57 N60 N61 H62 Y75 D77 E78 G79 P80 K83 R84 P87 R88 A89 R90 G91 R92 A93 D94 I96 K97 K98 R99 H102 Q5SHP3 23945936 MEAKAIARYVRISPRKVRLVVDLIRGKSLEEARNILRYTNKRGAYFVAKVLESAAANAVNNHDMLEDRLYVKAAYVDEGPALKRVLPRARGRADIIKKRTSHITVILGEKHGK 4bye X 3.35 BS01 NUC A 1 S14 K16 K25 H31 K33 T35 K36 T37 E38 K40 N41 E44 K53 N55 T56 L57 H58 R60 K62 K63 K64 R65 L66 R68 Y69 L70 G71 K72 R73 P74 D75 K77 K78 I80 S12 K14 K23 H29 K31 T33 K34 T35 E36 K38 N39 E42 K51 N53 T54 L55 H56 R58 K60 K61 K62 R63 L64 R66 Y67 L68 G69 K70 R71 P72 D73 K75 K76 I78 Q5SHP0 23945936 TAYDVILAPVLSEKAYAGFAEGKYTFWVHPKATKTEIKNAVETAFKVKVVKVNTLHVRGKKKRLGRYLGKRPDRKKAIVQVAPGQKIEALEG 4bye Y 3.35 BS01 NUC A 1 R2 M5 V7 K9 S17 G18 K19 V30 L31 P32 K33 K34 Y35 I44 V45 K46 K47 A48 V49 R50 G59 F60 H68 S70 K71 R73 P82 R84 V85 E91 R97 R1 M4 V6 K8 S16 G17 K18 V29 L30 P31 K32 K33 Y34 I43 V44 K45 K46 A47 V48 R49 G58 F59 H67 S69 K70 R72 P81 R83 V84 E90 R96 Q5SHP9 23945936 RVKMHVKKGDTVLVASGKYKGRVGKVKEVLPKKYAVIVEGVNIVKKAVRVSPKYPQGGFIEKEAPLHASKVRPICPACGKPTRVRKKFLENGKKIRVCAK 4bye Z 3.35 BS01 NUC A 1 K46 R80 I146 G147 H151 E168 T170 V175 P176 K44 R78 I144 G145 H149 E166 T168 V173 P174 Q5SHZ1 23945936 YRLKAYYREGEKPSALRRAGKLPGVMYNRHLNRKVYVDLVEFDKVFRQASIHHVIVLELPDGQSLPTLVRQVNLDKRRRRPEHVDFFVLSDEPVEMYVPLRFVGTPAGVRAGGVLQEIHRDILVKVSPRNIPEFIEVDVSGLEIGDSLHASDLKLPPGVELAVSPEETIAAVVPPEDVEKLAEE 4bye Z 3.35 BS02 NUC B 1 R10 P15 R19 V27 Y29 N30 R31 R72 Q73 R79 E84 H85 D87 R8 P13 R17 V25 Y27 N28 R29 R70 Q71 R77 E82 H83 D85 Q5SHZ1 23945936 YRLKAYYREGEKPSALRRAGKLPGVMYNRHLNRKVYVDLVEFDKVFRQASIHHVIVLELPDGQSLPTLVRQVNLDKRRRRPEHVDFFVLSDEPVEMYVPLRFVGTPAGVRAGGVLQEIHRDILVKVSPRNIPEFIEVDVSGLEIGDSLHASDLKLPPGVELAVSPEETIAAVVPPEDVEKLAEE 4eqc A 2.01 BS01 XR1 A 1 A297 I298 R299 E315 I316 M319 V342 M344 E345 Y346 L347 G350 D354 L396 T406 T541 A53 I54 R55 E71 I72 M75 V98 M100 E101 Y102 L103 G106 D110 L152 T162 T297 2.7.11.1 Q13153 DPFTSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT 4fdk A 2.10 BS01 HEM A 1 M1 K2 T4 I5 W9 I75 L78 F82 Y85 F86 F94 L95 M98 V101 H102 L105 T106 T113 P114 P115 L117 M129 Y131 S133 R135 M137 Y140 F141 L144 I145 S148 M1 K2 T4 I5 W9 I75 L78 F82 Y85 F86 F94 L95 M98 V101 H102 L105 T106 T113 P114 P115 L117 M129 Y131 S133 R135 M137 Y140 F141 L144 I145 S148 Q8RBX6 23831583 MKGTIVGTWIKTLRDLYGNDVVDESLKSVGWEPDRVITPLEDIDDDEVRRIFAKVSEKTGKNVNEIWREVGRQNIKTLSEWFPSYFAGRRLVNFLMMMDEVHLQLTKMIKGATPPRLIAKPVAKDAIEMEYVSKRKMYDYFLGLIEGSSKFFKEEISVEEVERGEKDGFSRLKVRIKFKNPVFEYKKN 4fdk A 2.10 BS02 OXY A 1 I5 Y140 L144 I5 Y140 L144 Q8RBX6 23831583 MKGTIVGTWIKTLRDLYGNDVVDESLKSVGWEPDRVITPLEDIDDDEVRRIFAKVSEKTGKNVNEIWREVGRQNIKTLSEWFPSYFAGRRLVNFLMMMDEVHLQLTKMIKGATPPRLIAKPVAKDAIEMEYVSKRKMYDYFLGLIEGSSKFFKEEISVEEVERGEKDGFSRLKVRIKFKNPVFEYKKN 4fdk B 2.10 BS01 HEM B 1 M1 K2 I5 W9 I75 L78 F82 Y85 F86 F94 L95 M98 V101 H102 L105 T113 P114 P115 L117 M129 Y131 S133 R135 M137 Y140 F141 L144 I145 S148 M1 K2 I5 W9 I75 L78 F82 Y85 F86 F94 L95 M98 V101 H102 L105 T113 P114 P115 L117 M129 Y131 S133 R135 M137 Y140 F141 L144 I145 S148 Q8RBX6 23831583 MKGTIVGTWIKTLRDLYGNDVVDESLKSVGWEPDRVITPLEDIDDDEVRRIFAKVSEKTGKNVNEIWREVGRQNIKTLSEWFPSYFAGRRLVNFLMMMDEVHLQLTKMIKGATPPRLIAKPVAKDAIEMEYVSKRKMYDYFLGLIEGSSKFFKEEISVEEVERGEKDGFSRLKVRIKFKNPVFEYKKN 4fdk B 2.10 BS02 OXY B 1 I5 Y140 L144 I5 Y140 L144 Q8RBX6 23831583 MKGTIVGTWIKTLRDLYGNDVVDESLKSVGWEPDRVITPLEDIDDDEVRRIFAKVSEKTGKNVNEIWREVGRQNIKTLSEWFPSYFAGRRLVNFLMMMDEVHLQLTKMIKGATPPRLIAKPVAKDAIEMEYVSKRKMYDYFLGLIEGSSKFFKEEISVEEVERGEKDGFSRLKVRIKFKNPVFEYKKN 4g5h A 1.88 BS01 NAP A 1 G11 T13 G14 S15 F16 S36 R37 D38 K41 D60 V61 A80 A81 A82 K84 L122 S123 T124 K138 Y164 G165 S170 G20 T22 G23 S24 F25 S45 R46 D47 K50 D69 V70 A89 A90 A91 K93 L131 S132 T133 K147 Y173 G174 S179 4.2.1.115 Q7A2Y4 GLVPRGSAMGFDDKILLITGGTGSFGNAVMKRFLDSNIKEIRIFSRDEKKQDDIRKKYNNSKLKFYIGDVRDSQSVETAMRDVDYVFHAAALKQVPSCEFFPVEAVKTNIIGTENVLQSAIHQNVKKVICLSTDKAAYPINAMGISKAMMEKVFVAKSRNIRSEQTLICGTRYGNVMASRGSVIPLFIDKIKAGEPLTITDPDMTRFLMSLEDAVELVVHAFKHAETGDIMVQKAPSSTVGDLATALLELFEADNAIEIIGTRHGEKKAETLLTREEYAQCEDMGDYFRVPADSRDLNYSNYVETGNEKITQSYEYNSDNTHILTVEEIKEKLLTLEYVRNELNDY 4g5h A 1.88 BS02 UD7 A 1 K84 Q85 V86 P87 K126 N166 S173 V174 L177 T189 I190 T191 M195 V231 R254 E257 K93 Q94 V95 P96 K135 N175 S182 V183 L186 T198 I199 T200 M204 V240 R263 E266 4.2.1.115 Q7A2Y4 GLVPRGSAMGFDDKILLITGGTGSFGNAVMKRFLDSNIKEIRIFSRDEKKQDDIRKKYNNSKLKFYIGDVRDSQSVETAMRDVDYVFHAAALKQVPSCEFFPVEAVKTNIIGTENVLQSAIHQNVKKVICLSTDKAAYPINAMGISKAMMEKVFVAKSRNIRSEQTLICGTRYGNVMASRGSVIPLFIDKIKAGEPLTITDPDMTRFLMSLEDAVELVVHAFKHAETGDIMVQKAPSSTVGDLATALLELFEADNAIEIIGTRHGEKKAETLLTREEYAQCEDMGDYFRVPADSRDLNYSNYVETGNEKITQSYEYNSDNTHILTVEEIKEKLLTLEYVRNELNDY 4g5h A 1.88 BS03 UD7 A 2 Y269 S304 Y305 E306 Y307 N311 Y278 S313 Y314 E315 Y316 N320 4.2.1.115 Q7A2Y4 GLVPRGSAMGFDDKILLITGGTGSFGNAVMKRFLDSNIKEIRIFSRDEKKQDDIRKKYNNSKLKFYIGDVRDSQSVETAMRDVDYVFHAAALKQVPSCEFFPVEAVKTNIIGTENVLQSAIHQNVKKVICLSTDKAAYPINAMGISKAMMEKVFVAKSRNIRSEQTLICGTRYGNVMASRGSVIPLFIDKIKAGEPLTITDPDMTRFLMSLEDAVELVVHAFKHAETGDIMVQKAPSSTVGDLATALLELFEADNAIEIIGTRHGEKKAETLLTREEYAQCEDMGDYFRVPADSRDLNYSNYVETGNEKITQSYEYNSDNTHILTVEEIKEKLLTLEYVRNELNDY 4gq0 A 2.10 BS01 QAP A 1 W21 Y49 H111 F123 P124 K125 A131 V301 L302 W23 Y51 H113 F125 P126 K127 A133 V303 L304 1.1.1.- O60218 SHMATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFDAEY 4gq0 A 2.10 BS02 NAP A 1 G19 T20 W21 K22 D44 Y49 H111 S160 N161 Q184 Y210 S211 P212 L213 G214 S215 P216 D217 A246 I261 P262 K263 S264 V265 T266 R269 E272 N273 G21 T22 W23 K24 D46 Y51 H113 S162 N163 Q186 Y212 S213 P214 L215 G216 S217 P218 D219 A248 I263 P264 K265 S266 V267 T268 R271 E274 N275 1.1.1.- O60218 SHMATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFDAEY 4gqg A 1.92 BS01 NAP A 1 G19 T20 W21 K22 D44 Y49 H111 S160 N161 Q184 Y210 S211 P212 L213 G214 S215 P216 D217 A246 I261 P262 K263 S264 V265 T266 R269 E272 N273 C299 G21 T22 W23 K24 D46 Y51 H113 S162 N163 Q186 Y212 S213 P214 L215 G216 S217 P218 D219 A248 I263 P264 K265 S266 V267 T268 R271 E274 N275 C301 1.1.1.- O60218 SHMATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFDAEY 4gqu A 2.02 BS01 MN A 1 H73 E77 H152 H64 E68 H143 4.2.1.19 P64368 SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRV 4gqu A 2.02 BS02 MN A 2 H47 H176 E180 H38 H167 E171 4.2.1.19 P64368 SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRV 4grb A 2.15 BS01 0XG A 1 R43 V53 V66 I95 F113 V116 N118 M163 I174 D175 R42 V52 V65 I94 F112 V115 N117 M162 I173 D174 2.7.11.1 P68400 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 4gs8 A 2.99 BS01 MGJ A 1 H332 G335 H336 G339 E341 L359 V360 G361 Y609 H290 G293 H294 G297 E299 L317 V318 G319 Y567 3.4.24.56 P14735 NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gs8 A 2.99 BS02 ZN A 1 H108 H112 E189 H66 H70 E147 3.4.24.56 P14735 NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gs8 B 2.99 BS01 MGJ B 1 H332 G339 E341 L359 V360 G361 H290 G297 E299 L317 V318 G319 3.4.24.56 P14735 NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gs8 B 2.99 BS02 ZN B 1 H108 H112 E189 H66 H70 E147 3.4.24.56 P14735 NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gsc A 2.81 BS01 ZN A 1 H108 H112 E189 H67 H71 E148 3.4.24.56 P14735 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gsc A 2.81 BS02 MGW A 1 H332 G339 E341 L359 V360 G361 Y609 H291 G298 E300 L318 V319 G320 Y568 3.4.24.56 P14735 MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gsc B 2.81 BS01 ZN B 1 H108 H112 E189 H65 H69 E146 3.4.24.56 P14735 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gsc B 2.81 BS02 MGW B 1 G335 H336 G339 E341 L359 V360 G361 G292 H293 G296 E298 L316 V317 G318 3.4.24.56 P14735 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gse A 3.29 BS01 ZN A 1 H108 H112 E189 H66 H70 E147 3.4.24.56 P14735 NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gse B 3.29 BS01 ZN B 1 H108 H112 E189 H66 H70 E147 3.4.24.56 P14735 NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDLSQAPALPQPEVIQNMTEFKRGLPLFPLVKP 4gse B 3.29 BS02 OBD B 1 H108 E111 H112 S128 N139 A140 E189 R824 Y831 F834 H66 E69 H70 S86 N97 A98 E147 R782 Y789 F792 3.4.24.56 P14735 NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDLSQAPALPQPEVIQNMTEFKRGLPLFPLVKP 4gsf A 2.70 BS01 MGH A 1 H332 G335 H336 G339 E341 L359 V360 G361 Y609 H290 G293 H294 G297 E299 L317 V318 G319 Y567 3.4.24.56 P14735 NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gsf A 2.70 BS02 ZN A 1 H108 H112 E189 H66 H70 E147 3.4.24.56 P14735 NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gsf B 2.70 BS01 MGH B 1 H332 G339 E341 L359 V360 G361 Q363 H290 G297 E299 L317 V318 G319 Q321 3.4.24.56 P14735 NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gsf B 2.70 BS02 ZN B 1 H108 H112 E189 H66 H70 E147 3.4.24.56 P14735 NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH 4gt8 A 1.51 BS01 ADP A 1 E259 N263 T264 R266 H267 S268 D290 F295 K300 S304 G306 L307 T331 E51 N55 T56 R58 H59 S60 D82 F87 K92 S96 G98 L99 T123 2.7.13.3 Q7A2Q0 GAMLKDKSLGEGIKDLVIDLQKKVPMKVVHEIQDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGATFHIVSLPDSGTRIEVKAPLNK 4gt8 A 1.51 BS02 MG A 1 E259 N263 E51 N55 2.7.13.3 Q7A2Q0 GAMLKDKSLGEGIKDLVIDLQKKVPMKVVHEIQDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGATFHIVSLPDSGTRIEVKAPLNK 4hih A 2.00 BS01 RAM A 1 R91 N93 W94 R90 N92 W93 GQLTQSPATLSLSPGERATLSCRASQSVTNYLAWYQQKPGQAPRLLIYGASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRDNWPPDATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNR 4hih B 2.00 BS01 RAM A 1 G33 S52 E95 G33 S52 E99 LINLVESGGGVVQPGRSLRLSCAASGFTFSRYGMHWVRQAPGKGLEWVAVVSSDGRTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVFYCAKEGGDNKFSFDYWGQGTLVTVSSASTKGPSVFPLATAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVQTYTCNVDHKPSNTKVDKTVE 4hih C 2.00 BS01 RAM D 1 R91 N93 W94 P95A R86 N88 W89 P91 GQLTQSPATLSLSPGERATLSCRATNYLAWYQQKPGQAPRLLIYGASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRDNWPPDATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNR 4hih D 2.00 BS01 RAM D 1 G33 S52 E95 K100 G33 S52 E99 K104 LINLVESGGGVVQPGRSLRLSCAASGFTFSRYGMHWVRQAPGKGLEWVAVVSSDGRTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVFYCAKEGGDNKFSFDYWGQGTLVTVSSASTKGPSVFPLATAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVQTYTCNVDHKPSNTKVDKTVE 4hii A 2.30 BS01 GAL A 1 N93 W94 N92 W93 GQLTQSPATLSLSPGERATLSCRASQSVTNYLAWYQQKPGQAPRLLIYGASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRDNWPPDATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNR 4hii A 2.30 BS02 RAM A 1 R91 N93 P95A R90 N92 P95 GQLTQSPATLSLSPGERATLSCRASQSVTNYLAWYQQKPGQAPRLLIYGASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRDNWPPDATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNR 4hii B 2.30 BS01 RAM A 1 G33 V50 S52 E95 G33 V50 S52 E99 LINLVESGGGVVQPGRSLRLSCAASGFTFSRYGMHWVRQAPGKGLEWVAVVSSDGRTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVFYCAKEGGDNKFSFDYWGQGTLVTVSSASTKGPSVFPLATAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPQTYTCNVDHKPSNTKVDKTV 4hii C 2.30 BS01 RAM C 1 R91 N93 W94 R83 N85 W86 GQLTQSPATLSLSPGERATLSCRAYLAWYQQKPGQAPRLLIYGASNRATGIPARFSGSGGTDFTLTISSLEPEDFAVYYCQQRDNWPPDATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNR 4hii D 2.30 BS01 RAM C 1 S52 E95 K100 S52 E99 K104 LINLVESGGGVVQPGRSLRLSCAASGFTFSRYGMHWVRQAPGKGLEWVAVVSSDGRTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVFYCAKEGGDNKFSFDYWGQGTLVTVSSASTKGPSVFPLATAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPQTYTCNVDHKPSNTKVDKTV 4hij A 2.10 BS01 RAM B 1 R91 N93 R87 N89 TQSPATLSLSPGERATLSCRASQSVTNYLAWYQQKPGQAPRLLIYGASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRDNWPPDATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNR 4hij B 2.10 BS01 RAM B 1 S52 E95 K100 S51 E98 K103 INLVESGGGVVQPGRSLRLSCAASGFTFSRYGMHWVRQAPGKGLEWVAVVSSDGRTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVFYCAKEGGDNKFSFDYWGQGTLVTVSSASTKGPSVFPLASTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPQTYTCNVDHKPSNTKVDKTV 4hij B 2.10 BS02 GOL B 1 G33 S52A E95 G32 S52 E98 INLVESGGGVVQPGRSLRLSCAASGFTFSRYGMHWVRQAPGKGLEWVAVVSSDGRTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVFYCAKEGGDNKFSFDYWGQGTLVTVSSASTKGPSVFPLASTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPQTYTCNVDHKPSNTKVDKTV 4hij C 2.10 BS01 RAM D 1 R91 N93 P95A R90 N92 P95 GQLTQSPATLSLSPGERATLSCRASQSVTNYLAWYQQKPGQAPRLLIYGASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRDNWPPDATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNR 4hij D 2.10 BS01 RAM D 1 G33 S52 E95 G32 S51 E98 INLVESGGGVVQPGRSLRLSCAASGFTFSRYGMHWVRQAPGKGLEWVAVVSSDGRTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVFYCAKEGGDNKFSFDYWGQGTLVTVSSASTKGPSVFPLATAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPQTYTCNVDHKPSNTKVDKTV 4htx A 1.90 BS01 ZN A 1 H660 H696 D697 D808 H82 H118 D119 D230 3.1.4.17 O00408 23899287 DDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL 4htx A 1.90 BS02 19F A 1 Y655 H656 T768 L770 H773 L809 Q812 I826 Y827 F830 M847 L858 Q859 S861 F862 I866 I870 Y77 H78 T190 L192 H195 L231 Q234 I248 Y249 F252 M269 L280 Q281 S283 F284 I288 I292 3.1.4.17 O00408 23899287 DDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL 4htx B 1.90 BS01 ZN B 1 H660 H696 D697 D808 H81 H117 D118 D229 3.1.4.17 O00408 23899287 DEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDF 4htx B 1.90 BS02 19F B 1 Y655 H656 T768 L770 H773 T805 L809 Q812 I826 Y827 F830 M847 L858 Q859 S861 F862 I866 I870 Y76 H77 T189 L191 H194 T226 L230 Q233 I247 Y248 F251 M268 L279 Q280 S282 F283 I287 I291 3.1.4.17 O00408 23899287 DEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDF 4htx C 1.90 BS01 ZN C 1 H660 H696 D697 D808 H70 H106 D107 D218 3.1.4.17 O00408 23899287 QPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDF 4htx C 1.90 BS02 19F C 1 Y655 H656 L770 H773 L809 Q812 I826 Y827 F830 M847 L858 Q859 S861 F862 I866 I870 Y65 H66 L180 H183 L219 Q222 I236 Y237 F240 M257 L268 Q269 S271 F272 I276 I280 3.1.4.17 O00408 23899287 QPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDF 4htx D 1.90 BS01 ZN D 1 H660 H696 D697 D808 H71 H107 D108 D219 3.1.4.17 O00408 23899287 IQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL 4htx D 1.90 BS02 19F D 1 Y655 H656 T768 L770 H773 T805 L809 Q812 I826 Y827 F830 M847 L858 Q859 S861 F862 I866 I870 Y66 H67 T179 L181 H184 T216 L220 Q223 I237 Y238 F241 M258 L269 Q270 S272 F273 I277 I281 3.1.4.17 O00408 23899287 IQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL 4htz A 2.00 BS01 ZN A 1 H660 H696 D697 D808 H82 H118 D119 D230 3.1.4.17 O00408 23899287 DDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL 4htz B 2.00 BS01 ZN B 1 H660 H696 D697 D808 H81 H117 D118 D229 3.1.4.17 O00408 23899287 DEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL 4htz C 2.00 BS01 ZN C 1 H660 H696 D697 D808 H70 H106 D107 D218 3.1.4.17 O00408 23899287 QPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDF 4htz D 2.00 BS01 ZN D 1 H660 H696 D697 D808 H70 H106 D107 D218 3.1.4.17 O00408 23899287 QPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL 4i14 A 3.00 BS01 ZN A 1 C264 C275 C277 C252 C263 C265 4.1.99.12,3.5.4.25 A5U2B7 MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAYTVTVDARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHGLALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVALVRGEIAGDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAMVAREGRGVVLYMRYGIGAQILVDLGVRSMRLLTNNPDGYGLHIIERVPLP 4i14 B 3.00 BS01 ZN B 1 C264 C275 C277 C247 C258 C260 4.1.99.12,3.5.4.25 A5U2B7 MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYTVTVDARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHGLALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVALVRGEIGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAMVAREGRGVVLYMRYGIGAQILVDLGVRSMRLLTNNPADGYGLHIIERVPL 4i1r A 2.70 BS01 LZU A 1 V344 A345 L346 K379 V381 A394 E397 F398 L400 L401 R576 W580 L715 M717 V7 A8 L9 K42 V44 A57 E60 F61 L63 L64 R209 W213 L348 M350 3.4.22.- Q9UDY8 23946259 MLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKTANIVFGYATCQGASGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQSLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRH 4i3h A 3.70 BS01 NUC G 1 K458 V459 I460 N461 K464 H513 V626 R629 R1117 Y1118 I1170 S1171 A1172 G1173 A1175 K387 V388 I389 N390 K393 H442 V539 R542 R670 Y671 I723 S724 A725 G726 A728 5.99.1.-,5.99.1.3 D6ZLV0 AVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSDRIDVTINKDGSLTVQDHTVEVIFTILHAGGKFLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGAYAWDGELEELRLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTLENIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4i3h A 3.70 BS02 NUC H 1 G434 D435 S436 G457 R1028 K1038 V1040 H1074 H1076 G1077 S1080 R1087 K1093 T1168 I1170 E1262 G363 D364 S365 G386 R581 K591 V593 H627 H629 G630 S633 R640 K646 T721 I723 E815 5.99.1.-,5.99.1.3 D6ZLV0 AVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSDRIDVTINKDGSLTVQDHTVEVIFTILHAGGKFLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGAYAWDGELEELRLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTLENIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4i3h A 3.70 BS03 MG A 1 F1316 K1317 T1319 Q1322 F869 K870 T872 Q875 5.99.1.-,5.99.1.3 D6ZLV0 AVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSDRIDVTINKDGSLTVQDHTVEVIFTILHAGGKFLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGAYAWDGELEELRLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTLENIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4i3h B 3.70 BS01 NUC G 1 E433 G434 D435 S436 R456 G457 K458 D510 R1028 K1038 V1040 H1074 H1076 G1077 S1080 R1087 K1093 T1168 I1170 E366 G367 D368 S369 R389 G390 K391 D443 R579 K589 V591 H625 H627 G628 S631 R638 K644 T719 I721 5.99.1.-,5.99.1.3 D6ZLV0 EGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFDRIDVTINKDGSLTVQDHTVEVIFTILHAGGKFGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLNLEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARDESGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMAWTDGELEELLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTSNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4i3h B 3.70 BS02 NUC H 1 G457 K458 V459 I460 N461 K464 H513 L517 V626 R629 R630 R1117 Y1118 I1170 S1171 A1172 G1173 R1235 N1326 G390 K391 V392 I393 N394 K397 H446 L450 V538 R541 R542 R668 Y669 I721 S722 A723 G724 R786 N877 5.99.1.-,5.99.1.3 D6ZLV0 EGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFDRIDVTINKDGSLTVQDHTVEVIFTILHAGGKFGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLNLEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARDESGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMAWTDGELEELLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTSNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4i3h B 3.70 BS03 MG B 1 F1316 T1319 Q1322 F867 T870 Q873 5.99.1.-,5.99.1.3 D6ZLV0 EGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFDRIDVTINKDGSLTVQDHTVEVIFTILHAGGKFGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLNLEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARDESGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMAWTDGELEELLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTSNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED 4ifc A 2.13 BS01 ADP A 1 T693 V697 F698 S699 V701 A715 K717 L751 F767 E768 L770 N773 D819 L822 D834 T26 V30 F31 S32 V34 A48 K50 L84 F100 E101 L103 N106 D152 L155 D167 2.7.11.1 Q13523 WTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEREKVTVMSTINPTKDLLADLILPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 4ifc B 2.13 BS01 ADP B 1 T693 V697 F698 S699 V701 A715 K717 F767 E768 L770 N773 D819 L822 D834 T24 V27 F28 S29 V31 A45 K47 F97 E98 L100 N103 D149 L152 D164 2.7.11.1 Q13523 DAEGYYRVNIGEVLDKRYNVYGYTGQVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDEREKVTVMSTINPTKDLLADLIQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 4iir A 2.00 BS01 ANP A 1 T693 S699 V701 A715 K717 L751 F767 E768 L770 N773 D819 N820 L822 D834 T26 S30 V32 A46 K48 L82 F98 E99 L101 N104 D150 N151 L153 D165 2.7.11.1 Q13523 WTDAEGYYRVNIGEVLDKRYNVYGYTGQGSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEREKVTVMSTINPTKDLLADLILPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 4iir B 2.00 BS01 ANP B 1 T693 S699 V701 A715 K717 L751 F767 E768 L770 N773 D819 N820 L822 D834 T24 S27 V29 A43 K45 L79 F95 E96 L98 N101 D147 N148 L150 D162 2.7.11.1 Q13523 DAEGYYRVNIGEVLDKRYNVYGYTGQSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDEREKVTVMSTINPTKDLLADLIQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 4ijp A 2.25 BS01 1EH A 1 T693 V701 R703 A715 K717 L751 F767 E768 L770 S771 M772 E776 L822 T24 V32 R34 A46 K48 L82 F98 E99 L101 S102 M103 E107 L153 2.7.11.1 Q13523 DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDEREKVTVMSTINPTKDLLADLIQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 4ijp B 2.25 BS01 1EH B 1 T693 V701 R703 A715 K717 L751 L770 S771 M772 E776 L822 T26 V34 R36 A48 K50 L84 L103 S104 M105 E109 L155 2.7.11.1 Q13523 WTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 4irj A 3.00 BS01 FUC A 1 S114 F128 W129 G130 L164 N165 S108 F122 W123 G124 L158 N159 P11609 NYTFRCLQMSSFANRSWSRTDSVVWLGDLQTHRWSNDSATISFTKPWSQGKLSNQQWEKLQHMFQVYRVSFTRDIQELVKMMSPKEDYPIEIQLSAGCEMYPGNASESFLHVAFQGKYVVRFWGTSWQTVPGAPSWLDLPIKVLNADQGTSATVQMLLNDTCPLFVRGLLEAGKSDLEKQEKPVAWLSSVPRQLVCHVSGFYPKPVWVMWMRGDQEQQGTHRGDFLPNADETWYLQATLDVEAGEEAGLACRVKHSSLGGQDIILYW 4irj A 3.00 BS02 1L9 A 1 F10 C12 Q14 I47 L66 M69 Y73 S76 D80 L84 L100 V118 W133 L150 D153 G155 T156 T159 V160 M162 L163 C168 F171 F4 C6 Q8 I41 L60 M63 Y67 S70 D74 L78 L94 V112 W127 L144 D147 G149 T150 T153 V154 M156 L157 C162 F165 P11609 NYTFRCLQMSSFANRSWSRTDSVVWLGDLQTHRWSNDSATISFTKPWSQGKLSNQQWEKLQHMFQVYRVSFTRDIQELVKMMSPKEDYPIEIQLSAGCEMYPGNASESFLHVAFQGKYVVRFWGTSWQTVPGAPSWLDLPIKVLNADQGTSATVQMLLNDTCPLFVRGLLEAGKSDLEKQEKPVAWLSSVPRQLVCHVSGFYPKPVWVMWMRGDQEQQGTHRGDFLPNADETWYLQATLDVEAGEEAGLACRVKHSSLGGQDIILYW 4irj C 3.00 BS01 1L9 A 1 P29 N31 R95 G96 P28 N30 R94 G95 TQVEQSPQSLVVRQGENCVLQCNYSVTPDNHLRWFKQDTGKGLVSLTVLVDQKDKTSNGRYSATLDKDAKHSTLHITATLLDDTATYICVVGDRGSALGRLHFGAGTQLIVIPDIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKDFACANAFNNSIIPEDTFFPS 4j6i A 2.90 BS01 1JV A 1 W812 I831 K833 Y867 I879 E880 I881 V882 K883 D884 A885 M953 F961 I963 D964 W570 I589 K591 Y625 I637 E638 I639 V640 K641 D642 A643 M711 F719 I721 D722 2.7.1.153,2.7.11.1 P48736 23540645 MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEECDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCLLYYVNLLLIDHRFLLRRGEYVLHMWQISGFNADKLTSATNPDKENSMSISILLDNHPIAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHIERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWF 4jfi A 1.05 BS01 1KT A 1 Y57 F67 D68 R73 F77 Q85 V86 I87 W90 Y113 S118 K121 F130 Y45 F55 D56 R61 F65 Q73 V74 I75 W78 Y101 S106 K109 F118 5.2.1.8 Q13451 23647266 GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKG 4jfj A 1.08 BS01 1KU A 1 Y57 F67 D68 F77 G84 Q85 V86 I87 W90 A112 Y113 S118 I122 F130 Y45 F55 D56 F65 G72 Q73 V74 I75 W78 A100 Y101 S106 I110 F118 5.2.1.8 Q13451 23647266 GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGE 4jfk A 1.15 BS01 JFK A 1 Y57 F67 D68 F77 G84 Q85 V86 I87 W90 A112 Y113 S118 L119 P120 K121 I122 F130 Y45 F55 D56 F65 G72 Q73 V74 I75 W78 A100 Y101 S106 L107 P108 K109 I110 F118 5.2.1.8 Q13451 23647266 GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGE 4jfl A 1.20 BS01 1KY A 1 Y57 F67 D68 F77 G84 Q85 V86 I87 W90 Y113 I122 F130 Y45 F55 D56 F65 G72 Q73 V74 I75 W78 Y101 I110 F118 5.2.1.8 Q13451 23647266 GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGE 4jfm A 1.02 BS01 1KZ A 1 Y57 F67 D68 R73 F77 V86 I87 W90 Y113 F130 Y45 F55 D56 R61 F65 V74 I75 W78 Y101 F118 5.2.1.8 Q13451 23647266 GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGE 4jfz L 1.75 BS01 III P 1 S91 F92 N93 V94 S91 F92 N93 V94 23955275 DIVLTQSPATLSLSPGERATLSCMTSTDIDDDMNWYQQKPGQAPRLLISEGNTLRPGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCLQSFNVPLTFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 4jfz H 1.75 BS01 III P 1 G33 A52 T52A G53 G54 H55 T56 Y58 S97 S98 T99 S100 Y100A G33 A52 T53 G54 G55 H56 T57 Y59 S101 S102 T103 S104 Y105 23955275 EVQLVESGGGLVQPGGSLRLSCVTSGFTFRKFGMSWVRQAPGKGLEWVASIATGGHTTYYSDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGYSSTSYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC 4jg0 L 1.81 BS01 III P 1 S91 F92 N93 V94 S91 F92 N93 V94 23955275 DIVLTQSPATLSLSPGERATLSCMTSTDIDDDMNWYQQKPGQAPRLLISEGNTLRPGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCLQSFNVPLTFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 4jg0 H 1.81 BS01 III P 1 G33 S52 T52A P52B R53 G54 S55 Y58 S97 S98 T99 S100 Y100A G33 S52 T53 P54 R55 G56 S57 Y60 S102 S103 T104 S105 Y106 23955275 EVQLVESGGGLVQPGGSLRLSCVTSGFTFRKFGMSWVRQAPGKGLEWVASISTPRGSTTYYSDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGYSSTSYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC 4jg1 L 1.55 BS01 III P 1 S91 F92 N93 V94 S91 F92 N93 V94 23955275 DIVLTQSPATLSLSPGERATLSCMTSTDIDDDMNWYQQKPGQAPRLLISEGNTLRPGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCLQSFNVPLTFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 4jg1 H 1.55 BS01 III P 1 G33 S52 T52A P52B R53 G54 S55 T56 Y58 S97 S98 T99 S100 Y100A G34 S53 T54 P55 R56 G57 S58 T59 Y61 S103 S104 T105 S106 Y107 23955275 SEVQLVESGGGLVQPGGSLRLSCVTSGFTFRKFGMSWVRQAPGKGLEWVASISTPRGSTTYYSDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGYSSTSYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC 4jhz A 2.83 BS01 1KV A 1 D163 L361 E413 V446 M447 Y468 Y472 V473 R562 D165 L363 E408 V441 M442 Y463 Y467 V468 R557 3.2.1.31 P05804 23690068 SHMLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQGG 4jhz B 2.83 BS01 1KV B 1 D163 L361 E413 V446 M447 Y468 Y472 R562 D165 L363 E408 V441 M442 Y463 Y467 R557 3.2.1.31 P05804 23690068 SHMLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQGG 4jny A 1.90 BS01 FAD A 1 A370 A371 V402 Q404 Y406 R431 V433 K434 G435 A436 Y437 W438 Y456 T457 R458 K459 T462 A485 T486 H487 N488 Q511 C512 L513 Y540 R556 E559 S565 F566 A251 A252 V283 Q285 Y287 R312 V314 K315 G316 A317 Y318 W319 Y337 T338 R339 K340 T343 A366 T367 H368 N369 Q392 C393 L394 Y421 R437 E440 S446 F447 1.5.99.8,1.5.1.12 P09546 23713611 PQSVSRAAITAAYRRPETEAVSMLLEQARLPQPVAEQAHKLAYQLADKLRNQKNASGRAGMVQGLLQEFSLSSQEGVALMCLAEALLRIPDKATRDALLFVNAATWGLLFASLSRSLNRIIEPLIRKGVDMAMRLMGEQFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTAADAQAYMVSYQQAIHAIGKASNGRGIYEGPGISIKLSALHPRYSRAQYDRVMEELYPRLKSLTLLARQYDIGINIAAEESDRLEISLDLLEKLCFEPELAGWNGIGFVIQAYQKRCPLVIDYLIDLATRSRRRLMIRLVKGAYWDSEIKRAQMDGLEGYPVYTRKVYTDVSYLACAKKLLAVPNLIYPQFATHNAHTLAAIYQLAGQNYYPGQYEFQCLHGMGEPLYEQVTGKVADGKLNRPCRIYAPVGTHETLLAYLVRRLLENGANTSFVNRIADTSLPLDELVADPVTAVEKLAQQEGQTGLPHPKIPLPRD 4jny A 1.90 BS02 TFB A 1 K329 A436 Y540 Y552 R555 R556 K210 A317 Y421 Y433 R436 R437 1.5.99.8,1.5.1.12 P09546 23713611 PQSVSRAAITAAYRRPETEAVSMLLEQARLPQPVAEQAHKLAYQLADKLRNQKNASGRAGMVQGLLQEFSLSSQEGVALMCLAEALLRIPDKATRDALLFVNAATWGLLFASLSRSLNRIIEPLIRKGVDMAMRLMGEQFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTAADAQAYMVSYQQAIHAIGKASNGRGIYEGPGISIKLSALHPRYSRAQYDRVMEELYPRLKSLTLLARQYDIGINIAAEESDRLEISLDLLEKLCFEPELAGWNGIGFVIQAYQKRCPLVIDYLIDLATRSRRRLMIRLVKGAYWDSEIKRAQMDGLEGYPVYTRKVYTDVSYLACAKKLLAVPNLIYPQFATHNAHTLAAIYQLAGQNYYPGQYEFQCLHGMGEPLYEQVTGKVADGKLNRPCRIYAPVGTHETLLAYLVRRLLENGANTSFVNRIADTSLPLDELVADPVTAVEKLAQQEGQTGLPHPKIPLPRD 4jnz A 1.85 BS01 FAD A 1 N370 A371 V402 Q404 Y406 R431 V433 K434 G435 A436 Y437 W438 Y456 T457 R458 K459 T462 A485 T486 H487 N488 Q511 C512 L513 Y540 R556 E559 S565 F566 N253 A254 V285 Q287 Y289 R314 V316 K317 G318 A319 Y320 W321 Y339 T340 R341 K342 T345 A368 T369 H370 N371 Q394 C395 L396 Y423 R439 E442 S448 F449 1.5.99.8,1.5.1.12 P09546 23713611 PQSVSRAAITAAYRRPETEAVSMLLEQARLPQPVAEQAHKLAYQLADKLRNQKNASGRAGMVQGLLQEFSLSSQEGVALMCLAEALLRIPDKATRDALIRDLFVNAATWGLLFASLSRSLNRIIPLIRKGVDMAMRLMGEQFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTAADAQAYMVSYQQAIHAIGKASNGRGIYEGPGISIKLSALHPRYSRAQYDRVMEELYPRLKSLTLLARQYDIGININAEESDRLEISLDLLEKLCFEPELAGWNGIGFVIQAYQKRCPLVIDYLIDLATRSRRRLMIRLVKGAYWDSEIKRAQMDGLEGYPVYTRKVYTDVSYLACAKKLLAVPNLIYPQFATHNAHTLAAIYQLAGQNYYPGQYEFQCLHGMGEPLYEQVTGKVADGKLNRPCRIYAPVGTHETLLAYLVRRLLENGANTSFVNRIADTSLPLDELVADPVTAVEKLAQQEGQTGLPHPKIPLPRD 4jnz A 1.85 BS02 TFB A 1 N370 A436 Y540 Y552 R555 R556 N253 A319 Y423 Y435 R438 R439 1.5.99.8,1.5.1.12 P09546 23713611 PQSVSRAAITAAYRRPETEAVSMLLEQARLPQPVAEQAHKLAYQLADKLRNQKNASGRAGMVQGLLQEFSLSSQEGVALMCLAEALLRIPDKATRDALIRDLFVNAATWGLLFASLSRSLNRIIPLIRKGVDMAMRLMGEQFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTAADAQAYMVSYQQAIHAIGKASNGRGIYEGPGISIKLSALHPRYSRAQYDRVMEELYPRLKSLTLLARQYDIGININAEESDRLEISLDLLEKLCFEPELAGWNGIGFVIQAYQKRCPLVIDYLIDLATRSRRRLMIRLVKGAYWDSEIKRAQMDGLEGYPVYTRKVYTDVSYLACAKKLLAVPNLIYPQFATHNAHTLAAIYQLAGQNYYPGQYEFQCLHGMGEPLYEQVTGKVADGKLNRPCRIYAPVGTHETLLAYLVRRLLENGANTSFVNRIADTSLPLDELVADPVTAVEKLAQQEGQTGLPHPKIPLPRD 4jst A 2.03 BS01 UTP A 1 S17 G18 S19 G20 K21 S22 T23 R116 R120 R123 S18 G19 S20 G21 K22 S23 T24 R117 R121 R124 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQP 4jst B 2.03 BS01 UTP B 1 S16 S17 G18 S19 G20 K21 S22 T23 R116 R120 S17 S18 G19 S20 G21 K22 S23 T24 R117 R121 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQP 4jst B 2.03 BS02 NA B 1 T23 F24 K27 V161 T24 F25 K28 V162 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQP 4jsy A 2.14 BS01 GTP A 1 S17 G18 S19 G20 K21 S22 T23 R116 R120 R123 E162 S18 G19 S20 G21 K22 S23 T24 R117 R121 R124 E163 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQP 4jsy A 2.14 BS02 MG A 1 S22 R123 S23 R124 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQP 4jsy B 2.14 BS01 GTP B 1 S17 G18 S19 G20 K21 S22 T23 R116 R120 S18 G19 S20 G21 K22 S23 T24 R117 R121 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQP 4jt2 A 2.49 BS01 MG A 1 S22 R123 S23 R124 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQP 4jt2 A 2.49 BS02 CTP A 1 S16 S17 G18 S19 G20 K21 S22 T23 R116 R120 R123 S17 S18 G19 S20 G21 K22 S23 T24 R117 R121 R124 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQP 4jt2 B 2.49 BS01 CTP B 1 S17 G18 G20 K21 S22 T23 R116 R120 R123 S18 G19 G21 K22 S23 T24 R117 R121 R124 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQ 4jt2 B 2.49 BS02 MG B 1 S22 R123 S23 R124 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQ 4jt4 A 2.01 BS01 DTP A 1 S16 S17 G18 S19 G20 K21 S22 T23 R116 R120 R123 S17 S18 G19 S20 G21 K22 S23 T24 R117 R121 R124 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQP 4jt4 B 2.01 BS01 DTP B 1 S17 G18 S19 G20 K21 S22 T23 R116 R120 S18 G19 S20 G21 K22 S23 T24 R117 R121 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQP 4jt4 B 2.01 BS02 NA B 1 T23 F24 K27 V161 T24 F25 K28 V162 2.7.1.78 A3DJ38 23721485 SMKLTIPELSLVVLIGSSGSGKSTFAKKHFKPTEVISSDFCRGLMSDDENDQTVTGAAFDVLHYIVSKRLQLGKLTVVDATNVQESARKPLIEIAKDYHCFPVAVVFNLPEKVCQERNKNRTDRQVEEYVIRKHTQQMKKSIKGLQREGFRYVYILNSPEEVEEVVFERQP 4juo A 6.53 BS01 NUC E 1 R28 K38 V40 H74 H76 G77 S80 A84 R87 K93 T168 I170 R26 K36 V38 H72 H74 G75 S78 A82 R85 K91 T166 I168 5.99.1.3 P72525 NIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFTPRLSSLED 4juo A 6.53 BS02 NUC F 1 R117 Y118 I170 S171 G173 Y174 A175 N326 N328 R115 Y116 I168 S169 G171 Y172 A173 N324 N326 5.99.1.3 P72525 NIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFTPRLSSLED 4juo A 6.53 BS03 NUC G 1 R28 K38 H74 R87 T168 R26 K36 H72 R85 T166 5.99.1.3 P72525 NIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFTPRLSSLED 4juo A 6.53 BS04 NUC H 1 R117 Y118 I170 G173 N326 R115 Y116 I168 G171 N324 5.99.1.3 P72525 NIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFTPRLSSLED 4juo C 6.53 BS01 NUC E 1 E433 G457 E358 G382 5.99.1.3 Q59961 AVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSDRIDVTINKDGSLTVQDHTVEVIFTILHAGGKFLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYEVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIAPPLYKAYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFT 4juo C 6.53 BS02 NUC F 1 N461 K464 N473 H513 V626 R630 N386 K389 N398 H438 V532 R536 5.99.1.3 Q59961 AVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSDRIDVTINKDGSLTVQDHTVEVIFTILHAGGKFLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYEVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIAPPLYKAYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFT 4juo C 6.53 BS03 NUC G 1 E433 G457 K458 E358 G382 K383 5.99.1.3 Q59961 AVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSDRIDVTINKDGSLTVQDHTVEVIFTILHAGGKFLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYEVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIAPPLYKAYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFT 4juo C 6.53 BS04 NUC H 1 I460 N461 K464 V626 R629 I385 N386 K389 V532 R535 5.99.1.3 Q59961 AVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSDRIDVTINKDGSLTVQDHTVEVIFTILHAGGKFLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYEVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIAPPLYKAYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFT 4juo C 6.53 BS05 MG C 1 D506 D508 D431 D433 5.99.1.3 Q59961 AVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSDRIDVTINKDGSLTVQDHTVEVIFTILHAGGKFLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYEVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIAPPLYKAYAWTDGELEELRKLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFT 4juz A 2.65 BS01 NUC B 1 Y12 V32 S34 A42 K78 G218 E219 A220 R242 K243 S244 I245 G246 R247 I248 T250 R331 R332 R336 Y12 V32 S34 A42 K78 G218 E219 A220 R242 K243 S244 I245 G246 R247 I248 T250 R331 R332 R336 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4juz A 2.65 BS02 NUC C 1 S103 D105 E106 K152 G185 I186 G187 I189 T190 K193 V296 S297 R298 G299 T301 K339 S103 D105 E106 K152 G185 I186 G187 I189 T190 K193 V296 S297 R298 G299 T301 K339 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4juz A 2.65 BS03 DGT A 1 D9 Y10 F11 Y12 A44 T45 Y48 R51 D105 K159 D9 Y10 F11 Y12 A44 T45 Y48 R51 D105 K159 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4juz A 2.65 BS04 CA A 1 D7 F8 F11 D105 D7 F8 F11 D105 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4juz A 2.65 BS05 CA A 2 A181 D182 A181 D182 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv0 A 2.95 BS01 NUC B 1 Y12 V32 G41 A42 K78 G218 E219 A220 R238 R242 K243 S244 I245 G246 R247 I248 T250 K275 R331 R332 R336 Y12 V32 G41 A42 K78 G218 E219 A220 R238 R242 K243 S244 I245 G246 R247 I248 T250 K275 R331 R332 R336 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv0 A 2.95 BS02 NUC C 1 S103 D105 E106 K152 P184 G185 G187 I189 T190 K193 V296 S297 R298 G299 R300 T301 K321 K339 S103 D105 E106 K152 P184 G185 G187 I189 T190 K193 V296 S297 R298 G299 R300 T301 K321 K339 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv0 A 2.95 BS03 DTP A 1 F8 D9 Y10 F11 Y12 A44 T45 Y48 R51 D105 K159 F8 D9 Y10 F11 Y12 A44 T45 Y48 R51 D105 K159 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv0 A 2.95 BS04 CA A 1 D7 F8 D9 D105 D7 F8 D9 D105 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv0 A 2.95 BS05 CA A 2 A181 I186 G187 A181 I186 G187 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv1 A 2.30 BS01 NUC B 1 V32 S34 G58 G218 E219 A220 R238 R242 K243 S244 I245 G246 R247 I248 T250 R331 R332 R336 V32 S34 G58 G218 E219 A220 R238 R242 K243 S244 I245 G246 R247 I248 T250 R331 R332 R336 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv1 A 2.30 BS02 NUC C 1 E106 P184 G185 G187 I189 T190 K193 S297 R298 G299 R300 T301 K339 E106 P184 G185 G187 I189 T190 K193 S297 R298 G299 R300 T301 K339 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv1 A 2.30 BS03 DGT A 1 Y10 F11 Y12 A44 T45 Y48 R51 D105 K159 Y10 F11 Y12 A44 T45 Y48 R51 D105 K159 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv1 A 2.30 BS04 CA A 1 D7 F8 D105 D7 F8 D105 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv1 A 2.30 BS05 CA A 2 D7 D105 E106 D7 D105 E106 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv1 A 2.30 BS06 CA A 3 A181 I186 A181 I186 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv2 A 2.74 BS01 NUC B 1 V32 A42 G58 G218 E219 A220 R238 R242 K243 S244 I245 G246 R247 I248 T250 R331 R332 R336 V32 A42 G58 G218 E219 A220 R238 R242 K243 S244 I245 G246 R247 I248 T250 R331 R332 R336 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv2 A 2.74 BS02 NUC C 1 K152 P184 G185 I186 G187 I189 T190 K193 V296 S297 R298 G299 R300 T301 K321 K339 K152 P184 G185 I186 G187 I189 T190 K193 V296 S297 R298 G299 R300 T301 K321 K339 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv2 A 2.74 BS03 DTP A 1 D7 F8 D9 Y10 F11 Y12 A44 T45 Y48 R51 A57 D105 K159 D7 F8 D9 Y10 F11 Y12 A44 T45 Y48 R51 A57 D105 K159 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv2 A 2.74 BS04 CA A 1 D7 F8 D9 D105 D7 F8 D9 D105 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jv2 A 2.74 BS05 CA A 2 A181 I186 A181 I186 2.7.7.7 Q97W02 23947567 MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI 4jx7 A 2.40 BS01 III B 1 D128 F130 D131 I133 T134 K169 D170 E171 T204 V206 D234 G238 D239 I240 E243 D96 F98 D99 I101 T102 K137 D138 E139 T172 V174 D202 G206 D207 I208 E211 2.7.11.1 P11309 23936194 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHS 4jx7 A 2.40 BS02 1N6 A 1 L44 G45 A65 E121 R122 P123 V126 D128 L174 L12 G13 A33 E89 R90 P91 V94 D96 L142 2.7.11.1 P11309 23936194 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHS 4k6b A 1.10 BS01 GLU A 1 E181 K235 K312 I314 E18 K72 K149 I151 23951045 GSSRISALEYATTRKKSEVVYSGVSVTIPTAPTNLVSLLKTLTPSSGTLAPFFDTVNNKMVVFNENKTLFFKLSIVGTWPSGTANRSMQLTFSGSVPDTLVSSRNSATTTDNILLATFFSVDKDGFLATNGSTLTIQSNGAAFTATTIKIIAEQ 4k6b A 1.10 BS02 GLU B 1 F282 S283 V284 D285 F289 L290 F119 S120 V121 D122 F126 L127 23951045 GSSRISALEYATTRKKSEVVYSGVSVTIPTAPTNLVSLLKTLTPSSGTLAPFFDTVNNKMVVFNENKTLFFKLSIVGTWPSGTANRSMQLTFSGSVPDTLVSSRNSATTTDNILLATFFSVDKDGFLATNGSTLTIQSNGAAFTATTIKIIAEQ 4k6b B 1.10 BS01 GLU B 1 E181 K235 K312 I314 E20 K74 K151 I153 23951045 EFGSSRISALEYATTRKKSEVVYSGVSVTIPTAPTNLVSLLKTLTPSSGTLAPFFDTVNNKMVVFNENKTLFFKLSIVGTWPSGTANRSMQLTFSGSVPDTLVSSRNSATTTDNILLATFFSVDKDGFLATNGSTLTIQSNGAAFTATTIKIIAEQ 4k6b B 1.10 BS02 GLU C 1 F282 S283 D285 F289 L290 F121 S122 D124 F128 L129 23951045 EFGSSRISALEYATTRKKSEVVYSGVSVTIPTAPTNLVSLLKTLTPSSGTLAPFFDTVNNKMVVFNENKTLFFKLSIVGTWPSGTANRSMQLTFSGSVPDTLVSSRNSATTTDNILLATFFSVDKDGFLATNGSTLTIQSNGAAFTATTIKIIAEQ 4k6b C 1.10 BS01 GLU A 1 F282 S283 V284 D285 F289 L290 F118 S119 V120 D121 F125 L126 23951045 SSRISALEYATTRKKSEVVYSGVSVTIPTAPTNLVSLLKTLTPSSGTLAPFFDTVNNKMVVFNENKTLFFKLSIVGTWPSGTANRSMQLTFSGSVPDTLVSSRNSATTTDNILLATFFSVDKDGFLATNGSTLTIQSNGAAFTATTIKIIAEQ 4k6b C 1.10 BS02 GLU C 1 E181 K235 K312 I314 E17 K71 K148 I150 23951045 SSRISALEYATTRKKSEVVYSGVSVTIPTAPTNLVSLLKTLTPSSGTLAPFFDTVNNKMVVFNENKTLFFKLSIVGTWPSGTANRSMQLTFSGSVPDTLVSSRNSATTTDNILLATFFSVDKDGFLATNGSTLTIQSNGAAFTATTIKIIAEQ 4k6m A 2.60 BS01 SAH A 1 S56 G58 G81 C82 G86 W87 T104 K105 H110 V130 D131 V132 F133 D146 S52 G54 G77 C78 G82 W83 T100 K101 H106 V126 D127 V128 F129 D142 Q5NT71 GRTLGEQWKEKLNAMSREEFFKYRREAIIEVDRTEARRARRENNIVGGHPVSRGSAKLRWLVEKGFVSPIGKVIDLGCGRGGWSYYAATLKKVQEVRGYTKGGAGHEEPMLMQSYGWNLVSLKSGVDVFYKPSEPSDTLFCDIGESSPSPEVEEQRTLRVLEMTSDWLHRGPREFCIKVLCPYMPKVIEKMEVLQRRFGGGLVRLPLSRNSNHEMYWVSGAAGNVVHAVNMTSQVLLGRMDRTVWRGPKYEEDVNLGSGTRAVGKGSNQEKIKKRIQKLKEEFATTWHKDPEHPYRTWTYHGSYEVKATGSASSLVNGVVKLMSKPWDAIANVTTMAMTDTTPFGQQRVFKEKVDTKAPEPPAGAKEVLNETTNWLWAYLSREKRPRLCTKEEFIKKVNSNAALGAVFAEQNQWSTAREAVDDPRFWEMVDEERENHLRGECHTCIYNMMGKREKKPGEFGKAKGSRAIWFMWLGARYLEFEALGFLNEDHWLSRENSGGGVEGSGVQKLGYILRDIAGKQGGKMYADDTAGWDTRITRTDLENEAKVLELLDGEHRMLARAIIELTYRHKVVKVMRPAAEGKTVMDVISREDQRGSGQVVTYALNTFTNIAVQLVRLMEAEGVIGPQHLEQLPRKNKIAVRTWLFENGEERVTRMAISGDDCVVKPLDDRFATALHFLNAMSKVRKDIQEWKPSHGWHDWQQVPFCSNHFQEIVMKDGRSIVVPCRGQDELIGRARISPGAGWNVKDTACLAKAYAQMWLLLYFHRRDLRLMANAICSAVPVDWVPTGRTSWSIHSKGEWMTTEDMLQVWNRVWIEENEWMMDKTPITSWTDVPYVGKREDIWCGSLIGTRSRATWAENIYAAINQVRAVIGKENYVDYMTSLRRYE 4k6m A 2.60 BS02 ZN A 1 E440 H444 C449 C452 E433 H437 C442 C445 Q5NT71 GRTLGEQWKEKLNAMSREEFFKYRREAIIEVDRTEARRARRENNIVGGHPVSRGSAKLRWLVEKGFVSPIGKVIDLGCGRGGWSYYAATLKKVQEVRGYTKGGAGHEEPMLMQSYGWNLVSLKSGVDVFYKPSEPSDTLFCDIGESSPSPEVEEQRTLRVLEMTSDWLHRGPREFCIKVLCPYMPKVIEKMEVLQRRFGGGLVRLPLSRNSNHEMYWVSGAAGNVVHAVNMTSQVLLGRMDRTVWRGPKYEEDVNLGSGTRAVGKGSNQEKIKKRIQKLKEEFATTWHKDPEHPYRTWTYHGSYEVKATGSASSLVNGVVKLMSKPWDAIANVTTMAMTDTTPFGQQRVFKEKVDTKAPEPPAGAKEVLNETTNWLWAYLSREKRPRLCTKEEFIKKVNSNAALGAVFAEQNQWSTAREAVDDPRFWEMVDEERENHLRGECHTCIYNMMGKREKKPGEFGKAKGSRAIWFMWLGARYLEFEALGFLNEDHWLSRENSGGGVEGSGVQKLGYILRDIAGKQGGKMYADDTAGWDTRITRTDLENEAKVLELLDGEHRMLARAIIELTYRHKVVKVMRPAAEGKTVMDVISREDQRGSGQVVTYALNTFTNIAVQLVRLMEAEGVIGPQHLEQLPRKNKIAVRTWLFENGEERVTRMAISGDDCVVKPLDDRFATALHFLNAMSKVRKDIQEWKPSHGWHDWQQVPFCSNHFQEIVMKDGRSIVVPCRGQDELIGRARISPGAGWNVKDTACLAKAYAQMWLLLYFHRRDLRLMANAICSAVPVDWVPTGRTSWSIHSKGEWMTTEDMLQVWNRVWIEENEWMMDKTPITSWTDVPYVGKREDIWCGSLIGTRSRATWAENIYAAINQVRAVIGKENYVDYMTSLRRYE 4k6m A 2.60 BS03 ZN A 2 H717 C733 E848 C852 H710 C726 E841 C845 Q5NT71 GRTLGEQWKEKLNAMSREEFFKYRREAIIEVDRTEARRARRENNIVGGHPVSRGSAKLRWLVEKGFVSPIGKVIDLGCGRGGWSYYAATLKKVQEVRGYTKGGAGHEEPMLMQSYGWNLVSLKSGVDVFYKPSEPSDTLFCDIGESSPSPEVEEQRTLRVLEMTSDWLHRGPREFCIKVLCPYMPKVIEKMEVLQRRFGGGLVRLPLSRNSNHEMYWVSGAAGNVVHAVNMTSQVLLGRMDRTVWRGPKYEEDVNLGSGTRAVGKGSNQEKIKKRIQKLKEEFATTWHKDPEHPYRTWTYHGSYEVKATGSASSLVNGVVKLMSKPWDAIANVTTMAMTDTTPFGQQRVFKEKVDTKAPEPPAGAKEVLNETTNWLWAYLSREKRPRLCTKEEFIKKVNSNAALGAVFAEQNQWSTAREAVDDPRFWEMVDEERENHLRGECHTCIYNMMGKREKKPGEFGKAKGSRAIWFMWLGARYLEFEALGFLNEDHWLSRENSGGGVEGSGVQKLGYILRDIAGKQGGKMYADDTAGWDTRITRTDLENEAKVLELLDGEHRMLARAIIELTYRHKVVKVMRPAAEGKTVMDVISREDQRGSGQVVTYALNTFTNIAVQLVRLMEAEGVIGPQHLEQLPRKNKIAVRTWLFENGEERVTRMAISGDDCVVKPLDDRFATALHFLNAMSKVRKDIQEWKPSHGWHDWQQVPFCSNHFQEIVMKDGRSIVVPCRGQDELIGRARISPGAGWNVKDTACLAKAYAQMWLLLYFHRRDLRLMANAICSAVPVDWVPTGRTSWSIHSKGEWMTTEDMLQVWNRVWIEENEWMMDKTPITSWTDVPYVGKREDIWCGSLIGTRSRATWAENIYAAINQVRAVIGKENYVDYMTSLRRYE 4k6m B 2.60 BS01 SAH B 1 S56 G58 G81 C82 G86 W87 T104 K105 H110 V130 D131 V132 F133 D146 I147 S52 G54 G77 C78 G82 W83 T100 K101 H106 V126 D127 V128 F129 D142 I143 Q5NT71 GRTLGEQWKEKLNAMSREEFFKYRREAIIEVDRTEARRARRENNIVGGHPVSRGSAKLRWLVEKGFVSPIGKVIDLGCGRGGWSYYAATLKKVQEVRGYTKGGAGHEEPMLMQSYGWNLVSLKSGVDVFYKPSEPSDTLFCDIGESSPSPEVEEQRTLRVLEMTSDWLHRGPREFCIKVLCPYMPKVIEKMEVLQRRFGGGLVRLPLSRNSNHEMYWVSGAAGNVVHAVNMTSQVLLGRMDRTVWRGPKYEEDVNLGSGTRAVGKGSNQEKIKKRIQKLKEEFATTWHKDPEHPYRTWTYHGSYEVKATGSASSLVNGVVKLMSKPWDAIANVTTMAMTDTTPFGQQRVFKEKVDTKAPEPPAGAKEVLNETTNWLWAYLSREKRPRLCTKEEFIKKVNSNAALGAVFAEQNQWSTAREAVDDPRFWEMVDEERENHLRGECHTCIYNMMGKREKKPGEFGKAKGSRAIWFMWLGARYLEFEALGFLNEDHWLSRENSGGGVEGSGVQKLGYILRDIAGKQGGKMYADDTAGWDTRITRTDLENEAKVLELLDGEHRMLARAIIELTYRHKVVKVMRPAAEGKTVMDVISREDQRGSGQVVTYALNTFTNIAVQLVRLMEAEGVIGPQHLEQLPRKNKIAVRTWLFENGEERVTRMAISGDDCVVKPLDDRFATALHFLNAMSKVRKDIQEWKPSHGWHDWQQVPFCSNHFQEIVMKDGRSIVVPCRGQDELIGRARISPGAGWNVKDTACLAKAYAQMWLLLYFHRRDLRLMANAICSAVPVDWVPTGRTSWSIHSKGEWMTTEDMLQVWNRVWIEENEWMMDKTPITSWTDVPYVGKREDIWCGSLIGTRSRATWAENIYAAINQVRAVIGKENYVDYMTSLRRYE 4k6m B 2.60 BS02 ZN B 1 H717 C733 E848 C852 H710 C726 E841 C845 Q5NT71 GRTLGEQWKEKLNAMSREEFFKYRREAIIEVDRTEARRARRENNIVGGHPVSRGSAKLRWLVEKGFVSPIGKVIDLGCGRGGWSYYAATLKKVQEVRGYTKGGAGHEEPMLMQSYGWNLVSLKSGVDVFYKPSEPSDTLFCDIGESSPSPEVEEQRTLRVLEMTSDWLHRGPREFCIKVLCPYMPKVIEKMEVLQRRFGGGLVRLPLSRNSNHEMYWVSGAAGNVVHAVNMTSQVLLGRMDRTVWRGPKYEEDVNLGSGTRAVGKGSNQEKIKKRIQKLKEEFATTWHKDPEHPYRTWTYHGSYEVKATGSASSLVNGVVKLMSKPWDAIANVTTMAMTDTTPFGQQRVFKEKVDTKAPEPPAGAKEVLNETTNWLWAYLSREKRPRLCTKEEFIKKVNSNAALGAVFAEQNQWSTAREAVDDPRFWEMVDEERENHLRGECHTCIYNMMGKREKKPGEFGKAKGSRAIWFMWLGARYLEFEALGFLNEDHWLSRENSGGGVEGSGVQKLGYILRDIAGKQGGKMYADDTAGWDTRITRTDLENEAKVLELLDGEHRMLARAIIELTYRHKVVKVMRPAAEGKTVMDVISREDQRGSGQVVTYALNTFTNIAVQLVRLMEAEGVIGPQHLEQLPRKNKIAVRTWLFENGEERVTRMAISGDDCVVKPLDDRFATALHFLNAMSKVRKDIQEWKPSHGWHDWQQVPFCSNHFQEIVMKDGRSIVVPCRGQDELIGRARISPGAGWNVKDTACLAKAYAQMWLLLYFHRRDLRLMANAICSAVPVDWVPTGRTSWSIHSKGEWMTTEDMLQVWNRVWIEENEWMMDKTPITSWTDVPYVGKREDIWCGSLIGTRSRATWAENIYAAINQVRAVIGKENYVDYMTSLRRYE 4k6m B 2.60 BS03 ZN B 2 E440 H444 C449 C452 E433 H437 C442 C445 Q5NT71 GRTLGEQWKEKLNAMSREEFFKYRREAIIEVDRTEARRARRENNIVGGHPVSRGSAKLRWLVEKGFVSPIGKVIDLGCGRGGWSYYAATLKKVQEVRGYTKGGAGHEEPMLMQSYGWNLVSLKSGVDVFYKPSEPSDTLFCDIGESSPSPEVEEQRTLRVLEMTSDWLHRGPREFCIKVLCPYMPKVIEKMEVLQRRFGGGLVRLPLSRNSNHEMYWVSGAAGNVVHAVNMTSQVLLGRMDRTVWRGPKYEEDVNLGSGTRAVGKGSNQEKIKKRIQKLKEEFATTWHKDPEHPYRTWTYHGSYEVKATGSASSLVNGVVKLMSKPWDAIANVTTMAMTDTTPFGQQRVFKEKVDTKAPEPPAGAKEVLNETTNWLWAYLSREKRPRLCTKEEFIKKVNSNAALGAVFAEQNQWSTAREAVDDPRFWEMVDEERENHLRGECHTCIYNMMGKREKKPGEFGKAKGSRAIWFMWLGARYLEFEALGFLNEDHWLSRENSGGGVEGSGVQKLGYILRDIAGKQGGKMYADDTAGWDTRITRTDLENEAKVLELLDGEHRMLARAIIELTYRHKVVKVMRPAAEGKTVMDVISREDQRGSGQVVTYALNTFTNIAVQLVRLMEAEGVIGPQHLEQLPRKNKIAVRTWLFENGEERVTRMAISGDDCVVKPLDDRFATALHFLNAMSKVRKDIQEWKPSHGWHDWQQVPFCSNHFQEIVMKDGRSIVVPCRGQDELIGRARISPGAGWNVKDTACLAKAYAQMWLLLYFHRRDLRLMANAICSAVPVDWVPTGRTSWSIHSKGEWMTTEDMLQVWNRVWIEENEWMMDKTPITSWTDVPYVGKREDIWCGSLIGTRSRATWAENIYAAINQVRAVIGKENYVDYMTSLRRYE 4kff A 2.15 BS01 CU A 1 Y405 H456 H458 H624 Y390 H441 H443 H609 1.4.3.21 P12807 AAPARPAHPLDPLSTAEIKAATNTVKSYFAGKKISFNTVTLREPARKAYIQWKEQGGPLPPRLAYYVILEAGKPGVKEGLVDLASLSVIETRALETVQPILTVEDLCSTEEVIRNDPAVIEQCVLSGIPANEMHKVYCDPWTIGYDERWGTGKRLQQALVYYRSDEDDSQYSHPLDFCPIVDTEEKKVIFIDIPNRRRKVSKHKHANFYPKHMIEKVGAMRPEAPPINVTQPEGVSFKMTGNVMEWSNFKFHIGFNYREGIVLSDVSYNDHGNVRPIFHRISLSEMIVPYGSPEFPHQRKHALDIGEYGAGYMTNPLSLGCDCKGVIHYLDAHFSDRAGDPITVKNAVCIHEEDDGLLFKHSDFRDNFATSLVTRATKLVVSQIFTAANYEYCLYWVFMQDGAIRLDIRLTGILNTYILGDDEEAGPWGTRVYPNVNAHNHQHLFSLRIDPRIDGDGNSAAACDAKSSPYPLGSPENMYGNAFYSEKTTFKTVKDSLTNYESATGRSWDIFNPNKVNPYSGKPPSYKLVSTQCPPLLAKEGSLVAKRAPWASHSVNVVPYKDNRLYPSGDHVPQWSGDGVRGMREWIGDGSENIDNTDILFFHTFGITHFPAPEDFPLMPAEPITLMLRPRHFFTENPGLDIQPSYAMTTSEAKRAV 4kff B 2.15 BS01 CU B 1 Y405 H456 H458 H624 Y390 H441 H443 H609 1.4.3.21 P12807 AAPARPAHPLDPLSTAEIKAATNTVKSYFAGKKISFNTVTLREPARKAYIQWKEQGGPLPPRLAYYVILEAGKPGVKEGLVDLASLSVIETRALETVQPILTVEDLCSTEEVIRNDPAVIEQCVLSGIPANEMHKVYCDPWTIGYDERWGTGKRLQQALVYYRSDEDDSQYSHPLDFCPIVDTEEKKVIFIDIPNRRRKVSKHKHANFYPKHMIEKVGAMRPEAPPINVTQPEGVSFKMTGNVMEWSNFKFHIGFNYREGIVLSDVSYNDHGNVRPIFHRISLSEMIVPYGSPEFPHQRKHALDIGEYGAGYMTNPLSLGCDCKGVIHYLDAHFSDRAGDPITVKNAVCIHEEDDGLLFKHSDFRDNFATSLVTRATKLVVSQIFTAANYEYCLYWVFMQDGAIRLDIRLTGILNTYILGDDEEAGPWGTRVYPNVNAHNHQHLFSLRIDPRIDGDGNSAAACDAKSSPYPLGSPENMYGNAFYSEKTTFKTVKDSLTNYESATGRSWDIFNPNKVNPYSGKPPSYKLVSTQCPPLLAKEGSLVAKRAPWASHSVNVVPYKDNRLYPSGDHVPQWSGDGVRGMREWIGDGSENIDNTDILFFHTFGITHFPAPEDFPLMPAEPITLMLRPRHFFTENPGLDIQPSYAMTTSEAKRAV 4kff C 2.15 BS01 CU C 1 Y405 H456 H458 H624 Y390 H441 H443 H609 1.4.3.21 P12807 AAPARPAHPLDPLSTAEIKAATNTVKSYFAGKKISFNTVTLREPARKAYIQWKEQGGPLPPRLAYYVILEAGKPGVKEGLVDLASLSVIETRALETVQPILTVEDLCSTEEVIRNDPAVIEQCVLSGIPANEMHKVYCDPWTIGYDERWGTGKRLQQALVYYRSDEDDSQYSHPLDFCPIVDTEEKKVIFIDIPNRRRKVSKHKHANFYPKHMIEKVGAMRPEAPPINVTQPEGVSFKMTGNVMEWSNFKFHIGFNYREGIVLSDVSYNDHGNVRPIFHRISLSEMIVPYGSPEFPHQRKHALDIGEYGAGYMTNPLSLGCDCKGVIHYLDAHFSDRAGDPITVKNAVCIHEEDDGLLFKHSDFRDNFATSLVTRATKLVVSQIFTAANYEYCLYWVFMQDGAIRLDIRLTGILNTYILGDDEEAGPWGTRVYPNVNAHNHQHLFSLRIDPRIDGDGNSAAACDAKSSPYPLGSPENMYGNAFYSEKTTFKTVKDSLTNYESATGRSWDIFNPNKVNPYSGKPPSYKLVSTQCPPLLAKEGSLVAKRAPWASHSVNVVPYKDNRLYPSGDHVPQWSGDGVRGMREWIGDGSENIDNTDILFFHTFGITHFPAPEDFPLMPAEPITLMLRPRHFFTENPGLDIQPSYAMTTSEAKRA 4krs A 2.29 BS01 ZN A 1 C1234 H1237 C1242 C1245 C130 H133 C138 C141 2.4.2.30 O95271 23879431 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRAYAEYVIYRGEQAYPEYLITYQIMKPE 4krs A 2.29 BS02 1SX A 1 H1184 G1185 S1186 P1187 F1188 Y1203 Y1213 F1214 A1215 S1221 Y1224 H80 G81 S82 P83 F84 Y99 Y109 F110 A111 S117 Y120 2.4.2.30 O95271 23879431 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRAYAEYVIYRGEQAYPEYLITYQIMKPE 4krs B 2.29 BS01 ZN B 1 C1234 H1237 C1242 C1245 C130 H133 C138 C141 2.4.2.30 O95271 23879431 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNAYAEYVIYRGEQAYPEYLITYQIMKPE 4krs B 2.29 BS02 1SX B 1 H1184 G1185 S1186 P1187 F1188 Y1203 Y1213 F1214 A1215 K1220 S1221 Y1224 I1228 H80 G81 S82 P83 F84 Y99 Y109 F110 A111 K116 S117 Y120 I124 2.4.2.30 O95271 23879431 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNAYAEYVIYRGEQAYPEYLITYQIMKPE 4krv A 2.40 BS01 MN A 1 D254 H344 H347 D124 H214 H217 2.4.1.22 P08037 23942731 LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKTRHIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS 4krv A 2.40 BS02 UDH A 1 P187 F188 R189 R191 F226 D252 V253 D254 K279 W314 H344 H347 R349 D350 N353 P57 F58 R59 R61 F96 D122 V123 D124 K149 W184 H214 H217 R219 D220 N223 2.4.1.22 P08037 23942731 LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKTRHIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS 4krv A 2.40 BS03 NGS A 1 K279 F280 Y286 Y289 W314 G315 G316 D318 D319 R359 I363 K149 F150 Y156 Y159 W184 G185 G186 D188 D189 R229 I233 2.4.1.22 P08037 23942731 LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKTRHIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS 4krv A 2.40 BS04 SO4 A 1 Y171 M174 D175 Q210 Y41 M44 D45 Q80 2.4.1.22 P08037 23942731 LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKTRHIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS 4krv A 2.40 BS05 SO4 A 2 R265 F267 S268 R135 F137 S138 2.4.1.22 P08037 23942731 LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKTRHIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS 4krv A 2.40 BS06 SO4 A 3 S224 M225 K352 P401 S94 M95 K222 P271 2.4.1.22 P08037 23942731 LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKTRHIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS 4krv B 2.40 BS01 MN B 1 D254 H344 H347 D124 H214 H217 2.4.1.22 P08037 23942731 LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKTRHIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS 4krv B 2.40 BS02 UDH B 1 P187 F188 R189 R191 F226 D252 V253 D254 K279 W314 H344 H347 R349 D350 N353 P57 F58 R59 R61 F96 D122 V123 D124 K149 W184 H214 H217 R219 D220 N223 2.4.1.22 P08037 23942731 LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKTRHIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS 4krv B 2.40 BS03 NGS B 1 F280 Y286 Y289 W314 G315 G316 D318 D319 R359 F360 I363 F150 Y156 Y159 W184 G185 G186 D188 D189 R229 F230 I233 2.4.1.22 P08037 23942731 LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKTRHIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS 4krv B 2.40 BS04 SO4 B 1 R265 F267 S268 R135 F137 S138 2.4.1.22 P08037 23942731 LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKTRHIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS 4krv B 2.40 BS05 SO4 B 2 S224 M225 K352 P401 S94 M95 K222 P271 2.4.1.22 P08037 23942731 LTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKTRHIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS 4ky2 A 1.13 BS01 1W3 A 1 K15 L17 E54 A108 S117 K6 L8 E45 A99 S108 P02766 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNP 4ky2 B 1.13 BS01 1W3 B 1 K15 L17 A108 L110 S117 K6 L8 A99 L101 S108 P02766 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 4kzv A 1.40 BS01 TRE A 1 E135 E168 N170 L172 E176 R182 N192 D193 F198 E58 E91 N93 L95 E99 R105 N115 D116 F121 E1BHM0 ACPLKWFHFQSSCYLFSPDTMSWRASLKNCSSMGAHLVVINTQEEQEFLYYTKPRKKEFYIGLTDQVTEGQWQWVDGTPFTKSLSFWDAGEPNNLVTVEDCATIRDSSNPRQNWNDVPCFFNMFRVCEMPE 4kzv A 1.40 BS02 CA A 1 E168 N170 E176 N192 D193 E91 N93 E99 N115 D116 E1BHM0 ACPLKWFHFQSSCYLFSPDTMSWRASLKNCSSMGAHLVVINTQEEQEFLYYTKPRKKEFYIGLTDQVTEGQWQWVDGTPFTKSLSFWDAGEPNNLVTVEDCATIRDSSNPRQNWNDVPCFFNMFRVCEMPE 4kzv A 1.40 BS03 CA A 2 V116 N118 E122 E205 V39 N41 E45 E128 E1BHM0 ACPLKWFHFQSSCYLFSPDTMSWRASLKNCSSMGAHLVVINTQEEQEFLYYTKPRKKEFYIGLTDQVTEGQWQWVDGTPFTKSLSFWDAGEPNNLVTVEDCATIRDSSNPRQNWNDVPCFFNMFRVCEMPE 4kzv B 1.40 BS01 CA B 1 E168 N170 N171 N192 D193 E91 N93 N94 N110 D111 E1BHM0 ACPLKWFHFQSSCYLFSPDTMSWRASLKNCSSMGAHLVVINTQEEQEFLYYTKPRKKEFYIGLTDQVTEGQWQWVDGTPFTKSLSFWDAGEPNNDCATIRDSSNPRQNWNDVPCFFNMFRVCEMPER 4kzv B 1.40 BS02 CA B 2 V116 N118 E122 E205 V39 N41 E45 E123 E1BHM0 ACPLKWFHFQSSCYLFSPDTMSWRASLKNCSSMGAHLVVINTQEEQEFLYYTKPRKKEFYIGLTDQVTEGQWQWVDGTPFTKSLSFWDAGEPNNDCATIRDSSNPRQNWNDVPCFFNMFRVCEMPER 4kzw A 1.85 BS01 CA A 1 E168 N170 N192 D193 E90 N92 N114 D115 E1BHM0 CPLKWFHFQSSCYLFSPDTMSWRASLKNCSSMGAHLVVINTQEEQEFLYYTKPRKKEFYIGLTDQVTEGQWQWVDGTPFTKSLSFWDAGEPNNLVTVEDCATIRDSSNPRQNWNDVPCFFNMFRVCEMPERKI 4kzw A 1.85 BS02 CA A 2 V116 N118 E122 E205 V38 N40 E44 E127 E1BHM0 CPLKWFHFQSSCYLFSPDTMSWRASLKNCSSMGAHLVVINTQEEQEFLYYTKPRKKEFYIGLTDQVTEGQWQWVDGTPFTKSLSFWDAGEPNNLVTVEDCATIRDSSNPRQNWNDVPCFFNMFRVCEMPERKI 4kzw B 1.85 BS01 CA B 1 E168 N170 N192 D193 E91 N93 N112 D113 E1BHM0 ACPLKWFHFQSSCYLFSPDTMSWRASLKNCSSMGAHLVVINTQEEQEFLYYTKPRKKEFYIGLTDQVTEGQWQWVDGTPFTKSLSFWDAGEPNNVEDCATIRDSSNPRQNWNDVPCFFNMFRVCEMPERKI 4kzw B 1.85 BS02 CA B 2 V116 N118 E122 E205 V39 N41 E45 E125 E1BHM0 ACPLKWFHFQSSCYLFSPDTMSWRASLKNCSSMGAHLVVINTQEEQEFLYYTKPRKKEFYIGLTDQVTEGQWQWVDGTPFTKSLSFWDAGEPNNVEDCATIRDSSNPRQNWNDVPCFFNMFRVCEMPERKI 4l3a A 2.59 BS01 MG A 1 S280 Y283 N322 S233 Y236 N275 Q8Y7I7 DNVNIPDSTFKAYLNGLLGQASTANITEAQMDSLTYITLANINVTDLTGIEYAHNIKDLTINNIHATNYNQISGLSNLERLRIMGADVTSDKIPNLSGLTNLTLLDLSHSAHDDSILTKINTLPKVTSIDLSYNGAITDIMPLKTMPELKSLNIQFDGVHDYRGIEDFPKLNTLLAYSQTIGGKKLINSDIKSSKLTYNAENQTLYVPFSLMTERTVNYDGYVPDFVKSTASSDTYFTMNEQQVNGNRLTITSDGLTVSDVSKTDFDNLEKMEYNARIDLSYQSYNTPEQFQNGGSYTISMPIYDHYFTVDHSLNITADSEKTYIENQLVTEATFLSDIHAKTDDGSTVTSDFADKVDFNTPGTYTVTLQSENNAGLKATPVQVNVTIKAKTTITADEKITYKVDTSKTEAAFLADIKATTNDGTAITSDFATVVDLSKPGKYVVTLNAENDLQKALPVQVMVIVEKET 4l4j A 1.92 BS01 FUC A 1 F296 N297 F60 N61 P01859 23872058 ASSVFLFPPKPKDTLMISRTPEVTCVVVDVSAEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS 4lad B 2.30 BS01 ZN B 1 H361 C364 H23 C26 6.3.2.- Q9UKV5 23942235 DDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMGSADERQRMLVQRKDELLQQARKRFLN 4lad B 2.30 BS02 ZN B 2 C356 H358 C375 C378 C18 H20 C37 C40 6.3.2.- Q9UKV5 23942235 DDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMGSADERQRMLVQRKDELLQQARKRFLN 4lbp A 1.87 BS01 1WG A 1 R17 Y21 H24 G39 P40 S56 R17 Y21 H24 G39 P40 S56 Q45075 MLFLIYRKDRPGSLQVRIDNYAAHLAYLEPLKAKIQVGGPTLGAGTGTDDKDMTGSFLIMEAESWDEVHSFVENDPFTKAGLFAATIVERWKHGKHND 4lge A 1.55 BS01 ZN A 1 C300 C303 H320 C327 C46 C49 H66 C73 6.3.2.- Q13490 23928071 ISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY 4lge A 1.55 BS02 1Y0 A 1 D297 G306 L307 R308 C309 W310 E311 D314 E319 W323 F324 D43 G52 L53 R54 C55 W56 E57 D60 E65 W69 F70 6.3.2.- Q13490 23928071 ISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY 4lge B 1.55 BS01 ZN B 1 C300 C303 H320 C327 C47 C50 H67 C74 6.3.2.- Q13490 23928071 SISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY 4lge B 1.55 BS02 1Y0 B 1 D297 V298 G306 L307 R308 C309 W310 E311 D314 E319 W323 D44 V45 G53 L54 R55 C56 W57 E58 D61 E66 W70 6.3.2.- Q13490 23928071 SISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY 4lgu A 2.00 BS01 ZN A 1 C300 C303 H320 C327 C44 C47 H64 C71 6.3.2.- Q13490 23928071 NLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY 4lgu A 2.00 BS02 1YH A 1 D297 V298 G306 L307 R308 C309 W310 E311 D314 E319 W323 D41 V42 G50 L51 R52 C53 W54 E55 D58 E63 W67 6.3.2.- Q13490 23928071 NLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY 4lgu B 2.00 BS01 ZN B 1 C300 C303 H320 C327 C48 C51 H68 C75 6.3.2.- Q13490 23928071 SSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY 4lgu B 2.00 BS02 1YH B 1 D297 V298 G306 L307 R308 C309 W310 E311 D314 W323 D45 V46 G54 L55 R56 C57 W58 E59 D62 W71 6.3.2.- Q13490 23928071 SSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY 4lh0 A 1.67 BS01 GLV A 1 S349 G512 S513 F520 S319 G482 S483 F490 1.5.1.12 Q8CHT0 23928095 KVANEPILAFSQGSPERDALQKALKDLKGQTEAIPCVVGDEEVWTSDIQYQLSPFNHAHKVAKFCYADKALLNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWRYSYMQ 4lh0 B 1.67 BS01 GLV B 1 S349 G512 S513 F520 S330 G493 S494 F501 1.5.1.12 Q8CHT0 23928095 HMLRWKHTSSLKVANEPILAFSQGSPERDALQKALKDLKGQTEAIPCVVGDEEVWTSDIQYQLSPFNHAHKVAKFCYADKALLNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWRYSYMQ 4lh3 A 1.81 BS01 GUA A 1 N211 F212 I215 K347 C348 S349 G512 S513 F520 N181 F182 I185 K317 C318 S319 G482 S483 F490 1.5.1.12 Q8CHT0 23928095 KVANEPILAFSQGSPERDALQKALKDLKGQTEAIPCVVGDEEVWTSDIQYQLSPFNHAHKVAKFCYADKALLNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWRYSYMQ 4lh3 B 1.81 BS01 GUA B 1 N211 F212 I215 K347 C348 S349 T511 G512 S513 F520 N193 F194 I197 K329 C330 S331 T493 G494 S495 F502 1.5.1.12 Q8CHT0 23928095 SHMLRWKHTSSLKVANEPILAFSQGSPERDALQKALKDLKGQTEAIPCVVGDEEVWTSDIQYQLSPFNHAHKVAKFCYADKALLNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWRYSYMQ 4li5 A 2.64 BS01 1WY A 1 L718 G719 F723 V726 A743 T790 Q791 L792 M793 P794 G796 C797 D800 L844 L26 G27 F31 V34 A51 T98 Q99 L100 M101 P102 G104 C105 D108 L152 2.7.10.1 P00533 23930994 GSMGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDEDDVVDADEYLIPQ 4lji A 1.51 BS01 HEM A 1 N46 C47 C50 H51 T56 V62 S63 L64 D68 L69 R76 L82 F85 Q86 Y92 S98 S100 C101 R102 V104 L117 I121 N45 C46 C49 H50 T55 V61 S62 L63 D67 L68 R75 L81 F84 Q85 Y91 S97 S99 C100 R101 V103 L116 I120 Q8DJE2 AGVDNYVIQYLKVTDTVELPVNDRGETKTFTAVDLTRGKRLFEENCKNCHVGGSTLPNPLVSLSLKDLKGATPPRDTIASLVAFQRSPKSYDGSEESYSCRRVSEDWLTTEQLETLAAFILRAAAVAPGWGVE 4lji B 1.51 BS01 HEM A 1 N49 C50 N47 C48 Q8DJE2 GVDNYVIQYLKVTDTVELPVNDRGETKTFTAVDLTRGKRLFEENCKNCHVGGSTLPNPLVSLSLKDLKGATPPRDTIASLVAFQRSPKSYDGSEESYSCRRVSEDWLTTEQLETLAAFILRAAAVAPGWGV 4lji B 1.51 BS02 HEM B 1 N46 C47 C50 H51 T56 P58 V62 S63 L64 D68 A72 R76 L82 F85 Q86 Y92 S98 S100 C101 R102 V104 I121 N44 C45 C48 H49 T54 P56 V60 S61 L62 D66 A70 R74 L80 F83 Q84 Y90 S96 S98 C99 R100 V102 I119 Q8DJE2 GVDNYVIQYLKVTDTVELPVNDRGETKTFTAVDLTRGKRLFEENCKNCHVGGSTLPNPLVSLSLKDLKGATPPRDTIASLVAFQRSPKSYDGSEESYSCRRVSEDWLTTEQLETLAAFILRAAAVAPGWGV 4lom A 2.10 BS01 IYP A 1 H47 M107 H176 H177 E180 K184 H38 M98 H167 H168 E171 K175 4.2.1.19 I6XBW5 SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRV 4lom A 2.10 BS02 MN A 1 H73 E77 H152 H64 E68 H143 4.2.1.19 I6XBW5 SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRV 4lom A 2.10 BS03 MN A 2 H47 H176 E180 H38 H167 E171 4.2.1.19 I6XBW5 SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRV 4lom A 2.10 BS04 MN A 3 F104 R168 F95 R159 4.2.1.19 I6XBW5 SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRV 4lpf A 2.30 BS01 3TR A 1 H73 H74 E77 H64 H65 E68 4.2.1.19 I6XBW5 SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPR 4lpf A 2.30 BS02 MN A 1 H73 E77 H152 H64 E68 H143 4.2.1.19 I6XBW5 SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPR 4lpf A 2.30 BS03 MN A 2 H47 H176 E180 H38 H167 E171 4.2.1.19 I6XBW5 SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPR 4lpf A 2.30 BS04 MN A 3 F104 R168 F95 R159 4.2.1.19 I6XBW5 SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPR 4lwx A 1.78 BS01 MU2 A 1 V69 Y70 I71 M72 E85 S108 G109 N110 Y111 I155 A159 R163 V69 Y70 I71 M72 E85 S108 G109 N110 Y111 I155 A159 R163 3.2.2.22 D9J2T9 DVSFRLSGADPSSYGMFIKDLRNALPHTEKVYNIPLLLPSVSGAGRYLLMHLFNYDGNTITVAVDVTNVYIMGYLALTTSYFFNEPAADLASQYVFRSARRKITLPYSGNYERLQIAAGKPREKIPIGLPALDTAISTLLHYDSTAAAGALLVLIQTTAEAARFKYIEQQIQERAYRDEVPSSATISLENSWSGLSKQIQLAQGNNGVFRTPTVLVDSKGNRVQITNVTSNVVTSNIQLLLNTKNI 4lxa A 1.95 BS01 1YS A 1 Q60 G61 L78 D80 G82 S83 V117 P118 Y119 T120 G122 F156 I158 I166 I174 Y246 D276 G278 T279 T280 Q15 G16 L33 D35 G37 S38 V72 P73 Y74 T75 G77 F111 I113 I121 I129 Y189 D219 G221 T222 T223 3.4.23.46 P56817 22380629 SFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGSVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN 4lxa B 1.95 BS01 1YS B 1 Q60 G61 L78 D80 G82 S83 V117 P118 Y119 T120 F156 I158 I166 Y246 D276 G278 T279 T280 Q15 G16 L33 D35 G37 S38 V72 P73 Y74 T75 F111 I113 I121 Y191 D221 G223 T224 T225 3.4.23.46 P56817 22380629 SFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN 4lxa C 1.95 BS01 1YS C 1 Q60 G61 L78 D80 G82 S83 V117 P118 Y119 T120 Q121 F156 I158 I166 I174 Y246 D276 G278 T279 T280 Q15 G16 L33 D35 G37 S38 V72 P73 Y74 T75 Q76 F111 I113 I121 I129 Y194 D224 G226 T227 T228 3.4.23.46 P56817 22380629 SFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN 4lxk A 2.05 BS01 1YT A 1 Q60 G61 L78 D80 G82 S83 V117 P118 Y119 T120 Q121 G122 F156 I158 I174 Y246 D276 G278 T279 T280 Q15 G16 L33 D35 G37 S38 V72 P73 Y74 T75 Q76 G77 F111 I113 I129 Y189 D219 G221 T222 T223 3.4.23.46 P56817 22380629 SFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGSVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN 4lxk B 2.05 BS01 1YT B 1 Q60 G61 L78 D80 G82 S83 V117 P118 Y119 T120 G122 F156 W163 I166 I174 Y246 D276 G278 T279 T280 Q15 G16 L33 D35 G37 S38 V72 P73 Y74 T75 G77 F111 W118 I121 I129 Y191 D221 G223 T224 T225 3.4.23.46 P56817 22380629 SFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN 4lxk C 2.05 BS01 1YT C 1 G59 Q60 G61 L78 D80 G82 S83 V117 P118 Y119 T120 Q121 F156 I158 W163 I174 R176 Y246 D276 G278 T279 T280 G14 Q15 G16 L33 D35 G37 S38 V72 P73 Y74 T75 Q76 F111 I113 W118 I129 R131 Y194 D224 G226 T227 T228 3.4.23.46 P56817 22380629 SFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN 4lxm A 2.30 BS01 1YU A 1 Q60 G61 L78 D80 G82 S83 V117 P118 Y119 T120 Q121 F156 I174 R176 Y246 D276 G278 T279 Q15 G16 L33 D35 G37 S38 V72 P73 Y74 T75 Q76 F111 I129 R131 Y190 D220 G222 T223 3.4.23.46 P56817 22380629 SFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN 4lxm B 2.30 BS01 1YU B 1 Q60 G61 L78 D80 G82 S83 V117 P118 Y119 T120 F156 Y246 D276 G278 T279 Q15 G16 L33 D35 G37 S38 V72 P73 Y74 T75 F111 Y190 D220 G222 T223 3.4.23.46 P56817 22380629 SFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN 4lxm C 2.30 BS01 1YU C 1 Q60 G61 L78 D80 G82 S83 V117 P118 Y119 T120 F156 I158 R176 D276 G278 T279 Q15 G16 L33 D35 G37 S38 V72 P73 Y74 T75 F111 I113 R131 D224 G226 T227 3.4.23.46 P56817 22380629 SFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN 4ly4 A 2.20 BS01 ZN A 1 D14 H86 H90 D13 H85 H89 B5ZA76 AKEILVAYGVDIDAVAGWLGSYGGEDSPDDISRGLFAGEVGIPRLLKLFKKYHLPATWFVPGHSIETFPEQMKMIVDAGHEVGAHGYSHENPIAMSTKQEEDVLLKSVELIKDLTGKAPTGYVAPWWEFSNITNELLLKHGFKYDHSLMHNDFTPYYVRVGDSWSKIDYSLEAKDWMKPLIRGVETNLVEIPANWYLDDLPPMMFIKKSPNSFGFVSPRDIGQMWIDQFDWVYREMDYAVFSMTIHPDVSARPQVLLMHEKIIEHINKHEGVRWVTFNEIADDFLKRNPR 4ly4 B 2.20 BS01 ZN B 1 D14 H86 H90 D13 H85 H89 B5ZA76 AKEILVAYGVDIDAVAGWLGSYGGEDSPDDISRGLFAGEVGIPRLLKLFKKYHLPATWFVPGHSIETFPEQMKMIVDAGHEVGAHGYSHENPIAMSTKQEEDVLLKSVELIKDLTGKAPTGYVAPWWEFSNITNELLLKHGFKYDHSLMHNDFTPYYVRVGDSWSKIDYSLEAKDWMKPLIRGVETNLVEIPANWYLDDLPPMMFIKKSPNSFGFVSPRDIGQMWIDQFDWVYREMDYAVFSMTIHPDVSARPQVLLMHEKIIEHINKHEGVRWVTFNEIADDFLKRNPR 4ly4 C 2.20 BS01 ZN C 1 D14 H86 H90 D13 H85 H89 B5ZA76 AKEILVAYGVDIDAVAGWLGSYGGEDSPDDISRGLFAGEVGIPRLLKLFKKYHLPATWFVPGHSIETFPEQMKMIVDAGHEVGAHGYSHENPIAMSTKQEEDVLLKSVELIKDLTGKAPTGYVAPWWEFSNITNELLLKHGFKYDHSLMHNDFTPYYVRVGDSWSKIDYSLEAKDWMKPLIRGVETNLVEIPANWYLDDLPPMMFIKKSPNSFGFVSPRDIGQMWIDQFDWVYREMDYAVFSMTIHPDVSARPQVLLMHEKIIEHINKHEGVRWVTFNEIADDFLKRNPR 4ly4 D 2.20 BS01 ZN D 1 D14 H86 H90 D13 H85 H89 B5ZA76 AKEILVAYGVDIDAVAGWLGSYGGEDSPDDISRGLFAGEVGIPRLLKLFKKYHLPATWFVPGHSIETFPEQMKMIVDAGHEVGAHGYSHENPIAMSTKQEEDVLLKSVELIKDLTGKAPTGYVAPWWEFSNITNELLLKHGFKYDHSLMHNDFTPYYVRVGDSWSKIDYSLEAKDWMKPLIRGVETNLVEIPANWYLDDLPPMMFIKKSPNSFGFVSPRDIGQMWIDQFDWVYREMDYAVFSMTIHPDVSARPQVLLMHEKIIEHINKHEGVRWVTFNEIADDFLKRNPR 4m0l A 2.60 BS01 GDP A 1 V18 D19 G21 K22 T23 T24 N149 K150 D152 V153 S184 A185 L186 V17 D18 G20 K21 T22 T23 N146 K147 D149 V150 S181 A182 L183 Q980A5 AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 4m0l B 2.60 BS01 GDP B 1 V18 D19 H20 G21 K22 T23 T24 N149 K150 D152 V153 S184 A185 L186 V17 D18 H19 G20 K21 T22 T23 N138 K139 D141 V142 S173 A174 L175 Q980A5 AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKKGGVIGGSIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 4m0l C 2.60 BS01 GDP C 1 D19 H20 G21 K22 T23 T24 N149 K150 D152 S184 A185 L186 D18 H19 G20 K21 T22 T23 N140 K141 D143 S175 A176 L177 Q980A5 AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKHTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 4m0l C 2.60 BS02 MG C 1 T54 T70 E71 T45 T61 E62 Q980A5 AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKHTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 4m0l D 2.60 BS01 GDP D 1 D19 G21 K22 T23 T24 N149 K150 D152 V153 S184 A185 L186 D18 G20 K21 T22 T23 N139 K140 D142 V143 S174 A175 L176 Q980A5 AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 4m0l E 2.60 BS01 GDP E 1 H17 D19 H20 G21 K22 T23 T24 N149 K150 D152 V153 S184 A185 L186 H16 D18 H19 G20 K21 T22 T23 N139 K140 D142 V143 S174 A175 L176 Q980A5 AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 4m0l F 2.60 BS01 GDP F 1 D19 G21 K22 T23 T24 N149 K150 D152 V153 S184 A185 L186 D18 G20 K21 T22 T23 N148 K149 D151 V152 S183 A184 L185 Q980A5 AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 4m1j C 1.80 BS01 B0S C 1 S217 P238 H239 F240 T285 V286 V374 W378 N485 S1 P22 H23 F24 T69 V70 V158 W162 N269 3.5.1.97 Q9I194 23883096 SNAIAVGSERSADGKGMLLANPHFPWNGAMRFYQMHLTIPGRLDVMGASLPGLPVVNIGFSRHLAWTHTVDTSSHFTLYRLALDPKDPRRYLVDGRSLPLEEKSVAIEVRGADGKLSRVEHKVYQSIYGPLVVWPGKLDWNRSEAYALRDANLENTRVLQQWYSINQASDVADLRRRVEALQGIPWVNTLAADEQGNALYMNQSVVPYLKPELIPACAIPQLVAEGLPALQGQDSRCAWSRDPAAAQAGITPAAQLPVLLRRDFVQNSNDSAWLTNPASPLQGFSPLVSQEKPIGPRARYALSRLQGKQPLEAKTLEEMVTANHVFSADQVLPDLLRLCRDNQGEKSLARACAALAQWDRGANLDSGSGFVYFQRFMQRFAELDGAWKEPFDAQRPLDTPQGIALDRPQVATQVRQALADAAAEVEKSGIPDGARWGDLQVSTRGQERIAIPGGDGHFGVYNAIQSVRKGDHLEVVGGTSYIQLVTFPEEGPKARGLLAFSQSSDPRSPHYRDQTELFSRQQWQTLPFSDRQIDADPQLQRLSIREAA 4m55 A 2.86 BS01 NAD A 1 G95 A97 G98 F99 V100 D119 N120 F121 F122 T123 G124 H143 D144 V145 L159 A160 S161 T178 S201 T202 K235 I258 F259 T261 H267 G8 A10 G11 F12 V13 D32 N33 F34 F35 T36 G37 H56 D57 V58 L72 A73 S74 T84 S107 T108 K114 I137 F138 T140 H146 4.1.1.35 Q8NBZ7 RKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGKHVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQA 4m55 A 2.86 BS02 POP A 1 G188 K191 Y245 G94 K97 Y124 4.1.1.35 Q8NBZ7 RKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGKHVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQA 4m55 B 2.86 BS01 NAD B 1 G95 A97 G98 F99 V100 D119 N120 F121 F122 T123 G124 H143 D144 V145 L159 S161 P162 T178 T202 K235 I258 T261 H267 R272 G8 A10 G11 F12 V13 D32 N33 F34 F35 T36 G37 H56 D57 V58 L72 S74 P75 T87 T111 K118 I141 T144 H150 R155 4.1.1.35 Q8NBZ7 RKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYEGKHVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQA 4m55 B 2.86 BS02 UDP B 1 P148 L149 Y150 L184 N185 G188 L189 R192 Y245 P61 L62 Y63 L93 N94 G97 L98 R101 Y128 4.1.1.35 Q8NBZ7 RKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYEGKHVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQA 4m55 C 2.86 BS01 NAD C 1 G95 A97 G98 F99 V100 D119 N120 F121 F122 T123 G124 H143 D144 V145 L159 A160 S161 P162 A163 T178 T202 K235 I258 T261 H267 R272 G8 A10 G11 F12 V13 D32 N33 F34 F35 T36 G37 H56 D57 V58 L72 A73 S74 P75 A76 T86 T110 K117 I140 T143 H149 R154 4.1.1.35 Q8NBZ7 RKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYEGKHVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQA 4m55 C 2.86 BS02 POP C 1 G188 Y245 G96 Y127 4.1.1.35 Q8NBZ7 RKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYEGKHVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQA 4m55 D 2.86 BS01 NAD D 1 G95 A97 G98 F99 V100 D119 N120 F121 F122 T123 G124 H143 D144 V145 L159 A160 S161 T178 T202 K235 I258 F259 T261 H267 G8 A10 G11 F12 V13 D32 N33 F34 F35 T36 G37 H56 D57 V58 L72 A73 S74 T83 T107 K113 I136 F137 T139 H145 4.1.1.35 Q8NBZ7 RKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGKHVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKEL 4m55 D 2.86 BS02 UDP D 1 P148 L184 N185 G188 K191 Y245 P61 L89 N90 G93 K96 Y123 4.1.1.35 Q8NBZ7 RKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGKHVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKEL 4m55 E 2.86 BS01 NAD E 1 G95 A97 G98 F99 V100 D119 N120 F121 F122 T123 G124 H143 D144 V145 L159 S161 P162 T178 T202 T261 G6 A8 G9 F10 V11 D30 N31 F32 F33 T34 G35 H54 D55 V56 L70 S72 P73 T81 T105 T131 4.1.1.35 Q8NBZ7 RILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSVAETMCYAYMKQEGVEVRVARIFNTFQYVSDLVNGLVALMNSNVSSPVNLDIKKAKLM 4m55 F 2.86 BS01 NAD F 1 A97 G98 F99 V100 D119 N120 F121 F122 T123 G124 H143 D144 V145 K174 T178 T261 H267 R272 A3 G4 F5 V6 D17 N18 F19 F20 T21 G22 H34 D35 V36 K51 T55 T88 H94 R99 4.1.1.35 Q8NBZ7 GGAGFVGSHLTDKLMVDNFFTGRKRNVEHWIINHDVVEPLYIEVDQYNPIKTLKTNTIGTLNMLGLAKRVGVAETMCYAYMKQEGVETFGPRMHMNDGRVVSNFILQALQVSDLVNGLVALMNSNVSSPVNLTILEFAQLIKNLVDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQA 4m5a A 1.70 BS01 DA2 A 1 Y70 I71 M72 E85 G109 Y111 I155 E160 R163 Y70 I71 M72 E85 G109 Y111 I155 E160 R163 3.2.2.22 D9J2T9 DVSFRLSGADPSSYGMFIKDLRNALPHTEKVYNIPLLLPSVSGAGRYLLMHLFNYDGNTITVAVDVTNVYIMGYLALTTSYFFNEPAADLASQYVFRSARRKITLPYSGNYERLQIAAGKPREKIPIGLPALDTAISTLLHYDSTAAAGALLVLIQTTAEAARFKYIEQQIQERAYRDEVPSSATISLENSWSGLSKQIQLAQGNNGVFRTPTVLVDSKGNRVQITNVTSNVVTSNIQLLLNTKNI 4m7n A 2.05 BS01 CA A 1 D415 D417 N419 Y421 E423 E426 D380 D382 N384 Y386 E388 E391 2.7.11.17 Q9BJF5 LHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVMEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFEPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLLCGNL 4m7n A 2.05 BS02 CA A 2 D368 N370 D372 Q374 E379 D333 N335 D337 Q339 E344 2.7.11.17 Q9BJF5 LHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVMEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFEPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLLCGNL 4m7n A 2.05 BS03 CA A 3 D451 D453 S455 K457 E462 D416 D418 S420 K422 E427 2.7.11.17 Q9BJF5 LHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVMEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFEPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLLCGNL 4m7n A 2.05 BS04 CA A 4 D485 N487 D489 E491 E496 D450 N452 D454 E456 E461 2.7.11.17 Q9BJF5 LHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVMEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFEPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLLCGNL 4m7n A 2.05 BS05 ANP A 1 L57 G58 K59 V65 A78 K80 E129 V130 Y131 E135 L181 D195 L26 G27 K28 V34 A47 K49 E95 V96 Y97 E101 L147 D161 2.7.11.17 Q9BJF5 LHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVMEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFEPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLLCGNL 4m9d A 1.82 BS01 AMP A 1 W11 G12 N38 G126 T127 T128 Q223 L227 V237 T238 V272 G273 W11 G12 N38 G126 T127 T128 Q223 L227 V237 T238 V272 G273 6.3.4.4 Q81JI9 MSSVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLEELKYLHDRGVSTDNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKLEQNLAQKNRLFEKMYDTEGFSVDEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSSNPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGLTDLSLNSIDVLTGIPTLKICVAYKCDGKVIDEVPANLNILAKCEPVCEELPGWTEDITGVRSLDELPENARKYVERVSELTGIQLSMFSVGPDRNQTNIV 4m9d B 1.82 BS01 AMP B 1 W11 D13 N38 G126 T127 T128 Q223 L227 V237 T238 V272 G273 W14 D16 N41 G129 T130 T131 Q226 L230 V240 T241 V275 G276 6.3.4.4 Q81JI9 SNAMSSVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLEELKYLHDRGVSTDNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKLEQNLAQKNRLFEKMYDTEGFSVDEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSSNPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGLTDLSLNSIDVLTGIPTLKICVAYKCDGKVIDEVPANLNILAKCEPVCEELPGWTEDITGVRSLDELPENARKYVERVSELTGIQLSMFSVGPDRNQTNIVRNVYE 4ma0 A 1.98 BS01 AMP A 1 I136 K138 Q149 E175 A176 F177 V178 F180 E183 H206 F249 E259 I136 K138 Q149 E175 A176 F177 V178 F180 E183 H206 F249 E259 4.1.1.21 Q5NGE8 MKIGIIGAGQLARMLSLAGTPLGLEFHCLGKNGDCAEEVVKTVTDIELTKVNDVVAWAKQFDVITFENENISHELIKAINHEVSVYPSAKAIAISQDRLLEKSFMQDHGIATAKFVNIDSLAKLQSAVDDHGLPAILKTRRFGYDGKGQFVIRSQEDITKAWDVLKDAPDGLIYEAFVDFDYEVSQICTADLKGNIAFYPLARNTHKQGIIVESEAPFENVVLAEKAQQIAKILVKEFAYVGTLAIEFFVKGDELIVNEIAPRVHNSGHWSIDGAVTSQFENHVRAIAGLILGDTTSRKTVMLNCIGGMPATKDLAALDRVKIHSYNKEPRKGRKVGHLNLNLNDETDEYQLLQVKKLIALSEEIA 4ma5 A 1.81 BS01 ANP A 1 I136 K138 Y144 D145 G146 E175 A176 F177 V178 E183 H206 G209 E247 F249 N258 E259 H265 I136 K138 Y144 D145 G146 E175 A176 F177 V178 E183 H206 G209 E247 F249 N256 E257 H263 4.1.1.21 Q5NGE8 MKIGIIGAGQLARMLSLAGTPLGLEFHCLGKNGDCAEEVVKTVTDIELTKVNDVVAWAKQFDVITFENENISHELIKAINHEVSVYPSAKAIAISQDRLLEKSFMQDHGIATAKFVNIDSLAKLQSAVDDHGLPAILKTRRFGYDGKGQFVIRSQEDITKAWDVLKDAPDGLIYEAFVDFDYEVSQICTADLKGNIAFYPLARNTHKQGIIVESEAPFENVVLAEKAQQIAKILVKEFAYVGTLAIEFFVKELIVNEIAPRVHNSGHWSIDGAVTSQFENHVRAIAGLILGDTTSRKTVMLNCIGGMPATKDLAALDRVKIHSYNKEPRKGRKVGHLNLNLNDETDEYQLLQVKKLIALSEEI 4mam A 1.47 BS01 A12 A 1 R98 I136 K138 Y144 D145 G146 Q149 E175 A176 F177 V178 F180 E183 H206 F249 N258 E259 Y371 R98 I136 K138 Y144 D145 G146 Q149 E175 A176 F177 V178 F180 E183 H206 F249 N258 E259 Y371 4.1.1.21 Q5NGE8 MKIGIIGAGQLARMLSLAGTPLGLEFHCLGKNGDCAEEVVKTVTDIELTKVNDVVAWAKQFDVITFENENISHELIKAINHEVSVYPSAKAIAISQDRLLEKSFMQDHGIATAKFVNIDSLAKLQSAVDDHGLPAILKTRRFGYDGKGQFVIRSQEDITKAWDVLKDAPDGLIYEAFVDFDYEVSQICTADLKGNIAFYPLARNTHKQGIIVESEAPFENVVLAEKAQQIAKILVKEFAYVGTLAIEFFVKGDELIVNEIAPRVHNSGHWSIDGAVTSQFENHVRAIAGLILGDTTSRKTVMLNCIGGMPATKDLAALDRVKIHSYNKEPRKGRKVGHLNLNLNDETDEYQLLQVKKLIALSEEIAGENLYFQ 4mam B 1.47 BS01 A12 B 1 R98 I136 K138 Y144 D145 G146 Q149 E175 A176 F177 V178 F180 E183 F249 N258 E259 R98 I136 K138 Y144 D145 G146 Q149 E175 A176 F177 V178 F180 E183 F249 N258 E259 4.1.1.21 Q5NGE8 MKIGIIGAGQLARMLSLAGTPLGLEFHCLGKNGDCAEEVVKTVTDIELTKVNDVVAWAKQFDVITFENENISHELIKAINHEVSVYPSAKAIAISQDRLLEKSFMQDHGIATAKFVNIDSLAKLQSAVDDHGLPAILKTRRFGYDGKGQFVIRSQEDITKAWDVLKDAPDGLIYEAFVDFDYEVSQICTADLKGNIAFYPLARNTHKQGIIVESEAPFENVVLAEKAQQIAKILVKEFAYVGTLAIEFFVKGDELIVNEIAPRVHNSGHWSIDGAVTSQFENHVRAIAGLILGDTTSRKTVMLNCIGGMPATKDLAALDRVKIHSYNKEPRKGRKVGHLNLNLNDETDEYQLLQVKKLIALSEEI 4max A 1.44 BS01 HEB A 1 F34 F35 K42 H46 D49 F50 Y53 F61 M66 H70 L73 L79 F84 I87 H117 V121 F33 F34 K41 H45 D48 F49 Y52 F60 M65 H69 L72 L78 F83 I86 H116 V120 Q8RT58 ASLYEKLGGAAAVDLAVEKFYGKVLADERVNRFFVNTDMAKQKQHQKDFMTYAFGGTDRFPGRSMRAAHQDLVENAGLTDVHFDAIAENLVLTLQELNVSQDLIDEVVTIVGSVQHRNDVLNR 4max B 1.44 BS01 HEB B 1 F34 F35 K42 H46 F50 Y53 F61 M66 H70 L73 L79 F84 I87 H117 F33 F34 K41 H45 F49 Y52 F60 M65 H69 L72 L78 F83 I86 H116 Q8RT58 ASLYEKLGGAAAVDLAVEKFYGKVLADERVNRFFVNTDMAKQKQHQKDFMTYAFGGTDRFPGRSMRAAHQDLVENAGLTDVHFDAIAENLVLTLQELNVSQDLIDEVVTIVGSVQHRNDVLNR 4max C 1.44 BS01 HEB C 1 F34 F35 K42 H46 D49 F50 Y53 F61 M66 A69 H70 L73 L79 F84 I87 H117 F33 F34 K41 H45 D48 F49 Y52 F60 M65 A68 H69 L72 L78 F83 I86 H116 Q8RT58 ASLYEKLGGAAAVDLAVEKFYGKVLADERVNRFFVNTDMAKQKQHQKDFMTYAFGGTDRFPGRSMRAAHQDLVENAGLTDVHFDAIAENLVLTLQELNVSQDLIDEVVTIVGSVQHRNDVLNR